-- dump date   	20140620_072816
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
504472000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
504472000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
504472000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472000004	Walker A motif; other site
504472000005	ATP binding site [chemical binding]; other site
504472000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
504472000007	Walker B motif; other site
504472000008	arginine finger; other site
504472000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
504472000010	DnaA box-binding interface [nucleotide binding]; other site
504472000011	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
504472000012	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
504472000013	Immunoglobulin domain; Region: Ig; cl11960
504472000014	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472000015	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472000016	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472000017	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
504472000018	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
504472000019	Isochorismatase family; Region: Isochorismatase; pfam00857
504472000020	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
504472000021	catalytic triad [active]
504472000022	conserved cis-peptide bond; other site
504472000023	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472000024	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472000025	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472000026	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
504472000027	active site
504472000028	Amidohydrolase; Region: Amidohydro_2; pfam04909
504472000029	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
504472000030	homotrimer interaction site [polypeptide binding]; other site
504472000031	zinc binding site [ion binding]; other site
504472000032	CDP-binding sites; other site
504472000033	HEPN domain; Region: HEPN; cl00824
504472000034	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
504472000035	active site
504472000036	NTP binding site [chemical binding]; other site
504472000037	metal binding triad [ion binding]; metal-binding site
504472000038	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472000039	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472000040	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472000041	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472000042	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000043	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472000044	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472000045	SusD family; Region: SusD; pfam07980
504472000046	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
504472000047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472000048	Walker A motif; other site
504472000049	ATP binding site [chemical binding]; other site
504472000050	Walker B motif; other site
504472000051	arginine finger; other site
504472000052	Ion transport protein; Region: Ion_trans; pfam00520
504472000053	Ion channel; Region: Ion_trans_2; pfam07885
504472000054	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472000055	muropeptide transporter; Validated; Region: ampG; cl17669
504472000056	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472000057	Coenzyme A binding pocket [chemical binding]; other site
504472000058	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472000059	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
504472000060	substrate binding pocket [chemical binding]; other site
504472000061	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
504472000062	active site
504472000063	catalytic triad [active]
504472000064	oxyanion hole [active]
504472000065	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
504472000066	DNA photolyase; Region: DNA_photolyase; pfam00875
504472000067	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000068	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000069	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472000070	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472000071	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
504472000072	N-acetyl-D-glucosamine binding site [chemical binding]; other site
504472000073	catalytic residue [active]
504472000074	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
504472000075	N-acetyl-D-glucosamine binding site [chemical binding]; other site
504472000076	catalytic residue [active]
504472000077	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
504472000078	N-acetyl-D-glucosamine binding site [chemical binding]; other site
504472000079	catalytic residue [active]
504472000080	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
504472000081	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472000082	ATP binding site [chemical binding]; other site
504472000083	putative Mg++ binding site [ion binding]; other site
504472000084	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472000085	nucleotide binding region [chemical binding]; other site
504472000086	ATP-binding site [chemical binding]; other site
504472000087	RQC domain; Region: RQC; pfam09382
504472000088	HRDC domain; Region: HRDC; pfam00570
504472000089	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
504472000090	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472000091	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
504472000092	active site
504472000093	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
504472000094	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
504472000095	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472000096	active site
504472000097	HIGH motif; other site
504472000098	nucleotide binding site [chemical binding]; other site
504472000099	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
504472000100	KMSK motif region; other site
504472000101	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
504472000102	tRNA binding surface [nucleotide binding]; other site
504472000103	anticodon binding site; other site
504472000104	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
504472000105	catalytic residues [active]
504472000106	dimer interface [polypeptide binding]; other site
504472000107	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
504472000108	UbiA prenyltransferase family; Region: UbiA; pfam01040
504472000109	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472000110	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472000111	active site
504472000112	metal binding site [ion binding]; metal-binding site
504472000113	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472000114	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
504472000115	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472000116	active site
504472000117	HIGH motif; other site
504472000118	nucleotide binding site [chemical binding]; other site
504472000119	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472000120	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472000121	active site
504472000122	KMSKS motif; other site
504472000123	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
504472000124	tRNA binding surface [nucleotide binding]; other site
504472000125	anticodon binding site; other site
504472000126	putative transposase; Provisional; Region: PRK09857
504472000127	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
504472000128	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472000129	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472000130	ligand binding site [chemical binding]; other site
504472000131	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472000132	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472000133	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472000134	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472000135	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472000136	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472000137	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
504472000138	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
504472000139	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
504472000140	Uncharacterized conserved protein [Function unknown]; Region: COG1479
504472000141	Protein of unknown function DUF262; Region: DUF262; pfam03235
504472000142	Protein of unknown function DUF262; Region: DUF262; pfam03235
504472000143	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
504472000144	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
504472000145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000146	active site
504472000147	phosphorylation site [posttranslational modification]
504472000148	intermolecular recognition site; other site
504472000149	dimerization interface [polypeptide binding]; other site
504472000150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472000151	Walker B motif; other site
504472000152	arginine finger; other site
504472000153	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
504472000154	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
504472000155	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472000156	catalytic residue [active]
504472000157	K+ potassium transporter; Region: K_trans; pfam02705
504472000158	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
504472000159	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
504472000160	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472000161	Soluble P-type ATPase [General function prediction only]; Region: COG4087
504472000162	K+-transporting ATPase, c chain; Region: KdpC; cl00944
504472000163	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
504472000164	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
504472000165	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
504472000166	Ligand Binding Site [chemical binding]; other site
504472000167	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
504472000168	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472000169	dimerization interface [polypeptide binding]; other site
504472000170	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472000171	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000172	putative active site [active]
504472000173	heme pocket [chemical binding]; other site
504472000174	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
504472000175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000176	ATP binding site [chemical binding]; other site
504472000177	Mg2+ binding site [ion binding]; other site
504472000178	G-X-G motif; other site
504472000179	Trehalose utilisation; Region: ThuA; pfam06283
504472000180	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
504472000181	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
504472000182	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
504472000183	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
504472000184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472000185	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472000186	DNA binding residues [nucleotide binding]
504472000187	NmrA-like family; Region: NmrA; pfam05368
504472000188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472000189	NAD(P) binding site [chemical binding]; other site
504472000190	active site
504472000191	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472000192	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472000193	dimerization interface [polypeptide binding]; other site
504472000194	putative DNA binding site [nucleotide binding]; other site
504472000195	putative Zn2+ binding site [ion binding]; other site
504472000196	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
504472000197	Strictosidine synthase; Region: Str_synth; pfam03088
504472000198	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
504472000199	Protein of unknown function DUF72; Region: DUF72; pfam01904
504472000200	Low affinity iron permease; Region: Iron_permease; pfam04120
504472000201	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
504472000202	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
504472000203	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
504472000204	active site
504472000205	metal binding site [ion binding]; metal-binding site
504472000206	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
504472000207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472000208	NAD(P) binding site [chemical binding]; other site
504472000209	active site
504472000210	short chain dehydrogenase; Provisional; Region: PRK06180
504472000211	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472000212	NADP binding site [chemical binding]; other site
504472000213	active site
504472000214	steroid binding site; other site
504472000215	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
504472000216	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472000217	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
504472000218	active site 2 [active]
504472000219	active site 1 [active]
504472000220	DinB family; Region: DinB; cl17821
504472000221	DinB superfamily; Region: DinB_2; pfam12867
504472000222	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472000223	MarR family; Region: MarR_2; pfam12802
504472000224	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
504472000225	Sodium Bile acid symporter family; Region: SBF; pfam01758
504472000226	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472000227	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472000228	exopolyphosphatase; Region: exo_poly_only; TIGR03706
504472000229	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
504472000230	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
504472000231	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
504472000232	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472000233	active site
504472000234	DNA binding site [nucleotide binding]
504472000235	Int/Topo IB signature motif; other site
504472000236	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
504472000237	GAF domain; Region: GAF; pfam01590
504472000238	Phytochrome region; Region: PHY; pfam00360
504472000239	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000240	dimer interface [polypeptide binding]; other site
504472000241	phosphorylation site [posttranslational modification]
504472000242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000243	ATP binding site [chemical binding]; other site
504472000244	Mg2+ binding site [ion binding]; other site
504472000245	G-X-G motif; other site
504472000246	Response regulator receiver domain; Region: Response_reg; pfam00072
504472000247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000248	active site
504472000249	phosphorylation site [posttranslational modification]
504472000250	intermolecular recognition site; other site
504472000251	dimerization interface [polypeptide binding]; other site
504472000252	PAS fold; Region: PAS_4; pfam08448
504472000253	PAS domain; Region: PAS_9; pfam13426
504472000254	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000255	putative active site [active]
504472000256	heme pocket [chemical binding]; other site
504472000257	PAS fold; Region: PAS_4; pfam08448
504472000258	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
504472000259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000260	dimer interface [polypeptide binding]; other site
504472000261	phosphorylation site [posttranslational modification]
504472000262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000263	ATP binding site [chemical binding]; other site
504472000264	Mg2+ binding site [ion binding]; other site
504472000265	G-X-G motif; other site
504472000266	photoactive yellow protein; Region: photo_yellow; TIGR02373
504472000267	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
504472000268	4-coumarate--CoA ligase, photoactive yellow protein activation family; Region: 4_coum_CoA_lig; TIGR02372
504472000269	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
504472000270	active site
504472000271	AMP binding site [chemical binding]; other site
504472000272	acyl-activating enzyme (AAE) consensus motif; other site
504472000273	CoA binding site [chemical binding]; other site
504472000274	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472000275	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472000276	DNA binding residues [nucleotide binding]
504472000277	FecR protein; Region: FecR; pfam04773
504472000278	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472000279	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472000280	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000281	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472000282	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472000283	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472000284	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472000285	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
504472000286	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
504472000287	putative metal binding site [ion binding]; other site
504472000288	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
504472000289	Cupin domain; Region: Cupin_2; pfam07883
504472000290	Cupin domain; Region: Cupin_2; cl17218
504472000291	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472000292	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472000293	active site
504472000294	catalytic tetrad [active]
504472000295	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
504472000296	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472000297	catalytic loop [active]
504472000298	iron binding site [ion binding]; other site
504472000299	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472000300	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
504472000301	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
504472000302	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472000303	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472000304	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472000305	Fasciclin domain; Region: Fasciclin; pfam02469
504472000306	Fasciclin domain; Region: Fasciclin; cl02663
504472000307	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472000308	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472000309	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000310	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000311	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472000312	GH3 auxin-responsive promoter; Region: GH3; pfam03321
504472000313	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
504472000314	Integrase core domain; Region: rve; pfam00665
504472000315	Integrase core domain; Region: rve_3; pfam13683
504472000316	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
504472000317	HTH-like domain; Region: HTH_21; pfam13276
504472000318	Integrase core domain; Region: rve; pfam00665
504472000319	Integrase core domain; Region: rve_3; pfam13683
504472000320	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472000321	DNA-binding interface [nucleotide binding]; DNA binding site
504472000322	Winged helix-turn helix; Region: HTH_29; pfam13551
504472000323	Uncharacterized conserved protein [Function unknown]; Region: COG5476
504472000324	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
504472000325	MlrC C-terminus; Region: MlrC_C; pfam07171
504472000326	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
504472000327	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
504472000328	[4Fe-4S] binding site [ion binding]; other site
504472000329	molybdopterin cofactor binding site; other site
504472000330	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
504472000331	molybdopterin cofactor binding site; other site
504472000332	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
504472000333	gating phenylalanine in ion channel; other site
504472000334	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
504472000335	zinc binding site [ion binding]; other site
504472000336	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472000337	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
504472000338	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472000339	motif II; other site
504472000340	Kelch domain; Region: Kelch; smart00612
504472000341	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
504472000342	Kelch motif; Region: Kelch_1; pfam01344
504472000343	Kelch motif; Region: Kelch_1; pfam01344
504472000344	Kelch motif; Region: Kelch_6; pfam13964
504472000345	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
504472000346	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472000347	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
504472000348	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
504472000349	PAS domain; Region: PAS_9; pfam13426
504472000350	PAS domain S-box; Region: sensory_box; TIGR00229
504472000351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000352	putative active site [active]
504472000353	heme pocket [chemical binding]; other site
504472000354	PAS fold; Region: PAS_3; pfam08447
504472000355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000356	putative active site [active]
504472000357	heme pocket [chemical binding]; other site
504472000358	PAS domain S-box; Region: sensory_box; TIGR00229
504472000359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000360	putative active site [active]
504472000361	heme pocket [chemical binding]; other site
504472000362	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000363	PAS fold; Region: PAS_3; pfam08447
504472000364	putative active site [active]
504472000365	heme pocket [chemical binding]; other site
504472000366	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472000367	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000368	dimer interface [polypeptide binding]; other site
504472000369	phosphorylation site [posttranslational modification]
504472000370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000371	ATP binding site [chemical binding]; other site
504472000372	Mg2+ binding site [ion binding]; other site
504472000373	G-X-G motif; other site
504472000374	FIST N domain; Region: FIST; pfam08495
504472000375	FIST C domain; Region: FIST_C; pfam10442
504472000376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000377	dimer interface [polypeptide binding]; other site
504472000378	phosphorylation site [posttranslational modification]
504472000379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000380	ATP binding site [chemical binding]; other site
504472000381	Mg2+ binding site [ion binding]; other site
504472000382	G-X-G motif; other site
504472000383	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472000384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000385	active site
504472000386	phosphorylation site [posttranslational modification]
504472000387	intermolecular recognition site; other site
504472000388	dimerization interface [polypeptide binding]; other site
504472000389	Response regulator receiver domain; Region: Response_reg; pfam00072
504472000390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000391	active site
504472000392	phosphorylation site [posttranslational modification]
504472000393	intermolecular recognition site; other site
504472000394	dimerization interface [polypeptide binding]; other site
504472000395	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472000396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000397	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472000398	putative active site [active]
504472000399	heme pocket [chemical binding]; other site
504472000400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000401	putative active site [active]
504472000402	heme pocket [chemical binding]; other site
504472000403	PAS fold; Region: PAS_3; pfam08447
504472000404	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472000405	PAS domain S-box; Region: sensory_box; TIGR00229
504472000406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000407	putative active site [active]
504472000408	heme pocket [chemical binding]; other site
504472000409	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472000410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472000411	putative active site [active]
504472000412	heme pocket [chemical binding]; other site
504472000413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000414	dimer interface [polypeptide binding]; other site
504472000415	phosphorylation site [posttranslational modification]
504472000416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000417	ATP binding site [chemical binding]; other site
504472000418	Mg2+ binding site [ion binding]; other site
504472000419	G-X-G motif; other site
504472000420	OpgC protein; Region: OpgC_C; cl17858
504472000421	Acyltransferase family; Region: Acyl_transf_3; pfam01757
504472000422	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
504472000423	active site
504472000424	catalytic residues [active]
504472000425	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
504472000426	hydroxyglutarate oxidase; Provisional; Region: PRK11728
504472000427	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000428	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000429	Ureide permease; Region: Ureide_permease; pfam07168
504472000430	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472000431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000432	active site
504472000433	phosphorylation site [posttranslational modification]
504472000434	intermolecular recognition site; other site
504472000435	dimerization interface [polypeptide binding]; other site
504472000436	GAF domain; Region: GAF; cl17456
504472000437	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472000438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000439	ATP binding site [chemical binding]; other site
504472000440	Mg2+ binding site [ion binding]; other site
504472000441	G-X-G motif; other site
504472000442	Response regulator receiver domain; Region: Response_reg; pfam00072
504472000443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000444	active site
504472000445	phosphorylation site [posttranslational modification]
504472000446	intermolecular recognition site; other site
504472000447	dimerization interface [polypeptide binding]; other site
504472000448	PAS domain S-box; Region: sensory_box; TIGR00229
504472000449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000450	dimer interface [polypeptide binding]; other site
504472000451	phosphorylation site [posttranslational modification]
504472000452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000453	ATP binding site [chemical binding]; other site
504472000454	Mg2+ binding site [ion binding]; other site
504472000455	G-X-G motif; other site
504472000456	OmpW family; Region: OmpW; cl17427
504472000457	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
504472000458	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
504472000459	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
504472000460	active site
504472000461	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
504472000462	UbiA prenyltransferase family; Region: UbiA; pfam01040
504472000463	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
504472000464	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
504472000465	Fe-S metabolism associated domain; Region: SufE; cl00951
504472000466	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
504472000467	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
504472000468	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
504472000469	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472000470	catalytic residue [active]
504472000471	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000472	Homeodomain-like domain; Region: HTH_23; pfam13384
504472000473	Winged helix-turn helix; Region: HTH_29; pfam13551
504472000474	Homeodomain-like domain; Region: HTH_32; pfam13565
504472000475	Winged helix-turn helix; Region: HTH_33; pfam13592
504472000476	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472000477	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472000478	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
504472000479	FeS assembly protein SufD; Region: sufD; TIGR01981
504472000480	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
504472000481	FeS assembly ATPase SufC; Region: sufC; TIGR01978
504472000482	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
504472000483	Walker A/P-loop; other site
504472000484	ATP binding site [chemical binding]; other site
504472000485	Q-loop/lid; other site
504472000486	ABC transporter signature motif; other site
504472000487	Walker B; other site
504472000488	D-loop; other site
504472000489	H-loop/switch region; other site
504472000490	REJ domain; Region: REJ; pfam02010
504472000491	Cna protein B-type domain; Region: Cna_B; pfam05738
504472000492	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472000493	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472000494	Cna protein B-type domain; Region: Cna_B; pfam05738
504472000495	Cna protein B-type domain; Region: Cna_B; pfam05738
504472000496	Cna protein B-type domain; Region: Cna_B; pfam05738
504472000497	conserved repeat domain; Region: B_ant_repeat; TIGR01451
504472000498	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
504472000499	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472000500	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472000501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472000502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000503	dimer interface [polypeptide binding]; other site
504472000504	phosphorylation site [posttranslational modification]
504472000505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472000506	ATP binding site [chemical binding]; other site
504472000507	Mg2+ binding site [ion binding]; other site
504472000508	G-X-G motif; other site
504472000509	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472000510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000511	active site
504472000512	phosphorylation site [posttranslational modification]
504472000513	intermolecular recognition site; other site
504472000514	dimerization interface [polypeptide binding]; other site
504472000515	LytTr DNA-binding domain; Region: LytTR; smart00850
504472000516	Amidinotransferase; Region: Amidinotransf; cl12043
504472000517	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
504472000518	Amidinotransferase; Region: Amidinotransf; pfam02274
504472000519	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472000520	putative Zn2+ binding site [ion binding]; other site
504472000521	putative DNA binding site [nucleotide binding]; other site
504472000522	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472000523	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472000524	NAD(P) binding site [chemical binding]; other site
504472000525	active site
504472000526	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
504472000527	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
504472000528	putative NAD(P) binding site [chemical binding]; other site
504472000529	active site
504472000530	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472000531	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
504472000532	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
504472000533	NADP binding site [chemical binding]; other site
504472000534	substrate binding site [chemical binding]; other site
504472000535	active site
504472000536	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
504472000537	Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483
504472000538	active site
504472000539	catalytic triad [active]
504472000540	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472000541	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472000542	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472000543	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000544	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472000545	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000546	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472000547	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472000548	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472000549	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000550	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472000551	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000552	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
504472000553	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
504472000554	metal binding site [ion binding]; metal-binding site
504472000555	putative dimer interface [polypeptide binding]; other site
504472000556	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
504472000557	short chain dehydrogenase; Provisional; Region: PRK06181
504472000558	NADP binding site [chemical binding]; other site
504472000559	homodimer interface [polypeptide binding]; other site
504472000560	substrate binding site [chemical binding]; other site
504472000561	active site
504472000562	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
504472000563	dimer interface [polypeptide binding]; other site
504472000564	catalytic triad [active]
504472000565	Inward rectifier potassium channel; Region: IRK; pfam01007
504472000566	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
504472000567	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
504472000568	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
504472000569	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
504472000570	Ligand binding site; other site
504472000571	Putative Catalytic site; other site
504472000572	DXD motif; other site
504472000573	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
504472000574	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
504472000575	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472000576	S-adenosylmethionine binding site [chemical binding]; other site
504472000577	Protein of unknown function (DUF721); Region: DUF721; pfam05258
504472000578	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
504472000579	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
504472000580	homodimer interface [polypeptide binding]; other site
504472000581	substrate-cofactor binding pocket; other site
504472000582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472000583	catalytic residue [active]
504472000584	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
504472000585	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
504472000586	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502
504472000587	active site
504472000588	catalytic triad [active]
504472000589	oxyanion hole [active]
504472000590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
504472000591	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
504472000592	active site flap/lid [active]
504472000593	nucleophilic elbow; other site
504472000594	catalytic triad [active]
504472000595	META domain; Region: META; pfam03724
504472000596	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
504472000597	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
504472000598	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
504472000599	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
504472000600	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
504472000601	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
504472000602	active site
504472000603	trimer interface [polypeptide binding]; other site
504472000604	allosteric site; other site
504472000605	active site lid [active]
504472000606	hexamer (dimer of trimers) interface [polypeptide binding]; other site
504472000607	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
504472000608	putative active site [active]
504472000609	putative metal binding site [ion binding]; other site
504472000610	diaminopimelate decarboxylase; Region: lysA; TIGR01048
504472000611	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
504472000612	active site
504472000613	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
504472000614	substrate binding site [chemical binding]; other site
504472000615	catalytic residues [active]
504472000616	dimer interface [polypeptide binding]; other site
504472000617	hypothetical protein; Provisional; Region: PRK12378
504472000618	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
504472000619	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472000620	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472000621	Uncharacterized conserved protein [Function unknown]; Region: COG2308
504472000622	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
504472000623	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
504472000624	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472000625	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472000626	active site
504472000627	catalytic tetrad [active]
504472000628	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
504472000629	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
504472000630	XisH protein; Region: XisH; pfam08814
504472000631	XisI protein; Region: XisI; pfam08869
504472000632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472000633	Radical SAM superfamily; Region: Radical_SAM; pfam04055
504472000634	FeS/SAM binding site; other site
504472000635	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
504472000636	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
504472000637	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472000638	P-loop; other site
504472000639	Magnesium ion binding site [ion binding]; other site
504472000640	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472000641	Magnesium ion binding site [ion binding]; other site
504472000642	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
504472000643	ParB-like nuclease domain; Region: ParBc; pfam02195
504472000644	dihydrodipicolinate reductase; Provisional; Region: PRK00048
504472000645	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
504472000646	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
504472000647	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
504472000648	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
504472000649	Catalytic site [active]
504472000650	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
504472000651	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
504472000652	ligand binding site [chemical binding]; other site
504472000653	active site
504472000654	UGI interface [polypeptide binding]; other site
504472000655	catalytic site [active]
504472000656	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
504472000657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472000658	S-adenosylmethionine binding site [chemical binding]; other site
504472000659	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
504472000660	helicase 45; Provisional; Region: PTZ00424
504472000661	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
504472000662	ATP binding site [chemical binding]; other site
504472000663	Mg++ binding site [ion binding]; other site
504472000664	motif III; other site
504472000665	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472000666	nucleotide binding region [chemical binding]; other site
504472000667	ATP-binding site [chemical binding]; other site
504472000668	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
504472000669	RNA binding site [nucleotide binding]; other site
504472000670	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
504472000671	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472000672	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
504472000673	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
504472000674	active site
504472000675	intersubunit interface [polypeptide binding]; other site
504472000676	zinc binding site [ion binding]; other site
504472000677	Na+ binding site [ion binding]; other site
504472000678	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472000679	putative active site [active]
504472000680	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472000681	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472000682	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472000683	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472000684	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
504472000685	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472000686	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472000687	ligand binding site [chemical binding]; other site
504472000688	flexible hinge region; other site
504472000689	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
504472000690	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
504472000691	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
504472000692	active site
504472000693	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472000694	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472000695	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472000696	active site
504472000697	metal binding site [ion binding]; metal-binding site
504472000698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
504472000699	MOSC domain; Region: MOSC; pfam03473
504472000700	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000701	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
504472000702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472000703	motif II; other site
504472000704	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
504472000705	MutS domain III; Region: MutS_III; pfam05192
504472000706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472000707	Walker A/P-loop; other site
504472000708	ATP binding site [chemical binding]; other site
504472000709	Q-loop/lid; other site
504472000710	ABC transporter signature motif; other site
504472000711	Walker B; other site
504472000712	D-loop; other site
504472000713	H-loop/switch region; other site
504472000714	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
504472000715	Smr domain; Region: Smr; pfam01713
504472000716	PIN domain; Region: PIN_2; cl17859
504472000717	dimerization interface [polypeptide binding]; other site
504472000718	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
504472000719	putative active cleft [active]
504472000720	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472000721	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472000722	SusD family; Region: SusD; pfam07980
504472000723	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472000724	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000725	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472000726	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000727	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472000728	SusD family; Region: SusD; pfam07980
504472000729	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472000730	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472000731	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472000732	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000733	Domain of unknown function (DUF814); Region: DUF814; pfam05670
504472000734	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
504472000735	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472000736	putative homodimer interface [polypeptide binding]; other site
504472000737	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
504472000738	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472000739	dimer interface [polypeptide binding]; other site
504472000740	putative metal binding site [ion binding]; other site
504472000741	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
504472000742	Zn binding site [ion binding]; other site
504472000743	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472000744	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
504472000745	phosphodiesterase; Provisional; Region: PRK12704
504472000746	KH domain; Region: KH_1; pfam00013
504472000747	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
504472000748	Zn2+ binding site [ion binding]; other site
504472000749	Mg2+ binding site [ion binding]; other site
504472000750	Cell division protein ZapA; Region: ZapA; pfam05164
504472000751	Protein of unknown function (DUF972); Region: DUF972; pfam06156
504472000752	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
504472000753	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
504472000754	putative tRNA-binding site [nucleotide binding]; other site
504472000755	B3/4 domain; Region: B3_4; pfam03483
504472000756	tRNA synthetase B5 domain; Region: B5; smart00874
504472000757	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
504472000758	dimer interface [polypeptide binding]; other site
504472000759	motif 1; other site
504472000760	motif 3; other site
504472000761	motif 2; other site
504472000762	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
504472000763	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
504472000764	WxcM-like, C-terminal; Region: FdtA; pfam05523
504472000765	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
504472000766	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
504472000767	inhibitor-cofactor binding pocket; inhibition site
504472000768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472000769	catalytic residue [active]
504472000770	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
504472000771	Ligand binding site; other site
504472000772	Putative Catalytic site; other site
504472000773	DXD motif; other site
504472000774	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472000775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472000776	S-adenosylmethionine binding site [chemical binding]; other site
504472000777	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
504472000778	Lumazine binding domain; Region: Lum_binding; pfam00677
504472000779	Lumazine binding domain; Region: Lum_binding; pfam00677
504472000780	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
504472000781	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
504472000782	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
504472000783	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472000784	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472000785	active site residue [active]
504472000786	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
504472000787	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
504472000788	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472000789	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472000790	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
504472000791	dimer interface [polypeptide binding]; other site
504472000792	putative inhibitory loop; other site
504472000793	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472000794	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
504472000795	catalytic triad [active]
504472000796	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
504472000797	BON domain; Region: BON; pfam04972
504472000798	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472000799	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
504472000800	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
504472000801	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
504472000802	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
504472000803	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
504472000804	metal binding site [ion binding]; metal-binding site
504472000805	dimer interface [polypeptide binding]; other site
504472000806	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472000807	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472000808	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472000809	DNA binding residues [nucleotide binding]
504472000810	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
504472000811	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
504472000812	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
504472000813	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
504472000814	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
504472000815	ligand binding site [chemical binding]; other site
504472000816	short chain dehydrogenase; Provisional; Region: PRK08628
504472000817	classical (c) SDRs; Region: SDR_c; cd05233
504472000818	NAD(P) binding site [chemical binding]; other site
504472000819	active site
504472000820	Domain of unknown function (DUF718); Region: DUF718; pfam05336
504472000821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472000822	non-specific DNA binding site [nucleotide binding]; other site
504472000823	salt bridge; other site
504472000824	sequence-specific DNA binding site [nucleotide binding]; other site
504472000825	Predicted acyl esterases [General function prediction only]; Region: COG2936
504472000826	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
504472000827	Domain of unknown function (DUF427); Region: DUF427; pfam04248
504472000828	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
504472000829	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
504472000830	Walker A/P-loop; other site
504472000831	ATP binding site [chemical binding]; other site
504472000832	Q-loop/lid; other site
504472000833	ABC transporter signature motif; other site
504472000834	Walker B; other site
504472000835	D-loop; other site
504472000836	H-loop/switch region; other site
504472000837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
504472000838	dimer interface [polypeptide binding]; other site
504472000839	conserved gate region; other site
504472000840	putative PBP binding loops; other site
504472000841	ABC-ATPase subunit interface; other site
504472000842	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
504472000843	active site
504472000844	DNA binding site [nucleotide binding]
504472000845	PIN domain; Region: PIN_2; cl17859
504472000846	hypothetical protein; Provisional; Region: PRK11820
504472000847	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
504472000848	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
504472000849	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
504472000850	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
504472000851	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
504472000852	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
504472000853	NAD binding site [chemical binding]; other site
504472000854	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
504472000855	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
504472000856	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
504472000857	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
504472000858	Domain of unknown function DUF11; Region: DUF11; pfam01345
504472000859	Domain of unknown function DUF11; Region: DUF11; pfam01345
504472000860	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
504472000861	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
504472000862	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472000863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472000864	active site
504472000865	phosphorylation site [posttranslational modification]
504472000866	intermolecular recognition site; other site
504472000867	dimerization interface [polypeptide binding]; other site
504472000868	LytTr DNA-binding domain; Region: LytTR; smart00850
504472000869	Histidine kinase; Region: His_kinase; pfam06580
504472000870	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472000871	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472000872	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472000873	Uncharacterized conserved protein [Function unknown]; Region: COG2353
504472000874	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472000875	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472000876	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472000877	Cytochrome c; Region: Cytochrom_C; cl11414
504472000878	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472000879	metal binding site [ion binding]; metal-binding site
504472000880	ligand binding site [chemical binding]; other site
504472000881	hypothetical protein; Provisional; Region: PRK07538
504472000882	hypothetical protein; Provisional; Region: PRK07236
504472000883	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
504472000884	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472000885	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
504472000886	dimerization interface [polypeptide binding]; other site
504472000887	substrate binding pocket [chemical binding]; other site
504472000888	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
504472000889	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
504472000890	metal ion-dependent adhesion site (MIDAS); other site
504472000891	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472000892	putative active site [active]
504472000893	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
504472000894	DinB superfamily; Region: DinB_2; pfam12867
504472000895	DinB family; Region: DinB; cl17821
504472000896	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
504472000897	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
504472000898	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
504472000899	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472000900	Sulfatase; Region: Sulfatase; pfam00884
504472000901	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
504472000902	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472000903	metal binding site [ion binding]; metal-binding site
504472000904	trehalose synthase; Region: treS_nterm; TIGR02456
504472000905	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
504472000906	Ca binding site [ion binding]; other site
504472000907	active site
504472000908	catalytic site [active]
504472000909	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
504472000910	active site
504472000911	intersubunit interactions; other site
504472000912	catalytic residue [active]
504472000913	xylose isomerase; Provisional; Region: PRK05474
504472000914	xylose isomerase; Region: xylose_isom_A; TIGR02630
504472000915	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
504472000916	nudix motif; other site
504472000917	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
504472000918	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
504472000919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472000920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472000921	DNA binding site [nucleotide binding]
504472000922	domain linker motif; other site
504472000923	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472000924	dimerization interface [polypeptide binding]; other site
504472000925	ligand binding site [chemical binding]; other site
504472000926	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
504472000927	substrate binding site [chemical binding]; other site
504472000928	active site
504472000929	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
504472000930	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
504472000931	putative active site [active]
504472000932	putative metal binding site [ion binding]; other site
504472000933	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
504472000934	nudix motif; other site
504472000935	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472000936	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472000937	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
504472000938	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
