-- dump date   	20140620_072519
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
665571000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
665571000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
665571000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571000004	Walker A motif; other site
665571000005	ATP binding site [chemical binding]; other site
665571000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
665571000007	Walker B motif; other site
665571000008	arginine finger; other site
665571000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
665571000010	DnaA box-binding interface [nucleotide binding]; other site
665571000011	DNA polymerase III subunit beta; Provisional; Region: PRK14940
665571000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
665571000013	putative DNA binding surface [nucleotide binding]; other site
665571000014	dimer interface [polypeptide binding]; other site
665571000015	beta-clamp/clamp loader binding surface; other site
665571000016	beta-clamp/translesion DNA polymerase binding surface; other site
665571000017	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
665571000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571000019	Walker A/P-loop; other site
665571000020	ATP binding site [chemical binding]; other site
665571000021	Q-loop/lid; other site
665571000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571000023	ABC transporter signature motif; other site
665571000024	Walker B; other site
665571000025	D-loop; other site
665571000026	H-loop/switch region; other site
665571000027	Protein of unknown function (DUF721); Region: DUF721; pfam05258
665571000028	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571000029	MULE transposase domain; Region: MULE; pfam10551
665571000030	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
665571000031	Haemolytic domain; Region: Haemolytic; pfam01809
665571000032	membrane protein insertase; Provisional; Region: PRK01318
665571000033	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
665571000034	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
665571000035	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
665571000036	G-X-X-G motif; other site
665571000037	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
665571000038	RxxxH motif; other site
665571000039	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
665571000040	lipoyl attachment site [posttranslational modification]; other site
665571000041	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
665571000042	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
665571000043	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
665571000044	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
665571000045	Adenosylhomocysteinase; Provisional; Region: PTZ00075
665571000046	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
665571000047	homotetramer interface [polypeptide binding]; other site
665571000048	ligand binding site [chemical binding]; other site
665571000049	catalytic site [active]
665571000050	NAD binding site [chemical binding]; other site
665571000051	S-adenosylmethionine synthetase; Validated; Region: PRK05250
665571000052	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
665571000053	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
665571000054	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
665571000055	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
665571000056	putative active site [active]
665571000057	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571000058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000059	active site
665571000060	phosphorylation site [posttranslational modification]
665571000061	intermolecular recognition site; other site
665571000062	dimerization interface [polypeptide binding]; other site
665571000063	PAS fold; Region: PAS; pfam00989
665571000064	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
665571000065	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
665571000066	active site
665571000067	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
665571000068	substrate binding site [chemical binding]; other site
665571000069	catalytic residues [active]
665571000070	dimer interface [polypeptide binding]; other site
665571000071	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
665571000072	GAF domain; Region: GAF_3; pfam13492
665571000073	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571000074	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571000075	metal binding site [ion binding]; metal-binding site
665571000076	active site
665571000077	I-site; other site
665571000078	Bifunctional nuclease; Region: DNase-RNase; pfam02577
665571000079	UvrB/uvrC motif; Region: UVR; pfam02151
665571000080	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
665571000081	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
665571000082	active site
665571000083	catalytic site [active]
665571000084	NAD synthetase; Provisional; Region: PRK13981
665571000085	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
665571000086	multimer interface [polypeptide binding]; other site
665571000087	active site
665571000088	catalytic triad [active]
665571000089	protein interface 1 [polypeptide binding]; other site
665571000090	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
665571000091	homodimer interface [polypeptide binding]; other site
665571000092	NAD binding pocket [chemical binding]; other site
665571000093	ATP binding pocket [chemical binding]; other site
665571000094	Mg binding site [ion binding]; other site
665571000095	active-site loop [active]
665571000096	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
665571000097	prolyl-tRNA synthetase; Provisional; Region: PRK08661
665571000098	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
665571000099	dimer interface [polypeptide binding]; other site
665571000100	motif 1; other site
665571000101	active site
665571000102	motif 2; other site
665571000103	motif 3; other site
665571000104	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
665571000105	anticodon binding site; other site
665571000106	zinc-binding site [ion binding]; other site
665571000107	Predicted secreted protein [Function unknown]; Region: COG5497
665571000108	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
665571000109	6-phosphofructokinase; Provisional; Region: PRK03202
665571000110	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
665571000111	active site
665571000112	ADP/pyrophosphate binding site [chemical binding]; other site
665571000113	dimerization interface [polypeptide binding]; other site
665571000114	allosteric effector site; other site
665571000115	fructose-1,6-bisphosphate binding site; other site
665571000116	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
665571000117	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
665571000118	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571000119	Zn2+ binding site [ion binding]; other site
665571000120	Mg2+ binding site [ion binding]; other site
665571000121	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
665571000122	putative acyl-acceptor binding pocket; other site
665571000123	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
665571000124	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571000125	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
665571000126	Protein of unknown function (DUF342); Region: DUF342; pfam03961
665571000127	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
665571000128	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
665571000129	P-loop; other site
665571000130	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
665571000131	C-terminal peptidase (prc); Region: prc; TIGR00225
665571000132	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
665571000133	protein binding site [polypeptide binding]; other site
665571000134	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
665571000135	Catalytic dyad [active]
665571000136	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
665571000137	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
665571000138	Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808
665571000139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
665571000140	active site
665571000141	phosphorylation site [posttranslational modification]
665571000142	intermolecular recognition site; other site
665571000143	dimerization interface [polypeptide binding]; other site
665571000144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571000145	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
665571000146	Walker A motif; other site
665571000147	ATP binding site [chemical binding]; other site
665571000148	Walker B motif; other site
665571000149	arginine finger; other site
665571000150	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
665571000151	classical (c) SDRs; Region: SDR_c; cd05233
665571000152	NAD(P) binding site [chemical binding]; other site
665571000153	active site
665571000154	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
665571000155	anti sigma factor interaction site; other site
665571000156	regulatory phosphorylation site [posttranslational modification]; other site
665571000157	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
665571000158	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
665571000159	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
665571000160	DNA binding site [nucleotide binding]
665571000161	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
665571000162	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
665571000163	putative NAD(P) binding site [chemical binding]; other site
665571000164	active site
665571000165	putative substrate binding site [chemical binding]; other site
665571000166	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
665571000167	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
665571000168	hinge; other site
665571000169	active site
665571000170	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
665571000171	aspartate kinase; Provisional; Region: PRK06291
665571000172	putative catalytic residues [active]
665571000173	putative nucleotide binding site [chemical binding]; other site
665571000174	putative aspartate binding site [chemical binding]; other site
665571000175	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
665571000176	dimer interface [polypeptide binding]; other site
665571000177	putative threonine allosteric regulatory site; other site
665571000178	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
665571000179	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
665571000180	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
665571000181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571000182	catalytic residue [active]
665571000183	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
665571000184	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
665571000185	putative trimer interface [polypeptide binding]; other site
665571000186	putative CoA binding site [chemical binding]; other site
665571000187	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
665571000188	potential frameshift: common BLAST hit: gi|42527066|ref|NP_972164.1| YD repeat-containing protein
665571000189	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
665571000190	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
665571000191	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
665571000192	NAD binding site [chemical binding]; other site
665571000193	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
665571000194	Predicted membrane protein [Function unknown]; Region: COG2246
665571000195	GtrA-like protein; Region: GtrA; pfam04138
665571000196	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
665571000197	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
665571000198	active site
665571000199	catalytic tetrad [active]
665571000200	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
665571000201	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571000202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000203	active site
665571000204	phosphorylation site [posttranslational modification]
665571000205	intermolecular recognition site; other site
665571000206	dimerization interface [polypeptide binding]; other site
665571000207	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
665571000208	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
665571000209	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
665571000210	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
665571000211	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571000212	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571000213	metal binding site [ion binding]; metal-binding site
665571000214	active site
665571000215	I-site; other site
665571000216	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
665571000217	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
665571000218	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
665571000219	Part of AAA domain; Region: AAA_19; pfam13245
665571000220	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
665571000221	Family description; Region: UvrD_C_2; pfam13538
665571000222	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
665571000223	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
665571000224	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
665571000225	dimer interface [polypeptide binding]; other site
665571000226	active site
665571000227	CoA binding pocket [chemical binding]; other site
665571000228	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
665571000229	MG2 domain; Region: A2M_N; pfam01835
665571000230	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
665571000231	surface patch; other site
665571000232	thioester region; other site
665571000233	specificity defining residues; other site
665571000234	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
665571000235	Transglycosylase; Region: Transgly; pfam00912
665571000236	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
665571000237	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
665571000238	Domain of unknown function (DUF377); Region: DUF377; pfam04041
665571000239	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
665571000240	active site
665571000241	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571000242	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
665571000243	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
665571000244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571000245	dimer interface [polypeptide binding]; other site
665571000246	conserved gate region; other site
665571000247	putative PBP binding loops; other site
665571000248	ABC-ATPase subunit interface; other site
665571000249	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571000250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571000251	dimer interface [polypeptide binding]; other site
665571000252	conserved gate region; other site
665571000253	putative PBP binding loops; other site
665571000254	ABC-ATPase subunit interface; other site
665571000255	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571000256	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
665571000257	sugar binding site [chemical binding]; other site
665571000258	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571000259	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571000260	DNA binding site [nucleotide binding]
665571000261	domain linker motif; other site
665571000262	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571000263	dimerization interface [polypeptide binding]; other site
665571000264	ligand binding site [chemical binding]; other site
665571000265	Domain of unknown function (DUF377); Region: DUF377; pfam04041
665571000266	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
665571000267	active site
665571000268	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
665571000269	dimerization interface [polypeptide binding]; other site
665571000270	putative active cleft [active]
665571000271	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
665571000272	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571000273	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
665571000274	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
665571000275	catalytic triad [active]
665571000276	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
665571000277	active site
665571000278	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
665571000279	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
665571000280	active site 2 [active]
665571000281	Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513
665571000282	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571000283	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000284	dimer interface [polypeptide binding]; other site
665571000285	putative CheW interface [polypeptide binding]; other site
665571000286	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
665571000287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
665571000288	active site
665571000289	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
665571000290	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
665571000291	active site
665571000292	Response regulator receiver domain; Region: Response_reg; pfam00072
665571000293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000294	active site
665571000295	phosphorylation site [posttranslational modification]
665571000296	intermolecular recognition site; other site
665571000297	dimerization interface [polypeptide binding]; other site
665571000298	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571000299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571000300	dimer interface [polypeptide binding]; other site
665571000301	phosphorylation site [posttranslational modification]
665571000302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571000303	ATP binding site [chemical binding]; other site
665571000304	Mg2+ binding site [ion binding]; other site
665571000305	G-X-G motif; other site
665571000306	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
665571000307	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
665571000308	FMN binding site [chemical binding]; other site
665571000309	active site
665571000310	catalytic residues [active]
665571000311	substrate binding site [chemical binding]; other site
665571000312	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
665571000313	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
665571000314	ligand binding site [chemical binding]; other site
665571000315	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571000316	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000317	dimer interface [polypeptide binding]; other site
665571000318	putative CheW interface [polypeptide binding]; other site
665571000319	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
665571000320	dimerization interface [polypeptide binding]; other site
665571000321	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
665571000322	cyclase homology domain; Region: CHD; cd07302
665571000323	nucleotidyl binding site; other site
665571000324	metal binding site [ion binding]; metal-binding site
665571000325	dimer interface [polypeptide binding]; other site
665571000326	TPR repeat; Region: TPR_11; pfam13414
665571000327	binding surface
665571000328	Tetratricopeptide repeat; Region: TPR_2; pfam07719
665571000329	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
665571000330	Tetratricopeptide repeat; Region: TPR_15; pfam13429
665571000331	Cache domain; Region: Cache_2; pfam08269
665571000332	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000333	dimer interface [polypeptide binding]; other site
665571000334	putative CheW interface [polypeptide binding]; other site
665571000335	pyruvate kinase; Provisional; Region: PRK05826
665571000336	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
665571000337	domain interfaces; other site
665571000338	active site
665571000339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571000340	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571000341	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
665571000342	HEAT-like repeat; Region: HEAT_EZ; pfam13513
665571000343	protein binding surface [polypeptide binding]; other site
665571000344	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
665571000345	putative binding surface; other site
665571000346	active site
665571000347	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
665571000348	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
665571000349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571000350	ATP binding site [chemical binding]; other site
665571000351	Mg2+ binding site [ion binding]; other site
665571000352	G-X-G motif; other site
665571000353	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
665571000354	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571000355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000356	active site
665571000357	phosphorylation site [posttranslational modification]
665571000358	intermolecular recognition site; other site
665571000359	dimerization interface [polypeptide binding]; other site
665571000360	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
665571000361	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000362	dimer interface [polypeptide binding]; other site
665571000363	putative CheW interface [polypeptide binding]; other site
665571000364	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
665571000365	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
665571000366	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571000367	S-adenosylmethionine binding site [chemical binding]; other site
665571000368	CheD chemotactic sensory transduction; Region: CheD; cl00810
665571000369	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
665571000370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000371	active site
665571000372	phosphorylation site [posttranslational modification]
665571000373	intermolecular recognition site; other site
665571000374	dimerization interface [polypeptide binding]; other site
665571000375	CheB methylesterase; Region: CheB_methylest; pfam01339
665571000376	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
665571000377	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
665571000378	substrate binding site [chemical binding]; other site
665571000379	ligand binding site [chemical binding]; other site
665571000380	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
665571000381	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
665571000382	substrate binding site [chemical binding]; other site
665571000383	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
665571000384	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
665571000385	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
665571000386	Domain of unknown function DUF21; Region: DUF21; pfam01595
665571000387	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
665571000388	Transporter associated domain; Region: CorC_HlyC; smart01091
665571000389	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
665571000390	catalytic residues [active]
665571000391	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
665571000392	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
665571000393	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
665571000394	phosphate binding site [ion binding]; other site
665571000395	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
665571000396	metal binding site [ion binding]; metal-binding site
665571000397	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
665571000398	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
665571000399	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
665571000400	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
665571000401	TPP-binding site [chemical binding]; other site
665571000402	dimer interface [polypeptide binding]; other site
665571000403	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
665571000404	PYR/PP interface [polypeptide binding]; other site
665571000405	dimer interface [polypeptide binding]; other site
665571000406	TPP binding site [chemical binding]; other site
665571000407	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
665571000408	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
665571000409	nucleotide binding site [chemical binding]; other site
665571000410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000411	binding surface
665571000412	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571000413	TPR motif; other site
665571000414	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000415	TPR motif; other site
665571000416	binding surface
665571000417	TPR repeat; Region: TPR_11; pfam13414
665571000418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000419	binding surface
665571000420	TPR motif; other site
665571000421	TPR repeat; Region: TPR_11; pfam13414
665571000422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000423	binding surface
665571000424	TPR motif; other site
665571000425	DHH family; Region: DHH; pfam01368
665571000426	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
665571000427	Uncharacterized conserved protein [Function unknown]; Region: COG1434
665571000428	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
665571000429	putative active site [active]
665571000430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571000431	phosphorylation site [posttranslational modification]
665571000432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571000433	ATP binding site [chemical binding]; other site
665571000434	Mg2+ binding site [ion binding]; other site
665571000435	G-X-G motif; other site
665571000436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000437	active site
665571000438	phosphorylation site [posttranslational modification]
665571000439	intermolecular recognition site; other site
665571000440	dimerization interface [polypeptide binding]; other site
665571000441	DNA repair protein RadA; Provisional; Region: PRK11823
665571000442	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
665571000443	Walker A motif; other site
665571000444	ATP binding site [chemical binding]; other site
665571000445	Walker B motif; other site
665571000446	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
665571000447	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
665571000448	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
665571000449	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
665571000450	thiamine phosphate binding site [chemical binding]; other site
665571000451	active site
665571000452	pyrophosphate binding site [ion binding]; other site
665571000453	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
665571000454	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
665571000455	ATP binding site [chemical binding]; other site
665571000456	substrate interface [chemical binding]; other site
665571000457	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
665571000458	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571000459	FeS/SAM binding site; other site
665571000460	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
665571000461	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
665571000462	ThiS interaction site; other site
665571000463	putative active site [active]
665571000464	tetramer interface [polypeptide binding]; other site
665571000465	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
665571000466	thiS-thiF/thiG interaction site; other site
665571000467	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
665571000468	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
665571000469	putative ligand binding site [chemical binding]; other site
665571000470	putative NAD binding site [chemical binding]; other site
665571000471	putative catalytic site [active]
665571000472	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
665571000473	L-serine binding site [chemical binding]; other site
665571000474	ACT domain interface; other site
665571000475	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
665571000476	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571000477	catalytic residue [active]
665571000478	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
665571000479	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
665571000480	CoA binding domain; Region: CoA_binding; pfam02629
665571000481	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
665571000482	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
665571000483	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
665571000484	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571000485	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
665571000486	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
665571000487	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
665571000488	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
665571000489	dimer interface [polypeptide binding]; other site
665571000490	anticodon binding site; other site
665571000491	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
665571000492	homodimer interface [polypeptide binding]; other site
665571000493	motif 1; other site
665571000494	active site
665571000495	motif 2; other site
665571000496	GAD domain; Region: GAD; pfam02938
665571000497	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
665571000498	motif 3; other site
665571000499	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
665571000500	Cation efflux family; Region: Cation_efflux; pfam01545
665571000501	Predicted methyltransferases [General function prediction only]; Region: COG0313
665571000502	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
665571000503	putative SAM binding site [chemical binding]; other site
665571000504	putative homodimer interface [polypeptide binding]; other site
665571000505	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
665571000506	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
665571000507	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
665571000508	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
665571000509	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
665571000510	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
665571000511	catalytic residues [active]
665571000512	HDOD domain; Region: HDOD; pfam08668
665571000513	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571000514	Zn2+ binding site [ion binding]; other site
665571000515	Mg2+ binding site [ion binding]; other site
665571000516	AAA domain; Region: AAA_32; pfam13654
665571000517	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
665571000518	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
665571000519	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
665571000520	putative active site [active]
665571000521	putative CoA binding site [chemical binding]; other site
665571000522	nudix motif; other site
665571000523	metal binding site [ion binding]; metal-binding site
665571000524	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
665571000525	putative FMN binding site [chemical binding]; other site
665571000526	serine hydroxymethyltransferase; Provisional; Region: PRK13580
665571000527	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
665571000528	dimer interface [polypeptide binding]; other site
665571000529	active site
665571000530	glycine-pyridoxal phosphate binding site [chemical binding]; other site
665571000531	folate binding site [chemical binding]; other site
665571000532	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
665571000533	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
665571000534	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
665571000535	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
665571000536	glycogen binding site [chemical binding]; other site
665571000537	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
665571000538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000539	binding surface
665571000540	TPR motif; other site
665571000541	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
665571000542	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
665571000543	homodimer interface [polypeptide binding]; other site
665571000544	substrate-cofactor binding pocket; other site
665571000545	catalytic residue [active]
665571000546	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
665571000547	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
665571000548	Substrate binding site; other site
665571000549	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
665571000550	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
665571000551	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
665571000552	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607
665571000553	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
665571000554	glutamine binding [chemical binding]; other site
665571000555	catalytic triad [active]
665571000556	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
665571000557	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
665571000558	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
665571000559	active site
665571000560	ribulose/triose binding site [chemical binding]; other site
665571000561	phosphate binding site [ion binding]; other site
665571000562	substrate (anthranilate) binding pocket [chemical binding]; other site
665571000563	product (indole) binding pocket [chemical binding]; other site
665571000564	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
665571000565	active site
665571000566	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
665571000567	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
665571000568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571000569	catalytic residue [active]
665571000570	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
665571000571	substrate binding site [chemical binding]; other site
665571000572	active site
665571000573	catalytic residues [active]
665571000574	heterodimer interface [polypeptide binding]; other site
665571000575	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
665571000576	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
665571000577	catalytic residues [active]
665571000578	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
665571000579	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
665571000580	ligand binding site [chemical binding]; other site
665571000581	flexible hinge region; other site
665571000582	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
665571000583	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
665571000584	glutaminase active site [active]
665571000585	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
665571000586	dimer interface [polypeptide binding]; other site
665571000587	active site
665571000588	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
665571000589	dimer interface [polypeptide binding]; other site
665571000590	active site
665571000591	Integrin, beta chain; Region: Integrin_beta; cl17693
665571000592	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
665571000593	Protein of unknown function (DUF554); Region: DUF554; pfam04474
665571000594	homoserine dehydrogenase; Provisional; Region: PRK06349
665571000595	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
665571000596	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
665571000597	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
665571000598	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
665571000599	FecR protein; Region: FecR; pfam04773
665571000600	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
665571000601	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
665571000602	Walker A/P-loop; other site
665571000603	ATP binding site [chemical binding]; other site
665571000604	Q-loop/lid; other site
665571000605	ABC transporter signature motif; other site
665571000606	Walker B; other site
665571000607	D-loop; other site
665571000608	H-loop/switch region; other site
665571000609	TOBE domain; Region: TOBE_2; pfam08402
665571000610	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
665571000611	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
665571000612	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
665571000613	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000614	dimer interface [polypeptide binding]; other site
665571000615	putative CheW interface [polypeptide binding]; other site
665571000616	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
665571000617	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
665571000618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571000619	homodimer interface [polypeptide binding]; other site
665571000620	catalytic residue [active]
665571000621	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
665571000622	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571000623	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571000624	FtsX-like permease family; Region: FtsX; pfam02687
665571000625	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571000626	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571000627	FtsX-like permease family; Region: FtsX; pfam02687
665571000628	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571000629	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
665571000630	Walker A/P-loop; other site
665571000631	ATP binding site [chemical binding]; other site
665571000632	Q-loop/lid; other site
665571000633	ABC transporter signature motif; other site
665571000634	Walker B; other site
665571000635	D-loop; other site
665571000636	H-loop/switch region; other site
665571000637	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571000638	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571000639	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
665571000640	oligomerization interface [polypeptide binding]; other site
665571000641	active site
665571000642	metal binding site [ion binding]; metal-binding site
665571000643	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
665571000644	Flavoprotein; Region: Flavoprotein; pfam02441
665571000645	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
665571000646	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
665571000647	tetramerization interface [polypeptide binding]; other site
665571000648	active site
665571000649	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
665571000650	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
665571000651	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
665571000652	substrate binding pocket [chemical binding]; other site
665571000653	dimer interface [polypeptide binding]; other site
665571000654	inhibitor binding site; inhibition site
665571000655	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
665571000656	B12 binding site [chemical binding]; other site
665571000657	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
665571000658	hypothetical protein; Provisional; Region: PRK13761
665571000659	Predicted archaeal kinase (sugar kinase superfamily) [General function prediction only]; Region: COG1829
665571000660	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
665571000661	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
665571000662	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000663	putative CheW interface [polypeptide binding]; other site
665571000664	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
665571000665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571000666	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571000667	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571000668	dimer interface [polypeptide binding]; other site
665571000669	phosphorylation site [posttranslational modification]
665571000670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571000671	ATP binding site [chemical binding]; other site
665571000672	Mg2+ binding site [ion binding]; other site
665571000673	G-X-G motif; other site
665571000674	Response regulator receiver domain; Region: Response_reg; pfam00072
665571000675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000676	active site
665571000677	phosphorylation site [posttranslational modification]
665571000678	intermolecular recognition site; other site
665571000679	dimerization interface [polypeptide binding]; other site
665571000680	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
665571000681	putative binding surface; other site
665571000682	active site
665571000683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571000684	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571000685	putative substrate translocation pore; other site
665571000686	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
665571000687	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
665571000688	homotrimer interaction site [polypeptide binding]; other site
665571000689	putative active site [active]
665571000690	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
665571000691	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
665571000692	anti sigma factor interaction site; other site
665571000693	regulatory phosphorylation site [posttranslational modification]; other site
665571000694	Membrane transport protein; Region: Mem_trans; cl09117
665571000695	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
665571000696	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
665571000697	DNA binding site [nucleotide binding]
665571000698	active site
665571000699	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
665571000700	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
665571000701	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
665571000702	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
665571000703	active site
665571000704	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
665571000705	TSCPD domain; Region: TSCPD; pfam12637
665571000706	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
665571000707	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
665571000708	non-heme iron binding site [ion binding]; other site
665571000709	tetramer interface [polypeptide binding]; other site
665571000710	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
665571000711	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
665571000712	putative active site [active]
665571000713	PhoH-like protein; Region: PhoH; pfam02562
665571000714	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
665571000715	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
665571000716	NodB motif; other site
665571000717	active site
665571000718	catalytic site [active]
665571000719	metal binding site [ion binding]; metal-binding site
665571000720	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
665571000721	FlgN protein; Region: FlgN; pfam05130
665571000722	DNA polymerase I; Provisional; Region: PRK05755
665571000723	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
665571000724	active site
665571000725	metal binding site 1 [ion binding]; metal-binding site
665571000726	putative 5' ssDNA interaction site; other site
665571000727	metal binding site 3; metal-binding site
665571000728	metal binding site 2 [ion binding]; metal-binding site
665571000729	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
665571000730	putative DNA binding site [nucleotide binding]; other site
665571000731	putative metal binding site [ion binding]; other site
665571000732	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
665571000733	active site
665571000734	catalytic site [active]
665571000735	substrate binding site [chemical binding]; other site
665571000736	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
665571000737	active site
665571000738	DNA binding site [nucleotide binding]
665571000739	catalytic site [active]
665571000740	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
665571000741	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
665571000742	active site
665571000743	Sporulation related domain; Region: SPOR; pfam05036
665571000744	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
665571000745	serine O-acetyltransferase; Region: cysE; TIGR01172
665571000746	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
665571000747	trimer interface [polypeptide binding]; other site
665571000748	active site
665571000749	substrate binding site [chemical binding]; other site
665571000750	CoA binding site [chemical binding]; other site
665571000751	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
665571000752	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
665571000753	active site
665571000754	nucleophile elbow; other site
665571000755	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571000756	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
665571000757	ligand binding site [chemical binding]; other site
665571000758	dimerization interface [polypeptide binding]; other site
665571000759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000760	dimer interface [polypeptide binding]; other site
665571000761	putative CheW interface [polypeptide binding]; other site
665571000762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000763	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571000764	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000765	dimer interface [polypeptide binding]; other site
665571000766	putative CheW interface [polypeptide binding]; other site
665571000767	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
665571000768	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
665571000769	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
665571000770	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
665571000771	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571000772	putative DNA binding site [nucleotide binding]; other site
665571000773	putative Zn2+ binding site [ion binding]; other site
665571000774	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
665571000775	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
665571000776	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
665571000777	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
665571000778	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
665571000779	metal binding site [ion binding]; metal-binding site
665571000780	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
665571000781	active site
665571000782	catalytic residues [active]
665571000783	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
665571000784	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
665571000785	active site
665571000786	ADP/pyrophosphate binding site [chemical binding]; other site
665571000787	dimerization interface [polypeptide binding]; other site
665571000788	allosteric effector site; other site
665571000789	fructose-1,6-bisphosphate binding site; other site
665571000790	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
665571000791	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
665571000792	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
665571000793	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
665571000794	active site
665571000795	catalytic residues [active]
665571000796	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571000797	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571000798	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
665571000799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571000800	dimer interface [polypeptide binding]; other site
665571000801	conserved gate region; other site
665571000802	putative PBP binding loops; other site
665571000803	ABC-ATPase subunit interface; other site
665571000804	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571000805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571000806	dimer interface [polypeptide binding]; other site
665571000807	conserved gate region; other site
665571000808	putative PBP binding loops; other site
665571000809	ABC-ATPase subunit interface; other site
665571000810	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
665571000811	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
665571000812	putative active site [active]
665571000813	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571000814	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571000815	dimer interface [polypeptide binding]; other site
665571000816	putative CheW interface [polypeptide binding]; other site
665571000817	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
665571000818	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
665571000819	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
665571000820	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
665571000821	active site
665571000822	ADP/pyrophosphate binding site [chemical binding]; other site
665571000823	dimerization interface [polypeptide binding]; other site
665571000824	allosteric effector site; other site
665571000825	fructose-1,6-bisphosphate binding site; other site
665571000826	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
665571000827	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
665571000828	active site
665571000829	metal binding site [ion binding]; metal-binding site
665571000830	peroxiredoxin; Provisional; Region: PRK13189
665571000831	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
665571000832	dimer interface [polypeptide binding]; other site
665571000833	decamer (pentamer of dimers) interface [polypeptide binding]; other site
665571000834	catalytic triad [active]
665571000835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571000836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571000837	ATP binding site [chemical binding]; other site
665571000838	Mg2+ binding site [ion binding]; other site
665571000839	G-X-G motif; other site
665571000840	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571000841	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571000842	dimerization interface [polypeptide binding]; other site
665571000843	ligand binding site [chemical binding]; other site
665571000844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571000845	PAS fold; Region: PAS; pfam00989
665571000846	putative active site [active]
665571000847	heme pocket [chemical binding]; other site
665571000848	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
665571000849	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
665571000850	DNA binding residues [nucleotide binding]
665571000851	prolyl-tRNA synthetase; Provisional; Region: PRK09194
665571000852	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
665571000853	motif 1; other site
665571000854	dimer interface [polypeptide binding]; other site
665571000855	active site
665571000856	motif 2; other site
665571000857	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
665571000858	putative deacylase active site [active]
665571000859	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
665571000860	active site
665571000861	motif 3; other site
665571000862	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
665571000863	anticodon binding site; other site
665571000864	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
665571000865	Phosphate acyltransferases; Region: PlsC; smart00563
665571000866	putative acyl-acceptor binding pocket; other site
665571000867	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
665571000868	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
665571000869	peptide binding site [polypeptide binding]; other site
665571000870	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
665571000871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571000872	dimer interface [polypeptide binding]; other site
665571000873	conserved gate region; other site
665571000874	putative PBP binding loops; other site
665571000875	ABC-ATPase subunit interface; other site
665571000876	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
665571000877	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
665571000878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571000879	dimer interface [polypeptide binding]; other site
665571000880	conserved gate region; other site
665571000881	putative PBP binding loops; other site
665571000882	ABC-ATPase subunit interface; other site
665571000883	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
665571000884	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
665571000885	Walker A/P-loop; other site
665571000886	ATP binding site [chemical binding]; other site
665571000887	Q-loop/lid; other site
665571000888	ABC transporter signature motif; other site
665571000889	Walker B; other site
665571000890	D-loop; other site
665571000891	H-loop/switch region; other site
665571000892	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
665571000893	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
665571000894	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
665571000895	Walker A/P-loop; other site
665571000896	ATP binding site [chemical binding]; other site
665571000897	Q-loop/lid; other site
665571000898	ABC transporter signature motif; other site
665571000899	Walker B; other site
665571000900	D-loop; other site
665571000901	H-loop/switch region; other site
665571000902	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
665571000903	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
665571000904	glutamine synthetase, type I; Region: GlnA; TIGR00653
665571000905	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
