-- dump date 20140620_072546 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869211000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 869211000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 869211000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211000004 Walker A motif; other site 869211000005 ATP binding site [chemical binding]; other site 869211000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869211000007 Walker B motif; other site 869211000008 arginine finger; other site 869211000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869211000010 DnaA box-binding interface [nucleotide binding]; other site 869211000011 DNA polymerase III subunit beta; Provisional; Region: PRK14940 869211000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869211000013 putative DNA binding surface [nucleotide binding]; other site 869211000014 dimer interface [polypeptide binding]; other site 869211000015 beta-clamp/clamp loader binding surface; other site 869211000016 beta-clamp/translesion DNA polymerase binding surface; other site 869211000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 869211000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211000019 Walker A/P-loop; other site 869211000020 ATP binding site [chemical binding]; other site 869211000021 Q-loop/lid; other site 869211000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211000023 ABC transporter signature motif; other site 869211000024 Walker B; other site 869211000025 D-loop; other site 869211000026 H-loop/switch region; other site 869211000027 Protein of unknown function (DUF721); Region: DUF721; pfam05258 869211000028 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 869211000029 Ribonuclease P; Region: Ribonuclease_P; pfam00825 869211000030 Haemolytic domain; Region: Haemolytic; pfam01809 869211000031 membrane protein insertase; Provisional; Region: PRK01318 869211000032 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869211000033 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 869211000034 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 869211000035 G-X-X-G motif; other site 869211000036 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 869211000037 RxxxH motif; other site 869211000038 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 869211000039 lipoyl attachment site [posttranslational modification]; other site 869211000040 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 869211000041 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869211000042 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869211000043 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 869211000044 Adenosylhomocysteinase; Provisional; Region: PTZ00075 869211000045 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 869211000046 homotetramer interface [polypeptide binding]; other site 869211000047 ligand binding site [chemical binding]; other site 869211000048 catalytic site [active] 869211000049 NAD binding site [chemical binding]; other site 869211000050 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869211000051 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869211000052 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869211000053 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869211000054 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 869211000055 putative active site [active] 869211000056 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211000057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000058 active site 869211000059 phosphorylation site [posttranslational modification] 869211000060 intermolecular recognition site; other site 869211000061 dimerization interface [polypeptide binding]; other site 869211000062 PAS fold; Region: PAS; pfam00989 869211000063 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869211000064 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869211000065 active site 869211000066 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869211000067 substrate binding site [chemical binding]; other site 869211000068 catalytic residues [active] 869211000069 dimer interface [polypeptide binding]; other site 869211000070 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 869211000071 GAF domain; Region: GAF_3; pfam13492 869211000072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211000073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211000074 metal binding site [ion binding]; metal-binding site 869211000075 active site 869211000076 I-site; other site 869211000077 Bifunctional nuclease; Region: DNase-RNase; pfam02577 869211000078 UvrB/uvrC motif; Region: UVR; pfam02151 869211000079 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 869211000080 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 869211000081 active site 869211000082 catalytic site [active] 869211000083 NAD synthetase; Provisional; Region: PRK13981 869211000084 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 869211000085 multimer interface [polypeptide binding]; other site 869211000086 active site 869211000087 catalytic triad [active] 869211000088 protein interface 1 [polypeptide binding]; other site 869211000089 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869211000090 homodimer interface [polypeptide binding]; other site 869211000091 NAD binding pocket [chemical binding]; other site 869211000092 ATP binding pocket [chemical binding]; other site 869211000093 Mg binding site [ion binding]; other site 869211000094 active-site loop [active] 869211000095 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 869211000096 prolyl-tRNA synthetase; Provisional; Region: PRK08661 869211000097 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 869211000098 dimer interface [polypeptide binding]; other site 869211000099 motif 1; other site 869211000100 active site 869211000101 motif 2; other site 869211000102 motif 3; other site 869211000103 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 869211000104 anticodon binding site; other site 869211000105 zinc-binding site [ion binding]; other site 869211000106 Predicted secreted protein [Function unknown]; Region: COG5497 869211000107 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 869211000108 6-phosphofructokinase; Provisional; Region: PRK03202 869211000109 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869211000110 active site 869211000111 ADP/pyrophosphate binding site [chemical binding]; other site 869211000112 dimerization interface [polypeptide binding]; other site 869211000113 allosteric effector site; other site 869211000114 fructose-1,6-bisphosphate binding site; other site 869211000115 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 869211000116 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869211000117 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211000118 Zn2+ binding site [ion binding]; other site 869211000119 Mg2+ binding site [ion binding]; other site 869211000120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869211000121 putative acyl-acceptor binding pocket; other site 869211000122 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 869211000123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211000124 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 869211000125 Protein of unknown function (DUF342); Region: DUF342; pfam03961 869211000126 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 869211000127 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 869211000128 P-loop; other site 869211000129 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869211000130 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 869211000131 C-terminal peptidase (prc); Region: prc; TIGR00225 869211000132 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 869211000133 protein binding site [polypeptide binding]; other site 869211000134 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 869211000135 Catalytic dyad [active] 869211000136 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 869211000137 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 869211000138 Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808 869211000139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 869211000140 active site 869211000141 phosphorylation site [posttranslational modification] 869211000142 intermolecular recognition site; other site 869211000143 dimerization interface [polypeptide binding]; other site 869211000144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211000145 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869211000146 Walker A motif; other site 869211000147 ATP binding site [chemical binding]; other site 869211000148 Walker B motif; other site 869211000149 arginine finger; other site 869211000150 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 869211000151 classical (c) SDRs; Region: SDR_c; cd05233 869211000152 NAD(P) binding site [chemical binding]; other site 869211000153 active site 869211000154 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 869211000155 anti sigma factor interaction site; other site 869211000156 regulatory phosphorylation site [posttranslational modification]; other site 869211000157 phage shock protein A; Region: phageshock_pspA; TIGR02977 869211000158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869211000159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869211000160 DNA binding site [nucleotide binding] 869211000161 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 869211000162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869211000163 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 869211000164 putative NAD(P) binding site [chemical binding]; other site 869211000165 active site 869211000166 putative substrate binding site [chemical binding]; other site 869211000167 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869211000168 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869211000169 hinge; other site 869211000170 active site 869211000171 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 869211000172 aspartate kinase; Provisional; Region: PRK06291 869211000173 putative catalytic residues [active] 869211000174 putative nucleotide binding site [chemical binding]; other site 869211000175 putative aspartate binding site [chemical binding]; other site 869211000176 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 869211000177 dimer interface [polypeptide binding]; other site 869211000178 putative threonine allosteric regulatory site; other site 869211000179 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 869211000180 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869211000181 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869211000182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211000183 catalytic residue [active] 869211000184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 869211000185 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 869211000186 putative trimer interface [polypeptide binding]; other site 869211000187 putative CoA binding site [chemical binding]; other site 869211000188 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 869211000189 Predicted membrane protein [Function unknown]; Region: COG2246 869211000190 GtrA-like protein; Region: GtrA; pfam04138 869211000191 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 869211000192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869211000193 active site 869211000194 catalytic tetrad [active] 869211000195 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869211000196 Response regulator receiver domain; Region: Response_reg; pfam00072 869211000197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000198 active site 869211000199 phosphorylation site [posttranslational modification] 869211000200 intermolecular recognition site; other site 869211000201 dimerization interface [polypeptide binding]; other site 869211000202 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 869211000203 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869211000204 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869211000205 PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360 869211000206 Domain of unknown function DUF; Region: DUF204; pfam02659 869211000207 Domain of unknown function DUF; Region: DUF204; pfam02659 869211000208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211000209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211000210 metal binding site [ion binding]; metal-binding site 869211000211 active site 869211000212 I-site; other site 869211000213 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 869211000214 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869211000215 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 869211000216 Part of AAA domain; Region: AAA_19; pfam13245 869211000217 Family description; Region: UvrD_C_2; pfam13538 869211000218 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869211000219 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869211000220 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869211000221 dimer interface [polypeptide binding]; other site 869211000222 active site 869211000223 CoA binding pocket [chemical binding]; other site 869211000224 MG2 domain; Region: A2M_N; pfam01835 869211000225 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 869211000226 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 869211000227 surface patch; other site 869211000228 thioester region; other site 869211000229 specificity defining residues; other site 869211000230 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 869211000231 Transglycosylase; Region: Transgly; pfam00912 869211000232 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869211000233 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 869211000234 Domain of unknown function (DUF377); Region: DUF377; pfam04041 869211000235 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869211000236 active site 869211000237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211000238 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211000239 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869211000240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211000241 dimer interface [polypeptide binding]; other site 869211000242 conserved gate region; other site 869211000243 putative PBP binding loops; other site 869211000244 ABC-ATPase subunit interface; other site 869211000245 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211000246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211000247 dimer interface [polypeptide binding]; other site 869211000248 conserved gate region; other site 869211000249 putative PBP binding loops; other site 869211000250 ABC-ATPase subunit interface; other site 869211000251 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869211000252 sugar binding site [chemical binding]; other site 869211000253 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211000254 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211000255 DNA binding site [nucleotide binding] 869211000256 domain linker motif; other site 869211000257 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211000258 dimerization interface [polypeptide binding]; other site 869211000259 ligand binding site [chemical binding]; other site 869211000260 Domain of unknown function (DUF377); Region: DUF377; pfam04041 869211000261 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869211000262 active site 869211000263 dimerization interface [polypeptide binding]; other site 869211000264 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 869211000265 putative active cleft [active] 869211000266 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 869211000267 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211000268 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 869211000269 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 869211000270 catalytic triad [active] 869211000271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869211000272 active site 869211000273 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 869211000274 active site 2 [active] 869211000275 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 869211000276 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211000277 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000278 dimer interface [polypeptide binding]; other site 869211000279 putative CheW interface [polypeptide binding]; other site 869211000280 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869211000281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211000282 active site 869211000283 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 869211000284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211000285 active site 869211000286 Response regulator receiver domain; Region: Response_reg; pfam00072 869211000287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000288 active site 869211000289 phosphorylation site [posttranslational modification] 869211000290 intermolecular recognition site; other site 869211000291 dimerization interface [polypeptide binding]; other site 869211000292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211000293 dimer interface [polypeptide binding]; other site 869211000294 phosphorylation site [posttranslational modification] 869211000295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211000296 ATP binding site [chemical binding]; other site 869211000297 Mg2+ binding site [ion binding]; other site 869211000298 G-X-G motif; other site 869211000299 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 869211000300 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869211000301 FMN binding site [chemical binding]; other site 869211000302 active site 869211000303 catalytic residues [active] 869211000304 substrate binding site [chemical binding]; other site 869211000305 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 869211000306 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 869211000307 ligand binding site [chemical binding]; other site 869211000308 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211000309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000310 dimer interface [polypeptide binding]; other site 869211000311 putative CheW interface [polypeptide binding]; other site 869211000312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211000313 dimerization interface [polypeptide binding]; other site 869211000314 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 869211000315 cyclase homology domain; Region: CHD; cd07302 869211000316 nucleotidyl binding site; other site 869211000317 metal binding site [ion binding]; metal-binding site 869211000318 dimer interface [polypeptide binding]; other site 869211000319 TPR repeat; Region: TPR_11; pfam13414 869211000320 binding surface 869211000321 Tetratricopeptide repeat; Region: TPR_2; pfam07719 869211000322 Cache domain; Region: Cache_2; pfam08269 869211000323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000324 dimer interface [polypeptide binding]; other site 869211000325 putative CheW interface [polypeptide binding]; other site 869211000326 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 869211000327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000328 dimer interface [polypeptide binding]; other site 869211000329 putative CheW interface [polypeptide binding]; other site 869211000330 pyruvate kinase; Provisional; Region: PRK05826 869211000331 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 869211000332 domain interfaces; other site 869211000333 active site 869211000334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211000335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869211000336 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 869211000337 HEAT-like repeat; Region: HEAT_EZ; pfam13513 869211000338 protein binding surface [polypeptide binding]; other site 869211000339 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869211000340 putative binding surface; other site 869211000341 active site 869211000342 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 869211000343 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 869211000344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211000345 ATP binding site [chemical binding]; other site 869211000346 Mg2+ binding site [ion binding]; other site 869211000347 G-X-G motif; other site 869211000348 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 869211000349 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211000350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000351 active site 869211000352 phosphorylation site [posttranslational modification] 869211000353 intermolecular recognition site; other site 869211000354 dimerization interface [polypeptide binding]; other site 869211000355 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 869211000356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000357 dimer interface [polypeptide binding]; other site 869211000358 putative CheW interface [polypeptide binding]; other site 869211000359 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 869211000360 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 869211000361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211000362 S-adenosylmethionine binding site [chemical binding]; other site 869211000363 CheD chemotactic sensory transduction; Region: CheD; cl00810 869211000364 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 869211000365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000366 active site 869211000367 phosphorylation site [posttranslational modification] 869211000368 intermolecular recognition site; other site 869211000369 dimerization interface [polypeptide binding]; other site 869211000370 CheB methylesterase; Region: CheB_methylest; pfam01339 869211000371 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 869211000372 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 869211000373 substrate binding site [chemical binding]; other site 869211000374 ligand binding site [chemical binding]; other site 869211000375 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 869211000376 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869211000377 substrate binding site [chemical binding]; other site 869211000378 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 869211000379 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 869211000380 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869211000381 Domain of unknown function DUF21; Region: DUF21; pfam01595 869211000382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869211000383 Transporter associated domain; Region: CorC_HlyC; smart01091 869211000384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869211000385 catalytic residues [active] 869211000386 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 869211000387 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 869211000388 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869211000389 phosphate binding site [ion binding]; other site 869211000390 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 869211000391 metal binding site [ion binding]; metal-binding site 869211000392 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869211000393 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 869211000394 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869211000395 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869211000396 TPP-binding site [chemical binding]; other site 869211000397 dimer interface [polypeptide binding]; other site 869211000398 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869211000399 PYR/PP interface [polypeptide binding]; other site 869211000400 dimer interface [polypeptide binding]; other site 869211000401 TPP binding site [chemical binding]; other site 869211000402 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 869211000403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211000404 nucleotide binding site [chemical binding]; other site 869211000405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000406 TPR motif; other site 869211000407 binding surface 869211000408 TPR repeat; Region: TPR_11; pfam13414 869211000409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000410 binding surface 869211000411 TPR motif; other site 869211000412 TPR repeat; Region: TPR_11; pfam13414 869211000413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000414 binding surface 869211000415 TPR motif; other site 869211000416 DHH family; Region: DHH; pfam01368 869211000417 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 869211000418 Uncharacterized conserved protein [Function unknown]; Region: COG1434 869211000419 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 869211000420 putative active site [active] 869211000421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211000422 dimer interface [polypeptide binding]; other site 869211000423 phosphorylation site [posttranslational modification] 869211000424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211000425 ATP binding site [chemical binding]; other site 869211000426 Mg2+ binding site [ion binding]; other site 869211000427 G-X-G motif; other site 869211000428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000429 active site 869211000430 phosphorylation site [posttranslational modification] 869211000431 intermolecular recognition site; other site 869211000432 dimerization interface [polypeptide binding]; other site 869211000433 DNA repair protein RadA; Provisional; Region: PRK11823 869211000434 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869211000435 Walker A motif; other site 869211000436 ATP binding site [chemical binding]; other site 869211000437 Walker B motif; other site 869211000438 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 869211000439 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 869211000440 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 869211000441 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869211000442 thiamine phosphate binding site [chemical binding]; other site 869211000443 active site 869211000444 pyrophosphate binding site [ion binding]; other site 869211000445 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 869211000446 ATP binding site [chemical binding]; other site 869211000447 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 869211000448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211000449 FeS/SAM binding site; other site 869211000450 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 869211000451 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 869211000452 ThiS interaction site; other site 869211000453 putative active site [active] 869211000454 tetramer interface [polypeptide binding]; other site 869211000455 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 869211000456 thiS-thiF/thiG interaction site; other site 869211000457 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 869211000458 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 869211000459 putative ligand binding site [chemical binding]; other site 869211000460 putative NAD binding site [chemical binding]; other site 869211000461 putative catalytic site [active] 869211000462 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 869211000463 L-serine binding site [chemical binding]; other site 869211000464 ACT domain interface; other site 869211000465 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 869211000466 homodimer interface [polypeptide binding]; other site 869211000467 substrate-cofactor binding pocket; other site 869211000468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211000469 catalytic residue [active] 869211000470 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 869211000471 CoA binding domain; Region: CoA_binding; smart00881 869211000472 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 869211000473 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 869211000474 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 869211000475 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211000476 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 869211000477 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 869211000478 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869211000479 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869211000480 dimer interface [polypeptide binding]; other site 869211000481 anticodon binding site; other site 869211000482 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869211000483 homodimer interface [polypeptide binding]; other site 869211000484 motif 1; other site 869211000485 active site 869211000486 motif 2; other site 869211000487 GAD domain; Region: GAD; pfam02938 869211000488 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869211000489 motif 3; other site 869211000490 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869211000491 Cation efflux family; Region: Cation_efflux; pfam01545 869211000492 Predicted methyltransferases [General function prediction only]; Region: COG0313 869211000493 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869211000494 putative SAM binding site [chemical binding]; other site 869211000495 putative homodimer interface [polypeptide binding]; other site 869211000496 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 869211000497 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 869211000498 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 869211000499 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869211000500 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 869211000501 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869211000502 catalytic residues [active] 869211000503 HDOD domain; Region: HDOD; pfam08668 869211000504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211000505 Zn2+ binding site [ion binding]; other site 869211000506 Mg2+ binding site [ion binding]; other site 869211000507 AAA domain; Region: AAA_32; pfam13654 869211000508 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 869211000509 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 869211000510 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 869211000511 putative active site [active] 869211000512 putative CoA binding site [chemical binding]; other site 869211000513 nudix motif; other site 869211000514 metal binding site [ion binding]; metal-binding site 869211000515 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 869211000516 putative FMN binding site [chemical binding]; other site 869211000517 serine hydroxymethyltransferase; Provisional; Region: PRK13580 869211000518 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869211000519 dimer interface [polypeptide binding]; other site 869211000520 active site 869211000521 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869211000522 folate binding site [chemical binding]; other site 869211000523 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 869211000524 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 869211000525 glycogen binding site [chemical binding]; other site 869211000526 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 869211000527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000528 binding surface 869211000529 TPR motif; other site 869211000530 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869211000531 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869211000532 homodimer interface [polypeptide binding]; other site 869211000533 substrate-cofactor binding pocket; other site 869211000534 catalytic residue [active] 869211000535 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 869211000536 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 869211000537 Substrate binding site; other site 869211000538 Cupin domain; Region: Cupin_2; cl17218 869211000539 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 869211000540 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869211000541 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869211000542 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 869211000543 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869211000544 glutamine binding [chemical binding]; other site 869211000545 catalytic triad [active] 869211000546 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869211000547 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869211000548 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869211000549 active site 869211000550 ribulose/triose binding site [chemical binding]; other site 869211000551 phosphate binding site [ion binding]; other site 869211000552 substrate (anthranilate) binding pocket [chemical binding]; other site 869211000553 product (indole) binding pocket [chemical binding]; other site 869211000554 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869211000555 active site 869211000556 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869211000557 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869211000558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211000559 catalytic residue [active] 869211000560 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869211000561 substrate binding site [chemical binding]; other site 869211000562 active site 869211000563 catalytic residues [active] 869211000564 heterodimer interface [polypeptide binding]; other site 869211000565 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869211000566 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869211000567 catalytic residues [active] 869211000568 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 869211000569 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869211000570 ligand binding site [chemical binding]; other site 869211000571 flexible hinge region; other site 869211000572 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869211000573 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869211000574 glutaminase active site [active] 869211000575 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869211000576 dimer interface [polypeptide binding]; other site 869211000577 active site 869211000578 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869211000579 dimer interface [polypeptide binding]; other site 869211000580 active site 869211000581 Integrin, beta chain; Region: Integrin_beta; cl17693 869211000582 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 869211000583 Protein of unknown function (DUF554); Region: DUF554; pfam04474 869211000584 homoserine dehydrogenase; Provisional; Region: PRK06349 869211000585 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869211000586 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869211000587 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 869211000588 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 869211000589 FecR protein; Region: FecR; pfam04773 869211000590 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869211000591 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869211000592 Walker A/P-loop; other site 869211000593 ATP binding site [chemical binding]; other site 869211000594 Q-loop/lid; other site 869211000595 ABC transporter signature motif; other site 869211000596 Walker B; other site 869211000597 D-loop; other site 869211000598 H-loop/switch region; other site 869211000599 TOBE domain; Region: TOBE_2; pfam08402 869211000600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869211000601 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869211000602 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211000603 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000604 dimer interface [polypeptide binding]; other site 869211000605 putative CheW interface [polypeptide binding]; other site 869211000606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869211000607 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 869211000608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211000609 homodimer interface [polypeptide binding]; other site 869211000610 catalytic residue [active] 869211000611 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 869211000612 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211000613 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211000614 FtsX-like permease family; Region: FtsX; pfam02687 869211000615 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211000616 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211000617 FtsX-like permease family; Region: FtsX; pfam02687 869211000618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211000619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869211000620 Walker A/P-loop; other site 869211000621 ATP binding site [chemical binding]; other site 869211000622 Q-loop/lid; other site 869211000623 ABC transporter signature motif; other site 869211000624 Walker B; other site 869211000625 D-loop; other site 869211000626 H-loop/switch region; other site 869211000627 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211000628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211000629 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 869211000630 oligomerization interface [polypeptide binding]; other site 869211000631 active site 869211000632 metal binding site [ion binding]; metal-binding site 869211000633 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 869211000634 Flavoprotein; Region: Flavoprotein; pfam02441 869211000635 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 869211000636 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 869211000637 tetramerization interface [polypeptide binding]; other site 869211000638 active site 869211000639 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 869211000640 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 869211000641 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 869211000642 substrate binding pocket [chemical binding]; other site 869211000643 dimer interface [polypeptide binding]; other site 869211000644 inhibitor binding site; inhibition site 869211000645 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 869211000646 B12 binding site [chemical binding]; other site 869211000647 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 869211000648 hypothetical protein; Provisional; Region: PRK13761 869211000649 Predicted archaeal kinase (sugar kinase superfamily) [General function prediction only]; Region: COG1829 869211000650 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869211000651 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 869211000652 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 869211000653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000654 putative CheW interface [polypeptide binding]; other site 869211000655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211000656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211000657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211000658 dimer interface [polypeptide binding]; other site 869211000659 phosphorylation site [posttranslational modification] 869211000660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211000661 ATP binding site [chemical binding]; other site 869211000662 Mg2+ binding site [ion binding]; other site 869211000663 G-X-G motif; other site 869211000664 Response regulator receiver domain; Region: Response_reg; pfam00072 869211000665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000666 active site 869211000667 phosphorylation site [posttranslational modification] 869211000668 intermolecular recognition site; other site 869211000669 dimerization interface [polypeptide binding]; other site 869211000670 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869211000671 putative binding surface; other site 869211000672 active site 869211000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211000674 putative substrate translocation pore; other site 869211000675 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 869211000676 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 869211000677 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869211000678 homotrimer interaction site [polypeptide binding]; other site 869211000679 putative active site [active] 869211000680 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 869211000681 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 869211000682 anti sigma factor interaction site; other site 869211000683 regulatory phosphorylation site [posttranslational modification]; other site 869211000684 Membrane transport protein; Region: Mem_trans; cl09117 869211000685 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 869211000686 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 869211000687 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869211000688 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 869211000689 active site 869211000690 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869211000691 TSCPD domain; Region: TSCPD; pfam12637 869211000692 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869211000693 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 869211000694 non-heme iron binding site [ion binding]; other site 869211000695 tetramer interface [polypeptide binding]; other site 869211000696 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 869211000697 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 869211000698 putative active site [active] 869211000699 PhoH-like protein; Region: PhoH; pfam02562 869211000700 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869211000701 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 869211000702 NodB motif; other site 869211000703 active site 869211000704 catalytic site [active] 869211000705 metal binding site [ion binding]; metal-binding site 869211000706 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 869211000707 FlgN protein; Region: FlgN; pfam05130 869211000708 DNA polymerase I; Provisional; Region: PRK05755 869211000709 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869211000710 active site 869211000711 metal binding site 1 [ion binding]; metal-binding site 869211000712 putative 5' ssDNA interaction site; other site 869211000713 metal binding site 3; metal-binding site 869211000714 metal binding site 2 [ion binding]; metal-binding site 869211000715 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869211000716 putative DNA binding site [nucleotide binding]; other site 869211000717 putative metal binding site [ion binding]; other site 869211000718 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 869211000719 active site 869211000720 catalytic site [active] 869211000721 substrate binding site [chemical binding]; other site 869211000722 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869211000723 active site 869211000724 DNA binding site [nucleotide binding] 869211000725 catalytic site [active] 869211000726 Sporulation related domain; Region: SPOR; pfam05036 869211000727 serine O-acetyltransferase; Region: cysE; TIGR01172 869211000728 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869211000729 trimer interface [polypeptide binding]; other site 869211000730 active site 869211000731 substrate binding site [chemical binding]; other site 869211000732 CoA binding site [chemical binding]; other site 869211000733 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 869211000734 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 869211000735 active site 869211000736 nucleophile elbow; other site 869211000737 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211000738 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869211000739 ligand binding site [chemical binding]; other site 869211000740 dimerization interface [polypeptide binding]; other site 869211000741 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 869211000742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000743 dimer interface [polypeptide binding]; other site 869211000744 putative CheW interface [polypeptide binding]; other site 869211000745 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211000746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211000747 dimer interface [polypeptide binding]; other site 869211000748 putative CheW interface [polypeptide binding]; other site 869211000749 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 869211000750 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869211000751 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869211000752 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869211000753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211000754 putative DNA binding site [nucleotide binding]; other site 869211000755 putative Zn2+ binding site [ion binding]; other site 869211000756 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869211000757 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211000758 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 869211000759 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869211000760 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 869211000761 Ligand binding site; other site 869211000762 Putative Catalytic site; other site 869211000763 DXD motif; other site 869211000764 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 869211000765 metal binding site [ion binding]; metal-binding site 869211000766 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869211000767 active site 869211000768 catalytic residues [active] 869211000769 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 869211000770 active site 869211000771 ADP/pyrophosphate binding site [chemical binding]; other site 869211000772 dimerization interface [polypeptide binding]; other site 869211000773 allosteric effector site; other site 869211000774 fructose-1,6-bisphosphate binding site; other site 869211000775 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 869211000776 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869211000777 dimer interface [polypeptide binding]; other site 869211000778 active site 869211000779 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 869211000780 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 869211000781 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 869211000782 active site 869211000783 catalytic residues [active] 869211000784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211000785 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211000786 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869211000787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211000788 dimer interface [polypeptide binding]; other site 869211000789 conserved gate region; other site 869211000790 putative PBP binding loops; other site 869211000791 ABC-ATPase subunit interface; other site 869211000792 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211000793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211000794 dimer interface [polypeptide binding]; other site 869211000795 conserved gate region; other site 869211000796 putative PBP binding loops; other site 869211000797 ABC-ATPase subunit interface; other site 869211000798 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 869211000799 putative active site [active] 869211000800 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 869211000801 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 869211000802 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 869211000803 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869211000804 active site 869211000805 ADP/pyrophosphate binding site [chemical binding]; other site 869211000806 dimerization interface [polypeptide binding]; other site 869211000807 allosteric effector site; other site 869211000808 fructose-1,6-bisphosphate binding site; other site 869211000809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869211000810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869211000811 active site 869211000812 metal binding site [ion binding]; metal-binding site 869211000813 peroxiredoxin; Provisional; Region: PRK13189 869211000814 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 869211000815 dimer interface [polypeptide binding]; other site 869211000816 decamer (pentamer of dimers) interface [polypeptide binding]; other site 869211000817 catalytic triad [active] 869211000818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211000819 Histidine kinase; Region: HisKA_2; pfam07568 869211000820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211000821 ATP binding site [chemical binding]; other site 869211000822 Mg2+ binding site [ion binding]; other site 869211000823 G-X-G motif; other site 869211000824 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 869211000825 circadian clock protein KaiC; Reviewed; Region: PRK09302 869211000826 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869211000827 Walker A motif; other site 869211000828 ATP binding site [chemical binding]; other site 869211000829 Walker B motif; other site 869211000830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869211000831 ATP binding site [chemical binding]; other site 869211000832 Walker A motif; other site 869211000833 Walker B motif; other site 869211000834 Transposase domain (DUF772); Region: DUF772; pfam05598 869211000835 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211000836 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211000837 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 869211000838 dimerization interface [polypeptide binding]; other site 869211000839 ligand binding site [chemical binding]; other site 869211000840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211000841 PAS fold; Region: PAS; pfam00989 869211000842 putative active site [active] 869211000843 heme pocket [chemical binding]; other site 869211000844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869211000845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869211000846 DNA binding residues [nucleotide binding] 869211000847 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869211000848 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869211000849 motif 1; other site 869211000850 dimer interface [polypeptide binding]; other site 869211000851 active site 869211000852 motif 2; other site 869211000853 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869211000854 putative deacylase active site [active] 869211000855 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869211000856 active site 869211000857 motif 3; other site 869211000858 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 869211000859 anticodon binding site; other site 869211000860 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 869211000861 Phosphate acyltransferases; Region: PlsC; smart00563 869211000862 putative acyl-acceptor binding pocket; other site 869211000863 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869211000864 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869211000865 peptide binding site [polypeptide binding]; other site 869211000866 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 869211000867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211000868 dimer interface [polypeptide binding]; other site 869211000869 conserved gate region; other site 869211000870 putative PBP binding loops; other site 869211000871 ABC-ATPase subunit interface; other site 869211000872 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869211000873 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 869211000874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211000875 dimer interface [polypeptide binding]; other site 869211000876 conserved gate region; other site 869211000877 putative PBP binding loops; other site 869211000878 ABC-ATPase subunit interface; other site 869211000879 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869211000880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869211000881 Walker A/P-loop; other site 869211000882 ATP binding site [chemical binding]; other site 869211000883 Q-loop/lid; other site 869211000884 ABC transporter signature motif; other site 869211000885 Walker B; other site 869211000886 D-loop; other site 869211000887 H-loop/switch region; other site 869211000888 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 869211000889 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 869211000890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869211000891 Walker A/P-loop; other site 869211000892 ATP binding site [chemical binding]; other site 869211000893 Q-loop/lid; other site 869211000894 ABC transporter signature motif; other site 869211000895 Walker B; other site 869211000896 D-loop; other site 869211000897 H-loop/switch region; other site 869211000898 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 869211000899 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 869211000900 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 869211000901 glutamine synthetase, type I; Region: GlnA; TIGR00653 869211000902 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869211000903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869211000904 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 869211000905 peptidase T; Region: peptidase-T; TIGR01882 869211000906 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 869211000907 metal binding site [ion binding]; metal-binding site 869211000908 dimer interface [polypeptide binding]; other site 869211000909 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869211000910 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869211000911 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869211000912 G1 box; other site 869211000913 GTP/Mg2+ binding site [chemical binding]; other site 869211000914 Switch I region; other site 869211000915 G2 box; other site 869211000916 Switch II region; other site 869211000917 G3 box; other site 869211000918 G4 box; other site 869211000919 G5 box; other site 869211000920 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869211000921 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869211000922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869211000923 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869211000924 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869211000925 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869211000926 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 869211000927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000928 TPR motif; other site 869211000929 binding surface 869211000930 TPR repeat; Region: TPR_11; pfam13414 869211000931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000932 TPR motif; other site 869211000933 binding surface 869211000934 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211000935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211000936 binding surface 869211000937 TPR motif; other site 869211000938 Restriction endonuclease; Region: Mrr_cat; pfam04471 869211000939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211000940 metal binding site [ion binding]; metal-binding site 869211000941 active site 869211000942 I-site; other site 869211000943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869211000944 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869211000945 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869211000946 