504472000939	NAD(P) binding site [chemical binding]; other site
504472000940	active site
504472000941	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
504472000942	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
504472000943	putative NAD(P) binding site [chemical binding]; other site
504472000944	putative substrate binding site [chemical binding]; other site
504472000945	catalytic Zn binding site [ion binding]; other site
504472000946	structural Zn binding site [ion binding]; other site
504472000947	dimer interface [polypeptide binding]; other site
504472000948	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
504472000949	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
504472000950	active site
504472000951	catalytic site [active]
504472000952	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472000953	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
504472000954	active site
504472000955	dimer interface [polypeptide binding]; other site
504472000956	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472000957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472000958	Coenzyme A binding pocket [chemical binding]; other site
504472000959	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
504472000960	MarR family; Region: MarR_2; cl17246
504472000961	Uncharacterized conserved protein [Function unknown]; Region: COG2353
504472000962	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
504472000963	AMP nucleosidase; Provisional; Region: PRK07115
504472000964	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
504472000965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472000966	binding surface
504472000967	TPR motif; other site
504472000968	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472000969	binding surface
504472000970	TPR motif; other site
504472000971	TPR repeat; Region: TPR_11; pfam13414
504472000972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472000973	binding surface
504472000974	TPR motif; other site
504472000975	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
504472000976	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
504472000977	putative dimer interface [polypeptide binding]; other site
504472000978	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
504472000979	active site
504472000980	H+ Antiporter protein; Region: 2A0121; TIGR00900
504472000981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472000982	putative substrate translocation pore; other site
504472000983	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
504472000984	argininosuccinate lyase; Provisional; Region: PRK00855
504472000985	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
504472000986	active sites [active]
504472000987	tetramer interface [polypeptide binding]; other site
504472000988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472000989	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472000990	putative substrate translocation pore; other site
504472000991	Protein of unknown function, DUF606; Region: DUF606; pfam04657
504472000992	Ureide permease; Region: Ureide_permease; pfam07168
504472000993	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
504472000994	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
504472000995	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
504472000996	GAF domain; Region: GAF; pfam01590
504472000997	Phytochrome region; Region: PHY; pfam00360
504472000998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472000999	dimer interface [polypeptide binding]; other site
504472001000	phosphorylation site [posttranslational modification]
504472001001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001002	ATP binding site [chemical binding]; other site
504472001003	Mg2+ binding site [ion binding]; other site
504472001004	G-X-G motif; other site
504472001005	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472001006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001007	active site
504472001008	phosphorylation site [posttranslational modification]
504472001009	intermolecular recognition site; other site
504472001010	dimerization interface [polypeptide binding]; other site
504472001011	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
504472001012	heme binding pocket [chemical binding]; other site
504472001013	heme ligand [chemical binding]; other site
504472001014	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472001015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001016	putative active site [active]
504472001017	heme pocket [chemical binding]; other site
504472001018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001019	putative active site [active]
504472001020	heme pocket [chemical binding]; other site
504472001021	PAS domain S-box; Region: sensory_box; TIGR00229
504472001022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001023	dimer interface [polypeptide binding]; other site
504472001024	phosphorylation site [posttranslational modification]
504472001025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001026	ATP binding site [chemical binding]; other site
504472001027	Mg2+ binding site [ion binding]; other site
504472001028	G-X-G motif; other site
504472001029	Low affinity iron permease; Region: Iron_permease; pfam04120
504472001030	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472001031	catalytic residues [active]
504472001032	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472001033	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472001034	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472001035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472001036	Walker A/P-loop; other site
504472001037	ATP binding site [chemical binding]; other site
504472001038	Q-loop/lid; other site
504472001039	ABC transporter signature motif; other site
504472001040	Walker B; other site
504472001041	D-loop; other site
504472001042	H-loop/switch region; other site
504472001043	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
504472001044	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
504472001045	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472001046	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472001047	ligand binding site [chemical binding]; other site
504472001048	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472001049	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472001050	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472001051	NIPSNAP; Region: NIPSNAP; pfam07978
504472001052	NIPSNAP; Region: NIPSNAP; pfam07978
504472001053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
504472001054	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
504472001055	glycogen branching enzyme; Provisional; Region: PRK12313
504472001056	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
504472001057	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
504472001058	active site
504472001059	catalytic site [active]
504472001060	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
504472001061	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
504472001062	Domain of unknown function (DUF370); Region: DUF370; cl00898
504472001063	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
504472001064	SnoaL-like domain; Region: SnoaL_3; pfam13474
504472001065	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
504472001066	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
504472001067	NAD(P) binding site [chemical binding]; other site
504472001068	homotetramer interface [polypeptide binding]; other site
504472001069	homodimer interface [polypeptide binding]; other site
504472001070	active site
504472001071	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
504472001072	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
504472001073	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
504472001074	HD domain; Region: HD_4; pfam13328
504472001075	argininosuccinate synthase; Provisional; Region: PRK13820
504472001076	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
504472001077	Ligand Binding Site [chemical binding]; other site
504472001078	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472001079	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472001080	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
504472001081	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
504472001082	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472001083	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472001084	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
504472001085	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
504472001086	N- and C-terminal domain interface [polypeptide binding]; other site
504472001087	active site
504472001088	catalytic site [active]
504472001089	metal binding site [ion binding]; metal-binding site
504472001090	carbohydrate binding site [chemical binding]; other site
504472001091	ATP binding site [chemical binding]; other site
504472001092	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
504472001093	Amidohydrolase; Region: Amidohydro_2; pfam04909
504472001094	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
504472001095	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
504472001096	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472001097	putative active site [active]
504472001098	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
504472001099	classical (c) SDRs; Region: SDR_c; cd05233
504472001100	NAD(P) binding site [chemical binding]; other site
504472001101	active site
504472001102	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
504472001103	galactarate dehydratase; Region: galactar-dH20; TIGR03248
504472001104	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
504472001105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
504472001106	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
504472001107	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472001108	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
504472001109	active site
504472001110	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
504472001111	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472001112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472001113	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472001114	DNA binding residues [nucleotide binding]
504472001115	recombination factor protein RarA; Reviewed; Region: PRK13342
504472001116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472001117	Walker A motif; other site
504472001118	ATP binding site [chemical binding]; other site
504472001119	Walker B motif; other site
504472001120	arginine finger; other site
504472001121	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
504472001122	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
504472001123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001124	active site
504472001125	phosphorylation site [posttranslational modification]
504472001126	intermolecular recognition site; other site
504472001127	dimerization interface [polypeptide binding]; other site
504472001128	LytTr DNA-binding domain; Region: LytTR; smart00850
504472001129	Histidine kinase; Region: His_kinase; pfam06580
504472001130	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
504472001131	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
504472001132	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
504472001133	putative catalytic cysteine [active]
504472001134	gamma-glutamyl kinase; Provisional; Region: PRK05429
504472001135	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
504472001136	nucleotide binding site [chemical binding]; other site
504472001137	homotetrameric interface [polypeptide binding]; other site
504472001138	putative phosphate binding site [ion binding]; other site
504472001139	putative allosteric binding site; other site
504472001140	PUA domain; Region: PUA; pfam01472
504472001141	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
504472001142	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
504472001143	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
504472001144	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
504472001145	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
504472001146	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
504472001147	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
504472001148	Methane oxygenase PmoA; Region: PmoA; pfam14100
504472001149	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
504472001150	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
504472001151	potential catalytic triad [active]
504472001152	conserved cys residue [active]
504472001153	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
504472001154	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
504472001155	active site
504472001156	dimer interface [polypeptide binding]; other site
504472001157	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
504472001158	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472001159	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472001160	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472001161	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472001162	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472001163	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472001164	SusD family; Region: SusD; pfam07980
504472001165	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472001166	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472001167	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472001168	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472001169	FecR protein; Region: FecR; pfam04773
504472001170	OsmC-like protein; Region: OsmC; pfam02566
504472001171	lipoyl synthase; Provisional; Region: PRK05481
504472001172	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472001173	FeS/SAM binding site; other site
504472001174	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
504472001175	lycopene cyclase; Region: lycopene_cycl; TIGR01789
504472001176	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472001177	Two component regulator propeller; Region: Reg_prop; pfam07494
504472001178	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472001179	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001181	dimer interface [polypeptide binding]; other site
504472001182	phosphorylation site [posttranslational modification]
504472001183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001184	ATP binding site [chemical binding]; other site
504472001185	Mg2+ binding site [ion binding]; other site
504472001186	G-X-G motif; other site
504472001187	S-adenosylmethionine synthetase; Validated; Region: PRK05250
504472001188	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
504472001189	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
504472001190	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
504472001191	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
504472001192	30S subunit binding site; other site
504472001193	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
504472001194	Cytochrome P450; Region: p450; pfam00067
504472001195	short chain dehydrogenase; Provisional; Region: PRK06701
504472001196	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
504472001197	NAD binding site [chemical binding]; other site
504472001198	metal binding site [ion binding]; metal-binding site
504472001199	active site
504472001200	short chain dehydrogenase; Provisional; Region: PRK06701
504472001201	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
504472001202	NAD binding site [chemical binding]; other site
504472001203	metal binding site [ion binding]; metal-binding site
504472001204	active site
504472001205	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472001206	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472001207	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472001208	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
504472001209	SnoaL-like domain; Region: SnoaL_3; pfam13474
504472001210	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
504472001211	short chain dehydrogenase; Provisional; Region: PRK07326
504472001212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472001213	NAD(P) binding site [chemical binding]; other site
504472001214	active site
504472001215	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
504472001216	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
504472001217	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
504472001218	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
504472001219	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472001220	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472001221	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472001222	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472001223	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
504472001224	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472001225	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472001226	catalytic residues [active]
504472001227	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
504472001228	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
504472001229	DNA binding residues [nucleotide binding]
504472001230	dimer interface [polypeptide binding]; other site
504472001231	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
504472001232	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472001233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001234	active site
504472001235	phosphorylation site [posttranslational modification]
504472001236	intermolecular recognition site; other site
504472001237	dimerization interface [polypeptide binding]; other site
504472001238	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472001239	DNA binding site [nucleotide binding]
504472001240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001241	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001242	dimer interface [polypeptide binding]; other site
504472001243	phosphorylation site [posttranslational modification]
504472001244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001245	ATP binding site [chemical binding]; other site
504472001246	Mg2+ binding site [ion binding]; other site
504472001247	G-X-G motif; other site
504472001248	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
504472001249	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472001250	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472001251	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
504472001252	putative active site [active]
504472001253	dimerization interface [polypeptide binding]; other site
504472001254	putative tRNAtyr binding site [nucleotide binding]; other site
504472001255	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
504472001256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472001257	S-adenosylmethionine binding site [chemical binding]; other site
504472001258	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
504472001259	N-acetyl-D-glucosamine binding site [chemical binding]; other site
504472001260	catalytic residue [active]
504472001261	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472001262	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472001263	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472001264	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
504472001265	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
504472001266	DNA binding site [nucleotide binding]
504472001267	active site
504472001268	Predicted flavoprotein [General function prediction only]; Region: COG0431
504472001269	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
504472001270	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
504472001271	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
504472001272	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472001273	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
504472001274	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
504472001275	active site
504472001276	dimer interface [polypeptide binding]; other site
504472001277	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
504472001278	dimer interface [polypeptide binding]; other site
504472001279	active site
504472001280	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
504472001281	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
504472001282	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
504472001283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472001284	NAD(P) binding site [chemical binding]; other site
504472001285	active site
504472001286	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472001287	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472001288	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
504472001289	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472001290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472001291	putative substrate translocation pore; other site
504472001292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472001293	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
504472001294	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
504472001295	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472001296	PIN domain; Region: PIN_3; cl17397
504472001297	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
504472001298	Clp amino terminal domain; Region: Clp_N; pfam02861
504472001299	Clp amino terminal domain; Region: Clp_N; pfam02861
504472001300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472001301	Walker A motif; other site
504472001302	ATP binding site [chemical binding]; other site
504472001303	Walker B motif; other site
504472001304	arginine finger; other site
504472001305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472001306	Walker A motif; other site
504472001307	ATP binding site [chemical binding]; other site
504472001308	Walker B motif; other site
504472001309	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
504472001310	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
504472001311	classical (c) SDRs; Region: SDR_c; cd05233
504472001312	NAD(P) binding site [chemical binding]; other site
504472001313	active site
504472001314	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
504472001315	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
504472001316	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472001317	ligand binding site [chemical binding]; other site
504472001318	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
504472001319	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
504472001320	generic binding surface II; other site
504472001321	generic binding surface I; other site
504472001322	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
504472001323	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
504472001324	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
504472001325	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
504472001326	dimer interface [polypeptide binding]; other site
504472001327	motif 1; other site
504472001328	active site
504472001329	motif 2; other site
504472001330	motif 3; other site
504472001331	LytTr DNA-binding domain; Region: LytTR; smart00850
504472001332	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472001333	LytTr DNA-binding domain; Region: LytTR; smart00850
504472001334	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472001335	DNA repair protein RadA; Provisional; Region: PRK11823
504472001336	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
504472001337	Walker A motif/ATP binding site; other site
504472001338	ATP binding site [chemical binding]; other site
504472001339	Walker B motif; other site
504472001340	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
504472001341	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472001342	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472001343	TAP-like protein; Region: Abhydrolase_4; pfam08386
504472001344	Cupin domain; Region: Cupin_2; pfam07883
504472001345	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472001346	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472001347	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472001348	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472001349	DNA interaction; other site
504472001350	Metal-binding active site; metal-binding site
504472001351	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472001352	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472001353	Trehalose utilisation; Region: ThuA; pfam06283
504472001354	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472001355	HEAT repeats; Region: HEAT_2; pfam13646
504472001356	CARDB; Region: CARDB; pfam07705
504472001357	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
504472001358	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001359	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001360	dimer interface [polypeptide binding]; other site
504472001361	phosphorylation site [posttranslational modification]
504472001362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001363	ATP binding site [chemical binding]; other site
504472001364	Mg2+ binding site [ion binding]; other site
504472001365	G-X-G motif; other site
504472001366	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
504472001367	Bacterial PH domain; Region: DUF304; pfam03703
504472001368	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
504472001369	MutS domain I; Region: MutS_I; pfam01624
504472001370	MutS domain II; Region: MutS_II; pfam05188
504472001371	MutS domain III; Region: MutS_III; pfam05192
504472001372	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
504472001373	Walker A/P-loop; other site
504472001374	ATP binding site [chemical binding]; other site
504472001375	Q-loop/lid; other site
504472001376	ABC transporter signature motif; other site
504472001377	Walker B; other site
504472001378	D-loop; other site
504472001379	H-loop/switch region; other site
504472001380	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
504472001381	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472001382	PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121
504472001383	apical/protease domain interface [polypeptide binding]; other site
504472001384	substrate binding [chemical binding]; other site
504472001385	dimer interface [polypeptide binding]; other site
504472001386	M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022
504472001387	dimer interface [polypeptide binding]; other site
504472001388	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472001389	active site
504472001390	metal binding site [ion binding]; metal-binding site
504472001391	Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253
504472001392	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
504472001393	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
504472001394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472001395	putative substrate translocation pore; other site
504472001396	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
504472001397	putative active site [active]
504472001398	putative catalytic site [active]
504472001399	putative DNA binding site [nucleotide binding]; other site
504472001400	putative phosphate binding site [ion binding]; other site
504472001401	metal binding site A [ion binding]; metal-binding site
504472001402	putative AP binding site [nucleotide binding]; other site
504472001403	putative metal binding site B [ion binding]; other site
504472001404	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
504472001405	pseudouridine synthase; Region: TIGR00093
504472001406	active site
504472001407	hypothetical protein; Reviewed; Region: PRK00024
504472001408	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
504472001409	MPN+ (JAMM) motif; other site
504472001410	Zinc-binding site [ion binding]; other site
504472001411	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
504472001412	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
504472001413	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
504472001414	Zn binding site [ion binding]; other site
504472001415	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472001416	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
504472001417	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
504472001418	putative RNA binding site [nucleotide binding]; other site
504472001419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472001420	S-adenosylmethionine binding site [chemical binding]; other site
504472001421	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472001422	E3 interaction surface; other site
504472001423	lipoyl attachment site [posttranslational modification]; other site
504472001424	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
504472001425	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472001426	E3 interaction surface; other site
504472001427	lipoyl attachment site [posttranslational modification]; other site
504472001428	e3 binding domain; Region: E3_binding; pfam02817
504472001429	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
504472001430	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472001431	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472001432	catalytic residues [active]
504472001433	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
504472001434	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
504472001435	active site
504472001436	PHP Thumb interface [polypeptide binding]; other site
504472001437	metal binding site [ion binding]; metal-binding site
504472001438	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
504472001439	generic binding surface II; other site
504472001440	generic binding surface I; other site
504472001441	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
504472001442	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
504472001443	NIPSNAP; Region: NIPSNAP; pfam07978
504472001444	NIPSNAP; Region: NIPSNAP; pfam07978
504472001445	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
504472001446	active site
504472001447	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472001448	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472001449	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
504472001450	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472001451	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472001452	Fasciclin domain; Region: Fasciclin; pfam02469
504472001453	Fasciclin domain; Region: Fasciclin; pfam02469
504472001454	5'-3' exonuclease; Region: 53EXOc; smart00475
504472001455	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
504472001456	active site
504472001457	metal binding site 1 [ion binding]; metal-binding site
504472001458	putative 5' ssDNA interaction site; other site
504472001459	metal binding site 3; metal-binding site
504472001460	metal binding site 2 [ion binding]; metal-binding site
504472001461	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
504472001462	putative DNA binding site [nucleotide binding]; other site
504472001463	putative metal binding site [ion binding]; other site
504472001464	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
504472001465	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
504472001466	active site
504472001467	catalytic site [active]
504472001468	substrate binding site [chemical binding]; other site
504472001469	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
504472001470	active site
504472001471	DNA binding site [nucleotide binding]
504472001472	catalytic site [active]
504472001473	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472001474	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472001475	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472001476	binding surface
504472001477	TPR repeat; Region: TPR_11; pfam13414
504472001478	TPR motif; other site
504472001479	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
504472001480	MFS transport protein AraJ; Provisional; Region: PRK10091
504472001481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472001482	putative substrate translocation pore; other site
504472001483	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
504472001484	SPFH domain / Band 7 family; Region: Band_7; pfam01145
504472001485	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472001486	Ligand Binding Site [chemical binding]; other site
504472001487	OsmC-like protein; Region: OsmC; cl00767
504472001488	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472001489	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472001490	Two component regulator propeller; Region: Reg_prop; pfam07494
504472001491	Two component regulator propeller; Region: Reg_prop; pfam07494
504472001492	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472001493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001494	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001495	dimer interface [polypeptide binding]; other site
504472001496	phosphorylation site [posttranslational modification]
504472001497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001498	ATP binding site [chemical binding]; other site
504472001499	Mg2+ binding site [ion binding]; other site
504472001500	G-X-G motif; other site
504472001501	Response regulator receiver domain; Region: Response_reg; pfam00072
504472001502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001503	active site
504472001504	phosphorylation site [posttranslational modification]
504472001505	intermolecular recognition site; other site
504472001506	dimerization interface [polypeptide binding]; other site
504472001507	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472001508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472001509	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
504472001510	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472001511	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472001512	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472001513	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472001514	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472001515	SusD family; Region: SusD; pfam07980
504472001516	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
504472001517	N-terminal domain of PARMER_03128; Region: PARMER_03128_N; cd12106
504472001518	Bacterial proteins similar to Porphyromonas gingivalis HmuY and the C-terminal domain of PARMER_03218; Region: HmuY_like; cd07472
504472001519	Alginate lyase; Region: Alginate_lyase; pfam05426
504472001520	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
504472001521	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472001522	DNA-binding site [nucleotide binding]; DNA binding site
504472001523	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
504472001524	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472001525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472001526	homodimer interface [polypeptide binding]; other site
504472001527	catalytic residue [active]
504472001528	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
504472001529	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
504472001530	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
504472001531	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472001532	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
504472001533	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
504472001534	DNA binding site [nucleotide binding]
504472001535	active site
504472001536	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
504472001537	active site
504472001538	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
504472001539	dimer interface [polypeptide binding]; other site
504472001540	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
504472001541	Ligand Binding Site [chemical binding]; other site
504472001542	Molecular Tunnel; other site
504472001543	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
504472001544	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
504472001545	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472001546	integral membrane protein; Region: integ_memb_HG; TIGR03954
504472001547	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
504472001548	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
504472001549	Zn binding site [ion binding]; other site
504472001550	Sister chromatid cohesion C-terminus; Region: Nipped-B_C; pfam12830
504472001551	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
504472001552	catalytic core [active]
504472001553	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472001554	Sulfatase; Region: Sulfatase; pfam00884
504472001555	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
504472001556	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472001557	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472001558	Walker A motif; other site
504472001559	ATP binding site [chemical binding]; other site
504472001560	Walker B motif; other site
504472001561	arginine finger; other site
504472001562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472001563	binding surface
504472001564	TPR motif; other site
504472001565	TPR repeat; Region: TPR_11; pfam13414
504472001566	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
504472001567	CHAT domain; Region: CHAT; pfam12770
504472001568	Trehalose utilisation; Region: ThuA; pfam06283
504472001569	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472001570	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472001571	PAS domain S-box; Region: sensory_box; TIGR00229
504472001572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001573	putative active site [active]
504472001574	heme pocket [chemical binding]; other site
504472001575	PAS fold; Region: PAS_3; pfam08447
504472001576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001577	heme pocket [chemical binding]; other site
504472001578	putative active site [active]
504472001579	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001580	PAS domain; Region: PAS_9; pfam13426
504472001581	putative active site [active]
504472001582	heme pocket [chemical binding]; other site
504472001583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001584	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001585	dimer interface [polypeptide binding]; other site
504472001586	phosphorylation site [posttranslational modification]
504472001587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001588	ATP binding site [chemical binding]; other site
504472001589	Mg2+ binding site [ion binding]; other site
504472001590	G-X-G motif; other site
504472001591	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472001592	DinB superfamily; Region: DinB_2; pfam12867
504472001593	DNA photolyase; Region: DNA_photolyase; pfam00875
504472001594	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
504472001595	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
504472001596	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
504472001597	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
504472001598	inhibitor-cofactor binding pocket; inhibition site
504472001599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472001600	catalytic residue [active]
504472001601	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472001602	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472001603	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
504472001604	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472001605	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
504472001606	active site
504472001607	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
504472001608	classical (c) SDRs; Region: SDR_c; cd05233
504472001609	NAD(P) binding site [chemical binding]; other site
504472001610	active site
504472001611	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
504472001612	inhibitor site; inhibition site
504472001613	active site
504472001614	dimer interface [polypeptide binding]; other site
504472001615	catalytic residue [active]
504472001616	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
504472001617	EamA-like transporter family; Region: EamA; pfam00892
504472001618	EamA-like transporter family; Region: EamA; pfam00892
504472001619	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
504472001620	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
504472001621	metal binding site [ion binding]; metal-binding site
504472001622	substrate binding pocket [chemical binding]; other site
504472001623	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
504472001624	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
504472001625	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
504472001626	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472001627	homotrimer interaction site [polypeptide binding]; other site
504472001628	putative active site [active]
504472001629	Creatinine amidohydrolase; Region: Creatininase; pfam02633
504472001630	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472001631	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472001632	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472001633	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472001634	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472001635	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472001636	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
504472001637	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472001638	Transcriptional regulators [Transcription]; Region: GntR; COG1802
504472001639	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472001640	DNA-binding site [nucleotide binding]; DNA binding site
504472001641	FCD domain; Region: FCD; pfam07729
504472001642	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472001643	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
504472001644	PAS domain S-box; Region: sensory_box; TIGR00229
504472001645	PAS domain S-box; Region: sensory_box; TIGR00229
504472001646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001647	putative active site [active]
504472001648	heme pocket [chemical binding]; other site
504472001649	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472001650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001651	heme pocket [chemical binding]; other site
504472001652	putative active site [active]
504472001653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001654	putative active site [active]
504472001655	heme pocket [chemical binding]; other site
504472001656	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472001657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001658	putative active site [active]
504472001659	heme pocket [chemical binding]; other site
504472001660	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001661	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001662	dimer interface [polypeptide binding]; other site
504472001663	phosphorylation site [posttranslational modification]
504472001664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001665	ATP binding site [chemical binding]; other site
504472001666	Mg2+ binding site [ion binding]; other site
504472001667	G-X-G motif; other site
504472001668	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
504472001669	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472001670	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472001671	DNA binding residues [nucleotide binding]
504472001672	dimerization interface [polypeptide binding]; other site
504472001673	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472001674	GAF domain; Region: GAF; pfam01590
504472001675	PAS domain S-box; Region: sensory_box; TIGR00229
504472001676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001677	putative active site [active]
504472001678	heme pocket [chemical binding]; other site
504472001679	PAS domain S-box; Region: sensory_box; TIGR00229
504472001680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472001681	putative active site [active]
504472001682	heme pocket [chemical binding]; other site
504472001683	PAS domain; Region: PAS_9; pfam13426
504472001684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001685	dimer interface [polypeptide binding]; other site
504472001686	phosphorylation site [posttranslational modification]
504472001687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001688	ATP binding site [chemical binding]; other site
504472001689	Mg2+ binding site [ion binding]; other site
504472001690	G-X-G motif; other site
504472001691	Response regulator receiver domain; Region: Response_reg; pfam00072
504472001692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001693	active site
504472001694	phosphorylation site [posttranslational modification]
504472001695	intermolecular recognition site; other site
504472001696	dimerization interface [polypeptide binding]; other site
504472001697	Response regulator receiver domain; Region: Response_reg; pfam00072
504472001698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001699	active site
504472001700	phosphorylation site [posttranslational modification]
504472001701	intermolecular recognition site; other site
504472001702	dimerization interface [polypeptide binding]; other site
504472001703	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
504472001704	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472001705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472001706	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472001707	beta-D-glucuronidase; Provisional; Region: PRK10150
504472001708	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
504472001709	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
504472001710	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
504472001711	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
504472001712	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
504472001713	active site
504472001714	NTP binding site [chemical binding]; other site
504472001715	nucleic acid binding site [nucleotide binding]; other site
504472001716	enoyl-CoA hydratase; Provisional; Region: PRK06688
504472001717	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472001718	substrate binding site [chemical binding]; other site
504472001719	oxyanion hole (OAH) forming residues; other site
504472001720	trimer interface [polypeptide binding]; other site
504472001721	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
504472001722	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
504472001723	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
504472001724	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
504472001725	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
504472001726	active site
504472001727	polynucleotide kinase; Provisional; Region: pseT; PHA02530
504472001728	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
504472001729	active site
504472001730	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472001731	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
504472001732	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472001733	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472001734	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472001735	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
504472001736	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
504472001737	active site
504472001738	catalytic site [active]
504472001739	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472001740	NAD+ synthase (glutamine-hydrolysing); Region: PLN02339
504472001741	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
504472001742	multimer interface [polypeptide binding]; other site
504472001743	active site
504472001744	catalytic triad [active]
504472001745	protein interface 1 [polypeptide binding]; other site
504472001746	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
504472001747	Ligand Binding Site [chemical binding]; other site
504472001748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472001749	AAA domain; Region: AAA_21; pfam13304
504472001750	Walker A motif; other site
504472001751	ATP binding site [chemical binding]; other site
504472001752	EamA-like transporter family; Region: EamA; pfam00892
504472001753	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
504472001754	EamA-like transporter family; Region: EamA; pfam00892
504472001755	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472001756	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472001757	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472001758	ligand binding site [chemical binding]; other site
504472001759	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
504472001760	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
504472001761	dimer interface [polypeptide binding]; other site
504472001762	decamer (pentamer of dimers) interface [polypeptide binding]; other site
504472001763	catalytic triad [active]
504472001764	peroxidatic and resolving cysteines [active]
504472001765	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
504472001766	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
504472001767	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472001768	Cytochrome c; Region: Cytochrom_C; pfam00034
504472001769	ferrochelatase; Reviewed; Region: hemH; PRK00035
504472001770	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
504472001771	C-terminal domain interface [polypeptide binding]; other site
504472001772	active site
504472001773	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
504472001774	active site
504472001775	N-terminal domain interface [polypeptide binding]; other site
504472001776	Transcriptional regulator [Transcription]; Region: LysR; COG0583
504472001777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472001778	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
504472001779	dimerization interface [polypeptide binding]; other site
504472001780	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
504472001781	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
504472001782	nudix motif; other site
504472001783	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
504472001784	Carboxylesterase family; Region: COesterase; pfam00135
504472001785	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472001786	substrate binding pocket [chemical binding]; other site
504472001787	catalytic triad [active]
504472001788	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472001789	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
504472001790	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
504472001791	Glutamine amidotransferase class-I; Region: GATase; pfam00117
504472001792	glutamine binding [chemical binding]; other site
504472001793	catalytic triad [active]
504472001794	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472001795	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
504472001796	FOG: CBS domain [General function prediction only]; Region: COG0517
504472001797	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911
504472001798	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
504472001799	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
504472001800	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
504472001801	Predicted amidohydrolase [General function prediction only]; Region: COG0388
504472001802	active site
504472001803	catalytic triad [active]
504472001804	dimer interface [polypeptide binding]; other site
504472001805	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
504472001806	Domain of unknown function DUF20; Region: UPF0118; pfam01594
504472001807	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
504472001808	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
504472001809	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
504472001810	active site
504472001811	NTP binding site [chemical binding]; other site
504472001812	metal binding triad [ion binding]; metal-binding site
504472001813	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
504472001814	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
504472001815	Zn2+ binding site [ion binding]; other site
504472001816	Mg2+ binding site [ion binding]; other site
504472001817	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
504472001818	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472001819	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
504472001820	DNA-binding site [nucleotide binding]; DNA binding site
504472001821	RNA-binding motif; other site
504472001822	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
504472001823	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
504472001824	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
504472001825	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
504472001826	RNA binding site [nucleotide binding]; other site
504472001827	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
504472001828	NlpC/P60 family; Region: NLPC_P60; pfam00877
504472001829	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
504472001830	GIY-YIG motif/motif A; other site
504472001831	putative active site [active]
504472001832	putative metal binding site [ion binding]; other site
504472001833	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472001834	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
504472001835	active site
504472001836	catalytic residues [active]
504472001837	DNA binding site [nucleotide binding]
504472001838	Int/Topo IB signature motif; other site
504472001839	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
504472001840	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472001841	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
504472001842	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
504472001843	catalytic residue [active]
504472001844	Annexin repeats; Region: ANX; smart00335
504472001845	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
504472001846	AAA domain; Region: AAA_25; pfam13481
504472001847	recA bacterial DNA recombination protein; Region: RecA; cl17211
504472001848	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
504472001849	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472001850	Histidine kinase; Region: HisKA_3; pfam07730
504472001851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001852	ATP binding site [chemical binding]; other site
504472001853	Mg2+ binding site [ion binding]; other site
504472001854	G-X-G motif; other site
504472001855	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472001856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001857	active site
504472001858	phosphorylation site [posttranslational modification]
504472001859	intermolecular recognition site; other site
504472001860	dimerization interface [polypeptide binding]; other site
504472001861	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472001862	DNA binding residues [nucleotide binding]
504472001863	dimerization interface [polypeptide binding]; other site
504472001864	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
504472001865	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
504472001866	dimer interface [polypeptide binding]; other site
504472001867	decamer (pentamer of dimers) interface [polypeptide binding]; other site
504472001868	catalytic triad [active]
504472001869	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
504472001870	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
504472001871	active site
504472001872	Uncharacterized conserved protein [Function unknown]; Region: COG1359
504472001873	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
504472001874	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
504472001875	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