665571000906	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
665571000907	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
665571000908	peptidase T; Region: peptidase-T; TIGR01882
665571000909	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
665571000910	metal binding site [ion binding]; metal-binding site
665571000911	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
665571000912	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
665571000913	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
665571000914	trmE is a tRNA modification GTPase; Region: trmE; cd04164
665571000915	G1 box; other site
665571000916	GTP/Mg2+ binding site [chemical binding]; other site
665571000917	Switch I region; other site
665571000918	G2 box; other site
665571000919	Switch II region; other site
665571000920	G3 box; other site
665571000921	G4 box; other site
665571000922	G5 box; other site
665571000923	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
665571000924	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
665571000925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
665571000926	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
665571000927	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
665571000928	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
665571000929	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
665571000930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000931	TPR motif; other site
665571000932	binding surface
665571000933	TPR repeat; Region: TPR_11; pfam13414
665571000934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000935	TPR motif; other site
665571000936	binding surface
665571000937	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571000938	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571000939	binding surface
665571000940	TPR motif; other site
665571000941	Restriction endonuclease; Region: Mrr_cat; pfam04471
665571000942	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571000943	metal binding site [ion binding]; metal-binding site
665571000944	active site
665571000945	I-site; other site
665571000946	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
665571000947	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
665571000948	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
665571000949	active site
665571000950	catalytic residue [active]
665571000951	dimer interface [polypeptide binding]; other site
665571000952	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
665571000953	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
665571000954	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
665571000955	shikimate binding site; other site
665571000956	NAD(P) binding site [chemical binding]; other site
665571000957	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
665571000958	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
665571000959	NAD(P) binding pocket [chemical binding]; other site
665571000960	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
665571000961	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
665571000962	dimer interface [polypeptide binding]; other site
665571000963	active site
665571000964	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
665571000965	catalytic residues [active]
665571000966	substrate binding site [chemical binding]; other site
665571000967	agmatinase; Region: agmatinase; TIGR01230
665571000968	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
665571000969	putative active site [active]
665571000970	Mn binding site [ion binding]; other site
665571000971	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
665571000972	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
665571000973	acyl-activating enzyme (AAE) consensus motif; other site
665571000974	putative AMP binding site [chemical binding]; other site
665571000975	putative active site [active]
665571000976	putative CoA binding site [chemical binding]; other site
665571000977	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
665571000978	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571000979	Walker A/P-loop; other site
665571000980	ATP binding site [chemical binding]; other site
665571000981	Q-loop/lid; other site
665571000982	ABC transporter signature motif; other site
665571000983	Walker B; other site
665571000984	D-loop; other site
665571000985	H-loop/switch region; other site
665571000986	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
665571000987	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
665571000988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571000989	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
665571000990	ATP binding site [chemical binding]; other site
665571000991	Mg2+ binding site [ion binding]; other site
665571000992	G-X-G motif; other site
665571000993	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
665571000994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571000995	active site
665571000996	phosphorylation site [posttranslational modification]
665571000997	intermolecular recognition site; other site
665571000998	dimerization interface [polypeptide binding]; other site
665571000999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571001000	Walker A motif; other site
665571001001	ATP binding site [chemical binding]; other site
665571001002	Walker B motif; other site
665571001003	arginine finger; other site
665571001004	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
665571001005	Omptin family; Region: Omptin; cl01886
665571001006	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
665571001007	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
665571001008	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
665571001009	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
665571001010	ATP binding site [chemical binding]; other site
665571001011	putative Mg++ binding site [ion binding]; other site
665571001012	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
665571001013	nucleotide binding region [chemical binding]; other site
665571001014	ATP-binding site [chemical binding]; other site
665571001015	lipoyl synthase; Provisional; Region: PRK05481
665571001016	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571001017	FeS/SAM binding site; other site
665571001018	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
665571001019	FMN-binding domain; Region: FMN_bind; cl01081
665571001020	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
665571001021	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
665571001022	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
665571001023	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
665571001024	catalytic loop [active]
665571001025	iron binding site [ion binding]; other site
665571001026	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
665571001027	FAD binding pocket [chemical binding]; other site
665571001028	conserved FAD binding motif [chemical binding]; other site
665571001029	phosphate binding motif [ion binding]; other site
665571001030	beta-alpha-beta structure motif; other site
665571001031	NAD binding pocket [chemical binding]; other site
665571001032	HEPN domain; Region: HEPN; pfam05168
665571001033	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
665571001034	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
665571001035	putative active site [active]
665571001036	catalytic triad [active]
665571001037	putative dimer interface [polypeptide binding]; other site
665571001038	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571001039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571001040	Walker A/P-loop; other site
665571001041	ATP binding site [chemical binding]; other site
665571001042	Q-loop/lid; other site
665571001043	ABC transporter signature motif; other site
665571001044	Walker B; other site
665571001045	D-loop; other site
665571001046	H-loop/switch region; other site
665571001047	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
665571001048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571001049	putative active site [active]
665571001050	heme pocket [chemical binding]; other site
665571001051	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
665571001052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571001053	ATP binding site [chemical binding]; other site
665571001054	Mg2+ binding site [ion binding]; other site
665571001055	G-X-G motif; other site
665571001056	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
665571001057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001058	active site
665571001059	phosphorylation site [posttranslational modification]
665571001060	intermolecular recognition site; other site
665571001061	dimerization interface [polypeptide binding]; other site
665571001062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571001063	Walker A motif; other site
665571001064	ATP binding site [chemical binding]; other site
665571001065	Walker B motif; other site
665571001066	arginine finger; other site
665571001067	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
665571001068	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
665571001069	putative ligand binding site [chemical binding]; other site
665571001070	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
665571001071	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
665571001072	Walker A/P-loop; other site
665571001073	ATP binding site [chemical binding]; other site
665571001074	Q-loop/lid; other site
665571001075	ABC transporter signature motif; other site
665571001076	Walker B; other site
665571001077	D-loop; other site
665571001078	H-loop/switch region; other site
665571001079	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
665571001080	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571001081	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
665571001082	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
665571001083	TM-ABC transporter signature motif; other site
665571001084	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
665571001085	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
665571001086	active site
665571001087	HIGH motif; other site
665571001088	KMSKS motif; other site
665571001089	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
665571001090	tRNA binding surface [nucleotide binding]; other site
665571001091	anticodon binding site; other site
665571001092	Putative tRNA binding domain; Region: tRNA_bind; pfam01588
665571001093	putative tRNA-binding site [nucleotide binding]; other site
665571001094	FemAB family; Region: FemAB; pfam02388
665571001095	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
665571001096	FemAB family; Region: FemAB; pfam02388
665571001097	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
665571001098	structural tetrad; other site
665571001099	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
665571001100	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
665571001101	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
665571001102	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
665571001103	AMMECR1; Region: AMMECR1; pfam01871
665571001104	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
665571001105	putative ligand binding pocket/active site [active]
665571001106	putative metal binding site [ion binding]; other site
665571001107	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
665571001108	Domain of unknown function (DUF814); Region: DUF814; pfam05670
665571001109	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
665571001110	histidinol dehydrogenase; Region: hisD; TIGR00069
665571001111	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
665571001112	NAD binding site [chemical binding]; other site
665571001113	dimerization interface [polypeptide binding]; other site
665571001114	product binding site; other site
665571001115	substrate binding site [chemical binding]; other site
665571001116	zinc binding site [ion binding]; other site
665571001117	catalytic residues [active]
665571001118	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
665571001119	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
665571001120	active site
665571001121	catalytic residues [active]
665571001122	metal binding site [ion binding]; metal-binding site
665571001123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
665571001124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001125	dimer interface [polypeptide binding]; other site
665571001126	conserved gate region; other site
665571001127	ABC-ATPase subunit interface; other site
665571001128	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
665571001129	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
665571001130	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
665571001131	dimer interface [polypeptide binding]; other site
665571001132	[2Fe-2S] cluster binding site [ion binding]; other site
665571001133	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
665571001134	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571001135	FeS/SAM binding site; other site
665571001136	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
665571001137	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
665571001138	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
665571001139	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
665571001140	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
665571001141	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
665571001142	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
665571001143	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
665571001144	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
665571001145	Nitrogen regulatory protein P-II; Region: P-II; smart00938
665571001146	Nitrogen regulatory protein P-II; Region: P-II; smart00938
665571001147	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
665571001148	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
665571001149	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
665571001150	Nucleotide-binding sites [chemical binding]; other site
665571001151	Walker A motif; other site
665571001152	Switch I region of nucleotide binding site; other site
665571001153	Fe4S4 binding sites [ion binding]; other site
665571001154	Switch II region of nucleotide binding site; other site
665571001155	TIGR03545 family protein; Region: TIGR03545
665571001156	TIGR03546 family protein; Region: TIGR03546
665571001157	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
665571001158	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
665571001159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571001160	ABC transporter signature motif; other site
665571001161	Walker B; other site
665571001162	D-loop; other site
665571001163	ammonium transporter; Region: amt; TIGR00836
665571001164	dimerization interface [polypeptide binding]; other site
665571001165	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
665571001166	PAS fold; Region: PAS; pfam00989
665571001167	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
665571001168	putative binding surface; other site
665571001169	active site
665571001170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571001171	ATP binding site [chemical binding]; other site
665571001172	Mg2+ binding site [ion binding]; other site
665571001173	G-X-G motif; other site
665571001174	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
665571001175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001176	Response regulator receiver domain; Region: Response_reg; pfam00072
665571001177	active site
665571001178	phosphorylation site [posttranslational modification]
665571001179	intermolecular recognition site; other site
665571001180	dimerization interface [polypeptide binding]; other site
665571001181	Uncharacterized conserved protein [Function unknown]; Region: COG0432
665571001182	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
665571001183	nucleotide binding site/active site [active]
665571001184	HIT family signature motif; other site
665571001185	catalytic residue [active]
665571001186	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
665571001187	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
665571001188	hinge; other site
665571001189	active site
665571001190	PAS fold; Region: PAS_4; pfam08448
665571001191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571001192	putative active site [active]
665571001193	heme pocket [chemical binding]; other site
665571001194	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571001195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571001196	metal binding site [ion binding]; metal-binding site
665571001197	active site
665571001198	I-site; other site
665571001199	Chemotaxis phosphatase CheX; Region: CheX; cl15816
665571001200	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
665571001201	Response regulator receiver domain; Region: Response_reg; pfam00072
665571001202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001203	active site
665571001204	phosphorylation site [posttranslational modification]
665571001205	intermolecular recognition site; other site
665571001206	dimerization interface [polypeptide binding]; other site
665571001207	Helix-turn-helix domain; Region: HTH_17; pfam12728
665571001208	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
665571001209	active site
665571001210	phosphorylation site [posttranslational modification]
665571001211	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
665571001212	active site
665571001213	phosphorylation site [posttranslational modification]
665571001214	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
665571001215	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
665571001216	FOG: CBS domain [General function prediction only]; Region: COG0517
665571001217	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
665571001218	Predicted transcriptional regulator [Transcription]; Region: COG2378
665571001219	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571001220	putative DNA binding site [nucleotide binding]; other site
665571001221	putative Zn2+ binding site [ion binding]; other site
665571001222	WYL domain; Region: WYL; pfam13280
665571001223	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
665571001224	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
665571001225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
665571001226	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
665571001227	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
665571001228	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
665571001229	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
665571001230	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
665571001231	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
665571001232	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
665571001233	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
665571001234	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
665571001235	HIGH motif; other site
665571001236	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
665571001237	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
665571001238	active site
665571001239	KMSKS motif; other site
665571001240	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
665571001241	tRNA binding surface [nucleotide binding]; other site
665571001242	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571001243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001244	dimer interface [polypeptide binding]; other site
665571001245	conserved gate region; other site
665571001246	ABC-ATPase subunit interface; other site
665571001247	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571001248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001249	dimer interface [polypeptide binding]; other site
665571001250	conserved gate region; other site
665571001251	putative PBP binding loops; other site
665571001252	ABC-ATPase subunit interface; other site
665571001253	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571001254	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
665571001255	Helix-turn-helix domain; Region: HTH_18; pfam12833
665571001256	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
665571001257	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
665571001258	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
665571001259	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
665571001260	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
665571001261	NAD binding site [chemical binding]; other site
665571001262	homodimer interface [polypeptide binding]; other site
665571001263	active site
665571001264	substrate binding site [chemical binding]; other site
665571001265	tartrate dehydrogenase; Region: TTC; TIGR02089
665571001266	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
665571001267	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
665571001268	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
665571001269	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
665571001270	catalytic site [active]
665571001271	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
665571001272	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
665571001273	dimer interface [polypeptide binding]; other site
665571001274	active site
665571001275	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
665571001276	mevalonate kinase; Region: mevalon_kin; TIGR00549
665571001277	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
665571001278	putative alpha-glucosidase; Provisional; Region: PRK10658
665571001279	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
665571001280	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
665571001281	active site
665571001282	homotrimer interface [polypeptide binding]; other site
665571001283	catalytic site [active]
665571001284	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
665571001285	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
665571001286	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
665571001287	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
665571001288	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
665571001289	PKC phosphorylation site [posttranslational modification]; other site
665571001290	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
665571001291	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
665571001292	Cupin domain; Region: Cupin_2; pfam07883
665571001293	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571001294	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
665571001295	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571001296	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571001297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001298	dimer interface [polypeptide binding]; other site
665571001299	conserved gate region; other site
665571001300	ABC-ATPase subunit interface; other site
665571001301	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571001302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001303	dimer interface [polypeptide binding]; other site
665571001304	conserved gate region; other site
665571001305	ABC-ATPase subunit interface; other site
665571001306	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571001307	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571001308	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
665571001309	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
665571001310	Pectate lyase; Region: Pec_lyase_C; cl01593
665571001311	Right handed beta helix region; Region: Beta_helix; pfam13229
665571001312	Cache domain; Region: Cache_1; pfam02743
665571001313	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571001314	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571001315	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571001316	dimer interface [polypeptide binding]; other site
665571001317	putative CheW interface [polypeptide binding]; other site
665571001318	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
665571001319	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
665571001320	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
665571001321	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
665571001322	NADP binding site [chemical binding]; other site
665571001323	homodimer interface [polypeptide binding]; other site
665571001324	active site
665571001325	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
665571001326	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
665571001327	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
665571001328	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
665571001329	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
665571001330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
665571001331	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
665571001332	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
665571001333	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
665571001334	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
665571001335	DctM-like transporters; Region: DctM; pfam06808
665571001336	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
665571001337	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
665571001338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571001339	NAD(P) binding site [chemical binding]; other site
665571001340	active site
665571001341	Transcriptional regulators [Transcription]; Region: GntR; COG1802
665571001342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
665571001343	DNA-binding site [nucleotide binding]; DNA binding site
665571001344	FCD domain; Region: FCD; pfam07729
665571001345	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
665571001346	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
665571001347	ligand binding site [chemical binding]; other site
665571001348	NAD binding site [chemical binding]; other site
665571001349	catalytic site [active]
665571001350	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
665571001351	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
665571001352	active site
665571001353	catalytic tetrad [active]
665571001354	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571001355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571001356	HEAT repeats; Region: HEAT_2; pfam13646
665571001357	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571001358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001359	dimer interface [polypeptide binding]; other site
665571001360	conserved gate region; other site
665571001361	putative PBP binding loops; other site
665571001362	ABC-ATPase subunit interface; other site
665571001363	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571001364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001365	dimer interface [polypeptide binding]; other site
665571001366	conserved gate region; other site
665571001367	ABC-ATPase subunit interface; other site
665571001368	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571001369	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571001370	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
665571001371	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
665571001372	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
665571001373	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
665571001374	substrate binding site [chemical binding]; other site
665571001375	ATP binding site [chemical binding]; other site
665571001376	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
665571001377	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
665571001378	active site
665571001379	intersubunit interface [polypeptide binding]; other site
665571001380	catalytic residue [active]
665571001381	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
665571001382	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
665571001383	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
665571001384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571001385	binding surface
665571001386	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571001387	TPR motif; other site
665571001388	AAA domain; Region: AAA_17; pfam13207
665571001389	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
665571001390	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
665571001391	RNA binding surface [nucleotide binding]; other site
665571001392	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
665571001393	active site
665571001394	Divergent PAP2 family; Region: DUF212; pfam02681
665571001395	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
665571001396	SLBB domain; Region: SLBB; pfam10531
665571001397	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
665571001398	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
665571001399	catalytic motif [active]
665571001400	Zn binding site [ion binding]; other site
665571001401	RibD C-terminal domain; Region: RibD_C; cl17279
665571001402	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
665571001403	Lumazine binding domain; Region: Lum_binding; pfam00677
665571001404	Lumazine binding domain; Region: Lum_binding; pfam00677
665571001405	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
665571001406	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
665571001407	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
665571001408	dimerization interface [polypeptide binding]; other site
665571001409	active site
665571001410	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
665571001411	homopentamer interface [polypeptide binding]; other site
665571001412	active site
665571001413	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
665571001414	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
665571001415	phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
665571001416	active site
665571001417	ATP binding site [chemical binding]; other site
665571001418	substrate binding site [chemical binding]; other site
665571001419	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
665571001420	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571001421	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
665571001422	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
665571001423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571001424	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
665571001425	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571001426	DNA binding residues [nucleotide binding]
665571001427	pyruvate phosphate dikinase; Provisional; Region: PRK09279
665571001428	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
665571001429	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
665571001430	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
665571001431	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
665571001432	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
665571001433	minor groove reading motif; other site
665571001434	helix-hairpin-helix signature motif; other site
665571001435	substrate binding pocket [chemical binding]; other site
665571001436	active site
665571001437	D-mannonate oxidoreductase; Provisional; Region: PRK08277
665571001438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571001439	NAD(P) binding site [chemical binding]; other site
665571001440	active site
665571001441	Glucuronate isomerase; Region: UxaC; pfam02614
665571001442	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
665571001443	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
665571001444	Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384
665571001445	catalytic core domain of  class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674
665571001446	active site
665571001447	HIGH motif; other site
665571001448	KMSKS motif; other site
665571001449	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
665571001450	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
665571001451	active site
665571001452	PHP-associated; Region: PHP_C; pfam13263
665571001453	PAS domain; Region: PAS; smart00091
665571001454	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571001455	metal binding site [ion binding]; metal-binding site
665571001456	active site
665571001457	I-site; other site
665571001458	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
665571001459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001460	Response regulator receiver domain; Region: Response_reg; pfam00072
665571001461	active site
665571001462	phosphorylation site [posttranslational modification]
665571001463	intermolecular recognition site; other site
665571001464	dimerization interface [polypeptide binding]; other site
665571001465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571001466	PAS domain; Region: PAS_9; pfam13426
665571001467	putative active site [active]
665571001468	heme pocket [chemical binding]; other site
665571001469	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571001470	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571001471	metal binding site [ion binding]; metal-binding site
665571001472	active site
665571001473	I-site; other site
665571001474	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
665571001475	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
665571001476	Rubrerythrin [Energy production and conversion]; Region: COG1592
665571001477	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
665571001478	binuclear metal center [ion binding]; other site
665571001479	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
665571001480	iron binding site [ion binding]; other site
665571001481	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
665571001482	Rubredoxin; Region: Rubredoxin; pfam00301
665571001483	iron binding site [ion binding]; other site
665571001484	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
665571001485	Low molecular weight phosphatase family; Region: LMWPc; cd00115
665571001486	active site
665571001487	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
665571001488	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
665571001489	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
665571001490	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
665571001491	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
665571001492	putative dimer interface [polypeptide binding]; other site
665571001493	putative anticodon binding site; other site
665571001494	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
665571001495	homodimer interface [polypeptide binding]; other site
665571001496	motif 1; other site
665571001497	motif 2; other site
665571001498	active site
665571001499	motif 3; other site
665571001500	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
665571001501	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
665571001502	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
665571001503	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
665571001504	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
665571001505	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
665571001506	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
665571001507	putative active site [active]
665571001508	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
665571001509	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
665571001510	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
665571001511	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
665571001512	putative homodimer interface [polypeptide binding]; other site
665571001513	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
665571001514	heterodimer interface [polypeptide binding]; other site
665571001515	homodimer interface [polypeptide binding]; other site
665571001516	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
665571001517	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
665571001518	putative thiostrepton binding site; other site
665571001519	23S rRNA interface [nucleotide binding]; other site
665571001520	L7/L12 interface [polypeptide binding]; other site
665571001521	L25 interface [polypeptide binding]; other site
665571001522	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
665571001523	mRNA/rRNA interface [nucleotide binding]; other site
665571001524	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
665571001525	23S rRNA interface [nucleotide binding]; other site
665571001526	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
665571001527	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
665571001528	core dimer interface [polypeptide binding]; other site
665571001529	peripheral dimer interface [polypeptide binding]; other site
665571001530	L10 interface [polypeptide binding]; other site
665571001531	L11 interface [polypeptide binding]; other site
665571001532	putative EF-Tu interaction site [polypeptide binding]; other site
665571001533	putative EF-G interaction site [polypeptide binding]; other site
665571001534	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
665571001535	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
665571001536	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
665571001537	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
665571001538	RPB1 interaction site [polypeptide binding]; other site
665571001539	RPB10 interaction site [polypeptide binding]; other site
665571001540	RPB11 interaction site [polypeptide binding]; other site
665571001541	RPB3 interaction site [polypeptide binding]; other site
665571001542	RPB12 interaction site [polypeptide binding]; other site
665571001543	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
665571001544	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
665571001545	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
665571001546	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
665571001547	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
665571001548	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
665571001549	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
665571001550	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
665571001551	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
665571001552	DNA binding site [nucleotide binding]
665571001553	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
665571001554	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
665571001555	S17 interaction site [polypeptide binding]; other site
665571001556	S8 interaction site; other site
665571001557	16S rRNA interaction site [nucleotide binding]; other site
665571001558	streptomycin interaction site [chemical binding]; other site
665571001559	23S rRNA interaction site [nucleotide binding]; other site
665571001560	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
665571001561	30S ribosomal protein S7; Validated; Region: PRK05302
665571001562	elongation factor Tu; Reviewed; Region: PRK00049
665571001563	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
665571001564	G1 box; other site
665571001565	GEF interaction site [polypeptide binding]; other site
665571001566	GTP/Mg2+ binding site [chemical binding]; other site
665571001567	Switch I region; other site
665571001568	G2 box; other site
665571001569	G3 box; other site
665571001570	Switch II region; other site
665571001571	G4 box; other site
665571001572	G5 box; other site
665571001573	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
665571001574	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
665571001575	Antibiotic Binding Site [chemical binding]; other site
665571001576	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
665571001577	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
665571001578	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
665571001579	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
665571001580	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
665571001581	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
665571001582	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
665571001583	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
665571001584	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
665571001585	putative translocon binding site; other site
665571001586	protein-rRNA interface [nucleotide binding]; other site
665571001587	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
665571001588	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
665571001589	G-X-X-G motif; other site
665571001590	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
665571001591	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
665571001592	23S rRNA interface [nucleotide binding]; other site
665571001593	5S rRNA interface [nucleotide binding]; other site
665571001594	putative antibiotic binding site [chemical binding]; other site
665571001595	L25 interface [polypeptide binding]; other site
665571001596	L27 interface [polypeptide binding]; other site
665571001597	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
665571001598	23S rRNA interface [nucleotide binding]; other site
665571001599	putative translocon interaction site; other site
665571001600	signal recognition particle (SRP54) interaction site; other site
665571001601	L23 interface [polypeptide binding]; other site
665571001602	trigger factor interaction site; other site
665571001603	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
665571001604	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
665571001605	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
665571001606	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
665571001607	RNA binding site [nucleotide binding]; other site
665571001608	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
665571001609	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
665571001610	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
665571001611	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
665571001612	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
665571001613	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
665571001614	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
665571001615	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
665571001616	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
665571001617	5S rRNA interface [nucleotide binding]; other site
665571001618	23S rRNA interface [nucleotide binding]; other site
665571001619	L5 interface [polypeptide binding]; other site
665571001620	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
665571001621	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
665571001622	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
665571001623	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
665571001624	23S rRNA binding site [nucleotide binding]; other site
665571001625	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
665571001626	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
665571001627	SecY translocase; Region: SecY; pfam00344
665571001628	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
665571001629	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
665571001630	30S ribosomal protein S13; Region: bact_S13; TIGR03631
665571001631	30S ribosomal protein S11; Validated; Region: PRK05309
665571001632	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
665571001633	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
665571001634	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
665571001635	RNA binding surface [nucleotide binding]; other site
665571001636	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
665571001637	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
665571001638	alphaNTD homodimer interface [polypeptide binding]; other site
665571001639	alphaNTD - beta interaction site [polypeptide binding]; other site
665571001640	alphaNTD - beta' interaction site [polypeptide binding]; other site
665571001641	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
665571001642	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
665571001643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571001644	S-adenosylmethionine binding site [chemical binding]; other site
665571001645	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
665571001646	RNA/DNA hybrid binding site [nucleotide binding]; other site
665571001647	active site
665571001648	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
665571001649	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
665571001650	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
665571001651	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
665571001652	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
665571001653	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
665571001654	protein binding site [polypeptide binding]; other site
665571001655	excinuclease ABC subunit B; Provisional; Region: PRK05298
665571001656	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
665571001657	ATP binding site [chemical binding]; other site
665571001658	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
665571001659	nucleotide binding region [chemical binding]; other site
665571001660	ATP-binding site [chemical binding]; other site
665571001661	Ultra-violet resistance protein B; Region: UvrB; pfam12344
665571001662	UvrB/uvrC motif; Region: UVR; pfam02151
665571001663	Bacterial SH3 domain; Region: SH3_4; pfam06347
665571001664	PBP superfamily domain; Region: PBP_like_2; cl17296
665571001665	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
665571001666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001667	dimer interface [polypeptide binding]; other site
665571001668	conserved gate region; other site
665571001669	putative PBP binding loops; other site
665571001670	ABC-ATPase subunit interface; other site
665571001671	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
665571001672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571001673	dimer interface [polypeptide binding]; other site
665571001674	conserved gate region; other site
665571001675	putative PBP binding loops; other site
665571001676	ABC-ATPase subunit interface; other site
665571001677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
665571001678	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
665571001679	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
665571001680	Walker A/P-loop; other site
665571001681	ATP binding site [chemical binding]; other site
665571001682	Q-loop/lid; other site
665571001683	ABC transporter signature motif; other site
665571001684	Walker B; other site
665571001685	D-loop; other site
665571001686	H-loop/switch region; other site
665571001687	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
665571001688	active site
665571001689	metal binding site [ion binding]; metal-binding site
665571001690	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
665571001691	Ca binding site [ion binding]; other site
665571001692	ligand binding site I [chemical binding]; other site
665571001693	homodimer interface [polypeptide binding]; other site
665571001694	ligand binding site II [chemical binding]; other site
665571001695	glycosyl hydrolase 64 family; Region: GH64-like; cd09214
665571001696	substrate binding pocket [chemical binding]; other site
665571001697	catalytic residues [active]
665571001698	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
665571001699	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571001700	putative active site [active]
665571001701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571001702	dimer interface [polypeptide binding]; other site
665571001703	phosphorylation site [posttranslational modification]
665571001704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571001705	ATP binding site [chemical binding]; other site
665571001706	Mg2+ binding site [ion binding]; other site
665571001707	G-X-G motif; other site
665571001708	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
665571001709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001710	active site
665571001711	phosphorylation site [posttranslational modification]
665571001712	intermolecular recognition site; other site
665571001713	dimerization interface [polypeptide binding]; other site
665571001714	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
665571001715	DNA binding site [nucleotide binding]
665571001716	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
665571001717	PhoU domain; Region: PhoU; pfam01895
665571001718	PhoU domain; Region: PhoU; pfam01895
665571001719	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
665571001720	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
665571001721	active site
665571001722	homodimer interface [polypeptide binding]; other site
665571001723	Colicin V production protein; Region: Colicin_V; pfam02674
665571001724	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
665571001725	DNA polymerase III subunit delta'; Validated; Region: PRK08485
665571001726	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
665571001727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571001728	dimer interface [polypeptide binding]; other site
665571001729	phosphorylation site [posttranslational modification]
665571001730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571001731	ATP binding site [chemical binding]; other site
665571001732	Mg2+ binding site [ion binding]; other site
665571001733	G-X-G motif; other site
665571001734	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
665571001735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001736	active site
665571001737	phosphorylation site [posttranslational modification]
665571001738	intermolecular recognition site; other site
665571001739	dimerization interface [polypeptide binding]; other site
665571001740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571001741	Walker A motif; other site
665571001742	ATP binding site [chemical binding]; other site
665571001743	Walker B motif; other site
665571001744	arginine finger; other site
665571001745	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
665571001746	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
665571001747	HSP70 interaction site [polypeptide binding]; other site
665571001748	aspartate kinase III; Validated; Region: PRK09084
665571001749	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
665571001750	putative catalytic residues [active]
665571001751	nucleotide binding site [chemical binding]; other site
665571001752	aspartate binding site [chemical binding]; other site
665571001753	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
665571001754	dimer interface [polypeptide binding]; other site
665571001755	allosteric regulatory binding pocket; other site
665571001756	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
665571001757	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
665571001758	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
665571001759	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
665571001760	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
665571001761	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
665571001762	oligomerisation interface [polypeptide binding]; other site
665571001763	mobile loop; other site
665571001764	roof hairpin; other site
665571001765	GTPase Era; Reviewed; Region: era; PRK00089
665571001766	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
665571001767	G1 box; other site
665571001768	GTP/Mg2+ binding site [chemical binding]; other site
665571001769	Switch I region; other site
665571001770	G2 box; other site
665571001771	Switch II region; other site
665571001772	G3 box; other site
665571001773	G4 box; other site
665571001774	G5 box; other site
665571001775	ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512
665571001776	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
665571001777	oligomer interface [polypeptide binding]; other site
665571001778	active site residues [active]
665571001779	putative catalytic site [active]
665571001780	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
665571001781	putative metal binding site [ion binding]; other site
665571001782	putative phosphate binding site [ion binding]; other site
665571001783	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
665571001784	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
665571001785	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
665571001786	putative ligand binding site [chemical binding]; other site
665571001787	putative NAD binding site [chemical binding]; other site
665571001788	catalytic site [active]
665571001789	mannonate dehydratase; Provisional; Region: PRK03906
665571001790	mannonate dehydratase; Region: uxuA; TIGR00695
665571001791	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571001792	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571001793	metal binding site [ion binding]; metal-binding site
665571001794	active site
665571001795	I-site; other site
665571001796	Response regulator receiver domain; Region: Response_reg; pfam00072
665571001797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001798	active site
665571001799	phosphorylation site [posttranslational modification]
665571001800	intermolecular recognition site; other site
665571001801	dimerization interface [polypeptide binding]; other site
665571001802	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
665571001803	ATP binding site [chemical binding]; other site
665571001804	G-X-G motif; other site
665571001805	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
665571001806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571001807	putative active site [active]
665571001808	heme pocket [chemical binding]; other site
665571001809	PAS fold; Region: PAS_4; pfam08448