active site 869211000947 catalytic residue [active] 869211000948 dimer interface [polypeptide binding]; other site 869211000949 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 869211000950 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869211000951 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869211000952 shikimate binding site; other site 869211000953 NAD(P) binding site [chemical binding]; other site 869211000954 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 869211000955 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 869211000956 NAD(P) binding pocket [chemical binding]; other site 869211000957 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 869211000958 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 869211000959 dimer interface [polypeptide binding]; other site 869211000960 active site 869211000961 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869211000962 catalytic residues [active] 869211000963 substrate binding site [chemical binding]; other site 869211000964 agmatinase; Region: agmatinase; TIGR01230 869211000965 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 869211000966 putative active site [active] 869211000967 Mn binding site [ion binding]; other site 869211000968 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 869211000969 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 869211000970 acyl-activating enzyme (AAE) consensus motif; other site 869211000971 putative AMP binding site [chemical binding]; other site 869211000972 putative active site [active] 869211000973 putative CoA binding site [chemical binding]; other site 869211000974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211000975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 869211000976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211000977 ATP binding site [chemical binding]; other site 869211000978 Mg2+ binding site [ion binding]; other site 869211000979 G-X-G motif; other site 869211000980 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869211000981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211000982 active site 869211000983 phosphorylation site [posttranslational modification] 869211000984 intermolecular recognition site; other site 869211000985 dimerization interface [polypeptide binding]; other site 869211000986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211000987 Walker A motif; other site 869211000988 ATP binding site [chemical binding]; other site 869211000989 Walker B motif; other site 869211000990 arginine finger; other site 869211000991 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869211000992 Omptin family; Region: Omptin; cl01886 869211000993 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 869211000994 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 869211000995 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 869211000996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211000997 ATP binding site [chemical binding]; other site 869211000998 putative Mg++ binding site [ion binding]; other site 869211000999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869211001000 nucleotide binding region [chemical binding]; other site 869211001001 ATP-binding site [chemical binding]; other site 869211001002 lipoyl synthase; Provisional; Region: PRK05481 869211001003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211001004 FeS/SAM binding site; other site 869211001005 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 869211001006 FMN-binding domain; Region: FMN_bind; cl01081 869211001007 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 869211001008 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 869211001009 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 869211001010 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869211001011 catalytic loop [active] 869211001012 iron binding site [ion binding]; other site 869211001013 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 869211001014 FAD binding pocket [chemical binding]; other site 869211001015 conserved FAD binding motif [chemical binding]; other site 869211001016 phosphate binding motif [ion binding]; other site 869211001017 beta-alpha-beta structure motif; other site 869211001018 NAD binding pocket [chemical binding]; other site 869211001019 HEPN domain; Region: HEPN; pfam05168 869211001020 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211001021 active site 869211001022 NTP binding site [chemical binding]; other site 869211001023 metal binding triad [ion binding]; metal-binding site 869211001024 antibiotic binding site [chemical binding]; other site 869211001025 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 869211001026 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 869211001027 putative active site [active] 869211001028 catalytic triad [active] 869211001029 putative dimer interface [polypeptide binding]; other site 869211001030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211001031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211001032 Walker A/P-loop; other site 869211001033 ATP binding site [chemical binding]; other site 869211001034 Q-loop/lid; other site 869211001035 ABC transporter signature motif; other site 869211001036 Walker B; other site 869211001037 D-loop; other site 869211001038 H-loop/switch region; other site 869211001039 PAS domain; Region: PAS; smart00091 869211001040 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869211001041 putative active site [active] 869211001042 heme pocket [chemical binding]; other site 869211001043 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 869211001044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211001045 ATP binding site [chemical binding]; other site 869211001046 Mg2+ binding site [ion binding]; other site 869211001047 G-X-G motif; other site 869211001048 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869211001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001050 active site 869211001051 phosphorylation site [posttranslational modification] 869211001052 intermolecular recognition site; other site 869211001053 dimerization interface [polypeptide binding]; other site 869211001054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211001055 Walker A motif; other site 869211001056 ATP binding site [chemical binding]; other site 869211001057 Walker B motif; other site 869211001058 arginine finger; other site 869211001059 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 869211001060 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 869211001061 putative ligand binding site [chemical binding]; other site 869211001062 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 869211001063 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869211001064 Walker A/P-loop; other site 869211001065 ATP binding site [chemical binding]; other site 869211001066 Q-loop/lid; other site 869211001067 ABC transporter signature motif; other site 869211001068 Walker B; other site 869211001069 D-loop; other site 869211001070 H-loop/switch region; other site 869211001071 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869211001072 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211001073 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869211001074 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869211001075 TM-ABC transporter signature motif; other site 869211001076 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 869211001077 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869211001078 active site 869211001079 HIGH motif; other site 869211001080 KMSKS motif; other site 869211001081 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869211001082 tRNA binding surface [nucleotide binding]; other site 869211001083 anticodon binding site; other site 869211001084 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 869211001085 putative tRNA-binding site [nucleotide binding]; other site 869211001086 FemAB family; Region: FemAB; pfam02388 869211001087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 869211001088 FemAB family; Region: FemAB; pfam02388 869211001089 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 869211001090 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 869211001091 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 869211001092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869211001093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869211001094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211001095 AAA domain; Region: AAA_21; pfam13304 869211001096 Walker A/P-loop; other site 869211001097 ATP binding site [chemical binding]; other site 869211001098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211001099 Walker B; other site 869211001100 D-loop; other site 869211001101 H-loop/switch region; other site 869211001102 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 869211001103 AMMECR1; Region: AMMECR1; pfam01871 869211001104 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 869211001105 putative ligand binding pocket/active site [active] 869211001106 putative metal binding site [ion binding]; other site 869211001107 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 869211001108 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869211001109 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869211001110 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869211001111 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869211001112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869211001113 histidinol dehydrogenase; Region: hisD; TIGR00069 869211001114 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 869211001115 NAD binding site [chemical binding]; other site 869211001116 dimerization interface [polypeptide binding]; other site 869211001117 product binding site; other site 869211001118 substrate binding site [chemical binding]; other site 869211001119 zinc binding site [ion binding]; other site 869211001120 catalytic residues [active] 869211001121 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 869211001122 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 869211001123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211001124 ABC transporter signature motif; other site 869211001125 Walker B; other site 869211001126 D-loop; other site 869211001127 ammonium transporter; Region: amt; TIGR00836 869211001128 dimerization interface [polypeptide binding]; other site 869211001129 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 869211001130 PAS domain; Region: PAS; smart00091 869211001131 PAS fold; Region: PAS; pfam00989 869211001132 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869211001133 putative binding surface; other site 869211001134 active site 869211001135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211001136 ATP binding site [chemical binding]; other site 869211001137 Mg2+ binding site [ion binding]; other site 869211001138 G-X-G motif; other site 869211001139 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 869211001140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001141 Response regulator receiver domain; Region: Response_reg; pfam00072 869211001142 active site 869211001143 phosphorylation site [posttranslational modification] 869211001144 intermolecular recognition site; other site 869211001145 dimerization interface [polypeptide binding]; other site 869211001146 Uncharacterized conserved protein [Function unknown]; Region: COG0432 869211001147 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 869211001148 nucleotide binding site/active site [active] 869211001149 HIT family signature motif; other site 869211001150 catalytic residue [active] 869211001151 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869211001152 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 869211001153 hinge; other site 869211001154 active site 869211001155 PAS fold; Region: PAS_4; pfam08448 869211001156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211001157 putative active site [active] 869211001158 heme pocket [chemical binding]; other site 869211001159 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211001160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211001161 metal binding site [ion binding]; metal-binding site 869211001162 active site 869211001163 I-site; other site 869211001164 Chemotaxis phosphatase CheX; Region: CheX; cl15816 869211001165 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 869211001166 Response regulator receiver domain; Region: Response_reg; pfam00072 869211001167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001168 active site 869211001169 phosphorylation site [posttranslational modification] 869211001170 intermolecular recognition site; other site 869211001171 dimerization interface [polypeptide binding]; other site 869211001172 Helix-turn-helix domain; Region: HTH_17; pfam12728 869211001173 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869211001174 active site 869211001175 phosphorylation site [posttranslational modification] 869211001176 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869211001177 active site 869211001178 phosphorylation site [posttranslational modification] 869211001179 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 869211001180 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 869211001181 FOG: CBS domain [General function prediction only]; Region: COG0517 869211001182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 869211001183 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211001184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211001185 Transposase; Region: HTH_Tnp_1; pfam01527 869211001186 putative transposase OrfB; Reviewed; Region: PHA02517 869211001187 HTH-like domain; Region: HTH_21; pfam13276 869211001188 Integrase core domain; Region: rve; pfam00665 869211001189 Integrase core domain; Region: rve_3; pfam13683 869211001190 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211001191 Predicted transcriptional regulator [Transcription]; Region: COG2378 869211001192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211001193 putative DNA binding site [nucleotide binding]; other site 869211001194 putative Zn2+ binding site [ion binding]; other site 869211001195 WYL domain; Region: WYL; pfam13280 869211001196 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 869211001197 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 869211001198 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 869211001199 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869211001200 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869211001201 HIGH motif; other site 869211001202 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869211001203 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869211001204 active site 869211001205 KMSKS motif; other site 869211001206 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869211001207 tRNA binding surface [nucleotide binding]; other site 869211001208 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001210 dimer interface [polypeptide binding]; other site 869211001211 conserved gate region; other site 869211001212 ABC-ATPase subunit interface; other site 869211001213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211001214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001215 dimer interface [polypeptide binding]; other site 869211001216 conserved gate region; other site 869211001217 putative PBP binding loops; other site 869211001218 ABC-ATPase subunit interface; other site 869211001219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211001220 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 869211001221 Helix-turn-helix domain; Region: HTH_18; pfam12833 869211001222 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 869211001223 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 869211001224 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 869211001225 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 869211001226 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 869211001227 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869211001228 NAD binding site [chemical binding]; other site 869211001229 homodimer interface [polypeptide binding]; other site 869211001230 active site 869211001231 substrate binding site [chemical binding]; other site 869211001232 tartrate dehydrogenase; Region: TTC; TIGR02089 869211001233 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 869211001234 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 869211001235 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869211001236 Melibiase; Region: Melibiase; pfam02065 869211001237 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 869211001238 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 869211001239 dimer interface [polypeptide binding]; other site 869211001240 active site 869211001241 galactokinase; Provisional; Region: PRK03817 869211001242 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869211001243 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869211001244 putative alpha-glucosidase; Provisional; Region: PRK10658 869211001245 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 869211001246 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 869211001247 active site 869211001248 homotrimer interface [polypeptide binding]; other site 869211001249 catalytic site [active] 869211001250 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 869211001251 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 869211001252 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869211001253 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 869211001254 PKC phosphorylation site [posttranslational modification]; other site 869211001255 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 869211001256 Cupin domain; Region: Cupin_2; pfam07883 869211001257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211001258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869211001259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211001260 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211001261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001262 dimer interface [polypeptide binding]; other site 869211001263 conserved gate region; other site 869211001264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869211001265 ABC-ATPase subunit interface; other site 869211001266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211001267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001268 dimer interface [polypeptide binding]; other site 869211001269 conserved gate region; other site 869211001270 ABC-ATPase subunit interface; other site 869211001271 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211001272 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211001273 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 869211001274 Ycf48-like protein; Provisional; Region: PRK13684 869211001275 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 869211001276 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211001277 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211001278 Cache domain; Region: Cache_1; pfam02743 869211001279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211001280 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211001281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211001282 dimer interface [polypeptide binding]; other site 869211001283 putative CheW interface [polypeptide binding]; other site 869211001284 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 869211001285 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 869211001286 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 869211001287 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 869211001288 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869211001289 NADP binding site [chemical binding]; other site 869211001290 homodimer interface [polypeptide binding]; other site 869211001291 active site 869211001292 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869211001293 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869211001294 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869211001295 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 869211001296 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 869211001297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 869211001298 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 869211001299 Transposase domain (DUF772); Region: DUF772; pfam05598 869211001300 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211001301 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869211001302 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 869211001303 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 869211001304 DctM-like transporters; Region: DctM; pfam06808 869211001305 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 869211001306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 869211001307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211001308 NAD(P) binding site [chemical binding]; other site 869211001309 active site 869211001310 Transcriptional regulators [Transcription]; Region: GntR; COG1802 869211001311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869211001312 DNA-binding site [nucleotide binding]; DNA binding site 869211001313 FCD domain; Region: FCD; pfam07729 869211001314 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 869211001315 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 869211001316 ligand binding site [chemical binding]; other site 869211001317 NAD binding site [chemical binding]; other site 869211001318 catalytic site [active] 869211001319 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869211001320 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869211001321 active site 869211001322 catalytic tetrad [active] 869211001323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869211001324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211001325 HEAT repeats; Region: HEAT_2; pfam13646 869211001326 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211001327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001328 dimer interface [polypeptide binding]; other site 869211001329 conserved gate region; other site 869211001330 putative PBP binding loops; other site 869211001331 ABC-ATPase subunit interface; other site 869211001332 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211001333 MULE transposase domain; Region: MULE; pfam10551 869211001334 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211001335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211001336 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 869211001337 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 869211001338 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869211001339 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869211001340 substrate binding site [chemical binding]; other site 869211001341 ATP binding site [chemical binding]; other site 869211001342 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 869211001343 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869211001344 active site 869211001345 intersubunit interface [polypeptide binding]; other site 869211001346 catalytic residue [active] 869211001347 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 869211001348 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 869211001349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211001350 binding surface 869211001351 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211001352 TPR motif; other site 869211001353 AAA domain; Region: AAA_17; pfam13207 869211001354 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869211001355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869211001356 RNA binding surface [nucleotide binding]; other site 869211001357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869211001358 active site 869211001359 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211001360 MULE transposase domain; Region: MULE; pfam10551 869211001361 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 869211001362 substrate binding site [chemical binding]; other site 869211001363 trimer interface [polypeptide binding]; other site 869211001364 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869211001365 Mn binding site [ion binding]; other site 869211001366 D-ribose pyranase; Provisional; Region: PRK11797 869211001367 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869211001368 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 869211001369 substrate binding site [chemical binding]; other site 869211001370 dimer interface [polypeptide binding]; other site 869211001371 ATP binding site [chemical binding]; other site 869211001372 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211001373 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 869211001374 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 869211001375 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869211001376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211001377 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869211001378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211001379 DNA binding residues [nucleotide binding] 869211001380 pyruvate phosphate dikinase; Provisional; Region: PRK09279 869211001381 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 869211001382 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869211001383 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869211001384 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 869211001385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869211001386 minor groove reading motif; other site 869211001387 helix-hairpin-helix signature motif; other site 869211001388 substrate binding pocket [chemical binding]; other site 869211001389 active site 869211001390 D-mannonate oxidoreductase; Provisional; Region: PRK08277 869211001391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211001392 NAD(P) binding site [chemical binding]; other site 869211001393 active site 869211001394 Glucuronate isomerase; Region: UxaC; pfam02614 869211001395 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 869211001396 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 869211001397 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 869211001398 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 869211001399 active site 869211001400 HIGH motif; other site 869211001401 KMSKS motif; other site 869211001402 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 869211001403 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 869211001404 active site 869211001405 PHP-associated; Region: PHP_C; pfam13263 869211001406 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869211001407 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 869211001408 putative substrate binding site [chemical binding]; other site 869211001409 putative ATP binding site [chemical binding]; other site 869211001410 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 869211001411 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869211001412 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869211001413 Walker A/P-loop; other site 869211001414 ATP binding site [chemical binding]; other site 869211001415 Q-loop/lid; other site 869211001416 ABC transporter signature motif; other site 869211001417 Walker B; other site 869211001418 D-loop; other site 869211001419 H-loop/switch region; other site 869211001420 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869211001421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211001422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869211001423 TM-ABC transporter signature motif; other site 869211001424 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 869211001425 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869211001426 putative ligand binding site [chemical binding]; other site 869211001427 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211001428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211001429 DNA binding site [nucleotide binding] 869211001430 domain linker motif; other site 869211001431 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211001432 dimerization interface [polypeptide binding]; other site 869211001433 ligand binding site [chemical binding]; other site 869211001434 L-fucose isomerase; Provisional; Region: fucI; PRK10991 869211001435 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 869211001436 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869211001437 trimer interface [polypeptide binding]; other site 869211001438 substrate binding site [chemical binding]; other site 869211001439 Mn binding site [ion binding]; other site 869211001440 PAS domain; Region: PAS; smart00091 869211001441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211001442 metal binding site [ion binding]; metal-binding site 869211001443 active site 869211001444 I-site; other site 869211001445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869211001446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001447 Response regulator receiver domain; Region: Response_reg; pfam00072 869211001448 active site 869211001449 phosphorylation site [posttranslational modification] 869211001450 intermolecular recognition site; other site 869211001451 dimerization interface [polypeptide binding]; other site 869211001452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211001453 PAS domain; Region: PAS_9; pfam13426 869211001454 putative active site [active] 869211001455 heme pocket [chemical binding]; other site 869211001456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211001457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211001458 metal binding site [ion binding]; metal-binding site 869211001459 active site 869211001460 I-site; other site 869211001461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869211001462 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 869211001463 Rubrerythrin [Energy production and conversion]; Region: COG1592 869211001464 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 869211001465 binuclear metal center [ion binding]; other site 869211001466 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 869211001467 iron binding site [ion binding]; other site 869211001468 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 869211001469 Rubredoxin; Region: Rubredoxin; pfam00301 869211001470 iron binding site [ion binding]; other site 869211001471 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869211001472 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869211001473 active site 869211001474 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 869211001475 Transposase domain (DUF772); Region: DUF772; pfam05598 869211001476 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211001477 Homeodomain-like domain; Region: HTH_23; pfam13384 869211001478 Winged helix-turn helix; Region: HTH_29; pfam13551 869211001479 Homeodomain-like domain; Region: HTH_32; pfam13565 869211001480 Integrase core domain; Region: rve; pfam00665 869211001481 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869211001482 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869211001483 active site 869211001484 HIGH motif; other site 869211001485 nucleotide binding site [chemical binding]; other site 869211001486 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869211001487 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869211001488 active site 869211001489 KMSKS motif; other site 869211001490 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869211001491 tRNA binding surface [nucleotide binding]; other site 869211001492 anticodon binding site; other site 869211001493 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869211001494 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869211001495 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869211001496 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869211001497 Fe2+ transport protein; Region: Iron_transport; pfam10634 869211001498 Predicted membrane protein [Function unknown]; Region: COG4393 869211001499 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 869211001500 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869211001501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211001502 FtsX-like permease family; Region: FtsX; pfam02687 869211001503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211001504 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211001505 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211001506 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869211001507 Walker A/P-loop; other site 869211001508 ATP binding site [chemical binding]; other site 869211001509 Q-loop/lid; other site 869211001510 ABC transporter signature motif; other site 869211001511 Walker B; other site 869211001512 D-loop; other site 869211001513 H-loop/switch region; other site 869211001514 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 869211001515 short chain dehydrogenase; Provisional; Region: PRK06197 869211001516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211001517 NAD(P) binding site [chemical binding]; other site 869211001518 active site 869211001519 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869211001520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211001521 NAD(P) binding site [chemical binding]; other site 869211001522 active site 869211001523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211001524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211001525 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 869211001526 Peptidase family M28; Region: Peptidase_M28; pfam04389 869211001527 metal binding site [ion binding]; metal-binding site 869211001528 Cyclophilin-like; Region: Cyclophil_like; cl17583 869211001529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211001530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211001531 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211001532 MULE transposase domain; Region: MULE; pfam10551 869211001533 Divergent PAP2 family; Region: DUF212; pfam02681 869211001534 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 869211001535 SLBB domain; Region: SLBB; pfam10531 869211001536 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869211001537 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 869211001538 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869211001539 catalytic motif [active] 869211001540 Zn binding site [ion binding]; other site 869211001541 RibD C-terminal domain; Region: RibD_C; cl17279 869211001542 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 869211001543 Lumazine binding domain; Region: Lum_binding; pfam00677 869211001544 Lumazine binding domain; Region: Lum_binding; pfam00677 869211001545 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 869211001546 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 869211001547 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869211001548 dimerization interface [polypeptide binding]; other site 869211001549 active site 869211001550 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869211001551 homopentamer interface [polypeptide binding]; other site 869211001552 active site 869211001553 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 869211001554 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 869211001555 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 869211001556 active site 869211001557 ATP binding site [chemical binding]; other site 869211001558 substrate binding site [chemical binding]; other site 869211001559 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869211001560 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869211001561 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869211001562 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211001563 MULE transposase domain; Region: MULE; pfam10551 869211001564 Transposase domain (DUF772); Region: DUF772; pfam05598 869211001565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211001566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211001567 Transposase; Region: HTH_Tnp_1; pfam01527 869211001568 putative transposase OrfB; Reviewed; Region: PHA02517 869211001569 HTH-like domain; Region: HTH_21; pfam13276 869211001570 Integrase core domain; Region: rve; pfam00665 869211001571 Integrase core domain; Region: rve_3; pfam13683 869211001572 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 869211001573 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 869211001574 catalytic domain interface [polypeptide binding]; other site 869211001575 homodimer interface [polypeptide binding]; other site 869211001576 putative active site [active] 869211001577 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869211001578 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869211001579 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 869211001580 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 869211001581 active site 869211001582 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869211001583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869211001584 nucleotide binding site [chemical binding]; other site 869211001585 Uncharacterized conserved protein [Function unknown]; Region: COG0432 869211001586 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 869211001587 putative active site [active] 869211001588 Zn binding site [ion binding]; other site 869211001589 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869211001590 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211001591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001592 dimer interface [polypeptide binding]; other site 869211001593 conserved gate region; other site 869211001594 putative PBP binding loops; other site 869211001595 ABC-ATPase subunit interface; other site 869211001596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211001597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001598 dimer interface [polypeptide binding]; other site 869211001599 conserved gate region; other site 869211001600 putative PBP binding loops; other site 869211001601 ABC-ATPase subunit interface; other site 869211001602 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 869211001603 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 869211001604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211001605 FeS/SAM binding site; other site 869211001606 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 869211001607 biotin synthase; Provisional; Region: PRK07094 869211001608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211001609 FeS/SAM binding site; other site 869211001610 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 869211001611 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 869211001612 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 869211001613 tetramer interface [polypeptide binding]; other site 869211001614 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 869211001615 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 869211001616 G1 box; other site 869211001617 GTP/Mg2+ binding site [chemical binding]; other site 869211001618 Switch I region; other site 869211001619 G2 box; other site 869211001620 Switch II region; other site 869211001621 G3 box; other site 869211001622 G4 box; other site 869211001623 G5 box; other site 869211001624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001625 conserved gate region; other site 869211001626 ABC-ATPase subunit interface; other site 869211001627 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 869211001628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211001629 Walker A/P-loop; other site 869211001630 ATP binding site [chemical binding]; other site 869211001631 Q-loop/lid; other site 869211001632 ABC transporter signature motif; other site 869211001633 Walker B; other site 869211001634 D-loop; other site 869211001635 H-loop/switch region; other site 869211001636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001637 dimer interface [polypeptide binding]; other site 869211001638 conserved gate region; other site 869211001639 putative PBP binding loops; other site 869211001640 ABC-ATPase subunit interface; other site 869211001641 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 869211001642 Predicted amidohydrolase [General function prediction only]; Region: COG0388 869211001643 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 869211001644 active site 869211001645 catalytic triad [active] 869211001646 dimer interface [polypeptide binding]; other site 869211001647 Transposase domain (DUF772); Region: DUF772; pfam05598 869211001648 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211001649 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 869211001650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869211001651 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869211001652 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 869211001653 putative dimer interface [polypeptide binding]; other site 869211001654 putative anticodon binding site; other site 869211001655 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869211001656 homodimer interface [polypeptide binding]; other site 869211001657 motif 1; other site 869211001658 motif 2; other site 869211001659 active site 869211001660 motif 3; other site 869211001661 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869211001662 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 869211001663 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 869211001664 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 869211001665 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869211001666 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 869211001667 putative active site [active] 869211001668 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211001669 MULE transposase domain; Region: MULE; pfam10551 869211001670 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 869211001671 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 869211001672 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 869211001673 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869211001674 putative homodimer interface [polypeptide binding]; other site 869211001675 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869211001676 heterodimer interface [polypeptide binding]; other site 869211001677 homodimer interface [polypeptide binding]; other site 869211001678 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869211001679 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869211001680 putative thiostrepton binding site; other site 869211001681 23S rRNA interface [nucleotide binding]; other site 869211001682 L7/L12 interface [polypeptide binding]; other site 869211001683 L25 interface [polypeptide binding]; other site 869211001684 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869211001685 mRNA/rRNA interface [nucleotide binding]; other site 869211001686 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869211001687 23S rRNA interface [nucleotide binding]; other site 869211001688 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869211001689 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869211001690 core dimer interface [polypeptide binding]; other site 869211001691 peripheral dimer interface [polypeptide binding]; other site 869211001692 L10 interface [polypeptide binding]; other site 869211001693 L11 interface [polypeptide binding]; other site 869211001694 putative EF-Tu interaction site [polypeptide binding]; other site 869211001695 putative EF-G interaction site [polypeptide binding]; other site 869211001696 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869211001697 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869211001698 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869211001699 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869211001700 RPB1 interaction site [polypeptide binding]; other site 869211001701 RPB10 interaction site [polypeptide binding]; other site 869211001702 RPB11 interaction site [polypeptide binding]; other site 869211001703 RPB3 interaction site [polypeptide binding]; other site 869211001704 RPB12 interaction site [polypeptide binding]; other site 869211001705 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 869211001706 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869211001707 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869211001708 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869211001709 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869211001710 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 869211001711 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 869211001712 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 869211001713 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211001714 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869211001715 DNA binding site [nucleotide binding] 869211001716 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869211001717 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869211001718 S17 interaction site [polypeptide binding]; other site 869211001719 S8 interaction site; other site 869211001720 16S rRNA interaction site [nucleotide binding]; other site 869211001721 streptomycin interaction site [chemical binding]; other site 869211001722 23S rRNA interaction site [nucleotide binding]; other site 869211001723 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869211001724 30S ribosomal protein S7; Validated; Region: PRK05302 869211001725 elongation factor Tu; Reviewed; Region: PRK00049 869211001726 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869211001727 G1 box; other site 869211001728 GEF interaction site [polypeptide binding]; other site 869211001729 GTP/Mg2+ binding site [chemical binding]; other site 869211001730 Switch I region; other site 869211001731 G2 box; other site 869211001732 G3 box; other site 869211001733 Switch II region; other site 869211001734 G4 box; other site 869211001735 G5 box; other site 869211001736 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869211001737 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869211001738 Antibiotic Binding Site [chemical binding]; other site 869211001739 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869211001740 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869211001741 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869211001742 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869211001743 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869211001744 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869211001745 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869211001746 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869211001747 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869211001748 putative translocon binding site; other site 869211001749 protein-rRNA interface [nucleotide binding]; other site 869211001750 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869211001751 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869211001752 G-X-X-G motif; other site 869211001753 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869211001754 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869211001755 23S rRNA interface [nucleotide binding]; other site 869211001756 5S rRNA interface [nucleotide binding]; other site 869211001757 putative antibiotic binding site [chemical binding]; other site 869211001758 L25 interface [polypeptide binding]; other site 869211001759 L27 interface [polypeptide binding]; other site 869211001760 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869211001761 23S rRNA interface [nucleotide binding]; other site 869211001762 putative translocon interaction site; other site 869211001763 signal recognition particle (SRP54) interaction site; other site 869211001764 L23 interface [polypeptide binding]; other site 869211001765 trigger factor interaction site; other site 869211001766 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869211001767 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869211001768 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869211001769 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869211001770 RNA binding site [nucleotide binding]; other site 869211001771 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869211001772 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869211001773 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869211001774 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 869211001775 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869211001776 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869211001777 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869211001778 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869211001779 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869211001780 5S rRNA interface [nucleotide binding]; other site 869211001781 23S rRNA interface [nucleotide binding]; other site 869211001782 L5 interface [polypeptide binding]; other site 869211001783 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 869211001784 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869211001785 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869211001786 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869211001787 23S rRNA binding site [nucleotide binding]; other site 869211001788 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869211001789 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869211001790 SecY translocase; Region: SecY; pfam00344 869211001791 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 869211001792 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 869211001793 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869211001794 30S ribosomal protein S11; Validated; Region: PRK05309 869211001795 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869211001796 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869211001797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869211001798 RNA binding surface [nucleotide binding]; other site 869211001799 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869211001800 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869211001801 alphaNTD homodimer interface [polypeptide binding]; other site 869211001802 alphaNTD - beta interaction site [polypeptide binding]; other site 869211001803 alphaNTD - beta' interaction site [polypeptide binding]; other site 869211001804 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869211001805 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869211001806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211001807 S-adenosylmethionine binding site [chemical binding]; other site 869211001808 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 869211001809 RNA/DNA hybrid binding site [nucleotide binding]; other site 869211001810 active site 869211001811 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 869211001812 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869211001813 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 869211001814 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 869211001815 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869211001816 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869211001817 protein binding site [polypeptide binding]; other site 869211001818 excinuclease ABC subunit B; Provisional; Region: PRK05298 869211001819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211001820 ATP binding site [chemical binding]; other site 869211001821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869211001822 nucleotide binding region [chemical binding]; other site 869211001823 ATP-binding site [chemical binding]; other site 869211001824 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869211001825 UvrB/uvrC motif; Region: UVR; pfam02151 869211001826 Bacterial SH3 domain; Region: SH3_3; cl17532 869211001827 PBP superfamily domain; Region: PBP_like_2; cl17296 869211001828 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 869211001829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001830 dimer interface [polypeptide binding]; other site 869211001831 conserved gate region; other site 869211001832 putative PBP binding loops; other site 869211001833 ABC-ATPase subunit interface; other site 869211001834 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869211001835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211001836 dimer interface [polypeptide binding]; other site 869211001837 conserved gate region; other site 869211001838 putative PBP binding loops; other site 869211001839 ABC-ATPase subunit interface; other site 869211001840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869211001841 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 869211001842 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869211001843 Walker A/P-loop; other site 869211001844 ATP binding site [chemical binding]; other site 869211001845 Q-loop/lid; other site 869211001846 ABC transporter signature motif; other site 869211001847 Walker B; other site 869211001848 D-loop; other site 869211001849 H-loop/switch region; other site 869211001850 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869211001851 active site 869211001852 metal binding site [ion binding]; metal-binding site 869211001853 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 869211001854 Ca binding site [ion binding]; other site 869211001855 ligand binding site I [chemical binding]; other site 869211001856 homodimer interface [polypeptide binding]; other site 869211001857 ligand binding site II [chemical binding]; other site 869211001858 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 869211001859 substrate binding pocket [chemical binding]; other site 869211001860 catalytic residues [active] 869211001861 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869211001862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211001863 putative active site [active] 869211001864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211001865 dimer interface [polypeptide binding]; other site 869211001866 phosphorylation site [posttranslational modification] 869211001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211001868 ATP binding site [chemical binding]; other site 869211001869 Mg2+ binding site [ion binding]; other site 869211001870 G-X-G motif; other site 869211001871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869211001872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001873 active site 869211001874 phosphorylation site [posttranslational modification] 869211001875 intermolecular recognition site; other site 869211001876 dimerization interface [polypeptide binding]; other site 869211001877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869211001878 DNA binding site [nucleotide binding] 869211001879 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869211001880 PhoU domain; Region: PhoU; pfam01895 869211001881 PhoU domain; Region: PhoU; pfam01895 869211001882 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 869211001883 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869211001884 active site 869211001885 homodimer interface [polypeptide binding]; other site 869211001886 Colicin V production protein; Region: Colicin_V; pfam02674 869211001887 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869211001888 PAS domain; Region: PAS; smart00091 869211001889 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 869211001890 putative active site [active] 869211001891 heme pocket [chemical binding]; other site 869211001892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211001893 dimer interface [polypeptide binding]; other site 869211001894 phosphorylation site [posttranslational modification] 869211001895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211001896 ATP binding site [chemical binding]; other site 869211001897 Mg2+ binding site [ion binding]; other site 869211001898 G-X-G motif; other site 869211001899 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869211001900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001901 active site 869211001902 phosphorylation site [posttranslational modification] 869211001903 intermolecular recognition site; other site 869211001904 dimerization interface [polypeptide binding]; other site 869211001905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211001906 Walker A motif; other site 869211001907 ATP binding site [chemical binding]; other site 869211001908 Walker B motif; other site 869211001909 arginine finger; other site 869211001910 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869211001911 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869211001912 HSP70 interaction site [polypeptide binding]; other site 869211001913 aspartate kinase III; Validated; Region: PRK09084 869211001914 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 869211001915 putative catalytic residues [active] 869211001916 nucleotide binding site [chemical binding]; other site 869211001917 aspartate binding site [chemical binding]; other site 869211001918 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 869211001919 dimer interface [polypeptide binding]; other site 869211001920 allosteric regulatory binding pocket; other site 869211001921 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 869211001922 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 869211001923 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 869211001924 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 869211001925 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869211001926 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869211001927 oligomerisation interface [polypeptide binding]; other site 869211001928 mobile loop; other site 869211001929 roof hairpin; other site 869211001930 Transposase domain (DUF772); Region: DUF772; pfam05598 869211001931 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211001932 GTPase Era; Reviewed; Region: era; PRK00089 869211001933 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869211001934 G1 box; other site 869211001935 GTP/Mg2+ binding site [chemical binding]; other site 869211001936 Switch I region; other site 869211001937 G2 box; other site 869211001938 Switch II region; other site 869211001939 G3 box; other site 869211001940 G4 box; other site 869211001941 G5 box; other site 869211001942 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 869211001943 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869211001944 oligomer interface [polypeptide binding]; other site 869211001945 active site residues [active] 869211001946 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869211001947 putative catalytic site [active] 869211001948 putative metal binding site [ion binding]; other site 869211001949 putative phosphate binding site [ion binding]; other site 869211001950 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 869211001951 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 869211001952 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 869211001953 putative ligand binding site [chemical binding]; other site 869211001954 putative NAD binding site [chemical binding]; other site 869211001955 catalytic site [active] 869211001956 mannonate dehydratase; Provisional; Region: PRK03906 869211001957 mannonate dehydratase; Region: uxuA; TIGR00695 869211001958 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211001959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211001960 metal binding site [ion binding]; metal-binding site 869211001961 active site 869211001962 I-site; other site 869211001963 Response regulator receiver domain; Region: Response_reg; pfam00072 869211001964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001965 active site 869211001966 phosphorylation site [posttranslational modification] 869211001967 intermolecular recognition site; other site 869211001968 dimerization interface [polypeptide binding]; other site 869211001969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211001970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211001971 ATP binding site [chemical binding]; other site 869211001972 G-X-G motif; other site 869211001973 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 869211001974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211001975 putative active site [active] 869211001976 heme pocket [chemical binding]; other site 869211001977 PAS fold; Region: PAS_4; pfam08448 869211001978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211001979 PAS domain; Region: PAS_9; pfam13426 869211001980 putative active site [active] 869211001981 heme pocket [chemical binding]; other site 869211001982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211001983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211001984 dimer interface [polypeptide binding]; other site 869211001985 phosphorylation site [posttranslational modification] 869211001986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211001987 ATP binding site [chemical binding]; other site 869211001988 Mg2+ binding site [ion binding]; other site 869211001989 G-X-G motif; other site 869211001990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211001992 active site 869211001993 phosphorylation site [posttranslational modification] 869211001994 intermolecular recognition site; other site 869211001995 dimerization interface [polypeptide binding]; other site 869211001996 arginine decarboxylase; Provisional; Region: PRK05354 869211001997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 869211001998 dimer interface [polypeptide binding]; other site 869211001999 active site 869211002000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869211002001 catalytic residues [active] 869211002002 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 869211002003 Chromate transporter; Region: Chromate_transp; pfam02417 869211002004 Chromate transporter; Region: Chromate_transp; pfam02417 869211002005 Transcriptional regulator; Region: Rrf2; pfam02082 869211002006 Predicted transcriptional regulator [Transcription]; Region: COG1959 869211002007 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869211002008 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869211002009 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869211002010 Walker A/P-loop; other site 869211002011 ATP binding site [chemical binding]; other site 869211002012 Q-loop/lid; other site 869211002013 ABC transporter signature motif; other site 869211002014 Walker B; other site 869211002015 D-loop; other site 869211002016 H-loop/switch region; other site 869211002017 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869211002018 FeS assembly protein SufB; Region: sufB; TIGR01980 869211002019 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869211002020 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 869211002021 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 869211002022 [2Fe-2S] cluster binding site [ion binding]; other site 869211002023 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869211002024 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869211002025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869211002026 catalytic residue [active] 869211002027 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869211002028 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869211002029 trimerization site [polypeptide binding]; other site 869211002030 active site 869211002031 DHH family; Region: DHH; pfam01368 869211002032 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 869211002033 C factor cell-cell signaling protein; Provisional; Region: PRK09009 869211002034 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 869211002035 NADP binding site [chemical binding]; other site 869211002036 homodimer interface [polypeptide binding]; other site 869211002037 active site 869211002038 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 869211002039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211002040 Walker A motif; other site 869211002041 ATP binding site [chemical binding]; other site 869211002042 Walker B motif; other site 869211002043 arginine finger; other site 869211002044 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 869211002045 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869211002046 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869211002047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211002048 Walker A motif; other site 869211002049 ATP binding site [chemical binding]; other site 869211002050 Walker B motif; other site 869211002051 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869211002052 Clp protease; Region: CLP_protease; pfam00574 869211002053 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869211002054 oligomer interface [polypeptide binding]; other site 869211002055 active site residues [active] 869211002056 trigger factor; Provisional; Region: tig; PRK01490 869211002057 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869211002058 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869211002059 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 869211002060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211002061 Walker A motif; other site 869211002062 ATP binding site [chemical binding]; other site 869211002063 Walker B motif; other site 869211002064 arginine finger; other site 869211002065 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869211002066 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869211002067 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869211002068 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869211002069 PhoU domain; Region: PhoU; pfam01895 869211002070 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211002071 MULE transposase domain; Region: MULE; pfam10551 869211002072 ornithine carbamoyltransferase; Validated; Region: PRK02102 869211002073 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869211002074 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869211002075 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869211002076 alanine racemase; Reviewed; Region: alr; PRK00053 869211002077 active site 869211002078 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869211002079 dimer interface [polypeptide binding]; other site 869211002080 substrate binding site [chemical binding]; other site 869211002081 catalytic residues [active] 869211002082 Transcriptional regulators [Transcription]; Region: GntR; COG1802 869211002083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869211002084 DNA-binding site [nucleotide binding]; DNA binding site 869211002085 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869211002086 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869211002087 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869211002088 Tetramer interface [polypeptide binding]; other site 869211002089 active site 869211002090 FMN-binding site [chemical binding]; other site 869211002091 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 869211002092 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869211002093 ADP binding site [chemical binding]; other site 869211002094 magnesium binding site [ion binding]; other site 869211002095 putative shikimate binding site; other site 869211002096 Clostripain family; Region: Peptidase_C11; pfam03415 869211002097 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869211002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211002099 S-adenosylmethionine binding site [chemical binding]; other site 869211002100 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 869211002101 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869211002102 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869211002103 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 869211002104 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 869211002105 transmembrane helices; other site 869211002106 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 869211002107 putative oxidoreductase; Provisional; Region: PRK10083 869211002108 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 869211002109 putative NAD(P) binding site [chemical binding]; other site 869211002110 catalytic Zn binding site [ion binding]; other site 869211002111 structural Zn binding site [ion binding]; other site 869211002112 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 869211002113 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 869211002114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869211002115 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869211002116 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869211002117 Walker A/P-loop; other site 869211002118 ATP binding site [chemical binding]; other site 869211002119 Q-loop/lid; other site 869211002120 ABC transporter signature motif; other site 869211002121 Walker B; other site 869211002122 D-loop; other site 869211002123 H-loop/switch region; other site 869211002124 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869211002125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869211002126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211002127 Walker A/P-loop; other site 869211002128 ATP binding site [chemical binding]; other site 869211002129 Q-loop/lid; other site 869211002130 ABC transporter signature motif; other site 869211002131 Walker B; other site 869211002132 D-loop; other site 869211002133 H-loop/switch region; other site 869211002134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869211002135 MarR family; Region: MarR; pfam01047 869211002136 MarR family; Region: MarR_2; cl17246 869211002137 Predicted transcriptional regulators [Transcription]; Region: COG1695 869211002138 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869211002139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211002140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869211002141 Cupin domain; Region: Cupin_2; cl17218 869211002142 Uncharacterized conserved protein [Function unknown]; Region: COG2461 869211002143 Family of unknown function (DUF438); Region: DUF438; pfam04282 869211002144 Hemerythrin-like domain; Region: Hr-like; cd12108 869211002145 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 869211002146 trimer interface [polypeptide binding]; other site 869211002147 putative Zn binding site [ion binding]; other site 869211002148 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869211002149 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 869211002150 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869211002151 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869211002152 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 869211002153 active site 869211002154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 869211002155 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 869211002156 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 869211002157 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869211002158 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869211002159 NAD(P) binding site [chemical binding]; other site 869211002160 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869211002161 Transcriptional regulators [Transcription]; Region: FadR; COG2186 869211002162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869211002163 DNA-binding site [nucleotide binding]; DNA binding site 869211002164 FCD domain; Region: FCD; pfam07729 869211002165 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 869211002166 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 869211002167 intersubunit interface [polypeptide binding]; other site 869211002168 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869211002169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211002170 Walker A/P-loop; other site 869211002171 ATP binding site [chemical binding]; other site 869211002172 Q-loop/lid; other site 869211002173 ABC transporter signature motif; other site 869211002174 Walker B; other site 869211002175 D-loop; other site 869211002176 H-loop/switch region; other site 869211002177 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869211002178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 869211002179 ABC-ATPase subunit interface; other site 869211002180 dimer interface [polypeptide binding]; other site 869211002181 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 869211002182 Malic enzyme, N-terminal domain; Region: malic; pfam00390 869211002183 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 869211002184 putative NAD(P) binding site [chemical binding]; other site 869211002185 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 869211002186 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 869211002187 putative dimer interface [polypeptide binding]; other site 869211002188 [2Fe-2S] cluster binding site [ion binding]; other site 869211002189 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 869211002190 SLBB domain; Region: SLBB; pfam10531 869211002191 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 869211002192 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869211002193 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 869211002194 catalytic loop [active] 869211002195 iron binding site [ion binding]; other site 869211002196 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 869211002197 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 869211002198 4Fe-4S binding domain; Region: Fer4; pfam00037 869211002199 4Fe-4S binding domain; Region: Fer4; pfam00037 869211002200 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 869211002201 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 869211002202 FeoA domain; Region: FeoA; pfam04023 869211002203 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 869211002204 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869211002205 G1 box; other site 869211002206 GTP/Mg2+ binding site [chemical binding]; other site 869211002207 G2 box; other site 869211002208 Switch I region; other site 869211002209 G3 box; other site 869211002210 Switch II region; other site 869211002211 G4 box; other site 869211002212 G5 box; other site 869211002213 Nucleoside recognition; Region: Gate; pfam07670 869211002214 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 869211002215 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 869211002216 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 869211002217 non-specific DNA interactions [nucleotide binding]; other site 869211002218 DNA binding site [nucleotide binding] 869211002219 sequence specific DNA binding site [nucleotide binding]; other site 869211002220 putative cAMP binding site [chemical binding]; other site 869211002221 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869211002222 Ion channel; Region: Ion_trans_2; pfam07885 869211002223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869211002224 ligand binding site [chemical binding]; other site 869211002225 flexible hinge region; other site 869211002226 intracellular protease, PfpI family; Region: PfpI; TIGR01382 869211002227 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869211002228 conserved cys residue [active] 869211002229 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 869211002230 MgtE intracellular N domain; Region: MgtE_N; smart00924 869211002231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 869211002232 Divalent cation transporter; Region: MgtE; pfam01769 869211002233 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 869211002234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211002235 active site 869211002236 Glucokinase; Region: Glucokinase; pfam02685 869211002237 glucokinase, proteobacterial type; Region: glk; TIGR00749 869211002238 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 869211002239 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 869211002240 trimer interface [polypeptide binding]; other site 869211002241 putative metal binding site [ion binding]; other site 869211002242 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 869211002243 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 869211002244 P loop; other site 869211002245 Nucleotide binding site [chemical binding]; other site 869211002246 DTAP/Switch II; other site 869211002247 Switch I; other site 869211002248 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211002249 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211002250 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211002251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002252 dimer interface [polypeptide binding]; other site 869211002253 conserved gate region; other site 869211002254 putative PBP binding loops; other site 869211002255 ABC-ATPase subunit interface; other site 869211002256 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869211002257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002258 dimer interface [polypeptide binding]; other site 869211002259 conserved gate region; other site 869211002260 putative PBP binding loops; other site 869211002261 ABC-ATPase subunit interface; other site 869211002262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211002263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211002264 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 869211002265 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 869211002266 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 869211002267 active site 869211002268 FMN binding site [chemical binding]; other site 869211002269 substrate binding site [chemical binding]; other site 869211002270 3Fe-4S cluster binding site [ion binding]; other site 869211002271 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869211002272 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 869211002273 NodB motif; other site 869211002274 active site 869211002275 catalytic site [active] 869211002276 AzlC protein; Region: AzlC; cl00570 869211002277 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 869211002278 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 869211002279 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869211002280 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869211002281 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 869211002282 DHH family; Region: DHH; pfam01368 869211002283 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869211002284 DHHA1 domain; Region: DHHA1; pfam02272 869211002285 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869211002286 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211002287 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869211002288 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869211002289 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 869211002290 active site 869211002291 dimerization interface [polypeptide binding]; other site 869211002292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869211002293 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869211002294 active site 869211002295 metal binding site [ion binding]; metal-binding site 869211002296 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 869211002297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002298 binding surface 869211002299 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211002300 TPR motif; other site 869211002301 TPR repeat; Region: TPR_11; pfam13414 869211002302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002303 binding surface 869211002304 TPR motif; other site 869211002305 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869211002306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002307 binding surface 869211002308 TPR motif; other site 869211002309 TPR repeat; Region: TPR_11; pfam13414 869211002310 Restriction endonuclease; Region: Mrr_cat; pfam04471 869211002311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002312 binding surface 869211002313 TPR motif; other site 869211002314 TPR repeat; Region: TPR_11; pfam13414 869211002315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002316 binding surface 869211002317 TPR motif; other site 869211002318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002319 binding surface 869211002320 TPR motif; other site 869211002321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869211002322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002323 binding surface 869211002324 TPR repeat; Region: TPR_11; pfam13414 869211002325 TPR motif; other site 869211002326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002327 binding surface 869211002328 TPR repeat; Region: TPR_11; pfam13414 869211002329 TPR motif; other site 869211002330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869211002331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002332 binding surface 869211002333 TPR motif; other site 869211002334 TPR repeat; Region: TPR_11; pfam13414 869211002335 TPR repeat; Region: TPR_11; pfam13414 869211002336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211002337 binding surface 869211002338 TPR motif; other site 869211002339 TPR repeat; Region: TPR_11; pfam13414 869211002340 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869211002341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211002342 ATP binding site [chemical binding]; other site 869211002343 Mg2+ binding site [ion binding]; other site 869211002344 G-X-G motif; other site 869211002345 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 869211002346 ATP binding site [chemical binding]; other site 869211002347 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869211002348 FecR protein; Region: FecR; pfam04773 869211002349 Protein of unknown function (DUF503); Region: DUF503; pfam04456 869211002350 Late competence development protein ComFB; Region: ComFB; pfam10719 869211002351 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 869211002352 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 869211002353 Ligand Binding Site [chemical binding]; other site 869211002354 TIGR00269 family protein; Region: TIGR00269 869211002355 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 869211002356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211002357 Zn2+ binding site [ion binding]; other site 869211002358 Mg2+ binding site [ion binding]; other site 869211002359 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869211002360 active site 869211002361 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869211002362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211002363 ATP binding site [chemical binding]; other site 869211002364 putative Mg++ binding site [ion binding]; other site 869211002365 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869211002366 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 869211002367 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869211002368 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 869211002369 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 869211002370 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 869211002371 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 869211002372 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 869211002373 CAAX protease self-immunity; Region: Abi; pfam02517 869211002374 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 869211002375 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869211002376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869211002377 Walker A/P-loop; other site 869211002378 ATP binding site [chemical binding]; other site 869211002379 Q-loop/lid; other site 869211002380 ABC transporter signature motif; other site 869211002381 Walker B; other site 869211002382 D-loop; other site 869211002383 H-loop/switch region; other site 869211002384 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869211002385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211002386 DNA binding residues [nucleotide binding] 869211002387 PAS domain; Region: PAS_9; pfam13426 869211002388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211002389 putative active site [active] 869211002390 heme pocket [chemical binding]; other site 869211002391 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 869211002392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211002393 Walker A motif; other site 869211002394 ATP binding site [chemical binding]; other site 869211002395 Walker B motif; other site 869211002396 arginine finger; other site 869211002397 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869211002398 DNA-binding interface [nucleotide binding]; DNA binding site 869211002399 Uncharacterized conserved protein [Function unknown]; Region: COG1433 869211002400 Prefoldin subunit; Region: Prefoldin_2; pfam01920 869211002401 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 869211002402 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 869211002403 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 869211002404 EamA-like transporter family; Region: EamA; pfam00892 869211002405 EamA-like transporter family; Region: EamA; pfam00892 869211002406 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 869211002407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869211002408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869211002409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869211002410 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 869211002411 active site residue [active] 869211002412 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 869211002413 CPxP motif; other site 869211002414 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 869211002415 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 869211002416 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 869211002417 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 869211002418 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 869211002419 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 869211002420 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 869211002421 dimer interface [polypeptide binding]; other site 869211002422 active site 869211002423 metal binding site [ion binding]; metal-binding site 869211002424 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 869211002425 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211002426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211002427 DNA binding site [nucleotide binding] 869211002428 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211002429 ligand binding site [chemical binding]; other site 869211002430 dimerization interface [polypeptide binding]; other site 869211002431 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211002432 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211002433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002434 conserved gate region; other site 869211002435 dimer interface [polypeptide binding]; other site 869211002436 putative PBP binding loops; other site 869211002437 ABC-ATPase subunit interface; other site 869211002438 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211002439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002440 dimer interface [polypeptide binding]; other site 869211002441 conserved gate region; other site 869211002442 putative PBP binding loops; other site 869211002443 ABC-ATPase subunit interface; other site 869211002444 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869211002445 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869211002446 Ca binding site [ion binding]; other site 869211002447 active site 869211002448 catalytic site [active] 869211002449 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 869211002450 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869211002451 metal-binding site [ion binding] 869211002452 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 869211002453 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869211002454 metal-binding site [ion binding] 869211002455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869211002456 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869211002457 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869211002458 metal-binding site [ion binding] 869211002459 Short C-terminal domain; Region: SHOCT; pfam09851 869211002460 Domain of unknown function DUF302; Region: DUF302; pfam03625 869211002461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211002462 S-adenosylmethionine binding site [chemical binding]; other site 869211002463 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 869211002464 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 869211002465 lipoyl attachment site [posttranslational modification]; other site 869211002466 DsrH like protein; Region: DsrH; cl17347 869211002467 DsrE/DsrF-like family; Region: DrsE; cl00672 869211002468 DsrE/DsrF-like family; Region: DrsE; cl00672 869211002469 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 869211002470 Sulphur transport; Region: Sulf_transp; pfam04143 869211002471 Sulphur transport; Region: Sulf_transp; pfam04143 869211002472 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 869211002473 CPxP motif; other site 869211002474 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 869211002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869211002476 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869211002477 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 869211002478 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 869211002479 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 869211002480 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 869211002481 DXD motif; other site 869211002482 Response regulator receiver domain; Region: Response_reg; pfam00072 869211002483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211002484 active site 869211002485 phosphorylation site [posttranslational modification] 869211002486 intermolecular recognition site; other site 869211002487 dimerization interface [polypeptide binding]; other site 869211002488 GTPase RsgA; Reviewed; Region: PRK01889 869211002489 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 869211002490 RNA binding site [nucleotide binding]; other site 869211002491 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869211002492 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869211002493 GTP/Mg2+ binding site [chemical binding]; other site 869211002494 G4 box; other site 869211002495 G5 box; other site 869211002496 G1 box; other site 869211002497 Switch I region; other site 869211002498 G2 box; other site 869211002499 G3 box; other site 869211002500 Switch II region; other site 869211002501 LysE type translocator; Region: LysE; cl00565 869211002502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 869211002503 Septum formation initiator; Region: DivIC; pfam04977 869211002504 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 869211002505 Uncharacterized conserved protein [Function unknown]; Region: COG4198 869211002506 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 869211002507 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 869211002508 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 869211002509 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 869211002510 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 869211002511 active site 869211002512 metal binding site [ion binding]; metal-binding site 869211002513 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 869211002514 substrate binding site [chemical binding]; other site 869211002515 active site 869211002516 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869211002517 active site 869211002518 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211002519 MULE transposase domain; Region: MULE; pfam10551 869211002520 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 869211002521 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 869211002522 intermolecular salt bridges; other site 869211002523 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211002524 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211002525 Predicted transcriptional regulator [Transcription]; Region: COG4189 869211002526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211002527 dimerization interface [polypeptide binding]; other site 869211002528 putative DNA binding site [nucleotide binding]; other site 869211002529 putative Zn2+ binding site [ion binding]; other site 869211002530 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869211002531 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 869211002532 substrate binding site [chemical binding]; other site 869211002533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869211002534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002535 dimer interface [polypeptide binding]; other site 869211002536 conserved gate region; other site 869211002537 putative PBP binding loops; other site 869211002538 ABC-ATPase subunit interface; other site 869211002539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869211002540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002541 dimer interface [polypeptide binding]; other site 869211002542 conserved gate region; other site 869211002543 putative PBP binding loops; other site 869211002544 ABC-ATPase subunit interface; other site 869211002545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869211002546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869211002547 Walker A/P-loop; other site 869211002548 ATP binding site [chemical binding]; other site 869211002549 Q-loop/lid; other site 869211002550 ABC transporter signature motif; other site 869211002551 Walker B; other site 869211002552 D-loop; other site 869211002553 H-loop/switch region; other site 869211002554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869211002555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869211002556 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869211002557 Walker A/P-loop; other site 869211002558 ATP binding site [chemical binding]; other site 869211002559 Q-loop/lid; other site 869211002560 ABC transporter signature motif; other site 869211002561 Walker B; other site 869211002562 D-loop; other site 869211002563 H-loop/switch region; other site 869211002564 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869211002565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211002566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869211002567 putative substrate translocation pore; other site 869211002568 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 869211002569 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869211002570 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 869211002571 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 869211002572 Cupin domain; Region: Cupin_2; cl17218 869211002573 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 869211002574 Transcriptional regulator; Region: Rrf2; cl17282 869211002575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211002576 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 869211002577 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 869211002578 Predicted peptidase [General function prediction only]; Region: COG4099 869211002579 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 869211002580 Probable beta-xylosidase; Provisional; Region: PLN03080 869211002581 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869211002582 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 869211002583 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 869211002584 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 869211002585 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869211002586 active site 869211002587 catalytic motif [active] 869211002588 Zn binding site [ion binding]; other site 869211002589 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 869211002590 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869211002591 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869211002592 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 869211002593 TrkA-N domain; Region: TrkA_N; pfam02254 869211002594 TrkA-C domain; Region: TrkA_C; pfam02080 869211002595 TrkA-N domain; Region: TrkA_N; pfam02254 869211002596 TrkA-C domain; Region: TrkA_C; pfam02080 869211002597 Domain of unknown function (DUF303); Region: DUF303; pfam03629 869211002598 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 869211002599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211002600 dimerization interface [polypeptide binding]; other site 869211002601 putative DNA binding site [nucleotide binding]; other site 869211002602 putative Zn2+ binding site [ion binding]; other site 869211002603 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 869211002604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869211002605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869211002606 Cobalt transport protein; Region: CbiQ; cl00463 869211002607 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869211002608 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869211002609 Walker A/P-loop; other site 869211002610 ATP binding site [chemical binding]; other site 869211002611 Q-loop/lid; other site 869211002612 ABC transporter signature motif; other site 869211002613 Walker B; other site 869211002614 D-loop; other site 869211002615 H-loop/switch region; other site 869211002616 BioY family; Region: BioY; pfam02632 869211002617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211002618 putative DNA binding site [nucleotide binding]; other site 869211002619 putative Zn2+ binding site [ion binding]; other site 869211002620 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 869211002621 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869211002622 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 869211002623 Uncharacterized conserved protein [Function unknown]; Region: COG5276 869211002624 LVIVD repeat; Region: LVIVD; pfam08309 869211002625 LVIVD repeat; Region: LVIVD; pfam08309 869211002626 LVIVD repeat; Region: LVIVD; pfam08309 869211002627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211002628 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 869211002629 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869211002630 Membrane transport protein; Region: Mem_trans; cl09117 869211002631 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 869211002632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211002633 Zn2+ binding site [ion binding]; other site 869211002634 Mg2+ binding site [ion binding]; other site 869211002635 aminotransferase AlaT; Validated; Region: PRK09265 869211002636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869211002637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211002638 homodimer interface [polypeptide binding]; other site 869211002639 catalytic residue [active] 869211002640 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869211002641 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869211002642 HIGH motif; other site 869211002643 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869211002644 active site 869211002645 KMSKS motif; other site 869211002646 glycyl-tRNA synthetase; Provisional; Region: PRK04173 869211002647 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 869211002648 dimer interface [polypeptide binding]; other site 869211002649 motif 1; other site 869211002650 active site 869211002651 motif 2; other site 869211002652 motif 3; other site 869211002653 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 869211002654 anticodon binding site; other site 869211002655 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869211002656 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869211002657 active site 869211002658 HIGH motif; other site 869211002659 dimer interface [polypeptide binding]; other site 869211002660 KMSKS motif; other site 869211002661 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869211002662 RNA binding surface [nucleotide binding]; other site 869211002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211002664 putative PBP binding loops; other site 869211002665 ABC-ATPase subunit interface; other site 869211002666 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869211002667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211002668 Walker A/P-loop; other site 869211002669 ATP binding site [chemical binding]; other site 869211002670 Q-loop/lid; other site 869211002671 ABC transporter signature motif; other site 869211002672 Walker B; other site 869211002673 D-loop; other site 869211002674 H-loop/switch region; other site 869211002675 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 869211002676 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 869211002677 CoA binding domain; Region: CoA_binding; pfam02629 869211002678 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869211002679 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869211002680 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869211002681 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869211002682 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869211002683 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 869211002684 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869211002685 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869211002686 active site 869211002687 HIGH motif; other site 869211002688 dimer interface [polypeptide binding]; other site 869211002689 KMSKS motif; other site 869211002690 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 869211002691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211002692 motif II; other site 869211002693 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869211002694 endonuclease III; Region: ENDO3c; smart00478 869211002695 minor groove reading motif; other site 869211002696 helix-hairpin-helix signature motif; other site 869211002697 substrate binding pocket [chemical binding]; other site 869211002698 active site 869211002699 TspO/MBR family; Region: TspO_MBR; pfam03073 869211002700 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 869211002701 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869211002702 active site 869211002703 substrate binding site [chemical binding]; other site 869211002704 metal binding site [ion binding]; metal-binding site 869211002705 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 869211002706 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 869211002707 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 869211002708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211002709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211002710 Response regulator receiver domain; Region: Response_reg; pfam00072 869211002711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211002712 active site 869211002713 phosphorylation site [posttranslational modification] 869211002714 intermolecular recognition site; other site 869211002715 dimerization interface [polypeptide binding]; other site 869211002716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211002717 Response regulator receiver domain; Region: Response_reg; pfam00072 869211002718 active site 869211002719 phosphorylation site [posttranslational modification] 869211002720 intermolecular recognition site; other site 869211002721 dimerization interface [polypeptide binding]; other site 869211002722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211002723 putative active site [active] 869211002724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211002725 heme pocket [chemical binding]; other site 869211002726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211002727 dimer interface [polypeptide binding]; other site 869211002728 phosphorylation site [posttranslational modification] 869211002729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211002730 ATP binding site [chemical binding]; other site 869211002731 Mg2+ binding site [ion binding]; other site 869211002732 G-X-G motif; other site 869211002733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211002734 Response regulator receiver domain; Region: Response_reg; pfam00072 869211002735 active site 869211002736 phosphorylation site [posttranslational modification] 869211002737 intermolecular recognition site; other site 869211002738 dimerization interface [polypeptide binding]; other site 869211002739 Response regulator receiver domain; Region: Response_reg; pfam00072 869211002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211002741 active site 869211002742 phosphorylation site [posttranslational modification] 869211002743 intermolecular recognition site; other site 869211002744 dimerization interface [polypeptide binding]; other site 869211002745 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869211002746 putative binding surface; other site 869211002747 active site 869211002748 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 869211002749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869211002750 ATP binding site [chemical binding]; other site 869211002751 putative Mg++ binding site [ion binding]; other site 869211002752 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211002753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211002754 active site 869211002755 phosphorylation site [posttranslational modification] 869211002756 intermolecular recognition site; other site 869211002757 dimerization interface [polypeptide binding]; other site 869211002758 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211002759 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211002760 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211002761 MULE transposase domain; Region: MULE; pfam10551 869211002762 argininosuccinate lyase; Provisional; Region: PRK00855 869211002763 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 869211002764 active sites [active] 869211002765 tetramer interface [polypeptide binding]; other site 869211002766 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869211002767 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 869211002768 oligomer interface [polypeptide binding]; other site 869211002769 metal binding site [ion binding]; metal-binding site 869211002770 metal binding site [ion binding]; metal-binding site 869211002771 Cl binding site [ion binding]; other site 869211002772 aspartate ring; other site 869211002773 basic sphincter; other site 869211002774 putative hydrophobic gate; other site 869211002775 periplasmic entrance; other site 869211002776 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 869211002777 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869211002778 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211002779 MULE transposase domain; Region: MULE; pfam10551 869211002780 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 869211002781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869211002782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869211002783 active site 869211002784 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 869211002785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211002786 nucleotide binding site [chemical binding]; other site 869211002787 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 869211002788 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 869211002789 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 869211002790 metal binding triad; other site 869211002791 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 869211002792 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 869211002793 metal binding triad; other site 869211002794 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 869211002795 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 869211002796 AAA domain; Region: AAA_26; pfam13500 869211002797 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 869211002798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211002799 S-adenosylmethionine binding site [chemical binding]; other site 869211002800 Protein of unknown function (DUF452); Region: DUF452; cl01062 869211002801 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 869211002802 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 869211002803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869211002804 catalytic residue [active] 869211002805 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869211002806 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 869211002807 inhibitor-cofactor binding pocket; inhibition site 869211002808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211002809 catalytic residue [active] 869211002810 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211002811 MULE transposase domain; Region: MULE; pfam10551 869211002812 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 869211002813 Nitrogen regulatory protein P-II; Region: P-II; smart00938 869211002814 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 869211002815 Nif-specific regulatory protein; Region: nifA; TIGR01817 869211002816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869211002817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211002818 Walker A motif; other site 869211002819 ATP binding site [chemical binding]; other site 869211002820 Walker B motif; other site 869211002821 arginine finger; other site 869211002822 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869211002823 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 869211002824 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869211002825 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869211002826 dimer interface [polypeptide binding]; other site 869211002827 ssDNA binding site [nucleotide binding]; other site 869211002828 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869211002829 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869211002830 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869211002831 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869211002832 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869211002833 replicative DNA helicase; Region: DnaB; TIGR00665 869211002834 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869211002835 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869211002836 