504472001876	shikimate binding site; other site
504472001877	NAD(P) binding site [chemical binding]; other site
504472001878	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
504472001879	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
504472001880	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
504472001881	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
504472001882	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
504472001883	CoenzymeA binding site [chemical binding]; other site
504472001884	subunit interaction site [polypeptide binding]; other site
504472001885	PHB binding site; other site
504472001886	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
504472001887	trimer interface [polypeptide binding]; other site
504472001888	putative Zn binding site [ion binding]; other site
504472001889	Bifunctional nuclease; Region: DNase-RNase; pfam02577
504472001890	UvrB/uvrC motif; Region: UVR; pfam02151
504472001891	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
504472001892	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
504472001893	Ligand Binding Site [chemical binding]; other site
504472001894	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
504472001895	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
504472001896	Ligand binding site [chemical binding]; other site
504472001897	Electron transfer flavoprotein domain; Region: ETF; pfam01012
504472001898	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
504472001899	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
504472001900	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
504472001901	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
504472001902	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472001903	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
504472001904	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
504472001905	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
504472001906	trimer interface [polypeptide binding]; other site
504472001907	active site
504472001908	substrate binding site [chemical binding]; other site
504472001909	CoA binding site [chemical binding]; other site
504472001910	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472001911	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472001912	active site
504472001913	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472001914	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
504472001915	trimer interface [polypeptide binding]; other site
504472001916	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
504472001917	active site
504472001918	substrate binding site [chemical binding]; other site
504472001919	CoA binding site [chemical binding]; other site
504472001920	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472001921	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472001922	Bacterial sugar transferase; Region: Bac_transf; pfam02397
504472001923	tyrosine kinase; Provisional; Region: PRK11519
504472001924	Chain length determinant protein; Region: Wzz; cl15801
504472001925	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
504472001926	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472001927	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
504472001928	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472001929	Tellurite resistance protein TerB; Region: TerB; cl17311
504472001930	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472001931	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
504472001932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472001933	dimer interface [polypeptide binding]; other site
504472001934	phosphorylation site [posttranslational modification]
504472001935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472001936	ATP binding site [chemical binding]; other site
504472001937	Mg2+ binding site [ion binding]; other site
504472001938	G-X-G motif; other site
504472001939	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472001940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472001941	active site
504472001942	phosphorylation site [posttranslational modification]
504472001943	intermolecular recognition site; other site
504472001944	dimerization interface [polypeptide binding]; other site
504472001945	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472001946	DNA binding site [nucleotide binding]
504472001947	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
504472001948	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
504472001949	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
504472001950	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
504472001951	dimerization interface [polypeptide binding]; other site
504472001952	DPS ferroxidase diiron center [ion binding]; other site
504472001953	ion pore; other site
504472001954	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472001955	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472001956	Metal-binding active site; metal-binding site
504472001957	AP (apurinic/apyrimidinic) site pocket; other site
504472001958	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
504472001959	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
504472001960	5-oxoprolinase; Region: PLN02666
504472001961	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
504472001962	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
504472001963	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
504472001964	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
504472001965	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
504472001966	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
504472001967	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
504472001968	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
504472001969	dimer interface [polypeptide binding]; other site
504472001970	ADP-ribose binding site [chemical binding]; other site
504472001971	active site
504472001972	nudix motif; other site
504472001973	metal binding site [ion binding]; metal-binding site
504472001974	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472001975	putative active site [active]
504472001976	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
504472001977	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
504472001978	conserved cys residue [active]
504472001979	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472001980	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472001981	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472001982	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472001983	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472001984	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472001985	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
504472001986	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472001987	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472001988	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
504472001989	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472001990	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472001991	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472001992	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472001993	active site
504472001994	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
504472001995	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
504472001996	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472001997	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472001998	ligand binding site [chemical binding]; other site
504472001999	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472002000	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
504472002001	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472002002	YtxH-like protein; Region: YtxH; pfam12732
504472002003	YtxH-like protein; Region: YtxH; pfam12732
504472002004	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002006	active site
504472002007	phosphorylation site [posttranslational modification]
504472002008	intermolecular recognition site; other site
504472002009	dimerization interface [polypeptide binding]; other site
504472002010	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
504472002011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002012	active site
504472002013	phosphorylation site [posttranslational modification]
504472002014	intermolecular recognition site; other site
504472002015	dimerization interface [polypeptide binding]; other site
504472002016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472002017	Walker A motif; other site
504472002018	ATP binding site [chemical binding]; other site
504472002019	Walker B motif; other site
504472002020	arginine finger; other site
504472002021	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
504472002022	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472002023	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002025	active site
504472002026	phosphorylation site [posttranslational modification]
504472002027	intermolecular recognition site; other site
504472002028	dimerization interface [polypeptide binding]; other site
504472002029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002030	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472002031	active site
504472002032	phosphorylation site [posttranslational modification]
504472002033	intermolecular recognition site; other site
504472002034	dimerization interface [polypeptide binding]; other site
504472002035	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472002036	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002037	putative active site [active]
504472002038	heme pocket [chemical binding]; other site
504472002039	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002040	dimer interface [polypeptide binding]; other site
504472002041	phosphorylation site [posttranslational modification]
504472002042	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002043	ATP binding site [chemical binding]; other site
504472002044	Mg2+ binding site [ion binding]; other site
504472002045	G-X-G motif; other site
504472002046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
504472002047	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
504472002048	dimerization interface [polypeptide binding]; other site
504472002049	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
504472002050	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
504472002051	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
504472002052	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
504472002053	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
504472002054	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
504472002055	active site
504472002056	catalytic site [active]
504472002057	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
504472002058	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
504472002059	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472002060	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472002061	ligand binding site [chemical binding]; other site
504472002062	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
504472002063	Secretory lipase; Region: LIP; pfam03583
504472002064	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472002065	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472002066	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472002067	active site
504472002068	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
504472002069	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
504472002070	amidase catalytic site [active]
504472002071	Zn binding residues [ion binding]; other site
504472002072	substrate binding site [chemical binding]; other site
504472002073	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472002074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472002075	non-specific DNA binding site [nucleotide binding]; other site
504472002076	salt bridge; other site
504472002077	sequence-specific DNA binding site [nucleotide binding]; other site
504472002078	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
504472002079	Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921
504472002080	putative active site [active]
504472002081	redox center [active]
504472002082	Thioredoxin; Region: Thioredoxin_4; cl17273
504472002083	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
504472002084	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472002085	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472002086	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472002087	catalytic residues [active]
504472002088	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472002089	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472002090	catalytic residues [active]
504472002091	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
504472002092	putative active site [active]
504472002093	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
504472002094	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472002095	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472002096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472002097	Walker A/P-loop; other site
504472002098	ATP binding site [chemical binding]; other site
504472002099	Q-loop/lid; other site
504472002100	ABC transporter signature motif; other site
504472002101	Walker B; other site
504472002102	D-loop; other site
504472002103	H-loop/switch region; other site
504472002104	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
504472002105	HlyD family secretion protein; Region: HlyD; pfam00529
504472002106	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472002107	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
504472002108	Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836
504472002109	Cl binding site [ion binding]; other site
504472002110	oligomer interface [polypeptide binding]; other site
504472002111	polyadenylate binding protein, human types 1, 2, 3, 4 family; Region: PABP-1234; TIGR01628
504472002112	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
504472002113	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
504472002114	dimerization interface 3.5A [polypeptide binding]; other site
504472002115	active site
504472002116	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
504472002117	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
504472002118	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
504472002119	Bacitracin resistance protein BacA; Region: BacA; pfam02673
504472002120	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
504472002121	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
504472002122	RNA binding site [nucleotide binding]; other site
504472002123	active site
504472002124	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
504472002125	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
504472002126	active site
504472002127	Riboflavin kinase; Region: Flavokinase; pfam01687
504472002128	flavoprotein, HI0933 family; Region: TIGR00275
504472002129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472002130	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
504472002131	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
504472002132	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
504472002133	active site
504472002134	substrate binding site [chemical binding]; other site
504472002135	Mg2+ binding site [ion binding]; other site
504472002136	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002137	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472002138	FtsX-like permease family; Region: FtsX; pfam02687
504472002139	PAS domain S-box; Region: sensory_box; TIGR00229
504472002140	PAS fold; Region: PAS_4; pfam08448
504472002141	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472002142	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002143	dimer interface [polypeptide binding]; other site
504472002144	phosphorylation site [posttranslational modification]
504472002145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002146	ATP binding site [chemical binding]; other site
504472002147	Mg2+ binding site [ion binding]; other site
504472002148	G-X-G motif; other site
504472002149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002150	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002151	active site
504472002152	dimerization interface [polypeptide binding]; other site
504472002153	betaine aldehyde dehydrogenase; Region: PLN02467
504472002154	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
504472002155	tetrameric interface [polypeptide binding]; other site
504472002156	activator binding site; other site
504472002157	NADP binding site [chemical binding]; other site
504472002158	substrate binding site [chemical binding]; other site
504472002159	catalytic residues [active]
504472002160	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
504472002161	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472002162	Walker A/P-loop; other site
504472002163	ATP binding site [chemical binding]; other site
504472002164	Q-loop/lid; other site
504472002165	ABC transporter signature motif; other site
504472002166	Walker B; other site
504472002167	D-loop; other site
504472002168	H-loop/switch region; other site
504472002169	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472002170	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472002171	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472002172	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472002173	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472002174	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472002175	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
504472002176	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
504472002177	active site
504472002178	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
504472002179	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
504472002180	MoxR-like ATPases [General function prediction only]; Region: COG0714
504472002181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472002182	Walker A motif; other site
504472002183	ATP binding site [chemical binding]; other site
504472002184	Walker B motif; other site
504472002185	arginine finger; other site
504472002186	SurA N-terminal domain; Region: SurA_N; pfam09312
504472002187	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
504472002188	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
504472002189	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
504472002190	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
504472002191	OmpA family; Region: OmpA; pfam00691
504472002192	ligand binding site [chemical binding]; other site
504472002193	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
504472002194	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
504472002195	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
504472002196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472002197	motif II; other site
504472002198	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472002199	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
504472002200	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
504472002201	Ligand Binding Site [chemical binding]; other site
504472002202	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
504472002203	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
504472002204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472002205	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
504472002206	dimerization interface [polypeptide binding]; other site
504472002207	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
504472002208	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472002209	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472002210	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472002211	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472002212	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472002213	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472002214	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472002215	Predicted membrane protein [Function unknown]; Region: COG2259
504472002216	Histidine kinase; Region: His_kinase; pfam06580
504472002217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
504472002218	ATP binding site [chemical binding]; other site
504472002219	Mg2+ binding site [ion binding]; other site
504472002220	G-X-G motif; other site
504472002221	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472002222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002223	active site
504472002224	phosphorylation site [posttranslational modification]
504472002225	intermolecular recognition site; other site
504472002226	dimerization interface [polypeptide binding]; other site
504472002227	LytTr DNA-binding domain; Region: LytTR; smart00850
504472002228	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472002229	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472002230	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
504472002231	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
504472002232	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472002233	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472002234	catalytic residue [active]
504472002235	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472002236	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472002237	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
504472002238	Putative esterase; Region: Esterase; pfam00756
504472002239	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472002240	Histidine kinase; Region: His_kinase; pfam06580
504472002241	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002243	active site
504472002244	phosphorylation site [posttranslational modification]
504472002245	intermolecular recognition site; other site
504472002246	dimerization interface [polypeptide binding]; other site
504472002247	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472002248	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
504472002249	active site
504472002250	metal binding site [ion binding]; metal-binding site
504472002251	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
504472002252	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472002253	putative metal binding site [ion binding]; other site
504472002254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472002255	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472002256	putative substrate translocation pore; other site
504472002257	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
504472002258	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
504472002259	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
504472002260	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
504472002261	HTH-like domain; Region: HTH_21; pfam13276
504472002262	Integrase core domain; Region: rve; pfam00665
504472002263	Integrase core domain; Region: rve_3; pfam13683
504472002264	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472002265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
504472002266	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472002267	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472002268	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472002269	active site
504472002270	metal binding site [ion binding]; metal-binding site
504472002271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472002272	TIGR01777 family protein; Region: yfcH
504472002273	NAD(P) binding site [chemical binding]; other site
504472002274	active site
504472002275	transposase/IS protein; Provisional; Region: PRK09183
504472002276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472002277	Walker A motif; other site
504472002278	ATP binding site [chemical binding]; other site
504472002279	Walker B motif; other site
504472002280	arginine finger; other site
504472002281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472002282	Integrase core domain; Region: rve; pfam00665
504472002283	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472002284	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472002285	ligand binding site [chemical binding]; other site
504472002286	flexible hinge region; other site
504472002287	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
504472002288	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472002289	SurA N-terminal domain; Region: SurA_N; pfam09312
504472002290	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472002291	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
504472002292	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472002293	RES domain; Region: RES; pfam08808
504472002294	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472002295	peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078
504472002296	FeS/SAM binding site; other site
504472002297	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472002298	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
504472002299	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
504472002300	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472002301	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472002302	DNA binding residues [nucleotide binding]
504472002303	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472002304	FecR protein; Region: FecR; pfam04773
504472002305	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472002306	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472002307	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472002308	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472002309	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472002310	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472002311	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472002312	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472002313	Metal-binding active site; metal-binding site
504472002314	RES domain; Region: RES; pfam08808
504472002315	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472002316	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472002317	RES domain; Region: RES; cl02411
504472002318	RES domain; Region: RES; smart00953
504472002319	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472002320	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472002321	DinB superfamily; Region: DinB_2; pfam12867
504472002322	Uncharacterized conserved protein [Function unknown]; Region: COG2353
504472002323	Pirin-related protein [General function prediction only]; Region: COG1741
504472002324	Pirin; Region: Pirin; pfam02678
504472002325	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
504472002326	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472002327	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472002328	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472002329	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472002330	short chain dehydrogenase; Provisional; Region: PRK06523
504472002331	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472002332	NAD(P) binding site [chemical binding]; other site
504472002333	active site
504472002334	Helix-turn-helix domain; Region: HTH_28; pfam13518
504472002335	Winged helix-turn helix; Region: HTH_29; pfam13551
504472002336	Homeodomain-like domain; Region: HTH_32; pfam13565
504472002337	Integrase core domain; Region: rve; pfam00665
504472002338	Integrase core domain; Region: rve_3; pfam13683
504472002339	Transposase; Region: HTH_Tnp_1; pfam01527
504472002340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
504472002341	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
504472002342	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
504472002343	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
504472002344	putative active site [active]
504472002345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472002346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472002347	Walker A/P-loop; other site
504472002348	ATP binding site [chemical binding]; other site
504472002349	Q-loop/lid; other site
504472002350	ABC transporter signature motif; other site
504472002351	Walker B; other site
504472002352	D-loop; other site
504472002353	H-loop/switch region; other site
504472002354	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472002355	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
504472002356	active site
504472002357	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
504472002358	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
504472002359	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
504472002360	putative active site [active]
504472002361	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
504472002362	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472002363	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472002364	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472002365	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472002366	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
504472002367	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472002368	FeS/SAM binding site; other site
504472002369	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
504472002370	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
504472002371	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
504472002372	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472002373	FeS/SAM binding site; other site
504472002374	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
504472002375	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
504472002376	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
504472002377	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472002378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002379	active site
504472002380	phosphorylation site [posttranslational modification]
504472002381	intermolecular recognition site; other site
504472002382	dimerization interface [polypeptide binding]; other site
504472002383	LytTr DNA-binding domain; Region: LytTR; smart00850
504472002384	Histidine kinase; Region: His_kinase; pfam06580
504472002385	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
504472002386	Homeodomain-like domain; Region: HTH_23; pfam13384
504472002387	Winged helix-turn helix; Region: HTH_29; pfam13551
504472002388	Homeodomain-like domain; Region: HTH_32; pfam13565
504472002389	Winged helix-turn helix; Region: HTH_33; pfam13592
504472002390	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472002391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472002392	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
504472002393	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472002394	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
504472002395	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472002396	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472002397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002398	active site
504472002399	phosphorylation site [posttranslational modification]
504472002400	intermolecular recognition site; other site
504472002401	dimerization interface [polypeptide binding]; other site
504472002402	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472002403	DNA binding site [nucleotide binding]
504472002404	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472002405	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472002406	dimerization interface [polypeptide binding]; other site
504472002407	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002408	dimer interface [polypeptide binding]; other site
504472002409	phosphorylation site [posttranslational modification]
504472002410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002411	ATP binding site [chemical binding]; other site
504472002412	Mg2+ binding site [ion binding]; other site
504472002413	G-X-G motif; other site
504472002414	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472002415	Two component regulator propeller; Region: Reg_prop; pfam07494
504472002416	Two component regulator propeller; Region: Reg_prop; pfam07494
504472002417	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472002418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472002419	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002420	dimer interface [polypeptide binding]; other site
504472002421	phosphorylation site [posttranslational modification]
504472002422	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002423	ATP binding site [chemical binding]; other site
504472002424	G-X-G motif; other site
504472002425	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
504472002426	AAA domain; Region: AAA_14; pfam13173
504472002427	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
504472002428	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472002429	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472002430	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002431	FtsX-like permease family; Region: FtsX; pfam02687
504472002432	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002433	FtsX-like permease family; Region: FtsX; pfam02687
504472002434	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
504472002435	active site
504472002436	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002437	FtsX-like permease family; Region: FtsX; pfam02687
504472002438	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002439	FtsX-like permease family; Region: FtsX; pfam02687
504472002440	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472002441	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002442	FtsX-like permease family; Region: FtsX; pfam02687
504472002443	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002444	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472002445	FtsX-like permease family; Region: FtsX; pfam02687
504472002446	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002447	FtsX-like permease family; Region: FtsX; pfam02687
504472002448	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472002449	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002450	FtsX-like permease family; Region: FtsX; pfam02687
504472002451	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002452	FtsX-like permease family; Region: FtsX; pfam02687
504472002453	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002454	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472002455	FtsX-like permease family; Region: FtsX; pfam02687
504472002456	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002457	FtsX-like permease family; Region: FtsX; pfam02687
504472002458	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472002459	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472002460	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
504472002461	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
504472002462	active site
504472002463	Zn binding site [ion binding]; other site
504472002464	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472002465	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002466	FtsX-like permease family; Region: FtsX; pfam02687
504472002467	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002468	FtsX-like permease family; Region: FtsX; pfam02687
504472002469	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002470	FtsX-like permease family; Region: FtsX; pfam02687
504472002471	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002472	FtsX-like permease family; Region: FtsX; pfam02687
504472002473	Cupin domain; Region: Cupin_2; cl17218
504472002474	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472002475	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472002476	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472002477	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002478	FtsX-like permease family; Region: FtsX; pfam02687
504472002479	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472002480	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472002481	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472002482	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472002483	DoxX-like family; Region: DoxX_2; pfam13564
504472002484	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002485	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002486	FtsX-like permease family; Region: FtsX; pfam02687
504472002487	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002488	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472002489	FtsX-like permease family; Region: FtsX; pfam02687
504472002490	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472002491	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002492	FtsX-like permease family; Region: FtsX; pfam02687
504472002493	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472002494	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472002495	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472002496	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002497	FtsX-like permease family; Region: FtsX; pfam02687
504472002498	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002499	FtsX-like permease family; Region: FtsX; pfam02687
504472002500	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002501	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472002502	FtsX-like permease family; Region: FtsX; pfam02687
504472002503	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472002504	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002505	FtsX-like permease family; Region: FtsX; pfam02687
504472002506	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472002507	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002508	FtsX-like permease family; Region: FtsX; pfam02687
504472002509	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002510	FtsX-like permease family; Region: FtsX; pfam02687
504472002511	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472002512	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472002513	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472002514	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472002515	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
504472002516	phosphate binding site [ion binding]; other site
504472002517	PspC domain; Region: PspC; pfam04024
504472002518	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472002519	DNA-binding site [nucleotide binding]; DNA binding site
504472002520	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
504472002521	putative ligand binding site [chemical binding]; other site
504472002522	putative dimerization interface [polypeptide binding]; other site
504472002523	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472002524	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472002525	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472002526	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472002527	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472002528	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472002529	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472002530	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
504472002531	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472002532	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
504472002533	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
504472002534	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472002535	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472002536	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
504472002537	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
504472002538	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472002539	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
504472002540	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472002541	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
504472002542	Fn3 associated; Region: Fn3_assoc; pfam13287
504472002543	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472002544	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472002545	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472002546	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472002547	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472002548	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472002549	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
504472002550	Cytochrome c; Region: Cytochrom_C; pfam00034
504472002551	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472002552	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
504472002553	active site
504472002554	catalytic residues [active]
504472002555	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
504472002556	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472002557	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472002558	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472002559	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472002560	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240
504472002561	putative active site [active]
504472002562	Zn binding site [ion binding]; other site
504472002563	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472002564	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472002565	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472002566	DNA binding residues [nucleotide binding]
504472002567	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
504472002568	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
504472002569	PYR/PP interface [polypeptide binding]; other site
504472002570	dimer interface [polypeptide binding]; other site
504472002571	TPP binding site [chemical binding]; other site
504472002572	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
504472002573	transketolase; Reviewed; Region: PRK05899
504472002574	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
504472002575	TPP-binding site [chemical binding]; other site
504472002576	dimer interface [polypeptide binding]; other site
504472002577	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
504472002578	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
504472002579	catalytic triad [active]
504472002580	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
504472002581	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472002582	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
504472002583	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
504472002584	Peptidase family M48; Region: Peptidase_M48; pfam01435
504472002585	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
504472002586	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
504472002587	CoA-ligase; Region: Ligase_CoA; pfam00549
504472002588	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472002589	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472002590	Walker A/P-loop; other site
504472002591	ATP binding site [chemical binding]; other site
504472002592	Q-loop/lid; other site
504472002593	ABC transporter signature motif; other site
504472002594	Walker B; other site
504472002595	D-loop; other site
504472002596	H-loop/switch region; other site
504472002597	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
504472002598	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
504472002599	ring oligomerisation interface [polypeptide binding]; other site
504472002600	ATP/Mg binding site [chemical binding]; other site
504472002601	stacking interactions; other site
504472002602	hinge regions; other site
504472002603	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
504472002604	oligomerisation interface [polypeptide binding]; other site
504472002605	mobile loop; other site
504472002606	roof hairpin; other site
504472002607	Preprotein translocase SecG subunit; Region: SecG; pfam03840
504472002608	Lipopolysaccharide-assembly; Region: LptE; cl01125
504472002609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472002610	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472002611	Walker A motif; other site
504472002612	ATP binding site [chemical binding]; other site
504472002613	Walker B motif; other site
504472002614	arginine finger; other site
504472002615	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
504472002616	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
504472002617	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
504472002618	TRAM domain; Region: TRAM; pfam01938
504472002619	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472002620	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
504472002621	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
504472002622	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
504472002623	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
504472002624	Ribosome-binding factor A; Region: RBFA; pfam02033
504472002625	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
504472002626	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472002627	FtsX-like permease family; Region: FtsX; pfam02687
504472002628	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
504472002629	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
504472002630	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
504472002631	Zn binding site [ion binding]; other site
504472002632	toxin interface [polypeptide binding]; other site
504472002633	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
504472002634	L-fucose transporter; Provisional; Region: PRK10133; cl17665
504472002635	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472002636	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472002637	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
504472002638	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
504472002639	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
504472002640	active site
504472002641	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
504472002642	GTP cyclohydrolase I; Provisional; Region: PLN03044
504472002643	active site
504472002644	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
504472002645	classical (c) SDRs; Region: SDR_c; cd05233
504472002646	NAD(P) binding site [chemical binding]; other site
504472002647	active site
504472002648	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
504472002649	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
504472002650	dimer interface [polypeptide binding]; other site
504472002651	NADP binding site [chemical binding]; other site
504472002652	catalytic residues [active]
504472002653	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472002654	serine racemase; Region: PLN02970
504472002655	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
504472002656	tetramer interface [polypeptide binding]; other site
504472002657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472002658	catalytic residue [active]
504472002659	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
504472002660	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
504472002661	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
504472002662	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472002663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472002664	Coenzyme A binding pocket [chemical binding]; other site
504472002665	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472002666	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472002667	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472002668	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472002669	DNA binding residues [nucleotide binding]
504472002670	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
504472002671	oxyanion hole [active]
504472002672	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
504472002673	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472002674	Protein export membrane protein; Region: SecD_SecF; cl14618
504472002675	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472002676	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472002677	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472002678	E3 interaction surface; other site
504472002679	lipoyl attachment site [posttranslational modification]; other site
504472002680	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472002681	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
504472002682	putative active site [active]
504472002683	putative CoA binding site [chemical binding]; other site
504472002684	nudix motif; other site
504472002685	metal binding site [ion binding]; metal-binding site
504472002686	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
504472002687	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
504472002688	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
504472002689	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
504472002690	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472002691	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472002692	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
504472002693	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
504472002694	active site
504472002695	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472002696	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472002697	active site
504472002698	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002700	active site
504472002701	phosphorylation site [posttranslational modification]
504472002702	intermolecular recognition site; other site
504472002703	dimerization interface [polypeptide binding]; other site
504472002704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002705	active site
504472002706	phosphorylation site [posttranslational modification]
504472002707	intermolecular recognition site; other site
504472002708	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472002709	dimerization interface [polypeptide binding]; other site
504472002710	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002711	dimer interface [polypeptide binding]; other site
504472002712	phosphorylation site [posttranslational modification]
504472002713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002714	ATP binding site [chemical binding]; other site
504472002715	Mg2+ binding site [ion binding]; other site
504472002716	G-X-G motif; other site
504472002717	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
504472002718	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
504472002719	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
504472002720	GAF domain; Region: GAF_2; pfam13185
504472002721	GAF domain; Region: GAF_3; pfam13492
504472002722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002723	dimer interface [polypeptide binding]; other site
504472002724	phosphorylation site [posttranslational modification]
504472002725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002726	ATP binding site [chemical binding]; other site
504472002727	Mg2+ binding site [ion binding]; other site
504472002728	G-X-G motif; other site
504472002729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002730	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002731	active site
504472002732	phosphorylation site [posttranslational modification]
504472002733	intermolecular recognition site; other site
504472002734	dimerization interface [polypeptide binding]; other site
504472002735	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002737	active site
504472002738	phosphorylation site [posttranslational modification]
504472002739	intermolecular recognition site; other site
504472002740	dimerization interface [polypeptide binding]; other site
504472002741	CheB methylesterase; Region: CheB_methylest; pfam01339
504472002742	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
504472002743	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
504472002744	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002746	active site
504472002747	phosphorylation site [posttranslational modification]
504472002748	intermolecular recognition site; other site
504472002749	dimerization interface [polypeptide binding]; other site
504472002750	CHASE3 domain; Region: CHASE3; pfam05227
504472002751	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472002752	dimerization interface [polypeptide binding]; other site
504472002753	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472002754	GAF domain; Region: GAF_3; pfam13492
504472002755	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
504472002756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002757	ATP binding site [chemical binding]; other site
504472002758	Mg2+ binding site [ion binding]; other site
504472002759	G-X-G motif; other site
504472002760	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472002761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002762	active site
504472002763	phosphorylation site [posttranslational modification]
504472002764	intermolecular recognition site; other site
504472002765	dimerization interface [polypeptide binding]; other site
504472002766	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472002767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002768	active site
504472002769	phosphorylation site [posttranslational modification]
504472002770	intermolecular recognition site; other site
504472002771	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002773	active site
504472002774	phosphorylation site [posttranslational modification]
504472002775	intermolecular recognition site; other site
504472002776	dimerization interface [polypeptide binding]; other site
504472002777	Response regulator receiver domain; Region: Response_reg; pfam00072
504472002778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002779	active site
504472002780	phosphorylation site [posttranslational modification]
504472002781	intermolecular recognition site; other site
504472002782	dimerization interface [polypeptide binding]; other site
504472002783	PAS fold; Region: PAS_4; pfam08448
504472002784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002785	dimer interface [polypeptide binding]; other site
504472002786	phosphorylation site [posttranslational modification]
504472002787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002788	ATP binding site [chemical binding]; other site
504472002789	Mg2+ binding site [ion binding]; other site
504472002790	G-X-G motif; other site
504472002791	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472002792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002793	active site
504472002794	phosphorylation site [posttranslational modification]
504472002795	intermolecular recognition site; other site
504472002796	dimerization interface [polypeptide binding]; other site
504472002797	LytTr DNA-binding domain; Region: LytTR; smart00850
504472002798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
504472002799	PAS domain; Region: PAS_9; pfam13426
504472002800	putative active site [active]
504472002801	heme pocket [chemical binding]; other site
504472002802	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472002803	GAF domain; Region: GAF_3; pfam13492
504472002804	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472002805	GAF domain; Region: GAF; pfam01590
504472002806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002807	PAS domain; Region: PAS_9; pfam13426
504472002808	putative active site [active]
504472002809	heme pocket [chemical binding]; other site
504472002810	PAS domain S-box; Region: sensory_box; TIGR00229
504472002811	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002812	putative active site [active]
504472002813	heme pocket [chemical binding]; other site
504472002814	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472002815	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472002816	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472002817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002818	dimer interface [polypeptide binding]; other site