665571001810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571001811	PAS domain; Region: PAS_9; pfam13426
665571001812	putative active site [active]
665571001813	heme pocket [chemical binding]; other site
665571001814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571001815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571001816	dimer interface [polypeptide binding]; other site
665571001817	phosphorylation site [posttranslational modification]
665571001818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571001819	ATP binding site [chemical binding]; other site
665571001820	Mg2+ binding site [ion binding]; other site
665571001821	G-X-G motif; other site
665571001822	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571001823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571001824	active site
665571001825	phosphorylation site [posttranslational modification]
665571001826	intermolecular recognition site; other site
665571001827	dimerization interface [polypeptide binding]; other site
665571001828	arginine decarboxylase; Provisional; Region: PRK05354
665571001829	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
665571001830	dimer interface [polypeptide binding]; other site
665571001831	active site
665571001832	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
665571001833	catalytic residues [active]
665571001834	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
665571001835	Chromate transporter; Region: Chromate_transp; pfam02417
665571001836	Chromate transporter; Region: Chromate_transp; pfam02417
665571001837	Transcriptional regulator; Region: Rrf2; pfam02082
665571001838	Predicted transcriptional regulator [Transcription]; Region: COG1959
665571001839	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
665571001840	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
665571001841	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
665571001842	Walker A/P-loop; other site
665571001843	ATP binding site [chemical binding]; other site
665571001844	Q-loop/lid; other site
665571001845	ABC transporter signature motif; other site
665571001846	Walker B; other site
665571001847	D-loop; other site
665571001848	H-loop/switch region; other site
665571001849	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
665571001850	FeS assembly protein SufB; Region: sufB; TIGR01980
665571001851	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
665571001852	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
665571001853	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
665571001854	[2Fe-2S] cluster binding site [ion binding]; other site
665571001855	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
665571001856	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
665571001857	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571001858	catalytic residue [active]
665571001859	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
665571001860	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
665571001861	trimerization site [polypeptide binding]; other site
665571001862	active site
665571001863	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
665571001864	DHH family; Region: DHH; pfam01368
665571001865	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
665571001866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571001867	NAD(P) binding site [chemical binding]; other site
665571001868	active site
665571001869	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
665571001870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571001871	Walker A motif; other site
665571001872	ATP binding site [chemical binding]; other site
665571001873	Walker B motif; other site
665571001874	arginine finger; other site
665571001875	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
665571001876	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
665571001877	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
665571001878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571001879	Walker A motif; other site
665571001880	ATP binding site [chemical binding]; other site
665571001881	Walker B motif; other site
665571001882	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
665571001883	Clp protease; Region: CLP_protease; pfam00574
665571001884	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
665571001885	oligomer interface [polypeptide binding]; other site
665571001886	active site residues [active]
665571001887	trigger factor; Provisional; Region: tig; PRK01490
665571001888	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
665571001889	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
665571001890	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571001891	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
665571001892	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
665571001893	ADP binding site [chemical binding]; other site
665571001894	magnesium binding site [ion binding]; other site
665571001895	putative shikimate binding site; other site
665571001896	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
665571001897	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
665571001898	Tetramer interface [polypeptide binding]; other site
665571001899	active site
665571001900	FMN-binding site [chemical binding]; other site
665571001901	Transcriptional regulators [Transcription]; Region: GntR; COG1802
665571001902	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
665571001903	DNA-binding site [nucleotide binding]; DNA binding site
665571001904	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
665571001905	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
665571001906	catalytic residue [active]
665571001907	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
665571001908	dimer interface [polypeptide binding]; other site
665571001909	active site
665571001910	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
665571001911	substrate binding site [chemical binding]; other site
665571001912	catalytic residues [active]
665571001913	ornithine carbamoyltransferase; Validated; Region: PRK02102
665571001914	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
665571001915	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
665571001916	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
665571001917	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
665571001918	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
665571001919	PhoU domain; Region: PhoU; pfam01895
665571001920	PhoU domain; Region: PhoU; pfam01895
665571001921	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
665571001922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571001923	Walker A motif; other site
665571001924	ATP binding site [chemical binding]; other site
665571001925	Walker B motif; other site
665571001926	arginine finger; other site
665571001927	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
665571001928	Methyltransferase domain; Region: Methyltransf_31; pfam13847
665571001929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571001930	S-adenosylmethionine binding site [chemical binding]; other site
665571001931	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
665571001932	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
665571001933	ATP-grasp domain; Region: ATP-grasp_4; cl17255
665571001934	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
665571001935	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
665571001936	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
665571001937	putative NAD(P) binding site [chemical binding]; other site
665571001938	catalytic Zn binding site [ion binding]; other site
665571001939	structural Zn binding site [ion binding]; other site
665571001940	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
665571001941	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
665571001942	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
665571001943	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
665571001944	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
665571001945	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
665571001946	Walker A/P-loop; other site
665571001947	ATP binding site [chemical binding]; other site
665571001948	Q-loop/lid; other site
665571001949	ABC transporter signature motif; other site
665571001950	Walker B; other site
665571001951	D-loop; other site
665571001952	H-loop/switch region; other site
665571001953	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
665571001954	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
665571001955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571001956	Walker A/P-loop; other site
665571001957	ATP binding site [chemical binding]; other site
665571001958	Q-loop/lid; other site
665571001959	ABC transporter signature motif; other site
665571001960	Walker B; other site
665571001961	D-loop; other site
665571001962	H-loop/switch region; other site
665571001963	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
665571001964	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571001965	putative Zn2+ binding site [ion binding]; other site
665571001966	putative DNA binding site [nucleotide binding]; other site
665571001967	Predicted transcriptional regulators [Transcription]; Region: COG1695
665571001968	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
665571001969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571001970	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571001971	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
665571001972	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
665571001973	Uncharacterized conserved protein [Function unknown]; Region: COG2461
665571001974	Family of unknown function (DUF438); Region: DUF438; pfam04282
665571001975	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
665571001976	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
665571001977	trimer interface [polypeptide binding]; other site
665571001978	putative Zn binding site [ion binding]; other site
665571001979	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
665571001980	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
665571001981	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
665571001982	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
665571001983	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
665571001984	active site
665571001985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
665571001986	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
665571001987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
665571001988	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
665571001989	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
665571001990	NAD(P) binding site [chemical binding]; other site
665571001991	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
665571001992	Transcriptional regulators [Transcription]; Region: FadR; COG2186
665571001993	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
665571001994	DNA-binding site [nucleotide binding]; DNA binding site
665571001995	FCD domain; Region: FCD; pfam07729
665571001996	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
665571001997	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
665571001998	intersubunit interface [polypeptide binding]; other site
665571001999	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
665571002000	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571002001	Walker A/P-loop; other site
665571002002	ATP binding site [chemical binding]; other site
665571002003	Q-loop/lid; other site
665571002004	ABC transporter signature motif; other site
665571002005	Walker B; other site
665571002006	D-loop; other site
665571002007	H-loop/switch region; other site
665571002008	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
665571002009	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
665571002010	ABC-ATPase subunit  interface; other site
665571002011	dimer interface [polypeptide binding]; other site
665571002012	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
665571002013	Malic enzyme, N-terminal domain; Region: malic; pfam00390
665571002014	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
665571002015	putative NAD(P) binding site [chemical binding]; other site
665571002016	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
665571002017	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
665571002018	putative dimer interface [polypeptide binding]; other site
665571002019	[2Fe-2S] cluster binding site [ion binding]; other site
665571002020	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
665571002021	SLBB domain; Region: SLBB; pfam10531
665571002022	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
665571002023	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
665571002024	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
665571002025	catalytic loop [active]
665571002026	iron binding site [ion binding]; other site
665571002027	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
665571002028	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
665571002029	4Fe-4S binding domain; Region: Fer4; pfam00037
665571002030	4Fe-4S binding domain; Region: Fer4; pfam00037
665571002031	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
665571002032	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
665571002033	FeoA domain; Region: FeoA; pfam04023
665571002034	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
665571002035	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
665571002036	G1 box; other site
665571002037	GTP/Mg2+ binding site [chemical binding]; other site
665571002038	G2 box; other site
665571002039	Switch I region; other site
665571002040	G3 box; other site
665571002041	Switch II region; other site
665571002042	G4 box; other site
665571002043	G5 box; other site
665571002044	Nucleoside recognition; Region: Gate; pfam07670
665571002045	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
665571002046	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
665571002047	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
665571002048	non-specific DNA interactions [nucleotide binding]; other site
665571002049	DNA binding site [nucleotide binding]
665571002050	sequence specific DNA binding site [nucleotide binding]; other site
665571002051	putative cAMP binding site [chemical binding]; other site
665571002052	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
665571002053	Ion channel; Region: Ion_trans_2; pfam07885
665571002054	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
665571002055	ligand binding site [chemical binding]; other site
665571002056	flexible hinge region; other site
665571002057	intracellular protease, PfpI family; Region: PfpI; TIGR01382
665571002058	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
665571002059	conserved cys residue [active]
665571002060	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
665571002061	MgtE intracellular N domain; Region: MgtE_N; smart00924
665571002062	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
665571002063	Divalent cation transporter; Region: MgtE; pfam01769
665571002064	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
665571002065	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
665571002066	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
665571002067	active site
665571002068	Glucokinase; Region: Glucokinase; pfam02685
665571002069	glucokinase, proteobacterial type; Region: glk; TIGR00749
665571002070	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
665571002071	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
665571002072	trimer interface [polypeptide binding]; other site
665571002073	putative metal binding site [ion binding]; other site
665571002074	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
665571002075	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
665571002076	DTAP/Switch II; other site
665571002077	Switch I; other site
665571002078	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
665571002079	Carbon starvation protein CstA; Region: CstA; pfam02554
665571002080	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
665571002081	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571002082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002083	dimer interface [polypeptide binding]; other site
665571002084	conserved gate region; other site
665571002085	putative PBP binding loops; other site
665571002086	ABC-ATPase subunit interface; other site
665571002087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002088	dimer interface [polypeptide binding]; other site
665571002089	conserved gate region; other site
665571002090	putative PBP binding loops; other site
665571002091	ABC-ATPase subunit interface; other site
665571002092	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571002093	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571002094	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
665571002095	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
665571002096	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
665571002097	active site
665571002098	FMN binding site [chemical binding]; other site
665571002099	substrate binding site [chemical binding]; other site
665571002100	3Fe-4S cluster binding site [ion binding]; other site
665571002101	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
665571002102	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
665571002103	NodB motif; other site
665571002104	active site
665571002105	catalytic site [active]
665571002106	AzlC protein; Region: AzlC; cl00570
665571002107	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
665571002108	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
665571002109	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
665571002110	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
665571002111	DHH family; Region: DHH; pfam01368
665571002112	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
665571002113	DHHA1 domain; Region: DHHA1; pfam02272
665571002114	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
665571002115	Peptidase family M23; Region: Peptidase_M23; pfam01551
665571002116	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
665571002117	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
665571002118	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
665571002119	active site
665571002120	dimerization interface [polypeptide binding]; other site
665571002121	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
665571002122	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
665571002123	active site
665571002124	metal binding site [ion binding]; metal-binding site
665571002125	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
665571002126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002127	binding surface
665571002128	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571002129	TPR motif; other site
665571002130	TPR repeat; Region: TPR_11; pfam13414
665571002131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002132	binding surface
665571002133	TPR motif; other site
665571002134	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571002135	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002136	binding surface
665571002137	TPR motif; other site
665571002138	TPR repeat; Region: TPR_11; pfam13414
665571002139	Restriction endonuclease; Region: Mrr_cat; pfam04471
665571002140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002141	TPR motif; other site
665571002142	TPR repeat; Region: TPR_11; pfam13414
665571002143	binding surface
665571002144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002145	binding surface
665571002146	TPR motif; other site
665571002147	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571002148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002149	binding surface
665571002150	TPR repeat; Region: TPR_11; pfam13414
665571002151	TPR motif; other site
665571002152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002153	binding surface
665571002154	TPR repeat; Region: TPR_11; pfam13414
665571002155	TPR motif; other site
665571002156	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571002157	TPR repeat; Region: TPR_11; pfam13414
665571002158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002159	binding surface
665571002160	TPR motif; other site
665571002161	TPR repeat; Region: TPR_11; pfam13414
665571002162	TPR repeat; Region: TPR_11; pfam13414
665571002163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002164	binding surface
665571002165	TPR motif; other site
665571002166	TPR repeat; Region: TPR_11; pfam13414
665571002167	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
665571002168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571002169	ATP binding site [chemical binding]; other site
665571002170	Mg2+ binding site [ion binding]; other site
665571002171	G-X-G motif; other site
665571002172	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
665571002173	ATP binding site [chemical binding]; other site
665571002174	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
665571002175	FecR protein; Region: FecR; pfam04773
665571002176	Protein of unknown function (DUF503); Region: DUF503; pfam04456
665571002177	Late competence development protein ComFB; Region: ComFB; pfam10719
665571002178	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
665571002179	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
665571002180	Ligand Binding Site [chemical binding]; other site
665571002181	TIGR00269 family protein; Region: TIGR00269
665571002182	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571002183	Zn2+ binding site [ion binding]; other site
665571002184	Mg2+ binding site [ion binding]; other site
665571002185	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
665571002186	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
665571002187	anti sigma factor interaction site; other site
665571002188	regulatory phosphorylation site [posttranslational modification]; other site
665571002189	PilZ domain; Region: PilZ; pfam07238
665571002190	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
665571002191	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
665571002192	ATP binding site [chemical binding]; other site
665571002193	Mg2+ binding site [ion binding]; other site
665571002194	G-X-G motif; other site
665571002195	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
665571002196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571002197	FeS/SAM binding site; other site
665571002198	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
665571002199	catalytic residues [active]
665571002200	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
665571002201	ATP cone domain; Region: ATP-cone; pfam03477
665571002202	Class III ribonucleotide reductase; Region: RNR_III; cd01675
665571002203	effector binding site; other site
665571002204	active site
665571002205	Zn binding site [ion binding]; other site
665571002206	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
665571002207	ATP cone domain; Region: ATP-cone; pfam03477
665571002208	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
665571002209	ArsC family; Region: ArsC; pfam03960
665571002210	catalytic residue [active]
665571002211	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
665571002212	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
665571002213	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
665571002214	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
665571002215	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
665571002216	wnt family; Region: wnt; pfam00110
665571002217	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
665571002218	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
665571002219	phosphopeptide binding site; other site
665571002220	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
665571002221	IHF dimer interface [polypeptide binding]; other site
665571002222	IHF - DNA interface [nucleotide binding]; other site
665571002223	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
665571002224	active site
665571002225	metal binding site [ion binding]; metal-binding site
665571002226	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
665571002227	Catalytic domain of Protein Kinases; Region: PKc; cd00180
665571002228	active site
665571002229	ATP binding site [chemical binding]; other site
665571002230	substrate binding site [chemical binding]; other site
665571002231	activation loop (A-loop); other site
665571002232	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
665571002233	von Willebrand factor type A domain; Region: VWA_2; pfam13519
665571002234	metal ion-dependent adhesion site (MIDAS); other site
665571002235	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
665571002236	phosphopeptide binding site; other site
665571002237	cobalamin synthase; Reviewed; Region: cobS; PRK00235
665571002238	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
665571002239	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
665571002240	putative dimer interface [polypeptide binding]; other site
665571002241	active site pocket [active]
665571002242	putative cataytic base [active]
665571002243	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
665571002244	homotrimer interface [polypeptide binding]; other site
665571002245	Walker A motif; other site
665571002246	GTP binding site [chemical binding]; other site
665571002247	Walker B motif; other site
665571002248	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
665571002249	Isochorismatase family; Region: Isochorismatase; pfam00857
665571002250	catalytic triad [active]
665571002251	metal binding site [ion binding]; metal-binding site
665571002252	conserved cis-peptide bond; other site
665571002253	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
665571002254	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
665571002255	active site
665571002256	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571002257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002258	dimer interface [polypeptide binding]; other site
665571002259	conserved gate region; other site
665571002260	putative PBP binding loops; other site
665571002261	ABC-ATPase subunit interface; other site
665571002262	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
665571002263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002264	conserved gate region; other site
665571002265	dimer interface [polypeptide binding]; other site
665571002266	putative PBP binding loops; other site
665571002267	ABC-ATPase subunit interface; other site
665571002268	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571002269	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571002270	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
665571002271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571002272	active site
665571002273	phosphorylation site [posttranslational modification]
665571002274	intermolecular recognition site; other site
665571002275	dimerization interface [polypeptide binding]; other site
665571002276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571002277	Walker A motif; other site
665571002278	ATP binding site [chemical binding]; other site
665571002279	Walker B motif; other site
665571002280	arginine finger; other site
665571002281	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
665571002282	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
665571002283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571002284	putative active site [active]
665571002285	heme pocket [chemical binding]; other site
665571002286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571002287	phosphorylation site [posttranslational modification]
665571002288	dimer interface [polypeptide binding]; other site
665571002289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571002290	ATP binding site [chemical binding]; other site
665571002291	Mg2+ binding site [ion binding]; other site
665571002292	G-X-G motif; other site
665571002293	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571002294	YWTD domain; Region: YWTD; cl17223
665571002295	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
665571002296	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
665571002297	bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376
665571002298	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
665571002299	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
665571002300	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
665571002301	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
665571002302	ParB-like nuclease domain; Region: ParB; smart00470
665571002303	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
665571002304	Transglycosylase; Region: Transgly; pfam00912
665571002305	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
665571002306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571002307	S-adenosylmethionine binding site [chemical binding]; other site
665571002308	PEGA domain; Region: PEGA; pfam08308
665571002309	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
665571002310	Peptidase family M23; Region: Peptidase_M23; pfam01551
665571002311	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
665571002312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
665571002313	binding surface
665571002314	TPR motif; other site
665571002315	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571002316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002317	binding surface
665571002318	TPR motif; other site
665571002319	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571002320	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
665571002321	mce related protein; Region: MCE; pfam02470
665571002322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571002323	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571002324	Walker A/P-loop; other site
665571002325	ATP binding site [chemical binding]; other site
665571002326	Q-loop/lid; other site
665571002327	ABC transporter signature motif; other site
665571002328	Walker B; other site
665571002329	D-loop; other site
665571002330	H-loop/switch region; other site
665571002331	Permease; Region: Permease; pfam02405
665571002332	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
665571002333	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
665571002334	active site
665571002335	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
665571002336	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
665571002337	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
665571002338	ligand binding site [chemical binding]; other site
665571002339	flexible hinge region; other site
665571002340	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
665571002341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002342	binding surface
665571002343	TPR motif; other site
665571002344	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
665571002345	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
665571002346	ligand binding site [chemical binding]; other site
665571002347	flexible hinge region; other site
665571002348	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
665571002349	ABC1 family; Region: ABC1; pfam03109
665571002350	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
665571002351	active site
665571002352	ATP binding site [chemical binding]; other site
665571002353	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
665571002354	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
665571002355	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
665571002356	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816
665571002357	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
665571002358	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
665571002359	Rod binding protein; Region: Rod-binding; cl01626
665571002360	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
665571002361	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
665571002362	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571002363	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
665571002364	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571002365	DNA binding residues [nucleotide binding]
665571002366	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
665571002367	NodB motif; other site
665571002368	putative active site [active]
665571002369	putative catalytic site [active]
665571002370	Zn binding site [ion binding]; other site
665571002371	UGMP family protein; Validated; Region: PRK09604
665571002372	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
665571002373	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
665571002374	active site
665571002375	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
665571002376	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
665571002377	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
665571002378	catalytic site [active]
665571002379	subunit interface [polypeptide binding]; other site
665571002380	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
665571002381	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
665571002382	ATP-grasp domain; Region: ATP-grasp_4; cl17255
665571002383	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
665571002384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
665571002385	ATP-grasp domain; Region: ATP-grasp_4; cl17255
665571002386	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
665571002387	IMP binding site; other site
665571002388	dimer interface [polypeptide binding]; other site
665571002389	interdomain contacts; other site
665571002390	partial ornithine binding site; other site
665571002391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
665571002392	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
665571002393	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
665571002394	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
665571002395	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
665571002396	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571002397	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
665571002398	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571002399	Peptidase family M23; Region: Peptidase_M23; pfam01551
665571002400	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
665571002401	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
665571002402	SEC-C motif; Region: SEC-C; pfam02810
665571002403	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
665571002404	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
665571002405	putative substrate binding site [chemical binding]; other site
665571002406	putative ATP binding site [chemical binding]; other site
665571002407	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
665571002408	active site
665571002409	8-oxo-dGMP binding site [chemical binding]; other site
665571002410	nudix motif; other site
665571002411	metal binding site [ion binding]; metal-binding site
665571002412	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
665571002413	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
665571002414	ligand binding site; other site
665571002415	oligomer interface; other site
665571002416	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
665571002417	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
665571002418	dimer interface [polypeptide binding]; other site
665571002419	N-terminal domain interface [polypeptide binding]; other site
665571002420	sulfate 1 binding site; other site
665571002421	glycogen synthase; Provisional; Region: glgA; PRK00654
665571002422	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
665571002423	ADP-binding pocket [chemical binding]; other site
665571002424	homodimer interface [polypeptide binding]; other site
665571002425	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
665571002426	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
665571002427	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
665571002428	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
665571002429	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
665571002430	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
665571002431	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665
665571002432	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
665571002433	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
665571002434	flagellar hook-associated protein FlgL; Validated; Region: PRK06663
665571002435	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
665571002436	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
665571002437	flagellar assembly protein FliW; Provisional; Region: PRK13285
665571002438	carbon storage regulator; Provisional; Region: PRK01712
665571002439	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
665571002440	Glycoprotease family; Region: Peptidase_M22; pfam00814
665571002441	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
665571002442	PilZ domain; Region: PilZ; pfam07238
665571002443	flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664
665571002444	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
665571002445	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
665571002446	FlaG protein; Region: FlaG; pfam03646
665571002447	flagellin; Provisional; Region: PRK12804
665571002448	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
665571002449	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
665571002450	flagellin; Provisional; Region: PRK12804
665571002451	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
665571002452	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
665571002453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002454	binding surface
665571002455	TPR repeat; Region: TPR_11; pfam13414
665571002456	TPR motif; other site
665571002457	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571002458	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571002459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002460	binding surface
665571002461	TPR motif; other site
665571002462	PilZ domain; Region: PilZ; pfam07238
665571002463	Cell division protein ZapA; Region: ZapA; pfam05164
665571002464	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
665571002465	23S rRNA binding site [nucleotide binding]; other site
665571002466	L21 binding site [polypeptide binding]; other site
665571002467	L13 binding site [polypeptide binding]; other site
665571002468	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
665571002469	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
665571002470	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
665571002471	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
665571002472	Methyltransferase domain; Region: Methyltransf_31; pfam13847
665571002473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571002474	S-adenosylmethionine binding site [chemical binding]; other site
665571002475	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
665571002476	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
665571002477	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
665571002478	intersubunit interface [polypeptide binding]; other site
665571002479	active site
665571002480	zinc binding site [ion binding]; other site
665571002481	Na+ binding site [ion binding]; other site
665571002482	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
665571002483	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
665571002484	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
665571002485	active site
665571002486	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571002487	MULE transposase domain; Region: MULE; pfam10551
665571002488	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
665571002489	nudix motif; other site
665571002490	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
665571002491	Part of AAA domain; Region: AAA_19; pfam13245
665571002492	AAA domain; Region: AAA_14; pfam13173
665571002493	Family description; Region: UvrD_C_2; pfam13538
665571002494	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
665571002495	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
665571002496	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
665571002497	transmembrane helices; other site
665571002498	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
665571002499	active site
665571002500	phosphorylation site [posttranslational modification]
665571002501	FOG: CBS domain [General function prediction only]; Region: COG0517
665571002502	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
665571002503	alanyl-tRNA synthetase; Provisional; Region: PRK01584
665571002504	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
665571002505	motif 1; other site
665571002506	active site
665571002507	motif 2; other site
665571002508	motif 3; other site
665571002509	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
665571002510	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
665571002511	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571002512	FeS/SAM binding site; other site
665571002513	TPR repeat; Region: TPR_11; pfam13414
665571002514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002515	binding surface
665571002516	TPR repeat; Region: TPR_11; pfam13414
665571002517	TPR motif; other site
665571002518	TPR repeat; Region: TPR_11; pfam13414
665571002519	TPR repeat; Region: TPR_11; pfam13414
665571002520	TPR repeat; Region: TPR_11; pfam13414
665571002521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002522	binding surface
665571002523	TPR motif; other site
665571002524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002525	TPR motif; other site
665571002526	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571002527	binding surface
665571002528	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
665571002529	putative active site pocket [active]
665571002530	4-fold oligomerization interface [polypeptide binding]; other site
665571002531	metal binding residues [ion binding]; metal-binding site
665571002532	3-fold/trimer interface [polypeptide binding]; other site
665571002533	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
665571002534	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
665571002535	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
665571002536	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
665571002537	motif 1; other site
665571002538	dimer interface [polypeptide binding]; other site
665571002539	active site
665571002540	motif 2; other site
665571002541	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
665571002542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571002543	S-adenosylmethionine binding site [chemical binding]; other site
665571002544	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
665571002545	Y-family of DNA polymerases; Region: PolY; cl12025
665571002546	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
665571002547	generic binding surface II; other site
665571002548	ssDNA binding site; other site
665571002549	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
665571002550	ATP binding site [chemical binding]; other site
665571002551	putative Mg++ binding site [ion binding]; other site
665571002552	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
665571002553	nucleotide binding region [chemical binding]; other site
665571002554	ATP-binding site [chemical binding]; other site
665571002555	YGGT family; Region: YGGT; pfam02325
665571002556	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
665571002557	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
665571002558	active site
665571002559	PHP Thumb interface [polypeptide binding]; other site
665571002560	metal binding site [ion binding]; metal-binding site
665571002561	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
665571002562	generic binding surface I; other site
665571002563	generic binding surface II; other site
665571002564	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
665571002565	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
665571002566	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
665571002567	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
665571002568	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
665571002569	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
665571002570	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
665571002571	inhibitor-cofactor binding pocket; inhibition site
665571002572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571002573	catalytic residue [active]
665571002574	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
665571002575	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
665571002576	NAD(P) binding site [chemical binding]; other site
665571002577	homodimer interface [polypeptide binding]; other site
665571002578	substrate binding site [chemical binding]; other site
665571002579	active site
665571002580	Sporulation related domain; Region: SPOR; pfam05036
665571002581	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
665571002582	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
665571002583	nucleotide binding pocket [chemical binding]; other site
665571002584	K-X-D-G motif; other site
665571002585	catalytic site [active]
665571002586	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
665571002587	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
665571002588	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
665571002589	Dimer interface [polypeptide binding]; other site
665571002590	BRCT sequence motif; other site
665571002591	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
665571002592	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
665571002593	NAD(P) binding site [chemical binding]; other site
665571002594	LDH/MDH dimer interface [polypeptide binding]; other site
665571002595	substrate binding site [chemical binding]; other site
665571002596	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
665571002597	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571002598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002599	dimer interface [polypeptide binding]; other site
665571002600	conserved gate region; other site
665571002601	putative PBP binding loops; other site
665571002602	ABC-ATPase subunit interface; other site
665571002603	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
665571002604	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002605	dimer interface [polypeptide binding]; other site
665571002606	ABC-ATPase subunit interface; other site
665571002607	putative PBP binding loops; other site
665571002608	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571002609	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571002610	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
665571002611	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571002612	putative DNA binding site [nucleotide binding]; other site
665571002613	putative Zn2+ binding site [ion binding]; other site
665571002614	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
665571002615	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
665571002616	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
665571002617	E3 interaction surface; other site
665571002618	lipoyl attachment site [posttranslational modification]; other site
665571002619	e3 binding domain; Region: E3_binding; pfam02817
665571002620	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
665571002621	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
665571002622	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
665571002623	tetramer interface [polypeptide binding]; other site
665571002624	TPP-binding site [chemical binding]; other site
665571002625	heterodimer interface [polypeptide binding]; other site
665571002626	phosphorylation loop region [posttranslational modification]
665571002627	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
665571002628	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
665571002629	PYR/PP interface [polypeptide binding]; other site
665571002630	dimer interface [polypeptide binding]; other site
665571002631	TPP binding site [chemical binding]; other site
665571002632	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
665571002633	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
665571002634	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571002635	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
665571002636	NAD(P) binding site [chemical binding]; other site
665571002637	active site
665571002638	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
665571002639	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
665571002640	nucleotide binding site [chemical binding]; other site
665571002641	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
665571002642	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
665571002643	putative NAD(P) binding site [chemical binding]; other site
665571002644	catalytic Zn binding site [ion binding]; other site
665571002645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
665571002646	dimerization interface [polypeptide binding]; other site
665571002647	Histidine kinase; Region: His_kinase; pfam06580
665571002648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571002649	ATP binding site [chemical binding]; other site
665571002650	Mg2+ binding site [ion binding]; other site
665571002651	G-X-G motif; other site
665571002652	Response regulator receiver domain; Region: Response_reg; pfam00072
665571002653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571002654	active site
665571002655	phosphorylation site [posttranslational modification]
665571002656	intermolecular recognition site; other site
665571002657	dimerization interface [polypeptide binding]; other site
665571002658	Helix-turn-helix domain; Region: HTH_18; pfam12833
665571002659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571002660	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
665571002661	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
665571002662	ligand binding site [chemical binding]; other site
665571002663	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
665571002664	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
665571002665	Walker A/P-loop; other site
665571002666	ATP binding site [chemical binding]; other site
665571002667	Q-loop/lid; other site
665571002668	ABC transporter signature motif; other site
665571002669	Walker B; other site
665571002670	D-loop; other site
665571002671	H-loop/switch region; other site
665571002672	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
665571002673	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571002674	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
665571002675	TM-ABC transporter signature motif; other site
665571002676	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571002677	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
665571002678	TM-ABC transporter signature motif; other site
665571002679	Domain of unknown function (DUF718); Region: DUF718; pfam05336
665571002680	Uncharacterized conserved protein [Function unknown]; Region: COG3347
665571002681	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
665571002682	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
665571002683	L-rhamnose isomerase; Provisional; Region: PRK01076
665571002684	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571002685	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571002686	dimer interface [polypeptide binding]; other site
665571002687	putative CheW interface [polypeptide binding]; other site
665571002688	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
665571002689	Histidine kinase; Region: His_kinase; pfam06580
665571002690	Response regulator receiver domain; Region: Response_reg; pfam00072
665571002691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571002692	active site
665571002693	phosphorylation site [posttranslational modification]
665571002694	intermolecular recognition site; other site
665571002695	dimerization interface [polypeptide binding]; other site
665571002696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571002697	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
665571002698	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571002699	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571002700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571002701	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
665571002702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002703	dimer interface [polypeptide binding]; other site
665571002704	conserved gate region; other site
665571002705	putative PBP binding loops; other site
665571002706	ABC-ATPase subunit interface; other site
665571002707	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571002708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002709	dimer interface [polypeptide binding]; other site
665571002710	conserved gate region; other site
665571002711	putative PBP binding loops; other site
665571002712	ABC-ATPase subunit interface; other site
665571002713	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
665571002714	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
665571002715	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571002716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002717	dimer interface [polypeptide binding]; other site
665571002718	conserved gate region; other site
665571002719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
665571002720	ABC-ATPase subunit interface; other site