Walker A motif; other site 869211002837 ATP binding site [chemical binding]; other site 869211002838 Walker B motif; other site 869211002839 DNA binding loops [nucleotide binding] 869211002840 FOG: WD40 repeat [General function prediction only]; Region: COG2319 869211002841 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 869211002842 RIP metalloprotease RseP; Region: TIGR00054 869211002843 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869211002844 active site 869211002845 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 869211002846 protein binding site [polypeptide binding]; other site 869211002847 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 869211002848 protein binding site [polypeptide binding]; other site 869211002849 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869211002850 putative substrate binding region [chemical binding]; other site 869211002851 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 869211002852 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 869211002853 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 869211002854 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 869211002855 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869211002856 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869211002857 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 869211002858 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 869211002859 catalytic residue [active] 869211002860 putative FPP diphosphate binding site; other site 869211002861 putative FPP binding hydrophobic cleft; other site 869211002862 dimer interface [polypeptide binding]; other site 869211002863 putative IPP diphosphate binding site; other site 869211002864 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869211002865 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869211002866 hinge region; other site 869211002867 elongation factor Ts; Provisional; Region: tsf; PRK09377 869211002868 UBA/TS-N domain; Region: UBA; pfam00627 869211002869 Elongation factor TS; Region: EF_TS; pfam00889 869211002870 Elongation factor TS; Region: EF_TS; pfam00889 869211002871 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869211002872 rRNA interaction site [nucleotide binding]; other site 869211002873 S8 interaction site; other site 869211002874 putative laminin-1 binding site; other site 869211002875 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 869211002876 active site 869211002877 dimer interface [polypeptide binding]; other site 869211002878 phosphodiesterase; Provisional; Region: PRK12704 869211002879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211002880 Zn2+ binding site [ion binding]; other site 869211002881 Mg2+ binding site [ion binding]; other site 869211002882 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869211002883 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 869211002884 putative active site [active] 869211002885 metal binding site [ion binding]; metal-binding site 869211002886 homodimer binding site [polypeptide binding]; other site 869211002887 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 869211002888 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 869211002889 Sporulation and spore germination; Region: Germane; pfam10646 869211002890 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869211002891 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869211002892 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869211002893 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869211002894 GTP-binding protein Der; Reviewed; Region: PRK00093 869211002895 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869211002896 G1 box; other site 869211002897 GTP/Mg2+ binding site [chemical binding]; other site 869211002898 G2 box; other site 869211002899 Switch I region; other site 869211002900 G3 box; other site 869211002901 Switch II region; other site 869211002902 G4 box; other site 869211002903 G5 box; other site 869211002904 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869211002905 G1 box; other site 869211002906 GTP/Mg2+ binding site [chemical binding]; other site 869211002907 Switch I region; other site 869211002908 G2 box; other site 869211002909 G3 box; other site 869211002910 Switch II region; other site 869211002911 G4 box; other site 869211002912 G5 box; other site 869211002913 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 869211002914 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869211002915 DNA binding residues [nucleotide binding] 869211002916 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 869211002917 FliG C-terminal domain; Region: FliG_C; pfam01706 869211002918 TM2 domain; Region: TM2; pfam05154 869211002919 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 869211002920 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869211002921 ligand binding site [chemical binding]; other site 869211002922 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 869211002923 Rrf2 family protein; Region: rrf2_super; TIGR00738 869211002924 Transcriptional regulator; Region: Rrf2; pfam02082 869211002925 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869211002926 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869211002927 dimer interface [polypeptide binding]; other site 869211002928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211002929 catalytic residue [active] 869211002930 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 869211002931 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869211002932 homodimer interface [polypeptide binding]; other site 869211002933 substrate-cofactor binding pocket; other site 869211002934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211002935 catalytic residue [active] 869211002936 hypothetical protein; Reviewed; Region: PRK00024 869211002937 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869211002938 MPN+ (JAMM) motif; other site 869211002939 Zinc-binding site [ion binding]; other site 869211002940 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 869211002941 dimer interface [polypeptide binding]; other site 869211002942 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 869211002943 active site 869211002944 heme binding site [chemical binding]; other site 869211002945 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 869211002946 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 869211002947 electron transport complex RsxE subunit; Provisional; Region: PRK12405 869211002948 FMN-binding domain; Region: FMN_bind; cl01081 869211002949 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 869211002950 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 869211002951 SLBB domain; Region: SLBB; pfam10531 869211002952 ferredoxin; Validated; Region: PRK07118 869211002953 Putative Fe-S cluster; Region: FeS; cl17515 869211002954 4Fe-4S binding domain; Region: Fer4; pfam00037 869211002955 4Fe-4S binding domain; Region: Fer4; pfam00037 869211002956 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 869211002957 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 869211002958 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 869211002959 active site 869211002960 homodimer interface [polypeptide binding]; other site 869211002961 catalytic site [active] 869211002962 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211002963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211002964 CAAX protease self-immunity; Region: Abi; pfam02517 869211002965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869211002966 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 869211002967 catalytic site [active] 869211002968 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869211002969 active site 869211002970 dimer interface [polypeptide binding]; other site 869211002971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869211002972 active site 869211002973 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869211002974 Predicted transcriptional regulator [Transcription]; Region: COG1959 869211002975 Transcriptional regulator; Region: Rrf2; cl17282 869211002976 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869211002977 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869211002978 dimer interface [polypeptide binding]; other site 869211002979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211002980 catalytic residue [active] 869211002981 elongation factor P; Validated; Region: PRK00529 869211002982 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869211002983 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869211002984 RNA binding site [nucleotide binding]; other site 869211002985 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869211002986 RNA binding site [nucleotide binding]; other site 869211002987 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869211002988 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 869211002989 motif 1; other site 869211002990 dimer interface [polypeptide binding]; other site 869211002991 active site 869211002992 motif 2; other site 869211002993 motif 3; other site 869211002994 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869211002995 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 869211002996 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869211002997 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 869211002998 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869211002999 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869211003000 Survival protein SurE; Region: SurE; cl00448 869211003001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003002 binding surface 869211003003 TPR motif; other site 869211003004 TPR repeat; Region: TPR_11; pfam13414 869211003005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003006 binding surface 869211003007 TPR motif; other site 869211003008 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003009 TPR repeat; Region: TPR_11; pfam13414 869211003010 Uncharacterized conserved protein [Function unknown]; Region: COG3391 869211003011 NHL repeat; Region: NHL; pfam01436 869211003012 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 869211003013 von Willebrand factor type A domain; Region: VWA_2; pfam13519 869211003014 Flagellin N-methylase; Region: FliB; cl00497 869211003015 Uncharacterized conserved protein [Function unknown]; Region: COG2127 869211003016 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 869211003017 Clp amino terminal domain; Region: Clp_N; pfam02861 869211003018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003019 Walker A motif; other site 869211003020 ATP binding site [chemical binding]; other site 869211003021 Walker B motif; other site 869211003022 arginine finger; other site 869211003023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003024 Walker A motif; other site 869211003025 ATP binding site [chemical binding]; other site 869211003026 Walker B motif; other site 869211003027 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869211003028 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 869211003029 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211003030 MULE transposase domain; Region: MULE; pfam10551 869211003031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211003032 AAA domain; Region: AAA_23; pfam13476 869211003033 AAA domain; Region: AAA_21; pfam13304 869211003034 Walker A/P-loop; other site 869211003035 ATP binding site [chemical binding]; other site 869211003036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869211003037 ABC transporter signature motif; other site 869211003038 Walker B; other site 869211003039 D-loop; other site 869211003040 H-loop/switch region; other site 869211003041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003042 binding surface 869211003043 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003044 TPR motif; other site 869211003045 TPR repeat; Region: TPR_11; pfam13414 869211003046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003047 TPR motif; other site 869211003048 binding surface 869211003049 adenylate kinase; Reviewed; Region: adk; PRK00279 869211003050 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869211003051 AMP-binding site [chemical binding]; other site 869211003052 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869211003053 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 869211003054 putative CheA interaction surface; other site 869211003055 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869211003056 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869211003057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869211003058 catalytic residue [active] 869211003059 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 869211003060 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869211003061 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869211003062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211003063 Walker A/P-loop; other site 869211003064 ATP binding site [chemical binding]; other site 869211003065 Q-loop/lid; other site 869211003066 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869211003067 ABC transporter signature motif; other site 869211003068 Walker B; other site 869211003069 D-loop; other site 869211003070 H-loop/switch region; other site 869211003071 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869211003072 active site 869211003073 catalytic motif [active] 869211003074 Zn binding site [ion binding]; other site 869211003075 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869211003076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211003077 S-adenosylmethionine binding site [chemical binding]; other site 869211003078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 869211003079 Uncharacterized conserved protein [Function unknown]; Region: COG1543 869211003080 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 869211003081 active site 869211003082 substrate binding site [chemical binding]; other site 869211003083 catalytic site [active] 869211003084 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 869211003085 cell division protein MraZ; Reviewed; Region: PRK00326 869211003086 MraZ protein; Region: MraZ; pfam02381 869211003087 MraZ protein; Region: MraZ; pfam02381 869211003088 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869211003089 MraW methylase family; Region: Methyltransf_5; cl17771 869211003090 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869211003091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869211003092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869211003093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869211003094 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869211003095 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869211003096 Mg++ binding site [ion binding]; other site 869211003097 putative catalytic motif [active] 869211003098 putative substrate binding site [chemical binding]; other site 869211003099 cell division protein FtsW; Region: ftsW; TIGR02614 869211003100 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 869211003101 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869211003102 cell division protein FtsA; Region: ftsA; TIGR01174 869211003103 Cell division protein FtsA; Region: FtsA; smart00842 869211003104 Cell division protein FtsA; Region: FtsA; pfam14450 869211003105 cell division protein FtsZ; Validated; Region: PRK09330 869211003106 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869211003107 nucleotide binding site [chemical binding]; other site 869211003108 SulA interaction site; other site 869211003109 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869211003110 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 869211003111 active site 869211003112 DNA binding site [nucleotide binding] 869211003113 Int/Topo IB signature motif; other site 869211003114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003115 TPR repeat; Region: TPR_11; pfam13414 869211003116 binding surface 869211003117 TPR motif; other site 869211003118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869211003119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003120 binding surface 869211003121 TPR motif; other site 869211003122 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 869211003123 DNA protecting protein DprA; Region: dprA; TIGR00732 869211003124 DNA topoisomerase I; Validated; Region: PRK05582 869211003125 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869211003126 active site 869211003127 interdomain interaction site; other site 869211003128 putative metal-binding site [ion binding]; other site 869211003129 nucleotide binding site [chemical binding]; other site 869211003130 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869211003131 domain I; other site 869211003132 DNA binding groove [nucleotide binding] 869211003133 phosphate binding site [ion binding]; other site 869211003134 domain II; other site 869211003135 domain III; other site 869211003136 nucleotide binding site [chemical binding]; other site 869211003137 catalytic site [active] 869211003138 domain IV; other site 869211003139 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869211003140 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869211003141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869211003142 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 869211003143 active site 869211003144 DNA binding site [nucleotide binding] 869211003145 Int/Topo IB signature motif; other site 869211003146 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 869211003147 active site 869211003148 HslU subunit interaction site [polypeptide binding]; other site 869211003149 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 869211003150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003151 Walker A motif; other site 869211003152 ATP binding site [chemical binding]; other site 869211003153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003154 Walker B motif; other site 869211003155 arginine finger; other site 869211003156 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869211003157 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624 869211003158 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 869211003159 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869211003160 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869211003161 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 869211003162 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 869211003163 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 869211003164 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 869211003165 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 869211003166 FliG C-terminal domain; Region: FliG_C; pfam01706 869211003167 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 869211003168 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 869211003169 Flagellar assembly protein FliH; Region: FliH; pfam02108 869211003170 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 869211003171 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 869211003172 Walker A motif/ATP binding site; other site 869211003173 Walker B motif; other site 869211003174 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 869211003175 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 869211003176 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 869211003177 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869211003178 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 869211003179 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869211003180 Flagellar protein (FlbD); Region: FlbD; pfam06289 869211003181 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 869211003182 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 869211003183 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 869211003184 flagellar motor protein MotB; Validated; Region: motB; PRK06667 869211003185 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869211003186 ligand binding site [chemical binding]; other site 869211003187 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 869211003188 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 869211003189 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 869211003190 flagellar motor switch protein; Validated; Region: PRK08119 869211003191 flagellar motor switch protein FliN; Region: fliN; TIGR02480 869211003192 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 869211003193 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 869211003194 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 869211003195 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 869211003196 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 869211003197 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 869211003198 FHIPEP family; Region: FHIPEP; pfam00771 869211003199 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 869211003200 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 869211003201 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869211003202 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 869211003203 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 869211003204 P-loop; other site 869211003205 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 869211003206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211003207 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869211003208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211003209 DNA binding residues [nucleotide binding] 869211003210 Protein of unknown function (DUF342); Region: DUF342; pfam03961 869211003211 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 869211003212 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 869211003213 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 869211003214 AAA domain; Region: AAA_26; pfam13500 869211003215 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869211003216 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 869211003217 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 869211003218 active site 869211003219 catalytic residues [active] 869211003220 metal binding site [ion binding]; metal-binding site 869211003221 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 869211003222 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211003223 MULE transposase domain; Region: MULE; pfam10551 869211003224 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 869211003225 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 869211003226 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 869211003227 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 869211003228 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 869211003229 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 869211003230 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 869211003231 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 869211003232 BNR repeat-like domain; Region: BNR_2; pfam13088 869211003233 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869211003234 active site 869211003235 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 869211003236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211003237 dimerization interface [polypeptide binding]; other site 869211003238 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 869211003239 Double zinc ribbon; Region: DZR; pfam12773 869211003240 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 869211003241 Uncharacterized conserved protein [Function unknown]; Region: COG1430 869211003242 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 869211003243 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 869211003244 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869211003245 generic binding surface II; other site 869211003246 generic binding surface I; other site 869211003247 Radical SAM superfamily; Region: Radical_SAM; pfam04055 869211003248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211003249 FeS/SAM binding site; other site 869211003250 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 869211003251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211003252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211003253 active site 869211003254 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 869211003255 NAD binding site [chemical binding]; other site 869211003256 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 869211003257 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 869211003258 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869211003259 active site 869211003260 metal binding site [ion binding]; metal-binding site 869211003261 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 869211003262 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 869211003263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869211003264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211003265 homodimer interface [polypeptide binding]; other site 869211003266 catalytic residue [active] 869211003267 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 869211003268 Uncharacterized conserved protein [Function unknown]; Region: COG2454 869211003269 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869211003270 PhoH-like protein; Region: PhoH; pfam02562 869211003271 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 869211003272 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 869211003273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211003274 Zn2+ binding site [ion binding]; other site 869211003275 Mg2+ binding site [ion binding]; other site 869211003276 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 869211003277 FOG: CBS domain [General function prediction only]; Region: COG0517 869211003278 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869211003279 Transporter associated domain; Region: CorC_HlyC; smart01091 869211003280 TPR repeat; Region: TPR_11; pfam13414 869211003281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003282 binding surface 869211003283 TPR motif; other site 869211003284 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003286 TPR motif; other site 869211003287 binding surface 869211003288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003289 binding surface 869211003290 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003291 TPR motif; other site 869211003292 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 869211003293 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869211003294 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869211003295 Phosphoglycerate kinase; Region: PGK; pfam00162 869211003296 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 869211003297 substrate binding site [chemical binding]; other site 869211003298 hinge regions; other site 869211003299 ADP binding site [chemical binding]; other site 869211003300 catalytic site [active] 869211003301 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869211003302 triosephosphate isomerase; Provisional; Region: PRK14565 869211003303 substrate binding site [chemical binding]; other site 869211003304 dimer interface [polypeptide binding]; other site 869211003305 catalytic triad [active] 869211003306 Preprotein translocase SecG subunit; Region: SecG; pfam03840 869211003307 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869211003308 HSP70 interaction site [polypeptide binding]; other site 869211003309 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 869211003310 SurA N-terminal domain; Region: SurA_N; pfam09312 869211003311 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 869211003312 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 869211003313 putative RNA binding site [nucleotide binding]; other site 869211003314 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869211003315 active site 869211003316 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 869211003317 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869211003318 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869211003319 protein binding site [polypeptide binding]; other site 869211003320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869211003321 protein binding site [polypeptide binding]; other site 869211003322 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 869211003323 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869211003324 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869211003325 homodimer interface [polypeptide binding]; other site 869211003326 NADP binding site [chemical binding]; other site 869211003327 substrate binding site [chemical binding]; other site 869211003328 putative GTP cyclohydrolase; Provisional; Region: PRK13674 869211003329 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869211003330 purine monophosphate binding site [chemical binding]; other site 869211003331 dimer interface [polypeptide binding]; other site 869211003332 putative catalytic residues [active] 869211003333 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869211003334 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335 869211003335 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869211003336 TRAM domain; Region: TRAM; cl01282 869211003337 Sporulation related domain; Region: SPOR; pfam05036 869211003338 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 869211003339 Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595 869211003340 tetramer interface [polypeptide binding]; other site 869211003341 active site 869211003342 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 869211003343 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869211003344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869211003345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869211003346 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869211003347 active site 869211003348 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869211003349 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869211003350 GDP-binding site [chemical binding]; other site 869211003351 ACT binding site; other site 869211003352 IMP binding site; other site 869211003353 GMP synthase; Reviewed; Region: guaA; PRK00074 869211003354 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869211003355 AMP/PPi binding site [chemical binding]; other site 869211003356 candidate oxyanion hole; other site 869211003357 catalytic triad [active] 869211003358 potential glutamine specificity residues [chemical binding]; other site 869211003359 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869211003360 ATP Binding subdomain [chemical binding]; other site 869211003361 Ligand Binding sites [chemical binding]; other site 869211003362 Dimerization subdomain; other site 869211003363 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 869211003364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211003365 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211003366 DNA binding residues [nucleotide binding] 869211003367 Outer membrane efflux protein; Region: OEP; pfam02321 869211003368 HlyD family secretion protein; Region: HlyD_2; pfam12700 869211003369 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869211003370 HlyD family secretion protein; Region: HlyD_3; pfam13437 869211003371 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211003372 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869211003373 Walker A/P-loop; other site 869211003374 ATP binding site [chemical binding]; other site 869211003375 Q-loop/lid; other site 869211003376 ABC transporter signature motif; other site 869211003377 Walker B; other site 869211003378 D-loop; other site 869211003379 H-loop/switch region; other site 869211003380 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211003381 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869211003382 FtsX-like permease family; Region: FtsX; pfam02687 869211003383 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211003384 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869211003385 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211003386 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211003387 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869211003388 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 869211003389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211003390 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869211003391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211003392 DNA binding residues [nucleotide binding] 869211003393 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 869211003394 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869211003395 putative active site [active] 869211003396 nucleotide binding site [chemical binding]; other site 869211003397 nudix motif; other site 869211003398 putative metal binding site [ion binding]; other site 869211003399 Protein of unknown function (DUF763); Region: DUF763; pfam05559 869211003400 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211003401 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211003402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211003403 dimer interface [polypeptide binding]; other site 869211003404 conserved gate region; other site 869211003405 putative PBP binding loops; other site 869211003406 ABC-ATPase subunit interface; other site 869211003407 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211003408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211003409 dimer interface [polypeptide binding]; other site 869211003410 conserved gate region; other site 869211003411 putative PBP binding loops; other site 869211003412 ABC-ATPase subunit interface; other site 869211003413 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 869211003414 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 869211003415 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 869211003416 trimer interface [polypeptide binding]; other site 869211003417 active site 869211003418 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 869211003419 catalytic site [active] 869211003420 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211003421 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211003422 DNA binding site [nucleotide binding] 869211003423 domain linker motif; other site 869211003424 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869211003425 putative dimerization interface [polypeptide binding]; other site 869211003426 putative ligand binding site [chemical binding]; other site 869211003427 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 869211003428 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 869211003429 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 869211003430 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 869211003431 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869211003432 active site 869211003433 HIGH motif; other site 869211003434 KMSK motif region; other site 869211003435 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869211003436 tRNA binding surface [nucleotide binding]; other site 869211003437 anticodon binding site; other site 869211003438 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 869211003439 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 869211003440 active site 869211003441 dimer interface [polypeptide binding]; other site 869211003442 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 869211003443 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 869211003444 active site 869211003445 FMN binding site [chemical binding]; other site 869211003446 substrate binding site [chemical binding]; other site 869211003447 3Fe-4S cluster binding site [ion binding]; other site 869211003448 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 869211003449 domain interface; other site 869211003450 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 869211003451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869211003452 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 869211003453 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869211003454 Protein of unknown function (DUF464); Region: DUF464; cl01080 869211003455 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869211003456 GTPase CgtA; Reviewed; Region: obgE; PRK12299 869211003457 GTP1/OBG; Region: GTP1_OBG; pfam01018 869211003458 Obg GTPase; Region: Obg; cd01898 869211003459 G1 box; other site 869211003460 GTP/Mg2+ binding site [chemical binding]; other site 869211003461 Switch I region; other site 869211003462 G2 box; other site 869211003463 G3 box; other site 869211003464 Switch II region; other site 869211003465 G4 box; other site 869211003466 G5 box; other site 869211003467 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 869211003468 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869211003469 active site 869211003470 (T/H)XGH motif; other site 869211003471 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211003472 Zn2+ binding site [ion binding]; other site 869211003473 Mg2+ binding site [ion binding]; other site 869211003474 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869211003475 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 869211003476 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 869211003477 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 869211003478 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211003479 MULE transposase domain; Region: MULE; pfam10551 869211003480 Transposase domain (DUF772); Region: DUF772; pfam05598 869211003481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211003482 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 869211003483 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869211003484 dimerization interface [polypeptide binding]; other site 869211003485 active site 869211003486 L-aspartate oxidase; Region: nadB; TIGR00551 869211003487 L-aspartate oxidase; Provisional; Region: PRK06175 869211003488 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 869211003489 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 869211003490 regulatory protein SpoVG; Reviewed; Region: PRK13259 869211003491 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 869211003492 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 869211003493 5S rRNA interface [nucleotide binding]; other site 869211003494 CTC domain interface [polypeptide binding]; other site 869211003495 L16 interface [polypeptide binding]; other site 869211003496 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869211003497 putative active site [active] 869211003498 catalytic residue [active] 869211003499 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869211003500 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869211003501 Ligand Binding Site [chemical binding]; other site 869211003502 TilS substrate C-terminal domain; Region: TilS_C; cl17443 869211003503 FtsH Extracellular; Region: FtsH_ext; pfam06480 869211003504 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 869211003505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003506 Walker A motif; other site 869211003507 ATP binding site [chemical binding]; other site 869211003508 Walker B motif; other site 869211003509 arginine finger; other site 869211003510 Peptidase family M41; Region: Peptidase_M41; pfam01434 869211003511 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869211003512 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869211003513 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 869211003514 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869211003515 RNA/DNA hybrid binding site [nucleotide binding]; other site 869211003516 active site 869211003517 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 869211003518 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869211003519 Walker A/P-loop; other site 869211003520 ATP binding site [chemical binding]; other site 869211003521 Q-loop/lid; other site 869211003522 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869211003523 ABC transporter signature motif; other site 869211003524 Walker B; other site 869211003525 D-loop; other site 869211003526 H-loop/switch region; other site 869211003527 signal recognition particle protein; Provisional; Region: PRK10867 869211003528 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869211003529 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869211003530 P loop; other site 869211003531 GTP binding site [chemical binding]; other site 869211003532 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869211003533 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 869211003534 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 869211003535 hypothetical protein; Provisional; Region: PRK00468 869211003536 G-X-X-G motif; other site 869211003537 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 869211003538 RimM N-terminal domain; Region: RimM; pfam01782 869211003539 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869211003540 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869211003541 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 869211003542 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 869211003543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211003544 Zn2+ binding site [ion binding]; other site 869211003545 Mg2+ binding site [ion binding]; other site 869211003546 hypothetical protein; Reviewed; Region: PRK12497 869211003547 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 869211003548 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869211003549 active site 869211003550 (T/H)XGH motif; other site 869211003551 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 869211003552 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 869211003553 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 869211003554 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 869211003555 acyl carrier protein; Provisional; Region: acpP; PRK00982 869211003556 ribonuclease III; Reviewed; Region: rnc; PRK00102 869211003557 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869211003558 dimerization interface [polypeptide binding]; other site 869211003559 active site 869211003560 metal binding site [ion binding]; metal-binding site 869211003561 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869211003562 dsRNA binding site [nucleotide binding]; other site 869211003563 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869211003564 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 869211003565 active site 869211003566 NTP binding site [chemical binding]; other site 869211003567 metal binding triad [ion binding]; metal-binding site 869211003568 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869211003569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211003570 Zn2+ binding site [ion binding]; other site 869211003571 Mg2+ binding site [ion binding]; other site 869211003572 flagellin; Provisional; Region: PRK12804 869211003573 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869211003574 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 869211003575 Thiamine pyrophosphokinase; Region: TPK; cd07995 869211003576 active site 869211003577 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 869211003578 dimerization interface [polypeptide binding]; other site 869211003579 thiamine binding site [chemical binding]; other site 869211003580 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 869211003581 nucleotide binding site/active site [active] 869211003582 HIT family signature motif; other site 869211003583 catalytic residue [active] 869211003584 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 869211003585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211003586 motif II; other site 869211003587 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869211003588 active site 869211003589 Flagellin N-methylase; Region: FliB; cl00497 869211003590 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869211003591 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211003592 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211003593 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 869211003594 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 869211003595 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211003596 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211003597 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 869211003598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869211003599 ligand binding site [chemical binding]; other site 869211003600 YceG-like family; Region: YceG; pfam02618 869211003601 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869211003602 dimerization interface [polypeptide binding]; other site 869211003603 DNA primase; Validated; Region: dnaG; PRK05667 869211003604 CHC2 zinc finger; Region: zf-CHC2; cl17510 869211003605 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869211003606 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869211003607 active site 869211003608 metal binding site [ion binding]; metal-binding site 869211003609 interdomain interaction site; other site 869211003610 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 869211003611 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869211003612 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869211003613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211003614 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869211003615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211003616 DNA binding residues [nucleotide binding] 869211003617 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 869211003618 Lactococcus lactis bacteriophage major capsid protein; Region: L_lactis_ph-MCP; pfam06673 869211003619 Putative zinc ribbon domain; Region: DUF164; pfam02591 869211003620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869211003621 binding surface 869211003622 TPR motif; other site 869211003623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003624 binding surface 869211003625 TPR repeat; Region: TPR_11; pfam13414 869211003626 TPR motif; other site 869211003627 rod shape-determining protein MreB; Provisional; Region: PRK13927 869211003628 MreB and similar proteins; Region: MreB_like; cd10225 869211003629 nucleotide binding site [chemical binding]; other site 869211003630 Mg binding site [ion binding]; other site 869211003631 putative protofilament interaction site [polypeptide binding]; other site 869211003632 RodZ interaction site [polypeptide binding]; other site 869211003633 rod shape-determining protein MreC; Provisional; Region: PRK13922 869211003634 rod shape-determining protein MreC; Region: MreC; pfam04085 869211003635 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 869211003636 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869211003637 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869211003638 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 869211003639 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 869211003640 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 869211003641 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 869211003642 B12 binding site [chemical binding]; other site 869211003643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211003644 FeS/SAM binding site; other site 869211003645 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 869211003646 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 869211003647 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 869211003648 homodimer interface [polypeptide binding]; other site 869211003649 metal binding site [ion binding]; metal-binding site 869211003650 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 869211003651 homodimer interface [polypeptide binding]; other site 869211003652 active site 869211003653 putative chemical substrate binding site [chemical binding]; other site 869211003654 metal binding site [ion binding]; metal-binding site 869211003655 CHASE2 domain; Region: CHASE2; pfam05226 869211003656 CHASE2 domain; Region: CHASE2; pfam05226 869211003657 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 869211003658 cyclase homology domain; Region: CHD; cd07302 869211003659 nucleotidyl binding site; other site 869211003660 metal binding site [ion binding]; metal-binding site 869211003661 dimer interface [polypeptide binding]; other site 869211003662 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 869211003663 Tetratricopeptide repeat; Region: TPR_6; pfam13174 869211003664 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 869211003665 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869211003666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003667 Walker A motif; other site 869211003668 ATP binding site [chemical binding]; other site 869211003669 Walker B motif; other site 869211003670 arginine finger; other site 869211003671 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 869211003672 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 869211003673 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869211003674 CMP-binding site; other site 869211003675 The sites determining sugar specificity; other site 869211003676 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 869211003677 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 869211003678 RNA binding site [nucleotide binding]; other site 869211003679 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869211003680 RNA binding site [nucleotide binding]; other site 869211003681 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869211003682 RNA binding site [nucleotide binding]; other site 869211003683 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 869211003684 RNA binding site [nucleotide binding]; other site 869211003685 S1 RNA binding domain; Region: S1; pfam00575 869211003686 RNA binding site [nucleotide binding]; other site 869211003687 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 869211003688 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869211003689 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869211003690 RNA binding surface [nucleotide binding]; other site 869211003691 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 869211003692 active site 869211003693 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 869211003694 ScpA/B protein; Region: ScpA_ScpB; cl00598 869211003695 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869211003696 catalytic center binding site [active] 869211003697 ATP binding site [chemical binding]; other site 869211003698 recombinase A; Provisional; Region: recA; PRK09354 869211003699 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869211003700 hexamer interface [polypeptide binding]; other site 869211003701 Walker A motif; other site 869211003702 ATP binding site [chemical binding]; other site 869211003703 Walker B motif; other site 869211003704 Transposase domain (DUF772); Region: DUF772; pfam05598 869211003705 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211003706 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869211003707 putative active site [active] 869211003708 dimerization interface [polypeptide binding]; other site 869211003709 putative tRNAtyr binding site [nucleotide binding]; other site 869211003710 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003712 TPR motif; other site 869211003713 binding surface 869211003714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003715 binding surface 869211003716 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003717 TPR motif; other site 869211003718 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003719 capsid protein IX,hexon associated protein IX; Provisional; Region: IX; PHA03385 869211003720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869211003721 binding surface 869211003722 TPR motif; other site 869211003723 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 869211003724 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869211003725 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869211003726 HEAT repeats; Region: HEAT_2; pfam13646 869211003727 HEAT repeats; Region: HEAT_2; pfam13646 869211003728 MviN-like protein; Region: MVIN; pfam03023 869211003729 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 869211003730 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869211003731 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 869211003732 Predicted permeases [General function prediction only]; Region: COG0795 869211003733 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869211003734 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869211003735 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 869211003736 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 869211003737 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869211003738 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869211003739 RNase E interface [polypeptide binding]; other site 869211003740 trimer interface [polypeptide binding]; other site 869211003741 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869211003742 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869211003743 RNase E interface [polypeptide binding]; other site 869211003744 trimer interface [polypeptide binding]; other site 869211003745 active site 869211003746 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869211003747 putative nucleic acid binding region [nucleotide binding]; other site 869211003748 G-X-X-G motif; other site 869211003749 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869211003750 RNA binding site [nucleotide binding]; other site 869211003751 domain interface; other site 869211003752 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869211003753 16S/18S rRNA binding site [nucleotide binding]; other site 869211003754 S13e-L30e interaction site [polypeptide binding]; other site 869211003755 25S rRNA binding site [nucleotide binding]; other site 869211003756 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 869211003757 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869211003758 active site 869211003759 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 869211003760 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869211003761 RNA binding site [nucleotide binding]; other site 869211003762 active site 869211003763 Ribosome-binding factor A; Region: RBFA; pfam02033 869211003764 translation initiation factor IF-2; Region: IF-2; TIGR00487 869211003765 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869211003766 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869211003767 G1 box; other site 869211003768 putative GEF interaction site [polypeptide binding]; other site 869211003769 GTP/Mg2+ binding site [chemical binding]; other site 869211003770 Switch I region; other site 869211003771 G2 box; other site 869211003772 G3 box; other site 869211003773 Switch II region; other site 869211003774 G4 box; other site 869211003775 G5 box; other site 869211003776 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869211003777 Translation-initiation factor 2; Region: IF-2; pfam11987 869211003778 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869211003779 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 