504472002819	phosphorylation site [posttranslational modification]
504472002820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002821	ATP binding site [chemical binding]; other site
504472002822	Mg2+ binding site [ion binding]; other site
504472002823	G-X-G motif; other site
504472002824	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472002825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472002826	active site
504472002827	phosphorylation site [posttranslational modification]
504472002828	intermolecular recognition site; other site
504472002829	dimerization interface [polypeptide binding]; other site
504472002830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
504472002831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002832	ATP binding site [chemical binding]; other site
504472002833	Mg2+ binding site [ion binding]; other site
504472002834	G-X-G motif; other site
504472002835	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472002836	GAF domain; Region: GAF; pfam01590
504472002837	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472002838	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
504472002839	PAS domain S-box; Region: sensory_box; TIGR00229
504472002840	PAS domain S-box; Region: sensory_box; TIGR00229
504472002841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002842	putative active site [active]
504472002843	heme pocket [chemical binding]; other site
504472002844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002845	PAS fold; Region: PAS_3; pfam08447
504472002846	putative active site [active]
504472002847	heme pocket [chemical binding]; other site
504472002848	PAS domain S-box; Region: sensory_box; TIGR00229
504472002849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002850	putative active site [active]
504472002851	heme pocket [chemical binding]; other site
504472002852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472002853	putative active site [active]
504472002854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472002855	heme pocket [chemical binding]; other site
504472002856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472002857	dimer interface [polypeptide binding]; other site
504472002858	phosphorylation site [posttranslational modification]
504472002859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472002860	ATP binding site [chemical binding]; other site
504472002861	Mg2+ binding site [ion binding]; other site
504472002862	G-X-G motif; other site
504472002863	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472002864	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472002865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472002866	Walker A/P-loop; other site
504472002867	ATP binding site [chemical binding]; other site
504472002868	Q-loop/lid; other site
504472002869	ABC transporter signature motif; other site
504472002870	Walker B; other site
504472002871	D-loop; other site
504472002872	H-loop/switch region; other site
504472002873	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
504472002874	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472002875	Sulfatase; Region: Sulfatase; cl17466
504472002876	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472002877	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
504472002878	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472002879	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
504472002880	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
504472002881	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
504472002882	putative ligand binding site [chemical binding]; other site
504472002883	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
504472002884	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
504472002885	TM-ABC transporter signature motif; other site
504472002886	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
504472002887	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
504472002888	Walker A/P-loop; other site
504472002889	ATP binding site [chemical binding]; other site
504472002890	Q-loop/lid; other site
504472002891	ABC transporter signature motif; other site
504472002892	Walker B; other site
504472002893	D-loop; other site
504472002894	H-loop/switch region; other site
504472002895	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
504472002896	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
504472002897	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
504472002898	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
504472002899	folate binding site [chemical binding]; other site
504472002900	NADP+ binding site [chemical binding]; other site
504472002901	Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802
504472002902	putative active site [active]
504472002903	YdjC motif; other site
504472002904	Mg binding site [ion binding]; other site
504472002905	homodimer interface [polypeptide binding]; other site
504472002906	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
504472002907	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
504472002908	putative active site [active]
504472002909	substrate binding site [chemical binding]; other site
504472002910	putative cosubstrate binding site; other site
504472002911	catalytic site [active]
504472002912	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
504472002913	substrate binding site [chemical binding]; other site
504472002914	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
504472002915	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
504472002916	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
504472002917	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
504472002918	nucleotide binding site/active site [active]
504472002919	HIT family signature motif; other site
504472002920	catalytic residue [active]
504472002921	altronate oxidoreductase; Provisional; Region: PRK03643
504472002922	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
504472002923	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
504472002924	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472002925	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
504472002926	substrate binding site [chemical binding]; other site
504472002927	ATP binding site [chemical binding]; other site
504472002928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472002929	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472002930	putative substrate translocation pore; other site
504472002931	mannonate dehydratase; Region: uxuA; TIGR00695
504472002932	mannonate dehydratase; Provisional; Region: PRK03906
504472002933	Glucuronate isomerase; Region: UxaC; pfam02614
504472002934	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
504472002935	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472002936	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472002937	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472002938	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472002939	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
504472002940	active site
504472002941	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
504472002942	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
504472002943	active site
504472002944	Zn binding site [ion binding]; other site
504472002945	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
504472002946	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
504472002947	DinB superfamily; Region: DinB_2; pfam12867
504472002948	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
504472002949	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
504472002950	metal binding site [ion binding]; metal-binding site
504472002951	substrate binding pocket [chemical binding]; other site
504472002952	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
504472002953	mannonate dehydratase; Region: uxuA; TIGR00695
504472002954	fructuronate transporter; Provisional; Region: PRK10034; cl15264
504472002955	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
504472002956	fructuronate transporter; Provisional; Region: PRK10034; cl15264
504472002957	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
504472002958	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
504472002959	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472002960	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472002961	catalytic residue [active]
504472002962	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
504472002963	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472002964	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
504472002965	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
504472002966	ligand binding site [chemical binding]; other site
504472002967	NAD binding site [chemical binding]; other site
504472002968	tetramer interface [polypeptide binding]; other site
504472002969	catalytic site [active]
504472002970	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
504472002971	L-serine binding site [chemical binding]; other site
504472002972	ACT domain interface; other site
504472002973	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
504472002974	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
504472002975	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
504472002976	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
504472002977	active site
504472002978	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
504472002979	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472002980	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472002981	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
504472002982	NADP binding site [chemical binding]; other site
504472002983	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472002984	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472002985	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472002986	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
504472002987	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
504472002988	oligomerisation interface [polypeptide binding]; other site
504472002989	mobile loop; other site
504472002990	roof hairpin; other site
504472002991	Haemolytic domain; Region: Haemolytic; pfam01809
504472002992	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
504472002993	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
504472002994	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472002995	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472002996	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
504472002997	Peptidase family M1; Region: Peptidase_M1; pfam01433
504472002998	Zn binding site [ion binding]; other site
504472002999	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
504472003000	catalytic triad [active]
504472003001	putative active site [active]
504472003002	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472003003	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
504472003004	substrate binding site [chemical binding]; other site
504472003005	ATP binding site [chemical binding]; other site
504472003006	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
504472003007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472003008	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472003009	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
504472003010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
504472003011	SPFH domain / Band 7 family; Region: Band_7; pfam01145
504472003012	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472003013	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472003014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472003015	Walker A/P-loop; other site
504472003016	ATP binding site [chemical binding]; other site
504472003017	Q-loop/lid; other site
504472003018	ABC transporter signature motif; other site
504472003019	Walker B; other site
504472003020	D-loop; other site
504472003021	H-loop/switch region; other site
504472003022	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472003023	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472003024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472003025	Walker A/P-loop; other site
504472003026	ATP binding site [chemical binding]; other site
504472003027	Q-loop/lid; other site
504472003028	ABC transporter signature motif; other site
504472003029	Walker B; other site
504472003030	D-loop; other site
504472003031	H-loop/switch region; other site
504472003032	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472003033	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472003034	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
504472003035	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
504472003036	homodimer interface [polypeptide binding]; other site
504472003037	substrate-cofactor binding pocket; other site
504472003038	catalytic residue [active]
504472003039	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
504472003040	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
504472003041	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
504472003042	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
504472003043	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
504472003044	active site
504472003045	HIGH motif; other site
504472003046	dimer interface [polypeptide binding]; other site
504472003047	KMSKS motif; other site
504472003048	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
504472003049	RNA binding surface [nucleotide binding]; other site
504472003050	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
504472003051	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472003052	catalytic loop [active]
504472003053	iron binding site [ion binding]; other site
504472003054	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472003055	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472003056	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472003057	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472003058	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472003059	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
504472003060	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
504472003061	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
504472003062	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
504472003063	putative catalytic site [active]
504472003064	putative metal binding site [ion binding]; other site
504472003065	putative phosphate binding site [ion binding]; other site
504472003066	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472003067	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472003068	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
504472003069	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472003070	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472003071	NifU-like domain; Region: NifU; cl00484
504472003072	antiporter inner membrane protein; Provisional; Region: PRK11670
504472003073	Domain of unknown function DUF59; Region: DUF59; pfam01883
504472003074	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
504472003075	Walker A motif; other site
504472003076	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472003077	catalytic triad [active]
504472003078	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
504472003079	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
504472003080	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
504472003081	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
504472003082	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
504472003083	Protein of unknown function (DUF904); Region: DUF904; pfam06005
504472003084	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
504472003085	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
504472003086	catalytic residue [active]
504472003087	Protein of unknown function (DUF423); Region: DUF423; pfam04241
504472003088	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
504472003089	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
504472003090	G1 box; other site
504472003091	putative GEF interaction site [polypeptide binding]; other site
504472003092	GTP/Mg2+ binding site [chemical binding]; other site
504472003093	Switch I region; other site
504472003094	G2 box; other site
504472003095	G3 box; other site
504472003096	Switch II region; other site
504472003097	G4 box; other site
504472003098	G5 box; other site
504472003099	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
504472003100	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
504472003101	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
504472003102	Walker A/P-loop; other site
504472003103	ATP binding site [chemical binding]; other site
504472003104	Q-loop/lid; other site
504472003105	ABC transporter signature motif; other site
504472003106	Walker B; other site
504472003107	D-loop; other site
504472003108	H-loop/switch region; other site
504472003109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472003110	DNA-binding site [nucleotide binding]; DNA binding site
504472003111	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
504472003112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
504472003113	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
504472003114	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472003115	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
504472003116	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
504472003117	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
504472003118	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
504472003119	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472003120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472003121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472003122	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472003123	active site
504472003124	phosphorylation site [posttranslational modification]
504472003125	intermolecular recognition site; other site
504472003126	dimerization interface [polypeptide binding]; other site
504472003127	Right handed beta helix region; Region: Beta_helix; pfam13229
504472003128	Right handed beta helix region; Region: Beta_helix; pfam13229
504472003129	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
504472003130	protein binding site [polypeptide binding]; other site
504472003131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472003132	NAD(P) binding site [chemical binding]; other site
504472003133	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472003134	active site
504472003135	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
504472003136	Trp docking motif [polypeptide binding]; other site
504472003137	putative active site [active]
504472003138	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472003139	Cytochrome c; Region: Cytochrom_C; pfam00034
504472003140	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472003141	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
504472003142	dimer interface [polypeptide binding]; other site
504472003143	catalytic triad [active]
504472003144	peroxidatic and resolving cysteines [active]
504472003145	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
504472003146	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
504472003147	intersubunit interface [polypeptide binding]; other site
504472003148	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
504472003149	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003150	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472003151	YcfA-like protein; Region: YcfA; pfam07927
504472003152	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
504472003153	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
504472003154	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
504472003155	oligomer interface [polypeptide binding]; other site
504472003156	active site
504472003157	metal binding site [ion binding]; metal-binding site
504472003158	Predicted ATPases [General function prediction only]; Region: COG1106
504472003159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472003160	Walker A/P-loop; other site
504472003161	ATP binding site [chemical binding]; other site
504472003162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472003163	non-specific DNA binding site [nucleotide binding]; other site
504472003164	salt bridge; other site
504472003165	sequence-specific DNA binding site [nucleotide binding]; other site
504472003166	Clp protease; Region: CLP_protease; pfam00574
504472003167	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
504472003168	oligomer interface [polypeptide binding]; other site
504472003169	active site residues [active]
504472003170	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003171	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472003172	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472003173	non-specific DNA binding site [nucleotide binding]; other site
504472003174	salt bridge; other site
504472003175	sequence-specific DNA binding site [nucleotide binding]; other site
504472003176	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
504472003177	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
504472003178	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
504472003179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472003180	Walker A motif; other site
504472003181	ATP binding site [chemical binding]; other site
504472003182	Walker B motif; other site
504472003183	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
504472003184	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472003185	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
504472003186	acetylornithine aminotransferase; Provisional; Region: PRK02627
504472003187	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
504472003188	inhibitor-cofactor binding pocket; inhibition site
504472003189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472003190	catalytic residue [active]
504472003191	Protein of unknown function (DUF433); Region: DUF433; pfam04255
504472003192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
504472003193	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
504472003194	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
504472003195	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
504472003196	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
504472003197	nucleotide binding site [chemical binding]; other site
504472003198	N-acetyl-L-glutamate binding site [chemical binding]; other site
504472003199	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
504472003200	NlpC/P60 family; Region: NLPC_P60; pfam00877
504472003201	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
504472003202	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
504472003203	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
504472003204	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472003205	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472003206	active site
504472003207	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
504472003208	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472003209	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472003210	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472003211	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003212	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472003213	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472003214	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472003215	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472003216	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003217	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472003218	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472003219	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472003220	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472003221	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472003222	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
504472003223	membrane ATPase/protein kinase; Provisional; Region: PRK09435
504472003224	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
504472003225	Walker A; other site
504472003226	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
504472003227	substrate binding site; other site
504472003228	dimer interface; other site
504472003229	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
504472003230	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
504472003231	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472003232	PAS fold; Region: PAS_4; pfam08448
504472003233	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472003234	putative active site [active]
504472003235	heme pocket [chemical binding]; other site
504472003236	PAS fold; Region: PAS_4; pfam08448
504472003237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472003238	putative active site [active]
504472003239	heme pocket [chemical binding]; other site
504472003240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472003241	dimer interface [polypeptide binding]; other site
504472003242	phosphorylation site [posttranslational modification]
504472003243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472003244	ATP binding site [chemical binding]; other site
504472003245	Mg2+ binding site [ion binding]; other site
504472003246	G-X-G motif; other site
504472003247	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
504472003248	NHAD transporter family protein; Provisional; Region: PLN00137
504472003249	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472003250	putative DNA binding site [nucleotide binding]; other site
504472003251	dimerization interface [polypeptide binding]; other site
504472003252	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472003253	putative Zn2+ binding site [ion binding]; other site
504472003254	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
504472003255	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
504472003256	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
504472003257	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472003258	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472003259	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
504472003260	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
504472003261	homodimer interface [polypeptide binding]; other site
504472003262	metal binding site [ion binding]; metal-binding site
504472003263	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
504472003264	homodimer interface [polypeptide binding]; other site
504472003265	active site
504472003266	putative chemical substrate binding site [chemical binding]; other site
504472003267	metal binding site [ion binding]; metal-binding site
504472003268	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
504472003269	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472003270	active site
504472003271	metal binding site [ion binding]; metal-binding site
504472003272	hexamer interface [polypeptide binding]; other site
504472003273	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
504472003274	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
504472003275	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
504472003276	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
504472003277	active site
504472003278	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
504472003279	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
504472003280	DHH family; Region: DHH; pfam01368
504472003281	DHHA1 domain; Region: DHHA1; pfam02272
504472003282	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
504472003283	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
504472003284	Walker A/P-loop; other site
504472003285	ATP binding site [chemical binding]; other site
504472003286	Q-loop/lid; other site
504472003287	ABC transporter signature motif; other site
504472003288	Walker B; other site
504472003289	D-loop; other site
504472003290	H-loop/switch region; other site
504472003291	Recombination protein O N terminal; Region: RecO_N; pfam11967
504472003292	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
504472003293	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
504472003294	ATP-grasp domain; Region: ATP-grasp; pfam02222
504472003295	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
504472003296	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472003297	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472003298	Walker A/P-loop; other site
504472003299	ATP binding site [chemical binding]; other site
504472003300	Q-loop/lid; other site
504472003301	ABC transporter signature motif; other site
504472003302	Walker B; other site
504472003303	D-loop; other site
504472003304	H-loop/switch region; other site
504472003305	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
504472003306	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
504472003307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472003308	catalytic residue [active]
504472003309	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472003310	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472003311	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472003312	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472003313	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
504472003314	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
504472003315	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
504472003316	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472003317	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472003318	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
504472003319	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
504472003320	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
504472003321	putative catalytic site [active]
504472003322	putative metal binding site [ion binding]; other site
504472003323	putative phosphate binding site [ion binding]; other site
504472003324	Sm and related proteins; Region: Sm_like; cl00259
504472003325	ribosome maturation protein RimP; Reviewed; Region: PRK00092
504472003326	heptamer interface [polypeptide binding]; other site
504472003327	Sm1 motif; other site
504472003328	hexamer interface [polypeptide binding]; other site
504472003329	RNA binding site [nucleotide binding]; other site
504472003330	Sm2 motif; other site
504472003331	transcription termination factor NusA; Region: NusA; TIGR01953
504472003332	NusA N-terminal domain; Region: NusA_N; pfam08529
504472003333	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
504472003334	RNA binding site [nucleotide binding]; other site
504472003335	homodimer interface [polypeptide binding]; other site
504472003336	NusA-like KH domain; Region: KH_5; pfam13184
504472003337	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
504472003338	G-X-X-G motif; other site
504472003339	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
504472003340	translation initiation factor IF-2; Region: IF-2; TIGR00487
504472003341	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
504472003342	G1 box; other site
504472003343	putative GEF interaction site [polypeptide binding]; other site
504472003344	GTP/Mg2+ binding site [chemical binding]; other site
504472003345	Switch I region; other site
504472003346	G2 box; other site
504472003347	G3 box; other site
504472003348	Switch II region; other site
504472003349	G4 box; other site
504472003350	G5 box; other site
504472003351	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
504472003352	Translation-initiation factor 2; Region: IF-2; pfam11987
504472003353	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
504472003354	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472003355	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472003356	active site
504472003357	metal binding site [ion binding]; metal-binding site
504472003358	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
504472003359	CARDB; Region: CARDB; pfam07705
504472003360	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472003361	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472003362	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472003363	DNA binding residues [nucleotide binding]
504472003364	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472003365	FecR protein; Region: FecR; pfam04773
504472003366	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472003367	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003368	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472003369	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472003370	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472003371	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472003372	SusD family; Region: SusD; pfam07980
504472003373	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
504472003374	active site
504472003375	catalytic triad [active]
504472003376	oxyanion hole [active]
504472003377	MG2 domain; Region: A2M_N; pfam01835
504472003378	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472003379	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003380	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472003381	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472003382	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472003383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472003384	active site
504472003385	phosphorylation site [posttranslational modification]
504472003386	intermolecular recognition site; other site
504472003387	dimerization interface [polypeptide binding]; other site
504472003388	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472003389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472003390	dimer interface [polypeptide binding]; other site
504472003391	phosphorylation site [posttranslational modification]
504472003392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472003393	ATP binding site [chemical binding]; other site
504472003394	Mg2+ binding site [ion binding]; other site
504472003395	G-X-G motif; other site
504472003396	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
504472003397	active site
504472003398	catalytic triad [active]
504472003399	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
504472003400	homotrimer interaction site [polypeptide binding]; other site
504472003401	putative active site [active]
504472003402	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821
504472003403	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
504472003404	dimer interface [polypeptide binding]; other site
504472003405	active site
504472003406	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
504472003407	substrate binding site [chemical binding]; other site
504472003408	catalytic residue [active]
504472003409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472003410	S-adenosylmethionine binding site [chemical binding]; other site
504472003411	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
504472003412	active site
504472003413	catalytic residues [active]
504472003414	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
504472003415	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
504472003416	intersubunit interface [polypeptide binding]; other site
504472003417	active site
504472003418	Zn2+ binding site [ion binding]; other site
504472003419	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
504472003420	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
504472003421	L-arabinose isomerase; Provisional; Region: PRK02929
504472003422	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
504472003423	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
504472003424	trimer interface [polypeptide binding]; other site
504472003425	putative substrate binding site [chemical binding]; other site
504472003426	putative metal binding site [ion binding]; other site
504472003427	ribulokinase; Provisional; Region: PRK04123
504472003428	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
504472003429	N- and C-terminal domain interface [polypeptide binding]; other site
504472003430	active site
504472003431	MgATP binding site [chemical binding]; other site
504472003432	catalytic site [active]
504472003433	metal binding site [ion binding]; metal-binding site
504472003434	carbohydrate binding site [chemical binding]; other site
504472003435	homodimer interface [polypeptide binding]; other site
504472003436	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
504472003437	nudix motif; other site
504472003438	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
504472003439	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
504472003440	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472003441	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
504472003442	active site
504472003443	catalytic triad [active]
504472003444	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
504472003445	AMP binding site [chemical binding]; other site
504472003446	metal binding site [ion binding]; metal-binding site
504472003447	active site
504472003448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472003449	D-galactonate transporter; Region: 2A0114; TIGR00893
504472003450	putative substrate translocation pore; other site
504472003451	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
504472003452	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
504472003453	active site
504472003454	intersubunit interface [polypeptide binding]; other site
504472003455	catalytic residue [active]
504472003456	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
504472003457	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472003458	substrate binding site [chemical binding]; other site
504472003459	ATP binding site [chemical binding]; other site
504472003460	altronate oxidoreductase; Provisional; Region: PRK03643
504472003461	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
504472003462	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
504472003463	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472003464	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472003465	DNA binding site [nucleotide binding]
504472003466	domain linker motif; other site
504472003467	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472003468	dimerization interface [polypeptide binding]; other site
504472003469	ligand binding site [chemical binding]; other site
504472003470	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
504472003471	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
504472003472	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472003473	Sulfatase; Region: Sulfatase; cl17466
504472003474	Sulfatase; Region: Sulfatase; cl17466
504472003475	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472003476	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
504472003477	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
504472003478	active site
504472003479	metal binding site [ion binding]; metal-binding site
504472003480	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
504472003481	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
504472003482	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
504472003483	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003484	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003485	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003486	Putative esterase; Region: Esterase; pfam00756
504472003487	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
504472003488	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003489	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003490	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472003491	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472003492	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
504472003493	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
504472003494	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
504472003495	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
504472003496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472003497	putative substrate translocation pore; other site
504472003498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472003499	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472003500	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
504472003501	putative NAD(P) binding site [chemical binding]; other site
504472003502	catalytic Zn binding site [ion binding]; other site
504472003503	structural Zn binding site [ion binding]; other site
504472003504	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
504472003505	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
504472003506	active site
504472003507	catalytic triad [active]
504472003508	oxyanion hole [active]
504472003509	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472003510	HEAT repeats; Region: HEAT_2; pfam13646
504472003511	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472003512	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472003513	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472003514	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472003515	DNA interaction; other site
504472003516	Metal-binding active site; metal-binding site
504472003517	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472003518	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472003519	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
504472003520	conserved hypothetical integral membrane protein; Region: TIGR03766
504472003521	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
504472003522	PAS domain S-box; Region: sensory_box; TIGR00229
504472003523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472003524	putative active site [active]
504472003525	heme pocket [chemical binding]; other site
504472003526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472003527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472003528	dimer interface [polypeptide binding]; other site
504472003529	phosphorylation site [posttranslational modification]
504472003530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472003531	ATP binding site [chemical binding]; other site
504472003532	Mg2+ binding site [ion binding]; other site
504472003533	G-X-G motif; other site
504472003534	Response regulator receiver domain; Region: Response_reg; pfam00072
504472003535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472003536	active site
504472003537	phosphorylation site [posttranslational modification]
504472003538	intermolecular recognition site; other site
504472003539	dimerization interface [polypeptide binding]; other site
504472003540	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472003541	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472003542	ligand binding site [chemical binding]; other site
504472003543	flexible hinge region; other site
504472003544	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
504472003545	putative switch regulator; other site
504472003546	non-specific DNA interactions [nucleotide binding]; other site
504472003547	DNA binding site [nucleotide binding]
504472003548	sequence specific DNA binding site [nucleotide binding]; other site
504472003549	putative cAMP binding site [chemical binding]; other site
504472003550	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
504472003551	active site
504472003552	DNA polymerase IV; Validated; Region: PRK02406
504472003553	DNA binding site [nucleotide binding]
504472003554	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472003555	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003556	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472003557	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472003558	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472003559	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472003560	Uncharacterized conserved protein [Function unknown]; Region: COG1359
504472003561	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
504472003562	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
504472003563	active site
504472003564	Zn binding site [ion binding]; other site
504472003565	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
504472003566	phosphopeptide binding site; other site
504472003567	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472003568	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
504472003569	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
504472003570	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
504472003571	Catalytic domain of Protein Kinases; Region: PKc; cd00180
504472003572	active site
504472003573	ATP binding site [chemical binding]; other site
504472003574	substrate binding site [chemical binding]; other site
504472003575	activation loop (A-loop); other site
504472003576	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
504472003577	Catalytic domain of Protein Kinases; Region: PKc; cd00180
504472003578	active site
504472003579	ATP binding site [chemical binding]; other site
504472003580	substrate binding site [chemical binding]; other site
504472003581	activation loop (A-loop); other site
504472003582	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
504472003583	active site
504472003584	Putative carbohydrate binding domain; Region: CHB_HEX; cl03918
504472003585	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
504472003586	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
504472003587	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472003588	active site
504472003589	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
504472003590	Response regulator receiver domain; Region: Response_reg; pfam00072
504472003591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472003592	active site
504472003593	phosphorylation site [posttranslational modification]
504472003594	intermolecular recognition site; other site
504472003595	dimerization interface [polypeptide binding]; other site
504472003596	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472003597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472003598	active site
504472003599	phosphorylation site [posttranslational modification]
504472003600	intermolecular recognition site; other site
504472003601	dimerization interface [polypeptide binding]; other site
504472003602	LytTr DNA-binding domain; Region: LytTR; smart00850
504472003603	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472003604	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472003605	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472003606	DNA binding residues [nucleotide binding]
504472003607	Predicted transcriptional regulator [Transcription]; Region: COG2378
504472003608	HTH domain; Region: HTH_11; pfam08279
504472003609	WYL domain; Region: WYL; pfam13280
504472003610	Predicted acetyltransferase [General function prediction only]; Region: COG2388
504472003611	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472003612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472003613	active site
504472003614	phosphorylation site [posttranslational modification]
504472003615	intermolecular recognition site; other site
504472003616	dimerization interface [polypeptide binding]; other site
504472003617	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472003618	DNA binding site [nucleotide binding]
504472003619	Outer membrane efflux protein; Region: OEP; pfam02321
504472003620	Outer membrane efflux protein; Region: OEP; pfam02321
504472003621	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472003622	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472003623	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
504472003624	transcription termination factor Rho; Provisional; Region: PRK12608
504472003625	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
504472003626	RNA binding site [nucleotide binding]; other site
504472003627	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
504472003628	multimer interface [polypeptide binding]; other site
504472003629	Walker A motif; other site
504472003630	ATP binding site [chemical binding]; other site
504472003631	Walker B motif; other site
504472003632	pantothenate kinase; Reviewed; Region: PRK13320
504472003633	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
504472003634	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
504472003635	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472003636	Cytochrome c; Region: Cytochrom_C; pfam00034
504472003637	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
504472003638	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
504472003639	Cu(I) binding site [ion binding]; other site
504472003640	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
504472003641	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
504472003642	Walker A/P-loop; other site
504472003643	ATP binding site [chemical binding]; other site
504472003644	Q-loop/lid; other site
504472003645	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
504472003646	ABC transporter signature motif; other site
504472003647	Walker B; other site
504472003648	D-loop; other site
504472003649	H-loop/switch region; other site
504472003650	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
504472003651	Flavoprotein; Region: Flavoprotein; pfam02441
504472003652	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
504472003653	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
504472003654	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
504472003655	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472003656	OstA-like protein; Region: OstA_2; pfam13100
504472003657	OstA-like protein; Region: OstA; cl00844
504472003658	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
504472003659	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
504472003660	Ligand Binding Site [chemical binding]; other site
504472003661	TilS substrate C-terminal domain; Region: TilS_C; smart00977
504472003662	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472003663	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472003664	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472003665	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472003666	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472003667	ligand binding site [chemical binding]; other site
504472003668	DinB superfamily; Region: DinB_2; pfam12867
504472003669	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
504472003670	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472003671	NAD(P) binding site [chemical binding]; other site
504472003672	active site
504472003673	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
504472003674	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
504472003675	conserved cys residue [active]
504472003676	carboxylate-amine ligase; Provisional; Region: PRK13515
504472003677	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
504472003678	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472003679	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472003680	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472003681	DNA binding residues [nucleotide binding]
504472003682	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
504472003683	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
504472003684	Protein of unknown function DUF58; Region: DUF58; pfam01882
504472003685	MoxR-like ATPases [General function prediction only]; Region: COG0714
504472003686	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472003687	Walker A motif; other site
504472003688	ATP binding site [chemical binding]; other site
504472003689	Walker B motif; other site
504472003690	arginine finger; other site
504472003691	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
504472003692	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472003693	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472003694	Coenzyme A binding pocket [chemical binding]; other site
504472003695	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472003696	putative active site [active]
504472003697	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
504472003698	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
504472003699	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
504472003700	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
504472003701	GxxExxY protein; Region: GxxExxY; TIGR04256
504472003702	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
504472003703	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
504472003704	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472003705	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
504472003706	Putative esterase; Region: Esterase; pfam00756
504472003707	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003708	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003709	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
504472003710	active site
504472003711	catalytic residues [active]
504472003712	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003713	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
504472003714	NAD(P) binding site [chemical binding]; other site
504472003715	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
504472003716	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
504472003717	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
504472003718	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
504472003719	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
504472003720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472003721	FeS/SAM binding site; other site
504472003722	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003723	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
504472003724	RNA methyltransferase, RsmE family; Region: TIGR00046
504472003725	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
504472003726	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
504472003727	Fatty acid desaturase; Region: FA_desaturase; pfam00487
504472003728	Di-iron ligands [ion binding]; other site
504472003729	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
504472003730	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
504472003731	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472003732	E3 interaction surface; other site
504472003733	lipoyl attachment site [posttranslational modification]; other site
504472003734	e3 binding domain; Region: E3_binding; pfam02817
504472003735	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
504472003736	competence damage-inducible protein A; Provisional; Region: PRK00549
504472003737	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
504472003738	putative MPT binding site; other site
504472003739	Competence-damaged protein; Region: CinA; pfam02464
504472003740	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
504472003741	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
504472003742	apolar tunnel; other site
504472003743	heme binding site [chemical binding]; other site
504472003744	dimerization interface [polypeptide binding]; other site
504472003745	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
504472003746	ArsC family; Region: ArsC; pfam03960
504472003747	putative catalytic residues [active]
504472003748	gliding motility-associated protein GldC; Region: GldC; TIGR03515
504472003749	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
504472003750	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472003751	binding surface
504472003752	TPR motif; other site
504472003753	TPR repeat; Region: TPR_11; pfam13414
504472003754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