665571002721	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571002722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571002723	dimer interface [polypeptide binding]; other site
665571002724	conserved gate region; other site
665571002725	ABC-ATPase subunit interface; other site
665571002726	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571002727	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571002728	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
665571002729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571002730	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
665571002731	active site
665571002732	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
665571002733	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
665571002734	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
665571002735	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
665571002736	acyl-activating enzyme (AAE) consensus motif; other site
665571002737	putative AMP binding site [chemical binding]; other site
665571002738	putative active site [active]
665571002739	putative CoA binding site [chemical binding]; other site
665571002740	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
665571002741	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
665571002742	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
665571002743	carboxyltransferase (CT) interaction site; other site
665571002744	biotinylation site [posttranslational modification]; other site
665571002745	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
665571002746	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
665571002747	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
665571002748	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
665571002749	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
665571002750	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
665571002751	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
665571002752	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
665571002753	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
665571002754	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
665571002755	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
665571002756	catalytic residues [active]
665571002757	CAAX protease self-immunity; Region: Abi; pfam02517
665571002758	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
665571002759	PilZ domain; Region: PilZ; pfam07238
665571002760	Competence protein; Region: Competence; pfam03772
665571002761	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
665571002762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571002763	S-adenosylmethionine binding site [chemical binding]; other site
665571002764	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
665571002765	dihydrodipicolinate synthase; Region: dapA; TIGR00674
665571002766	dimer interface [polypeptide binding]; other site
665571002767	active site
665571002768	catalytic residue [active]
665571002769	dihydrodipicolinate reductase; Provisional; Region: PRK00048
665571002770	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
665571002771	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
665571002772	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
665571002773	arogenate dehydrogenase; Region: PLN02256
665571002774	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
665571002775	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
665571002776	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
665571002777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002778	TPR motif; other site
665571002779	binding surface
665571002780	TPR repeat; Region: TPR_11; pfam13414
665571002781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002782	binding surface
665571002783	TPR motif; other site
665571002784	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
665571002785	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
665571002786	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571002787	FeS/SAM binding site; other site
665571002788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002789	binding surface
665571002790	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571002791	TPR motif; other site
665571002792	TPR repeat; Region: TPR_11; pfam13414
665571002793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
665571002794	TPR repeat; Region: TPR_11; pfam13414
665571002795	binding surface
665571002796	TPR motif; other site
665571002797	adenylate kinase; Reviewed; Region: adk; PRK00279
665571002798	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
665571002799	AMP-binding site [chemical binding]; other site
665571002800	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
665571002801	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
665571002802	putative CheA interaction surface; other site
665571002803	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
665571002804	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
665571002805	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571002806	catalytic residue [active]
665571002807	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
665571002808	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
665571002809	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
665571002810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571002811	Walker A/P-loop; other site
665571002812	ATP binding site [chemical binding]; other site
665571002813	Q-loop/lid; other site
665571002814	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
665571002815	ABC transporter signature motif; other site
665571002816	Walker B; other site
665571002817	D-loop; other site
665571002818	H-loop/switch region; other site
665571002819	Methyltransferase domain; Region: Methyltransf_23; pfam13489
665571002820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571002821	S-adenosylmethionine binding site [chemical binding]; other site
665571002822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
665571002823	Uncharacterized conserved protein [Function unknown]; Region: COG1543
665571002824	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
665571002825	active site
665571002826	substrate binding site [chemical binding]; other site
665571002827	catalytic site [active]
665571002828	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
665571002829	cell division protein MraZ; Reviewed; Region: PRK00326
665571002830	MraZ protein; Region: MraZ; pfam02381
665571002831	MraZ protein; Region: MraZ; pfam02381
665571002832	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
665571002833	MraW methylase family; Region: Methyltransf_5; cl17771
665571002834	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
665571002835	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
665571002836	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
665571002837	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
665571002838	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
665571002839	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
665571002840	Mg++ binding site [ion binding]; other site
665571002841	putative catalytic motif [active]
665571002842	putative substrate binding site [chemical binding]; other site
665571002843	cell division protein FtsW; Region: ftsW; TIGR02614
665571002844	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
665571002845	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
665571002846	cell division protein FtsA; Region: ftsA; TIGR01174
665571002847	Cell division protein FtsA; Region: FtsA; smart00842
665571002848	Cell division protein FtsA; Region: FtsA; pfam14450
665571002849	cell division protein FtsZ; Validated; Region: PRK09330
665571002850	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
665571002851	nucleotide binding site [chemical binding]; other site
665571002852	SulA interaction site; other site
665571002853	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
665571002854	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
665571002855	active site
665571002856	DNA binding site [nucleotide binding]
665571002857	Int/Topo IB signature motif; other site
665571002858	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002859	TPR repeat; Region: TPR_11; pfam13414
665571002860	binding surface
665571002861	TPR motif; other site
665571002862	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571002863	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571002864	binding surface
665571002865	TPR motif; other site
665571002866	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
665571002867	DNA protecting protein DprA; Region: dprA; TIGR00732
665571002868	DNA topoisomerase I; Validated; Region: PRK05582
665571002869	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
665571002870	active site
665571002871	interdomain interaction site; other site
665571002872	putative metal-binding site [ion binding]; other site
665571002873	nucleotide binding site [chemical binding]; other site
665571002874	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
665571002875	domain I; other site
665571002876	DNA binding groove [nucleotide binding]
665571002877	phosphate binding site [ion binding]; other site
665571002878	domain II; other site
665571002879	domain III; other site
665571002880	nucleotide binding site [chemical binding]; other site
665571002881	catalytic site [active]
665571002882	domain IV; other site
665571002883	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
665571002884	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
665571002885	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
665571002886	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
665571002887	active site
665571002888	DNA binding site [nucleotide binding]
665571002889	Int/Topo IB signature motif; other site
665571002890	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
665571002891	active site
665571002892	HslU subunit interaction site [polypeptide binding]; other site
665571002893	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
665571002894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571002895	Walker A motif; other site
665571002896	ATP binding site [chemical binding]; other site
665571002897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571002898	Walker B motif; other site
665571002899	arginine finger; other site
665571002900	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
665571002901	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624
665571002902	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
665571002903	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
665571002904	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
665571002905	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
665571002906	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
665571002907	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
665571002908	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
665571002909	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
665571002910	FliG C-terminal domain; Region: FliG_C; pfam01706
665571002911	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
665571002912	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
665571002913	Flagellar assembly protein FliH; Region: FliH; pfam02108
665571002914	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
665571002915	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
665571002916	Walker A motif/ATP binding site; other site
665571002917	Walker B motif; other site
665571002918	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
665571002919	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
665571002920	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
665571002921	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
665571002922	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
665571002923	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
665571002924	Flagellar protein (FlbD); Region: FlbD; pfam06289
665571002925	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
665571002926	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
665571002927	flagellar motor protein MotB; Validated; Region: motB; PRK06667
665571002928	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
665571002929	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
665571002930	ligand binding site [chemical binding]; other site
665571002931	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
665571002932	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
665571002933	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
665571002934	flagellar motor switch protein; Validated; Region: PRK08119
665571002935	flagellar motor switch protein FliN; Region: fliN; TIGR02480
665571002936	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
665571002937	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
665571002938	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
665571002939	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
665571002940	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
665571002941	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
665571002942	FHIPEP family; Region: FHIPEP; pfam00771
665571002943	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
665571002944	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723
665571002945	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
665571002946	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
665571002947	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
665571002948	P-loop; other site
665571002949	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
665571002950	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571002951	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
665571002952	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571002953	DNA binding residues [nucleotide binding]
665571002954	Protein of unknown function (DUF342); Region: DUF342; pfam03961
665571002955	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
665571002956	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
665571002957	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
665571002958	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
665571002959	AAA domain; Region: AAA_26; pfam13500
665571002960	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
665571002961	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
665571002962	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
665571002963	active site
665571002964	catalytic residues [active]
665571002965	metal binding site [ion binding]; metal-binding site
665571002966	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
665571002967	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
665571002968	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
665571002969	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
665571002970	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
665571002971	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
665571002972	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
665571002973	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
665571002974	Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687
665571002975	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
665571002976	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
665571002977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
665571002978	dimerization interface [polypeptide binding]; other site
665571002979	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
665571002980	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
665571002981	Uncharacterized conserved protein [Function unknown]; Region: COG1430
665571002982	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
665571002983	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
665571002984	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
665571002985	generic binding surface II; other site
665571002986	generic binding surface I; other site
665571002987	Radical SAM superfamily; Region: Radical_SAM; pfam04055
665571002988	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571002989	FeS/SAM binding site; other site
665571002990	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
665571002991	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
665571002992	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
665571002993	active site
665571002994	Methyltransferase domain; Region: Methyltransf_23; pfam13489
665571002995	Methyltransferase domain; Region: Methyltransf_12; pfam08242
665571002996	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027
665571002997	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
665571002998	NAD binding site [chemical binding]; other site
665571002999	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
665571003000	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
665571003001	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
665571003002	active site
665571003003	metal binding site [ion binding]; metal-binding site
665571003004	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
665571003005	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
665571003006	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
665571003007	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
665571003008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571003009	homodimer interface [polypeptide binding]; other site
665571003010	catalytic residue [active]
665571003011	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
665571003012	Uncharacterized conserved protein [Function unknown]; Region: COG2454
665571003013	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
665571003014	PhoH-like protein; Region: PhoH; pfam02562
665571003015	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
665571003016	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
665571003017	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571003018	Zn2+ binding site [ion binding]; other site
665571003019	Mg2+ binding site [ion binding]; other site
665571003020	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
665571003021	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
665571003022	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
665571003023	Transporter associated domain; Region: CorC_HlyC; smart01091
665571003024	TPR repeat; Region: TPR_11; pfam13414
665571003025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003026	binding surface
665571003027	TPR motif; other site
665571003028	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003030	TPR motif; other site
665571003031	binding surface
665571003032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003033	binding surface
665571003034	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003035	TPR motif; other site
665571003036	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
665571003037	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
665571003038	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
665571003039	Phosphoglycerate kinase; Region: PGK; pfam00162
665571003040	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
665571003041	substrate binding site [chemical binding]; other site
665571003042	hinge regions; other site
665571003043	ADP binding site [chemical binding]; other site
665571003044	catalytic site [active]
665571003045	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
665571003046	triosephosphate isomerase; Provisional; Region: PRK14565
665571003047	substrate binding site [chemical binding]; other site
665571003048	dimer interface [polypeptide binding]; other site
665571003049	catalytic triad [active]
665571003050	Preprotein translocase SecG subunit; Region: SecG; pfam03840
665571003051	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
665571003052	HSP70 interaction site [polypeptide binding]; other site
665571003053	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
665571003054	SurA N-terminal domain; Region: SurA_N; pfam09312
665571003055	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
665571003056	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
665571003057	putative RNA binding site [nucleotide binding]; other site
665571003058	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
665571003059	active site
665571003060	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
665571003061	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
665571003062	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
665571003063	protein binding site [polypeptide binding]; other site
665571003064	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
665571003065	protein binding site [polypeptide binding]; other site
665571003066	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
665571003067	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
665571003068	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
665571003069	homodimer interface [polypeptide binding]; other site
665571003070	NADP binding site [chemical binding]; other site
665571003071	substrate binding site [chemical binding]; other site
665571003072	putative GTP cyclohydrolase; Provisional; Region: PRK13674
665571003073	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
665571003074	purine monophosphate binding site [chemical binding]; other site
665571003075	dimer interface [polypeptide binding]; other site
665571003076	putative catalytic residues [active]
665571003077	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
665571003078	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335
665571003079	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
665571003080	TRAM domain; Region: TRAM; cl01282
665571003081	Sporulation related domain; Region: SPOR; pfam05036
665571003082	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
665571003083	Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595
665571003084	tetramer interface [polypeptide binding]; other site
665571003085	active site
665571003086	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
665571003087	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
665571003088	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
665571003089	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
665571003090	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
665571003091	active site
665571003092	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
665571003093	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
665571003094	GDP-binding site [chemical binding]; other site
665571003095	ACT binding site; other site
665571003096	IMP binding site; other site
665571003097	GMP synthase; Reviewed; Region: guaA; PRK00074
665571003098	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
665571003099	AMP/PPi binding site [chemical binding]; other site
665571003100	candidate oxyanion hole; other site
665571003101	catalytic triad [active]
665571003102	potential glutamine specificity residues [chemical binding]; other site
665571003103	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
665571003104	ATP Binding subdomain [chemical binding]; other site
665571003105	Ligand Binding sites [chemical binding]; other site
665571003106	Dimerization subdomain; other site
665571003107	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
665571003108	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571003109	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571003110	DNA binding residues [nucleotide binding]
665571003111	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
665571003112	HlyD family secretion protein; Region: HlyD_2; pfam12700
665571003113	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
665571003114	HlyD family secretion protein; Region: HlyD_3; pfam13437
665571003115	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571003116	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
665571003117	Walker A/P-loop; other site
665571003118	ATP binding site [chemical binding]; other site
665571003119	Q-loop/lid; other site
665571003120	ABC transporter signature motif; other site
665571003121	Walker B; other site
665571003122	D-loop; other site
665571003123	H-loop/switch region; other site
665571003124	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571003125	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
665571003126	FtsX-like permease family; Region: FtsX; pfam02687
665571003127	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571003128	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
665571003129	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571003130	Peptidase family M23; Region: Peptidase_M23; pfam01551
665571003131	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
665571003132	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
665571003133	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571003134	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
665571003135	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571003136	DNA binding residues [nucleotide binding]
665571003137	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
665571003138	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
665571003139	putative active site [active]
665571003140	nucleotide binding site [chemical binding]; other site
665571003141	nudix motif; other site
665571003142	putative metal binding site [ion binding]; other site
665571003143	Protein of unknown function (DUF763); Region: DUF763; pfam05559
665571003144	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571003145	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571003146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571003147	dimer interface [polypeptide binding]; other site
665571003148	conserved gate region; other site
665571003149	putative PBP binding loops; other site
665571003150	ABC-ATPase subunit interface; other site
665571003151	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571003152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571003153	dimer interface [polypeptide binding]; other site
665571003154	conserved gate region; other site
665571003155	putative PBP binding loops; other site
665571003156	ABC-ATPase subunit interface; other site
665571003157	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
665571003158	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
665571003159	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
665571003160	trimer interface [polypeptide binding]; other site
665571003161	active site
665571003162	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
665571003163	catalytic site [active]
665571003164	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571003165	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571003166	DNA binding site [nucleotide binding]
665571003167	domain linker motif; other site
665571003168	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
665571003169	putative dimerization interface [polypeptide binding]; other site
665571003170	putative ligand binding site [chemical binding]; other site
665571003171	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
665571003172	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
665571003173	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
665571003174	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
665571003175	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
665571003176	active site
665571003177	HIGH motif; other site
665571003178	KMSK motif region; other site
665571003179	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
665571003180	tRNA binding surface [nucleotide binding]; other site
665571003181	anticodon binding site; other site
665571003182	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
665571003183	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
665571003184	active site
665571003185	dimer interface [polypeptide binding]; other site
665571003186	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
665571003187	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
665571003188	active site
665571003189	FMN binding site [chemical binding]; other site
665571003190	substrate binding site [chemical binding]; other site
665571003191	3Fe-4S cluster binding site [ion binding]; other site
665571003192	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
665571003193	domain interface; other site
665571003194	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
665571003195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
665571003196	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
665571003197	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
665571003198	Protein of unknown function (DUF464); Region: DUF464; cl01080
665571003199	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
665571003200	GTPase CgtA; Reviewed; Region: obgE; PRK12299
665571003201	GTP1/OBG; Region: GTP1_OBG; pfam01018
665571003202	Obg GTPase; Region: Obg; cd01898
665571003203	G1 box; other site
665571003204	GTP/Mg2+ binding site [chemical binding]; other site
665571003205	Switch I region; other site
665571003206	G2 box; other site
665571003207	G3 box; other site
665571003208	Switch II region; other site
665571003209	G4 box; other site
665571003210	G5 box; other site
665571003211	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
665571003212	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
665571003213	active site
665571003214	(T/H)XGH motif; other site
665571003215	Transcriptional regulator [Transcription]; Region: LytR; COG1316
665571003216	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
665571003217	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
665571003218	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
665571003219	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
665571003220	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
665571003221	dimerization interface [polypeptide binding]; other site
665571003222	active site
665571003223	L-aspartate oxidase; Region: nadB; TIGR00551
665571003224	L-aspartate oxidase; Provisional; Region: PRK06175
665571003225	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
665571003226	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
665571003227	regulatory protein SpoVG; Reviewed; Region: PRK13259
665571003228	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
665571003229	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
665571003230	5S rRNA interface [nucleotide binding]; other site
665571003231	CTC domain interface [polypeptide binding]; other site
665571003232	L16 interface [polypeptide binding]; other site
665571003233	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
665571003234	putative active site [active]
665571003235	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
665571003236	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
665571003237	Ligand Binding Site [chemical binding]; other site
665571003238	TilS substrate C-terminal domain; Region: TilS_C; cl17443
665571003239	FtsH Extracellular; Region: FtsH_ext; pfam06480
665571003240	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
665571003241	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003242	Walker A motif; other site
665571003243	ATP binding site [chemical binding]; other site
665571003244	Walker B motif; other site
665571003245	arginine finger; other site
665571003246	Peptidase family M41; Region: Peptidase_M41; pfam01434
665571003247	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
665571003248	PDZ domain; Region: PDZ_2; pfam13180
665571003249	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
665571003250	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
665571003251	RNA/DNA hybrid binding site [nucleotide binding]; other site
665571003252	active site
665571003253	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
665571003254	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
665571003255	Walker A/P-loop; other site
665571003256	ATP binding site [chemical binding]; other site
665571003257	Q-loop/lid; other site
665571003258	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
665571003259	ABC transporter signature motif; other site
665571003260	Walker B; other site
665571003261	D-loop; other site
665571003262	H-loop/switch region; other site
665571003263	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
665571003264	signal recognition particle protein; Provisional; Region: PRK10867
665571003265	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
665571003266	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
665571003267	P loop; other site
665571003268	GTP binding site [chemical binding]; other site
665571003269	Signal peptide binding domain; Region: SRP_SPB; pfam02978
665571003270	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
665571003271	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
665571003272	hypothetical protein; Provisional; Region: PRK00468
665571003273	G-X-X-G motif; other site
665571003274	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
665571003275	RimM N-terminal domain; Region: RimM; pfam01782
665571003276	PRC-barrel domain; Region: PRC; pfam05239
665571003277	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
665571003278	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
665571003279	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
665571003280	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
665571003281	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571003282	Zn2+ binding site [ion binding]; other site
665571003283	Mg2+ binding site [ion binding]; other site
665571003284	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
665571003285	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
665571003286	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
665571003287	active site
665571003288	(T/H)XGH motif; other site
665571003289	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
665571003290	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
665571003291	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
665571003292	acyl carrier protein; Provisional; Region: acpP; PRK00982
665571003293	ribonuclease III; Reviewed; Region: rnc; PRK00102
665571003294	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
665571003295	dimerization interface [polypeptide binding]; other site
665571003296	active site
665571003297	metal binding site [ion binding]; metal-binding site
665571003298	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
665571003299	dsRNA binding site [nucleotide binding]; other site
665571003300	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
665571003301	active site
665571003302	NTP binding site [chemical binding]; other site
665571003303	metal binding triad [ion binding]; metal-binding site
665571003304	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
665571003305	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571003306	Zn2+ binding site [ion binding]; other site
665571003307	Mg2+ binding site [ion binding]; other site
665571003308	flagellin; Provisional; Region: PRK12804
665571003309	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
665571003310	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
665571003311	Thiamine pyrophosphokinase; Region: TPK; cd07995
665571003312	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
665571003313	active site
665571003314	dimerization interface [polypeptide binding]; other site
665571003315	thiamine binding site [chemical binding]; other site
665571003316	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
665571003317	nucleotide binding site/active site [active]
665571003318	HIT family signature motif; other site
665571003319	catalytic residue [active]
665571003320	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
665571003321	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
665571003322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571003323	motif II; other site
665571003324	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
665571003325	active site
665571003326	Flagellin N-methylase; Region: FliB; cl00497
665571003327	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
665571003328	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571003329	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571003330	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
665571003331	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
665571003332	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571003333	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571003334	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
665571003335	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
665571003336	ligand binding site [chemical binding]; other site
665571003337	YceG-like family; Region: YceG; pfam02618
665571003338	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
665571003339	dimerization interface [polypeptide binding]; other site
665571003340	DNA primase; Validated; Region: dnaG; PRK05667
665571003341	CHC2 zinc finger; Region: zf-CHC2; cl17510
665571003342	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
665571003343	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
665571003344	active site
665571003345	metal binding site [ion binding]; metal-binding site
665571003346	interdomain interaction site; other site
665571003347	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
665571003348	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
665571003349	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
665571003350	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571003351	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
665571003352	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571003353	DNA binding residues [nucleotide binding]
665571003354	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
665571003355	Lactococcus lactis bacteriophage major capsid protein; Region: L_lactis_ph-MCP; pfam06673
665571003356	Putative zinc ribbon domain; Region: DUF164; pfam02591
665571003357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
665571003358	binding surface
665571003359	TPR motif; other site
665571003360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003361	binding surface
665571003362	TPR repeat; Region: TPR_11; pfam13414
665571003363	TPR motif; other site
665571003364	rod shape-determining protein MreB; Provisional; Region: PRK13927
665571003365	MreB and similar proteins; Region: MreB_like; cd10225
665571003366	nucleotide binding site [chemical binding]; other site
665571003367	Mg binding site [ion binding]; other site
665571003368	putative protofilament interaction site [polypeptide binding]; other site
665571003369	RodZ interaction site [polypeptide binding]; other site
665571003370	rod shape-determining protein MreC; Provisional; Region: PRK13922
665571003371	rod shape-determining protein MreC; Region: MreC; pfam04085
665571003372	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
665571003373	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
665571003374	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
665571003375	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
665571003376	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
665571003377	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
665571003378	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
665571003379	B12 binding site [chemical binding]; other site
665571003380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571003381	FeS/SAM binding site; other site
665571003382	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
665571003383	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
665571003384	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
665571003385	homodimer interface [polypeptide binding]; other site
665571003386	metal binding site [ion binding]; metal-binding site
665571003387	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
665571003388	homodimer interface [polypeptide binding]; other site
665571003389	active site
665571003390	putative chemical substrate binding site [chemical binding]; other site
665571003391	metal binding site [ion binding]; metal-binding site
665571003392	CHASE2 domain; Region: CHASE2; pfam05226
665571003393	CHASE2 domain; Region: CHASE2; pfam05226
665571003394	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
665571003395	cyclase homology domain; Region: CHD; cd07302
665571003396	nucleotidyl binding site; other site
665571003397	metal binding site [ion binding]; metal-binding site
665571003398	dimer interface [polypeptide binding]; other site
665571003399	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
665571003400	Tetratricopeptide repeat; Region: TPR_6; pfam13174
665571003401	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
665571003402	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
665571003403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003404	Walker A motif; other site
665571003405	ATP binding site [chemical binding]; other site
665571003406	Walker B motif; other site
665571003407	arginine finger; other site
665571003408	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
665571003409	bifunctional cytidylate kinase/ribosomal protein S1; Provisional; Region: PRK12269
665571003410	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
665571003411	CMP-binding site; other site
665571003412	The sites determining sugar specificity; other site
665571003413	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
665571003414	RNA binding site [nucleotide binding]; other site
665571003415	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
665571003416	RNA binding site [nucleotide binding]; other site
665571003417	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
665571003418	RNA binding site [nucleotide binding]; other site
665571003419	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
665571003420	RNA binding site [nucleotide binding]; other site
665571003421	S1 RNA binding domain; Region: S1; pfam00575
665571003422	RNA binding site [nucleotide binding]; other site
665571003423	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
665571003424	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
665571003425	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
665571003426	RNA binding surface [nucleotide binding]; other site
665571003427	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
665571003428	active site
665571003429	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
665571003430	ScpA/B protein; Region: ScpA_ScpB; cl00598
665571003431	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
665571003432	catalytic center binding site [active]
665571003433	ATP binding site [chemical binding]; other site
665571003434	recombinase A; Provisional; Region: recA; PRK09354
665571003435	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
665571003436	hexamer interface [polypeptide binding]; other site
665571003437	Walker A motif; other site
665571003438	ATP binding site [chemical binding]; other site
665571003439	Walker B motif; other site
665571003440	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
665571003441	dimerization interface [polypeptide binding]; other site
665571003442	putative tRNAtyr binding site [nucleotide binding]; other site
665571003443	putative active site [active]
665571003444	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003446	TPR motif; other site
665571003447	binding surface
665571003448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003449	binding surface
665571003450	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003451	TPR motif; other site
665571003452	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003453	capsid protein IX,hexon associated protein IX; Provisional; Region: IX; PHA03385
665571003454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
665571003455	TPR motif; other site
665571003456	binding surface
665571003457	transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720
665571003458	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
665571003459	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
665571003460	HEAT repeats; Region: HEAT_2; pfam13646
665571003461	HEAT repeats; Region: HEAT_2; pfam13646
665571003462	MviN-like protein; Region: MVIN; pfam03023
665571003463	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
665571003464	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
665571003465	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
665571003466	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
665571003467	Predicted permeases [General function prediction only]; Region: COG0795
665571003468	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
665571003469	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
665571003470	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
665571003471	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
665571003472	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
665571003473	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
665571003474	RNase E interface [polypeptide binding]; other site
665571003475	trimer interface [polypeptide binding]; other site
665571003476	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
665571003477	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
665571003478	RNase E interface [polypeptide binding]; other site
665571003479	trimer interface [polypeptide binding]; other site
665571003480	active site
665571003481	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
665571003482	putative nucleic acid binding region [nucleotide binding]; other site
665571003483	G-X-X-G motif; other site
665571003484	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
665571003485	RNA binding site [nucleotide binding]; other site
665571003486	domain interface; other site
665571003487	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
665571003488	16S/18S rRNA binding site [nucleotide binding]; other site
665571003489	S13e-L30e interaction site [polypeptide binding]; other site
665571003490	25S rRNA binding site [nucleotide binding]; other site
665571003491	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
665571003492	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
665571003493	active site
665571003494	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
665571003495	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
665571003496	RNA binding site [nucleotide binding]; other site
665571003497	active site
665571003498	Ribosome-binding factor A; Region: RBFA; pfam02033
665571003499	translation initiation factor IF-2; Region: IF-2; TIGR00487
665571003500	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
665571003501	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
665571003502	G1 box; other site
665571003503	putative GEF interaction site [polypeptide binding]; other site
665571003504	GTP/Mg2+ binding site [chemical binding]; other site
665571003505	Switch I region; other site
665571003506	G2 box; other site
665571003507	G3 box; other site
665571003508	Switch II region; other site
665571003509	G4 box; other site
665571003510	G5 box; other site
665571003511	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
665571003512	Translation-initiation factor 2; Region: IF-2; pfam11987
665571003513	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
665571003514	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
665571003515	NusA N-terminal domain; Region: NusA_N; pfam08529
665571003516	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
665571003517	RNA binding site [nucleotide binding]; other site
665571003518	homodimer interface [polypeptide binding]; other site
665571003519	NusA-like KH domain; Region: KH_5; pfam13184
665571003520	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
665571003521	G-X-X-G motif; other site
665571003522	Double zinc ribbon; Region: DZR; pfam12773
665571003523	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
665571003524	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
665571003525	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
665571003526	putative oligomer interface [polypeptide binding]; other site
665571003527	putative RNA binding site [nucleotide binding]; other site
665571003528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571003529	Histidine kinase; Region: HisKA_2; pfam07568
665571003530	comF family protein; Region: comF; TIGR00201
665571003531	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
665571003532	active site
665571003533	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
665571003534	MutS domain I; Region: MutS_I; pfam01624
665571003535	MutS domain II; Region: MutS_II; pfam05188
665571003536	MutS domain III; Region: MutS_III; pfam05192
665571003537	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
665571003538	Walker A/P-loop; other site
665571003539	ATP binding site [chemical binding]; other site
665571003540	Q-loop/lid; other site
665571003541	ABC transporter signature motif; other site
665571003542	Walker B; other site
665571003543	D-loop; other site
665571003544	H-loop/switch region; other site
665571003545	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
665571003546	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
665571003547	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
665571003548	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
665571003549	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
665571003550	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
665571003551	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
665571003552	Surface antigen; Region: Bac_surface_Ag; pfam01103
665571003553	Surface antigen; Region: Bac_surface_Ag; pfam01103
665571003554	Family of unknown function (DUF490); Region: DUF490; pfam04357
665571003555	Family of unknown function (DUF490); Region: DUF490; pfam04357
665571003556	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
665571003557	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
665571003558	TMP-binding site; other site
665571003559	ATP-binding site [chemical binding]; other site
665571003560	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
665571003561	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
665571003562	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
665571003563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003564	Walker A motif; other site
665571003565	ATP binding site [chemical binding]; other site
665571003566	Walker B motif; other site
665571003567	arginine finger; other site
665571003568	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
665571003569	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
665571003570	RuvA N terminal domain; Region: RuvA_N; pfam01330
665571003571	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
665571003572	active site
665571003573	putative DNA-binding cleft [nucleotide binding]; other site
665571003574	dimer interface [polypeptide binding]; other site
665571003575	hypothetical protein; Validated; Region: PRK00110
665571003576	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
665571003577	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
665571003578	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
665571003579	Catalytic site [active]
665571003580	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
665571003581	PEGA domain; Region: PEGA; pfam08308
665571003582	Uncharacterized conserved protein [Function unknown]; Region: COG1262
665571003583	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
665571003584	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
665571003585	SmpB-tmRNA interface; other site
665571003586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003587	binding surface
665571003588	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003589	TPR motif; other site
665571003590	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003591	TPR repeat; Region: TPR_11; pfam13414
665571003592	binding surface
665571003593	TPR motif; other site
665571003594	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
665571003595	Predicted permease; Region: DUF318; cl17795
665571003596	Predicted permease; Region: DUF318; cl17795
665571003597	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571003598	dimerization interface [polypeptide binding]; other site
665571003599	putative DNA binding site [nucleotide binding]; other site
665571003600	putative Zn2+ binding site [ion binding]; other site
665571003601	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
665571003602	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
665571003603	ligand binding site [chemical binding]; other site
665571003604	Protein of unknown function (DUF429); Region: DUF429; cl12046
665571003605	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
665571003606	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
665571003607	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
665571003608	metal binding triad [ion binding]; metal-binding site
665571003609	SurA N-terminal domain; Region: SurA_N_3; cl07813
665571003610	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
665571003611	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
665571003612	GTP-binding protein LepA; Provisional; Region: PRK05433
665571003613	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
665571003614	G1 box; other site
665571003615	putative GEF interaction site [polypeptide binding]; other site
665571003616	GTP/Mg2+ binding site [chemical binding]; other site
665571003617	Switch I region; other site
665571003618	G2 box; other site
665571003619	G3 box; other site
665571003620	Switch II region; other site
665571003621	G4 box; other site