869211003780 NusA N-terminal domain; Region: NusA_N; pfam08529 869211003781 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869211003782 RNA binding site [nucleotide binding]; other site 869211003783 homodimer interface [polypeptide binding]; other site 869211003784 NusA-like KH domain; Region: KH_5; pfam13184 869211003785 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869211003786 G-X-X-G motif; other site 869211003787 Double zinc ribbon; Region: DZR; pfam12773 869211003788 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 869211003789 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 869211003790 Sm and related proteins; Region: Sm_like; cl00259 869211003791 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869211003792 putative oligomer interface [polypeptide binding]; other site 869211003793 putative RNA binding site [nucleotide binding]; other site 869211003794 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211003795 MULE transposase domain; Region: MULE; pfam10551 869211003796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211003797 Histidine kinase; Region: HisKA_2; pfam07568 869211003798 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 869211003799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869211003800 active site 869211003801 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 869211003802 MutS domain I; Region: MutS_I; pfam01624 869211003803 MutS domain II; Region: MutS_II; pfam05188 869211003804 MutS domain III; Region: MutS_III; pfam05192 869211003805 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869211003806 Walker A/P-loop; other site 869211003807 ATP binding site [chemical binding]; other site 869211003808 Q-loop/lid; other site 869211003809 ABC transporter signature motif; other site 869211003810 Walker B; other site 869211003811 D-loop; other site 869211003812 H-loop/switch region; other site 869211003813 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 869211003814 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869211003815 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869211003816 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869211003817 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869211003818 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869211003819 Surface antigen; Region: Bac_surface_Ag; pfam01103 869211003820 Surface antigen; Region: Bac_surface_Ag; pfam01103 869211003821 Family of unknown function (DUF490); Region: DUF490; pfam04357 869211003822 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 869211003823 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869211003824 TMP-binding site; other site 869211003825 ATP-binding site [chemical binding]; other site 869211003826 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 869211003827 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869211003828 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869211003829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211003830 Walker A motif; other site 869211003831 ATP binding site [chemical binding]; other site 869211003832 Walker B motif; other site 869211003833 arginine finger; other site 869211003834 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869211003835 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 869211003836 RuvA N terminal domain; Region: RuvA_N; pfam01330 869211003837 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 869211003838 active site 869211003839 putative DNA-binding cleft [nucleotide binding]; other site 869211003840 dimer interface [polypeptide binding]; other site 869211003841 hypothetical protein; Validated; Region: PRK00110 869211003842 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 869211003843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211003844 FeS/SAM binding site; other site 869211003845 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869211003846 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869211003847 Catalytic site [active] 869211003848 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869211003849 PEGA domain; Region: PEGA; pfam08308 869211003850 Uncharacterized conserved protein [Function unknown]; Region: COG1262 869211003851 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 869211003852 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869211003853 SmpB-tmRNA interface; other site 869211003854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003855 binding surface 869211003856 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211003857 TPR motif; other site 869211003858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211003859 binding surface 869211003860 TPR motif; other site 869211003861 TPR repeat; Region: TPR_11; pfam13414 869211003862 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 869211003863 Predicted permease; Region: DUF318; cl17795 869211003864 Predicted permease; Region: DUF318; cl17795 869211003865 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 869211003866 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 869211003867 Ferredoxin [Energy production and conversion]; Region: COG1146 869211003868 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869211003869 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 869211003870 gating phenylalanine in ion channel; other site 869211003871 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 869211003872 Sodium Bile acid symporter family; Region: SBF; cl17470 869211003873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211003874 dimerization interface [polypeptide binding]; other site 869211003875 putative DNA binding site [nucleotide binding]; other site 869211003876 putative Zn2+ binding site [ion binding]; other site 869211003877 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 869211003878 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869211003879 ligand binding site [chemical binding]; other site 869211003880 Protein of unknown function (DUF429); Region: DUF429; pfam04250 869211003881 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 869211003882 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 869211003883 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 869211003884 metal binding triad [ion binding]; metal-binding site 869211003885 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211003886 active site 869211003887 NTP binding site [chemical binding]; other site 869211003888 metal binding triad [ion binding]; metal-binding site 869211003889 antibiotic binding site [chemical binding]; other site 869211003890 Protein of unknown function DUF86; Region: DUF86; cl01031 869211003891 SurA N-terminal domain; Region: SurA_N_3; cl07813 869211003892 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 869211003893 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 869211003894 GTP-binding protein LepA; Provisional; Region: PRK05433 869211003895 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869211003896 G1 box; other site 869211003897 putative GEF interaction site [polypeptide binding]; other site 869211003898 GTP/Mg2+ binding site [chemical binding]; other site 869211003899 Switch I region; other site 869211003900 G2 box; other site 869211003901 G3 box; other site 869211003902 Switch II region; other site 869211003903 G4 box; other site 869211003904 G5 box; other site 869211003905 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869211003906 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869211003907 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869211003908 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211003909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211003910 active site 869211003911 phosphorylation site [posttranslational modification] 869211003912 intermolecular recognition site; other site 869211003913 dimerization interface [polypeptide binding]; other site 869211003914 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 869211003915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211003916 putative active site [active] 869211003917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211003918 dimer interface [polypeptide binding]; other site 869211003919 phosphorylation site [posttranslational modification] 869211003920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211003921 ATP binding site [chemical binding]; other site 869211003922 Mg2+ binding site [ion binding]; other site 869211003923 G-X-G motif; other site 869211003924 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211003925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211003926 active site 869211003927 phosphorylation site [posttranslational modification] 869211003928 intermolecular recognition site; other site 869211003929 dimerization interface [polypeptide binding]; other site 869211003930 Response regulator receiver domain; Region: Response_reg; pfam00072 869211003931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211003932 active site 869211003933 phosphorylation site [posttranslational modification] 869211003934 intermolecular recognition site; other site 869211003935 dimerization interface [polypeptide binding]; other site 869211003936 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 869211003937 elongation factor G; Reviewed; Region: PRK12739 869211003938 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869211003939 G1 box; other site 869211003940 putative GEF interaction site [polypeptide binding]; other site 869211003941 GTP/Mg2+ binding site [chemical binding]; other site 869211003942 Switch I region; other site 869211003943 G2 box; other site 869211003944 G3 box; other site 869211003945 Switch II region; other site 869211003946 G4 box; other site 869211003947 G5 box; other site 869211003948 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869211003949 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 869211003950 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869211003951 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 869211003952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211003953 dimerization interface [polypeptide binding]; other site 869211003954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211003955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211003956 dimer interface [polypeptide binding]; other site 869211003957 putative CheW interface [polypeptide binding]; other site 869211003958 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 869211003959 elongation factor G; Reviewed; Region: PRK12740 869211003960 G1 box; other site 869211003961 putative GEF interaction site [polypeptide binding]; other site 869211003962 GTP/Mg2+ binding site [chemical binding]; other site 869211003963 Switch I region; other site 869211003964 G2 box; other site 869211003965 G3 box; other site 869211003966 Switch II region; other site 869211003967 G4 box; other site 869211003968 G5 box; other site 869211003969 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869211003970 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869211003971 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869211003972 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 869211003973 dimer interface [polypeptide binding]; other site 869211003974 Citrate synthase; Region: Citrate_synt; pfam00285 869211003975 active site 869211003976 citrylCoA binding site [chemical binding]; other site 869211003977 oxalacetate/citrate binding site [chemical binding]; other site 869211003978 coenzyme A binding site [chemical binding]; other site 869211003979 catalytic triad [active] 869211003980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211003981 S-adenosylmethionine binding site [chemical binding]; other site 869211003982 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 869211003983 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 869211003984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211003985 ATP binding site [chemical binding]; other site 869211003986 putative Mg++ binding site [ion binding]; other site 869211003987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869211003988 nucleotide binding region [chemical binding]; other site 869211003989 ATP-binding site [chemical binding]; other site 869211003990 TRCF domain; Region: TRCF; pfam03461 869211003991 PilZ domain; Region: PilZ; pfam07238 869211003992 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 869211003993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211003994 FeS/SAM binding site; other site 869211003995 4Fe-4S binding domain; Region: Fer4; cl02805 869211003996 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 869211003997 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211003998 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211003999 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211004000 MULE transposase domain; Region: MULE; pfam10551 869211004001 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869211004002 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869211004003 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869211004004 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 869211004005 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869211004006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211004007 putative Mg++ binding site [ion binding]; other site 869211004008 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 869211004009 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 869211004010 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 869211004011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211004012 S-adenosylmethionine binding site [chemical binding]; other site 869211004013 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 869211004014 oligomeric interface; other site 869211004015 putative active site [active] 869211004016 homodimer interface [polypeptide binding]; other site 869211004017 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869211004018 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869211004019 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 869211004020 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 869211004021 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 869211004022 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 869211004023 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 869211004024 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 869211004025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869211004028 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869211004029 active site 869211004030 catalytic tetrad [active] 869211004031 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 869211004032 short chain dehydrogenase; Provisional; Region: PRK08339 869211004033 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 869211004034 putative NAD(P) binding site [chemical binding]; other site 869211004035 putative active site [active] 869211004036 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 869211004037 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869211004038 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 869211004039 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869211004040 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 869211004041 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 869211004042 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 869211004043 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 869211004044 Walker A/P-loop; other site 869211004045 ATP binding site [chemical binding]; other site 869211004046 Q-loop/lid; other site 869211004047 ABC transporter signature motif; other site 869211004048 Walker B; other site 869211004049 D-loop; other site 869211004050 H-loop/switch region; other site 869211004051 TOBE domain; Region: TOBE_2; pfam08402 869211004052 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 869211004053 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 869211004054 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 869211004055 HEAT repeats; Region: HEAT_2; pfam13646 869211004056 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869211004057 active site 869211004058 catalytic site [active] 869211004059 substrate binding site [chemical binding]; other site 869211004060 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 869211004061 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869211004062 active site 869211004063 substrate binding site [chemical binding]; other site 869211004064 metal binding site [ion binding]; metal-binding site 869211004065 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869211004066 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869211004067 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 869211004068 active site 869211004069 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 869211004070 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869211004071 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869211004072 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869211004073 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869211004074 Protein of unknown function DUF72; Region: DUF72; pfam01904 869211004075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004076 binding surface 869211004077 TPR motif; other site 869211004078 GcpE protein; Region: GcpE; pfam04551 869211004079 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 869211004080 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 869211004081 V-type ATP synthase subunit K; Validated; Region: PRK06649 869211004082 V-type ATP synthase subunit I; Validated; Region: PRK05771 869211004083 V-type ATP synthase subunit D; Provisional; Region: PRK02195 869211004084 V-type ATP synthase subunit B; Provisional; Region: PRK02118 869211004085 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869211004086 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 869211004087 Walker A motif homologous position; other site 869211004088 Walker B motif; other site 869211004089 V-type ATP synthase subunit A; Provisional; Region: PRK04192 869211004090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869211004091 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 869211004092 Walker A motif/ATP binding site; other site 869211004093 Walker B motif; other site 869211004094 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869211004095 V-type ATP synthase subunit E; Provisional; Region: PRK01558 869211004096 V-type ATP synthase subunit E; Provisional; Region: PRK01005 869211004097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211004098 dimerization interface [polypeptide binding]; other site 869211004099 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 869211004100 cyclase homology domain; Region: CHD; cd07302 869211004101 nucleotidyl binding site; other site 869211004102 metal binding site [ion binding]; metal-binding site 869211004103 dimer interface [polypeptide binding]; other site 869211004104 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 869211004105 biotin synthase; Region: bioB; TIGR00433 869211004106 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 869211004107 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869211004108 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869211004109 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 869211004110 cytidylate kinase; Provisional; Region: PRK04182 869211004111 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869211004112 CMP-binding site; other site 869211004113 The sites determining sugar specificity; other site 869211004114 hypothetical protein; Provisional; Region: PRK11820 869211004115 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 869211004116 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 869211004117 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869211004118 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869211004119 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869211004120 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869211004121 Predicted ATPase [General function prediction only]; Region: COG4637 869211004122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211004123 Walker A/P-loop; other site 869211004124 ATP binding site [chemical binding]; other site 869211004125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211004126 putative substrate translocation pore; other site 869211004127 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 869211004128 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 869211004129 dimer interface [polypeptide binding]; other site 869211004130 active site 869211004131 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 869211004132 YibE/F-like protein; Region: YibE_F; pfam07907 869211004133 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 869211004134 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 869211004135 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 869211004136 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 869211004137 putative active site [active] 869211004138 putative metal binding site [ion binding]; other site 869211004139 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 869211004140 4Fe-4S binding domain; Region: Fer4; pfam00037 869211004141 4Fe-4S binding domain; Region: Fer4; cl02805 869211004142 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 869211004143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 869211004144 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 869211004145 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869211004146 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 869211004147 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 869211004148 Putative Fe-S cluster; Region: FeS; cl17515 869211004149 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 869211004150 dimer interface [polypeptide binding]; other site 869211004151 [2Fe-2S] cluster binding site [ion binding]; other site 869211004152 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869211004153 Clp amino terminal domain; Region: Clp_N; pfam02861 869211004154 Clp amino terminal domain; Region: Clp_N; pfam02861 869211004155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211004156 Walker A motif; other site 869211004157 ATP binding site [chemical binding]; other site 869211004158 Walker B motif; other site 869211004159 arginine finger; other site 869211004160 UvrB/uvrC motif; Region: UVR; pfam02151 869211004161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211004162 Walker A motif; other site 869211004163 ATP binding site [chemical binding]; other site 869211004164 Walker B motif; other site 869211004165 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869211004166 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 869211004167 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 869211004168 ADP binding site [chemical binding]; other site 869211004169 phosphagen binding site; other site 869211004170 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 869211004171 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211004172 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211004173 FtsX-like permease family; Region: FtsX; pfam02687 869211004174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211004175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869211004176 Walker A/P-loop; other site 869211004177 ATP binding site [chemical binding]; other site 869211004178 Q-loop/lid; other site 869211004179 ABC transporter signature motif; other site 869211004180 Walker B; other site 869211004181 D-loop; other site 869211004182 H-loop/switch region; other site 869211004183 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211004184 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 869211004185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869211004186 PEGA domain; Region: PEGA; pfam08308 869211004187 peptide chain release factor 2; Validated; Region: prfB; PRK00578 869211004188 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869211004189 RF-1 domain; Region: RF-1; pfam00472 869211004190 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 869211004191 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 869211004192 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 869211004193 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 869211004194 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 869211004195 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 869211004196 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869211004197 dimerization interface [polypeptide binding]; other site 869211004198 ATP binding site [chemical binding]; other site 869211004199 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 869211004200 dimerization interface [polypeptide binding]; other site 869211004201 ATP binding site [chemical binding]; other site 869211004202 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869211004203 putative active site [active] 869211004204 catalytic triad [active] 869211004205 AIR carboxylase; Region: AIRC; pfam00731 869211004206 amidophosphoribosyltransferase; Provisional; Region: PRK05793 869211004207 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869211004208 active site 869211004209 tetramer interface [polypeptide binding]; other site 869211004210 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869211004211 active site 869211004212 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869211004213 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869211004214 dimerization interface [polypeptide binding]; other site 869211004215 putative ATP binding site [chemical binding]; other site 869211004216 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 869211004217 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869211004218 active site 869211004219 substrate binding site [chemical binding]; other site 869211004220 cosubstrate binding site; other site 869211004221 catalytic site [active] 869211004222 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 869211004223 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869211004224 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869211004225 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869211004226 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 869211004227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869211004228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869211004229 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 869211004230 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 869211004231 FAD binding pocket [chemical binding]; other site 869211004232 FAD binding motif [chemical binding]; other site 869211004233 phosphate binding motif [ion binding]; other site 869211004234 beta-alpha-beta structure motif; other site 869211004235 NAD binding pocket [chemical binding]; other site 869211004236 Iron coordination center [ion binding]; other site 869211004237 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211004238 MULE transposase domain; Region: MULE; pfam10551 869211004239 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 869211004240 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869211004241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211004242 FeS/SAM binding site; other site 869211004243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004244 TPR motif; other site 869211004245 TPR repeat; Region: TPR_11; pfam13414 869211004246 binding surface 869211004247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004248 binding surface 869211004249 TPR motif; other site 869211004250 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 869211004251 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 869211004252 arogenate dehydrogenase; Region: PLN02256 869211004253 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869211004254 dihydrodipicolinate reductase; Provisional; Region: PRK00048 869211004255 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869211004256 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869211004257 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869211004258 dihydrodipicolinate synthase; Region: dapA; TIGR00674 869211004259 dimer interface [polypeptide binding]; other site 869211004260 active site 869211004261 catalytic residue [active] 869211004262 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869211004263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211004264 S-adenosylmethionine binding site [chemical binding]; other site 869211004265 Competence protein; Region: Competence; cl00471 869211004266 PilZ domain; Region: PilZ; pfam07238 869211004267 CAAX protease self-immunity; Region: Abi; cl00558 869211004268 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869211004269 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869211004270 catalytic residues [active] 869211004271 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869211004272 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869211004273 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 869211004274 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 869211004275 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869211004276 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869211004277 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869211004278 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869211004279 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869211004280 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869211004281 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869211004282 carboxyltransferase (CT) interaction site; other site 869211004283 biotinylation site [posttranslational modification]; other site 869211004284 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869211004285 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 869211004286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869211004287 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 869211004288 acyl-activating enzyme (AAE) consensus motif; other site 869211004289 putative AMP binding site [chemical binding]; other site 869211004290 putative active site [active] 869211004291 putative CoA binding site [chemical binding]; other site 869211004292 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 869211004293 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 869211004294 active site 869211004295 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869211004296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211004298 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211004299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211004300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004301 dimer interface [polypeptide binding]; other site 869211004302 conserved gate region; other site 869211004303 ABC-ATPase subunit interface; other site 869211004304 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004306 dimer interface [polypeptide binding]; other site 869211004307 conserved gate region; other site 869211004308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869211004309 ABC-ATPase subunit interface; other site 869211004310 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 869211004311 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 869211004312 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211004313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004314 dimer interface [polypeptide binding]; other site 869211004315 conserved gate region; other site 869211004316 putative PBP binding loops; other site 869211004317 ABC-ATPase subunit interface; other site 869211004318 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869211004319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004320 dimer interface [polypeptide binding]; other site 869211004321 conserved gate region; other site 869211004322 putative PBP binding loops; other site 869211004323 ABC-ATPase subunit interface; other site 869211004324 Response regulator receiver domain; Region: Response_reg; pfam00072 869211004325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211004326 active site 869211004327 phosphorylation site [posttranslational modification] 869211004328 intermolecular recognition site; other site 869211004329 dimerization interface [polypeptide binding]; other site 869211004330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004331 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869211004332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004333 HAMP domain; Region: HAMP; pfam00672 869211004334 Histidine kinase; Region: His_kinase; pfam06580 869211004335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211004336 ATP binding site [chemical binding]; other site 869211004337 G-X-G motif; other site 869211004338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211004339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211004340 dimer interface [polypeptide binding]; other site 869211004341 putative CheW interface [polypeptide binding]; other site 869211004342 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 869211004343 L-rhamnose isomerase; Provisional; Region: PRK01076 869211004344 Uncharacterized conserved protein [Function unknown]; Region: COG3347 869211004345 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 869211004346 Domain of unknown function (DUF718); Region: DUF718; pfam05336 869211004347 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211004348 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869211004349 TM-ABC transporter signature motif; other site 869211004350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211004351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869211004352 TM-ABC transporter signature motif; other site 869211004353 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869211004354 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869211004355 Walker A/P-loop; other site 869211004356 ATP binding site [chemical binding]; other site 869211004357 Q-loop/lid; other site 869211004358 ABC transporter signature motif; other site 869211004359 Walker B; other site 869211004360 D-loop; other site 869211004361 H-loop/switch region; other site 869211004362 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869211004363 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 869211004364 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 869211004365 ligand binding site [chemical binding]; other site 869211004366 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 869211004367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211004368 active site 869211004369 phosphorylation site [posttranslational modification] 869211004370 intermolecular recognition site; other site 869211004371 dimerization interface [polypeptide binding]; other site 869211004372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211004374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211004375 dimerization interface [polypeptide binding]; other site 869211004376 Histidine kinase; Region: His_kinase; pfam06580 869211004377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211004378 ATP binding site [chemical binding]; other site 869211004379 Mg2+ binding site [ion binding]; other site 869211004380 G-X-G motif; other site 869211004381 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 869211004382 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869211004383 putative NAD(P) binding site [chemical binding]; other site 869211004384 catalytic Zn binding site [ion binding]; other site 869211004385 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 869211004386 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211004387 nucleotide binding site [chemical binding]; other site 869211004388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211004389 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 869211004390 NAD(P) binding site [chemical binding]; other site 869211004391 active site 869211004392 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 869211004393 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869211004394 active site 869211004395 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 869211004396 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869211004397 tetramer interface [polypeptide binding]; other site 869211004398 TPP-binding site [chemical binding]; other site 869211004399 heterodimer interface [polypeptide binding]; other site 869211004400 phosphorylation loop region [posttranslational modification] 869211004401 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869211004402 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 869211004403 PYR/PP interface [polypeptide binding]; other site 869211004404 dimer interface [polypeptide binding]; other site 869211004405 TPP binding site [chemical binding]; other site 869211004406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869211004407 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 869211004408 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869211004409 E3 interaction surface; other site 869211004410 lipoyl attachment site [posttranslational modification]; other site 869211004411 e3 binding domain; Region: E3_binding; pfam02817 869211004412 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869211004413 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869211004414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211004415 putative DNA binding site [nucleotide binding]; other site 869211004416 putative Zn2+ binding site [ion binding]; other site 869211004417 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869211004418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211004419 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211004420 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869211004421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004422 dimer interface [polypeptide binding]; other site 869211004423 ABC-ATPase subunit interface; other site 869211004424 putative PBP binding loops; other site 869211004425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211004426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004427 dimer interface [polypeptide binding]; other site 869211004428 conserved gate region; other site 869211004429 putative PBP binding loops; other site 869211004430 ABC-ATPase subunit interface; other site 869211004431 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 869211004432 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 869211004433 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 869211004434 NAD(P) binding site [chemical binding]; other site 869211004435 LDH/MDH dimer interface [polypeptide binding]; other site 869211004436 substrate binding site [chemical binding]; other site 869211004437 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 869211004438 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869211004439 nucleotide binding pocket [chemical binding]; other site 869211004440 K-X-D-G motif; other site 869211004441 catalytic site [active] 869211004442 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869211004443 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869211004444 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869211004445 Dimer interface [polypeptide binding]; other site 869211004446 BRCT sequence motif; other site 869211004447 Sporulation related domain; Region: SPOR; pfam05036 869211004448 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869211004449 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 869211004450 NAD(P) binding site [chemical binding]; other site 869211004451 homodimer interface [polypeptide binding]; other site 869211004452 substrate binding site [chemical binding]; other site 869211004453 active site 869211004454 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869211004455 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869211004456 inhibitor-cofactor binding pocket; inhibition site 869211004457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211004458 catalytic residue [active] 869211004459 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 869211004460 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 869211004461 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 869211004462 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 869211004463 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 869211004464 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 869211004465 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 869211004466 active site 869211004467 PHP Thumb interface [polypeptide binding]; other site 869211004468 metal binding site [ion binding]; metal-binding site 869211004469 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869211004470 generic binding surface I; other site 869211004471 generic binding surface II; other site 869211004472 YGGT family; Region: YGGT; pfam02325 869211004473 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869211004474 Y-family of DNA polymerases; Region: PolY; cl12025 869211004475 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869211004476 generic binding surface II; other site 869211004477 ssDNA binding site; other site 869211004478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211004479 ATP binding site [chemical binding]; other site 869211004480 putative Mg++ binding site [ion binding]; other site 869211004481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869211004482 nucleotide binding region [chemical binding]; other site 869211004483 ATP-binding site [chemical binding]; other site 869211004484 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 869211004485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211004486 S-adenosylmethionine binding site [chemical binding]; other site 869211004487 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 869211004488 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869211004489 motif 1; other site 869211004490 dimer interface [polypeptide binding]; other site 869211004491 active site 869211004492 motif 2; other site 869211004493 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 869211004494 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 869211004495 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 869211004496 putative active site pocket [active] 869211004497 4-fold oligomerization interface [polypeptide binding]; other site 869211004498 metal binding residues [ion binding]; metal-binding site 869211004499 3-fold/trimer interface [polypeptide binding]; other site 869211004500 TPR repeat; Region: TPR_11; pfam13414 869211004501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004502 binding surface 869211004503 TPR repeat; Region: TPR_11; pfam13414 869211004504 TPR motif; other site 869211004505 TPR repeat; Region: TPR_11; pfam13414 869211004506 TPR repeat; Region: TPR_11; pfam13414 869211004507 TPR repeat; Region: TPR_11; pfam13414 869211004508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004509 binding surface 869211004510 TPR motif; other site 869211004511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004512 TPR motif; other site 869211004513 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211004514 binding surface 869211004515 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 869211004516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211004517 FeS/SAM binding site; other site 869211004518 alanyl-tRNA synthetase; Provisional; Region: PRK01584 869211004519 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869211004520 motif 1; other site 869211004521 active site 869211004522 motif 2; other site 869211004523 motif 3; other site 869211004524 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869211004525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869211004526 active site 869211004527 phosphorylation site [posttranslational modification] 869211004528 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 869211004529 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 869211004530 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 869211004531 transmembrane helices; other site 869211004532 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 869211004533 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 869211004534 Part of AAA domain; Region: AAA_19; pfam13245 869211004535 AAA domain; Region: AAA_14; pfam13173 869211004536 Family description; Region: UvrD_C_2; pfam13538 869211004537 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 869211004538 nudix motif; other site 869211004539 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869211004540 active site 869211004541 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 869211004542 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 869211004543 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869211004544 intersubunit interface [polypeptide binding]; other site 869211004545 active site 869211004546 zinc binding site [ion binding]; other site 869211004547 Na+ binding site [ion binding]; other site 869211004548 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 869211004549 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 869211004550 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869211004551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211004552 S-adenosylmethionine binding site [chemical binding]; other site 869211004553 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869211004554 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869211004555 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869211004556 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869211004557 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869211004558 23S rRNA binding site [nucleotide binding]; other site 869211004559 L21 binding site [polypeptide binding]; other site 869211004560 L13 binding site [polypeptide binding]; other site 869211004561 Cell division protein ZapA; Region: ZapA; pfam05164 869211004562 PilZ domain; Region: PilZ; pfam07238 869211004563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004564 binding surface 869211004565 TPR repeat; Region: TPR_11; pfam13414 869211004566 TPR motif; other site 869211004567 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211004568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004569 binding surface 869211004570 TPR motif; other site 869211004571 flagellin; Provisional; Region: PRK12804 869211004572 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869211004573 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 869211004574 flagellin; Provisional; Region: PRK12804 869211004575 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869211004576 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 869211004577 FlaG protein; Region: FlaG; pfam03646 869211004578 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 869211004579 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 869211004580 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 869211004581 PilZ domain; Region: PilZ; pfam07238 869211004582 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 869211004583 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 869211004584 Glycoprotease family; Region: Peptidase_M22; pfam00814 869211004585 carbon storage regulator; Provisional; Region: PRK01712 869211004586 flagellar assembly protein FliW; Provisional; Region: PRK13285 869211004587 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 869211004588 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869211004589 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869211004590 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 869211004591 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869211004592 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869211004593 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869211004594 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869211004595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869211004596 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 869211004597 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869211004598 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869211004599 glycogen synthase; Provisional; Region: glgA; PRK00654 869211004600 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 869211004601 ADP-binding pocket [chemical binding]; other site 869211004602 homodimer interface [polypeptide binding]; other site 869211004603 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 869211004604 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 869211004605 ligand binding site; other site 869211004606 oligomer interface; other site 869211004607 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211004608 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869211004609 dimer interface [polypeptide binding]; other site 869211004610 N-terminal domain interface [polypeptide binding]; other site 869211004611 sulfate 1 binding site; other site 869211004612 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 869211004613 active site 869211004614 8-oxo-dGMP binding site [chemical binding]; other site 869211004615 nudix motif; other site 869211004616 metal binding site [ion binding]; metal-binding site 869211004617 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 869211004618 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869211004619 putative substrate binding site [chemical binding]; other site 869211004620 putative ATP binding site [chemical binding]; other site 869211004621 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869211004622 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869211004623 SEC-C motif; Region: SEC-C; pfam02810 869211004624 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211004625 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869211004626 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211004627 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211004628 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869211004629 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869211004630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869211004631 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 869211004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 869211004633 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869211004634 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869211004635 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869211004636 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869211004637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869211004638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869211004639 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869211004640 IMP binding site; other site 869211004641 dimer interface [polypeptide binding]; other site 869211004642 interdomain contacts; other site 869211004643 partial ornithine binding site; other site 869211004644 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869211004645 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 869211004646 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869211004647 catalytic site [active] 869211004648 subunit interface [polypeptide binding]; other site 869211004649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869211004650 active site 869211004651 UGMP family protein; Validated; Region: PRK09604 869211004652 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 869211004653 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 869211004654 NodB motif; other site 869211004655 putative active site [active] 869211004656 putative catalytic site [active] 869211004657 Zn binding site [ion binding]; other site 869211004658 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869211004659 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 869211004660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211004661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869211004662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211004663 DNA binding residues [nucleotide binding] 869211004664 Rod binding protein; Region: Rod-binding; cl01626 869211004665 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 869211004666 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869211004667 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869211004668 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 869211004669 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869211004670 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869211004671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869211004672 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 869211004673 ligand binding site [chemical binding]; other site 869211004674 flexible hinge region; other site 869211004675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 869211004676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869211004677 ligand binding site [chemical binding]; other site 869211004678 flexible hinge region; other site 869211004679 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 869211004680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004681 binding surface 869211004682 TPR motif; other site 869211004683 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 869211004684 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 869211004685 active site 869211004686 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 869211004687 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 869211004688 Permease; Region: Permease; pfam02405 869211004689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211004690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211004691 Walker A/P-loop; other site 869211004692 ATP binding site [chemical binding]; other site 869211004693 Q-loop/lid; other site 869211004694 ABC transporter signature motif; other site 869211004695 Walker B; other site 869211004696 D-loop; other site 869211004697 H-loop/switch region; other site 869211004698 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 869211004699 mce related protein; Region: MCE; pfam02470 869211004700 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 869211004701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869211004702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211004703 binding surface 869211004704 TPR motif; other site 869211004705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869211004706 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869211004707 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211004708 PEGA domain; Region: PEGA; pfam08308 869211004709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211004710 S-adenosylmethionine binding site [chemical binding]; other site 869211004711 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 869211004712 Transglycosylase; Region: Transgly; pfam00912 869211004713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869211004714 ParB-like nuclease domain; Region: ParB; smart00470 869211004715 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 869211004716 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869211004717 