504472003755	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
504472003756	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
504472003757	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
504472003758	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
504472003759	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
504472003760	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
504472003761	putative acyl-acceptor binding pocket; other site
504472003762	WbqC-like protein family; Region: WbqC; pfam08889
504472003763	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
504472003764	Clp amino terminal domain; Region: Clp_N; pfam02861
504472003765	Clp amino terminal domain; Region: Clp_N; pfam02861
504472003766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472003767	Walker A motif; other site
504472003768	ATP binding site [chemical binding]; other site
504472003769	Walker B motif; other site
504472003770	arginine finger; other site
504472003771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472003772	Walker A motif; other site
504472003773	ATP binding site [chemical binding]; other site
504472003774	Walker B motif; other site
504472003775	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
504472003776	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472003777	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472003778	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
504472003779	putative active site [active]
504472003780	catalytic site [active]
504472003781	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
504472003782	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
504472003783	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
504472003784	NAD(P) binding site [chemical binding]; other site
504472003785	homotetramer interface [polypeptide binding]; other site
504472003786	homodimer interface [polypeptide binding]; other site
504472003787	active site
504472003788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472003789	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472003790	Walker A motif; other site
504472003791	ATP binding site [chemical binding]; other site
504472003792	Walker B motif; other site
504472003793	Family description; Region: UvrD_C_2; pfam13538
504472003794	HRDC domain; Region: HRDC; pfam00570
504472003795	Predicted membrane protein [Function unknown]; Region: COG2510
504472003796	Phosphoesterase family; Region: Phosphoesterase; pfam04185
504472003797	Phosphoesterase family; Region: Phosphoesterase; pfam04185
504472003798	Domain of unknown function (DUF756); Region: DUF756; pfam05506
504472003799	Domain of unknown function (DUF756); Region: DUF756; pfam05506
504472003800	ethanolamine permease; Region: 2A0305; TIGR00908
504472003801	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
504472003802	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
504472003803	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985
504472003804	Smr domain; Region: Smr; pfam01713
504472003805	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
504472003806	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
504472003807	ribosomal protein S16; Region: S16; TIGR00002
504472003808	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
504472003809	RimM N-terminal domain; Region: RimM; pfam01782
504472003810	PRC-barrel domain; Region: PRC; pfam05239
504472003811	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
504472003812	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
504472003813	Transglycosylase; Region: Transgly; pfam00912
504472003814	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
504472003815	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472003816	Coenzyme A binding pocket [chemical binding]; other site
504472003817	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
504472003818	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
504472003819	RNA binding surface [nucleotide binding]; other site
504472003820	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
504472003821	active site
504472003822	D-cysteine desulfhydrase; Validated; Region: PRK03910
504472003823	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
504472003824	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472003825	catalytic residue [active]
504472003826	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
504472003827	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
504472003828	active site
504472003829	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
504472003830	Phosphotransferase enzyme family; Region: APH; pfam01636
504472003831	putative active site [active]
504472003832	putative substrate binding site [chemical binding]; other site
504472003833	ATP binding site [chemical binding]; other site
504472003834	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
504472003835	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
504472003836	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
504472003837	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472003838	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
504472003839	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472003840	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472003841	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
504472003842	Fasciclin domain; Region: Fasciclin; pfam02469
504472003843	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
504472003844	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
504472003845	EcsC protein family; Region: EcsC; pfam12787
504472003846	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
504472003847	hypothetical protein; Provisional; Region: PRK00955
504472003848	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
504472003849	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
504472003850	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472003851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472003852	short chain dehydrogenase; Validated; Region: PRK06182
504472003853	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472003854	NADP binding site [chemical binding]; other site
504472003855	active site
504472003856	steroid binding site; other site
504472003857	Putative esterase; Region: Esterase; pfam00756
504472003858	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003859	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
504472003860	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003861	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003862	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
504472003863	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003864	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003865	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
504472003866	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
504472003867	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003868	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003869	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
504472003870	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003871	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003872	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
504472003873	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472003874	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003875	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
504472003876	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
504472003877	Putative esterase; Region: Esterase; pfam00756
504472003878	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472003879	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
504472003880	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
504472003881	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472003882	Fn3 associated; Region: Fn3_assoc; pfam13287
504472003883	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472003884	sugar binding site [chemical binding]; other site
504472003885	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
504472003886	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
504472003887	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472003888	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472003889	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
504472003890	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
504472003891	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
504472003892	active site
504472003893	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
504472003894	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472003895	active site
504472003896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
504472003897	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
504472003898	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
504472003899	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
504472003900	inhibitor binding site; inhibition site
504472003901	active site
504472003902	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472003903	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472003904	SusD family; Region: SusD; pfam07980
504472003905	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472003906	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472003907	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472003908	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472003909	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472003910	FecR protein; Region: FecR; pfam04773
504472003911	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472003912	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472003913	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472003914	DNA binding residues [nucleotide binding]
504472003915	putative chaperone; Provisional; Region: PRK11678
504472003916	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
504472003917	nucleotide binding site [chemical binding]; other site
504472003918	putative NEF/HSP70 interaction site [polypeptide binding]; other site
504472003919	SBD interface [polypeptide binding]; other site
504472003920	Sulfatase; Region: Sulfatase; cl17466
504472003921	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472003922	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
504472003923	Uncharacterized conserved protein [Function unknown]; Region: COG1262
504472003924	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
504472003925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472003926	Walker A/P-loop; other site
504472003927	ATP binding site [chemical binding]; other site
504472003928	Q-loop/lid; other site
504472003929	ABC transporter signature motif; other site
504472003930	Walker B; other site
504472003931	D-loop; other site
504472003932	H-loop/switch region; other site
504472003933	ABC transporter; Region: ABC_tran_2; pfam12848
504472003934	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472003935	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
504472003936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472003937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472003938	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
504472003939	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472003940	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472003941	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
504472003942	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
504472003943	OsmC-like protein; Region: OsmC; pfam02566
504472003944	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472003945	active site
504472003946	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
504472003947	Domain of unknown function DUF21; Region: DUF21; pfam01595
504472003948	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
504472003949	Transporter associated domain; Region: CorC_HlyC; smart01091
504472003950	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
504472003951	CcmE; Region: CcmE; cl00994
504472003952	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
504472003953	CcmB protein; Region: CcmB; cl17444
504472003954	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
504472003955	hypothetical protein; Provisional; Region: PRK10621
504472003956	FeoA domain; Region: FeoA; pfam04023
504472003957	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
504472003958	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
504472003959	G1 box; other site
504472003960	GTP/Mg2+ binding site [chemical binding]; other site
504472003961	Switch I region; other site
504472003962	G2 box; other site
504472003963	G3 box; other site
504472003964	Switch II region; other site
504472003965	G4 box; other site
504472003966	G5 box; other site
504472003967	Nucleoside recognition; Region: Gate; pfam07670
504472003968	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
504472003969	Nucleoside recognition; Region: Gate; pfam07670
504472003970	putative carbohydrate kinase; Provisional; Region: PRK10565
504472003971	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
504472003972	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
504472003973	putative substrate binding site [chemical binding]; other site
504472003974	putative ATP binding site [chemical binding]; other site
504472003975	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
504472003976	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
504472003977	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
504472003978	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
504472003979	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
504472003980	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472003981	active site residue [active]
504472003982	heat shock protein 90; Provisional; Region: PRK05218
504472003983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472003984	ATP binding site [chemical binding]; other site
504472003985	Mg2+ binding site [ion binding]; other site
504472003986	G-X-G motif; other site
504472003987	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
504472003988	AAA domain; Region: AAA_30; pfam13604
504472003989	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472003990	Family description; Region: UvrD_C_2; pfam13538
504472003991	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
504472003992	FOG: CBS domain [General function prediction only]; Region: COG0517
504472003993	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
504472003994	nudix motif; other site
504472003995	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
504472003996	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
504472003997	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
504472003998	active site
504472003999	(T/H)XGH motif; other site
504472004000	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
504472004001	active site
504472004002	Ap6A binding site [chemical binding]; other site
504472004003	nudix motif; other site
504472004004	metal binding site [ion binding]; metal-binding site
504472004005	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
504472004006	Domain of unknown function DUF21; Region: DUF21; pfam01595
504472004007	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
504472004008	Transporter associated domain; Region: CorC_HlyC; smart01091
504472004009	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472004010	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472004011	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
504472004012	Walker A/P-loop; other site
504472004013	ATP binding site [chemical binding]; other site
504472004014	Q-loop/lid; other site
504472004015	ABC transporter signature motif; other site
504472004016	Walker B; other site
504472004017	D-loop; other site
504472004018	H-loop/switch region; other site
504472004019	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
504472004020	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
504472004021	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
504472004022	active site
504472004023	HIGH motif; other site
504472004024	KMSKS motif; other site
504472004025	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
504472004026	tRNA binding surface [nucleotide binding]; other site
504472004027	anticodon binding site; other site
504472004028	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
504472004029	dimer interface [polypeptide binding]; other site
504472004030	putative tRNA-binding site [nucleotide binding]; other site
504472004031	Predicted ATPases [General function prediction only]; Region: COG1106
504472004032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472004033	Walker A/P-loop; other site
504472004034	ATP binding site [chemical binding]; other site
504472004035	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
504472004036	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
504472004037	putative NADP binding site [chemical binding]; other site
504472004038	putative substrate binding site [chemical binding]; other site
504472004039	active site
504472004040	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472004041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472004042	binding surface
504472004043	TPR motif; other site
504472004044	TPR repeat; Region: TPR_11; pfam13414
504472004045	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472004046	binding surface
504472004047	TPR repeat; Region: TPR_11; pfam13414
504472004048	TPR motif; other site
504472004049	TPR repeat; Region: TPR_11; pfam13414
504472004050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472004051	binding surface
504472004052	TPR motif; other site
504472004053	TPR repeat; Region: TPR_11; pfam13414
504472004054	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472004055	binding surface
504472004056	TPR repeat; Region: TPR_11; pfam13414
504472004057	TPR motif; other site
504472004058	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
504472004059	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472004060	hydroxyglutarate oxidase; Provisional; Region: PRK11728
504472004061	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
504472004062	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
504472004063	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
504472004064	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
504472004065	inhibitor site; inhibition site
504472004066	active site
504472004067	dimer interface [polypeptide binding]; other site
504472004068	catalytic residue [active]
504472004069	Cupin domain; Region: Cupin_2; cl17218
504472004070	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
504472004071	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472004072	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472004073	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472004074	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472004075	DNA binding site [nucleotide binding]
504472004076	domain linker motif; other site
504472004077	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472004078	dimerization interface [polypeptide binding]; other site
504472004079	ligand binding site [chemical binding]; other site
504472004080	maltose phosphorylase; Provisional; Region: PRK13807
504472004081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472004082	binding surface
504472004083	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472004084	TPR motif; other site
504472004085	TPR repeat; Region: TPR_11; pfam13414
504472004086	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
504472004087	active site
504472004088	catalytic triad [active]
504472004089	oxyanion hole [active]
504472004090	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
504472004091	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
504472004092	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
504472004093	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
504472004094	catalytic residues [active]
504472004095	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
504472004096	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
504472004097	WYL domain; Region: WYL; pfam13280
504472004098	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
504472004099	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
504472004100	hypothetical protein; Reviewed; Region: PRK09588
504472004101	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
504472004102	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
504472004103	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472004104	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
504472004105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472004106	putative substrate translocation pore; other site
504472004107	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
504472004108	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
504472004109	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
504472004110	Mechanosensitive ion channel; Region: MS_channel; pfam00924
504472004111	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
504472004112	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
504472004113	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472004114	catalytic residue [active]
504472004115	CCC1; Region: CCC1; cd02435
504472004116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
504472004117	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
504472004118	ApbE family; Region: ApbE; pfam02424
504472004119	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
504472004120	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472004121	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
504472004122	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472004123	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472004124	catalytic residues [active]
504472004125	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
504472004126	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
504472004127	cystathionine gamma-synthase; Provisional; Region: PRK07811
504472004128	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
504472004129	homodimer interface [polypeptide binding]; other site
504472004130	substrate-cofactor binding pocket; other site
504472004131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472004132	catalytic residue [active]
504472004133	enoyl-CoA hydratase; Provisional; Region: PRK06142
504472004134	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472004135	substrate binding site [chemical binding]; other site
504472004136	oxyanion hole (OAH) forming residues; other site
504472004137	trimer interface [polypeptide binding]; other site
504472004138	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
504472004139	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
504472004140	NAD(P) binding site [chemical binding]; other site
504472004141	substrate binding site [chemical binding]; other site
504472004142	homotetramer interface [polypeptide binding]; other site
504472004143	active site
504472004144	homodimer interface [polypeptide binding]; other site
504472004145	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004146	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472004147	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472004148	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
504472004149	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472004150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472004151	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
504472004152	dimerization interface [polypeptide binding]; other site
504472004153	BNR repeat-like domain; Region: BNR_2; pfam13088
504472004154	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
504472004155	metal-binding site [ion binding]
504472004156	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472004157	kynureninase; Region: kynureninase; TIGR01814
504472004158	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472004159	catalytic residue [active]
504472004160	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
504472004161	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
504472004162	GrpE; Region: GrpE; pfam01025
504472004163	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
504472004164	dimer interface [polypeptide binding]; other site
504472004165	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
504472004166	chaperone protein DnaJ; Provisional; Region: PRK14289
504472004167	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
504472004168	HSP70 interaction site [polypeptide binding]; other site
504472004169	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
504472004170	substrate binding site [polypeptide binding]; other site
504472004171	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
504472004172	Zn binding sites [ion binding]; other site
504472004173	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
504472004174	dimer interface [polypeptide binding]; other site
504472004175	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
504472004176	tetramer interfaces [polypeptide binding]; other site
504472004177	binuclear metal-binding site [ion binding]; other site
504472004178	Predicted membrane protein [Function unknown]; Region: COG2246
504472004179	GtrA-like protein; Region: GtrA; pfam04138
504472004180	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004181	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
504472004182	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
504472004183	active site
504472004184	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
504472004185	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472004186	Carboxylesterase family; Region: COesterase; pfam00135
504472004187	substrate binding pocket [chemical binding]; other site
504472004188	catalytic triad [active]
504472004189	Putative esterase; Region: Esterase; pfam00756
504472004190	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472004191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
504472004192	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
504472004193	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472004194	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
504472004195	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
504472004196	dimer interface [polypeptide binding]; other site
504472004197	active site
504472004198	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
504472004199	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
504472004200	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
504472004201	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
504472004202	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
504472004203	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
504472004204	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
504472004205	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
504472004206	tetramer interface [polypeptide binding]; other site
504472004207	active site
504472004208	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
504472004209	active site
504472004210	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
504472004211	multimer interface [polypeptide binding]; other site
504472004212	heterodimer interface [polypeptide binding]; other site
504472004213	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
504472004214	active site
504472004215	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
504472004216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472004217	RES domain; Region: RES; pfam08808
504472004218	hypothetical protein; Provisional; Region: PRK06847
504472004219	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
504472004220	Putative cyclase; Region: Cyclase; pfam04199
504472004221	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
504472004222	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
504472004223	XisH protein; Region: XisH; pfam08814
504472004224	XisI protein; Region: XisI; pfam08869
504472004225	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
504472004226	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472004227	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
504472004228	tetramer interface [polypeptide binding]; other site
504472004229	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
504472004230	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
504472004231	active site
504472004232	metal binding site [ion binding]; metal-binding site
504472004233	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472004234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472004235	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
504472004236	Malonate transporter MadL subunit; Region: MadL; cl04273
504472004237	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
504472004238	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
504472004239	acyl-activating enzyme (AAE) consensus motif; other site
504472004240	active site
504472004241	AMP binding site [chemical binding]; other site
504472004242	CoA binding site [chemical binding]; other site
504472004243	benzoate transport; Region: 2A0115; TIGR00895
504472004244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472004245	putative substrate translocation pore; other site
504472004246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472004247	putative substrate translocation pore; other site
504472004248	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
504472004249	Tannase and feruloyl esterase; Region: Tannase; pfam07519
504472004250	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
504472004251	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
504472004252	substrate binding site [chemical binding]; other site
504472004253	THF binding site; other site
504472004254	zinc-binding site [ion binding]; other site
504472004255	feruloyl-CoA synthase; Reviewed; Region: PRK08180
504472004256	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
504472004257	acyl-activating enzyme (AAE) consensus motif; other site
504472004258	putative AMP binding site [chemical binding]; other site
504472004259	putative active site [active]
504472004260	putative CoA binding site [chemical binding]; other site
504472004261	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472004262	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
504472004263	substrate binding site [chemical binding]; other site
504472004264	oxyanion hole (OAH) forming residues; other site
504472004265	trimer interface [polypeptide binding]; other site
504472004266	hypothetical protein; Provisional; Region: PRK00872
504472004267	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
504472004268	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
504472004269	Asp-box motif; other site
504472004270	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
504472004271	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
504472004272	Walker A/P-loop; other site
504472004273	ATP binding site [chemical binding]; other site
504472004274	Q-loop/lid; other site
504472004275	ABC transporter signature motif; other site
504472004276	Walker B; other site
504472004277	D-loop; other site
504472004278	H-loop/switch region; other site
504472004279	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
504472004280	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
504472004281	ABC-ATPase subunit  interface; other site
504472004282	dimer interface [polypeptide binding]; other site
504472004283	putative PBP binding regions; other site
504472004284	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
504472004285	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
504472004286	intersubunit interface [polypeptide binding]; other site
504472004287	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004288	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472004289	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472004290	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
504472004291	Asp-box motif; other site
504472004292	BNR repeat-like domain; Region: BNR_2; pfam13088
504472004293	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
504472004294	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004295	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
504472004296	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472004297	N-terminal plug; other site
504472004298	ligand-binding site [chemical binding]; other site
504472004299	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
504472004300	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
504472004301	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
504472004302	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
504472004303	catalytic site [active]
504472004304	Asp-box motif; other site
504472004305	BNR repeat-like domain; Region: BNR_2; pfam13088
504472004306	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
504472004307	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
504472004308	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
504472004309	homodimer interface [polypeptide binding]; other site
504472004310	NADP binding site [chemical binding]; other site
504472004311	substrate binding site [chemical binding]; other site
504472004312	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
504472004313	HNH endonuclease; Region: HNH_3; pfam13392
504472004314	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
504472004315	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
504472004316	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
504472004317	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
504472004318	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
504472004319	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004320	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472004321	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472004322	fructokinase; Reviewed; Region: PRK09557
504472004323	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
504472004324	nucleotide binding site [chemical binding]; other site
504472004325	Glucokinase; Region: Glucokinase; cl17310
504472004326	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
504472004327	Peroxiredoxin (PRX) family; composed of the different classes of PRXs including many proteins originally known as bacterioferritin comigratory proteins (BCP), based on their electrophoretic mobility before their function was identified. PRXs are...; Region: PRX_family; cd02971
504472004328	catalytic triad [active]
504472004329	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472004330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472004331	S-adenosylmethionine binding site [chemical binding]; other site
504472004332	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472004333	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472004334	WHG domain; Region: WHG; pfam13305
504472004335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472004336	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472004337	NAD(P) binding site [chemical binding]; other site
504472004338	active site
504472004339	Uncharacterized conserved protein [Function unknown]; Region: COG1284
504472004340	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
504472004341	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
504472004342	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
504472004343	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
504472004344	dimer interface [polypeptide binding]; other site
504472004345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472004346	catalytic residue [active]
504472004347	serine O-acetyltransferase; Region: cysE; TIGR01172
504472004348	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
504472004349	trimer interface [polypeptide binding]; other site
504472004350	active site
504472004351	substrate binding site [chemical binding]; other site
504472004352	CoA binding site [chemical binding]; other site
504472004353	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472004354	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
504472004355	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
504472004356	DNA binding site [nucleotide binding]
504472004357	active site
504472004358	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
504472004359	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
504472004360	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
504472004361	hydrophobic ligand binding site; other site
504472004362	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472004363	putative active site [active]
504472004364	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472004365	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472004366	catalytic residues [active]
504472004367	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
504472004368	Na binding site [ion binding]; other site
504472004369	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
504472004370	recombination protein RecR; Reviewed; Region: recR; PRK00076
504472004371	RecR protein; Region: RecR; pfam02132
504472004372	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
504472004373	putative active site [active]
504472004374	putative metal-binding site [ion binding]; other site
504472004375	tetramer interface [polypeptide binding]; other site
504472004376	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
504472004377	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
504472004378	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
504472004379	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
504472004380	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
504472004381	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
504472004382	Chromate transporter; Region: Chromate_transp; pfam02417
504472004383	Chromate transporter; Region: Chromate_transp; pfam02417
504472004384	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
504472004385	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
504472004386	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
504472004387	GDP-binding site [chemical binding]; other site
504472004388	ACT binding site; other site
504472004389	IMP binding site; other site
504472004390	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
504472004391	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
504472004392	metal binding site 2 [ion binding]; metal-binding site
504472004393	putative DNA binding helix; other site
504472004394	metal binding site 1 [ion binding]; metal-binding site
504472004395	dimer interface [polypeptide binding]; other site
504472004396	structural Zn2+ binding site [ion binding]; other site
504472004397	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
504472004398	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
504472004399	Zn2+ binding site [ion binding]; other site
504472004400	Mg2+ binding site [ion binding]; other site
504472004401	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
504472004402	synthetase active site [active]
504472004403	NTP binding site [chemical binding]; other site
504472004404	metal binding site [ion binding]; metal-binding site
504472004405	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
504472004406	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
504472004407	trigger factor; Region: tig; TIGR00115
504472004408	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
504472004409	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
504472004410	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472004411	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472004412	active site
504472004413	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
504472004414	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
504472004415	active site
504472004416	YceG-like family; Region: YceG; pfam02618
504472004417	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
504472004418	dimerization interface [polypeptide binding]; other site
504472004419	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
504472004420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472004421	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472004422	putative substrate translocation pore; other site
504472004423	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
504472004424	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
504472004425	putative active site [active]
504472004426	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472004427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472004428	Walker A/P-loop; other site
504472004429	ATP binding site [chemical binding]; other site
504472004430	Q-loop/lid; other site
504472004431	ABC transporter signature motif; other site
504472004432	Walker B; other site
504472004433	D-loop; other site
504472004434	H-loop/switch region; other site
504472004435	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472004436	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472004437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472004438	non-specific DNA binding site [nucleotide binding]; other site
504472004439	salt bridge; other site
504472004440	sequence-specific DNA binding site [nucleotide binding]; other site
504472004441	Protein of unknown function (DUF3972); Region: DUF3972; pfam13118
504472004442	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
504472004443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472004444	Walker A motif; other site
504472004445	ATP binding site [chemical binding]; other site
504472004446	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
504472004447	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
504472004448	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
504472004449	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
504472004450	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
504472004451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472004452	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472004453	NAD(P) binding site [chemical binding]; other site
504472004454	active site
504472004455	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472004456	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472004457	ligand binding site [chemical binding]; other site
504472004458	flexible hinge region; other site
504472004459	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
504472004460	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
504472004461	inhibitor-cofactor binding pocket; inhibition site
504472004462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472004463	catalytic residue [active]
504472004464	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494
504472004465	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
504472004466	Na binding site [ion binding]; other site
504472004467	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
504472004468	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472004469	Cellulose binding domain; Region: CBM_3; cl03026
504472004470	Cellulose binding domain; Region: CBM_3; pfam00942
504472004471	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472004472	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036
504472004473	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
504472004474	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
504472004475	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472004476	TPR repeat; Region: TPR_11; pfam13414
504472004477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
504472004478	TPR motif; other site
504472004479	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
504472004480	nudix motif; other site
504472004481	Protein of unknown function (DUF983); Region: DUF983; cl02211
504472004482	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
504472004483	Predicted amidohydrolase [General function prediction only]; Region: COG0388
504472004484	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
504472004485	putative active site [active]
504472004486	catalytic triad [active]
504472004487	putative dimer interface [polypeptide binding]; other site
504472004488	Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493
504472004489	active site
504472004490	catalytic triad [active]
504472004491	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472004492	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
504472004493	AAA domain; Region: AAA_13; pfam13166
504472004494	methionine sulfoxide reductase A; Provisional; Region: PRK14054
504472004495	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
504472004496	active site
504472004497	dinuclear metal binding site [ion binding]; other site
504472004498	dimerization interface [polypeptide binding]; other site
504472004499	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
504472004500	PAS domain S-box; Region: sensory_box; TIGR00229
504472004501	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472004502	putative active site [active]
504472004503	heme pocket [chemical binding]; other site
504472004504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472004505	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472004506	putative active site [active]
504472004507	heme pocket [chemical binding]; other site
504472004508	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472004509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472004510	putative active site [active]
504472004511	heme pocket [chemical binding]; other site
504472004512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472004513	dimer interface [polypeptide binding]; other site
504472004514	phosphorylation site [posttranslational modification]
504472004515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472004516	ATP binding site [chemical binding]; other site
504472004517	Mg2+ binding site [ion binding]; other site
504472004518	G-X-G motif; other site
504472004519	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
504472004520	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
504472004521	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
504472004522	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
504472004523	ADP-ribose binding site [chemical binding]; other site
504472004524	dimer interface [polypeptide binding]; other site
504472004525	active site
504472004526	nudix motif; other site
504472004527	metal binding site [ion binding]; metal-binding site
504472004528	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
504472004529	GH3 auxin-responsive promoter; Region: GH3; pfam03321
504472004530	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
504472004531	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472004532	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472004533	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472004534	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
504472004535	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472004536	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
504472004537	active site
504472004538	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
504472004539	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
504472004540	active site residue [active]
504472004541	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
504472004542	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
504472004543	Substrate-binding site [chemical binding]; other site
504472004544	Substrate specificity [chemical binding]; other site
504472004545	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472004546	PAS fold; Region: PAS_4; pfam08448
504472004547	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472004548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472004549	dimer interface [polypeptide binding]; other site
504472004550	phosphorylation site [posttranslational modification]
504472004551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472004552	ATP binding site [chemical binding]; other site
504472004553	Mg2+ binding site [ion binding]; other site
504472004554	G-X-G motif; other site
504472004555	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
504472004556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472004557	short chain dehydrogenase; Provisional; Region: PRK06181
504472004558	NAD(P) binding site [chemical binding]; other site
504472004559	active site
504472004560	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472004561	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
504472004562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472004563	S-adenosylmethionine binding site [chemical binding]; other site
504472004564	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
504472004565	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
504472004566	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
504472004567	Uncharacterized conserved protein [Function unknown]; Region: COG4938
504472004568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472004569	Walker A/P-loop; other site
504472004570	ATP binding site [chemical binding]; other site
504472004571	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
504472004572	glycyl-tRNA synthetase; Provisional; Region: PRK04173
504472004573	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
504472004574	motif 1; other site
504472004575	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
504472004576	active site
504472004577	motif 2; other site
504472004578	motif 3; other site
504472004579	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
504472004580	anticodon binding site; other site
504472004581	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
504472004582	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
504472004583	CysD dimerization site [polypeptide binding]; other site
504472004584	G1 box; other site
504472004585	putative GEF interaction site [polypeptide binding]; other site
504472004586	GTP/Mg2+ binding site [chemical binding]; other site
504472004587	Switch I region; other site
504472004588	G2 box; other site
504472004589	G3 box; other site
504472004590	Switch II region; other site
504472004591	G4 box; other site
504472004592	G5 box; other site
504472004593	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
504472004594	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
504472004595	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
504472004596	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
504472004597	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
504472004598	Active Sites [active]
504472004599	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
504472004600	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
504472004601	Active Sites [active]
504472004602	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472004603	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472004604	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
504472004605	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
504472004606	homodimer interface [polypeptide binding]; other site
504472004607	substrate-cofactor binding pocket; other site
504472004608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472004609	catalytic residue [active]
504472004610	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
504472004611	Protein of unknown function (DUF819); Region: DUF819; cl02317
504472004612	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004613	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472004614	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472004615	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472004616	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472004617	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
504472004618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
504472004619	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
504472004620	potential frameshift: common BLAST hit: gi|255530634|ref|YP_003091006.1| alkyl hydroperoxide reductase/ thiol specific antioxidant/ Mal
504472004621	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472004622	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472004623	catalytic residues [active]
504472004624	Homeodomain-like domain; Region: HTH_23; pfam13384
504472004625	Winged helix-turn helix; Region: HTH_29; pfam13551
504472004626	Homeodomain-like domain; Region: HTH_32; pfam13565
504472004627	Winged helix-turn helix; Region: HTH_33; pfam13592
504472004628	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472004629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472004630	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
504472004631	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
504472004632	active site
504472004633	catalytic residues [active]
504472004634	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
504472004635	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472004636	active site
504472004637	HIGH motif; other site
504472004638	nucleotide binding site [chemical binding]; other site
504472004639	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472004640	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
504472004641	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472004642	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472004643	active site
504472004644	KMSKS motif; other site
504472004645	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
504472004646	tRNA binding surface [nucleotide binding]; other site
504472004647	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
504472004648	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
504472004649	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
504472004650	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
504472004651	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
504472004652	putative active site [active]
504472004653	catalytic site [active]
504472004654	putative metal binding site [ion binding]; other site
504472004655	oligomer interface [polypeptide binding]; other site
504472004656	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472004657	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472004658	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472004659	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
504472004660	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472004661	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
504472004662	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
504472004663	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
504472004664	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004665	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472004666	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472004667	N-terminal plug; other site
504472004668	ligand-binding site [chemical binding]; other site
504472004669	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
504472004670	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
504472004671	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472004672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472004673	active site
504472004674	phosphorylation site [posttranslational modification]
504472004675	intermolecular recognition site; other site
504472004676	dimerization interface [polypeptide binding]; other site
504472004677	LytTr DNA-binding domain; Region: LytTR; smart00850
504472004678	Histidine kinase; Region: His_kinase; pfam06580
504472004679	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
504472004680	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472004681	NAD binding site [chemical binding]; other site
504472004682	substrate binding site [chemical binding]; other site
504472004683	putative active site [active]
504472004684	Rrf2 family protein; Region: rrf2_super; TIGR00738
504472004685	Transcriptional regulator; Region: Rrf2; pfam02082