665571003622	G5 box; other site
665571003623	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
665571003624	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
665571003625	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
665571003626	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571003627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571003628	active site
665571003629	phosphorylation site [posttranslational modification]
665571003630	intermolecular recognition site; other site
665571003631	dimerization interface [polypeptide binding]; other site
665571003632	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
665571003633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571003634	putative active site [active]
665571003635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571003636	dimer interface [polypeptide binding]; other site
665571003637	phosphorylation site [posttranslational modification]
665571003638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571003639	ATP binding site [chemical binding]; other site
665571003640	Mg2+ binding site [ion binding]; other site
665571003641	G-X-G motif; other site
665571003642	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571003643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571003644	active site
665571003645	phosphorylation site [posttranslational modification]
665571003646	intermolecular recognition site; other site
665571003647	dimerization interface [polypeptide binding]; other site
665571003648	Response regulator receiver domain; Region: Response_reg; pfam00072
665571003649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571003650	active site
665571003651	phosphorylation site [posttranslational modification]
665571003652	intermolecular recognition site; other site
665571003653	dimerization interface [polypeptide binding]; other site
665571003654	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
665571003655	elongation factor G; Reviewed; Region: PRK12739
665571003656	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
665571003657	G1 box; other site
665571003658	putative GEF interaction site [polypeptide binding]; other site
665571003659	GTP/Mg2+ binding site [chemical binding]; other site
665571003660	Switch I region; other site
665571003661	G2 box; other site
665571003662	G3 box; other site
665571003663	Switch II region; other site
665571003664	G4 box; other site
665571003665	G5 box; other site
665571003666	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
665571003667	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
665571003668	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
665571003669	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
665571003670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
665571003671	dimerization interface [polypeptide binding]; other site
665571003672	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571003673	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571003674	dimer interface [polypeptide binding]; other site
665571003675	putative CheW interface [polypeptide binding]; other site
665571003676	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
665571003677	elongation factor G; Reviewed; Region: PRK12740
665571003678	G1 box; other site
665571003679	putative GEF interaction site [polypeptide binding]; other site
665571003680	GTP/Mg2+ binding site [chemical binding]; other site
665571003681	Switch I region; other site
665571003682	G2 box; other site
665571003683	G3 box; other site
665571003684	Switch II region; other site
665571003685	G4 box; other site
665571003686	G5 box; other site
665571003687	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
665571003688	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
665571003689	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
665571003690	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
665571003691	dimer interface [polypeptide binding]; other site
665571003692	Citrate synthase; Region: Citrate_synt; pfam00285
665571003693	active site
665571003694	citrylCoA binding site [chemical binding]; other site
665571003695	oxalacetate/citrate binding site [chemical binding]; other site
665571003696	coenzyme A binding site [chemical binding]; other site
665571003697	catalytic triad [active]
665571003698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571003699	S-adenosylmethionine binding site [chemical binding]; other site
665571003700	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
665571003701	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
665571003702	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
665571003703	ATP binding site [chemical binding]; other site
665571003704	putative Mg++ binding site [ion binding]; other site
665571003705	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
665571003706	nucleotide binding region [chemical binding]; other site
665571003707	ATP-binding site [chemical binding]; other site
665571003708	TRCF domain; Region: TRCF; pfam03461
665571003709	PilZ domain; Region: PilZ; pfam07238
665571003710	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
665571003711	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571003712	FeS/SAM binding site; other site
665571003713	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
665571003714	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
665571003715	MULE transposase domain; Region: MULE; pfam10551
665571003716	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571003717	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
665571003718	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
665571003719	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
665571003720	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571003721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571003722	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
665571003723	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
665571003724	active site
665571003725	catalytic tetrad [active]
665571003726	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571003727	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571003728	putative substrate translocation pore; other site
665571003729	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
665571003730	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
665571003731	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
665571003732	dimer interface [polypeptide binding]; other site
665571003733	active site
665571003734	metal binding site [ion binding]; metal-binding site
665571003735	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
665571003736	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
665571003737	short chain dehydrogenase; Provisional; Region: PRK08339
665571003738	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
665571003739	putative NAD(P) binding site [chemical binding]; other site
665571003740	putative active site [active]
665571003741	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
665571003742	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
665571003743	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
665571003744	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
665571003745	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
665571003746	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
665571003747	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
665571003748	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
665571003749	Walker A/P-loop; other site
665571003750	ATP binding site [chemical binding]; other site
665571003751	Q-loop/lid; other site
665571003752	ABC transporter signature motif; other site
665571003753	Walker B; other site
665571003754	D-loop; other site
665571003755	H-loop/switch region; other site
665571003756	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
665571003757	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
665571003758	reverse gyrase; Reviewed; Region: PRK09401
665571003759	HEAT repeats; Region: HEAT_2; pfam13646
665571003760	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
665571003761	active site
665571003762	catalytic site [active]
665571003763	substrate binding site [chemical binding]; other site
665571003764	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
665571003765	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
665571003766	active site
665571003767	substrate binding site [chemical binding]; other site
665571003768	metal binding site [ion binding]; metal-binding site
665571003769	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
665571003770	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
665571003771	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
665571003772	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
665571003773	active site
665571003774	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
665571003775	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
665571003776	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
665571003777	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
665571003778	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
665571003779	Protein of unknown function DUF72; Region: DUF72; pfam01904
665571003780	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
665571003781	GcpE protein; Region: GcpE; pfam04551
665571003782	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
665571003783	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
665571003784	V-type ATP synthase subunit K; Validated; Region: PRK06649
665571003785	V-type ATP synthase subunit I; Validated; Region: PRK05771
665571003786	V-type ATP synthase subunit D; Provisional; Region: PRK02195
665571003787	V-type ATP synthase subunit B; Provisional; Region: PRK02118
665571003788	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
665571003789	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
665571003790	Walker A motif homologous position; other site
665571003791	Walker B motif; other site
665571003792	V-type ATP synthase subunit A; Provisional; Region: PRK04192
665571003793	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
665571003794	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
665571003795	Walker A motif/ATP binding site; other site
665571003796	Walker B motif; other site
665571003797	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
665571003798	V-type ATP synthase subunit E; Provisional; Region: PRK01558
665571003799	V-type ATP synthase subunit E; Provisional; Region: PRK01005
665571003800	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
665571003801	dimerization interface [polypeptide binding]; other site
665571003802	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
665571003803	cyclase homology domain; Region: CHD; cd07302
665571003804	nucleotidyl binding site; other site
665571003805	metal binding site [ion binding]; metal-binding site
665571003806	dimer interface [polypeptide binding]; other site
665571003807	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
665571003808	biotin synthase; Region: bioB; TIGR00433
665571003809	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571003810	FeS/SAM binding site; other site
665571003811	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
665571003812	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
665571003813	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
665571003814	classical (c) SDRs; Region: SDR_c; cd05233
665571003815	NAD(P) binding site [chemical binding]; other site
665571003816	active site
665571003817	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
665571003818	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
665571003819	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
665571003820	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
665571003821	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
665571003822	Hemerythrin; Region: Hemerythrin; cd12107
665571003823	Fe binding site [ion binding]; other site
665571003824	cytidylate kinase; Provisional; Region: PRK04182
665571003825	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
665571003826	CMP-binding site; other site
665571003827	The sites determining sugar specificity; other site
665571003828	hypothetical protein; Provisional; Region: PRK11820
665571003829	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
665571003830	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
665571003831	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
665571003832	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
665571003833	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
665571003834	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
665571003835	Predicted ATPase [General function prediction only]; Region: COG4637
665571003836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571003837	Walker A/P-loop; other site
665571003838	ATP binding site [chemical binding]; other site
665571003839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571003840	putative substrate translocation pore; other site
665571003841	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
665571003842	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
665571003843	dimer interface [polypeptide binding]; other site
665571003844	active site
665571003845	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
665571003846	YibE/F-like protein; Region: YibE_F; pfam07907
665571003847	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
665571003848	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
665571003849	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
665571003850	putative active site [active]
665571003851	putative metal binding site [ion binding]; other site
665571003852	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
665571003853	4Fe-4S binding domain; Region: Fer4; pfam00037
665571003854	4Fe-4S binding domain; Region: Fer4; cl02805
665571003855	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
665571003856	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
665571003857	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
665571003858	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
665571003859	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
665571003860	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
665571003861	Putative Fe-S cluster; Region: FeS; cl17515
665571003862	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
665571003863	dimer interface [polypeptide binding]; other site
665571003864	[2Fe-2S] cluster binding site [ion binding]; other site
665571003865	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
665571003866	Clp amino terminal domain; Region: Clp_N; pfam02861
665571003867	Clp amino terminal domain; Region: Clp_N; pfam02861
665571003868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003869	Walker A motif; other site
665571003870	ATP binding site [chemical binding]; other site
665571003871	Walker B motif; other site
665571003872	arginine finger; other site
665571003873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003874	Walker A motif; other site
665571003875	ATP binding site [chemical binding]; other site
665571003876	Walker B motif; other site
665571003877	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
665571003878	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
665571003879	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
665571003880	ADP binding site [chemical binding]; other site
665571003881	phosphagen binding site; other site
665571003882	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
665571003883	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571003884	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571003885	FtsX-like permease family; Region: FtsX; pfam02687
665571003886	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571003887	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
665571003888	Walker A/P-loop; other site
665571003889	ATP binding site [chemical binding]; other site
665571003890	Q-loop/lid; other site
665571003891	ABC transporter signature motif; other site
665571003892	Walker B; other site
665571003893	D-loop; other site
665571003894	H-loop/switch region; other site
665571003895	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571003896	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
665571003897	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
665571003898	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
665571003899	PEGA domain; Region: PEGA; pfam08308
665571003900	peptide chain release factor 2; Validated; Region: prfB; PRK00578
665571003901	This domain is found in peptide chain release factors; Region: PCRF; smart00937
665571003902	RF-1 domain; Region: RF-1; pfam00472
665571003903	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571003904	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
665571003905	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
665571003906	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
665571003907	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
665571003908	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
665571003909	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
665571003910	dimerization interface [polypeptide binding]; other site
665571003911	ATP binding site [chemical binding]; other site
665571003912	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
665571003913	dimerization interface [polypeptide binding]; other site
665571003914	ATP binding site [chemical binding]; other site
665571003915	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
665571003916	putative active site [active]
665571003917	catalytic triad [active]
665571003918	AIR carboxylase; Region: AIRC; pfam00731
665571003919	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
665571003920	amidophosphoribosyltransferase; Provisional; Region: PRK05793
665571003921	tetramer interface [polypeptide binding]; other site
665571003922	active site
665571003923	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
665571003924	active site
665571003925	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
665571003926	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
665571003927	dimerization interface [polypeptide binding]; other site
665571003928	putative ATP binding site [chemical binding]; other site
665571003929	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
665571003930	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
665571003931	active site
665571003932	substrate binding site [chemical binding]; other site
665571003933	cosubstrate binding site; other site
665571003934	catalytic site [active]
665571003935	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
665571003936	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
665571003937	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
665571003938	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
665571003939	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
665571003940	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
665571003941	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
665571003942	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
665571003943	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
665571003944	FAD binding pocket [chemical binding]; other site
665571003945	FAD binding motif [chemical binding]; other site
665571003946	phosphate binding motif [ion binding]; other site
665571003947	beta-alpha-beta structure motif; other site
665571003948	NAD binding pocket [chemical binding]; other site
665571003949	Iron coordination center [ion binding]; other site
665571003950	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
665571003951	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
665571003952	Clp amino terminal domain; Region: Clp_N; pfam02861
665571003953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003954	Walker A motif; other site
665571003955	ATP binding site [chemical binding]; other site
665571003956	Walker B motif; other site
665571003957	arginine finger; other site
665571003958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571003959	Walker A motif; other site
665571003960	ATP binding site [chemical binding]; other site
665571003961	Walker B motif; other site
665571003962	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
665571003963	Uncharacterized conserved protein [Function unknown]; Region: COG2127
665571003964	TPR repeat; Region: TPR_11; pfam13414
665571003965	Uncharacterized conserved protein [Function unknown]; Region: COG3391
665571003966	NHL repeat; Region: NHL; pfam01436
665571003967	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
665571003968	von Willebrand factor type A domain; Region: VWA_2; pfam13519
665571003969	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003970	binding surface
665571003971	TPR motif; other site
665571003972	TPR repeat; Region: TPR_11; pfam13414
665571003973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571003974	binding surface
665571003975	TPR motif; other site
665571003976	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571003977	Survival protein SurE; Region: SurE; cl00448
665571003978	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
665571003979	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
665571003980	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
665571003981	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
665571003982	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
665571003983	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
665571003984	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
665571003985	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
665571003986	motif 1; other site
665571003987	dimer interface [polypeptide binding]; other site
665571003988	active site
665571003989	motif 2; other site
665571003990	motif 3; other site
665571003991	elongation factor P; Validated; Region: PRK00529
665571003992	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
665571003993	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
665571003994	RNA binding site [nucleotide binding]; other site
665571003995	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
665571003996	RNA binding site [nucleotide binding]; other site
665571003997	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
665571003998	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
665571003999	dimer interface [polypeptide binding]; other site
665571004000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004001	catalytic residue [active]
665571004002	Predicted transcriptional regulator [Transcription]; Region: COG1959
665571004003	Transcriptional regulator; Region: Rrf2; cl17282
665571004004	FIST N domain; Region: FIST; pfam08495
665571004005	FIST C domain; Region: FIST_C; pfam10442
665571004006	Mechanosensitive ion channel; Region: MS_channel; pfam00924
665571004007	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
665571004008	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
665571004009	active site
665571004010	dimer interface [polypeptide binding]; other site
665571004011	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
665571004012	active site
665571004013	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
665571004014	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
665571004015	catalytic site [active]
665571004016	NAD-dependent deacetylase; Provisional; Region: PRK00481
665571004017	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
665571004018	CAAX protease self-immunity; Region: Abi; pfam02517
665571004019	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
665571004020	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004021	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571004022	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
665571004023	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
665571004024	active site
665571004025	homodimer interface [polypeptide binding]; other site
665571004026	catalytic site [active]
665571004027	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
665571004028	ferredoxin; Validated; Region: PRK07118
665571004029	Putative Fe-S cluster; Region: FeS; cl17515
665571004030	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004031	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004032	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
665571004033	SLBB domain; Region: SLBB; pfam10531
665571004034	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
665571004035	FMN-binding domain; Region: FMN_bind; cl01081
665571004036	electron transport complex RsxE subunit; Provisional; Region: PRK12405
665571004037	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
665571004038	hypothetical protein; Reviewed; Region: PRK00024
665571004039	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
665571004040	MPN+ (JAMM) motif; other site
665571004041	Zinc-binding site [ion binding]; other site
665571004042	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
665571004043	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
665571004044	homodimer interface [polypeptide binding]; other site
665571004045	substrate-cofactor binding pocket; other site
665571004046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004047	catalytic residue [active]
665571004048	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
665571004049	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
665571004050	dimer interface [polypeptide binding]; other site
665571004051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004052	catalytic residue [active]
665571004053	Rrf2 family protein; Region: rrf2_super; TIGR00738
665571004054	Transcriptional regulator; Region: Rrf2; pfam02082
665571004055	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
665571004056	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
665571004057	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
665571004058	ligand binding site [chemical binding]; other site
665571004059	TM2 domain; Region: TM2; pfam05154
665571004060	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
665571004061	FliG C-terminal domain; Region: FliG_C; pfam01706
665571004062	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
665571004063	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
665571004064	DNA binding residues [nucleotide binding]
665571004065	GTP-binding protein Der; Reviewed; Region: PRK00093
665571004066	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
665571004067	G1 box; other site
665571004068	GTP/Mg2+ binding site [chemical binding]; other site
665571004069	G2 box; other site
665571004070	Switch I region; other site
665571004071	G3 box; other site
665571004072	Switch II region; other site
665571004073	G4 box; other site
665571004074	G5 box; other site
665571004075	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
665571004076	G1 box; other site
665571004077	GTP/Mg2+ binding site [chemical binding]; other site
665571004078	Switch I region; other site
665571004079	G2 box; other site
665571004080	G3 box; other site
665571004081	Switch II region; other site
665571004082	G4 box; other site
665571004083	G5 box; other site
665571004084	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
665571004085	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
665571004086	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
665571004087	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
665571004088	Sporulation and spore germination; Region: Germane; pfam10646
665571004089	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
665571004090	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
665571004091	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
665571004092	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
665571004093	putative active site [active]
665571004094	metal binding site [ion binding]; metal-binding site
665571004095	homodimer binding site [polypeptide binding]; other site
665571004096	phosphodiesterase; Provisional; Region: PRK12704
665571004097	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571004098	Zn2+ binding site [ion binding]; other site
665571004099	Mg2+ binding site [ion binding]; other site
665571004100	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
665571004101	active site
665571004102	dimer interface [polypeptide binding]; other site
665571004103	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
665571004104	active site
665571004105	dimer interface [polypeptide binding]; other site
665571004106	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
665571004107	rRNA interaction site [nucleotide binding]; other site
665571004108	S8 interaction site; other site
665571004109	putative laminin-1 binding site; other site
665571004110	elongation factor Ts; Provisional; Region: tsf; PRK09377
665571004111	UBA/TS-N domain; Region: UBA; pfam00627
665571004112	Elongation factor TS; Region: EF_TS; pfam00889
665571004113	Elongation factor TS; Region: EF_TS; pfam00889
665571004114	ribosome recycling factor; Reviewed; Region: frr; PRK00083
665571004115	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
665571004116	hinge region; other site
665571004117	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
665571004118	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
665571004119	catalytic residue [active]
665571004120	putative FPP diphosphate  binding site; other site
665571004121	putative FPP binding hydrophobic cleft; other site
665571004122	dimer interface [polypeptide binding]; other site
665571004123	putative IPP diphosphate binding site; other site
665571004124	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
665571004125	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
665571004126	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
665571004127	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
665571004128	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
665571004129	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
665571004130	RIP metalloprotease RseP; Region: TIGR00054
665571004131	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
665571004132	active site
665571004133	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
665571004134	protein binding site [polypeptide binding]; other site
665571004135	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
665571004136	protein binding site [polypeptide binding]; other site
665571004137	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
665571004138	putative substrate binding region [chemical binding]; other site
665571004139	FOG: WD40 repeat [General function prediction only]; Region: COG2319
665571004140	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
665571004141	replicative DNA helicase; Region: DnaB; TIGR00665
665571004142	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
665571004143	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
665571004144	Walker A motif; other site
665571004145	ATP binding site [chemical binding]; other site
665571004146	Walker B motif; other site
665571004147	DNA binding loops [nucleotide binding]
665571004148	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
665571004149	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
665571004150	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
665571004151	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
665571004152	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
665571004153	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
665571004154	dimer interface [polypeptide binding]; other site
665571004155	ssDNA binding site [nucleotide binding]; other site
665571004156	tetramer (dimer of dimers) interface [polypeptide binding]; other site
665571004157	Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360
665571004158	Nif-specific regulatory protein; Region: nifA; TIGR01817
665571004159	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
665571004160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571004161	Walker A motif; other site
665571004162	ATP binding site [chemical binding]; other site
665571004163	Walker B motif; other site
665571004164	arginine finger; other site
665571004165	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
665571004166	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
665571004167	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
665571004168	Nitrogen regulatory protein P-II; Region: P-II; smart00938
665571004169	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
665571004170	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
665571004171	inhibitor-cofactor binding pocket; inhibition site
665571004172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004173	catalytic residue [active]
665571004174	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
665571004175	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571004176	catalytic residue [active]
665571004177	Protein of unknown function (DUF452); Region: DUF452; cl01062
665571004178	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
665571004179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571004180	S-adenosylmethionine binding site [chemical binding]; other site
665571004181	AAA domain; Region: AAA_26; pfam13500
665571004182	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
665571004183	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
665571004184	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
665571004185	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
665571004186	metal binding triad; other site
665571004187	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
665571004188	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
665571004189	metal binding triad; other site
665571004190	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
665571004191	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
665571004192	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
665571004193	nucleotide binding site [chemical binding]; other site
665571004194	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
665571004195	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
665571004196	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
665571004197	active site
665571004198	MULE transposase domain; Region: MULE; pfam10551
665571004199	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571004200	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
665571004201	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
665571004202	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
665571004203	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
665571004204	oligomer interface [polypeptide binding]; other site
665571004205	metal binding site [ion binding]; metal-binding site
665571004206	metal binding site [ion binding]; metal-binding site
665571004207	Cl binding site [ion binding]; other site
665571004208	aspartate ring; other site
665571004209	basic sphincter; other site
665571004210	putative hydrophobic gate; other site
665571004211	periplasmic entrance; other site
665571004212	argininosuccinate lyase; Provisional; Region: PRK00855
665571004213	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
665571004214	active sites [active]
665571004215	tetramer interface [polypeptide binding]; other site
665571004216	phytoene desaturase; Region: crtI_fam; TIGR02734
665571004217	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
665571004218	Clp amino terminal domain; Region: Clp_N; pfam02861
665571004219	Clp amino terminal domain; Region: Clp_N; pfam02861
665571004220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571004221	Walker A motif; other site
665571004222	ATP binding site [chemical binding]; other site
665571004223	Walker B motif; other site
665571004224	arginine finger; other site
665571004225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571004226	Walker A motif; other site
665571004227	ATP binding site [chemical binding]; other site
665571004228	Walker B motif; other site
665571004229	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
665571004230	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
665571004231	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
665571004232	catalytic triad [active]
665571004233	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571004234	active site
665571004235	NTP binding site [chemical binding]; other site
665571004236	metal binding triad [ion binding]; metal-binding site
665571004237	antibiotic binding site [chemical binding]; other site
665571004238	Protein of unknown function DUF86; Region: DUF86; cl01031
665571004239	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
665571004240	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
665571004241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004242	homodimer interface [polypeptide binding]; other site
665571004243	catalytic residue [active]
665571004244	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
665571004245	cobalt transport protein CbiM; Validated; Region: PRK06265
665571004246	PDGLE domain; Region: PDGLE; pfam13190
665571004247	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571004248	MULE transposase domain; Region: MULE; pfam10551
665571004249	LemA family; Region: LemA; pfam04011
665571004250	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
665571004251	Repair protein; Region: Repair_PSII; pfam04536
665571004252	Repair protein; Region: Repair_PSII; cl01535
665571004253	Cupin domain; Region: Cupin_2; pfam07883
665571004254	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
665571004255	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
665571004256	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
665571004257	DctM-like transporters; Region: DctM; pfam06808
665571004258	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
665571004259	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
665571004260	metal ion-dependent adhesion site (MIDAS); other site
665571004261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571004262	Walker A motif; other site
665571004263	ATP binding site [chemical binding]; other site
665571004264	Walker B motif; other site
665571004265	arginine finger; other site
665571004266	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
665571004267	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
665571004268	Predicted transcriptional regulators [Transcription]; Region: COG1725
665571004269	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
665571004270	DNA-binding site [nucleotide binding]; DNA binding site
665571004271	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
665571004272	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571004273	Walker A/P-loop; other site
665571004274	ATP binding site [chemical binding]; other site
665571004275	Q-loop/lid; other site
665571004276	ABC transporter signature motif; other site
665571004277	Walker B; other site
665571004278	D-loop; other site
665571004279	H-loop/switch region; other site
665571004280	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
665571004281	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
665571004282	ZIP Zinc transporter; Region: Zip; pfam02535
665571004283	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
665571004284	ribonuclease PH; Reviewed; Region: rph; PRK00173
665571004285	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
665571004286	oligomer interface [polypeptide binding]; other site
665571004287	RNA binding site [nucleotide binding]; other site
665571004288	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571004289	active site
665571004290	NTP binding site [chemical binding]; other site
665571004291	metal binding triad [ion binding]; metal-binding site
665571004292	antibiotic binding site [chemical binding]; other site
665571004293	HEPN domain; Region: HEPN; pfam05168
665571004294	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
665571004295	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571004296	Walker A/P-loop; other site
665571004297	ATP binding site [chemical binding]; other site
665571004298	Q-loop/lid; other site
665571004299	ABC transporter signature motif; other site
665571004300	Walker B; other site
665571004301	D-loop; other site
665571004302	H-loop/switch region; other site
665571004303	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
665571004304	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
665571004305	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
665571004306	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
665571004307	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
665571004308	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
665571004309	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
665571004310	catalytic loop [active]
665571004311	iron binding site [ion binding]; other site
665571004312	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
665571004313	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
665571004314	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004315	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
665571004316	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
665571004317	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
665571004318	dimer interface [polypeptide binding]; other site
665571004319	[2Fe-2S] cluster binding site [ion binding]; other site
665571004320	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
665571004321	SLBB domain; Region: SLBB; pfam10531
665571004322	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
665571004323	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004324	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
665571004325	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004326	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
665571004327	dimer interface [polypeptide binding]; other site
665571004328	[2Fe-2S] cluster binding site [ion binding]; other site
665571004329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571004330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571004331	ATP binding site [chemical binding]; other site
665571004332	Mg2+ binding site [ion binding]; other site
665571004333	G-X-G motif; other site
665571004334	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
665571004335	HIRAN domain; Region: HIRAN; cl07418
665571004336	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
665571004337	putative dimer interface [polypeptide binding]; other site
665571004338	[2Fe-2S] cluster binding site [ion binding]; other site
665571004339	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
665571004340	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
665571004341	CoA binding domain; Region: CoA_binding; smart00881
665571004342	DRTGG domain; Region: DRTGG; pfam07085
665571004343	FOG: CBS domain [General function prediction only]; Region: COG0517
665571004344	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
665571004345	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
665571004346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571004347	ATP binding site [chemical binding]; other site
665571004348	G-X-G motif; other site
665571004349	DRTGG domain; Region: DRTGG; pfam07085
665571004350	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
665571004351	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
665571004352	PHP-associated; Region: PHP_C; pfam13263
665571004353	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
665571004354	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
665571004355	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
665571004356	active site
665571004357	catalytic residues [active]
665571004358	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571004359	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571004360	DNA binding site [nucleotide binding]
665571004361	domain linker motif; other site
665571004362	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571004363	ligand binding site [chemical binding]; other site
665571004364	dimerization interface [polypeptide binding]; other site
665571004365	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
665571004366	homodimer interface [polypeptide binding]; other site
665571004367	Ca binding site [ion binding]; other site
665571004368	ligand binding site I [chemical binding]; other site
665571004369	ligand binding site II [chemical binding]; other site
665571004370	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
665571004371	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
665571004372	active site
665571004373	catalytic residues [active]
665571004374	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571004375	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571004376	DNA binding site [nucleotide binding]
665571004377	domain linker motif; other site
665571004378	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571004379	dimerization interface [polypeptide binding]; other site
665571004380	ligand binding site [chemical binding]; other site
665571004381	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
665571004382	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
665571004383	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571004384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004385	dimer interface [polypeptide binding]; other site
665571004386	conserved gate region; other site
665571004387	putative PBP binding loops; other site
665571004388	ABC-ATPase subunit interface; other site
665571004389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004390	dimer interface [polypeptide binding]; other site
665571004391	conserved gate region; other site
665571004392	putative PBP binding loops; other site
665571004393	ABC-ATPase subunit interface; other site
665571004394	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571004395	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571004396	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571004397	Probable beta-xylosidase; Provisional; Region: PLN03080
665571004398	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
665571004399	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
665571004400	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
665571004401	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
665571004402	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
665571004403	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
665571004404	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
665571004405	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
665571004406	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
665571004407	NAD binding site [chemical binding]; other site
665571004408	sugar binding site [chemical binding]; other site
665571004409	divalent metal binding site [ion binding]; other site
665571004410	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
665571004411	dimer interface [polypeptide binding]; other site
665571004412	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
665571004413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571004414	S-adenosylmethionine binding site [chemical binding]; other site
665571004415	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
665571004416	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
665571004417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571004418	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571004419	putative substrate translocation pore; other site
665571004420	HEAT repeats; Region: HEAT_2; pfam13646
665571004421	Peptidase family M48; Region: Peptidase_M48; cl12018
665571004422	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
665571004423	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
665571004424	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
665571004425	active site
665571004426	HIGH motif; other site
665571004427	nucleotide binding site [chemical binding]; other site
665571004428	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
665571004429	KMSKS motif; other site
665571004430	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
665571004431	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
665571004432	human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339
665571004433	putative NAD(P) binding site [chemical binding]; other site
665571004434	homodimer interface [polypeptide binding]; other site
665571004435	active site
665571004436	substrate binding site [chemical binding]; other site
665571004437	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
665571004438	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
665571004439	NAD(P) binding site [chemical binding]; other site
665571004440	catalytic residues [active]
665571004441	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
665571004442	Part of AAA domain; Region: AAA_19; pfam13245
665571004443	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
665571004444	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
665571004445	Family description; Region: UvrD_C_2; pfam13538
665571004446	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
665571004447	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571004448	Zn2+ binding site [ion binding]; other site
665571004449	Mg2+ binding site [ion binding]; other site
665571004450	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
665571004451	Cache domain; Region: Cache_1; pfam02743
665571004452	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571004453	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571004454	metal binding site [ion binding]; metal-binding site
665571004455	active site
665571004456	I-site; other site
665571004457	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
665571004458	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
665571004459	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
665571004460	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
665571004461	acyl-activating enzyme (AAE) consensus motif; other site
665571004462	acyl-activating enzyme (AAE) consensus motif; other site
665571004463	putative AMP binding site [chemical binding]; other site
665571004464	putative active site [active]
665571004465	putative CoA binding site [chemical binding]; other site
665571004466	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
665571004467	PAS fold; Region: PAS_3; pfam08447
665571004468	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571004469	metal binding site [ion binding]; metal-binding site
665571004470	active site
665571004471	I-site; other site
665571004472	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
665571004473	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571004474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571004475	active site
665571004476	phosphorylation site [posttranslational modification]
665571004477	intermolecular recognition site; other site
665571004478	dimerization interface [polypeptide binding]; other site
665571004479	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
665571004480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
665571004481	ATP binding site [chemical binding]; other site
665571004482	putative Mg++ binding site [ion binding]; other site
665571004483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571004484	putative active site [active]
665571004485	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571004486	heme pocket [chemical binding]; other site
665571004487	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571004488	dimer interface [polypeptide binding]; other site
665571004489	phosphorylation site [posttranslational modification]
665571004490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571004491	ATP binding site [chemical binding]; other site
665571004492	Mg2+ binding site [ion binding]; other site
665571004493	G-X-G motif; other site
665571004494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571004495	Response regulator receiver domain; Region: Response_reg; pfam00072
665571004496	active site
665571004497	phosphorylation site [posttranslational modification]
665571004498	intermolecular recognition site; other site
665571004499	dimerization interface [polypeptide binding]; other site
665571004500	Response regulator receiver domain; Region: Response_reg; pfam00072
665571004501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571004502	active site
665571004503	phosphorylation site [posttranslational modification]
665571004504	intermolecular recognition site; other site
665571004505	dimerization interface [polypeptide binding]; other site
665571004506	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
665571004507	putative binding surface; other site
665571004508	active site
665571004509	Response regulator receiver domain; Region: Response_reg; pfam00072
665571004510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571004511	active site
665571004512	phosphorylation site [posttranslational modification]
665571004513	intermolecular recognition site; other site
665571004514	dimerization interface [polypeptide binding]; other site
665571004515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571004516	Response regulator receiver domain; Region: Response_reg; pfam00072
665571004517	active site
665571004518	phosphorylation site [posttranslational modification]
665571004519	intermolecular recognition site; other site
665571004520	dimerization interface [polypeptide binding]; other site
665571004521	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571004522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571004523	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
665571004524	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