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869211004718 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 869211004719 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 869211004720 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 869211004721 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 869211004722 PQQ-like domain; Region: PQQ_2; pfam13360 869211004723 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 869211004724 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869211004725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211004726 putative active site [active] 869211004727 heme pocket [chemical binding]; other site 869211004728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211004729 phosphorylation site [posttranslational modification] 869211004730 dimer interface [polypeptide binding]; other site 869211004731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211004732 ATP binding site [chemical binding]; other site 869211004733 Mg2+ binding site [ion binding]; other site 869211004734 G-X-G motif; other site 869211004735 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869211004736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211004737 active site 869211004738 phosphorylation site [posttranslational modification] 869211004739 intermolecular recognition site; other site 869211004740 dimerization interface [polypeptide binding]; other site 869211004741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211004742 Walker A motif; other site 869211004743 ATP binding site [chemical binding]; other site 869211004744 Walker B motif; other site 869211004745 arginine finger; other site 869211004746 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869211004747 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211004748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211004749 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869211004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004751 conserved gate region; other site 869211004752 dimer interface [polypeptide binding]; other site 869211004753 putative PBP binding loops; other site 869211004754 ABC-ATPase subunit interface; other site 869211004755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211004756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004757 dimer interface [polypeptide binding]; other site 869211004758 conserved gate region; other site 869211004759 putative PBP binding loops; other site 869211004760 ABC-ATPase subunit interface; other site 869211004761 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 869211004762 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 869211004763 active site 869211004764 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 869211004765 Isochorismatase family; Region: Isochorismatase; pfam00857 869211004766 catalytic triad [active] 869211004767 metal binding site [ion binding]; metal-binding site 869211004768 conserved cis-peptide bond; other site 869211004769 von Willebrand factor type A domain; Region: VWA_2; pfam13519 869211004770 metal ion-dependent adhesion site (MIDAS); other site 869211004771 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 869211004772 phosphopeptide binding site; other site 869211004773 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 869211004774 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 869211004775 Catalytic domain of Protein Kinases; Region: PKc; cd00180 869211004776 active site 869211004777 ATP binding site [chemical binding]; other site 869211004778 substrate binding site [chemical binding]; other site 869211004779 activation loop (A-loop); other site 869211004780 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869211004781 active site 869211004782 metal binding site [ion binding]; metal-binding site 869211004783 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869211004784 IHF dimer interface [polypeptide binding]; other site 869211004785 IHF - DNA interface [nucleotide binding]; other site 869211004786 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 869211004787 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 869211004788 phosphopeptide binding site; other site 869211004789 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 869211004790 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869211004791 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 869211004792 ArsC family; Region: ArsC; pfam03960 869211004793 catalytic residue [active] 869211004794 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869211004795 ATP cone domain; Region: ATP-cone; pfam03477 869211004796 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 869211004797 ATP cone domain; Region: ATP-cone; pfam03477 869211004798 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869211004799 effector binding site; other site 869211004800 active site 869211004801 Zn binding site [ion binding]; other site 869211004802 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869211004803 catalytic residues [active] 869211004804 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 869211004805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211004806 FeS/SAM binding site; other site 869211004807 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869211004808 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 869211004809 ATP binding site [chemical binding]; other site 869211004810 Mg2+ binding site [ion binding]; other site 869211004811 G-X-G motif; other site 869211004812 PilZ domain; Region: PilZ; pfam07238 869211004813 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 869211004814 anti sigma factor interaction site; other site 869211004815 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 869211004816 regulatory phosphorylation site [posttranslational modification]; other site 869211004817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211004818 Transposase; Region: HTH_Tnp_1; pfam01527 869211004819 putative transposase OrfB; Reviewed; Region: PHA02517 869211004820 HTH-like domain; Region: HTH_21; pfam13276 869211004821 Integrase core domain; Region: rve; pfam00665 869211004822 Integrase core domain; Region: rve_3; pfam13683 869211004823 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 869211004824 Clp amino terminal domain; Region: Clp_N; pfam02861 869211004825 Clp amino terminal domain; Region: Clp_N; pfam02861 869211004826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211004827 Walker A motif; other site 869211004828 ATP binding site [chemical binding]; other site 869211004829 Walker B motif; other site 869211004830 arginine finger; other site 869211004831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211004832 Walker A motif; other site 869211004833 ATP binding site [chemical binding]; other site 869211004834 Walker B motif; other site 869211004835 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869211004836 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 869211004837 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 869211004838 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 869211004839 catalytic triad [active] 869211004840 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 869211004841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869211004842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211004843 homodimer interface [polypeptide binding]; other site 869211004844 catalytic residue [active] 869211004845 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 869211004846 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 869211004847 PDGLE domain; Region: PDGLE; pfam13190 869211004848 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211004849 MULE transposase domain; Region: MULE; pfam10551 869211004850 LemA family; Region: LemA; pfam04011 869211004851 Repair protein; Region: Repair_PSII; pfam04536 869211004852 Repair protein; Region: Repair_PSII; pfam04536 869211004853 Cupin domain; Region: Cupin_2; pfam07883 869211004854 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869211004855 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 869211004856 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 869211004857 DctM-like transporters; Region: DctM; pfam06808 869211004858 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 869211004859 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 869211004860 metal ion-dependent adhesion site (MIDAS); other site 869211004861 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 869211004862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211004863 Walker A motif; other site 869211004864 ATP binding site [chemical binding]; other site 869211004865 Walker B motif; other site 869211004866 arginine finger; other site 869211004867 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 869211004868 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 869211004869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869211004870 DNA-binding site [nucleotide binding]; DNA binding site 869211004871 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869211004872 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869211004873 Walker A/P-loop; other site 869211004874 ATP binding site [chemical binding]; other site 869211004875 Q-loop/lid; other site 869211004876 ABC transporter signature motif; other site 869211004877 Walker B; other site 869211004878 D-loop; other site 869211004879 H-loop/switch region; other site 869211004880 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 869211004881 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 869211004882 ZIP Zinc transporter; Region: Zip; pfam02535 869211004883 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 869211004884 ribonuclease PH; Reviewed; Region: rph; PRK00173 869211004885 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 869211004886 oligomer interface [polypeptide binding]; other site 869211004887 RNA binding site [nucleotide binding]; other site 869211004888 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 869211004889 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869211004890 Walker A/P-loop; other site 869211004891 ATP binding site [chemical binding]; other site 869211004892 Q-loop/lid; other site 869211004893 ABC transporter signature motif; other site 869211004894 Walker B; other site 869211004895 D-loop; other site 869211004896 H-loop/switch region; other site 869211004897 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 869211004898 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 869211004899 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 869211004900 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 869211004901 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 869211004902 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 869211004903 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 869211004904 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869211004905 catalytic loop [active] 869211004906 iron binding site [ion binding]; other site 869211004907 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 869211004908 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 869211004909 4Fe-4S binding domain; Region: Fer4; pfam00037 869211004910 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 869211004911 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 869211004912 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 869211004913 dimer interface [polypeptide binding]; other site 869211004914 [2Fe-2S] cluster binding site [ion binding]; other site 869211004915 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 869211004916 SLBB domain; Region: SLBB; pfam10531 869211004917 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 869211004918 4Fe-4S binding domain; Region: Fer4; pfam00037 869211004919 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 869211004920 4Fe-4S binding domain; Region: Fer4; pfam00037 869211004921 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 869211004922 dimer interface [polypeptide binding]; other site 869211004923 [2Fe-2S] cluster binding site [ion binding]; other site 869211004924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211004925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211004926 ATP binding site [chemical binding]; other site 869211004927 Mg2+ binding site [ion binding]; other site 869211004928 G-X-G motif; other site 869211004929 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 869211004930 HIRAN domain; Region: HIRAN; cl07418 869211004931 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 869211004932 putative dimer interface [polypeptide binding]; other site 869211004933 [2Fe-2S] cluster binding site [ion binding]; other site 869211004934 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 869211004935 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 869211004936 CoA binding domain; Region: CoA_binding; cl17356 869211004937 DRTGG domain; Region: DRTGG; pfam07085 869211004938 FOG: CBS domain [General function prediction only]; Region: COG0517 869211004939 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 869211004940 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 869211004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211004942 ATP binding site [chemical binding]; other site 869211004943 G-X-G motif; other site 869211004944 DRTGG domain; Region: DRTGG; pfam07085 869211004945 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 869211004946 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 869211004947 active site 869211004948 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 869211004949 PHP-associated; Region: PHP_C; pfam13263 869211004950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211004951 Transposase; Region: HTH_Tnp_1; pfam01527 869211004952 putative transposase OrfB; Reviewed; Region: PHA02517 869211004953 HTH-like domain; Region: HTH_21; pfam13276 869211004954 Integrase core domain; Region: rve; pfam00665 869211004955 Integrase core domain; Region: rve_3; pfam13683 869211004956 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869211004957 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 869211004958 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 869211004959 active site 869211004960 catalytic residues [active] 869211004961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211004962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211004963 DNA binding site [nucleotide binding] 869211004964 domain linker motif; other site 869211004965 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211004966 ligand binding site [chemical binding]; other site 869211004967 dimerization interface [polypeptide binding]; other site 869211004968 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 869211004969 active site 869211004970 catalytic residues [active] 869211004971 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211004972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211004973 DNA binding site [nucleotide binding] 869211004974 domain linker motif; other site 869211004975 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211004976 dimerization interface [polypeptide binding]; other site 869211004977 ligand binding site [chemical binding]; other site 869211004978 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211004979 MULE transposase domain; Region: MULE; pfam10551 869211004980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211004981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004982 dimer interface [polypeptide binding]; other site 869211004983 conserved gate region; other site 869211004984 putative PBP binding loops; other site 869211004985 ABC-ATPase subunit interface; other site 869211004986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211004987 dimer interface [polypeptide binding]; other site 869211004988 conserved gate region; other site 869211004989 putative PBP binding loops; other site 869211004990 ABC-ATPase subunit interface; other site 869211004991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211004992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211004993 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 869211004994 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 869211004995 Probable beta-xylosidase; Provisional; Region: PLN03080 869211004996 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869211004997 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 869211004998 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 869211004999 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 869211005000 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 869211005001 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869211005002 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869211005003 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 869211005004 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 869211005005 NAD binding site [chemical binding]; other site 869211005006 sugar binding site [chemical binding]; other site 869211005007 divalent metal binding site [ion binding]; other site 869211005008 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 869211005009 dimer interface [polypeptide binding]; other site 869211005010 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 869211005011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211005012 S-adenosylmethionine binding site [chemical binding]; other site 869211005013 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869211005014 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869211005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211005016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869211005017 putative substrate translocation pore; other site 869211005018 HEAT repeats; Region: HEAT_2; pfam13646 869211005019 Peptidase family M48; Region: Peptidase_M48; cl12018 869211005020 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 869211005021 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 869211005022 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869211005023 active site 869211005024 HIGH motif; other site 869211005025 nucleotide binding site [chemical binding]; other site 869211005026 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 869211005027 KMSKS motif; other site 869211005028 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 869211005029 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869211005030 human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339 869211005031 putative NAD(P) binding site [chemical binding]; other site 869211005032 homodimer interface [polypeptide binding]; other site 869211005033 active site 869211005034 substrate binding site [chemical binding]; other site 869211005035 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 869211005036 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 869211005037 NAD(P) binding site [chemical binding]; other site 869211005038 catalytic residues [active] 869211005039 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 869211005040 Part of AAA domain; Region: AAA_19; pfam13245 869211005041 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 869211005042 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 869211005043 Family description; Region: UvrD_C_2; pfam13538 869211005044 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 869211005045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211005046 Zn2+ binding site [ion binding]; other site 869211005047 Mg2+ binding site [ion binding]; other site 869211005048 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 869211005049 Cache domain; Region: Cache_1; pfam02743 869211005050 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211005051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211005052 metal binding site [ion binding]; metal-binding site 869211005053 active site 869211005054 I-site; other site 869211005055 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 869211005056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869211005057 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869211005058 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 869211005059 acyl-activating enzyme (AAE) consensus motif; other site 869211005060 acyl-activating enzyme (AAE) consensus motif; other site 869211005061 putative AMP binding site [chemical binding]; other site 869211005062 putative active site [active] 869211005063 putative CoA binding site [chemical binding]; other site 869211005064 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 869211005065 PAS fold; Region: PAS_3; pfam08447 869211005066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211005067 metal binding site [ion binding]; metal-binding site 869211005068 active site 869211005069 I-site; other site 869211005070 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869211005071 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211005072 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211005073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211005074 Transposase; Region: HTH_Tnp_1; cl17663 869211005075 putative transposase OrfB; Reviewed; Region: PHA02517 869211005076 HTH-like domain; Region: HTH_21; pfam13276 869211005077 Integrase core domain; Region: rve; pfam00665 869211005078 Integrase core domain; Region: rve_3; pfam13683 869211005079 Homeodomain-like domain; Region: HTH_23; pfam13384 869211005080 Winged helix-turn helix; Region: HTH_29; pfam13551 869211005081 Homeodomain-like domain; Region: HTH_32; pfam13565 869211005082 Integrase core domain; Region: rve; pfam00665 869211005083 HEPN domain; Region: HEPN; pfam05168 869211005084 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005085 active site 869211005086 NTP binding site [chemical binding]; other site 869211005087 metal binding triad [ion binding]; metal-binding site 869211005088 antibiotic binding site [chemical binding]; other site 869211005089 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869211005090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211005091 Walker A/P-loop; other site 869211005092 ATP binding site [chemical binding]; other site 869211005093 Q-loop/lid; other site 869211005094 ABC transporter signature motif; other site 869211005095 Walker B; other site 869211005096 D-loop; other site 869211005097 H-loop/switch region; other site 869211005098 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869211005099 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 869211005100 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 869211005101 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869211005102 sugar binding site [chemical binding]; other site 869211005103 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 869211005104 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_3; cd11575 869211005105 putative ligand binding site [chemical binding]; other site 869211005106 putative catalytic site [active] 869211005107 beta-phosphoglucomutase; Region: bPGM; TIGR01990 869211005108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211005109 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 869211005110 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 869211005111 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 869211005112 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 869211005113 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 869211005114 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 869211005115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211005116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211005117 dimer interface [polypeptide binding]; other site 869211005118 conserved gate region; other site 869211005119 putative PBP binding loops; other site 869211005120 ABC-ATPase subunit interface; other site 869211005121 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211005122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211005123 dimer interface [polypeptide binding]; other site 869211005124 conserved gate region; other site 869211005125 putative PBP binding loops; other site 869211005126 ABC-ATPase subunit interface; other site 869211005127 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211005128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869211005129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211005130 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 869211005131 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869211005132 sugar binding site [chemical binding]; other site 869211005133 CARDB; Region: CARDB; pfam07705 869211005134 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 869211005135 putative metal binding site [ion binding]; other site 869211005136 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 869211005137 putative metal binding site [ion binding]; other site 869211005138 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 869211005139 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 869211005140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211005141 binding surface 869211005142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211005143 TPR motif; other site 869211005144 cytoskeletal protein RodZ; Provisional; Region: PRK10856 869211005145 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 869211005146 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 869211005147 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 869211005148 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 869211005149 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869211005150 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869211005151 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 869211005152 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 869211005153 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869211005154 Walker A motif; other site 869211005155 ATP binding site [chemical binding]; other site 869211005156 Walker B motif; other site 869211005157 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869211005158 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 869211005159 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 869211005160 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211005161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211005162 dimer interface [polypeptide binding]; other site 869211005163 putative CheW interface [polypeptide binding]; other site 869211005164 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211005165 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211005166 DNA binding site [nucleotide binding] 869211005167 domain linker motif; other site 869211005168 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211005169 dimerization interface [polypeptide binding]; other site 869211005170 ligand binding site [chemical binding]; other site 869211005171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211005172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211005173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211005174 Transposase; Region: HTH_Tnp_1; pfam01527 869211005175 putative transposase OrfB; Reviewed; Region: PHA02517 869211005176 HTH-like domain; Region: HTH_21; pfam13276 869211005177 Integrase core domain; Region: rve; pfam00665 869211005178 Integrase core domain; Region: rve_3; pfam13683 869211005179 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 869211005180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869211005181 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 869211005182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211005183 S-adenosylmethionine binding site [chemical binding]; other site 869211005184 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 869211005185 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 869211005186 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 869211005187 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 869211005188 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 869211005189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 869211005190 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211005191 MULE transposase domain; Region: MULE; pfam10551 869211005192 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005193 active site 869211005194 NTP binding site [chemical binding]; other site 869211005195 metal binding triad [ion binding]; metal-binding site 869211005196 antibiotic binding site [chemical binding]; other site 869211005197 Uncharacterized conserved protein [Function unknown]; Region: COG2361 869211005198 MarC family integral membrane protein; Region: MarC; cl00919 869211005199 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005200 active site 869211005201 NTP binding site [chemical binding]; other site 869211005202 metal binding triad [ion binding]; metal-binding site 869211005203 antibiotic binding site [chemical binding]; other site 869211005204 HEPN domain; Region: HEPN; pfam05168 869211005205 MarC family integral membrane protein; Region: MarC; cl00919 869211005206 HEPN domain; Region: HEPN; pfam05168 869211005207 HEPN domain; Region: HEPN; pfam05168 869211005208 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005209 active site 869211005210 NTP binding site [chemical binding]; other site 869211005211 metal binding triad [ion binding]; metal-binding site 869211005212 antibiotic binding site [chemical binding]; other site 869211005213 Uncharacterized conserved protein [Function unknown]; Region: COG2006 869211005214 Domain of unknown function (DUF362); Region: DUF362; pfam04015 869211005215 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 869211005216 4Fe-4S binding domain; Region: Fer4; pfam00037 869211005217 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 869211005218 4Fe-4S binding domain; Region: Fer4; pfam00037 869211005219 LicD family; Region: LicD; pfam04991 869211005220 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 869211005221 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869211005222 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869211005223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869211005224 active site 869211005225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211005226 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 869211005227 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 869211005228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005230 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 869211005231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005232 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 869211005233 putative ADP-binding pocket [chemical binding]; other site 869211005234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005235 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 869211005236 putative ADP-binding pocket [chemical binding]; other site 869211005237 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869211005238 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 869211005239 metal-binding site 869211005240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005241 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 869211005242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869211005243 active site 869211005244 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 869211005245 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 869211005246 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 869211005247 FMN binding site [chemical binding]; other site 869211005248 dimer interface [polypeptide binding]; other site 869211005249 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 869211005250 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869211005251 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 869211005252 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 869211005253 NADP binding site [chemical binding]; other site 869211005254 active site 869211005255 putative substrate binding site [chemical binding]; other site 869211005256 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 869211005257 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 869211005258 NADP-binding site; other site 869211005259 homotetramer interface [polypeptide binding]; other site 869211005260 substrate binding site [chemical binding]; other site 869211005261 homodimer interface [polypeptide binding]; other site 869211005262 active site 869211005263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211005265 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]; Region: COG2250 869211005266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211005267 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869211005268 NAD(P) binding site [chemical binding]; other site 869211005269 active site 869211005270 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 869211005271 Bacterial sugar transferase; Region: Bac_transf; pfam02397 869211005272 Uncharacterized conserved protein [Function unknown]; Region: COG2361 869211005273 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005274 active site 869211005275 NTP binding site [chemical binding]; other site 869211005276 metal binding triad [ion binding]; metal-binding site 869211005277 antibiotic binding site [chemical binding]; other site 869211005278 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869211005279 active site 869211005280 NTP binding site [chemical binding]; other site 869211005281 metal binding triad [ion binding]; metal-binding site 869211005282 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869211005283 histidyl-tRNA synthetase; Region: hisS; TIGR00442 869211005284 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869211005285 dimer interface [polypeptide binding]; other site 869211005286 motif 1; other site 869211005287 active site 869211005288 motif 2; other site 869211005289 motif 3; other site 869211005290 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869211005291 anticodon binding site; other site 869211005292 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 869211005293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211005294 ATP binding site [chemical binding]; other site 869211005295 putative Mg++ binding site [ion binding]; other site 869211005296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869211005297 nucleotide binding region [chemical binding]; other site 869211005298 ATP-binding site [chemical binding]; other site 869211005299 Helicase associated domain (HA2); Region: HA2; pfam04408 869211005300 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 869211005301 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869211005302 active site 869211005303 dimer interface [polypeptide binding]; other site 869211005304 metal binding site [ion binding]; metal-binding site 869211005305 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 869211005306 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 869211005307 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 869211005308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211005309 dimerization interface [polypeptide binding]; other site 869211005310 putative DNA binding site [nucleotide binding]; other site 869211005311 putative Zn2+ binding site [ion binding]; other site 869211005312 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869211005313 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869211005314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869211005315 catalytic residue [active] 869211005316 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 869211005317 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869211005318 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869211005319 Ligand Binding Site [chemical binding]; other site 869211005320 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 869211005321 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 869211005322 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 869211005323 substrate binding site [chemical binding]; other site 869211005324 glutamase interaction surface [polypeptide binding]; other site 869211005325 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 869211005326 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 869211005327 putative active site [active] 869211005328 oxyanion strand; other site 869211005329 catalytic triad [active] 869211005330 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 869211005331 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869211005332 HIGH motif; other site 869211005333 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869211005334 active site 869211005335 KMSKS motif; other site 869211005336 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 869211005337 tRNA binding surface [nucleotide binding]; other site 869211005338 anticodon binding site; other site 869211005339 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 869211005340 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869211005341 NADP binding site [chemical binding]; other site 869211005342 homodimer interface [polypeptide binding]; other site 869211005343 active site 869211005344 Transcriptional regulators [Transcription]; Region: GntR; COG1802 869211005345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869211005346 DNA-binding site [nucleotide binding]; DNA binding site 869211005347 FCD domain; Region: FCD; pfam07729 869211005348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869211005349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869211005350 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869211005351 DctM-like transporters; Region: DctM; pfam06808 869211005352 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 869211005353 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211005354 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211005355 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 869211005356 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869211005357 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 869211005358 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 869211005359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869211005360 Coenzyme A binding pocket [chemical binding]; other site 869211005361 Uncharacterized conserved protein [Function unknown]; Region: COG1543 869211005362 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 869211005363 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 869211005364 putative active site [active] 869211005365 catalytic site [active] 869211005366 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 869211005367 putative ligand binding site [chemical binding]; other site 869211005368 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 869211005369 glycogen binding site [chemical binding]; other site 869211005370 alpha-amylase; Region: PLN02361 869211005371 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 869211005372 active site 869211005373 Ca binding site [ion binding]; other site 869211005374 catalytic site [active] 869211005375 Alpha-amylase C-terminal beta-sheet domain; Region: Alpha-amyl_C2; pfam07821 869211005376 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211005377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211005378 dimer interface [polypeptide binding]; other site 869211005379 putative CheW interface [polypeptide binding]; other site 869211005380 WGR domain; Region: WGR; cl01581 869211005381 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 869211005382 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 869211005383 active site 869211005384 Zn binding site [ion binding]; other site 869211005385 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 869211005386 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869211005387 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869211005388 active site 869211005389 dimer interface [polypeptide binding]; other site 869211005390 motif 1; other site 869211005391 motif 2; other site 869211005392 motif 3; other site 869211005393 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869211005394 anticodon binding site; other site 869211005395 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 869211005396 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 869211005397 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 869211005398 hypothetical protein; Reviewed; Region: PRK09588 869211005399 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 869211005400 putative ligand binding pocket/active site [active] 869211005401 putative metal binding site [ion binding]; other site 869211005402 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 869211005403 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 869211005404 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869211005405 Walker A/P-loop; other site 869211005406 ATP binding site [chemical binding]; other site 869211005407 Q-loop/lid; other site 869211005408 ABC transporter signature motif; other site 869211005409 Walker B; other site 869211005410 D-loop; other site 869211005411 H-loop/switch region; other site 869211005412 ribonuclease Z; Region: RNase_Z; TIGR02651 869211005413 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 869211005414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869211005415 inhibitor-cofactor binding pocket; inhibition site 869211005416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211005417 catalytic residue [active] 869211005418 Delta-aminolevulinic acid dehydratase; Region: ALAD; pfam00490 869211005419 dimer interface [polypeptide binding]; other site 869211005420 active site 869211005421 Schiff base residues; other site 869211005422 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 869211005423 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 869211005424 active site 869211005425 domain interfaces; other site 869211005426 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 869211005427 active site 869211005428 SAM binding site [chemical binding]; other site 869211005429 homodimer interface [polypeptide binding]; other site 869211005430 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 869211005431 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 869211005432 active site 869211005433 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 869211005434 NAD(P) binding pocket [chemical binding]; other site 869211005435 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 869211005436 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 869211005437 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 869211005438 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 869211005439 G1 box; other site 869211005440 putative GEF interaction site [polypeptide binding]; other site 869211005441 GTP/Mg2+ binding site [chemical binding]; other site 869211005442 Switch I region; other site 869211005443 G2 box; other site 869211005444 CysD dimerization site [polypeptide binding]; other site 869211005445 G3 box; other site 869211005446 Switch II region; other site 869211005447 G4 box; other site 869211005448 G5 box; other site 869211005449 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 869211005450 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 869211005451 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869211005452 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 869211005453 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 869211005454 Active Sites [active] 869211005455 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 869211005456 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 869211005457 Active Sites [active] 869211005458 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 869211005459 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 869211005460 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 869211005461 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 869211005462 HEPN domain; Region: HEPN; cl00824 869211005463 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 869211005464 CPxP motif; other site 869211005465 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 869211005466 MPN+ (JAMM) motif; other site 869211005467 Zinc-binding site [ion binding]; other site 869211005468 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 869211005469 CPxP motif; other site 869211005470 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 869211005471 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 869211005472 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 869211005473 ATP binding site [chemical binding]; other site 869211005474 substrate interface [chemical binding]; other site 869211005475 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 869211005476 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869211005477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869211005478 catalytic residue [active] 869211005479 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 869211005480 thiS-thiF/thiG interaction site; other site 869211005481 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 869211005482 non-specific DNA interactions [nucleotide binding]; other site 869211005483 DNA binding site [nucleotide binding] 869211005484 sequence specific DNA binding site [nucleotide binding]; other site 869211005485 putative cAMP binding site [chemical binding]; other site 869211005486 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869211005487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211005488 xylose isomerase; Provisional; Region: PRK05474 869211005489 xylose isomerase; Region: xylose_isom_A; TIGR02630 869211005490 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 869211005491 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 869211005492 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 869211005493 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 869211005494 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 869211005495 HflK protein; Region: hflK; TIGR01933 869211005496 HflC protein; Region: hflC; TIGR01932 869211005497 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 869211005498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211005499 I-site; other site 869211005500 metal binding site [ion binding]; metal-binding site 869211005501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869211005502 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869211005503 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 869211005504 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 869211005505 Putative Fe-S cluster; Region: FeS; cl17515 869211005506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211005507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211005508 dimer interface [polypeptide binding]; other site 869211005509 putative CheW interface [polypeptide binding]; other site 869211005510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869211005511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869211005512 active site 869211005513 catalytic tetrad [active] 869211005514 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869211005515 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 869211005516 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869211005517 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 869211005518 Recombination protein O N terminal; Region: RecO_N; pfam11967 869211005519 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 869211005520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211005521 Walker A motif; other site 869211005522 ATP binding site [chemical binding]; other site 869211005523 Walker B motif; other site 869211005524 arginine finger; other site 869211005525 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 869211005526 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 869211005527 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869211005528 Peptidase family U32; Region: Peptidase_U32; pfam01136 869211005529 Domain of unknown function (DUF303); Region: DUF303; pfam03629 869211005530 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869211005531 Domain of unknown function (DUF303); Region: DUF303; pfam03629 869211005532 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869211005533 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 869211005534 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 869211005535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869211005536 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 869211005537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869211005538 dimerization interface [polypeptide binding]; other site 869211005539 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 869211005540 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869211005541 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869211005542 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869211005543 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 869211005544 dimer interface [polypeptide binding]; other site 869211005545 substrate binding site [chemical binding]; other site 869211005546 metal binding site [ion binding]; metal-binding site 869211005547 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 869211005548 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 869211005549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211005550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211005551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211005552 PAS domain; Region: PAS_9; pfam13426 869211005553 putative active site [active] 869211005554 heme pocket [chemical binding]; other site 869211005555 PAS fold; Region: PAS_4; pfam08448 869211005556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869211005557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211005558 dimer interface [polypeptide binding]; other site 869211005559 phosphorylation site [posttranslational modification] 869211005560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211005561 ATP binding site [chemical binding]; other site 869211005562 Mg2+ binding site [ion binding]; other site 869211005563 G-X-G motif; other site 869211005564 Response regulator receiver domain; Region: Response_reg; pfam00072 869211005565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211005566 active site 869211005567 phosphorylation site [posttranslational modification] 869211005568 intermolecular recognition site; other site 869211005569 dimerization interface [polypeptide binding]; other site 869211005570 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 869211005571 putative binding surface; other site 869211005572 active site 869211005573 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; pfam02544 869211005574 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 869211005575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211005576 NAD(P) binding site [chemical binding]; other site 869211005577 active site 869211005578 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 869211005579 putative active site; other site 869211005580 signature motif; other site 869211005581 putative triphosphate binding site [ion binding]; other site 869211005582 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 869211005583 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 869211005584 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 869211005585 putative active site [active] 869211005586 putative substrate binding site [chemical binding]; other site 869211005587 putative cosubstrate binding site; other site 869211005588 catalytic site [active] 869211005589 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 869211005590 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 869211005591 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 869211005592 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211005593 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 869211005594 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 869211005595 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869211005596 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 869211005597 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869211005598 ligand binding site [chemical binding]; other site 869211005599 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 869211005600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005601 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 869211005602 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 869211005603 dimer interface [polypeptide binding]; other site 869211005604 PYR/PP interface [polypeptide binding]; other site 869211005605 TPP binding site [chemical binding]; other site 869211005606 substrate binding site [chemical binding]; other site 869211005607 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 869211005608 Domain of unknown function; Region: EKR; smart00890 869211005609 4Fe-4S binding domain; Region: Fer4_6; pfam12837 869211005610 4Fe-4S binding domain; Region: Fer4; pfam00037 869211005611 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 869211005612 TPP-binding site [chemical binding]; other site 869211005613 dimer interface [polypeptide binding]; other site 869211005614 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 869211005615 PilZ domain; Region: PilZ; pfam07238 869211005616 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869211005617 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869211005618 substrate binding site [chemical binding]; other site 869211005619 hexamer interface [polypeptide binding]; other site 869211005620 metal binding site [ion binding]; metal-binding site 869211005621 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869211005622 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869211005623 active site 869211005624 dimer interface [polypeptide binding]; other site 869211005625 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869211005626 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869211005627 THF binding site; other site 869211005628 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869211005629 substrate binding site [chemical binding]; other site 869211005630 THF binding site; other site 869211005631 zinc-binding site [ion binding]; other site 869211005632 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 869211005633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869211005634 putative Mg++ binding site [ion binding]; other site 869211005635 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 869211005636 RNA binding site [nucleotide binding]; other site 869211005637 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869211005638 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 869211005639 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869211005640 rRNA binding site [nucleotide binding]; other site 869211005641 predicted 30S ribosome binding site; other site 869211005642 Smr domain; Region: Smr; pfam01713 869211005643 Oxygen tolerance; Region: BatD; pfam13584 869211005644 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211005645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869211005646 TPR motif; other site 869211005647 binding surface 869211005648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211005649 