504472004686	Transcriptional regulator; Region: Rrf2; cl17282
504472004687	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
504472004688	Predicted amidohydrolase [General function prediction only]; Region: COG0388
504472004689	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
504472004690	putative active site [active]
504472004691	catalytic triad [active]
504472004692	putative dimer interface [polypeptide binding]; other site
504472004693	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
504472004694	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
504472004695	tetramer interface [polypeptide binding]; other site
504472004696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472004697	catalytic residue [active]
504472004698	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
504472004699	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472004700	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472004701	ligand binding site [chemical binding]; other site
504472004702	Uncharacterized conserved protein [Function unknown]; Region: COG3743
504472004703	Uncharacterized conserved protein [Function unknown]; Region: COG3743
504472004704	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
504472004705	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
504472004706	minor groove reading motif; other site
504472004707	helix-hairpin-helix signature motif; other site
504472004708	substrate binding pocket [chemical binding]; other site
504472004709	active site
504472004710	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472004711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472004712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472004713	dimer interface [polypeptide binding]; other site
504472004714	phosphorylation site [posttranslational modification]
504472004715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472004716	ATP binding site [chemical binding]; other site
504472004717	Mg2+ binding site [ion binding]; other site
504472004718	G-X-G motif; other site
504472004719	Response regulator receiver domain; Region: Response_reg; pfam00072
504472004720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472004721	active site
504472004722	phosphorylation site [posttranslational modification]
504472004723	intermolecular recognition site; other site
504472004724	dimerization interface [polypeptide binding]; other site
504472004725	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472004726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472004727	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
504472004728	hydrophobic ligand binding site; other site
504472004729	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
504472004730	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
504472004731	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
504472004732	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
504472004733	Walker A/P-loop; other site
504472004734	ATP binding site [chemical binding]; other site
504472004735	Q-loop/lid; other site
504472004736	ABC transporter signature motif; other site
504472004737	Walker B; other site
504472004738	D-loop; other site
504472004739	H-loop/switch region; other site
504472004740	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
504472004741	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
504472004742	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
504472004743	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
504472004744	Actin depolymerization factor/cofilin- and gelsolin-like domains; Region: ADF_gelsolin; cl15697
504472004745	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
504472004746	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
504472004747	NAD(P) binding site [chemical binding]; other site
504472004748	catalytic residues [active]
504472004749	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472004750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472004751	non-specific DNA binding site [nucleotide binding]; other site
504472004752	salt bridge; other site
504472004753	sequence-specific DNA binding site [nucleotide binding]; other site
504472004754	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
504472004755	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
504472004756	dimerization interface 3.5A [polypeptide binding]; other site
504472004757	active site
504472004758	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
504472004759	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
504472004760	metal-binding site
504472004761	DinB superfamily; Region: DinB_2; pfam12867
504472004762	maltose phosphorylase; Provisional; Region: PRK13807
504472004763	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
504472004764	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
504472004765	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
504472004766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472004767	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
504472004768	AMP binding site [chemical binding]; other site
504472004769	active site
504472004770	acyl-activating enzyme (AAE) consensus motif; other site
504472004771	CoA binding site [chemical binding]; other site
504472004772	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
504472004773	iron-sulfur cluster [ion binding]; other site
504472004774	[2Fe-2S] cluster binding site [ion binding]; other site
504472004775	Protein of unknown function (DUF2452); Region: DUF2452; pfam10504
504472004776	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472004777	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
504472004778	substrate binding site [chemical binding]; other site
504472004779	oxyanion hole (OAH) forming residues; other site
504472004780	trimer interface [polypeptide binding]; other site
504472004781	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472004782	Two component regulator propeller; Region: Reg_prop; pfam07494
504472004783	Two component regulator propeller; Region: Reg_prop; pfam07494
504472004784	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472004785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472004786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472004787	dimer interface [polypeptide binding]; other site
504472004788	phosphorylation site [posttranslational modification]
504472004789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472004790	ATP binding site [chemical binding]; other site
504472004791	Mg2+ binding site [ion binding]; other site
504472004792	G-X-G motif; other site
504472004793	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472004794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472004795	active site
504472004796	phosphorylation site [posttranslational modification]
504472004797	intermolecular recognition site; other site
504472004798	dimerization interface [polypeptide binding]; other site
504472004799	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472004800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472004801	active site
504472004802	phosphorylation site [posttranslational modification]
504472004803	intermolecular recognition site; other site
504472004804	dimerization interface [polypeptide binding]; other site
504472004805	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
504472004806	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472004807	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472004808	catalytic residue [active]
504472004809	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472004810	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472004811	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472004812	Uncharacterized conserved protein [Function unknown]; Region: COG3268
504472004813	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472004814	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472004815	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472004816	FtsX-like permease family; Region: FtsX; pfam02687
504472004817	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472004818	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540
504472004819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472004820	Walker A/P-loop; other site
504472004821	ATP binding site [chemical binding]; other site
504472004822	Q-loop/lid; other site
504472004823	ABC transporter signature motif; other site
504472004824	Walker B; other site
504472004825	D-loop; other site
504472004826	H-loop/switch region; other site
504472004827	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472004828	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472004829	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472004830	helicase 45; Provisional; Region: PTZ00424
504472004831	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
504472004832	ATP binding site [chemical binding]; other site
504472004833	Mg++ binding site [ion binding]; other site
504472004834	motif III; other site
504472004835	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472004836	nucleotide binding region [chemical binding]; other site
504472004837	ATP-binding site [chemical binding]; other site
504472004838	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472004839	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472004840	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472004841	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472004842	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472004843	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472004844	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472004845	Amidohydrolase; Region: Amidohydro_4; pfam13147
504472004846	active site
504472004847	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472004848	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
504472004849	active site
504472004850	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472004851	active site
504472004852	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
504472004853	metal ion-dependent adhesion site (MIDAS); other site
504472004854	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472004855	ligand binding site [chemical binding]; other site
504472004856	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
504472004857	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
504472004858	B12 binding site [chemical binding]; other site
504472004859	Radical SAM superfamily; Region: Radical_SAM; pfam04055
504472004860	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
504472004861	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472004862	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472004863	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
504472004864	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472004865	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472004866	TPR repeat; Region: TPR_11; pfam13414
504472004867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472004868	binding surface
504472004869	TPR motif; other site
504472004870	TPR repeat; Region: TPR_11; pfam13414
504472004871	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472004872	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472004873	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472004874	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472004875	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472004876	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472004877	ligand binding site [chemical binding]; other site
504472004878	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
504472004879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472004880	FeS/SAM binding site; other site
504472004881	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
504472004882	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
504472004883	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
504472004884	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
504472004885	histidinol dehydrogenase; Region: hisD; TIGR00069
504472004886	NAD binding site [chemical binding]; other site
504472004887	dimerization interface [polypeptide binding]; other site
504472004888	product binding site; other site
504472004889	substrate binding site [chemical binding]; other site
504472004890	zinc binding site [ion binding]; other site
504472004891	catalytic residues [active]
504472004892	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
504472004893	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472004894	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472004895	catalytic residue [active]
504472004896	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
504472004897	active site
504472004898	catalytic residues [active]
504472004899	metal binding site [ion binding]; metal-binding site
504472004900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472004901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472004902	Coenzyme A binding pocket [chemical binding]; other site
504472004903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
504472004904	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472004905	Histidine kinase; Region: His_kinase; pfam06580
504472004906	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
504472004907	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
504472004908	Histidine kinase; Region: His_kinase; pfam06580
504472004909	Histidine kinase; Region: His_kinase; pfam06580
504472004910	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472004911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472004912	active site
504472004913	phosphorylation site [posttranslational modification]
504472004914	intermolecular recognition site; other site
504472004915	dimerization interface [polypeptide binding]; other site
504472004916	LytTr DNA-binding domain; Region: LytTR; smart00850
504472004917	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
504472004918	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472004919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472004920	homodimer interface [polypeptide binding]; other site
504472004921	catalytic residue [active]
504472004922	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
504472004923	Family description; Region: UvrD_C_2; pfam13538
504472004924	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472004925	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
504472004926	active site
504472004927	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
504472004928	FAD binding site [chemical binding]; other site
504472004929	rhamnose-proton symporter; Provisional; Region: PRK13499
504472004930	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
504472004931	short chain dehydrogenase; Validated; Region: PRK08324
504472004932	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
504472004933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472004934	NAD(P) binding site [chemical binding]; other site
504472004935	active site
504472004936	Transposase IS200 like; Region: Y1_Tnp; pfam01797
504472004937	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
504472004938	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
504472004939	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
504472004940	nucleotide binding site [chemical binding]; other site
504472004941	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
504472004942	Domain of unknown function (DUF718); Region: DUF718; pfam05336
504472004943	BNR repeat-like domain; Region: BNR_2; pfam13088
504472004944	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
504472004945	Asp-box motif; other site
504472004946	catalytic site [active]
504472004947	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
504472004948	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
504472004949	mce related protein; Region: MCE; pfam02470
504472004950	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
504472004951	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
504472004952	Walker A/P-loop; other site
504472004953	ATP binding site [chemical binding]; other site
504472004954	Q-loop/lid; other site
504472004955	ABC transporter signature motif; other site
504472004956	Walker B; other site
504472004957	D-loop; other site
504472004958	H-loop/switch region; other site
504472004959	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
504472004960	Permease; Region: Permease; pfam02405
504472004961	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
504472004962	S1 domain; Region: S1_2; pfam13509
504472004963	S1 domain; Region: S1_2; pfam13509
504472004964	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
504472004965	N-acetyl-D-glucosamine binding site [chemical binding]; other site
504472004966	catalytic residue [active]
504472004967	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472004968	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472004969	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472004970	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472004971	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
504472004972	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
504472004973	active site
504472004974	substrate binding site [chemical binding]; other site
504472004975	FMN binding site [chemical binding]; other site
504472004976	putative catalytic residues [active]
504472004977	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
504472004978	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472004979	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472004980	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
504472004981	Rrf2 family protein; Region: rrf2_super; TIGR00738
504472004982	Transcriptional regulator; Region: Rrf2; pfam02082
504472004983	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
504472004984	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
504472004985	Hemerythrin-like domain; Region: Hr-like; cd12108
504472004986	dihydroxy-acid dehydratase; Validated; Region: PRK06131
504472004987	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472004988	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
504472004989	classical (c) SDRs; Region: SDR_c; cd05233
504472004990	NAD(P) binding site [chemical binding]; other site
504472004991	active site
504472004992	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
504472004993	EamA-like transporter family; Region: EamA; pfam00892
504472004994	EamA-like transporter family; Region: EamA; pfam00892
504472004995	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
504472004996	Leucine-rich repeats; other site
504472004997	Leucine rich repeat; Region: LRR_8; pfam13855
504472004998	Substrate binding site [chemical binding]; other site
504472004999	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
504472005000	Leucine rich repeat; Region: LRR_8; pfam13855
504472005001	Leucine rich repeat; Region: LRR_8; pfam13855
504472005002	Leucine rich repeat; Region: LRR_8; pfam13855
504472005003	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472005004	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472005005	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472005006	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472005007	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472005008	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472005009	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472005010	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472005011	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472005012	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472005013	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472005014	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472005015	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472005016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005017	active site
504472005018	phosphorylation site [posttranslational modification]
504472005019	intermolecular recognition site; other site
504472005020	dimerization interface [polypeptide binding]; other site
504472005021	LytTr DNA-binding domain; Region: LytTR; smart00850
504472005022	Histidine kinase; Region: His_kinase; pfam06580
504472005023	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472005024	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472005025	Walker A/P-loop; other site
504472005026	ATP binding site [chemical binding]; other site
504472005027	Q-loop/lid; other site
504472005028	ABC transporter signature motif; other site
504472005029	Walker B; other site
504472005030	D-loop; other site
504472005031	H-loop/switch region; other site
504472005032	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
504472005033	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005034	FtsX-like permease family; Region: FtsX; pfam02687
504472005035	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472005036	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472005037	Outer membrane efflux protein; Region: OEP; pfam02321
504472005038	Outer membrane efflux protein; Region: OEP; pfam02321
504472005039	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472005040	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472005041	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472005042	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
504472005043	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
504472005044	30S subunit binding site; other site
504472005045	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
504472005046	NHAD transporter family protein; Provisional; Region: PLN00137
504472005047	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472005048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005049	active site
504472005050	phosphorylation site [posttranslational modification]
504472005051	intermolecular recognition site; other site
504472005052	dimerization interface [polypeptide binding]; other site
504472005053	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472005054	DNA binding site [nucleotide binding]
504472005055	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472005056	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472005057	dimerization interface [polypeptide binding]; other site
504472005058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005059	dimer interface [polypeptide binding]; other site
504472005060	phosphorylation site [posttranslational modification]
504472005061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005062	ATP binding site [chemical binding]; other site
504472005063	G-X-G motif; other site
504472005064	CsbD-like; Region: CsbD; pfam05532
504472005065	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
504472005066	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
504472005067	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
504472005068	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
504472005069	active site
504472005070	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
504472005071	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
504472005072	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
504472005073	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
504472005074	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
504472005075	active site
504472005076	Zn binding site [ion binding]; other site
504472005077	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472005078	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472005079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005080	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472005081	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472005082	active site
504472005083	catalytic tetrad [active]
504472005084	alpha-glucosidase; Provisional; Region: PRK10137
504472005085	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
504472005086	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
504472005087	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472005088	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472005089	catalytic residues [active]
504472005090	Uncharacterized conserved protein [Function unknown]; Region: COG1262
504472005091	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
504472005092	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
504472005093	BNR repeat-like domain; Region: BNR_2; pfam13088
504472005094	catalytic site [active]
504472005095	Asp-box motif; other site
504472005096	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472005097	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
504472005098	PA/protease or protease-like domain interface [polypeptide binding]; other site
504472005099	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
504472005100	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472005101	metal binding site [ion binding]; metal-binding site
504472005102	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472005103	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472005104	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
504472005105	hypothetical protein; Provisional; Region: PRK08201
504472005106	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472005107	metal binding site [ion binding]; metal-binding site
504472005108	Uncharacterized conserved protein [Function unknown]; Region: COG2353
504472005109	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472005110	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
504472005111	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
504472005112	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
504472005113	ApbE family; Region: ApbE; pfam02424
504472005114	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
504472005115	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
504472005116	iron-sulfur cluster [ion binding]; other site
504472005117	[2Fe-2S] cluster binding site [ion binding]; other site
504472005118	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472005119	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472005120	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
504472005121	PAS domain; Region: PAS; smart00091
504472005122	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472005123	putative active site [active]
504472005124	heme pocket [chemical binding]; other site
504472005125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005126	dimer interface [polypeptide binding]; other site
504472005127	phosphorylation site [posttranslational modification]
504472005128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005129	ATP binding site [chemical binding]; other site
504472005130	Mg2+ binding site [ion binding]; other site
504472005131	G-X-G motif; other site
504472005132	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
504472005133	tetramer interface [polypeptide binding]; other site
504472005134	dimer interface [polypeptide binding]; other site
504472005135	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
504472005136	tetramer interface [polypeptide binding]; other site
504472005137	dimer interface [polypeptide binding]; other site
504472005138	circadian clock protein KaiC; Reviewed; Region: PRK09302
504472005139	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
504472005140	Walker A motif; other site
504472005141	ATP binding site [chemical binding]; other site
504472005142	Walker B motif; other site
504472005143	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
504472005144	Walker A motif; other site
504472005145	ATP binding site [chemical binding]; other site
504472005146	Walker B motif; other site
504472005147	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
504472005148	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
504472005149	Galactose oxidase, central domain; Region: Kelch_3; cl02701
504472005150	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472005151	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
504472005152	protein binding site [polypeptide binding]; other site
504472005153	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
504472005154	Catalytic dyad [active]
504472005155	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472005156	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472005157	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
504472005158	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472005159	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472005160	PAS fold; Region: PAS_4; pfam08448
504472005161	PAS domain; Region: PAS_9; pfam13426
504472005162	PAS fold; Region: PAS_7; pfam12860
504472005163	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005165	dimer interface [polypeptide binding]; other site
504472005166	phosphorylation site [posttranslational modification]
504472005167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005168	ATP binding site [chemical binding]; other site
504472005169	Mg2+ binding site [ion binding]; other site
504472005170	G-X-G motif; other site
504472005171	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
504472005172	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
504472005173	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
504472005174	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
504472005175	beta-galactosidase; Region: BGL; TIGR03356
504472005176	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
504472005177	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
504472005178	maltose O-acetyltransferase; Provisional; Region: PRK10092
504472005179	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
504472005180	active site
504472005181	substrate binding site [chemical binding]; other site
504472005182	trimer interface [polypeptide binding]; other site
504472005183	CoA binding site [chemical binding]; other site
504472005184	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472005185	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472005186	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472005187	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472005188	Cytochrome c; Region: Cytochrom_C; cl11414
504472005189	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472005190	ligand binding site [chemical binding]; other site
504472005191	metal binding site [ion binding]; metal-binding site
504472005192	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472005193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005194	active site
504472005195	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005196	phosphorylation site [posttranslational modification]
504472005197	intermolecular recognition site; other site
504472005198	dimerization interface [polypeptide binding]; other site
504472005199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005200	dimer interface [polypeptide binding]; other site
504472005201	phosphorylation site [posttranslational modification]
504472005202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005203	ATP binding site [chemical binding]; other site
504472005204	Mg2+ binding site [ion binding]; other site
504472005205	G-X-G motif; other site
504472005206	Response regulator receiver domain; Region: Response_reg; pfam00072
504472005207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005208	active site
504472005209	phosphorylation site [posttranslational modification]
504472005210	intermolecular recognition site; other site
504472005211	dimerization interface [polypeptide binding]; other site
504472005212	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005214	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
504472005215	Melibiase; Region: Melibiase; pfam02065
504472005216	Isochorismatase family; Region: Isochorismatase; pfam00857
504472005217	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
504472005218	catalytic triad [active]
504472005219	conserved cis-peptide bond; other site
504472005220	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472005221	SusD family; Region: SusD; pfam07980
504472005222	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472005223	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472005224	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472005225	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
504472005226	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472005227	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472005228	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472005229	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
504472005230	aminotransferase AlaT; Validated; Region: PRK09265
504472005231	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472005232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472005233	homodimer interface [polypeptide binding]; other site
504472005234	catalytic residue [active]
504472005235	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
504472005236	replicative DNA helicase; Region: DnaB; TIGR00665
504472005237	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
504472005238	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
504472005239	Walker A motif; other site
504472005240	ATP binding site [chemical binding]; other site
504472005241	Walker B motif; other site
504472005242	DNA binding loops [nucleotide binding]
504472005243	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
504472005244	PhoH-like protein; Region: PhoH; pfam02562
504472005245	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
504472005246	active site
504472005247	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472005248	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
504472005249	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472005250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472005251	Coenzyme A binding pocket [chemical binding]; other site
504472005252	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
504472005253	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
504472005254	Competence protein; Region: Competence; pfam03772
504472005255	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472005256	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
504472005257	ABC1 family; Region: ABC1; cl17513
504472005258	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
504472005259	active site
504472005260	ATP binding site [chemical binding]; other site
504472005261	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472005262	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472005263	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472005264	glycerate kinase; Region: TIGR00045
504472005265	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
504472005266	catalytic motif [active]
504472005267	Zn binding site [ion binding]; other site
504472005268	Protein of unknown function, DUF479; Region: DUF479; cl01203
504472005269	amino acid transporter; Region: 2A0306; TIGR00909
504472005270	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
504472005271	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
504472005272	active site
504472005273	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472005274	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
504472005275	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472005276	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472005277	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
504472005278	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472005279	active site
504472005280	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472005281	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
504472005282	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472005283	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
504472005284	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472005285	N-terminal plug; other site
504472005286	ligand-binding site [chemical binding]; other site
504472005287	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
504472005288	DNA-binding site [nucleotide binding]; DNA binding site
504472005289	RNA-binding motif; other site
504472005290	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472005291	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472005292	TIR domain; Region: TIR_2; pfam13676
504472005293	Transcriptional regulator [Transcription]; Region: LysR; COG0583
504472005294	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472005295	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
504472005296	dimerization interface [polypeptide binding]; other site
504472005297	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472005298	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
504472005299	substrate binding pocket [chemical binding]; other site
504472005300	catalytic triad [active]
504472005301	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
504472005302	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
504472005303	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472005304	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472005305	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005306	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
504472005307	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472005308	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472005309	maltose O-acetyltransferase; Provisional; Region: PRK10092
504472005310	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
504472005311	active site
504472005312	substrate binding site [chemical binding]; other site
504472005313	trimer interface [polypeptide binding]; other site
504472005314	CoA binding site [chemical binding]; other site
504472005315	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
504472005316	integron integrase; Region: integrase_gron; TIGR02249
504472005317	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472005318	active site
504472005319	Int/Topo IB signature motif; other site
504472005320	DNA binding site [nucleotide binding]
504472005321	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472005322	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472005323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472005324	Coenzyme A binding pocket [chemical binding]; other site
504472005325	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
504472005326	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
504472005327	Methyltransferase domain; Region: Methyltransf_26; pfam13659
504472005328	DEAD-like helicases superfamily; Region: DEXDc; smart00487
504472005329	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472005330	ATP binding site [chemical binding]; other site
504472005331	putative Mg++ binding site [ion binding]; other site
504472005332	Pseudomurein-binding repeat; Region: PMBR; pfam09373
504472005333	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
504472005334	T5orf172 domain; Region: T5orf172; pfam10544
504472005335	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
504472005336	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
504472005337	active site
504472005338	Int/Topo IB signature motif; other site
504472005339	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
504472005340	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472005341	CHC2 zinc finger; Region: zf-CHC2; cl17510
504472005342	Toprim-like; Region: Toprim_2; pfam13155
504472005343	active site
504472005344	metal binding site [ion binding]; metal-binding site
504472005345	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
504472005346	MPN+ (JAMM) motif; other site
504472005347	Zinc-binding site [ion binding]; other site
504472005348	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
504472005349	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
504472005350	Betaherpesvirus UL82/83 protein N terminus; Region: Herpes_UL82_83; pfam05784
504472005351	TrwC relaxase; Region: TrwC; pfam08751
504472005352	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
504472005353	AAA domain; Region: AAA_30; pfam13604
504472005354	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472005355	Family description; Region: UvrD_C_2; pfam13538
504472005356	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
504472005357	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
504472005358	Catalytic site [active]
504472005359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
504472005360	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
504472005361	hydrophobic ligand binding site; other site
504472005362	Predicted permeases [General function prediction only]; Region: COG0795
504472005363	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
504472005364	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
504472005365	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
504472005366	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
504472005367	16S/18S rRNA binding site [nucleotide binding]; other site
504472005368	S13e-L30e interaction site [polypeptide binding]; other site
504472005369	25S rRNA binding site [nucleotide binding]; other site
504472005370	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
504472005371	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
504472005372	RNase E interface [polypeptide binding]; other site
504472005373	trimer interface [polypeptide binding]; other site
504472005374	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
504472005375	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
504472005376	RNase E interface [polypeptide binding]; other site
504472005377	trimer interface [polypeptide binding]; other site
504472005378	active site
504472005379	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
504472005380	putative nucleic acid binding region [nucleotide binding]; other site
504472005381	G-X-X-G motif; other site
504472005382	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
504472005383	RNA binding site [nucleotide binding]; other site
504472005384	domain interface; other site
504472005385	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
504472005386	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
504472005387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472005388	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
504472005389	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472005390	DNA binding residues [nucleotide binding]
504472005391	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
504472005392	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
504472005393	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
504472005394	PAS domain; Region: PAS_9; pfam13426
504472005395	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005396	putative active site [active]
504472005397	heme pocket [chemical binding]; other site
504472005398	PAS fold; Region: PAS_4; pfam08448
504472005399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005400	putative active site [active]
504472005401	heme pocket [chemical binding]; other site
504472005402	TPR repeat; Region: TPR_11; pfam13414
504472005403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005404	binding surface
504472005405	TPR motif; other site
504472005406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005407	TPR motif; other site
504472005408	binding surface
504472005409	TPR repeat; Region: TPR_11; pfam13414
504472005410	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
504472005411	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
504472005412	dimer interface [polypeptide binding]; other site
504472005413	tetramer interface [polypeptide binding]; other site
504472005414	PYR/PP interface [polypeptide binding]; other site
504472005415	TPP binding site [chemical binding]; other site
504472005416	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
504472005417	TPP-binding site; other site
504472005418	Response regulator receiver domain; Region: Response_reg; pfam00072
504472005419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005420	active site
504472005421	phosphorylation site [posttranslational modification]
504472005422	intermolecular recognition site; other site
504472005423	dimerization interface [polypeptide binding]; other site
504472005424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005426	dimer interface [polypeptide binding]; other site
504472005427	phosphorylation site [posttranslational modification]
504472005428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005429	ATP binding site [chemical binding]; other site
504472005430	Mg2+ binding site [ion binding]; other site
504472005431	G-X-G motif; other site
504472005432	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
504472005433	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472005434	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472005435	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472005436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472005437	S-adenosylmethionine binding site [chemical binding]; other site
504472005438	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
504472005439	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
504472005440	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
504472005441	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
504472005442	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
504472005443	active site
504472005444	substrate binding site [chemical binding]; other site
504472005445	trimer interface [polypeptide binding]; other site
504472005446	CoA binding site [chemical binding]; other site
504472005447	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472005448	non-specific DNA binding site [nucleotide binding]; other site
504472005449	salt bridge; other site
504472005450	sequence-specific DNA binding site [nucleotide binding]; other site
504472005451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005452	binding surface
504472005453	TPR motif; other site
504472005454	DNA gyrase subunit A; Validated; Region: PRK05560
504472005455	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
504472005456	CAP-like domain; other site
504472005457	active site
504472005458	primary dimer interface [polypeptide binding]; other site
504472005459	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
504472005460	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
504472005461	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
504472005462	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
504472005463	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
504472005464	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
504472005465	RES domain; Region: RES; pfam08808
504472005466	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472005467	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472005468	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
504472005469	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
504472005470	active site
504472005471	metal-binding site [ion binding]
504472005472	nucleotide-binding site [chemical binding]; other site
504472005473	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
504472005474	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
504472005475	dimer interface [polypeptide binding]; other site
504472005476	motif 1; other site
504472005477	active site
504472005478	motif 2; other site
504472005479	motif 3; other site
504472005480	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
504472005481	anticodon binding site; other site
504472005482	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472005483	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472005484	active site
504472005485	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
504472005486	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
504472005487	inhibitor-cofactor binding pocket; inhibition site
504472005488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472005489	catalytic residue [active]
504472005490	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
504472005491	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
504472005492	ligand binding site [chemical binding]; other site
504472005493	membrane protein insertase; Provisional; Region: PRK01318
504472005494	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
504472005495	CTP synthetase; Validated; Region: pyrG; PRK05380
504472005496	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
504472005497	Catalytic site [active]
504472005498	active site
504472005499	UTP binding site [chemical binding]; other site
504472005500	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
504472005501	active site
504472005502	putative oxyanion hole; other site
504472005503	catalytic triad [active]
504472005504	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472005505	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472005506	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472005507	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
504472005508	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
504472005509	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
504472005510	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472005511	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
504472005512	active site
504472005513	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472005514	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472005515	sequence-specific DNA binding site [nucleotide binding]; other site
504472005516	salt bridge; other site
504472005517	Domain of unknown function (DUF955); Region: DUF955; pfam06114
504472005518	benzoate transport; Region: 2A0115; TIGR00895
504472005519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472005520	putative substrate translocation pore; other site
504472005521	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
504472005522	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472005523	Coenzyme A binding pocket [chemical binding]; other site
504472005524	aconitate hydratase; Validated; Region: PRK07229
504472005525	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
504472005526	substrate binding site [chemical binding]; other site
504472005527	ligand binding site [chemical binding]; other site
504472005528	Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578
504472005529	substrate binding site [chemical binding]; other site
504472005530	CHRD domain; Region: CHRD; pfam07452
504472005531	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
504472005532	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
504472005533	putative dimer interface [polypeptide binding]; other site
504472005534	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
504472005535	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
504472005536	active site
504472005537	interdomain interaction site; other site
504472005538	putative metal-binding site [ion binding]; other site
504472005539	nucleotide binding site [chemical binding]; other site
504472005540	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
504472005541	domain I; other site
504472005542	DNA binding groove [nucleotide binding]
504472005543	phosphate binding site [ion binding]; other site
504472005544	domain II; other site
504472005545	domain III; other site
504472005546	nucleotide binding site [chemical binding]; other site
504472005547	catalytic site [active]
504472005548	domain IV; other site
504472005549	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
504472005550	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
504472005551	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
504472005552	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
504472005553	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472005554	active site
504472005555	Fn3 associated; Region: Fn3_assoc; pfam13287
504472005556	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472005557	NAD-dependent deacetylase; Provisional; Region: PRK00481
504472005558	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
504472005559	NAD+ binding site [chemical binding]; other site
504472005560	substrate binding site [chemical binding]; other site
504472005561	Zn binding site [ion binding]; other site
504472005562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
504472005563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
504472005564	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
504472005565	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
504472005566	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
504472005567	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
504472005568	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005569	binding surface
504472005570	TPR motif; other site
504472005571	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
504472005572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005573	binding surface
504472005574	TPR motif; other site
504472005575	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
504472005576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005577	binding surface
504472005578	TPR motif; other site
504472005579	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
504472005580	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
504472005581	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472005582	Sporulation related domain; Region: SPOR; pfam05036
504472005583	acetyl-CoA synthetase; Provisional; Region: PRK00174
504472005584	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
504472005585	active site
504472005586	CoA binding site [chemical binding]; other site
504472005587	acyl-activating enzyme (AAE) consensus motif; other site
504472005588	AMP binding site [chemical binding]; other site
504472005589	acetate binding site [chemical binding]; other site
504472005590	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
504472005591	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
504472005592	acyl-activating enzyme (AAE) consensus motif; other site
504472005593	AMP binding site [chemical binding]; other site
504472005594	active site
504472005595	CoA binding site [chemical binding]; other site
504472005596	Response regulator receiver domain; Region: Response_reg; pfam00072
504472005597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005598	active site
504472005599	phosphorylation site [posttranslational modification]
504472005600	intermolecular recognition site; other site
504472005601	dimerization interface [polypeptide binding]; other site
504472005602	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
504472005603	Na binding site [ion binding]; other site
504472005604	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005605	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005606	dimer interface [polypeptide binding]; other site
504472005607	phosphorylation site [posttranslational modification]
504472005608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005609	ATP binding site [chemical binding]; other site
504472005610	Mg2+ binding site [ion binding]; other site
504472005611	G-X-G motif; other site
504472005612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472005613	putative substrate translocation pore; other site
504472005614	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
504472005615	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
504472005616	Helix-turn-helix domain; Region: HTH_28; pfam13518
504472005617	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
504472005618	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
504472005619	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
504472005620	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
504472005621	active site
504472005622	SAM binding site [chemical binding]; other site
504472005623	homodimer interface [polypeptide binding]; other site