665571004525	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
665571004526	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
665571004527	active site
665571004528	substrate binding site [chemical binding]; other site
665571004529	metal binding site [ion binding]; metal-binding site
665571004530	TspO/MBR family; Region: TspO_MBR; pfam03073
665571004531	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
665571004532	endonuclease III; Region: ENDO3c; smart00478
665571004533	minor groove reading motif; other site
665571004534	helix-hairpin-helix signature motif; other site
665571004535	substrate binding pocket [chemical binding]; other site
665571004536	active site
665571004537	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
665571004538	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
665571004539	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571004540	motif II; other site
665571004541	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
665571004542	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
665571004543	active site
665571004544	HIGH motif; other site
665571004545	dimer interface [polypeptide binding]; other site
665571004546	KMSKS motif; other site
665571004547	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
665571004548	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
665571004549	potential frameshift: common BLAST hit: gi|256828195|ref|YP_003156923.1| para-aminobenzoate synthase, subunit I
665571004550	aminodeoxychorismate synthase; Provisional; Region: PRK07508
665571004551	chorismate binding enzyme; Region: Chorismate_bind; cl10555
665571004552	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
665571004553	substrate-cofactor binding pocket; other site
665571004554	homodimer interface [polypeptide binding]; other site
665571004555	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
665571004556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004557	catalytic residue [active]
665571004558	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
665571004559	Domain of unknown function DUF20; Region: UPF0118; pfam01594
665571004560	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
665571004561	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
665571004562	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
665571004563	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
665571004564	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
665571004565	CoA binding domain; Region: CoA_binding; pfam02629
665571004566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571004567	Walker A/P-loop; other site
665571004568	ATP binding site [chemical binding]; other site
665571004569	ABC transporter; Region: ABC_tran; pfam00005
665571004570	Q-loop/lid; other site
665571004571	ABC transporter signature motif; other site
665571004572	Walker B; other site
665571004573	D-loop; other site
665571004574	H-loop/switch region; other site
665571004575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004576	putative PBP binding loops; other site
665571004577	ABC-ATPase subunit interface; other site
665571004578	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
665571004579	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
665571004580	active site
665571004581	HIGH motif; other site
665571004582	dimer interface [polypeptide binding]; other site
665571004583	KMSKS motif; other site
665571004584	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
665571004585	RNA binding surface [nucleotide binding]; other site
665571004586	glycyl-tRNA synthetase; Provisional; Region: PRK04173
665571004587	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
665571004588	dimer interface [polypeptide binding]; other site
665571004589	motif 1; other site
665571004590	active site
665571004591	motif 2; other site
665571004592	motif 3; other site
665571004593	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
665571004594	anticodon binding site; other site
665571004595	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
665571004596	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
665571004597	HIGH motif; other site
665571004598	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
665571004599	active site
665571004600	KMSKS motif; other site
665571004601	aminotransferase AlaT; Validated; Region: PRK09265
665571004602	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
665571004603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571004604	homodimer interface [polypeptide binding]; other site
665571004605	catalytic residue [active]
665571004606	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
665571004607	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571004608	Zn2+ binding site [ion binding]; other site
665571004609	Mg2+ binding site [ion binding]; other site
665571004610	Membrane transport protein; Region: Mem_trans; cl09117
665571004611	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571004612	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
665571004613	LVIVD repeat; Region: LVIVD; pfam08309
665571004614	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571004615	putative DNA binding site [nucleotide binding]; other site
665571004616	putative Zn2+ binding site [ion binding]; other site
665571004617	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
665571004618	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
665571004619	BioY family; Region: BioY; pfam02632
665571004620	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
665571004621	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
665571004622	Walker A/P-loop; other site
665571004623	ATP binding site [chemical binding]; other site
665571004624	Q-loop/lid; other site
665571004625	ABC transporter signature motif; other site
665571004626	Walker B; other site
665571004627	D-loop; other site
665571004628	H-loop/switch region; other site
665571004629	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
665571004630	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
665571004631	Soluble P-type ATPase [General function prediction only]; Region: COG4087
665571004632	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571004633	dimerization interface [polypeptide binding]; other site
665571004634	putative DNA binding site [nucleotide binding]; other site
665571004635	putative Zn2+ binding site [ion binding]; other site
665571004636	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571004637	Domain of unknown function (DUF303); Region: DUF303; pfam03629
665571004638	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
665571004639	TrkA-N domain; Region: TrkA_N; pfam02254
665571004640	TrkA-C domain; Region: TrkA_C; pfam02080
665571004641	TrkA-N domain; Region: TrkA_N; pfam02254
665571004642	TrkA-C domain; Region: TrkA_C; pfam02080
665571004643	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
665571004644	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
665571004645	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
665571004646	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
665571004647	active site
665571004648	catalytic motif [active]
665571004649	Zn binding site [ion binding]; other site
665571004650	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
665571004651	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
665571004652	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
665571004653	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
665571004654	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
665571004655	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
665571004656	Predicted peptidase [General function prediction only]; Region: COG4099
665571004657	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
665571004658	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
665571004659	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
665571004660	Cupin domain; Region: Cupin_2; cl17218
665571004661	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
665571004662	Transcriptional regulator; Region: Rrf2; cl17282
665571004663	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571004664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571004665	Major Facilitator Superfamily; Region: MFS_1; pfam07690
665571004666	putative substrate translocation pore; other site
665571004667	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
665571004668	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
665571004669	Walker A/P-loop; other site
665571004670	ATP binding site [chemical binding]; other site
665571004671	Q-loop/lid; other site
665571004672	ABC transporter signature motif; other site
665571004673	Walker B; other site
665571004674	D-loop; other site
665571004675	H-loop/switch region; other site
665571004676	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
665571004677	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
665571004678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571004679	D-loop; other site
665571004680	H-loop/switch region; other site
665571004681	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
665571004682	Predicted transcriptional regulator [Transcription]; Region: COG4189
665571004683	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571004684	dimerization interface [polypeptide binding]; other site
665571004685	putative DNA binding site [nucleotide binding]; other site
665571004686	putative Zn2+ binding site [ion binding]; other site
665571004687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
665571004688	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
665571004689	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
665571004690	substrate binding site [chemical binding]; other site
665571004691	active site
665571004692	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
665571004693	intermolecular salt bridges; other site
665571004694	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
665571004695	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
665571004696	active site
665571004697	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
665571004698	substrate binding site [chemical binding]; other site
665571004699	active site
665571004700	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
665571004701	active site
665571004702	metal binding site [ion binding]; metal-binding site
665571004703	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
665571004704	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
665571004705	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
665571004706	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
665571004707	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
665571004708	Septum formation initiator; Region: DivIC; pfam04977
665571004709	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
665571004710	LysE type translocator; Region: LysE; cl00565
665571004711	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
665571004712	GTP/Mg2+ binding site [chemical binding]; other site
665571004713	G4 box; other site
665571004714	G5 box; other site
665571004715	G1 box; other site
665571004716	Switch I region; other site
665571004717	G2 box; other site
665571004718	Response regulator receiver domain; Region: Response_reg; pfam00072
665571004719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571004720	active site
665571004721	phosphorylation site [posttranslational modification]
665571004722	intermolecular recognition site; other site
665571004723	dimerization interface [polypeptide binding]; other site
665571004724	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
665571004725	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
665571004726	DXD motif; other site
665571004727	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
665571004728	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
665571004729	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
665571004730	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
665571004731	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
665571004732	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
665571004733	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
665571004734	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
665571004735	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571004736	motif I; other site
665571004737	motif II; other site
665571004738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571004739	S-adenosylmethionine binding site [chemical binding]; other site
665571004740	Domain of unknown function DUF302; Region: DUF302; cl01364
665571004741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571004742	S-adenosylmethionine binding site [chemical binding]; other site
665571004743	Short C-terminal domain; Region: SHOCT; pfam09851
665571004744	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
665571004745	metal-binding site [ion binding]
665571004746	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
665571004747	metal-binding site [ion binding]
665571004748	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
665571004749	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
665571004750	metal-binding site [ion binding]
665571004751	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
665571004752	Soluble P-type ATPase [General function prediction only]; Region: COG4087
665571004753	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
665571004754	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
665571004755	Ca binding site [ion binding]; other site
665571004756	active site
665571004757	catalytic site [active]
665571004758	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571004759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004760	dimer interface [polypeptide binding]; other site
665571004761	conserved gate region; other site
665571004762	putative PBP binding loops; other site
665571004763	ABC-ATPase subunit interface; other site
665571004764	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
665571004765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004766	conserved gate region; other site
665571004767	dimer interface [polypeptide binding]; other site
665571004768	putative PBP binding loops; other site
665571004769	ABC-ATPase subunit interface; other site
665571004770	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
665571004771	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571004772	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571004773	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571004774	DNA binding site [nucleotide binding]
665571004775	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571004776	ligand binding site [chemical binding]; other site
665571004777	dimerization interface [polypeptide binding]; other site
665571004778	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
665571004779	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
665571004780	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
665571004781	dimer interface [polypeptide binding]; other site
665571004782	active site
665571004783	metal binding site [ion binding]; metal-binding site
665571004784	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
665571004785	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
665571004786	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
665571004787	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
665571004788	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
665571004789	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
665571004790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
665571004791	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
665571004792	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
665571004793	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
665571004794	active site residue [active]
665571004795	SirA_RHOD_Pry_redox.    SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420
665571004796	CPxP  motif; other site
665571004797	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
665571004798	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
665571004799	EamA-like transporter family; Region: EamA; pfam00892
665571004800	EamA-like transporter family; Region: EamA; pfam00892
665571004801	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
665571004802	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
665571004803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571004804	PAS domain; Region: PAS_9; pfam13426
665571004805	putative active site [active]
665571004806	heme pocket [chemical binding]; other site
665571004807	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
665571004808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571004809	Walker A motif; other site
665571004810	ATP binding site [chemical binding]; other site
665571004811	Walker B motif; other site
665571004812	arginine finger; other site
665571004813	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
665571004814	DNA-binding interface [nucleotide binding]; DNA binding site
665571004815	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
665571004816	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571004817	DNA binding residues [nucleotide binding]
665571004818	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
665571004819	High-affinity nickel-transport protein; Region: NicO; cl00964
665571004820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
665571004821	AAA domain; Region: AAA_23; pfam13476
665571004822	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
665571004823	Walker A/P-loop; other site
665571004824	ATP binding site [chemical binding]; other site
665571004825	Q-loop/lid; other site
665571004826	ABC transporter signature motif; other site
665571004827	Walker B; other site
665571004828	D-loop; other site
665571004829	H-loop/switch region; other site
665571004830	HEPN domain; Region: HEPN; pfam05168
665571004831	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
665571004832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571004833	Walker A/P-loop; other site
665571004834	ATP binding site [chemical binding]; other site
665571004835	Q-loop/lid; other site
665571004836	ABC transporter signature motif; other site
665571004837	Walker B; other site
665571004838	D-loop; other site
665571004839	H-loop/switch region; other site
665571004840	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
665571004841	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
665571004842	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
665571004843	sugar binding site [chemical binding]; other site
665571004844	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
665571004845	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_3; cd11575
665571004846	putative ligand binding site [chemical binding]; other site
665571004847	putative catalytic site [active]
665571004848	beta-phosphoglucomutase; Region: bPGM; TIGR01990
665571004849	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571004850	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
665571004851	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
665571004852	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
665571004853	maltose phosphorylase; Provisional; Region: PRK13807
665571004854	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
665571004855	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
665571004856	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571004857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004858	dimer interface [polypeptide binding]; other site
665571004859	conserved gate region; other site
665571004860	putative PBP binding loops; other site
665571004861	ABC-ATPase subunit interface; other site
665571004862	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571004863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571004864	dimer interface [polypeptide binding]; other site
665571004865	conserved gate region; other site
665571004866	putative PBP binding loops; other site
665571004867	ABC-ATPase subunit interface; other site
665571004868	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571004869	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
665571004870	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571004871	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571004872	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571004873	dimer interface [polypeptide binding]; other site
665571004874	putative CheW interface [polypeptide binding]; other site
665571004875	Transcriptional regulators [Transcription]; Region: PurR; COG1609
665571004876	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571004877	DNA binding site [nucleotide binding]
665571004878	domain linker motif; other site
665571004879	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
665571004880	dimerization interface [polypeptide binding]; other site
665571004881	ligand binding site [chemical binding]; other site
665571004882	LVIVD repeat; Region: LVIVD; pfam08309
665571004883	PQQ-like domain; Region: PQQ_2; pfam13360
665571004884	LVIVD repeat; Region: LVIVD; pfam08309
665571004885	LVIVD repeat; Region: LVIVD; pfam08309
665571004886	Uncharacterized conserved protein [Function unknown]; Region: COG5276
665571004887	LVIVD repeat; Region: LVIVD; pfam08309
665571004888	LVIVD repeat; Region: LVIVD; pfam08309
665571004889	LVIVD repeat; Region: LVIVD; pfam08309
665571004890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571004891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571004892	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
665571004893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
665571004894	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
665571004895	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
665571004896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571004897	S-adenosylmethionine binding site [chemical binding]; other site
665571004898	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571004899	MULE transposase domain; Region: MULE; pfam10551
665571004900	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
665571004901	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
665571004902	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
665571004903	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
665571004904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
665571004905	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571004906	active site
665571004907	NTP binding site [chemical binding]; other site
665571004908	metal binding triad [ion binding]; metal-binding site
665571004909	antibiotic binding site [chemical binding]; other site
665571004910	Uncharacterized conserved protein [Function unknown]; Region: COG2361
665571004911	MarC family integral membrane protein; Region: MarC; cl00919
665571004912	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571004913	active site
665571004914	NTP binding site [chemical binding]; other site
665571004915	metal binding triad [ion binding]; metal-binding site
665571004916	antibiotic binding site [chemical binding]; other site
665571004917	Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]; Region: COG2250
665571004918	Uncharacterized conserved protein [Function unknown]; Region: COG2006
665571004919	Domain of unknown function (DUF362); Region: DUF362; pfam04015
665571004920	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
665571004921	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004922	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
665571004923	4Fe-4S binding domain; Region: Fer4; pfam00037
665571004924	LicD family; Region: LicD; pfam04991
665571004925	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
665571004926	active site
665571004927	metal-binding site
665571004928	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
665571004929	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571004930	catalytic residue [active]
665571004931	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
665571004932	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
665571004933	PYR/PP interface [polypeptide binding]; other site
665571004934	dimer interface [polypeptide binding]; other site
665571004935	TPP binding site [chemical binding]; other site
665571004936	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
665571004937	TPP-binding site [chemical binding]; other site
665571004938	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
665571004939	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
665571004940	tetramer interface [polypeptide binding]; other site
665571004941	active site
665571004942	Mg2+/Mn2+ binding site [ion binding]; other site
665571004943	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
665571004944	active site
665571004945	metal-binding site
665571004946	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
665571004947	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
665571004948	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
665571004949	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
665571004950	active site
665571004951	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
665571004952	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
665571004953	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
665571004954	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004955	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004956	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
665571004957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004958	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
665571004959	putative ADP-binding pocket [chemical binding]; other site
665571004960	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
665571004961	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004962	putative ADP-binding pocket [chemical binding]; other site
665571004963	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
665571004964	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
665571004965	metal-binding site
665571004966	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004967	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
665571004968	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
665571004969	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
665571004970	NADP binding site [chemical binding]; other site
665571004971	active site
665571004972	putative substrate binding site [chemical binding]; other site
665571004973	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
665571004974	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
665571004975	NADP-binding site; other site
665571004976	homotetramer interface [polypeptide binding]; other site
665571004977	substrate binding site [chemical binding]; other site
665571004978	homodimer interface [polypeptide binding]; other site
665571004979	active site
665571004980	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571004981	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571004982	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
665571004983	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
665571004984	Mg++ binding site [ion binding]; other site
665571004985	putative catalytic motif [active]
665571004986	substrate binding site [chemical binding]; other site
665571004987	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571004988	active site
665571004989	NTP binding site [chemical binding]; other site
665571004990	metal binding triad [ion binding]; metal-binding site
665571004991	antibiotic binding site [chemical binding]; other site
665571004992	Poly A polymerase head domain; Region: PolyA_pol; pfam01743
665571004993	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
665571004994	histidyl-tRNA synthetase; Region: hisS; TIGR00442
665571004995	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
665571004996	dimer interface [polypeptide binding]; other site
665571004997	motif 1; other site
665571004998	active site
665571004999	motif 2; other site
665571005000	motif 3; other site
665571005001	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
665571005002	anticodon binding site; other site
665571005003	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
665571005004	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
665571005005	ATP binding site [chemical binding]; other site
665571005006	putative Mg++ binding site [ion binding]; other site
665571005007	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
665571005008	nucleotide binding region [chemical binding]; other site
665571005009	ATP-binding site [chemical binding]; other site
665571005010	Helicase associated domain (HA2); Region: HA2; pfam04408
665571005011	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
665571005012	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
665571005013	active site
665571005014	dimer interface [polypeptide binding]; other site
665571005015	metal binding site [ion binding]; metal-binding site
665571005016	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
665571005017	Glyco_18 domain; Region: Glyco_18; smart00636
665571005018	active site
665571005019	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
665571005020	aromatic chitin/cellulose binding site residues [chemical binding]; other site
665571005021	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
665571005022	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
665571005023	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
665571005024	SLBB domain; Region: SLBB; pfam10531
665571005025	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
665571005026	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571005027	dimerization interface [polypeptide binding]; other site
665571005028	putative DNA binding site [nucleotide binding]; other site
665571005029	putative Zn2+ binding site [ion binding]; other site
665571005030	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
665571005031	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
665571005032	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571005033	catalytic residue [active]
665571005034	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
665571005035	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
665571005036	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
665571005037	Ligand Binding Site [chemical binding]; other site
665571005038	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
665571005039	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
665571005040	substrate binding site [chemical binding]; other site
665571005041	glutamase interaction surface [polypeptide binding]; other site
665571005042	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
665571005043	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
665571005044	putative active site [active]
665571005045	oxyanion strand; other site
665571005046	catalytic triad [active]
665571005047	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
665571005048	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
665571005049	HIGH motif; other site
665571005050	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
665571005051	active site
665571005052	KMSKS motif; other site
665571005053	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
665571005054	tRNA binding surface [nucleotide binding]; other site
665571005055	anticodon binding site; other site
665571005056	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
665571005057	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
665571005058	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
665571005059	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
665571005060	putative active site [active]
665571005061	catalytic site [active]
665571005062	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
665571005063	putative ligand binding site [chemical binding]; other site
665571005064	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
665571005065	glycogen binding site [chemical binding]; other site
665571005066	alpha-amylase; Region: PLN02361
665571005067	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
665571005068	active site
665571005069	Ca binding site [ion binding]; other site
665571005070	catalytic site [active]
665571005071	Alpha-amylase C-terminal beta-sheet domain; Region: Alpha-amyl_C2; pfam07821
665571005072	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571005073	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571005074	dimer interface [polypeptide binding]; other site
665571005075	putative CheW interface [polypeptide binding]; other site
665571005076	WGR domain; Region: WGR; cl01581
665571005077	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
665571005078	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
665571005079	active site
665571005080	Zn binding site [ion binding]; other site
665571005081	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
665571005082	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
665571005083	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
665571005084	active site
665571005085	dimer interface [polypeptide binding]; other site
665571005086	motif 1; other site
665571005087	motif 2; other site
665571005088	motif 3; other site
665571005089	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
665571005090	anticodon binding site; other site
665571005091	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
665571005092	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
665571005093	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
665571005094	hypothetical protein; Reviewed; Region: PRK09588
665571005095	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
665571005096	putative ligand binding pocket/active site [active]
665571005097	putative metal binding site [ion binding]; other site
665571005098	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
665571005099	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
665571005100	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
665571005101	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571005102	Walker A/P-loop; other site
665571005103	ATP binding site [chemical binding]; other site
665571005104	Q-loop/lid; other site
665571005105	ABC transporter signature motif; other site
665571005106	Walker B; other site
665571005107	D-loop; other site
665571005108	H-loop/switch region; other site
665571005109	ribonuclease Z; Region: RNase_Z; TIGR02651
665571005110	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
665571005111	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
665571005112	inhibitor-cofactor binding pocket; inhibition site
665571005113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571005114	catalytic residue [active]
665571005115	Delta-aminolevulinic acid dehydratase; Region: ALAD; pfam00490
665571005116	dimer interface [polypeptide binding]; other site
665571005117	active site
665571005118	Schiff base residues; other site
665571005119	porphobilinogen deaminase; Provisional; Region: PRK01066
665571005120	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
665571005121	domain interfaces; other site
665571005122	active site
665571005123	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
665571005124	active site
665571005125	SAM binding site [chemical binding]; other site
665571005126	homodimer interface [polypeptide binding]; other site
665571005127	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
665571005128	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
665571005129	active site
665571005130	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
665571005131	NAD(P) binding pocket [chemical binding]; other site
665571005132	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
665571005133	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
665571005134	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
665571005135	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
665571005136	G1 box; other site
665571005137	GTP/Mg2+ binding site [chemical binding]; other site
665571005138	G2 box; other site
665571005139	Switch I region; other site
665571005140	G3 box; other site
665571005141	Switch II region; other site
665571005142	G4 box; other site
665571005143	G5 box; other site
665571005144	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
665571005145	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
665571005146	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
665571005147	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
665571005148	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
665571005149	Active Sites [active]
665571005150	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
665571005151	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
665571005152	Active Sites [active]
665571005153	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
665571005154	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
665571005155	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
665571005156	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
665571005157	HEPN domain; Region: HEPN; cl00824
665571005158	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
665571005159	CPxP  motif; other site
665571005160	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
665571005161	MPN+ (JAMM) motif; other site
665571005162	Zinc-binding site [ion binding]; other site
665571005163	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
665571005164	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
665571005165	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
665571005166	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
665571005167	ATP binding site [chemical binding]; other site
665571005168	substrate interface [chemical binding]; other site
665571005169	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
665571005170	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
665571005171	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
665571005172	catalytic residue [active]
665571005173	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
665571005174	thiS-thiF/thiG interaction site; other site
665571005175	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
665571005176	non-specific DNA interactions [nucleotide binding]; other site
665571005177	DNA binding site [nucleotide binding]
665571005178	sequence specific DNA binding site [nucleotide binding]; other site
665571005179	putative cAMP binding site [chemical binding]; other site
665571005180	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
665571005181	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
665571005182	nucleotide binding site [chemical binding]; other site
665571005183	xylose isomerase; Provisional; Region: PRK05474
665571005184	xylose isomerase; Region: xylose_isom_A; TIGR02630
665571005185	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
665571005186	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
665571005187	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
665571005188	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
665571005189	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
665571005190	HflK protein; Region: hflK; TIGR01933
665571005191	HflC protein; Region: hflC; TIGR01932
665571005192	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
665571005193	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571005194	I-site; other site
665571005195	metal binding site [ion binding]; metal-binding site
665571005196	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
665571005197	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
665571005198	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
665571005199	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
665571005200	Putative Fe-S cluster; Region: FeS; cl17515
665571005201	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571005202	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571005203	dimer interface [polypeptide binding]; other site
665571005204	putative CheW interface [polypeptide binding]; other site
665571005205	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
665571005206	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
665571005207	active site
665571005208	catalytic tetrad [active]
665571005209	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
665571005210	Recombination protein O N terminal; Region: RecO_N; pfam11967
665571005211	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
665571005212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571005213	Walker A motif; other site
665571005214	ATP binding site [chemical binding]; other site
665571005215	Walker B motif; other site
665571005216	arginine finger; other site
665571005217	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
665571005218	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
665571005219	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
665571005220	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
665571005221	Peptidase family U32; Region: Peptidase_U32; pfam01136
665571005222	Domain of unknown function (DUF303); Region: DUF303; pfam03629
665571005223	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
665571005224	Domain of unknown function (DUF303); Region: DUF303; pfam03629
665571005225	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
665571005226	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
665571005227	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
665571005228	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
665571005229	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
665571005230	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
665571005231	dimerization interface [polypeptide binding]; other site
665571005232	Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059
665571005233	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
665571005234	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
665571005235	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
665571005236	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
665571005237	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
665571005238	dimer interface [polypeptide binding]; other site
665571005239	substrate binding site [chemical binding]; other site
665571005240	metal binding site [ion binding]; metal-binding site
665571005241	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
665571005242	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
665571005243	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571005244	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571005245	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
665571005246	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571005247	PAS domain; Region: PAS_9; pfam13426
665571005248	putative active site [active]
665571005249	heme pocket [chemical binding]; other site
665571005250	PAS fold; Region: PAS_4; pfam08448
665571005251	PAS domain; Region: PAS; smart00091
665571005252	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
665571005253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571005254	dimer interface [polypeptide binding]; other site
665571005255	phosphorylation site [posttranslational modification]
665571005256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571005257	ATP binding site [chemical binding]; other site
665571005258	Mg2+ binding site [ion binding]; other site
665571005259	G-X-G motif; other site
665571005260	Response regulator receiver domain; Region: Response_reg; pfam00072
665571005261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571005262	active site
665571005263	phosphorylation site [posttranslational modification]
665571005264	intermolecular recognition site; other site
665571005265	dimerization interface [polypeptide binding]; other site
665571005266	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
665571005267	putative binding surface; other site
665571005268	active site
665571005269	3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; pfam02544
665571005270	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
665571005271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571005272	NAD(P) binding site [chemical binding]; other site
665571005273	active site
665571005274	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
665571005275	putative active site; other site
665571005276	putative metal binding residues [ion binding]; other site
665571005277	signature motif; other site
665571005278	putative triphosphate binding site [ion binding]; other site
665571005279	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
665571005280	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
665571005281	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
665571005282	putative active site [active]
665571005283	putative substrate binding site [chemical binding]; other site
665571005284	putative cosubstrate binding site; other site
665571005285	catalytic site [active]
665571005286	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
665571005287	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
665571005288	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
665571005289	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571005290	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
665571005291	Domain of unknown function (DUF4165); Region: DUF4165; pfam13752
665571005292	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
665571005293	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
665571005294	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
665571005295	ligand binding site [chemical binding]; other site
665571005296	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
665571005297	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571005298	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
665571005299	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
665571005300	dimer interface [polypeptide binding]; other site
665571005301	PYR/PP interface [polypeptide binding]; other site
665571005302	TPP binding site [chemical binding]; other site
665571005303	substrate binding site [chemical binding]; other site
665571005304	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
665571005305	Domain of unknown function; Region: EKR; pfam10371
665571005306	4Fe-4S binding domain; Region: Fer4_6; pfam12837
665571005307	4Fe-4S binding domain; Region: Fer4; pfam00037
665571005308	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
665571005309	TPP-binding site [chemical binding]; other site
665571005310	dimer interface [polypeptide binding]; other site
665571005311	Flavin Reductases; Region: FlaRed; cl00801
665571005312	PilZ domain; Region: PilZ; pfam07238
665571005313	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
665571005314	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
665571005315	substrate binding site [chemical binding]; other site
665571005316	hexamer interface [polypeptide binding]; other site
665571005317	metal binding site [ion binding]; metal-binding site
665571005318	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
665571005319	tetramer (dimer of dimers) interface [polypeptide binding]; other site
665571005320	active site
665571005321	dimer interface [polypeptide binding]; other site
665571005322	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
665571005323	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
665571005324	THF binding site; other site
665571005325	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
665571005326	substrate binding site [chemical binding]; other site
665571005327	THF binding site; other site
665571005328	zinc-binding site [ion binding]; other site
665571005329	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
665571005330	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
665571005331	putative Mg++ binding site [ion binding]; other site
665571005332	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
665571005333	RNA binding site [nucleotide binding]; other site
665571005334	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
665571005335	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
665571005336	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
665571005337	rRNA binding site [nucleotide binding]; other site
665571005338	predicted 30S ribosome binding site; other site
665571005339	Smr domain; Region: Smr; pfam01713
665571005340	Oxygen tolerance; Region: BatD; pfam13584
665571005341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571005342	binding surface
665571005343	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571005344	TPR motif; other site
665571005345	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571005346	binding surface
665571005347	TPR motif; other site
665571005348	TPR repeat; Region: TPR_11; pfam13414
665571005349	von Willebrand factor type A domain; Region: VWA_2; pfam13519
665571005350	metal ion-dependent adhesion site (MIDAS); other site
665571005351	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
665571005352	metal ion-dependent adhesion site (MIDAS); other site
665571005353	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
665571005354	Protein of unknown function DUF58; Region: DUF58; pfam01882
665571005355	MoxR-like ATPases [General function prediction only]; Region: COG0714
665571005356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571005357	Walker A motif; other site
665571005358	ATP binding site [chemical binding]; other site
665571005359	Walker B motif; other site
665571005360	arginine finger; other site
665571005361	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
665571005362	heterotetramer interface [polypeptide binding]; other site
665571005363	active site pocket [active]
665571005364	cleavage site
665571005365	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
665571005366	histidinol-phosphatase; Provisional; Region: PRK07328
665571005367	active site
665571005368	dimer interface [polypeptide binding]; other site
665571005369	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
665571005370	catalytic core [active]
665571005371	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
665571005372	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
665571005373	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
665571005374	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
665571005375	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571005376	Walker A/P-loop; other site
665571005377	ATP binding site [chemical binding]; other site
665571005378	Q-loop/lid; other site
665571005379	ABC transporter signature motif; other site
665571005380	Walker B; other site
665571005381	D-loop; other site
665571005382	H-loop/switch region; other site
665571005383	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
665571005384	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
665571005385	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
665571005386	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
665571005387	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
665571005388	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
665571005389	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571005390	active site
665571005391	NTP binding site [chemical binding]; other site
665571005392	metal binding triad [ion binding]; metal-binding site
665571005393	HEPN domain; Region: HEPN; pfam05168
665571005394	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
665571005395	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
665571005396	MutS domain III; Region: MutS_III; pfam05192
665571005397	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
665571005398	Walker A/P-loop; other site
665571005399	ATP binding site [chemical binding]; other site
665571005400	Q-loop/lid; other site
665571005401	ABC transporter signature motif; other site
665571005402	Walker B; other site
665571005403	D-loop; other site
665571005404	H-loop/switch region; other site
665571005405	Smr domain; Region: Smr; pfam01713
665571005406	GTPase RsgA; Reviewed; Region: PRK00098
665571005407	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
665571005408	RNA binding site [nucleotide binding]; other site
665571005409	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
665571005410	GTPase/Zn-binding domain interface [polypeptide binding]; other site
665571005411	GTP/Mg2+ binding site [chemical binding]; other site
665571005412	G4 box; other site
665571005413	G5 box; other site
665571005414	G1 box; other site
665571005415	Switch I region; other site
665571005416	G2 box; other site
665571005417	G3 box; other site
665571005418	Switch II region; other site
665571005419	glutamate racemase; Provisional; Region: PRK00865
665571005420	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
665571005421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
665571005422	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
665571005423	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
665571005424	RNA binding surface [nucleotide binding]; other site
665571005425	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
665571005426	active site
665571005427	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
665571005428	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
665571005429	catalytic residue [active]
665571005430	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
665571005431	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
665571005432	active site
665571005433	multimer interface [polypeptide binding]; other site
665571005434	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
665571005435	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