binding surface 869211005650 TPR motif; other site 869211005651 TPR repeat; Region: TPR_11; pfam13414 869211005652 von Willebrand factor type A domain; Region: VWA_2; pfam13519 869211005653 metal ion-dependent adhesion site (MIDAS); other site 869211005654 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 869211005655 metal ion-dependent adhesion site (MIDAS); other site 869211005656 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 869211005657 Protein of unknown function DUF58; Region: DUF58; pfam01882 869211005658 MoxR-like ATPases [General function prediction only]; Region: COG0714 869211005659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211005660 Walker A motif; other site 869211005661 ATP binding site [chemical binding]; other site 869211005662 Walker B motif; other site 869211005663 arginine finger; other site 869211005664 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 869211005665 heterotetramer interface [polypeptide binding]; other site 869211005666 active site pocket [active] 869211005667 cleavage site 869211005668 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211005669 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211005670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211005671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211005672 dimer interface [polypeptide binding]; other site 869211005673 conserved gate region; other site 869211005674 putative PBP binding loops; other site 869211005675 ABC-ATPase subunit interface; other site 869211005676 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869211005677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869211005678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211005679 conserved gate region; other site 869211005680 dimer interface [polypeptide binding]; other site 869211005681 putative PBP binding loops; other site 869211005682 ABC-ATPase subunit interface; other site 869211005683 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 869211005684 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 869211005685 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 869211005686 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 869211005687 short chain dehydrogenase; Provisional; Region: PRK06841 869211005688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211005689 NAD(P) binding site [chemical binding]; other site 869211005690 active site 869211005691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869211005692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211005693 DNA binding site [nucleotide binding] 869211005694 domain linker motif; other site 869211005695 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869211005696 ligand binding site [chemical binding]; other site 869211005697 dimerization interface [polypeptide binding]; other site 869211005698 Alginate lyase; Region: Alginate_lyase2; pfam08787 869211005699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211005700 Transposase; Region: HTH_Tnp_1; pfam01527 869211005701 putative transposase OrfB; Reviewed; Region: PHA02517 869211005702 HTH-like domain; Region: HTH_21; pfam13276 869211005703 Integrase core domain; Region: rve; pfam00665 869211005704 Integrase core domain; Region: rve_3; pfam13683 869211005705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211005706 Transposase; Region: HTH_Tnp_1; pfam01527 869211005707 putative transposase OrfB; Reviewed; Region: PHA02517 869211005708 HTH-like domain; Region: HTH_21; pfam13276 869211005709 Integrase core domain; Region: rve; pfam00665 869211005710 Integrase core domain; Region: rve_3; pfam13683 869211005711 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 869211005712 histidinol-phosphatase; Provisional; Region: PRK07328 869211005713 active site 869211005714 dimer interface [polypeptide binding]; other site 869211005715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869211005716 catalytic core [active] 869211005717 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 869211005718 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 869211005719 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869211005720 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869211005721 Walker A/P-loop; other site 869211005722 ATP binding site [chemical binding]; other site 869211005723 Q-loop/lid; other site 869211005724 ABC transporter signature motif; other site 869211005725 Walker B; other site 869211005726 D-loop; other site 869211005727 H-loop/switch region; other site 869211005728 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 869211005729 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 869211005730 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 869211005731 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 869211005732 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 869211005733 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 869211005734 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 869211005735 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005736 active site 869211005737 NTP binding site [chemical binding]; other site 869211005738 metal binding triad [ion binding]; metal-binding site 869211005739 HEPN domain; Region: HEPN; pfam05168 869211005740 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869211005741 MutS domain III; Region: MutS_III; pfam05192 869211005742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211005743 Walker A/P-loop; other site 869211005744 ATP binding site [chemical binding]; other site 869211005745 Q-loop/lid; other site 869211005746 ABC transporter signature motif; other site 869211005747 Walker B; other site 869211005748 D-loop; other site 869211005749 H-loop/switch region; other site 869211005750 Smr domain; Region: Smr; pfam01713 869211005751 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 869211005752 PEGA domain; Region: PEGA; pfam08308 869211005753 PEGA domain; Region: PEGA; pfam08308 869211005754 GTPase RsgA; Reviewed; Region: PRK00098 869211005755 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 869211005756 RNA binding site [nucleotide binding]; other site 869211005757 homodimer interface [polypeptide binding]; other site 869211005758 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869211005759 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869211005760 GTP/Mg2+ binding site [chemical binding]; other site 869211005761 G4 box; other site 869211005762 G5 box; other site 869211005763 G1 box; other site 869211005764 Switch I region; other site 869211005765 G2 box; other site 869211005766 G3 box; other site 869211005767 Switch II region; other site 869211005768 glutamate racemase; Provisional; Region: PRK00865 869211005769 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 869211005770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869211005771 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869211005772 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869211005773 active site 869211005774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869211005775 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869211005776 catalytic residue [active] 869211005777 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 869211005778 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 869211005779 active site 869211005780 multimer interface [polypeptide binding]; other site 869211005781 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 869211005782 predicted active site [active] 869211005783 catalytic triad [active] 869211005784 LytB protein; Region: LYTB; cl00507 869211005785 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869211005786 substrate binding pocket [chemical binding]; other site 869211005787 chain length determination region; other site 869211005788 substrate-Mg2+ binding site; other site 869211005789 catalytic residues [active] 869211005790 aspartate-rich region 1; other site 869211005791 active site lid residues [active] 869211005792 aspartate-rich region 2; other site 869211005793 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869211005794 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 869211005795 Protein of unknown function (DUF401); Region: DUF401; cl00830 869211005796 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 869211005797 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869211005798 PYR/PP interface [polypeptide binding]; other site 869211005799 dimer interface [polypeptide binding]; other site 869211005800 TPP binding site [chemical binding]; other site 869211005801 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869211005802 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869211005803 TPP-binding site [chemical binding]; other site 869211005804 dimer interface [polypeptide binding]; other site 869211005805 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 869211005806 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869211005807 putative valine binding site [chemical binding]; other site 869211005808 dimer interface [polypeptide binding]; other site 869211005809 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 869211005810 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211005811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211005812 active site 869211005813 phosphorylation site [posttranslational modification] 869211005814 intermolecular recognition site; other site 869211005815 dimerization interface [polypeptide binding]; other site 869211005816 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 869211005817 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 869211005818 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 869211005819 putative CheA interaction surface; other site 869211005820 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 869211005821 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 869211005822 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869211005823 putative binding surface; other site 869211005824 active site 869211005825 P2 response regulator binding domain; Region: P2; pfam07194 869211005826 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 869211005827 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 869211005828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211005829 ATP binding site [chemical binding]; other site 869211005830 Mg2+ binding site [ion binding]; other site 869211005831 G-X-G motif; other site 869211005832 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 869211005833 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 869211005834 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869211005835 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 869211005836 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 869211005837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869211005838 Walker A/P-loop; other site 869211005839 ATP binding site [chemical binding]; other site 869211005840 Q-loop/lid; other site 869211005841 ABC transporter signature motif; other site 869211005842 Walker B; other site 869211005843 D-loop; other site 869211005844 H-loop/switch region; other site 869211005845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869211005846 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869211005847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869211005848 Walker A/P-loop; other site 869211005849 ATP binding site [chemical binding]; other site 869211005850 Q-loop/lid; other site 869211005851 ABC transporter signature motif; other site 869211005852 Walker B; other site 869211005853 D-loop; other site 869211005854 H-loop/switch region; other site 869211005855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869211005856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869211005857 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869211005858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211005859 dimer interface [polypeptide binding]; other site 869211005860 conserved gate region; other site 869211005861 putative PBP binding loops; other site 869211005862 ABC-ATPase subunit interface; other site 869211005863 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869211005864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211005865 dimer interface [polypeptide binding]; other site 869211005866 conserved gate region; other site 869211005867 putative PBP binding loops; other site 869211005868 ABC-ATPase subunit interface; other site 869211005869 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 869211005870 substrate binding site [chemical binding]; other site 869211005871 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869211005872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211005873 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869211005874 putative DNA binding site [nucleotide binding]; other site 869211005875 putative Zn2+ binding site [ion binding]; other site 869211005876 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869211005877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211005878 N-acetylglutamate synthase; Validated; Region: PRK05279 869211005879 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 869211005880 nucleotide binding site [chemical binding]; other site 869211005881 substrate binding site [chemical binding]; other site 869211005882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869211005883 Coenzyme A binding pocket [chemical binding]; other site 869211005884 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869211005885 active site 869211005886 multimer interface [polypeptide binding]; other site 869211005887 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869211005888 active site 869211005889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211005890 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211005891 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869211005892 active site 869211005893 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 869211005894 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869211005895 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869211005896 protein binding site [polypeptide binding]; other site 869211005897 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869211005898 protein binding site [polypeptide binding]; other site 869211005899 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 869211005900 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 869211005901 putative dimer interface [polypeptide binding]; other site 869211005902 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 869211005903 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 869211005904 putative dimer interface [polypeptide binding]; other site 869211005905 oxidoreductase; Validated; Region: PRK05717 869211005906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211005907 NAD(P) binding site [chemical binding]; other site 869211005908 active site 869211005909 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 869211005910 putative nucleotide binding site [chemical binding]; other site 869211005911 putative metal binding site [ion binding]; other site 869211005912 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 869211005913 dinuclear metal binding motif [ion binding]; other site 869211005914 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 869211005915 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 869211005916 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 869211005917 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 869211005918 cyclase homology domain; Region: CHD; cd07302 869211005919 nucleotidyl binding site; other site 869211005920 metal binding site [ion binding]; metal-binding site 869211005921 dimer interface [polypeptide binding]; other site 869211005922 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869211005923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211005924 motif II; other site 869211005925 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 869211005926 active site 869211005927 NTP binding site [chemical binding]; other site 869211005928 metal binding triad [ion binding]; metal-binding site 869211005929 antibiotic binding site [chemical binding]; other site 869211005930 HEPN domain; Region: HEPN; pfam05168 869211005931 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 869211005932 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 869211005933 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 869211005934 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 869211005935 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 869211005936 diphosphate--fructose-6-phosphate 1-phosphotransferase; Region: PFKA_PPi; TIGR02477 869211005937 active site 869211005938 ADP/pyrophosphate binding site [chemical binding]; other site 869211005939 dimerization interface [polypeptide binding]; other site 869211005940 allosteric effector site; other site 869211005941 fructose-1,6-bisphosphate binding site; other site 869211005942 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869211005943 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 869211005944 substrate binding site [chemical binding]; other site 869211005945 ATP binding site [chemical binding]; other site 869211005946 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869211005947 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 869211005948 putative active site [active] 869211005949 metal binding site [ion binding]; metal-binding site 869211005950 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 869211005951 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 869211005952 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 869211005953 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 869211005954 active site 869211005955 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 869211005956 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869211005957 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869211005958 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869211005959 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869211005960 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869211005961 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869211005962 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 869211005963 FMN binding site [chemical binding]; other site 869211005964 dimer interface [polypeptide binding]; other site 869211005965 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869211005966 active site 869211005967 DNA polymerase IV; Validated; Region: PRK02406 869211005968 DNA binding site [nucleotide binding] 869211005969 Membrane transport protein; Region: Mem_trans; cl09117 869211005970 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211005971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211005972 active site 869211005973 phosphorylation site [posttranslational modification] 869211005974 intermolecular recognition site; other site 869211005975 dimerization interface [polypeptide binding]; other site 869211005976 PAS domain S-box; Region: sensory_box; TIGR00229 869211005977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211005978 putative active site [active] 869211005979 heme pocket [chemical binding]; other site 869211005980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211005981 Histidine kinase; Region: HisKA_2; pfam07568 869211005982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211005983 Mg2+ binding site [ion binding]; other site 869211005984 G-X-G motif; other site 869211005985 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 869211005986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869211005987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211005988 homodimer interface [polypeptide binding]; other site 869211005989 catalytic residue [active] 869211005990 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869211005991 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869211005992 putative acyl-acceptor binding pocket; other site 869211005993 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869211005994 Predicted integral membrane protein [Function unknown]; Region: COG5542 869211005995 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 869211005996 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869211005997 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869211005998 Ligand binding site; other site 869211005999 Putative Catalytic site; other site 869211006000 DXD motif; other site 869211006001 Predicted membrane protein [Function unknown]; Region: COG2246 869211006002 GtrA-like protein; Region: GtrA; pfam04138 869211006003 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 869211006004 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869211006005 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 869211006006 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869211006007 phosphate binding site [ion binding]; other site 869211006008 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211006009 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869211006010 TM-ABC transporter signature motif; other site 869211006011 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211006012 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869211006013 TM-ABC transporter signature motif; other site 869211006014 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 869211006015 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869211006016 Walker A/P-loop; other site 869211006017 ATP binding site [chemical binding]; other site 869211006018 Q-loop/lid; other site 869211006019 ABC transporter signature motif; other site 869211006020 Walker B; other site 869211006021 D-loop; other site 869211006022 H-loop/switch region; other site 869211006023 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869211006024 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 869211006025 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 869211006026 ligand binding site [chemical binding]; other site 869211006027 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869211006028 intersubunit interface [polypeptide binding]; other site 869211006029 active site 869211006030 catalytic residue [active] 869211006031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869211006032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869211006033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869211006034 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 869211006035 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 869211006036 NADP binding site [chemical binding]; other site 869211006037 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 869211006038 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869211006039 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 869211006040 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 869211006041 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 869211006042 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869211006043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869211006044 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 869211006045 Bacitracin resistance protein BacA; Region: BacA; cl00858 869211006046 Bacitracin resistance protein BacA; Region: BacA; cl00858 869211006047 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869211006048 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869211006049 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869211006050 catalytic residue [active] 869211006051 Homeodomain-like domain; Region: HTH_23; pfam13384 869211006052 Winged helix-turn helix; Region: HTH_29; pfam13551 869211006053 Homeodomain-like domain; Region: HTH_32; pfam13565 869211006054 Integrase core domain; Region: rve; pfam00665 869211006055 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 869211006056 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869211006057 ligand binding site [chemical binding]; other site 869211006058 flexible hinge region; other site 869211006059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869211006060 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 869211006061 ligand binding site [chemical binding]; other site 869211006062 flexible hinge region; other site 869211006063 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 869211006064 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 869211006065 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 869211006066 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869211006067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869211006068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869211006069 DNA binding residues [nucleotide binding] 869211006070 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 869211006071 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869211006072 active site 869211006073 HIGH motif; other site 869211006074 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869211006075 KMSKS motif; other site 869211006076 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869211006077 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 869211006078 FAD binding domain; Region: FAD_binding_4; pfam01565 869211006079 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869211006080 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 869211006081 PEGA domain; Region: PEGA; pfam08308 869211006082 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869211006083 propionate/acetate kinase; Provisional; Region: PRK12379 869211006084 DJ-1 family protein; Region: not_thiJ; TIGR01383 869211006085 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869211006086 conserved cys residue [active] 869211006087 primosome assembly protein PriA; Validated; Region: PRK05580 869211006088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869211006089 ATP binding site [chemical binding]; other site 869211006090 putative Mg++ binding site [ion binding]; other site 869211006091 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869211006092 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 869211006093 Fe-S cluster binding site [ion binding]; other site 869211006094 active site 869211006095 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869211006096 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869211006097 dimerization interface 3.5A [polypeptide binding]; other site 869211006098 active site 869211006099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 869211006100 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 869211006101 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 869211006102 YbbR-like protein; Region: YbbR; pfam07949 869211006103 Uncharacterized conserved protein [Function unknown]; Region: COG1624 869211006104 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 869211006105 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 869211006106 dihydropteroate synthase; Region: DHPS; TIGR01496 869211006107 substrate binding pocket [chemical binding]; other site 869211006108 dimer interface [polypeptide binding]; other site 869211006109 inhibitor binding site; inhibition site 869211006110 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 869211006111 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 869211006112 TPP-binding site; other site 869211006113 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869211006114 PYR/PP interface [polypeptide binding]; other site 869211006115 dimer interface [polypeptide binding]; other site 869211006116 TPP binding site [chemical binding]; other site 869211006117 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869211006118 antiporter inner membrane protein; Provisional; Region: PRK11670 869211006119 Domain of unknown function DUF59; Region: DUF59; pfam01883 869211006120 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 869211006121 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869211006122 Protein of unknown function (DUF432); Region: DUF432; cl01027 869211006123 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 869211006124 isocitrate dehydrogenase; Validated; Region: PRK07362 869211006125 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869211006126 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869211006127 catalytic residue [active] 869211006128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211006129 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869211006130 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869211006131 diaminopimelate aminotransferase; Provisional; Region: PRK13983 869211006132 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 869211006133 metal binding site [ion binding]; metal-binding site 869211006134 Uncharacterized conserved protein [Function unknown]; Region: COG1739 869211006135 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869211006136 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869211006137 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869211006138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869211006139 DNA-binding site [nucleotide binding]; DNA binding site 869211006140 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 869211006141 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 869211006142 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 869211006143 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 869211006144 inhibitor binding site; inhibition site 869211006145 active site 869211006146 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211006147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006148 dimer interface [polypeptide binding]; other site 869211006149 conserved gate region; other site 869211006150 putative PBP binding loops; other site 869211006151 ABC-ATPase subunit interface; other site 869211006152 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211006153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006154 ABC-ATPase subunit interface; other site 869211006155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211006156 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211006157 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 869211006158 active site 869211006159 dimer interfaces [polypeptide binding]; other site 869211006160 catalytic residues [active] 869211006161 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869211006162 active site 869211006163 dimerization interface [polypeptide binding]; other site 869211006164 oligoendopeptidase F; Region: pepF; TIGR00181 869211006165 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 869211006166 active site 869211006167 Zn binding site [ion binding]; other site 869211006168 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 869211006169 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 869211006170 putative active site [active] 869211006171 catalytic triad [active] 869211006172 putative dimer interface [polypeptide binding]; other site 869211006173 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869211006174 IHF dimer interface [polypeptide binding]; other site 869211006175 IHF - DNA interface [nucleotide binding]; other site 869211006176 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869211006177 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 869211006178 Protein of unknown function (DUF327); Region: DUF327; pfam03885 869211006179 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 869211006180 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869211006181 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211006182 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869211006183 active site 869211006184 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 869211006185 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869211006186 FMN binding site [chemical binding]; other site 869211006187 active site 869211006188 catalytic residues [active] 869211006189 substrate binding site [chemical binding]; other site 869211006190 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869211006191 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869211006192 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869211006193 HSP70 interaction site [polypeptide binding]; other site 869211006194 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869211006195 substrate binding site [polypeptide binding]; other site 869211006196 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 869211006197 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869211006198 Zn binding sites [ion binding]; other site 869211006199 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869211006200 dimer interface [polypeptide binding]; other site 869211006201 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869211006202 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869211006203 nucleotide binding site [chemical binding]; other site 869211006204 NEF interaction site [polypeptide binding]; other site 869211006205 SBD interface [polypeptide binding]; other site 869211006206 GrpE; Region: GrpE; pfam01025 869211006207 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869211006208 dimer interface [polypeptide binding]; other site 869211006209 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869211006210 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 869211006211 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 869211006212 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 869211006213 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 869211006214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211006215 motif II; other site 869211006216 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 869211006217 AIR carboxylase; Region: AIRC; smart01001 869211006218 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 869211006219 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 869211006220 Ligand Binding Site [chemical binding]; other site 869211006221 hypothetical protein; Provisional; Region: PRK04194 869211006222 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 869211006223 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 869211006224 cyclase homology domain; Region: CHD; cd07302 869211006225 nucleotidyl binding site; other site 869211006226 metal binding site [ion binding]; metal-binding site 869211006227 dimer interface [polypeptide binding]; other site 869211006228 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869211006229 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869211006230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211006231 catalytic residue [active] 869211006232 Trp repressor protein; Region: Trp_repressor; cl17266 869211006233 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 869211006234 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 869211006235 active site 869211006236 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 869211006237 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 869211006238 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 869211006239 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 869211006240 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869211006241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211006242 Walker A/P-loop; other site 869211006243 ATP binding site [chemical binding]; other site 869211006244 Q-loop/lid; other site 869211006245 ABC transporter signature motif; other site 869211006246 Walker B; other site 869211006247 D-loop; other site 869211006248 H-loop/switch region; other site 869211006249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211006250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211006251 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869211006252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869211006253 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869211006254 metal binding site 2 [ion binding]; metal-binding site 869211006255 putative DNA binding helix; other site 869211006256 metal binding site 1 [ion binding]; metal-binding site 869211006257 dimer interface [polypeptide binding]; other site 869211006258 structural Zn2+ binding site [ion binding]; other site 869211006259 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869211006260 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869211006261 dimerization interface [polypeptide binding]; other site 869211006262 DPS ferroxidase diiron center [ion binding]; other site 869211006263 ion pore; other site 869211006264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869211006265 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211006266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006267 dimer interface [polypeptide binding]; other site 869211006268 conserved gate region; other site 869211006269 putative PBP binding loops; other site 869211006270 ABC-ATPase subunit interface; other site 869211006271 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869211006272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006273 dimer interface [polypeptide binding]; other site 869211006274 conserved gate region; other site 869211006275 ABC-ATPase subunit interface; other site 869211006276 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869211006277 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869211006278 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869211006279 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 869211006280 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 869211006281 ligand binding site [chemical binding]; other site 869211006282 metal binding site [ion binding]; metal-binding site 869211006283 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 869211006284 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 869211006285 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 869211006286 Prephenate dehydratase; Region: PDT; pfam00800 869211006287 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869211006288 putative L-Phe binding site [chemical binding]; other site 869211006289 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869211006290 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869211006291 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869211006292 catalytic residue [active] 869211006293 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 869211006294 Response regulator receiver domain; Region: Response_reg; pfam00072 869211006295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211006296 active site 869211006297 phosphorylation site [posttranslational modification] 869211006298 intermolecular recognition site; other site 869211006299 dimerization interface [polypeptide binding]; other site 869211006300 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869211006301 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869211006302 peptide binding site [polypeptide binding]; other site 869211006303 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869211006304 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869211006305 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 869211006306 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869211006307 substrate binding site; other site 869211006308 dimer interface; other site 869211006309 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 869211006310 homotrimer interaction site [polypeptide binding]; other site 869211006311 zinc binding site [ion binding]; other site 869211006312 CDP-binding sites; other site 869211006313 41 helicase; Provisional; Region: 41; PHA02542 869211006314 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869211006315 elongation factor G; Reviewed; Region: PRK12740 869211006316 G1 box; other site 869211006317 putative GEF interaction site [polypeptide binding]; other site 869211006318 GTP/Mg2+ binding site [chemical binding]; other site 869211006319 Switch I region; other site 869211006320 G2 box; other site 869211006321 G3 box; other site 869211006322 Switch II region; other site 869211006323 G4 box; other site 869211006324 G5 box; other site 869211006325 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 869211006326 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869211006327 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 869211006328 FOG: CBS domain [General function prediction only]; Region: COG0517 869211006329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 869211006330 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 869211006331 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 869211006332 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 869211006333 Walker A/P-loop; other site 869211006334 ATP binding site [chemical binding]; other site 869211006335 Q-loop/lid; other site 869211006336 ABC transporter signature motif; other site 869211006337 Walker B; other site 869211006338 D-loop; other site 869211006339 H-loop/switch region; other site 869211006340 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 869211006341 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 869211006342 Walker A/P-loop; other site 869211006343 ATP binding site [chemical binding]; other site 869211006344 Q-loop/lid; other site 869211006345 ABC transporter signature motif; other site 869211006346 Walker B; other site 869211006347 D-loop; other site 869211006348 H-loop/switch region; other site 869211006349 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 869211006350 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 869211006351 TM-ABC transporter signature motif; other site 869211006352 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 869211006353 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211006354 TM-ABC transporter signature motif; other site 869211006355 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869211006356 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 869211006357 putative ligand binding site [chemical binding]; other site 869211006358 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 869211006359 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869211006360 active site 869211006361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211006362 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869211006363 TM-ABC transporter signature motif; other site 869211006364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211006365 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869211006366 TM-ABC transporter signature motif; other site 869211006367 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 869211006368 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869211006369 Walker A/P-loop; other site 869211006370 ATP binding site [chemical binding]; other site 869211006371 Q-loop/lid; other site 869211006372 ABC transporter signature motif; other site 869211006373 Walker B; other site 869211006374 D-loop; other site 869211006375 H-loop/switch region; other site 869211006376 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869211006377 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 869211006378 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 869211006379 putative ligand binding site [chemical binding]; other site 869211006380 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 869211006381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869211006382 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869211006383 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869211006384 Walker A/P-loop; other site 869211006385 ATP binding site [chemical binding]; other site 869211006386 Q-loop/lid; other site 869211006387 ABC transporter signature motif; other site 869211006388 Walker B; other site 869211006389 D-loop; other site 869211006390 H-loop/switch region; other site 869211006391 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869211006392 NMT1/THI5 like; Region: NMT1; pfam09084 869211006393 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869211006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006395 ABC-ATPase subunit interface; other site 869211006396 Domain of unknown function DUF77; Region: DUF77; pfam01910 869211006397 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 869211006398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211006399 dimerization interface [polypeptide binding]; other site 869211006400 PAS domain; Region: PAS; smart00091 869211006401 PAS domain S-box; Region: sensory_box; TIGR00229 869211006402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211006403 putative active site [active] 869211006404 heme pocket [chemical binding]; other site 869211006405 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211006406 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211006407 metal binding site [ion binding]; metal-binding site 869211006408 active site 869211006409 I-site; other site 869211006410 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 869211006411 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 869211006412 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869211006413 Peptidase M30; Region: Peptidase_M30; pfam10460 869211006414 Bacterial SH3 domain; Region: SH3_3; pfam08239 869211006415 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869211006416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211006417 Walker A/P-loop; other site 869211006418 ATP binding site [chemical binding]; other site 869211006419 Q-loop/lid; other site 869211006420 ABC transporter signature motif; other site 869211006421 Walker B; other site 869211006422 D-loop; other site 869211006423 H-loop/switch region; other site 869211006424 ABC transporter; Region: ABC_tran_2; pfam12848 869211006425 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869211006426 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869211006427 putative catalytic site [active] 869211006428 putative metal binding site [ion binding]; other site 869211006429 putative phosphate binding site [ion binding]; other site 869211006430 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 869211006431 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869211006432 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869211006433 RF-1 domain; Region: RF-1; pfam00472 869211006434 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869211006435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211006436 S-adenosylmethionine binding site [chemical binding]; other site 869211006437 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869211006438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211006439 Zn2+ binding site [ion binding]; other site 869211006440 Mg2+ binding site [ion binding]; other site 869211006441 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869211006442 synthetase active site [active] 869211006443 NTP binding site [chemical binding]; other site 869211006444 metal binding site [ion binding]; metal-binding site 869211006445 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869211006446 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869211006447 dimer interface [polypeptide binding]; other site 869211006448 catalytic triad [active] 869211006449 peroxidatic and resolving cysteines [active] 869211006450 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211006451 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869211006452 FtsX-like permease family; Region: FtsX; pfam02687 869211006453 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211006454 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869211006455 FtsX-like permease family; Region: FtsX; pfam02687 869211006456 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211006457 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869211006458 Walker A/P-loop; other site 869211006459 ATP binding site [chemical binding]; other site 869211006460 Q-loop/lid; other site 869211006461 ABC transporter signature motif; other site 869211006462 Walker B; other site 869211006463 D-loop; other site 869211006464 H-loop/switch region; other site 869211006465 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 869211006466 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869211006467 HlyD family secretion protein; Region: HlyD_3; pfam13437 869211006468 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 869211006469 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 869211006470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211006471 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 869211006472 putative active site [active] 869211006473 heme pocket [chemical binding]; other site 869211006474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869211006475 putative active site [active] 869211006476 heme pocket [chemical binding]; other site 869211006477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211006478 Histidine kinase; Region: HisKA_2; pfam07568 869211006479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211006480 ATP binding site [chemical binding]; other site 869211006481 Mg2+ binding site [ion binding]; other site 869211006482 G-X-G motif; other site 869211006483 Response regulator receiver domain; Region: Response_reg; pfam00072 869211006484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211006485 active site 869211006486 phosphorylation site [posttranslational modification] 869211006487 intermolecular recognition site; other site 869211006488 dimerization interface [polypeptide binding]; other site 869211006489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211006490 dimer interface [polypeptide binding]; other site 869211006491 phosphorylation site [posttranslational modification] 869211006492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211006493 ATP binding site [chemical binding]; other site 869211006494 Mg2+ binding site [ion binding]; other site 869211006495 G-X-G motif; other site 869211006496 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 869211006497 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 869211006498 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 869211006499 seryl-tRNA synthetase; Provisional; Region: PRK05431 869211006500 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869211006501 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869211006502 dimer interface [polypeptide binding]; other site 869211006503 active site 869211006504 motif 1; other site 869211006505 motif 2; other site 869211006506 motif 3; other site 869211006507 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 869211006508 NeuB family; Region: NeuB; pfam03102 869211006509 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 869211006510 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 869211006511 PAS domain S-box; Region: sensory_box; TIGR00229 869211006512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211006513 Histidine kinase; Region: HisKA_2; pfam07568 869211006514 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 869211006515 ATP binding site [chemical binding]; other site 869211006516 Mg2+ binding site [ion binding]; other site 869211006517 G-X-G motif; other site 869211006518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211006519 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869211006520 active site 869211006521 motif I; other site 869211006522 motif II; other site 869211006523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211006524 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 869211006525 putative FMN binding site [chemical binding]; other site 869211006526 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869211006527 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869211006528 active site 869211006529 metal binding site [ion binding]; metal-binding site 869211006530 Amino acid permease; Region: AA_permease_2; pfam13520 869211006531 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 869211006532 Protein export membrane protein; Region: SecD_SecF; pfam02355 869211006533 protein-export membrane protein SecD; Region: secD; TIGR01129 869211006534 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 869211006535 Preprotein translocase subunit; Region: YajC; pfam02699 869211006536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211006537 MULE transposase domain; Region: MULE; pfam10551 869211006538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211006539 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 869211006540 putative ADP-binding pocket [chemical binding]; other site 869211006541 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 869211006542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211006543 Outer membrane efflux protein; Region: OEP; pfam02321 869211006544 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 869211006545 HlyD family secretion protein; Region: HlyD_3; pfam13437 869211006546 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869211006547 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869211006548 Walker A/P-loop; other site 869211006549 ATP binding site [chemical binding]; other site 869211006550 Q-loop/lid; other site 869211006551 ABC transporter signature motif; other site 869211006552 Walker B; other site 869211006553 D-loop; other site 869211006554 H-loop/switch region; other site 869211006555 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869211006556 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869211006557 Walker A/P-loop; other site 869211006558 ATP binding site [chemical binding]; other site 869211006559 Q-loop/lid; other site 869211006560 ABC transporter signature motif; other site 869211006561 Walker B; other site 869211006562 D-loop; other site 869211006563 H-loop/switch region; other site 869211006564 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869211006565 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 869211006566 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869211006567 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 869211006568 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 869211006569 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869211006570 E3 interaction surface; other site 869211006571 lipoyl attachment site [posttranslational modification]; other site 869211006572 e3 binding domain; Region: E3_binding; pfam02817 869211006573 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869211006574 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869211006575 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869211006576 alpha subunit interface [polypeptide binding]; other site 869211006577 TPP binding site [chemical binding]; other site 869211006578 heterodimer interface [polypeptide binding]; other site 869211006579 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869211006580 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 869211006581 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869211006582 tetramer interface [polypeptide binding]; other site 869211006583 TPP-binding site [chemical binding]; other site 869211006584 heterodimer interface [polypeptide binding]; other site 869211006585 phosphorylation loop region [posttranslational modification] 869211006586 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 869211006587 heat shock protein 90; Provisional; Region: PRK05218 