504472005624	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472005625	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472005626	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472005627	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
504472005628	NADP binding site [chemical binding]; other site
504472005629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005630	active site
504472005631	phosphorylation site [posttranslational modification]
504472005632	intermolecular recognition site; other site
504472005633	dimerization interface [polypeptide binding]; other site
504472005634	CHASE3 domain; Region: CHASE3; pfam05227
504472005635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005636	dimer interface [polypeptide binding]; other site
504472005637	phosphorylation site [posttranslational modification]
504472005638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005639	ATP binding site [chemical binding]; other site
504472005640	G-X-G motif; other site
504472005641	Predicted membrane protein [Function unknown]; Region: COG2311
504472005642	Protein of unknown function (DUF418); Region: DUF418; cl12135
504472005643	Protein of unknown function (DUF418); Region: DUF418; pfam04235
504472005644	LytTr DNA-binding domain; Region: LytTR; smart00850
504472005645	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472005646	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472005647	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
504472005648	DNA binding residues [nucleotide binding]
504472005649	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472005650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005651	Response regulator receiver domain; Region: Response_reg; pfam00072
504472005652	active site
504472005653	phosphorylation site [posttranslational modification]
504472005654	intermolecular recognition site; other site
504472005655	dimerization interface [polypeptide binding]; other site
504472005656	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472005657	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472005658	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472005659	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472005660	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
504472005661	dimer interface [polypeptide binding]; other site
504472005662	FMN binding site [chemical binding]; other site
504472005663	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
504472005664	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472005665	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005666	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472005667	FtsX-like permease family; Region: FtsX; pfam02687
504472005668	FtsX-like permease family; Region: FtsX; pfam02687
504472005669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
504472005671	dimer interface [polypeptide binding]; other site
504472005672	phosphorylation site [posttranslational modification]
504472005673	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
504472005674	active site
504472005675	ATP binding site [chemical binding]; other site
504472005676	substrate binding site [chemical binding]; other site
504472005677	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
504472005678	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
504472005679	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
504472005680	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
504472005681	active site
504472005682	substrate binding site [chemical binding]; other site
504472005683	Mg2+ binding site [ion binding]; other site
504472005684	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
504472005685	active site triad [active]
504472005686	Histidine kinase; Region: His_kinase; pfam06580
504472005687	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472005688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005689	active site
504472005690	phosphorylation site [posttranslational modification]
504472005691	intermolecular recognition site; other site
504472005692	dimerization interface [polypeptide binding]; other site
504472005693	LytTr DNA-binding domain; Region: LytTR; smart00850
504472005694	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472005695	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472005696	ligand binding site [chemical binding]; other site
504472005697	flexible hinge region; other site
504472005698	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472005699	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472005700	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472005701	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472005702	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472005703	SusD family; Region: SusD; pfam07980
504472005704	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472005705	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472005706	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472005707	SusD family; Region: SusD; pfam07980
504472005708	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
504472005709	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
504472005710	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
504472005711	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
504472005712	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472005713	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472005714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005716	dimer interface [polypeptide binding]; other site
504472005717	phosphorylation site [posttranslational modification]
504472005718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005719	ATP binding site [chemical binding]; other site
504472005720	Mg2+ binding site [ion binding]; other site
504472005721	G-X-G motif; other site
504472005722	Response regulator receiver domain; Region: Response_reg; pfam00072
504472005723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005724	active site
504472005725	phosphorylation site [posttranslational modification]
504472005726	intermolecular recognition site; other site
504472005727	dimerization interface [polypeptide binding]; other site
504472005728	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005729	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
504472005730	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472005731	active site
504472005732	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472005733	ligand binding site [chemical binding]; other site
504472005734	metal binding site [ion binding]; metal-binding site
504472005735	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472005736	Putative esterase; Region: Esterase; pfam00756
504472005737	TPR repeat; Region: TPR_11; pfam13414
504472005738	glucose-1-dehydrogenase; Provisional; Region: PRK08936
504472005739	classical (c) SDRs; Region: SDR_c; cd05233
504472005740	NAD(P) binding site [chemical binding]; other site
504472005741	active site
504472005742	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472005743	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005745	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
504472005746	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
504472005747	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472005748	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472005749	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005750	hypothetical protein; Validated; Region: PRK05868
504472005751	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
504472005752	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472005753	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472005754	RES domain; Region: RES; cl02411
504472005755	RES domain; Region: RES; smart00953
504472005756	transposase/IS protein; Provisional; Region: PRK09183
504472005757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472005758	Walker A motif; other site
504472005759	ATP binding site [chemical binding]; other site
504472005760	Walker B motif; other site
504472005761	arginine finger; other site
504472005762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472005763	Integrase core domain; Region: rve; pfam00665
504472005764	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472005765	active site
504472005766	oxyanion hole [active]
504472005767	catalytic triad [active]
504472005768	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472005769	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
504472005770	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472005771	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472005772	DNA binding residues [nucleotide binding]
504472005773	dimerization interface [polypeptide binding]; other site
504472005774	Spi protease inhibitor; Region: Inhibitor_I69; pfam13734
504472005775	Peptidase C10 family; Region: Peptidase_C10; pfam01640
504472005776	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
504472005777	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
504472005778	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
504472005779	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472005780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005781	active site
504472005782	phosphorylation site [posttranslational modification]
504472005783	intermolecular recognition site; other site
504472005784	dimerization interface [polypeptide binding]; other site
504472005785	LytTr DNA-binding domain; Region: LytTR; pfam04397
504472005786	Histidine kinase; Region: His_kinase; pfam06580
504472005787	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472005788	GAF domain; Region: GAF; pfam01590
504472005789	PAS domain S-box; Region: sensory_box; TIGR00229
504472005790	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472005791	GAF domain; Region: GAF; pfam01590
504472005792	PAS domain S-box; Region: sensory_box; TIGR00229
504472005793	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472005794	GAF domain; Region: GAF; pfam01590
504472005795	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472005796	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
504472005797	Coenzyme A binding pocket [chemical binding]; other site
504472005798	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472005799	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472005800	RES domain; Region: RES; pfam08808
504472005801	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005802	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472005803	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472005804	TPR repeat; Region: TPR_11; pfam13414
504472005805	binding surface
504472005806	TPR motif; other site
504472005807	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472005808	TAP-like protein; Region: Abhydrolase_4; pfam08386
504472005809	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472005810	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
504472005811	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
504472005812	hypothetical protein; Provisional; Region: PRK07236
504472005813	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
504472005814	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005815	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005816	Fic family protein [Function unknown]; Region: COG3177
504472005817	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
504472005818	Fic/DOC family; Region: Fic; pfam02661
504472005819	transposase/IS protein; Provisional; Region: PRK09183
504472005820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472005821	Walker A motif; other site
504472005822	ATP binding site [chemical binding]; other site
504472005823	Walker B motif; other site
504472005824	arginine finger; other site
504472005825	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472005826	Integrase core domain; Region: rve; pfam00665
504472005827	Two component regulator propeller; Region: Reg_prop; pfam07494
504472005828	YceI-like domain; Region: YceI; pfam04264
504472005829	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472005830	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005831	FtsX-like permease family; Region: FtsX; pfam02687
504472005832	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005833	FtsX-like permease family; Region: FtsX; pfam02687
504472005834	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472005835	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472005836	active site
504472005837	catalytic triad [active]
504472005838	oxyanion hole [active]
504472005839	CAAX protease self-immunity; Region: Abi; pfam02517
504472005840	Predicted peptidase [General function prediction only]; Region: COG4099
504472005841	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472005842	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
504472005843	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
504472005844	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472005845	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005846	putative active site [active]
504472005847	heme pocket [chemical binding]; other site
504472005848	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005849	heme pocket [chemical binding]; other site
504472005850	putative active site [active]
504472005851	PAS domain; Region: PAS_8; pfam13188
504472005852	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472005853	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472005854	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005855	dimer interface [polypeptide binding]; other site
504472005856	phosphorylation site [posttranslational modification]
504472005857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005858	ATP binding site [chemical binding]; other site
504472005859	Mg2+ binding site [ion binding]; other site
504472005860	G-X-G motif; other site
504472005861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005862	Response regulator receiver domain; Region: Response_reg; pfam00072
504472005863	active site
504472005864	phosphorylation site [posttranslational modification]
504472005865	intermolecular recognition site; other site
504472005866	dimerization interface [polypeptide binding]; other site
504472005867	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472005868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472005869	active site
504472005870	phosphorylation site [posttranslational modification]
504472005871	intermolecular recognition site; other site
504472005872	dimerization interface [polypeptide binding]; other site
504472005873	GAF domain; Region: GAF; pfam01590
504472005874	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472005875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005877	ATP binding site [chemical binding]; other site
504472005878	Mg2+ binding site [ion binding]; other site
504472005879	G-X-G motif; other site
504472005880	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
504472005881	PAS fold; Region: PAS_4; pfam08448
504472005882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005883	dimer interface [polypeptide binding]; other site
504472005884	phosphorylation site [posttranslational modification]
504472005885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005886	ATP binding site [chemical binding]; other site
504472005887	Mg2+ binding site [ion binding]; other site
504472005888	G-X-G motif; other site
504472005889	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472005890	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472005891	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005892	FtsX-like permease family; Region: FtsX; pfam02687
504472005893	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005894	FtsX-like permease family; Region: FtsX; pfam02687
504472005895	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472005896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005897	Uncharacterized conserved protein [Function unknown]; Region: COG4925
504472005898	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
504472005899	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472005900	catalytic loop [active]
504472005901	iron binding site [ion binding]; other site
504472005902	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472005903	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
504472005904	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
504472005905	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472005906	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472005907	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472005908	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472005909	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
504472005910	substrate binding pocket [chemical binding]; other site
504472005911	catalytic triad [active]
504472005912	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
504472005913	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472005914	NAD(P) binding site [chemical binding]; other site
504472005915	active site
504472005916	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
504472005917	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472005918	catalytic loop [active]
504472005919	iron binding site [ion binding]; other site
504472005920	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472005921	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
504472005922	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
504472005923	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472005924	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472005925	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472005926	short chain dehydrogenase; Provisional; Region: PRK06172
504472005927	classical (c) SDRs; Region: SDR_c; cd05233
504472005928	NAD(P) binding site [chemical binding]; other site
504472005929	active site
504472005930	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472005931	maltose O-acetyltransferase; Provisional; Region: PRK10092
504472005932	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
504472005933	trimer interface [polypeptide binding]; other site
504472005934	active site
504472005935	substrate binding site [chemical binding]; other site
504472005936	CoA binding site [chemical binding]; other site
504472005937	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472005938	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472005939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472005940	S-adenosylmethionine binding site [chemical binding]; other site
504472005941	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472005942	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472005943	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005944	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005945	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005946	putative active site [active]
504472005947	PAS fold; Region: PAS_3; pfam08447
504472005948	heme pocket [chemical binding]; other site
504472005949	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472005950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005951	putative active site [active]
504472005952	heme pocket [chemical binding]; other site
504472005953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472005954	putative active site [active]
504472005955	heme pocket [chemical binding]; other site
504472005956	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472005957	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472005958	dimer interface [polypeptide binding]; other site
504472005959	phosphorylation site [posttranslational modification]
504472005960	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472005961	ATP binding site [chemical binding]; other site
504472005962	G-X-G motif; other site
504472005963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
504472005964	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
504472005965	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
504472005966	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472005967	Walker A/P-loop; other site
504472005968	ATP binding site [chemical binding]; other site
504472005969	Q-loop/lid; other site
504472005970	ABC transporter signature motif; other site
504472005971	Walker B; other site
504472005972	D-loop; other site
504472005973	H-loop/switch region; other site
504472005974	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472005975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472005976	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472005977	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472005978	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472005979	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005980	FtsX-like permease family; Region: FtsX; pfam02687
504472005981	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472005982	FtsX-like permease family; Region: FtsX; pfam02687
504472005983	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472005984	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472005985	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472005986	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472005987	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472005988	active site
504472005989	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
504472005990	CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081
504472005991	putative catalytic site [active]
504472005992	CdtC interface [polypeptide binding]; other site
504472005993	heterotrimer interface [polypeptide binding]; other site
504472005994	CdtA interface [polypeptide binding]; other site
504472005995	putative metal binding site [ion binding]; other site
504472005996	putative phosphate binding site [ion binding]; other site
504472005997	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
504472005998	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
504472005999	nucleotide binding site [chemical binding]; other site
504472006000	NEF interaction site [polypeptide binding]; other site
504472006001	SBD interface [polypeptide binding]; other site
504472006002	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
504472006003	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
504472006004	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
504472006005	23S rRNA binding site [nucleotide binding]; other site
504472006006	L21 binding site [polypeptide binding]; other site
504472006007	L13 binding site [polypeptide binding]; other site
504472006008	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
504472006009	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
504472006010	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
504472006011	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
504472006012	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
504472006013	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
504472006014	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
504472006015	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
504472006016	active site
504472006017	dimer interface [polypeptide binding]; other site
504472006018	motif 1; other site
504472006019	motif 2; other site
504472006020	motif 3; other site
504472006021	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
504472006022	anticodon binding site; other site
504472006023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472006024	binding surface
504472006025	TPR motif; other site
504472006026	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006027	TPR repeat; Region: TPR_11; pfam13414
504472006028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472006029	binding surface
504472006030	TPR repeat; Region: TPR_11; pfam13414
504472006031	TPR motif; other site
504472006032	TPR repeat; Region: TPR_11; pfam13414
504472006033	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472006034	binding surface
504472006035	TPR motif; other site
504472006036	TPR repeat; Region: TPR_11; pfam13414
504472006037	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
504472006038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472006039	S-adenosylmethionine binding site [chemical binding]; other site
504472006040	EVE domain; Region: EVE; pfam01878
504472006041	DinB superfamily; Region: DinB_2; pfam12867
504472006042	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
504472006043	putative active site [active]
504472006044	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
504472006045	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
504472006046	CAP-like domain; other site
504472006047	active site
504472006048	primary dimer interface [polypeptide binding]; other site
504472006049	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
504472006050	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
504472006051	NAD binding site [chemical binding]; other site
504472006052	ligand binding site [chemical binding]; other site
504472006053	catalytic site [active]
504472006054	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
504472006055	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
504472006056	Predicted methyltransferases [General function prediction only]; Region: COG0313
504472006057	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
504472006058	putative SAM binding site [chemical binding]; other site
504472006059	putative homodimer interface [polypeptide binding]; other site
504472006060	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
504472006061	aromatic arch; other site
504472006062	DCoH dimer interaction site [polypeptide binding]; other site
504472006063	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
504472006064	DCoH tetramer interaction site [polypeptide binding]; other site
504472006065	substrate binding site [chemical binding]; other site
504472006066	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
504472006067	active site
504472006068	homodimer interface [polypeptide binding]; other site
504472006069	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
504472006070	active site
504472006071	short chain dehydrogenase; Provisional; Region: PRK06179
504472006072	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472006073	NADP binding site [chemical binding]; other site
504472006074	active site
504472006075	steroid binding site; other site
504472006076	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472006077	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472006078	active site
504472006079	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
504472006080	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
504472006081	NodB motif; other site
504472006082	active site
504472006083	catalytic site [active]
504472006084	metal binding site [ion binding]; metal-binding site
504472006085	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472006086	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192
504472006087	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
504472006088	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
504472006089	active site
504472006090	putative DNA-binding cleft [nucleotide binding]; other site
504472006091	dimer interface [polypeptide binding]; other site
504472006092	Histidine kinase; Region: His_kinase; pfam06580
504472006093	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472006094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472006095	active site
504472006096	phosphorylation site [posttranslational modification]
504472006097	intermolecular recognition site; other site
504472006098	dimerization interface [polypeptide binding]; other site
504472006099	LytTr DNA-binding domain; Region: LytTR; smart00850
504472006100	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
504472006101	putative active site [active]
504472006102	Pirin-related protein [General function prediction only]; Region: COG1741
504472006103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
504472006104	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
504472006105	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
504472006106	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
504472006107	catalytic residues [active]
504472006108	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472006109	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472006110	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472006111	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
504472006112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472006113	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
504472006114	PAS domain; Region: PAS_9; pfam13426
504472006115	PAS fold; Region: PAS_4; pfam08448
504472006116	PAS domain; Region: PAS_9; pfam13426
504472006117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472006118	putative active site [active]
504472006119	heme pocket [chemical binding]; other site
504472006120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472006121	dimer interface [polypeptide binding]; other site
504472006122	phosphorylation site [posttranslational modification]
504472006123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472006124	ATP binding site [chemical binding]; other site
504472006125	Mg2+ binding site [ion binding]; other site
504472006126	G-X-G motif; other site
504472006127	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006128	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
504472006130	Histidine kinase; Region: HisKA_2; pfam07568
504472006131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472006132	ATP binding site [chemical binding]; other site
504472006133	Mg2+ binding site [ion binding]; other site
504472006134	G-X-G motif; other site
504472006135	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
504472006136	B12 binding site [chemical binding]; other site
504472006137	cobalt ligand [ion binding]; other site
504472006138	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
504472006139	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472006140	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
504472006141	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
504472006142	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
504472006143	active site
504472006144	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
504472006145	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
504472006146	Methyltransferase domain; Region: Methyltransf_26; pfam13659
504472006147	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
504472006148	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
504472006149	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
504472006150	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472006151	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
504472006152	active site
504472006153	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
504472006154	dimer interface [polypeptide binding]; other site
504472006155	substrate binding site [chemical binding]; other site
504472006156	catalytic residues [active]
504472006157	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
504472006158	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
504472006159	oligomer interface [polypeptide binding]; other site
504472006160	metal binding site [ion binding]; metal-binding site
504472006161	metal binding site [ion binding]; metal-binding site
504472006162	Cl binding site [ion binding]; other site
504472006163	aspartate ring; other site
504472006164	basic sphincter; other site
504472006165	putative hydrophobic gate; other site
504472006166	periplasmic entrance; other site
504472006167	Glyco_18 domain; Region: Glyco_18; smart00636
504472006168	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
504472006169	active site
504472006170	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
504472006171	endonuclease III; Region: ENDO3c; smart00478
504472006172	minor groove reading motif; other site
504472006173	helix-hairpin-helix signature motif; other site
504472006174	substrate binding pocket [chemical binding]; other site
504472006175	active site
504472006176	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
504472006177	metal-dependent hydrolase; Provisional; Region: PRK13291
504472006178	DinB superfamily; Region: DinB_2; pfam12867
504472006179	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
504472006180	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
504472006181	active site
504472006182	dimerization interface [polypeptide binding]; other site
504472006183	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
504472006184	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
504472006185	dimerization interface [polypeptide binding]; other site
504472006186	ATP binding site [chemical binding]; other site
504472006187	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
504472006188	dimerization interface [polypeptide binding]; other site
504472006189	ATP binding site [chemical binding]; other site
504472006190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
504472006191	HTH-like domain; Region: HTH_21; pfam13276
504472006192	Integrase core domain; Region: rve; pfam00665
504472006193	Integrase core domain; Region: rve_3; pfam13683
504472006194	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472006195	DNA-binding interface [nucleotide binding]; DNA binding site
504472006196	Winged helix-turn helix; Region: HTH_29; pfam13551
504472006197	Transposase; Region: HTH_Tnp_1; pfam01527
504472006198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
504472006199	Helix-turn-helix domain; Region: HTH_28; pfam13518
504472006200	Winged helix-turn helix; Region: HTH_29; pfam13551
504472006201	Homeodomain-like domain; Region: HTH_32; pfam13565
504472006202	Integrase core domain; Region: rve; pfam00665
504472006203	Integrase core domain; Region: rve_3; pfam13683
504472006204	Helix-turn-helix domain; Region: HTH_28; pfam13518
504472006205	Winged helix-turn helix; Region: HTH_29; pfam13551
504472006206	Homeodomain-like domain; Region: HTH_32; pfam13565
504472006207	Integrase core domain; Region: rve; pfam00665
504472006208	Integrase core domain; Region: rve_3; pfam13683
504472006209	Transposase; Region: HTH_Tnp_1; pfam01527
504472006210	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
504472006211	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472006212	DNA-binding interface [nucleotide binding]; DNA binding site
504472006213	Winged helix-turn helix; Region: HTH_29; pfam13551
504472006214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
504472006215	HTH-like domain; Region: HTH_21; pfam13276
504472006216	Integrase core domain; Region: rve; pfam00665
504472006217	Integrase core domain; Region: rve_3; pfam13683
504472006218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472006219	D-galactonate transporter; Region: 2A0114; TIGR00893
504472006220	putative substrate translocation pore; other site
504472006221	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472006222	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
504472006223	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
504472006224	Divergent AAA domain; Region: AAA_4; pfam04326
504472006225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472006226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472006227	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
504472006228	SdpI/YhfL protein family; Region: SdpI; pfam13630
504472006229	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472006230	dimerization interface [polypeptide binding]; other site
504472006231	putative DNA binding site [nucleotide binding]; other site
504472006232	putative Zn2+ binding site [ion binding]; other site
504472006233	alpha-glucosidase; Provisional; Region: PRK10137
504472006234	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
504472006235	glucose-1-dehydrogenase; Provisional; Region: PRK08936
504472006236	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
504472006237	NAD binding site [chemical binding]; other site
504472006238	homodimer interface [polypeptide binding]; other site
504472006239	active site
504472006240	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
504472006241	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472006242	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
504472006243	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
504472006244	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472006245	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472006246	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
504472006247	prolyl-tRNA synthetase; Provisional; Region: PRK08661
504472006248	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
504472006249	dimer interface [polypeptide binding]; other site
504472006250	motif 1; other site
504472006251	active site
504472006252	motif 2; other site
504472006253	motif 3; other site
504472006254	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
504472006255	anticodon binding site; other site
504472006256	zinc-binding site [ion binding]; other site
504472006257	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
504472006258	AAA domain; Region: AAA_18; pfam13238
504472006259	ADP binding site [chemical binding]; other site
504472006260	magnesium binding site [ion binding]; other site
504472006261	putative shikimate binding site; other site
504472006262	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
504472006263	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
504472006264	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
504472006265	dihydropteroate synthase; Region: DHPS; TIGR01496
504472006266	substrate binding pocket [chemical binding]; other site
504472006267	dimer interface [polypeptide binding]; other site
504472006268	inhibitor binding site; inhibition site
504472006269	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472006270	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472006271	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
504472006272	active site
504472006273	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
504472006274	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
504472006275	active site
504472006276	dimer interface [polypeptide binding]; other site
504472006277	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
504472006278	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
504472006279	active site
504472006280	FMN binding site [chemical binding]; other site
504472006281	substrate binding site [chemical binding]; other site
504472006282	3Fe-4S cluster binding site [ion binding]; other site
504472006283	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
504472006284	domain interface; other site
504472006285	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
504472006286	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
504472006287	Catalytic domain of Protein Kinases; Region: PKc; cd00180
504472006288	active site
504472006289	ATP binding site [chemical binding]; other site
504472006290	substrate binding site [chemical binding]; other site
504472006291	activation loop (A-loop); other site
504472006292	Homeodomain-like domain; Region: HTH_23; pfam13384
504472006293	Winged helix-turn helix; Region: HTH_29; pfam13551
504472006294	Homeodomain-like domain; Region: HTH_32; pfam13565
504472006295	Winged helix-turn helix; Region: HTH_33; pfam13592
504472006296	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472006297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472006298	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
504472006299	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472006300	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
504472006301	hypothetical protein; Provisional; Region: PRK07236
504472006302	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
504472006303	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
504472006304	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472006305	Coenzyme A binding pocket [chemical binding]; other site
504472006306	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472006307	active site
504472006308	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
504472006309	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
504472006310	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472006311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472006312	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
504472006313	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
504472006314	NAD(P) binding site [chemical binding]; other site
504472006315	catalytic residues [active]
504472006316	EthD domain; Region: EthD; cl17553
504472006317	Protein of unknown function (DUF779); Region: DUF779; pfam05610
504472006318	DoxX; Region: DoxX; pfam07681
504472006319	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
504472006320	RES domain; Region: RES; pfam08808
504472006321	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472006322	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
504472006323	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472006324	Walker A/P-loop; other site
504472006325	ATP binding site [chemical binding]; other site
504472006326	Q-loop/lid; other site
504472006327	ABC transporter signature motif; other site
504472006328	Walker B; other site
504472006329	D-loop; other site
504472006330	H-loop/switch region; other site
504472006331	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
504472006332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
504472006333	dimer interface [polypeptide binding]; other site
504472006334	conserved gate region; other site
504472006335	putative PBP binding loops; other site
504472006336	ABC-ATPase subunit interface; other site
504472006337	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
504472006338	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
504472006339	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
504472006340	Moco binding site; other site
504472006341	HAMP domain; Region: HAMP; pfam00672
504472006342	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472006343	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472006344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472006345	ATP binding site [chemical binding]; other site
504472006346	Mg2+ binding site [ion binding]; other site
504472006347	G-X-G motif; other site
504472006348	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
504472006349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472006350	active site
504472006351	phosphorylation site [posttranslational modification]
504472006352	intermolecular recognition site; other site
504472006353	dimerization interface [polypeptide binding]; other site
504472006354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472006355	Walker A motif; other site
504472006356	ATP binding site [chemical binding]; other site
504472006357	Walker B motif; other site
504472006358	arginine finger; other site
504472006359	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
504472006360	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472006361	FtsX-like permease family; Region: FtsX; pfam02687
504472006362	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472006363	FtsX-like permease family; Region: FtsX; pfam02687
504472006364	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472006365	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472006366	Walker A/P-loop; other site
504472006367	ATP binding site [chemical binding]; other site
504472006368	Q-loop/lid; other site
504472006369	ABC transporter signature motif; other site
504472006370	Walker B; other site
504472006371	D-loop; other site
504472006372	H-loop/switch region; other site
504472006373	Outer membrane efflux protein; Region: OEP; pfam02321
504472006374	Outer membrane efflux protein; Region: OEP; pfam02321
504472006375	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
504472006376	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472006377	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
504472006378	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
504472006379	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
504472006380	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
504472006381	NAD(P) binding site [chemical binding]; other site
504472006382	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472006383	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472006384	DNA binding site [nucleotide binding]
504472006385	Uncharacterized conserved protein [Function unknown]; Region: COG3777
504472006386	hypothetical protein; Provisional; Region: PRK02487
504472006387	Pirin-related protein [General function prediction only]; Region: COG1741
504472006388	Pirin; Region: Pirin; pfam02678
504472006389	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
504472006390	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
504472006391	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472006392	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472006393	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472006394	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472006395	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
504472006396	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472006397	active site
504472006398	HIGH motif; other site
504472006399	nucleotide binding site [chemical binding]; other site
504472006400	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
504472006401	KMSKS motif; other site
504472006402	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
504472006403	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472006404	catalytic residues [active]
504472006405	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
504472006406	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
504472006407	putative active site [active]
504472006408	Zn binding site [ion binding]; other site
504472006409	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472006410	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472006411	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472006412	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472006413	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472006414	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
504472006415	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
504472006416	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
504472006417	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472006418	catalytic loop [active]
504472006419	iron binding site [ion binding]; other site
504472006420	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472006421	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
504472006422	Secretin and TonB N terminus short domain; Region: STN; pfam07660
504472006423	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006424	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472006425	FecR protein; Region: FecR; pfam04773
504472006426	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472006427	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472006428	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472006429	DNA binding residues [nucleotide binding]
504472006430	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472006431	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472006432	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
504472006433	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
504472006434	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
504472006435	motif 1; other site
504472006436	active site
504472006437	motif 2; other site
504472006438	motif 3; other site
504472006439	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
504472006440	DHHA1 domain; Region: DHHA1; pfam02272
504472006441	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
504472006442	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
504472006443	DNA binding residues [nucleotide binding]
504472006444	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
504472006445	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
504472006446	Imelysin; Region: Peptidase_M75; cl09159
504472006447	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
504472006448	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
504472006449	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
504472006450	DNA protecting protein DprA; Region: dprA; TIGR00732
504472006451	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
504472006452	putative substrate binding site [chemical binding]; other site
504472006453	active site
504472006454	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
504472006455	ribosome recycling factor; Reviewed; Region: frr; PRK00083
504472006456	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
504472006457	hinge region; other site
504472006458	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
504472006459	putative nucleotide binding site [chemical binding]; other site
504472006460	uridine monophosphate binding site [chemical binding]; other site
504472006461	homohexameric interface [polypeptide binding]; other site
504472006462	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472006463	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
504472006464	carboxyltransferase (CT) interaction site; other site
504472006465	biotinylation site [posttranslational modification]; other site
504472006466	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
504472006467	EamA-like transporter family; Region: EamA; pfam00892
504472006468	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
504472006469	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
504472006470	FMN binding site [chemical binding]; other site
504472006471	active site
504472006472	catalytic residues [active]
504472006473	substrate binding site [chemical binding]; other site
504472006474	CAAX protease self-immunity; Region: Abi; pfam02517
504472006475	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
504472006476	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
504472006477	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
504472006478	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006479	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472006481	binding surface
504472006482	TPR motif; other site
504472006483	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006484	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472006486	binding surface
504472006487	TPR motif; other site
504472006488	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472006489	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006490	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
504472006491	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472006492	Phytase; Region: Phytase; cl17685
504472006493	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472006494	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
504472006495	putative active site [active]
504472006496	putative metal binding site [ion binding]; other site
504472006497	Mediator complex subunit 29; Region: Med29; pfam11568
504472006498	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
504472006499	biotin synthase; Region: bioB; TIGR00433
504472006500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472006501	FeS/SAM binding site; other site
504472006502	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
504472006503	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
504472006504	Acyltransferase family; Region: Acyl_transf_3; pfam01757
504472006505	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472006506	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472006507	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
504472006508	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
504472006509	tandem repeat interface [polypeptide binding]; other site
504472006510	oligomer interface [polypeptide binding]; other site
504472006511	active site residues [active]
504472006512	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
504472006513	tandem repeat interface [polypeptide binding]; other site
504472006514	oligomer interface [polypeptide binding]; other site
504472006515	active site residues [active]
504472006516	inorganic pyrophosphatase; Provisional; Region: PRK00642
504472006517	dimer interface [polypeptide binding]; other site
504472006518	substrate binding site [chemical binding]; other site
504472006519	metal binding sites [ion binding]; metal-binding site
504472006520	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
504472006521	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
504472006522	Ligand binding site; other site
504472006523	Putative Catalytic site; other site
504472006524	DXD motif; other site
504472006525	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
504472006526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472006527	S-adenosylmethionine binding site [chemical binding]; other site
504472006528	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472006529	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006530	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472006531	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472006532	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472006533	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472006534	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
504472006535	active site
504472006536	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
504472006537	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
504472006538	Na binding site [ion binding]; other site
504472006539	PIN domain; Region: PIN_3; pfam13470
504472006540	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
504472006541	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472006542	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
504472006543	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
504472006544	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
504472006545	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
504472006546	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
504472006547	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
504472006548	RNA/DNA hybrid binding site [nucleotide binding]; other site
504472006549	active site
504472006550	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472006551	peptidase T; Region: peptidase-T; TIGR01882
504472006552	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
504472006553	metal binding site [ion binding]; metal-binding site
504472006554	dimer interface [polypeptide binding]; other site
504472006555	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
504472006556	metal binding site [ion binding]; metal-binding site
504472006557	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
504472006558	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472006559	metal binding site [ion binding]; metal-binding site
504472006560	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
504472006561	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
504472006562	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
504472006563	glutamine synthetase; Region: PLN02284
504472006564	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
504472006565	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
504472006566	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
504472006567	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
504472006568	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472006569	catalytic residue [active]
504472006570	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
504472006571	Dehydroquinase class II; Region: DHquinase_II; pfam01220
504472006572	active site
504472006573	trimer interface [polypeptide binding]; other site