665571005436	predicted active site [active]
665571005437	catalytic triad [active]
665571005438	LytB protein; Region: LYTB; cl00507
665571005439	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
665571005440	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
665571005441	substrate binding pocket [chemical binding]; other site
665571005442	substrate-Mg2+ binding site; other site
665571005443	aspartate-rich region 1; other site
665571005444	aspartate-rich region 2; other site
665571005445	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
665571005446	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
665571005447	Protein of unknown function (DUF401); Region: DUF401; cl00830
665571005448	Protein of unknown function (DUF401); Region: DUF401; cl00830
665571005449	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
665571005450	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
665571005451	PYR/PP interface [polypeptide binding]; other site
665571005452	dimer interface [polypeptide binding]; other site
665571005453	TPP binding site [chemical binding]; other site
665571005454	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
665571005455	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
665571005456	TPP-binding site [chemical binding]; other site
665571005457	dimer interface [polypeptide binding]; other site
665571005458	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
665571005459	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
665571005460	putative valine binding site [chemical binding]; other site
665571005461	dimer interface [polypeptide binding]; other site
665571005462	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
665571005463	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571005464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571005465	active site
665571005466	phosphorylation site [posttranslational modification]
665571005467	intermolecular recognition site; other site
665571005468	dimerization interface [polypeptide binding]; other site
665571005469	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
665571005470	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
665571005471	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
665571005472	putative CheA interaction surface; other site
665571005473	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
665571005474	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
665571005475	putative binding surface; other site
665571005476	active site
665571005477	P2 response regulator binding domain; Region: P2; pfam07194
665571005478	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
665571005479	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
665571005480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571005481	ATP binding site [chemical binding]; other site
665571005482	Mg2+ binding site [ion binding]; other site
665571005483	G-X-G motif; other site
665571005484	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
665571005485	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
665571005486	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
665571005487	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
665571005488	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
665571005489	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
665571005490	Walker A/P-loop; other site
665571005491	ATP binding site [chemical binding]; other site
665571005492	Q-loop/lid; other site
665571005493	ABC transporter signature motif; other site
665571005494	Walker B; other site
665571005495	D-loop; other site
665571005496	H-loop/switch region; other site
665571005497	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
665571005498	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
665571005499	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
665571005500	Walker A/P-loop; other site
665571005501	ATP binding site [chemical binding]; other site
665571005502	Q-loop/lid; other site
665571005503	ABC transporter signature motif; other site
665571005504	Walker B; other site
665571005505	D-loop; other site
665571005506	H-loop/switch region; other site
665571005507	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
665571005508	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
665571005509	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
665571005510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571005511	dimer interface [polypeptide binding]; other site
665571005512	conserved gate region; other site
665571005513	putative PBP binding loops; other site
665571005514	ABC-ATPase subunit interface; other site
665571005515	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
665571005516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571005517	dimer interface [polypeptide binding]; other site
665571005518	conserved gate region; other site
665571005519	putative PBP binding loops; other site
665571005520	ABC-ATPase subunit interface; other site
665571005521	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
665571005522	substrate binding site [chemical binding]; other site
665571005523	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
665571005524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571005525	Transcriptional regulators [Transcription]; Region: MarR; COG1846
665571005526	putative DNA binding site [nucleotide binding]; other site
665571005527	putative Zn2+ binding site [ion binding]; other site
665571005528	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
665571005529	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
665571005530	N-acetylglutamate synthase; Validated; Region: PRK05279
665571005531	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
665571005532	nucleotide binding site [chemical binding]; other site
665571005533	substrate binding site [chemical binding]; other site
665571005534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
665571005535	Coenzyme A binding pocket [chemical binding]; other site
665571005536	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
665571005537	active site
665571005538	multimer interface [polypeptide binding]; other site
665571005539	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
665571005540	active site
665571005541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571005542	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571005543	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
665571005544	Domain of unknown function (DUF377); Region: DUF377; pfam04041
665571005545	active site
665571005546	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
665571005547	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
665571005548	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
665571005549	protein binding site [polypeptide binding]; other site
665571005550	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
665571005551	protein binding site [polypeptide binding]; other site
665571005552	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
665571005553	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
665571005554	putative dimer interface [polypeptide binding]; other site
665571005555	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
665571005556	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
665571005557	putative dimer interface [polypeptide binding]; other site
665571005558	oxidoreductase; Validated; Region: PRK05717
665571005559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571005560	NAD(P) binding site [chemical binding]; other site
665571005561	active site
665571005562	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
665571005563	putative nucleotide binding site [chemical binding]; other site
665571005564	putative metal binding site [ion binding]; other site
665571005565	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
665571005566	dinuclear metal binding motif [ion binding]; other site
665571005567	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
665571005568	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
665571005569	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
665571005570	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
665571005571	cyclase homology domain; Region: CHD; cd07302
665571005572	nucleotidyl binding site; other site
665571005573	metal binding site [ion binding]; metal-binding site
665571005574	dimer interface [polypeptide binding]; other site
665571005575	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
665571005576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571005577	motif II; other site
665571005578	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
665571005579	active site
665571005580	NTP binding site [chemical binding]; other site
665571005581	metal binding triad [ion binding]; metal-binding site
665571005582	antibiotic binding site [chemical binding]; other site
665571005583	HEPN domain; Region: HEPN; pfam05168
665571005584	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
665571005585	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
665571005586	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
665571005587	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
665571005588	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
665571005589	diphosphate--fructose-6-phosphate 1-phosphotransferase; Region: PFKA_PPi; TIGR02477
665571005590	active site
665571005591	ADP/pyrophosphate binding site [chemical binding]; other site
665571005592	dimerization interface [polypeptide binding]; other site
665571005593	allosteric effector site; other site
665571005594	fructose-1,6-bisphosphate binding site; other site
665571005595	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
665571005596	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
665571005597	substrate binding site [chemical binding]; other site
665571005598	ATP binding site [chemical binding]; other site
665571005599	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
665571005600	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
665571005601	active site
665571005602	NAD binding site [chemical binding]; other site
665571005603	metal binding site [ion binding]; metal-binding site
665571005604	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
665571005605	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
665571005606	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
665571005607	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
665571005608	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
665571005609	active site
665571005610	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
665571005611	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
665571005612	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
665571005613	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
665571005614	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
665571005615	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
665571005616	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
665571005617	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
665571005618	FMN binding site [chemical binding]; other site
665571005619	dimer interface [polypeptide binding]; other site
665571005620	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
665571005621	active site
665571005622	DNA polymerase IV; Validated; Region: PRK02406
665571005623	DNA binding site [nucleotide binding]
665571005624	Membrane transport protein; Region: Mem_trans; cl09117
665571005625	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571005626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571005627	active site
665571005628	phosphorylation site [posttranslational modification]
665571005629	intermolecular recognition site; other site
665571005630	dimerization interface [polypeptide binding]; other site
665571005631	PAS domain S-box; Region: sensory_box; TIGR00229
665571005632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571005633	putative active site [active]
665571005634	heme pocket [chemical binding]; other site
665571005635	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571005636	Histidine kinase; Region: HisKA_2; pfam07568
665571005637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571005638	ATP binding site [chemical binding]; other site
665571005639	Mg2+ binding site [ion binding]; other site
665571005640	G-X-G motif; other site
665571005641	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
665571005642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
665571005643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571005644	homodimer interface [polypeptide binding]; other site
665571005645	catalytic residue [active]
665571005646	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
665571005647	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
665571005648	putative acyl-acceptor binding pocket; other site
665571005649	Predicted integral membrane protein [Function unknown]; Region: COG5542
665571005650	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
665571005651	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
665571005652	Ligand binding site; other site
665571005653	Putative Catalytic site; other site
665571005654	DXD motif; other site
665571005655	Predicted membrane protein [Function unknown]; Region: COG2246
665571005656	GtrA-like protein; Region: GtrA; pfam04138
665571005657	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
665571005658	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
665571005659	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
665571005660	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
665571005661	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
665571005662	phosphate binding site [ion binding]; other site
665571005663	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571005664	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
665571005665	TM-ABC transporter signature motif; other site
665571005666	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571005667	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
665571005668	TM-ABC transporter signature motif; other site
665571005669	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
665571005670	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
665571005671	Walker A/P-loop; other site
665571005672	ATP binding site [chemical binding]; other site
665571005673	Q-loop/lid; other site
665571005674	ABC transporter signature motif; other site
665571005675	Walker B; other site
665571005676	D-loop; other site
665571005677	H-loop/switch region; other site
665571005678	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
665571005679	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
665571005680	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
665571005681	ligand binding site [chemical binding]; other site
665571005682	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
665571005683	intersubunit interface [polypeptide binding]; other site
665571005684	active site
665571005685	catalytic residue [active]
665571005686	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
665571005687	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
665571005688	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
665571005689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
665571005690	TPR repeat; Region: TPR_11; pfam13414
665571005691	binding surface
665571005692	TPR motif; other site
665571005693	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
665571005694	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
665571005695	NADP binding site [chemical binding]; other site
665571005696	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
665571005697	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
665571005698	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
665571005699	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
665571005700	hydroxyglutarate oxidase; Provisional; Region: PRK11728
665571005701	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
665571005702	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
665571005703	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
665571005704	Bacitracin resistance protein BacA; Region: BacA; cl00858
665571005705	Bacitracin resistance protein BacA; Region: BacA; cl00858
665571005706	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
665571005707	N-acetyl-D-glucosamine binding site [chemical binding]; other site
665571005708	catalytic residue [active]
665571005709	Predicted amidohydrolase [General function prediction only]; Region: COG0388
665571005710	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
665571005711	active site
665571005712	catalytic triad [active]
665571005713	dimer interface [polypeptide binding]; other site
665571005714	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
665571005715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571005716	dimer interface [polypeptide binding]; other site
665571005717	conserved gate region; other site
665571005718	putative PBP binding loops; other site
665571005719	ABC-ATPase subunit interface; other site
665571005720	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
665571005721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571005722	Q-loop/lid; other site
665571005723	ABC transporter signature motif; other site
665571005724	Walker B; other site
665571005725	D-loop; other site
665571005726	H-loop/switch region; other site
665571005727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571005728	conserved gate region; other site
665571005729	ABC-ATPase subunit interface; other site
665571005730	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
665571005731	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
665571005732	G1 box; other site
665571005733	GTP/Mg2+ binding site [chemical binding]; other site
665571005734	Switch I region; other site
665571005735	G2 box; other site
665571005736	Switch II region; other site
665571005737	G3 box; other site
665571005738	G4 box; other site
665571005739	G5 box; other site
665571005740	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
665571005741	tetramer interface [polypeptide binding]; other site
665571005742	biotin synthase; Provisional; Region: PRK07094
665571005743	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571005744	FeS/SAM binding site; other site
665571005745	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
665571005746	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
665571005747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571005748	FeS/SAM binding site; other site
665571005749	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
665571005750	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
665571005751	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
665571005752	active site
665571005753	metal binding site [ion binding]; metal-binding site
665571005754	Uncharacterized conserved protein [Function unknown]; Region: COG0432
665571005755	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
665571005756	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
665571005757	nucleotide binding site [chemical binding]; other site
665571005758	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
665571005759	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
665571005760	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
665571005761	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
665571005762	active site
665571005763	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
665571005764	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
665571005765	catalytic domain interface [polypeptide binding]; other site
665571005766	homodimer interface [polypeptide binding]; other site
665571005767	putative active site [active]
665571005768	Cyclophilin-like; Region: Cyclophil_like; cl17583
665571005769	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
665571005770	Peptidase family M28; Region: Peptidase_M28; pfam04389
665571005771	metal binding site [ion binding]; metal-binding site
665571005772	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571005773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571005774	Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; Region: Bcl-2_like; cl02575
665571005775	BH3-homology region binding site; other site
665571005776	BH1; other site
665571005777	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
665571005778	classical (c) SDRs; Region: SDR_c; cd05233
665571005779	NAD(P) binding site [chemical binding]; other site
665571005780	active site
665571005781	short chain dehydrogenase; Provisional; Region: PRK06197
665571005782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571005783	NAD(P) binding site [chemical binding]; other site
665571005784	active site
665571005785	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
665571005786	FMN-binding domain; Region: FMN_bind; pfam04205
665571005787	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571005788	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
665571005789	Walker A/P-loop; other site
665571005790	ATP binding site [chemical binding]; other site
665571005791	Q-loop/lid; other site
665571005792	ABC transporter signature motif; other site
665571005793	Walker B; other site
665571005794	D-loop; other site
665571005795	H-loop/switch region; other site
665571005796	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571005797	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571005798	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
665571005799	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571005800	FtsX-like permease family; Region: FtsX; pfam02687
665571005801	Predicted membrane protein [Function unknown]; Region: COG4393
665571005802	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
665571005803	Fe2+ transport protein; Region: Iron_transport; pfam10634
665571005804	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
665571005805	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
665571005806	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
665571005807	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
665571005808	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
665571005809	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
665571005810	active site
665571005811	HIGH motif; other site
665571005812	nucleotide binding site [chemical binding]; other site
665571005813	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
665571005814	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
665571005815	active site
665571005816	KMSKS motif; other site
665571005817	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
665571005818	tRNA binding surface [nucleotide binding]; other site
665571005819	anticodon binding site; other site
665571005820	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
665571005821	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
665571005822	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
665571005823	ligand binding site [chemical binding]; other site
665571005824	flexible hinge region; other site
665571005825	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
665571005826	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
665571005827	ligand binding site [chemical binding]; other site
665571005828	flexible hinge region; other site
665571005829	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
665571005830	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
665571005831	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
665571005832	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
665571005833	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
665571005834	DNA binding residues [nucleotide binding]
665571005835	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536
665571005836	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
665571005837	active site
665571005838	HIGH motif; other site
665571005839	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
665571005840	KMSKS motif; other site
665571005841	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
665571005842	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
665571005843	PEGA domain; Region: PEGA; pfam08308
665571005844	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
665571005845	propionate/acetate kinase; Provisional; Region: PRK12379
665571005846	DJ-1 family protein; Region: not_thiJ; TIGR01383
665571005847	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
665571005848	conserved cys residue [active]
665571005849	primosome assembly protein PriA; Validated; Region: PRK05580
665571005850	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
665571005851	ATP binding site [chemical binding]; other site
665571005852	putative Mg++ binding site [ion binding]; other site
665571005853	helicase superfamily c-terminal domain; Region: HELICc; smart00490
665571005854	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
665571005855	Fe-S cluster binding site [ion binding]; other site
665571005856	active site
665571005857	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
665571005858	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
665571005859	dimerization interface 3.5A [polypeptide binding]; other site
665571005860	active site
665571005861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
665571005862	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
665571005863	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
665571005864	YbbR-like protein; Region: YbbR; pfam07949
665571005865	Uncharacterized conserved protein [Function unknown]; Region: COG1624
665571005866	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
665571005867	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
665571005868	dihydropteroate synthase; Region: DHPS; TIGR01496
665571005869	substrate binding pocket [chemical binding]; other site
665571005870	dimer interface [polypeptide binding]; other site
665571005871	inhibitor binding site; inhibition site
665571005872	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
665571005873	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
665571005874	TPP-binding site; other site
665571005875	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
665571005876	PYR/PP interface [polypeptide binding]; other site
665571005877	dimer interface [polypeptide binding]; other site
665571005878	TPP binding site [chemical binding]; other site
665571005879	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
665571005880	antiporter inner membrane protein; Provisional; Region: PRK11670
665571005881	Domain of unknown function DUF59; Region: DUF59; pfam01883
665571005882	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
665571005883	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
665571005884	Mechanosensitive ion channel; Region: MS_channel; pfam00924
665571005885	Protein of unknown function (DUF432); Region: DUF432; cl01027
665571005886	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
665571005887	isocitrate dehydrogenase; Validated; Region: PRK07362
665571005888	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
665571005889	N-acetyl-D-glucosamine binding site [chemical binding]; other site
665571005890	catalytic residue [active]
665571005891	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571005892	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
665571005893	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
665571005894	diaminopimelate aminotransferase; Provisional; Region: PRK13983
665571005895	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
665571005896	metal binding site [ion binding]; metal-binding site
665571005897	Uncharacterized conserved protein [Function unknown]; Region: COG1739
665571005898	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
665571005899	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
665571005900	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
665571005901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
665571005902	DNA-binding site [nucleotide binding]; DNA binding site
665571005903	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
665571005904	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
665571005905	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
665571005906	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
665571005907	inhibitor binding site; inhibition site
665571005908	active site
665571005909	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571005910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571005911	dimer interface [polypeptide binding]; other site
665571005912	conserved gate region; other site
665571005913	putative PBP binding loops; other site
665571005914	ABC-ATPase subunit interface; other site
665571005915	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571005916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571005917	ABC-ATPase subunit interface; other site
665571005918	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
665571005919	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
665571005920	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
665571005921	active site
665571005922	dimerization interface [polypeptide binding]; other site
665571005923	oligoendopeptidase F; Region: pepF; TIGR00181
665571005924	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
665571005925	active site
665571005926	Zn binding site [ion binding]; other site
665571005927	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
665571005928	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
665571005929	putative active site [active]
665571005930	catalytic triad [active]
665571005931	putative dimer interface [polypeptide binding]; other site
665571005932	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
665571005933	IHF dimer interface [polypeptide binding]; other site
665571005934	IHF - DNA interface [nucleotide binding]; other site
665571005935	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
665571005936	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
665571005937	Protein of unknown function (DUF327); Region: DUF327; pfam03885
665571005938	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
665571005939	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
665571005940	Peptidase family M23; Region: Peptidase_M23; pfam01551
665571005941	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
665571005942	active site
665571005943	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
665571005944	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
665571005945	FMN binding site [chemical binding]; other site
665571005946	active site
665571005947	catalytic residues [active]
665571005948	substrate binding site [chemical binding]; other site
665571005949	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
665571005950	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
665571005951	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
665571005952	HSP70 interaction site [polypeptide binding]; other site
665571005953	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
665571005954	substrate binding site [polypeptide binding]; other site
665571005955	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
665571005956	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
665571005957	Zn binding sites [ion binding]; other site
665571005958	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
665571005959	dimer interface [polypeptide binding]; other site
665571005960	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
665571005961	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
665571005962	nucleotide binding site [chemical binding]; other site
665571005963	NEF interaction site [polypeptide binding]; other site
665571005964	SBD interface [polypeptide binding]; other site
665571005965	GrpE; Region: GrpE; pfam01025
665571005966	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
665571005967	dimer interface [polypeptide binding]; other site
665571005968	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
665571005969	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
665571005970	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
665571005971	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
665571005972	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
665571005973	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571005974	motif II; other site
665571005975	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
665571005976	AIR carboxylase; Region: AIRC; smart01001
665571005977	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
665571005978	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
665571005979	Ligand Binding Site [chemical binding]; other site
665571005980	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
665571005981	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
665571005982	cyclase homology domain; Region: CHD; cd07302
665571005983	nucleotidyl binding site; other site
665571005984	metal binding site [ion binding]; metal-binding site
665571005985	dimer interface [polypeptide binding]; other site
665571005986	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
665571005987	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
665571005988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571005989	catalytic residue [active]
665571005990	Trp repressor protein; Region: Trp_repressor; cl17266
665571005991	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
665571005992	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
665571005993	active site
665571005994	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
665571005995	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
665571005996	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
665571005997	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
665571005998	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571005999	Walker A/P-loop; other site
665571006000	ATP binding site [chemical binding]; other site
665571006001	Q-loop/lid; other site
665571006002	ABC transporter signature motif; other site
665571006003	Walker B; other site
665571006004	D-loop; other site
665571006005	H-loop/switch region; other site
665571006006	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571006007	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571006008	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
665571006009	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
665571006010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
665571006011	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
665571006012	Ferritin-like domain; Region: Ferritin; pfam00210
665571006013	dimerization interface [polypeptide binding]; other site
665571006014	DPS ferroxidase diiron center [ion binding]; other site
665571006015	ion pore; other site
665571006016	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
665571006017	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
665571006018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571006019	dimer interface [polypeptide binding]; other site
665571006020	conserved gate region; other site
665571006021	putative PBP binding loops; other site
665571006022	ABC-ATPase subunit interface; other site
665571006023	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
665571006024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571006025	dimer interface [polypeptide binding]; other site
665571006026	conserved gate region; other site
665571006027	ABC-ATPase subunit interface; other site
665571006028	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
665571006029	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
665571006030	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
665571006031	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
665571006032	ligand binding site [chemical binding]; other site
665571006033	metal binding site [ion binding]; metal-binding site
665571006034	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
665571006035	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
665571006036	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
665571006037	Prephenate dehydratase; Region: PDT; pfam00800
665571006038	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
665571006039	putative L-Phe binding site [chemical binding]; other site
665571006040	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
665571006041	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
665571006042	N-acetyl-D-glucosamine binding site [chemical binding]; other site
665571006043	catalytic residue [active]
665571006044	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
665571006045	Response regulator receiver domain; Region: Response_reg; pfam00072
665571006046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006047	active site
665571006048	phosphorylation site [posttranslational modification]
665571006049	intermolecular recognition site; other site
665571006050	dimerization interface [polypeptide binding]; other site
665571006051	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
665571006052	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
665571006053	peptide binding site [polypeptide binding]; other site
665571006054	Uncharacterized conserved protein [Function unknown]; Region: COG0398
665571006055	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
665571006056	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
665571006057	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
665571006058	substrate binding site; other site
665571006059	dimer interface; other site
665571006060	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
665571006061	homotrimer interaction site [polypeptide binding]; other site
665571006062	zinc binding site [ion binding]; other site
665571006063	CDP-binding sites; other site
665571006064	41 helicase; Provisional; Region: 41; PHA02542
665571006065	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
665571006066	elongation factor G; Reviewed; Region: PRK12740
665571006067	G1 box; other site
665571006068	putative GEF interaction site [polypeptide binding]; other site
665571006069	GTP/Mg2+ binding site [chemical binding]; other site
665571006070	Switch I region; other site
665571006071	G2 box; other site
665571006072	G3 box; other site
665571006073	Switch II region; other site
665571006074	G4 box; other site
665571006075	G5 box; other site
665571006076	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
665571006077	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
665571006078	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
665571006079	FOG: CBS domain [General function prediction only]; Region: COG0517
665571006080	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
665571006081	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
665571006082	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
665571006083	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
665571006084	Walker A/P-loop; other site
665571006085	ATP binding site [chemical binding]; other site
665571006086	Q-loop/lid; other site
665571006087	ABC transporter signature motif; other site
665571006088	Walker B; other site
665571006089	D-loop; other site
665571006090	H-loop/switch region; other site
665571006091	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
665571006092	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
665571006093	Walker A/P-loop; other site
665571006094	ATP binding site [chemical binding]; other site
665571006095	Q-loop/lid; other site
665571006096	ABC transporter signature motif; other site
665571006097	Walker B; other site
665571006098	D-loop; other site
665571006099	H-loop/switch region; other site
665571006100	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
665571006101	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
665571006102	TM-ABC transporter signature motif; other site
665571006103	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
665571006104	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571006105	TM-ABC transporter signature motif; other site
665571006106	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
665571006107	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
665571006108	putative ligand binding site [chemical binding]; other site
665571006109	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
665571006110	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
665571006111	active site
665571006112	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571006113	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
665571006114	TM-ABC transporter signature motif; other site
665571006115	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571006116	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
665571006117	TM-ABC transporter signature motif; other site
665571006118	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
665571006119	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
665571006120	Walker A/P-loop; other site
665571006121	ATP binding site [chemical binding]; other site
665571006122	Q-loop/lid; other site
665571006123	ABC transporter signature motif; other site
665571006124	Walker B; other site
665571006125	D-loop; other site
665571006126	H-loop/switch region; other site
665571006127	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
665571006128	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
665571006129	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
665571006130	putative ligand binding site [chemical binding]; other site
665571006131	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
665571006132	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
665571006133	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
665571006134	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
665571006135	Walker A/P-loop; other site
665571006136	ATP binding site [chemical binding]; other site
665571006137	Q-loop/lid; other site
665571006138	ABC transporter signature motif; other site
665571006139	Walker B; other site
665571006140	D-loop; other site
665571006141	H-loop/switch region; other site
665571006142	NMT1/THI5 like; Region: NMT1; pfam09084
665571006143	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
665571006144	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
665571006145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
665571006146	ABC-ATPase subunit interface; other site
665571006147	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
665571006148	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
665571006149	dimerization interface [polypeptide binding]; other site
665571006150	PAS domain; Region: PAS; smart00091
665571006151	PAS domain S-box; Region: sensory_box; TIGR00229
665571006152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571006153	putative active site [active]
665571006154	heme pocket [chemical binding]; other site
665571006155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571006156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571006157	metal binding site [ion binding]; metal-binding site
665571006158	active site
665571006159	I-site; other site
665571006160	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
665571006161	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
665571006162	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
665571006163	Peptidase M30; Region: Peptidase_M30; pfam10460
665571006164	Bacterial SH3 domain; Region: SH3_3; pfam08239
665571006165	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
665571006166	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571006167	Walker A/P-loop; other site
665571006168	ATP binding site [chemical binding]; other site
665571006169	Q-loop/lid; other site
665571006170	ABC transporter signature motif; other site
665571006171	Walker B; other site
665571006172	D-loop; other site
665571006173	H-loop/switch region; other site
665571006174	ABC transporter; Region: ABC_tran_2; pfam12848
665571006175	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
665571006176	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
665571006177	putative catalytic site [active]
665571006178	putative metal binding site [ion binding]; other site
665571006179	putative phosphate binding site [ion binding]; other site
665571006180	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
665571006181	peptide chain release factor 1; Validated; Region: prfA; PRK00591
665571006182	This domain is found in peptide chain release factors; Region: PCRF; smart00937
665571006183	RF-1 domain; Region: RF-1; pfam00472
665571006184	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
665571006185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571006186	S-adenosylmethionine binding site [chemical binding]; other site
665571006187	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
665571006188	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571006189	Zn2+ binding site [ion binding]; other site
665571006190	Mg2+ binding site [ion binding]; other site
665571006191	Uncharacterized conserved protein [Function unknown]; Region: COG3334
665571006192	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
665571006193	synthetase active site [active]
665571006194	NTP binding site [chemical binding]; other site
665571006195	metal binding site [ion binding]; metal-binding site
665571006196	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
665571006197	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
665571006198	dimer interface [polypeptide binding]; other site
665571006199	catalytic triad [active]
665571006200	peroxidatic and resolving cysteines [active]
665571006201	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571006202	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
665571006203	FtsX-like permease family; Region: FtsX; pfam02687
665571006204	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571006205	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
665571006206	FtsX-like permease family; Region: FtsX; pfam02687
665571006207	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571006208	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
665571006209	Walker A/P-loop; other site
665571006210	ATP binding site [chemical binding]; other site
665571006211	Q-loop/lid; other site
665571006212	ABC transporter signature motif; other site
665571006213	Walker B; other site
665571006214	D-loop; other site
665571006215	H-loop/switch region; other site
665571006216	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
665571006217	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
665571006218	lipoyl-biotinyl attachment site [posttranslational modification]; other site
665571006219	HlyD family secretion protein; Region: HlyD_3; pfam13437
665571006220	Outer membrane efflux protein; Region: OEP; pfam02321
665571006221	Outer membrane efflux protein; Region: OEP; pfam02321
665571006222	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
665571006223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571006224	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
665571006225	putative active site [active]
665571006226	heme pocket [chemical binding]; other site
665571006227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
665571006228	putative active site [active]
665571006229	heme pocket [chemical binding]; other site
665571006230	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571006231	Histidine kinase; Region: HisKA_2; pfam07568
665571006232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571006233	ATP binding site [chemical binding]; other site
665571006234	Mg2+ binding site [ion binding]; other site
665571006235	G-X-G motif; other site
665571006236	Response regulator receiver domain; Region: Response_reg; pfam00072
665571006237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006238	active site
665571006239	phosphorylation site [posttranslational modification]
665571006240	intermolecular recognition site; other site
665571006241	dimerization interface [polypeptide binding]; other site
665571006242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571006243	dimer interface [polypeptide binding]; other site
665571006244	phosphorylation site [posttranslational modification]
665571006245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571006246	ATP binding site [chemical binding]; other site
665571006247	Mg2+ binding site [ion binding]; other site
665571006248	G-X-G motif; other site
665571006249	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
665571006250	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
665571006251	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
665571006252	seryl-tRNA synthetase; Provisional; Region: PRK05431
665571006253	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
665571006254	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
665571006255	dimer interface [polypeptide binding]; other site
665571006256	active site
665571006257	motif 1; other site
665571006258	motif 2; other site
665571006259	motif 3; other site
665571006260	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
665571006261	NeuB family; Region: NeuB; pfam03102
665571006262	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
665571006263	NeuB binding interface [polypeptide binding]; other site
665571006264	putative substrate binding site [chemical binding]; other site
665571006265	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
665571006266	PAS domain S-box; Region: sensory_box; TIGR00229
665571006267	PAS domain; Region: PAS_8; pfam13188
665571006268	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571006269	Histidine kinase; Region: HisKA_2; pfam07568
665571006270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571006271	ATP binding site [chemical binding]; other site
665571006272	Mg2+ binding site [ion binding]; other site
665571006273	G-X-G motif; other site
665571006274	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571006275	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
665571006276	active site
665571006277	motif I; other site
665571006278	motif II; other site
665571006279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571006280	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
665571006281	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
665571006282	active site
665571006283	metal binding site [ion binding]; metal-binding site
665571006284	Amino acid permease; Region: AA_permease_2; pfam13520
665571006285	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
665571006286	Protein export membrane protein; Region: SecD_SecF; pfam02355
665571006287	protein-export membrane protein SecD; Region: secD; TIGR01129
665571006288	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
665571006289	Preprotein translocase subunit; Region: YajC; pfam02699
665571006290	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571006291	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571006292	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571006293	Outer membrane efflux protein; Region: OEP; pfam02321
665571006294	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
665571006295	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
665571006296	HlyD family secretion protein; Region: HlyD_3; pfam13437
665571006297	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
665571006298	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571006299	Walker A/P-loop; other site
665571006300	ATP binding site [chemical binding]; other site
665571006301	Q-loop/lid; other site
665571006302	ABC transporter signature motif; other site
665571006303	Walker B; other site
665571006304	D-loop; other site
665571006305	H-loop/switch region; other site
665571006306	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
665571006307	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
665571006308	Walker A/P-loop; other site
665571006309	ATP binding site [chemical binding]; other site
665571006310	Q-loop/lid; other site
665571006311	ABC transporter signature motif; other site
665571006312	Walker B; other site
665571006313	D-loop; other site
665571006314	H-loop/switch region; other site
665571006315	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
665571006316	ABC-2 type transporter; Region: ABC2_membrane; cl17235
665571006317	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
665571006318	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
665571006319	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
665571006320	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
665571006321	E3 interaction surface; other site
665571006322	lipoyl attachment site [posttranslational modification]; other site
665571006323	e3 binding domain; Region: E3_binding; pfam02817
665571006324	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
665571006325	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
665571006326	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
665571006327	alpha subunit interface [polypeptide binding]; other site
665571006328	TPP binding site [chemical binding]; other site
665571006329	heterodimer interface [polypeptide binding]; other site
665571006330	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
665571006331	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
665571006332	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
665571006333	tetramer interface [polypeptide binding]; other site
665571006334	TPP-binding site [chemical binding]; other site
665571006335	heterodimer interface [polypeptide binding]; other site
665571006336	phosphorylation loop region [posttranslational modification]
665571006337	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