869211006588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211006589 ATP binding site [chemical binding]; other site 869211006590 Mg2+ binding site [ion binding]; other site 869211006591 G-X-G motif; other site 869211006592 SurA N-terminal domain; Region: SurA_N_3; cl07813 869211006593 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 869211006594 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 869211006595 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869211006596 dihydroorotase; Provisional; Region: PRK05451 869211006597 active site 869211006598 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 869211006599 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 869211006600 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 869211006601 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869211006602 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869211006603 Peptidase M16C associated; Region: M16C_assoc; pfam08367 869211006604 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 869211006605 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869211006606 tetramer interface [polypeptide binding]; other site 869211006607 TPP-binding site [chemical binding]; other site 869211006608 heterodimer interface [polypeptide binding]; other site 869211006609 phosphorylation loop region [posttranslational modification] 869211006610 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869211006611 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 869211006612 PYR/PP interface [polypeptide binding]; other site 869211006613 dimer interface [polypeptide binding]; other site 869211006614 TPP binding site [chemical binding]; other site 869211006615 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869211006616 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869211006617 E3 interaction surface; other site 869211006618 lipoyl attachment site [posttranslational modification]; other site 869211006619 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869211006620 dimer interface [polypeptide binding]; other site 869211006621 active site 869211006622 CoA binding pocket [chemical binding]; other site 869211006623 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 869211006624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211006625 FeS/SAM binding site; other site 869211006626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211006627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211006628 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211006629 MULE transposase domain; Region: MULE; pfam10551 869211006630 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 869211006631 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 869211006632 putative catalytic cysteine [active] 869211006633 gamma-glutamyl kinase; Provisional; Region: PRK05429 869211006634 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 869211006635 nucleotide binding site [chemical binding]; other site 869211006636 homotetrameric interface [polypeptide binding]; other site 869211006637 putative phosphate binding site [ion binding]; other site 869211006638 putative allosteric binding site; other site 869211006639 PUA domain; Region: PUA; pfam01472 869211006640 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 869211006641 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 869211006642 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 869211006643 UbiA prenyltransferase family; Region: UbiA; pfam01040 869211006644 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869211006645 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869211006646 substrate binding pocket [chemical binding]; other site 869211006647 chain length determination region; other site 869211006648 substrate-Mg2+ binding site; other site 869211006649 catalytic residues [active] 869211006650 aspartate-rich region 1; other site 869211006651 active site lid residues [active] 869211006652 aspartate-rich region 2; other site 869211006653 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 869211006654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869211006655 Oleosin; Region: Oleosin; pfam01277 869211006656 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 869211006657 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 869211006658 MOFRL family; Region: MOFRL; pfam05161 869211006659 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869211006660 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 869211006661 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 869211006662 putative FMN binding site [chemical binding]; other site 869211006663 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 869211006664 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869211006665 transcription termination factor Rho; Provisional; Region: rho; PRK09376 869211006666 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 869211006667 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 869211006668 RNA binding site [nucleotide binding]; other site 869211006669 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 869211006670 multimer interface [polypeptide binding]; other site 869211006671 Walker A motif; other site 869211006672 ATP binding site [chemical binding]; other site 869211006673 Walker B motif; other site 869211006674 competence damage-inducible protein A; Provisional; Region: PRK00549 869211006675 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869211006676 putative MPT binding site; other site 869211006677 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 869211006678 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 869211006679 Response regulator receiver domain; Region: Response_reg; pfam00072 869211006680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211006681 active site 869211006682 phosphorylation site [posttranslational modification] 869211006683 intermolecular recognition site; other site 869211006684 dimerization interface [polypeptide binding]; other site 869211006685 YARHG domain; Region: YARHG; pfam13308 869211006686 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869211006687 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869211006688 ring oligomerisation interface [polypeptide binding]; other site 869211006689 ATP/Mg binding site [chemical binding]; other site 869211006690 stacking interactions; other site 869211006691 hinge regions; other site 869211006692 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 869211006693 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869211006694 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869211006695 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869211006696 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869211006697 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 869211006698 Arginine repressor [Transcription]; Region: ArgR; COG1438 869211006699 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869211006700 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869211006701 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 869211006702 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869211006703 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 869211006704 nucleotide binding site [chemical binding]; other site 869211006705 N-acetyl-L-glutamate binding site [chemical binding]; other site 869211006706 acetylornithine aminotransferase; Provisional; Region: PRK02627 869211006707 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869211006708 inhibitor-cofactor binding pocket; inhibition site 869211006709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211006710 catalytic residue [active] 869211006711 argininosuccinate synthase; Provisional; Region: PRK13820 869211006712 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 869211006713 ANP binding site [chemical binding]; other site 869211006714 Substrate Binding Site II [chemical binding]; other site 869211006715 Substrate Binding Site I [chemical binding]; other site 869211006716 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 869211006717 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869211006718 active site 869211006719 dimer interface [polypeptide binding]; other site 869211006720 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869211006721 dimer interface [polypeptide binding]; other site 869211006722 active site 869211006723 enolase; Provisional; Region: eno; PRK00077 869211006724 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869211006725 dimer interface [polypeptide binding]; other site 869211006726 metal binding site [ion binding]; metal-binding site 869211006727 substrate binding pocket [chemical binding]; other site 869211006728 Acylphosphatase; Region: Acylphosphatase; pfam00708 869211006729 Response regulator receiver domain; Region: Response_reg; pfam00072 869211006730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211006731 active site 869211006732 phosphorylation site [posttranslational modification] 869211006733 intermolecular recognition site; other site 869211006734 dimerization interface [polypeptide binding]; other site 869211006735 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 869211006736 DNA binding residues [nucleotide binding] 869211006737 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869211006738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211006739 active site 869211006740 phosphorylation site [posttranslational modification] 869211006741 intermolecular recognition site; other site 869211006742 dimerization interface [polypeptide binding]; other site 869211006743 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869211006744 CoenzymeA binding site [chemical binding]; other site 869211006745 subunit interaction site [polypeptide binding]; other site 869211006746 PHB binding site; other site 869211006747 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 869211006748 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 869211006749 ligand binding site [chemical binding]; other site 869211006750 flexible hinge region; other site 869211006751 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 869211006752 non-specific DNA interactions [nucleotide binding]; other site 869211006753 DNA binding site [nucleotide binding] 869211006754 sequence specific DNA binding site [nucleotide binding]; other site 869211006755 putative cAMP binding site [chemical binding]; other site 869211006756 4Fe-4S binding domain; Region: Fer4_6; pfam12837 869211006757 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 869211006758 hybrid cluster protein; Provisional; Region: PRK05290 869211006759 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869211006760 ACS interaction site; other site 869211006761 CODH interaction site; other site 869211006762 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 869211006763 hybrid metal cluster; other site 869211006764 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 869211006765 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 869211006766 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 869211006767 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 869211006768 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211006769 MULE transposase domain; Region: MULE; pfam10551 869211006770 Transposase domain (DUF772); Region: DUF772; pfam05598 869211006771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869211006772 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 869211006773 putative ADP-ribose binding site [chemical binding]; other site 869211006774 putative active site [active] 869211006775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 869211006776 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869211006777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211006778 Walker A/P-loop; other site 869211006779 ATP binding site [chemical binding]; other site 869211006780 Q-loop/lid; other site 869211006781 ABC transporter signature motif; other site 869211006782 Walker B; other site 869211006783 D-loop; other site 869211006784 H-loop/switch region; other site 869211006785 Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; Region: Calpain_III; cl00165 869211006786 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869211006787 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869211006788 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869211006789 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869211006790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 869211006791 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869211006792 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869211006793 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869211006794 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869211006795 putative active site [active] 869211006796 substrate binding site [chemical binding]; other site 869211006797 putative cosubstrate binding site; other site 869211006798 catalytic site [active] 869211006799 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869211006800 substrate binding site [chemical binding]; other site 869211006801 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869211006802 active site 869211006803 catalytic residues [active] 869211006804 metal binding site [ion binding]; metal-binding site 869211006805 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211006806 MULE transposase domain; Region: MULE; pfam10551 869211006807 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869211006808 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 869211006809 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 869211006810 DctM-like transporters; Region: DctM; pfam06808 869211006811 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 869211006812 short chain dehydrogenase; Provisional; Region: PRK06181 869211006813 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 869211006814 putative NAD(P) binding site [chemical binding]; other site 869211006815 homotetramer interface [polypeptide binding]; other site 869211006816 active site 869211006817 homodimer interface [polypeptide binding]; other site 869211006818 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 869211006819 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 869211006820 substrate-cofactor binding pocket; other site 869211006821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211006822 catalytic residue [active] 869211006823 monofunctional chorismate mutase, eukaryotic type; Region: CM_pl-yst; TIGR01802 869211006824 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 869211006825 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 869211006826 nudix motif; other site 869211006827 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 869211006828 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 869211006829 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 869211006830 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869211006831 HflX GTPase family; Region: HflX; cd01878 869211006832 G1 box; other site 869211006833 GTP/Mg2+ binding site [chemical binding]; other site 869211006834 Switch I region; other site 869211006835 G2 box; other site 869211006836 G3 box; other site 869211006837 Switch II region; other site 869211006838 G4 box; other site 869211006839 G5 box; other site 869211006840 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 869211006841 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869211006842 Ligand Binding Site [chemical binding]; other site 869211006843 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869211006844 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 869211006845 intersubunit interface [polypeptide binding]; other site 869211006846 active site 869211006847 Zn2+ binding site [ion binding]; other site 869211006848 L-arabinose isomerase; Provisional; Region: PRK02929 869211006849 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 869211006850 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 869211006851 trimer interface [polypeptide binding]; other site 869211006852 putative substrate binding site [chemical binding]; other site 869211006853 putative metal binding site [ion binding]; other site 869211006854 ribulokinase; Provisional; Region: PRK04123 869211006855 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869211006856 nucleotide binding site [chemical binding]; other site 869211006857 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869211006858 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869211006859 Walker A/P-loop; other site 869211006860 ATP binding site [chemical binding]; other site 869211006861 Q-loop/lid; other site 869211006862 ABC transporter signature motif; other site 869211006863 Walker B; other site 869211006864 D-loop; other site 869211006865 H-loop/switch region; other site 869211006866 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869211006867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869211006868 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869211006869 TM-ABC transporter signature motif; other site 869211006870 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 869211006871 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869211006872 ligand binding site [chemical binding]; other site 869211006873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869211006874 DNA binding site [nucleotide binding] 869211006875 domain linker motif; other site 869211006876 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869211006877 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 869211006878 ligand binding site [chemical binding]; other site 869211006879 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869211006880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006881 dimer interface [polypeptide binding]; other site 869211006882 conserved gate region; other site 869211006883 putative PBP binding loops; other site 869211006884 ABC-ATPase subunit interface; other site 869211006885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869211006886 dimer interface [polypeptide binding]; other site 869211006887 conserved gate region; other site 869211006888 putative PBP binding loops; other site 869211006889 ABC-ATPase subunit interface; other site 869211006890 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869211006891 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869211006892 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 869211006893 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211006894 fumarate hydratase; Reviewed; Region: fumC; PRK00485 869211006895 Class II fumarases; Region: Fumarase_classII; cd01362 869211006896 active site 869211006897 tetramer interface [polypeptide binding]; other site 869211006898 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 869211006899 endoglucanase; Region: PLN02420 869211006900 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 869211006901 Cellulose binding domain; Region: CBM_3; smart01067 869211006902 endoglucanase; Region: PLN02420 869211006903 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 869211006904 Cellulose binding domain; Region: CBM_3; pfam00942 869211006905 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 869211006906 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 869211006907 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869211006908 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869211006909 minor groove reading motif; other site 869211006910 helix-hairpin-helix signature motif; other site 869211006911 substrate binding pocket [chemical binding]; other site 869211006912 active site 869211006913 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 869211006914 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869211006915 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 869211006916 heterodimer interface [polypeptide binding]; other site 869211006917 active site 869211006918 FMN binding site [chemical binding]; other site 869211006919 homodimer interface [polypeptide binding]; other site 869211006920 substrate binding site [chemical binding]; other site 869211006921 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 869211006922 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 869211006923 FAD binding pocket [chemical binding]; other site 869211006924 FAD binding motif [chemical binding]; other site 869211006925 phosphate binding motif [ion binding]; other site 869211006926 beta-alpha-beta structure motif; other site 869211006927 NAD binding pocket [chemical binding]; other site 869211006928 Iron coordination center [ion binding]; other site 869211006929 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 869211006930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 869211006931 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 869211006932 aconitate hydratase; Validated; Region: PRK09277 869211006933 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 869211006934 substrate binding site [chemical binding]; other site 869211006935 ligand binding site [chemical binding]; other site 869211006936 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 869211006937 substrate binding site [chemical binding]; other site 869211006938 Winged helix-turn helix; Region: HTH_29; pfam13551 869211006939 Homeodomain-like domain; Region: HTH_23; pfam13384 869211006940 Homeodomain-like domain; Region: HTH_32; pfam13565 869211006941 Integrase core domain; Region: rve; pfam00665 869211006942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869211006943 Transposase; Region: HTH_Tnp_1; pfam01527 869211006944 putative transposase OrfB; Reviewed; Region: PHA02517 869211006945 HTH-like domain; Region: HTH_21; pfam13276 869211006946 Integrase core domain; Region: rve; pfam00665 869211006947 Integrase core domain; Region: rve_3; pfam13683 869211006948 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869211006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211006950 active site 869211006951 phosphorylation site [posttranslational modification] 869211006952 intermolecular recognition site; other site 869211006953 dimerization interface [polypeptide binding]; other site 869211006954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211006955 Walker A motif; other site 869211006956 ATP binding site [chemical binding]; other site 869211006957 Walker B motif; other site 869211006958 arginine finger; other site 869211006959 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869211006960 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 869211006961 PUA domain; Region: PUA; cl00607 869211006962 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869211006963 putative RNA binding site [nucleotide binding]; other site 869211006964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211006965 S-adenosylmethionine binding site [chemical binding]; other site 869211006966 2-isopropylmalate synthase; Validated; Region: PRK03739 869211006967 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 869211006968 active site 869211006969 catalytic residues [active] 869211006970 metal binding site [ion binding]; metal-binding site 869211006971 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 869211006972 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 869211006973 putative dimer interface [polypeptide binding]; other site 869211006974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 869211006975 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 869211006976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211006977 dimer interface [polypeptide binding]; other site 869211006978 putative CheW interface [polypeptide binding]; other site 869211006979 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 869211006980 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 869211006981 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869211006982 dimer interface [polypeptide binding]; other site 869211006983 ADP-ribose binding site [chemical binding]; other site 869211006984 active site 869211006985 nudix motif; other site 869211006986 metal binding site [ion binding]; metal-binding site 869211006987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 869211006988 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869211006989 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869211006990 active site 869211006991 catalytic tetrad [active] 869211006992 Homeodomain-like domain; Region: HTH_23; pfam13384 869211006993 Winged helix-turn helix; Region: HTH_29; pfam13551 869211006994 Homeodomain-like domain; Region: HTH_32; pfam13565 869211006995 Integrase core domain; Region: rve; pfam00665 869211006996 GTP-binding protein YchF; Reviewed; Region: PRK09601 869211006997 YchF GTPase; Region: YchF; cd01900 869211006998 G1 box; other site 869211006999 GTP/Mg2+ binding site [chemical binding]; other site 869211007000 Switch I region; other site 869211007001 G2 box; other site 869211007002 Switch II region; other site 869211007003 G3 box; other site 869211007004 G4 box; other site 869211007005 G5 box; other site 869211007006 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869211007007 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869211007008 3-isopropylmalate dehydratase, small subunit; Region: leud; TIGR02084 869211007009 substrate binding site [chemical binding]; other site 869211007010 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 869211007011 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 869211007012 substrate binding site [chemical binding]; other site 869211007013 ligand binding site [chemical binding]; other site 869211007014 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 869211007015 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 869211007016 tetramer interface [polypeptide binding]; other site 869211007017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869211007018 catalytic residue [active] 869211007019 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 869211007020 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 869211007021 GSH binding site [chemical binding]; other site 869211007022 catalytic residues [active] 869211007023 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211007024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211007025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211007026 dimer interface [polypeptide binding]; other site 869211007027 putative CheW interface [polypeptide binding]; other site 869211007028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869211007029 DctM-like transporters; Region: DctM; pfam06808 869211007030 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 869211007031 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 869211007032 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869211007033 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 869211007034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211007035 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869211007036 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869211007037 dimer interface [polypeptide binding]; other site 869211007038 putative CheW interface [polypeptide binding]; other site 869211007039 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_3; cd11750 869211007040 Protein of unknown function, DUF608; Region: DUF608; pfam04685 869211007041 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 869211007042 beta-galactosidase; Region: BGL; TIGR03356 869211007043 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869211007044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211007045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869211007046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869211007047 quinolinate synthetase; Provisional; Region: PRK09375 869211007048 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869211007049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211007050 Walker A/P-loop; other site 869211007051 ATP binding site [chemical binding]; other site 869211007052 Q-loop/lid; other site 869211007053 ABC transporter signature motif; other site 869211007054 Walker B; other site 869211007055 D-loop; other site 869211007056 H-loop/switch region; other site 869211007057 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869211007058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869211007059 ABC-ATPase subunit interface; other site 869211007060 dimer interface [polypeptide binding]; other site 869211007061 putative PBP binding regions; other site 869211007062 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 869211007063 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 869211007064 putative binding site residues; other site 869211007065 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 869211007066 putative active site [active] 869211007067 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 869211007068 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869211007069 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869211007070 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869211007071 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869211007072 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869211007073 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 869211007074 B12 binding site [chemical binding]; other site 869211007075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211007076 Radical SAM superfamily; Region: Radical_SAM; pfam04055 869211007077 FeS/SAM binding site; other site 869211007078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211007079 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 869211007080 G-X-G motif; other site 869211007081 RecX family; Region: RecX; pfam02631 869211007082 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869211007083 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869211007084 23S rRNA interface [nucleotide binding]; other site 869211007085 L3 interface [polypeptide binding]; other site 869211007086 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 869211007087 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 869211007088 glutamate-1-semialdehyde-2,1-aminomutase; Region: hemL; TIGR00713 869211007089 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 869211007090 Part of AAA domain; Region: AAA_19; pfam13245 869211007091 Family description; Region: UvrD_C_2; pfam13538 869211007092 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 869211007093 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 869211007094 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869211007095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869211007096 FeS/SAM binding site; other site 869211007097 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 869211007098 Helix-turn-helix domain; Region: HTH_25; pfam13413 869211007099 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 869211007100 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 869211007101 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 869211007102 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 869211007103 nucleotide binding site [chemical binding]; other site 869211007104 substrate binding site [chemical binding]; other site 869211007105 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 869211007106 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 869211007107 Uncharacterized conserved protein [Function unknown]; Region: COG1656 869211007108 Protein of unknown function DUF82; Region: DUF82; pfam01927 869211007109 TPR repeat; Region: TPR_11; pfam13414 869211007110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211007111 binding surface 869211007112 TPR motif; other site 869211007113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211007114 binding surface 869211007115 TPR motif; other site 869211007116 TPR repeat; Region: TPR_11; pfam13414 869211007117 amino acid transporter; Region: 2A0306; TIGR00909 869211007118 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869211007119 active site 869211007120 phosphorylation site [posttranslational modification] 869211007121 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 869211007122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211007123 motif II; other site 869211007124 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869211007125 trimer interface [polypeptide binding]; other site 869211007126 active site 869211007127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869211007128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869211007129 metal binding site [ion binding]; metal-binding site 869211007130 active site 869211007131 I-site; other site 869211007132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869211007133 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869211007134 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869211007135 active site 869211007136 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211007137 MULE transposase domain; Region: MULE; pfam10551 869211007138 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 869211007139 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869211007140 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869211007141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869211007142 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869211007143 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 869211007144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 869211007145 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 869211007146 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 869211007147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211007148 dimer interface [polypeptide binding]; other site 869211007149 phosphorylation site [posttranslational modification] 869211007150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211007151 ATP binding site [chemical binding]; other site 869211007152 Mg2+ binding site [ion binding]; other site 869211007153 G-X-G motif; other site 869211007154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869211007155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211007156 active site 869211007157 phosphorylation site [posttranslational modification] 869211007158 intermolecular recognition site; other site 869211007159 dimerization interface [polypeptide binding]; other site 869211007160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869211007161 DNA binding site [nucleotide binding] 869211007162 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 869211007163 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869211007164 dimer interface [polypeptide binding]; other site 869211007165 active site 869211007166 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869211007167 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869211007168 NAD(P) binding site [chemical binding]; other site 869211007169 homotetramer interface [polypeptide binding]; other site 869211007170 homodimer interface [polypeptide binding]; other site 869211007171 active site 869211007172 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869211007173 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869211007174 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 869211007175 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 869211007176 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 869211007177 active site 869211007178 catalytic residues [active] 869211007179 metal binding site [ion binding]; metal-binding site 869211007180 homodimer binding site [polypeptide binding]; other site 869211007181 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 869211007182 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869211007183 carboxyltransferase (CT) interaction site; other site 869211007184 biotinylation site [posttranslational modification]; other site 869211007185 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 869211007186 PilZ domain; Region: PilZ; pfam07238 869211007187 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 869211007188 active site 869211007189 metal-binding site [ion binding] 869211007190 nucleotide-binding site [chemical binding]; other site 869211007191 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869211007192 FAD binding site [chemical binding]; other site 869211007193 DnaJ domain; Region: DnaJ; pfam00226 869211007194 HSP70 interaction site [polypeptide binding]; other site 869211007195 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 869211007196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869211007197 putative substrate translocation pore; other site 869211007198 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211007199 MULE transposase domain; Region: MULE; pfam10551 869211007200 Homeodomain-like domain; Region: HTH_23; pfam13384 869211007201 Winged helix-turn helix; Region: HTH_29; pfam13551 869211007202 Homeodomain-like domain; Region: HTH_32; pfam13565 869211007203 Integrase core domain; Region: rve; pfam00665 869211007204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 869211007205 MULE transposase domain; Region: MULE; pfam10551 869211007206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211007207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211007208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869211007209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869211007210 Outer membrane efflux protein; Region: OEP; pfam02321 869211007211 Outer membrane efflux protein; Region: OEP; pfam02321 869211007212 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 869211007213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869211007214 carboxyltransferase (CT) interaction site; other site 869211007215 biotinylation site [posttranslational modification]; other site 869211007216 HlyD family secretion protein; Region: HlyD_3; pfam13437 869211007217 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 869211007218 Protein export membrane protein; Region: SecD_SecF; cl14618 869211007219 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869211007220 Peptidase family U32; Region: Peptidase_U32; pfam01136 869211007221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869211007222 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 869211007223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869211007224 S-adenosylmethionine binding site [chemical binding]; other site 869211007225 Rhomboid family; Region: Rhomboid; pfam01694 869211007226 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 869211007227 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869211007228 dimer interface [polypeptide binding]; other site 869211007229 motif 1; other site 869211007230 active site 869211007231 motif 2; other site 869211007232 motif 3; other site 869211007233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 869211007234 tRNA synthetase B5 domain; Region: B5; smart00874 869211007235 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869211007236 dimer interface [polypeptide binding]; other site 869211007237 motif 1; other site 869211007238 motif 3; other site 869211007239 motif 2; other site 869211007240 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 869211007241 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869211007242 P-loop; other site 869211007243 Magnesium ion binding site [ion binding]; other site 869211007244 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869211007245 Magnesium ion binding site [ion binding]; other site 869211007246 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 869211007247 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 869211007248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869211007249 motif II; other site 869211007250 CHAP domain; Region: CHAP; cl17642 869211007251 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 869211007252 ApbE family; Region: ApbE; pfam02424 869211007253 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 869211007254 P-loop containing region of AAA domain; Region: AAA_29; cl17516 869211007255 AAA domain; Region: AAA_23; pfam13476 869211007256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869211007257 Q-loop/lid; other site 869211007258 ABC transporter signature motif; other site 869211007259 Walker B; other site 869211007260 D-loop; other site 869211007261 H-loop/switch region; other site 869211007262 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869211007263 active site 869211007264 metal binding site [ion binding]; metal-binding site 869211007265 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 869211007266 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869211007267 Ferritin-like domain; Region: Ferritin; pfam00210 869211007268 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 869211007269 diiron binding motif [ion binding]; other site 869211007270 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 869211007271 putative active site [active] 869211007272 metal binding site [ion binding]; metal-binding site 869211007273 homodimer binding site [polypeptide binding]; other site 869211007274 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 869211007275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211007276 active site 869211007277 phosphorylation site [posttranslational modification] 869211007278 intermolecular recognition site; other site 869211007279 dimerization interface [polypeptide binding]; other site 869211007280 CheB methylesterase; Region: CheB_methylest; pfam01339 869211007281 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 869211007282 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 869211007283 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 869211007284 CTP synthetase; Validated; Region: pyrG; PRK05380 869211007285 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869211007286 Catalytic site [active] 869211007287 active site 869211007288 UTP binding site [chemical binding]; other site 869211007289 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869211007290 active site 869211007291 putative oxyanion hole; other site 869211007292 catalytic triad [active] 869211007293 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 869211007294 OstA-like protein; Region: OstA; cl00844 869211007295 OstA-like protein; Region: OstA; cl00844 869211007296 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 869211007297 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 869211007298 Walker A/P-loop; other site 869211007299 ATP binding site [chemical binding]; other site 869211007300 Q-loop/lid; other site 869211007301 ABC transporter signature motif; other site 869211007302 Walker B; other site 869211007303 D-loop; other site 869211007304 H-loop/switch region; other site 869211007305 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 869211007306 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 869211007307 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 869211007308 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 869211007309 Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482 869211007310 30S subunit binding site; other site 869211007311 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 869211007312 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 869211007313 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 869211007314 Hpr binding site; other site 869211007315 active site 869211007316 homohexamer subunit interaction site [polypeptide binding]; other site 869211007317 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869211007318 dimerization domain swap beta strand [polypeptide binding]; other site 869211007319 regulatory protein interface [polypeptide binding]; other site 869211007320 active site 869211007321 regulatory phosphorylation site [posttranslational modification]; other site 869211007322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869211007323 dimerization interface [polypeptide binding]; other site 869211007324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 869211007325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869211007326 dimer interface [polypeptide binding]; other site 869211007327 phosphorylation site [posttranslational modification] 869211007328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211007329 ATP binding site [chemical binding]; other site 869211007330 Mg2+ binding site [ion binding]; other site 869211007331 G-X-G motif; other site 869211007332 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869211007333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869211007334 active site 869211007335 phosphorylation site [posttranslational modification] 869211007336 intermolecular recognition site; other site 869211007337 dimerization interface [polypeptide binding]; other site 869211007338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211007339 Walker A motif; other site 869211007340 ATP binding site [chemical binding]; other site 869211007341 Walker B motif; other site 869211007342 arginine finger; other site 869211007343 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869211007344 LexA repressor; Validated; Region: PRK00215 869211007345 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 869211007346 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869211007347 Catalytic site [active] 869211007348 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869211007349 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869211007350 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869211007351 GIY-YIG motif/motif A; other site 869211007352 active site 869211007353 catalytic site [active] 869211007354 putative DNA binding site [nucleotide binding]; other site 869211007355 metal binding site [ion binding]; metal-binding site 869211007356 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869211007357 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 869211007358 DNA binding site [nucleotide binding] 869211007359 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 869211007360 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 869211007361 Interdomain contacts; other site 869211007362 Cytokine receptor motif; other site 869211007363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211007364 binding surface 869211007365 TPR motif; other site 869211007366 TPR repeat; Region: TPR_11; pfam13414 869211007367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211007368 binding surface 869211007369 TPR repeat; Region: TPR_11; pfam13414 869211007370 TPR motif; other site 869211007371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211007372 binding surface 869211007373 TPR repeat; Region: TPR_11; pfam13414 869211007374 TPR motif; other site 869211007375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869211007376 binding surface 869211007377 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869211007378 TPR motif; other site 869211007379 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869211007380 catalytic core [active] 869211007381 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 869211007382 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 869211007383 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 869211007384 putative active site [active] 869211007385 putative metal binding site [ion binding]; other site 869211007386 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869211007387 Peptidase family M23; Region: Peptidase_M23; pfam01551 869211007388 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 869211007389 putative efflux protein, MATE family; Region: matE; TIGR00797 869211007390 polyphosphate kinase; Provisional; Region: PRK05443 869211007391 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 869211007392 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 869211007393 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 869211007394 putative domain interface [polypeptide binding]; other site 869211007395 putative active site [active] 869211007396 catalytic site [active] 869211007397 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 869211007398 putative domain interface [polypeptide binding]; other site 869211007399 putative active site [active] 869211007400 catalytic site [active] 869211007401 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 869211007402 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 869211007403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869211007404 Zn2+ binding site [ion binding]; other site 869211007405 Mg2+ binding site [ion binding]; other site 869211007406 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 869211007407 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869211007408 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 869211007409 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 869211007410 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869211007411 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 869211007412 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 869211007413 Dimer interface [polypeptide binding]; other site 869211007414 anticodon binding site; other site 869211007415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869211007416 motif 1; other site 869211007417 dimer interface [polypeptide binding]; other site 869211007418 active site 869211007419 motif 2; other site 869211007420 motif 3; other site 869211007421 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869211007422 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869211007423 GatB domain; Region: GatB_Yqey; smart00845 869211007424 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 869211007425 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 869211007426 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686 869211007427 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 869211007428 Trehalase; Region: Trehalase; cl17346 869211007429 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869211007430 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 869211007431 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869211007432 FecR protein; Region: FecR; pfam04773 869211007433 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 869211007434 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869211007435 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 869211007436 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 869211007437 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 869211007438 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 869211007439 anti sigma factor interaction site; other site 869211007440 regulatory phosphorylation site [posttranslational modification]; other site 869211007441 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 869211007442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 869211007443 Mg2+ binding site [ion binding]; other site 869211007444 G-X-G motif; other site 869211007445 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869211007446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869211007447 NAD(P) binding site [chemical binding]; other site 869211007448 active site 869211007449 recombination protein RecR; Reviewed; Region: recR; PRK00076 869211007450 RecR protein; Region: RecR; pfam02132 869211007451 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869211007452 putative active site [active] 869211007453 putative metal-binding site [ion binding]; other site 869211007454 tetramer interface [polypeptide binding]; other site 869211007455 hypothetical protein; Validated; Region: PRK00153 869211007456 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 869211007457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869211007458 Walker A motif; other site 869211007459 ATP binding site [chemical binding]; other site 869211007460 Walker B motif; other site 869211007461 arginine finger; other site 869211007462 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 869211007463 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869211007464 active site 869211007465 phosphorylation site [posttranslational modification] 869211007466 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 869211007467 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 869211007468 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211007469 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211007470 FtsX-like permease family; Region: FtsX; pfam02687 869211007471 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869211007472 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869211007473 FtsX-like permease family; Region: FtsX; pfam02687 869211007474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869211007475 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869211007476 Walker A/P-loop; other site 869211007477 ATP binding site [chemical binding]; other site 869211007478 Q-loop/lid; other site 869211007479 ABC transporter signature motif; other site 869211007480 Walker B; other site 869211007481 D-loop; other site 869211007482 H-loop/switch region; other site 869211007483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869211007484 putative DNA binding site [nucleotide binding]; other site 869211007485 putative Zn2+ binding site [ion binding]; other site 869211007486 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 869211007487 ParB-like nuclease domain; Region: ParBc; pfam02195 869211007488 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 869211007489 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 869211007490 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869211007491 P-loop; other site 869211007492 Magnesium ion binding site [ion binding]; other site 869211007493 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869211007494 Magnesium ion binding site [ion binding]; other site 869211007495 NifU-like domain; Region: NifU; pfam01106 869211007496 adenosine deaminase; Provisional; Region: PRK09358 869211007497 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 869211007498 active site 869211007499 DNA gyrase subunit A; Validated; Region: PRK05560 869211007500 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869211007501 CAP-like domain; other site 869211007502 active site 869211007503 primary dimer interface [polypeptide binding]; other site 869211007504 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869211007505 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869211007506 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869211007507 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869211007508 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869211007509 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869211007510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869211007511 Mg2+ binding site [ion binding]; other site 869211007512 G-X-G motif; other site 869211007513 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869211007514 anchoring element; other site 869211007515 dimer interface [polypeptide binding]; other site 869211007516 ATP binding site [chemical binding]; other site 869211007517 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869211007518 active site 869211007519 putative metal-binding site [ion binding]; other site 869211007520 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986