665571006338	heat shock protein 90; Provisional; Region: PRK05218
665571006339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571006340	ATP binding site [chemical binding]; other site
665571006341	Mg2+ binding site [ion binding]; other site
665571006342	G-X-G motif; other site
665571006343	SurA N-terminal domain; Region: SurA_N_3; cl07813
665571006344	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
665571006345	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146
665571006346	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
665571006347	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
665571006348	active site
665571006349	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
665571006350	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
665571006351	Peptidase M16C associated; Region: M16C_assoc; pfam08367
665571006352	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
665571006353	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
665571006354	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
665571006355	tetramer interface [polypeptide binding]; other site
665571006356	TPP-binding site [chemical binding]; other site
665571006357	heterodimer interface [polypeptide binding]; other site
665571006358	phosphorylation loop region [posttranslational modification]
665571006359	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
665571006360	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
665571006361	PYR/PP interface [polypeptide binding]; other site
665571006362	dimer interface [polypeptide binding]; other site
665571006363	TPP binding site [chemical binding]; other site
665571006364	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
665571006365	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
665571006366	E3 interaction surface; other site
665571006367	lipoyl attachment site [posttranslational modification]; other site
665571006368	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
665571006369	dimer interface [polypeptide binding]; other site
665571006370	active site
665571006371	CoA binding pocket [chemical binding]; other site
665571006372	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
665571006373	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
665571006374	putative catalytic cysteine [active]
665571006375	gamma-glutamyl kinase; Provisional; Region: PRK05429
665571006376	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
665571006377	nucleotide binding site [chemical binding]; other site
665571006378	homotetrameric interface [polypeptide binding]; other site
665571006379	putative phosphate binding site [ion binding]; other site
665571006380	putative allosteric binding site; other site
665571006381	PUA domain; Region: PUA; pfam01472
665571006382	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
665571006383	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
665571006384	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
665571006385	UbiA prenyltransferase family; Region: UbiA; pfam01040
665571006386	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
665571006387	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
665571006388	substrate binding pocket [chemical binding]; other site
665571006389	chain length determination region; other site
665571006390	substrate-Mg2+ binding site; other site
665571006391	catalytic residues [active]
665571006392	aspartate-rich region 1; other site
665571006393	active site lid residues [active]
665571006394	aspartate-rich region 2; other site
665571006395	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
665571006396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
665571006397	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
665571006398	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
665571006399	MOFRL family; Region: MOFRL; pfam05161
665571006400	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
665571006401	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
665571006402	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
665571006403	putative FMN binding site [chemical binding]; other site
665571006404	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571006405	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
665571006406	transcription termination factor Rho; Provisional; Region: rho; PRK09376
665571006407	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
665571006408	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
665571006409	RNA binding site [nucleotide binding]; other site
665571006410	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
665571006411	multimer interface [polypeptide binding]; other site
665571006412	Walker A motif; other site
665571006413	ATP binding site [chemical binding]; other site
665571006414	Walker B motif; other site
665571006415	competence damage-inducible protein A; Provisional; Region: PRK00549
665571006416	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
665571006417	putative MPT binding site; other site
665571006418	Competence-damaged protein; Region: CinA; pfam02464
665571006419	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
665571006420	Response regulator receiver domain; Region: Response_reg; pfam00072
665571006421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006422	active site
665571006423	phosphorylation site [posttranslational modification]
665571006424	intermolecular recognition site; other site
665571006425	dimerization interface [polypeptide binding]; other site
665571006426	YARHG domain; Region: YARHG; pfam13308
665571006427	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
665571006428	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
665571006429	ring oligomerisation interface [polypeptide binding]; other site
665571006430	ATP/Mg binding site [chemical binding]; other site
665571006431	stacking interactions; other site
665571006432	hinge regions; other site
665571006433	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
665571006434	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
665571006435	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
665571006436	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
665571006437	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
665571006438	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
665571006439	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
665571006440	arginine repressor; Region: argR_whole; TIGR01529
665571006441	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
665571006442	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
665571006443	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
665571006444	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
665571006445	nucleotide binding site [chemical binding]; other site
665571006446	N-acetyl-L-glutamate binding site [chemical binding]; other site
665571006447	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
665571006448	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
665571006449	inhibitor-cofactor binding pocket; inhibition site
665571006450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571006451	catalytic residue [active]
665571006452	argininosuccinate synthase; Provisional; Region: PRK13820
665571006453	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
665571006454	ANP binding site [chemical binding]; other site
665571006455	Substrate Binding Site II [chemical binding]; other site
665571006456	Substrate Binding Site I [chemical binding]; other site
665571006457	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
665571006458	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
665571006459	active site
665571006460	dimer interface [polypeptide binding]; other site
665571006461	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
665571006462	dimer interface [polypeptide binding]; other site
665571006463	active site
665571006464	enolase; Provisional; Region: eno; PRK00077
665571006465	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
665571006466	dimer interface [polypeptide binding]; other site
665571006467	metal binding site [ion binding]; metal-binding site
665571006468	substrate binding pocket [chemical binding]; other site
665571006469	Acylphosphatase; Region: Acylphosphatase; pfam00708
665571006470	Response regulator receiver domain; Region: Response_reg; pfam00072
665571006471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006472	active site
665571006473	phosphorylation site [posttranslational modification]
665571006474	intermolecular recognition site; other site
665571006475	dimerization interface [polypeptide binding]; other site
665571006476	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
665571006477	DNA binding residues [nucleotide binding]
665571006478	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
665571006479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006480	active site
665571006481	phosphorylation site [posttranslational modification]
665571006482	intermolecular recognition site; other site
665571006483	dimerization interface [polypeptide binding]; other site
665571006484	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
665571006485	CoenzymeA binding site [chemical binding]; other site
665571006486	subunit interaction site [polypeptide binding]; other site
665571006487	PHB binding site; other site
665571006488	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
665571006489	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
665571006490	4Fe-4S binding domain; Region: Fer4_6; pfam12837
665571006491	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
665571006492	hybrid cluster protein; Provisional; Region: PRK05290
665571006493	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
665571006494	ACS interaction site; other site
665571006495	CODH interaction site; other site
665571006496	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
665571006497	ACS interaction site; other site
665571006498	CODH interaction site; other site
665571006499	metal cluster binding site [ion binding]; other site
665571006500	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
665571006501	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
665571006502	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
665571006503	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
665571006504	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
665571006505	TPR repeat; Region: TPR_11; pfam13414
665571006506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571006507	binding surface
665571006508	TPR motif; other site
665571006509	Outer membrane efflux protein; Region: OEP; pfam02321
665571006510	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
665571006511	HlyD family secretion protein; Region: HlyD_3; pfam13437
665571006512	Bacterial Ig-like domain; Region: Big_5; pfam13205
665571006513	Bacterial Ig-like domain; Region: Big_5; pfam13205
665571006514	Bacterial Ig-like domain; Region: Big_5; pfam13205
665571006515	Bacterial Ig-like domain; Region: Big_5; pfam13205
665571006516	Bacterial Ig-like domain; Region: Big_5; pfam13205
665571006517	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
665571006518	Protein export membrane protein; Region: SecD_SecF; cl14618
665571006519	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
665571006520	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
665571006521	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571006522	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
665571006523	putative ADP-ribose binding site [chemical binding]; other site
665571006524	putative active site [active]
665571006525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
665571006526	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
665571006527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571006528	Walker A/P-loop; other site
665571006529	ATP binding site [chemical binding]; other site
665571006530	Q-loop/lid; other site
665571006531	ABC transporter signature motif; other site
665571006532	Walker B; other site
665571006533	D-loop; other site
665571006534	H-loop/switch region; other site
665571006535	ABC-2 type transporter; Region: ABC2_membrane; cl17235
665571006536	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
665571006537	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
665571006538	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
665571006539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
665571006540	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
665571006541	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
665571006542	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
665571006543	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
665571006544	substrate binding site [chemical binding]; other site
665571006545	putative active site [active]
665571006546	putative cosubstrate binding site; other site
665571006547	catalytic site [active]
665571006548	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
665571006549	substrate binding site [chemical binding]; other site
665571006550	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
665571006551	active site
665571006552	catalytic residues [active]
665571006553	metal binding site [ion binding]; metal-binding site
665571006554	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
665571006555	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
665571006556	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
665571006557	DctM-like transporters; Region: DctM; pfam06808
665571006558	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
665571006559	short chain dehydrogenase; Provisional; Region: PRK06181
665571006560	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
665571006561	putative NAD(P) binding site [chemical binding]; other site
665571006562	homotetramer interface [polypeptide binding]; other site
665571006563	active site
665571006564	homodimer interface [polypeptide binding]; other site
665571006565	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
665571006566	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
665571006567	substrate-cofactor binding pocket; other site
665571006568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571006569	catalytic residue [active]
665571006570	monofunctional chorismate mutase, eukaryotic type; Region: CM_pl-yst; TIGR01802
665571006571	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
665571006572	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
665571006573	nudix motif; other site
665571006574	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
665571006575	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
665571006576	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
665571006577	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
665571006578	HflX GTPase family; Region: HflX; cd01878
665571006579	G1 box; other site
665571006580	GTP/Mg2+ binding site [chemical binding]; other site
665571006581	Switch I region; other site
665571006582	G2 box; other site
665571006583	G3 box; other site
665571006584	Switch II region; other site
665571006585	G4 box; other site
665571006586	G5 box; other site
665571006587	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
665571006588	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
665571006589	Ligand Binding Site [chemical binding]; other site
665571006590	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
665571006591	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
665571006592	intersubunit interface [polypeptide binding]; other site
665571006593	active site
665571006594	Zn2+ binding site [ion binding]; other site
665571006595	L-arabinose isomerase; Provisional; Region: PRK02929
665571006596	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
665571006597	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
665571006598	trimer interface [polypeptide binding]; other site
665571006599	putative substrate binding site [chemical binding]; other site
665571006600	putative metal binding site [ion binding]; other site
665571006601	ribulokinase; Provisional; Region: PRK04123
665571006602	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
665571006603	N- and C-terminal domain interface [polypeptide binding]; other site
665571006604	active site
665571006605	MgATP binding site [chemical binding]; other site
665571006606	catalytic site [active]
665571006607	metal binding site [ion binding]; metal-binding site
665571006608	carbohydrate binding site [chemical binding]; other site
665571006609	homodimer interface [polypeptide binding]; other site
665571006610	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
665571006611	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
665571006612	Walker A/P-loop; other site
665571006613	ATP binding site [chemical binding]; other site
665571006614	Q-loop/lid; other site
665571006615	ABC transporter signature motif; other site
665571006616	Walker B; other site
665571006617	D-loop; other site
665571006618	H-loop/switch region; other site
665571006619	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
665571006620	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
665571006621	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
665571006622	TM-ABC transporter signature motif; other site
665571006623	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
665571006624	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
665571006625	ligand binding site [chemical binding]; other site
665571006626	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
665571006627	DNA binding site [nucleotide binding]
665571006628	domain linker motif; other site
665571006629	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
665571006630	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
665571006631	ligand binding site [chemical binding]; other site
665571006632	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571006633	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
665571006634	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
665571006635	FAD binding pocket [chemical binding]; other site
665571006636	FAD binding motif [chemical binding]; other site
665571006637	phosphate binding motif [ion binding]; other site
665571006638	beta-alpha-beta structure motif; other site
665571006639	NAD binding pocket [chemical binding]; other site
665571006640	Iron coordination center [ion binding]; other site
665571006641	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
665571006642	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
665571006643	heterodimer interface [polypeptide binding]; other site
665571006644	active site
665571006645	FMN binding site [chemical binding]; other site
665571006646	homodimer interface [polypeptide binding]; other site
665571006647	substrate binding site [chemical binding]; other site
665571006648	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
665571006649	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
665571006650	minor groove reading motif; other site
665571006651	helix-hairpin-helix signature motif; other site
665571006652	substrate binding pocket [chemical binding]; other site
665571006653	active site
665571006654	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
665571006655	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
665571006656	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
665571006657	endoglucanase; Region: PLN02420
665571006658	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
665571006659	Cellulose binding domain; Region: CBM_3; pfam00942
665571006660	endoglucanase; Region: PLN02420
665571006661	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
665571006662	Cellulose binding domain; Region: CBM_3; smart01067
665571006663	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
665571006664	fumarate hydratase; Reviewed; Region: fumC; PRK00485
665571006665	Class II fumarases; Region: Fumarase_classII; cd01362
665571006666	active site
665571006667	tetramer interface [polypeptide binding]; other site
665571006668	Transposase domain (DUF772); Region: DUF772; pfam05598
665571006669	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
665571006670	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571006671	MULE transposase domain; Region: MULE; pfam10551
665571006672	aconitate hydratase; Validated; Region: PRK09277
665571006673	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
665571006674	substrate binding site [chemical binding]; other site
665571006675	ligand binding site [chemical binding]; other site
665571006676	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
665571006677	substrate binding site [chemical binding]; other site
665571006678	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
665571006679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006680	active site
665571006681	phosphorylation site [posttranslational modification]
665571006682	intermolecular recognition site; other site
665571006683	dimerization interface [polypeptide binding]; other site
665571006684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571006685	Walker A motif; other site
665571006686	ATP binding site [chemical binding]; other site
665571006687	Walker B motif; other site
665571006688	arginine finger; other site
665571006689	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
665571006690	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
665571006691	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
665571006692	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
665571006693	putative RNA binding site [nucleotide binding]; other site
665571006694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571006695	S-adenosylmethionine binding site [chemical binding]; other site
665571006696	2-isopropylmalate synthase; Validated; Region: PRK03739
665571006697	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
665571006698	active site
665571006699	catalytic residues [active]
665571006700	metal binding site [ion binding]; metal-binding site
665571006701	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
665571006702	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
665571006703	putative dimer interface [polypeptide binding]; other site
665571006704	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
665571006705	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
665571006706	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571006707	dimer interface [polypeptide binding]; other site
665571006708	putative CheW interface [polypeptide binding]; other site
665571006709	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
665571006710	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
665571006711	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
665571006712	dimer interface [polypeptide binding]; other site
665571006713	ADP-ribose binding site [chemical binding]; other site
665571006714	active site
665571006715	nudix motif; other site
665571006716	metal binding site [ion binding]; metal-binding site
665571006717	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
665571006718	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
665571006719	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
665571006720	active site
665571006721	catalytic tetrad [active]
665571006722	GTP-binding protein YchF; Reviewed; Region: PRK09601
665571006723	YchF GTPase; Region: YchF; cd01900
665571006724	G1 box; other site
665571006725	GTP/Mg2+ binding site [chemical binding]; other site
665571006726	Switch I region; other site
665571006727	G2 box; other site
665571006728	Switch II region; other site
665571006729	G3 box; other site
665571006730	G4 box; other site
665571006731	G5 box; other site
665571006732	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
665571006733	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
665571006734	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
665571006735	substrate binding site [chemical binding]; other site
665571006736	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
665571006737	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
665571006738	substrate binding site [chemical binding]; other site
665571006739	ligand binding site [chemical binding]; other site
665571006740	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
665571006741	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
665571006742	tetramer interface [polypeptide binding]; other site
665571006743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
665571006744	catalytic residue [active]
665571006745	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
665571006746	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
665571006747	GSH binding site [chemical binding]; other site
665571006748	catalytic residues [active]
665571006749	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571006750	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571006751	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571006752	dimer interface [polypeptide binding]; other site
665571006753	putative CheW interface [polypeptide binding]; other site
665571006754	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
665571006755	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571006756	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571006757	DctM-like transporters; Region: DctM; pfam06808
665571006758	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
665571006759	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
665571006760	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
665571006761	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
665571006762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571006763	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
665571006764	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
665571006765	dimer interface [polypeptide binding]; other site
665571006766	putative CheW interface [polypeptide binding]; other site
665571006767	N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067
665571006768	Protein of unknown function, DUF608; Region: DUF608; pfam04685
665571006769	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
665571006770	beta-galactosidase; Region: BGL; TIGR03356
665571006771	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
665571006772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571006773	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
665571006774	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
665571006775	quinolinate synthetase; Provisional; Region: PRK09375
665571006776	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
665571006777	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571006778	Walker A/P-loop; other site
665571006779	ATP binding site [chemical binding]; other site
665571006780	Q-loop/lid; other site
665571006781	ABC transporter signature motif; other site
665571006782	Walker B; other site
665571006783	D-loop; other site
665571006784	H-loop/switch region; other site
665571006785	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
665571006786	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
665571006787	ABC-ATPase subunit  interface; other site
665571006788	dimer interface [polypeptide binding]; other site
665571006789	putative PBP binding regions; other site
665571006790	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
665571006791	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
665571006792	putative binding site residues; other site
665571006793	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
665571006794	putative active site [active]
665571006795	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
665571006796	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
665571006797	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
665571006798	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
665571006799	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
665571006800	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
665571006801	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
665571006802	B12 binding site [chemical binding]; other site
665571006803	Radical SAM superfamily; Region: Radical_SAM; pfam04055
665571006804	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571006805	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
665571006806	RecX family; Region: RecX; pfam02631
665571006807	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
665571006808	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
665571006809	23S rRNA interface [nucleotide binding]; other site
665571006810	L3 interface [polypeptide binding]; other site
665571006811	glutamate-1-semialdehyde-2,1-aminomutase; Region: hemL; TIGR00713
665571006812	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
665571006813	Part of AAA domain; Region: AAA_19; pfam13245
665571006814	Family description; Region: UvrD_C_2; pfam13538
665571006815	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
665571006816	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
665571006817	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
665571006818	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
665571006819	FeS/SAM binding site; other site
665571006820	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
665571006821	Helix-turn-helix domain; Region: HTH_25; pfam13413
665571006822	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
665571006823	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
665571006824	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
665571006825	AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253
665571006826	nucleotide binding site [chemical binding]; other site
665571006827	homodimeric interface [polypeptide binding]; other site
665571006828	uridine monophosphate binding site [chemical binding]; other site
665571006829	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
665571006830	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
665571006831	Uncharacterized conserved protein [Function unknown]; Region: COG1656
665571006832	Protein of unknown function DUF82; Region: DUF82; pfam01927
665571006833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571006834	binding surface
665571006835	TPR motif; other site
665571006836	Tetratricopeptide repeat; Region: TPR_12; pfam13424
665571006837	TPR repeat; Region: TPR_11; pfam13414
665571006838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571006839	binding surface
665571006840	TPR motif; other site
665571006841	amino acid transporter; Region: 2A0306; TIGR00909
665571006842	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
665571006843	active site
665571006844	phosphorylation site [posttranslational modification]
665571006845	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
665571006846	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571006847	motif II; other site
665571006848	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
665571006849	trimer interface [polypeptide binding]; other site
665571006850	active site
665571006851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
665571006852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
665571006853	metal binding site [ion binding]; metal-binding site
665571006854	active site
665571006855	I-site; other site
665571006856	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
665571006857	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
665571006858	pseudouridine synthase; Region: TIGR00093
665571006859	active site
665571006860	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571006861	MULE transposase domain; Region: MULE; pfam10551
665571006862	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
665571006863	lipoprotein signal peptidase; Provisional; Region: PRK14787
665571006864	Uncharacterized conserved protein [Function unknown]; Region: COG0327
665571006865	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
665571006866	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
665571006867	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
665571006868	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
665571006869	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
665571006870	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
665571006871	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
665571006872	Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968
665571006873	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571006874	dimer interface [polypeptide binding]; other site
665571006875	phosphorylation site [posttranslational modification]
665571006876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571006877	ATP binding site [chemical binding]; other site
665571006878	Mg2+ binding site [ion binding]; other site
665571006879	G-X-G motif; other site
665571006880	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
665571006881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006882	active site
665571006883	phosphorylation site [posttranslational modification]
665571006884	intermolecular recognition site; other site
665571006885	dimerization interface [polypeptide binding]; other site
665571006886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
665571006887	DNA binding site [nucleotide binding]
665571006888	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
665571006889	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
665571006890	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
665571006891	dimer interface [polypeptide binding]; other site
665571006892	active site
665571006893	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
665571006894	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
665571006895	NAD(P) binding site [chemical binding]; other site
665571006896	homotetramer interface [polypeptide binding]; other site
665571006897	homodimer interface [polypeptide binding]; other site
665571006898	active site
665571006899	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
665571006900	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
665571006901	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
665571006902	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
665571006903	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
665571006904	active site
665571006905	catalytic residues [active]
665571006906	metal binding site [ion binding]; metal-binding site
665571006907	homodimer binding site [polypeptide binding]; other site
665571006908	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
665571006909	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
665571006910	carboxyltransferase (CT) interaction site; other site
665571006911	biotinylation site [posttranslational modification]; other site
665571006912	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
665571006913	PilZ domain; Region: PilZ; pfam07238
665571006914	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
665571006915	active site
665571006916	metal-binding site [ion binding]
665571006917	nucleotide-binding site [chemical binding]; other site
665571006918	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
665571006919	FAD binding site [chemical binding]; other site
665571006920	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
665571006921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
665571006922	putative substrate translocation pore; other site
665571006923	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571006924	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571006925	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
665571006926	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
665571006927	Outer membrane efflux protein; Region: OEP; pfam02321
665571006928	Outer membrane efflux protein; Region: OEP; pfam02321
665571006929	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
665571006930	HlyD family secretion protein; Region: HlyD_3; pfam13437
665571006931	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
665571006932	Protein export membrane protein; Region: SecD_SecF; cl14618
665571006933	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
665571006934	Peptidase family U32; Region: Peptidase_U32; pfam01136
665571006935	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
665571006936	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
665571006937	THUMP domain; Region: THUMP; pfam02926
665571006938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571006939	S-adenosylmethionine binding site [chemical binding]; other site
665571006940	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
665571006941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
665571006942	S-adenosylmethionine binding site [chemical binding]; other site
665571006943	Rhomboid family; Region: Rhomboid; pfam01694
665571006944	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
665571006945	Predicted transcriptional regulator [Transcription]; Region: COG3432
665571006946	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
665571006947	dimer interface [polypeptide binding]; other site
665571006948	motif 1; other site
665571006949	active site
665571006950	motif 2; other site
665571006951	motif 3; other site
665571006952	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616
665571006953	tRNA synthetase B5 domain; Region: B5; smart00874
665571006954	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
665571006955	dimer interface [polypeptide binding]; other site
665571006956	motif 1; other site
665571006957	motif 3; other site
665571006958	motif 2; other site
665571006959	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
665571006960	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
665571006961	P-loop; other site
665571006962	Magnesium ion binding site [ion binding]; other site
665571006963	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
665571006964	Magnesium ion binding site [ion binding]; other site
665571006965	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
665571006966	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
665571006967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
665571006968	motif II; other site
665571006969	Domain of unknown function (DUF1287); Region: DUF1287; cl01519
665571006970	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
665571006971	ApbE family; Region: ApbE; pfam02424
665571006972	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
665571006973	P-loop containing region of AAA domain; Region: AAA_29; cl17516
665571006974	AAA domain; Region: AAA_23; pfam13476
665571006975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
665571006976	Q-loop/lid; other site
665571006977	ABC transporter signature motif; other site
665571006978	Walker B; other site
665571006979	D-loop; other site
665571006980	H-loop/switch region; other site
665571006981	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
665571006982	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
665571006983	active site
665571006984	metal binding site [ion binding]; metal-binding site
665571006985	Ferritin-like domain; Region: Ferritin; pfam00210
665571006986	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
665571006987	diiron binding motif [ion binding]; other site
665571006988	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
665571006989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571006990	active site
665571006991	phosphorylation site [posttranslational modification]
665571006992	intermolecular recognition site; other site
665571006993	dimerization interface [polypeptide binding]; other site
665571006994	CheB methylesterase; Region: CheB_methylest; pfam01339
665571006995	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
665571006996	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
665571006997	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
665571006998	CTP synthetase; Validated; Region: pyrG; PRK05380
665571006999	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
665571007000	Catalytic site [active]
665571007001	active site
665571007002	UTP binding site [chemical binding]; other site
665571007003	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
665571007004	active site
665571007005	putative oxyanion hole; other site
665571007006	catalytic triad [active]
665571007007	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
665571007008	OstA-like protein; Region: OstA; cl00844
665571007009	OstA-like protein; Region: OstA; cl00844
665571007010	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
665571007011	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
665571007012	Walker A/P-loop; other site
665571007013	ATP binding site [chemical binding]; other site
665571007014	Q-loop/lid; other site
665571007015	ABC transporter signature motif; other site
665571007016	Walker B; other site
665571007017	D-loop; other site
665571007018	H-loop/switch region; other site
665571007019	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
665571007020	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
665571007021	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
665571007022	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
665571007023	Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482
665571007024	30S subunit binding site; other site
665571007025	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
665571007026	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
665571007027	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
665571007028	Hpr binding site; other site
665571007029	active site
665571007030	homohexamer subunit interaction site [polypeptide binding]; other site
665571007031	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
665571007032	dimerization domain swap beta strand [polypeptide binding]; other site
665571007033	regulatory protein interface [polypeptide binding]; other site
665571007034	active site
665571007035	regulatory phosphorylation site [posttranslational modification]; other site
665571007036	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
665571007037	dimerization interface [polypeptide binding]; other site
665571007038	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
665571007039	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
665571007040	dimer interface [polypeptide binding]; other site
665571007041	phosphorylation site [posttranslational modification]
665571007042	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571007043	ATP binding site [chemical binding]; other site
665571007044	Mg2+ binding site [ion binding]; other site
665571007045	G-X-G motif; other site
665571007046	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
665571007047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
665571007048	active site
665571007049	phosphorylation site [posttranslational modification]
665571007050	intermolecular recognition site; other site
665571007051	dimerization interface [polypeptide binding]; other site
665571007052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571007053	Walker A motif; other site
665571007054	ATP binding site [chemical binding]; other site
665571007055	Walker B motif; other site
665571007056	arginine finger; other site
665571007057	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
665571007058	LexA repressor; Validated; Region: PRK00215
665571007059	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
665571007060	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
665571007061	Catalytic site [active]
665571007062	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
665571007063	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
665571007064	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
665571007065	GIY-YIG motif/motif A; other site
665571007066	active site
665571007067	catalytic site [active]
665571007068	putative DNA binding site [nucleotide binding]; other site
665571007069	metal binding site [ion binding]; metal-binding site
665571007070	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
665571007071	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
665571007072	DNA binding site [nucleotide binding]
665571007073	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
665571007074	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
665571007075	Interdomain contacts; other site
665571007076	Cytokine receptor motif; other site
665571007077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571007078	TPR motif; other site
665571007079	binding surface
665571007080	TPR repeat; Region: TPR_11; pfam13414
665571007081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571007082	binding surface
665571007083	TPR motif; other site
665571007084	TPR repeat; Region: TPR_11; pfam13414
665571007085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571007086	binding surface
665571007087	TPR motif; other site
665571007088	TPR repeat; Region: TPR_11; pfam13414
665571007089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
665571007090	binding surface
665571007091	Tetratricopeptide repeat; Region: TPR_16; pfam13432
665571007092	TPR motif; other site
665571007093	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
665571007094	catalytic core [active]
665571007095	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
665571007096	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
665571007097	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
665571007098	putative active site [active]
665571007099	putative metal binding site [ion binding]; other site
665571007100	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
665571007101	Peptidase family M23; Region: Peptidase_M23; pfam01551
665571007102	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
665571007103	putative efflux protein, MATE family; Region: matE; TIGR00797
665571007104	polyphosphate kinase; Provisional; Region: PRK05443
665571007105	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
665571007106	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
665571007107	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
665571007108	putative domain interface [polypeptide binding]; other site
665571007109	putative active site [active]
665571007110	catalytic site [active]
665571007111	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
665571007112	putative domain interface [polypeptide binding]; other site
665571007113	putative active site [active]
665571007114	catalytic site [active]
665571007115	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
665571007116	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
665571007117	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
665571007118	Zn2+ binding site [ion binding]; other site
665571007119	Mg2+ binding site [ion binding]; other site
665571007120	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
665571007121	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
665571007122	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
665571007123	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
665571007124	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
665571007125	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
665571007126	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
665571007127	Dimer interface [polypeptide binding]; other site
665571007128	anticodon binding site; other site
665571007129	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
665571007130	motif 1; other site
665571007131	dimer interface [polypeptide binding]; other site
665571007132	active site
665571007133	motif 2; other site
665571007134	motif 3; other site
665571007135	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
665571007136	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
665571007137	GatB domain; Region: GatB_Yqey; smart00845
665571007138	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
665571007139	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
665571007140	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686
665571007141	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
665571007142	Trehalase; Region: Trehalase; cl17346
665571007143	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
665571007144	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
665571007145	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
665571007146	FecR protein; Region: FecR; pfam04773
665571007147	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
665571007148	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
665571007149	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
665571007150	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
665571007151	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
665571007152	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
665571007153	anti sigma factor interaction site; other site
665571007154	regulatory phosphorylation site [posttranslational modification]; other site
665571007155	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
665571007156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
665571007157	Mg2+ binding site [ion binding]; other site
665571007158	G-X-G motif; other site
665571007159	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
665571007160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
665571007161	NAD(P) binding site [chemical binding]; other site
665571007162	active site
665571007163	recombination protein RecR; Reviewed; Region: recR; PRK00076
665571007164	RecR protein; Region: RecR; pfam02132
665571007165	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
665571007166	putative active site [active]
665571007167	putative metal-binding site [ion binding]; other site
665571007168	tetramer interface [polypeptide binding]; other site
665571007169	hypothetical protein; Validated; Region: PRK00153
665571007170	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
665571007171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
665571007172	Walker A motif; other site
665571007173	ATP binding site [chemical binding]; other site
665571007174	Walker B motif; other site
665571007175	arginine finger; other site
665571007176	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
665571007177	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
665571007178	active site
665571007179	phosphorylation site [posttranslational modification]
665571007180	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
665571007181	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
665571007182	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571007183	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571007184	FtsX-like permease family; Region: FtsX; pfam02687
665571007185	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
665571007186	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
665571007187	FtsX-like permease family; Region: FtsX; pfam02687
665571007188	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
665571007189	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
665571007190	Walker A/P-loop; other site
665571007191	ATP binding site [chemical binding]; other site
665571007192	Q-loop/lid; other site
665571007193	ABC transporter signature motif; other site
665571007194	Walker B; other site
665571007195	D-loop; other site
665571007196	H-loop/switch region; other site
665571007197	Transcriptional regulators [Transcription]; Region: MarR; COG1846
665571007198	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
665571007199	putative DNA binding site [nucleotide binding]; other site
665571007200	putative Zn2+ binding site [ion binding]; other site
665571007201	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
665571007202	ParB-like nuclease domain; Region: ParBc; pfam02195
665571007203	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
665571007204	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
665571007205	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
665571007206	P-loop; other site
665571007207	Magnesium ion binding site [ion binding]; other site
665571007208	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
665571007209	Magnesium ion binding site [ion binding]; other site
665571007210	NifU-like domain; Region: NifU; cl00484
665571007211	adenosine deaminase; Provisional; Region: PRK09358
665571007212	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
665571007213	active site
665571007214	DNA gyrase subunit A; Validated; Region: PRK05560
665571007215	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
665571007216	CAP-like domain; other site
665571007217	active site
665571007218	primary dimer interface [polypeptide binding]; other site
665571007219	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
665571007220	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
665571007221	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
665571007222	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
665571007223	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
665571007224	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
665571007225	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
665571007226	Mg2+ binding site [ion binding]; other site
665571007227	G-X-G motif; other site
665571007228	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
665571007229	anchoring element; other site
665571007230	dimer interface [polypeptide binding]; other site
665571007231	ATP binding site [chemical binding]; other site
665571007232	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
665571007233	active site
665571007234	putative metal-binding site [ion binding]; other site
665571007235	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
665571007236	Transposase, Mutator family; Region: Transposase_mut; pfam00872
665571007237	MULE transposase domain; Region: MULE; pfam10551