504472006574	dimer interface [polypeptide binding]; other site
504472006575	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
504472006576	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
504472006577	active site
504472006578	Int/Topo IB signature motif; other site
504472006579	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
504472006580	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
504472006581	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472006582	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472006583	catalytic residue [active]
504472006584	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
504472006585	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472006586	putative metal binding site [ion binding]; other site
504472006587	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
504472006588	catalytic core [active]
504472006589	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
504472006590	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
504472006591	putative dimer interface [polypeptide binding]; other site
504472006592	putative anticodon binding site; other site
504472006593	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
504472006594	homodimer interface [polypeptide binding]; other site
504472006595	motif 1; other site
504472006596	motif 2; other site
504472006597	active site
504472006598	motif 3; other site
504472006599	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
504472006600	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
504472006601	Ion transport protein; Region: Ion_trans; pfam00520
504472006602	Ion channel; Region: Ion_trans_2; pfam07885
504472006603	Double zinc ribbon; Region: DZR; pfam12773
504472006604	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
504472006605	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
504472006606	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472006607	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
504472006608	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
504472006609	classical (c) SDRs; Region: SDR_c; cd05233
504472006610	NAD(P) binding site [chemical binding]; other site
504472006611	active site
504472006612	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
504472006613	DEAD-like helicases superfamily; Region: DEXDc; smart00487
504472006614	ATP binding site [chemical binding]; other site
504472006615	Mg++ binding site [ion binding]; other site
504472006616	motif III; other site
504472006617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472006618	nucleotide binding region [chemical binding]; other site
504472006619	ATP-binding site [chemical binding]; other site
504472006620	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
504472006621	PQQ-like domain; Region: PQQ_2; pfam13360
504472006622	Trp docking motif [polypeptide binding]; other site
504472006623	putative active site [active]
504472006624	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472006625	Cytochrome c; Region: Cytochrom_C; pfam00034
504472006626	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472006627	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
504472006628	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
504472006629	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472006630	SusD family; Region: SusD; pfam07980
504472006631	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472006632	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006633	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472006634	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472006635	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
504472006636	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
504472006637	active site
504472006638	catalytic triad [active]
504472006639	oxyanion hole [active]
504472006640	Core-2/I-Branching enzyme; Region: Branch; pfam02485
504472006641	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472006642	active site
504472006643	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
504472006644	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
504472006645	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
504472006646	putative active site [active]
504472006647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472006648	active site
504472006649	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
504472006650	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
504472006651	active site
504472006652	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
504472006653	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
504472006654	Walker A/P-loop; other site
504472006655	ATP binding site [chemical binding]; other site
504472006656	Q-loop/lid; other site
504472006657	ABC transporter signature motif; other site
504472006658	Walker B; other site
504472006659	D-loop; other site
504472006660	H-loop/switch region; other site
504472006661	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
504472006662	putative carbohydrate binding site [chemical binding]; other site
504472006663	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
504472006664	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
504472006665	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472006666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472006667	active site
504472006668	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
504472006669	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
504472006670	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472006671	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
504472006672	NADP binding site [chemical binding]; other site
504472006673	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472006674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472006675	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
504472006676	GntP family permease; Region: GntP_permease; pfam02447
504472006677	fructuronate transporter; Provisional; Region: PRK10034; cl15264
504472006678	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
504472006679	Family description; Region: VCBS; pfam13517
504472006680	Family description; Region: VCBS; pfam13517
504472006681	Family description; Region: VCBS; pfam13517
504472006682	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472006683	Family description; Region: VCBS; pfam13517
504472006684	Family description; Region: VCBS; pfam13517
504472006685	Family description; Region: VCBS; pfam13517
504472006686	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472006687	SusD family; Region: SusD; pfam07980
504472006688	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472006689	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006690	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472006691	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472006692	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472006693	SusD family; Region: SusD; pfam07980
504472006694	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472006695	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472006696	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472006697	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
504472006698	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
504472006699	generic binding surface II; other site
504472006700	ssDNA binding site; other site
504472006701	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472006702	ATP binding site [chemical binding]; other site
504472006703	putative Mg++ binding site [ion binding]; other site
504472006704	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472006705	nucleotide binding region [chemical binding]; other site
504472006706	ATP-binding site [chemical binding]; other site
504472006707	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
504472006708	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
504472006709	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
504472006710	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
504472006711	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
504472006712	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
504472006713	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
504472006714	putative active site [active]
504472006715	Zn binding site [ion binding]; other site
504472006716	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
504472006717	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472006718	NAD(P) binding site [chemical binding]; other site
504472006719	active site
504472006720	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
504472006721	dimerization interface [polypeptide binding]; other site
504472006722	metal binding site [ion binding]; metal-binding site
504472006723	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472006724	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472006725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472006726	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472006727	dimerization interface [polypeptide binding]; other site
504472006728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472006729	dimer interface [polypeptide binding]; other site
504472006730	phosphorylation site [posttranslational modification]
504472006731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472006732	ATP binding site [chemical binding]; other site
504472006733	Mg2+ binding site [ion binding]; other site
504472006734	G-X-G motif; other site
504472006735	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472006736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472006737	active site
504472006738	phosphorylation site [posttranslational modification]
504472006739	intermolecular recognition site; other site
504472006740	dimerization interface [polypeptide binding]; other site
504472006741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472006742	DNA binding site [nucleotide binding]
504472006743	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
504472006744	methionine sulfoxide reductase B; Provisional; Region: PRK00222
504472006745	SelR domain; Region: SelR; pfam01641
504472006746	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472006747	Serine hydrolase; Region: Ser_hydrolase; cl17834
504472006748	LysE type translocator; Region: LysE; cl00565
504472006749	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
504472006750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472006751	non-specific DNA binding site [nucleotide binding]; other site
504472006752	salt bridge; other site
504472006753	sequence-specific DNA binding site [nucleotide binding]; other site
504472006754	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
504472006755	5' RNA guide strand anchoring site; other site
504472006756	active site
504472006757	SIR2-like domain; Region: SIR2_2; pfam13289
504472006758	short chain dehydrogenase; Provisional; Region: PRK06180
504472006759	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472006760	NADP binding site [chemical binding]; other site
504472006761	active site
504472006762	steroid binding site; other site
504472006763	Uncharacterized conserved protein [Function unknown]; Region: COG2353
504472006764	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472006765	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472006766	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472006767	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
504472006768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472006769	active site
504472006770	phosphorylation site [posttranslational modification]
504472006771	intermolecular recognition site; other site
504472006772	dimerization interface [polypeptide binding]; other site
504472006773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472006774	Walker A motif; other site
504472006775	ATP binding site [chemical binding]; other site
504472006776	Walker B motif; other site
504472006777	arginine finger; other site
504472006778	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
504472006779	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472006780	PAS domain; Region: PAS_9; pfam13426
504472006781	putative active site [active]
504472006782	heme pocket [chemical binding]; other site
504472006783	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472006784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472006785	dimer interface [polypeptide binding]; other site
504472006786	phosphorylation site [posttranslational modification]
504472006787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472006788	ATP binding site [chemical binding]; other site
504472006789	Mg2+ binding site [ion binding]; other site
504472006790	G-X-G motif; other site
504472006791	Response regulator receiver domain; Region: Response_reg; pfam00072
504472006792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472006793	active site
504472006794	phosphorylation site [posttranslational modification]
504472006795	intermolecular recognition site; other site
504472006796	dimerization interface [polypeptide binding]; other site
504472006797	Electron transfer DM13; Region: DM13; pfam10517
504472006798	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
504472006799	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
504472006800	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
504472006801	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472006802	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472006803	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472006804	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
504472006805	active site
504472006806	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472006807	active site
504472006808	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
504472006809	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
504472006810	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
504472006811	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472006812	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
504472006813	glucose-1-dehydrogenase; Provisional; Region: PRK08936
504472006814	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
504472006815	NAD binding site [chemical binding]; other site
504472006816	homodimer interface [polypeptide binding]; other site
504472006817	active site
504472006818	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
504472006819	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
504472006820	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
504472006821	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
504472006822	MIP family channel proteins; Region: MIP; TIGR00861
504472006823	amphipathic channel; other site
504472006824	Asn-Pro-Ala signature motifs; other site
504472006825	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
504472006826	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
504472006827	iron-sulfur cluster [ion binding]; other site
504472006828	[2Fe-2S] cluster binding site [ion binding]; other site
504472006829	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
504472006830	YceI-like domain; Region: YceI; pfam04264
504472006831	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
504472006832	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
504472006833	malonyl-CoA binding site [chemical binding]; other site
504472006834	dimer interface [polypeptide binding]; other site
504472006835	active site
504472006836	product binding site; other site
504472006837	UbiA prenyltransferase family; Region: UbiA; pfam01040
504472006838	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
504472006839	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472006840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472006841	S-adenosylmethionine binding site [chemical binding]; other site
504472006842	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
504472006843	putative active site [active]
504472006844	Zn binding site [ion binding]; other site
504472006845	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
504472006846	putative ligand binding site [chemical binding]; other site
504472006847	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
504472006848	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
504472006849	dimer interface [polypeptide binding]; other site
504472006850	active site
504472006851	catalytic residue [active]
504472006852	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
504472006853	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
504472006854	nucleotide binding pocket [chemical binding]; other site
504472006855	K-X-D-G motif; other site
504472006856	catalytic site [active]
504472006857	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
504472006858	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
504472006859	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
504472006860	Dimer interface [polypeptide binding]; other site
504472006861	BRCT sequence motif; other site
504472006862	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
504472006863	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
504472006864	substrate binding site [chemical binding]; other site
504472006865	hexamer interface [polypeptide binding]; other site
504472006866	metal binding site [ion binding]; metal-binding site
504472006867	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
504472006868	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
504472006869	active site
504472006870	catalytic site [active]
504472006871	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
504472006872	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472006873	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472006874	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472006875	ligand binding site [chemical binding]; other site
504472006876	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
504472006877	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
504472006878	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
504472006879	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472006880	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
504472006881	Ligand binding site; other site
504472006882	Putative Catalytic site; other site
504472006883	DXD motif; other site
504472006884	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472006885	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472006886	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
504472006887	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472006888	Outer membrane efflux protein; Region: OEP; pfam02321
504472006889	Outer membrane efflux protein; Region: OEP; pfam02321
504472006890	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472006891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472006892	active site
504472006893	phosphorylation site [posttranslational modification]
504472006894	intermolecular recognition site; other site
504472006895	dimerization interface [polypeptide binding]; other site
504472006896	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472006897	DNA binding site [nucleotide binding]
504472006898	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472006899	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472006900	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472006901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472006902	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472006903	DNA-binding interface [nucleotide binding]; DNA binding site
504472006904	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
504472006905	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472006906	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472006907	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472006908	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472006909	Protein export membrane protein; Region: SecD_SecF; cl14618
504472006910	Outer membrane efflux protein; Region: OEP; pfam02321
504472006911	Outer membrane efflux protein; Region: OEP; pfam02321
504472006912	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
504472006913	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
504472006914	putative active site; other site
504472006915	catalytic triad [active]
504472006916	putative dimer interface [polypeptide binding]; other site
504472006917	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
504472006918	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
504472006919	nucleotide binding site [chemical binding]; other site
504472006920	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
504472006921	dimer interface [polypeptide binding]; other site
504472006922	active site
504472006923	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
504472006924	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
504472006925	Moco binding site; other site
504472006926	metal coordination site [ion binding]; other site
504472006927	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472006928	putative active site [active]
504472006929	Chorismate mutase type II; Region: CM_2; cl00693
504472006930	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
504472006931	Prephenate dehydratase; Region: PDT; pfam00800
504472006932	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
504472006933	putative L-Phe binding site [chemical binding]; other site
504472006934	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
504472006935	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
504472006936	ATP binding site [chemical binding]; other site
504472006937	Mg2+ binding site [ion binding]; other site
504472006938	G-X-G motif; other site
504472006939	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
504472006940	ATP binding site [chemical binding]; other site
504472006941	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
504472006942	active site
504472006943	putative metal-binding site [ion binding]; other site
504472006944	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
504472006945	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
504472006946	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472006947	SLBB domain; Region: SLBB; pfam10531
504472006948	SLBB domain; Region: SLBB; pfam10531
504472006949	SLBB domain; Region: SLBB; pfam10531
504472006950	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
504472006951	SLBB domain; Region: SLBB; pfam10531
504472006952	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
504472006953	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
504472006954	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
504472006955	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
504472006956	Walker A/P-loop; other site
504472006957	ATP binding site [chemical binding]; other site
504472006958	Q-loop/lid; other site
504472006959	ABC transporter signature motif; other site
504472006960	Walker B; other site
504472006961	D-loop; other site
504472006962	H-loop/switch region; other site
504472006963	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
504472006964	putative carbohydrate binding site [chemical binding]; other site
504472006965	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
504472006966	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
504472006967	inhibitor-cofactor binding pocket; inhibition site
504472006968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472006969	catalytic residue [active]
504472006970	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
504472006971	WbqC-like protein family; Region: WbqC; pfam08889
504472006972	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
504472006973	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
504472006974	putative trimer interface [polypeptide binding]; other site
504472006975	putative CoA binding site [chemical binding]; other site
504472006976	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472006977	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472006978	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472006979	active site
504472006980	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472006981	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472006982	putative active site [active]
504472006983	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472006984	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
504472006985	Probable Catalytic site; other site
504472006986	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
504472006987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472006988	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472006989	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
504472006990	metal-binding site
504472006991	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472006992	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472006993	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472006994	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
504472006995	putative ADP-binding pocket [chemical binding]; other site
504472006996	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
504472006997	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
504472006998	putative active site [active]
504472006999	putative catalytic site [active]
504472007000	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
504472007001	active site
504472007002	cosubstrate binding site; other site
504472007003	substrate binding site [chemical binding]; other site
504472007004	catalytic site [active]
504472007005	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472007006	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472007007	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472007008	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
504472007009	putative metal binding site; other site
504472007010	putative acyl transferase; Provisional; Region: PRK10502
504472007011	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
504472007012	putative trimer interface [polypeptide binding]; other site
504472007013	putative active site [active]
504472007014	putative substrate binding site [chemical binding]; other site
504472007015	putative CoA binding site [chemical binding]; other site
504472007016	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472007017	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
504472007018	metal-binding site
504472007019	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
504472007020	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
504472007021	Mg++ binding site [ion binding]; other site
504472007022	putative catalytic motif [active]
504472007023	substrate binding site [chemical binding]; other site
504472007024	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
504472007025	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
504472007026	TPP-binding site [chemical binding]; other site
504472007027	dimer interface [polypeptide binding]; other site
504472007028	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
504472007029	PYR/PP interface [polypeptide binding]; other site
504472007030	dimer interface [polypeptide binding]; other site
504472007031	TPP binding site [chemical binding]; other site
504472007032	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
504472007033	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
504472007034	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472007035	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
504472007036	active site
504472007037	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472007038	active site
504472007039	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472007040	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472007041	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472007042	Response regulator receiver domain; Region: Response_reg; pfam00072
504472007043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007044	active site
504472007045	phosphorylation site [posttranslational modification]
504472007046	intermolecular recognition site; other site
504472007047	dimerization interface [polypeptide binding]; other site
504472007048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007049	active site
504472007050	phosphorylation site [posttranslational modification]
504472007051	intermolecular recognition site; other site
504472007052	dimerization interface [polypeptide binding]; other site
504472007053	LytTr DNA-binding domain; Region: LytTR; smart00850
504472007054	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472007055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007056	active site
504472007057	phosphorylation site [posttranslational modification]
504472007058	intermolecular recognition site; other site
504472007059	dimerization interface [polypeptide binding]; other site
504472007060	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
504472007061	30S subunit binding site; other site
504472007062	Domain of unknown function (DUF336); Region: DUF336; cl01249
504472007063	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
504472007064	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
504472007065	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
504472007066	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
504472007067	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472007068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472007069	S-adenosylmethionine binding site [chemical binding]; other site
504472007070	Predicted acyl esterases [General function prediction only]; Region: COG2936
504472007071	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
504472007072	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
504472007073	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472007074	DNA-binding site [nucleotide binding]; DNA binding site
504472007075	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472007076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472007077	homodimer interface [polypeptide binding]; other site
504472007078	catalytic residue [active]
504472007079	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
504472007080	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472007081	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472007082	catalytic residue [active]
504472007083	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
504472007084	DinB superfamily; Region: DinB_2; pfam12867
504472007085	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472007086	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472007087	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472007088	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472007089	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472007090	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472007091	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472007092	HAMP domain; Region: HAMP; pfam00672
504472007093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007094	dimer interface [polypeptide binding]; other site
504472007095	phosphorylation site [posttranslational modification]
504472007096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007097	ATP binding site [chemical binding]; other site
504472007098	G-X-G motif; other site
504472007099	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472007100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007101	active site
504472007102	phosphorylation site [posttranslational modification]
504472007103	intermolecular recognition site; other site
504472007104	dimerization interface [polypeptide binding]; other site
504472007105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472007106	DNA binding site [nucleotide binding]
504472007107	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
504472007108	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
504472007109	Cl- selectivity filter; other site
504472007110	Cl- binding residues [ion binding]; other site
504472007111	pore gating glutamate residue; other site
504472007112	dimer interface [polypeptide binding]; other site
504472007113	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472007114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472007115	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472007116	putative substrate translocation pore; other site
504472007117	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
504472007118	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
504472007119	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
504472007120	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
504472007121	Class I aldolases; Region: Aldolase_Class_I; cl17187
504472007122	catalytic residue [active]
504472007123	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472007124	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472007125	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007126	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472007127	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472007128	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472007129	Transcriptional regulators [Transcription]; Region: FadR; COG2186
504472007130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472007131	DNA-binding site [nucleotide binding]; DNA binding site
504472007132	FCD domain; Region: FCD; pfam07729
504472007133	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
504472007134	catalytic site [active]
504472007135	BNR repeat-like domain; Region: BNR_2; pfam13088
504472007136	Asp-box motif; other site
504472007137	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
504472007138	dimerization interface [polypeptide binding]; other site
504472007139	putative active cleft [active]
504472007140	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
504472007141	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
504472007142	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
504472007143	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
504472007144	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
504472007145	nudix motif; other site
504472007146	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
504472007147	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
504472007148	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472007149	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472007150	motif II; other site
504472007151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472007152	putative substrate translocation pore; other site
504472007153	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472007154	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
504472007155	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
504472007156	putative substrate binding site [chemical binding]; other site
504472007157	active site
504472007158	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472007159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472007160	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
504472007161	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
504472007162	putative NAD(P) binding site [chemical binding]; other site
504472007163	hypothetical protein; Provisional; Region: PRK02947
504472007164	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
504472007165	putative active site [active]
504472007166	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
504472007167	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
504472007168	nucleotide binding site [chemical binding]; other site
504472007169	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
504472007170	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472007171	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
504472007172	substrate binding site [chemical binding]; other site
504472007173	dimer interface [polypeptide binding]; other site
504472007174	ATP binding site [chemical binding]; other site
504472007175	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
504472007176	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472007177	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472007178	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
504472007179	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472007180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007181	dimer interface [polypeptide binding]; other site
504472007182	phosphorylation site [posttranslational modification]
504472007183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007184	ATP binding site [chemical binding]; other site
504472007185	G-X-G motif; other site
504472007186	Response regulator receiver domain; Region: Response_reg; pfam00072
504472007187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007188	active site
504472007189	phosphorylation site [posttranslational modification]
504472007190	intermolecular recognition site; other site
504472007191	dimerization interface [polypeptide binding]; other site
504472007192	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
504472007193	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
504472007194	glutaminase active site [active]
504472007195	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
504472007196	dimer interface [polypeptide binding]; other site
504472007197	active site
504472007198	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
504472007199	dimer interface [polypeptide binding]; other site
504472007200	active site
504472007201	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472007202	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472007203	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
504472007204	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472007205	Helix-turn-helix domain; Region: HTH_28; pfam13518
504472007206	Winged helix-turn helix; Region: HTH_29; pfam13551
504472007207	Homeodomain-like domain; Region: HTH_32; pfam13565
504472007208	Integrase core domain; Region: rve; pfam00665
504472007209	Integrase core domain; Region: rve_3; pfam13683
504472007210	Transposase; Region: HTH_Tnp_1; pfam01527
504472007211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
504472007212	Chain length determinant protein; Region: Wzz; cl15801
504472007213	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472007214	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
504472007215	Response regulator receiver domain; Region: Response_reg; pfam00072
504472007216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007217	active site
504472007218	phosphorylation site [posttranslational modification]
504472007219	intermolecular recognition site; other site
504472007220	dimerization interface [polypeptide binding]; other site
504472007221	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472007222	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472007223	von Willebrand factor type A domain; Region: VWA_2; pfam13519
504472007224	metal ion-dependent adhesion site (MIDAS); other site
504472007225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472007226	TPR motif; other site
504472007227	binding surface
504472007228	Eukaryotic protein of unknown function (DUF1764); Region: DUF1764; pfam08576
504472007229	acetyl-CoA C-acetyltransferase; Region: PLN02644
504472007230	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
504472007231	dimer interface [polypeptide binding]; other site
504472007232	active site
504472007233	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
504472007234	ATP binding site [chemical binding]; other site
504472007235	active site
504472007236	substrate binding site [chemical binding]; other site
504472007237	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
504472007238	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
504472007239	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
504472007240	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
504472007241	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
504472007242	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
504472007243	protein binding site [polypeptide binding]; other site
504472007244	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574
504472007245	malate:quinone oxidoreductase; Validated; Region: PRK05257
504472007246	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
504472007247	Right handed beta helix region; Region: Beta_helix; pfam13229
504472007248	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
504472007249	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
504472007250	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
504472007251	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
504472007252	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472007253	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
504472007254	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
504472007255	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472007256	active site residue [active]
504472007257	Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589
504472007258	putative active site [active]
504472007259	catalytic site [active]
504472007260	putative metal binding site [ion binding]; other site
504472007261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472007262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472007263	DNA binding site [nucleotide binding]
504472007264	domain linker motif; other site
504472007265	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472007266	ligand binding site [chemical binding]; other site
504472007267	dimerization interface [polypeptide binding]; other site
504472007268	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
504472007269	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
504472007270	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
504472007271	Protein of unknown function (DUF819); Region: DUF819; cl02317
504472007272	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472007273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472007274	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
504472007275	putative substrate translocation pore; other site
504472007276	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472007277	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
504472007278	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472007279	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472007280	Outer membrane efflux protein; Region: OEP; pfam02321
504472007281	Outer membrane efflux protein; Region: OEP; pfam02321
504472007282	MarR family; Region: MarR_2; cl17246
504472007283	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
504472007284	fumarate hydratase; Reviewed; Region: fumC; PRK00485
504472007285	Class II fumarases; Region: Fumarase_classII; cd01362
504472007286	active site
504472007287	tetramer interface [polypeptide binding]; other site
504472007288	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472007289	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472007290	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
504472007291	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
504472007292	putative active site [active]
504472007293	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
504472007294	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
504472007295	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
504472007296	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
504472007297	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
504472007298	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472007299	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472007300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472007301	Walker A/P-loop; other site
504472007302	ATP binding site [chemical binding]; other site
504472007303	Q-loop/lid; other site
504472007304	ABC transporter signature motif; other site
504472007305	Walker B; other site
504472007306	D-loop; other site
504472007307	H-loop/switch region; other site
504472007308	TIGR01666 family membrane protein; Region: YCCS
504472007309	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
504472007310	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
504472007311	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472007312	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472007313	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472007314	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
504472007315	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
504472007316	active site
504472007317	catalytic site [active]
504472007318	substrate binding site [chemical binding]; other site
504472007319	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472007320	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472007321	TPR motif; other site
504472007322	binding surface
504472007323	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472007324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472007325	binding surface
504472007326	TPR motif; other site
504472007327	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472007328	CHAT domain; Region: CHAT; pfam12770
504472007329	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
504472007330	active site
504472007331	catalytic residues [active]
504472007332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
504472007333	TPR motif; other site
504472007334	binding surface
504472007335	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472007336	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
504472007337	Peptidase family M50; Region: Peptidase_M50; pfam02163
504472007338	active site
504472007339	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
504472007340	putative substrate binding region [chemical binding]; other site
504472007341	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
504472007342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472007343	motif II; other site
504472007344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
504472007345	AAA domain; Region: AAA_21; pfam13304
504472007346	Walker A motif; other site
504472007347	ATP binding site [chemical binding]; other site
504472007348	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
504472007349	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
504472007350	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
504472007351	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
504472007352	Beta-Casp domain; Region: Beta-Casp; smart01027
504472007353	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
504472007354	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
504472007355	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472007356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007357	active site
504472007358	phosphorylation site [posttranslational modification]
504472007359	intermolecular recognition site; other site
504472007360	dimerization interface [polypeptide binding]; other site
504472007361	CHASE3 domain; Region: CHASE3; pfam05227
504472007362	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472007363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007364	dimer interface [polypeptide binding]; other site
504472007365	phosphorylation site [posttranslational modification]
504472007366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007367	ATP binding site [chemical binding]; other site
504472007368	Mg2+ binding site [ion binding]; other site
504472007369	G-X-G motif; other site
504472007370	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
504472007371	active site
504472007372	HslU subunit interaction site [polypeptide binding]; other site
504472007373	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
504472007374	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
504472007375	putative DNA binding site [nucleotide binding]; other site
504472007376	putative Zn2+ binding site [ion binding]; other site
504472007377	AsnC family; Region: AsnC_trans_reg; pfam01037
504472007378	GTP-binding protein LepA; Provisional; Region: PRK05433
504472007379	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
504472007380	G1 box; other site
504472007381	putative GEF interaction site [polypeptide binding]; other site
504472007382	GTP/Mg2+ binding site [chemical binding]; other site
504472007383	Switch I region; other site
504472007384	G2 box; other site
504472007385	G3 box; other site
504472007386	Switch II region; other site
504472007387	G4 box; other site
504472007388	G5 box; other site
504472007389	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
504472007390	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
504472007391	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
504472007392	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472007393	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472007394	catalytic residues [active]
504472007395	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
504472007396	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472007397	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
504472007398	ligand binding site [chemical binding]; other site
504472007399	flexible hinge region; other site
504472007400	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472007401	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007402	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472007403	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472007404	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472007405	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472007406	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
504472007407	proposed catalytic triad [active]
504472007408	active site nucleophile [active]
504472007409	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472007410	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
504472007411	Moco binding site; other site
504472007412	metal coordination site [ion binding]; other site
504472007413	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
504472007414	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472007415	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
504472007416	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472007417	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472007418	ligand binding site [chemical binding]; other site
504472007419	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
504472007420	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
504472007421	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
504472007422	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
504472007423	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
504472007424	Domain of unknown function DUF20; Region: UPF0118; pfam01594
504472007425	PspC domain; Region: PspC; pfam04024
504472007426	PspC domain; Region: PspC; pfam04024
504472007427	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
504472007428	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472007429	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
504472007430	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472007431	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472007432	ligand binding site [chemical binding]; other site
504472007433	flexible hinge region; other site
504472007434	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472007435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472007436	NAD(P) binding site [chemical binding]; other site
504472007437	active site
504472007438	HD domain; Region: HD_3; pfam13023
504472007439	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
504472007440	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472007441	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472007442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472007443	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
504472007444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472007445	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
504472007446	hydroxyglutarate oxidase; Provisional; Region: PRK11728
504472007447	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
504472007448	active site
504472007449	metal binding site [ion binding]; metal-binding site
504472007450	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472007451	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
504472007452	catalytic site [active]
504472007453	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472007454	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472007455	active site
504472007456	catalytic tetrad [active]
504472007457	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
504472007458	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472007459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472007460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
504472007461	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472007462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472007463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007464	dimer interface [polypeptide binding]; other site
504472007465	phosphorylation site [posttranslational modification]
504472007466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007467	ATP binding site [chemical binding]; other site
504472007468	Mg2+ binding site [ion binding]; other site
504472007469	G-X-G motif; other site
504472007470	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472007471	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472007472	DNA binding residues [nucleotide binding]
504472007473	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472007474	FecR protein; Region: FecR; pfam04773
504472007475	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472007476	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007477	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472007478	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472007479	SusD family; Region: SusD; pfam07980
504472007480	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
504472007481	active site
504472007482	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
504472007483	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
504472007484	NADP binding site [chemical binding]; other site
504472007485	substrate binding site [chemical binding]; other site
504472007486	active site
504472007487	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472007488	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472007489	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472007490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007491	active site
504472007492	phosphorylation site [posttranslational modification]
504472007493	intermolecular recognition site; other site
504472007494	dimerization interface [polypeptide binding]; other site
504472007495	LytTr DNA-binding domain; Region: LytTR; smart00850
504472007496	Histidine kinase; Region: His_kinase; pfam06580
504472007497	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472007498	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472007499	YCII-related domain; Region: YCII; cl00999
504472007500	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
504472007501	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472007502	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
504472007503	Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483
504472007504	active site
504472007505	catalytic triad [active]
504472007506	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
504472007507	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
504472007508	transposase/IS protein; Provisional; Region: PRK09183
504472007509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472007510	Walker A motif; other site
504472007511	ATP binding site [chemical binding]; other site
504472007512	Walker B motif; other site
504472007513	arginine finger; other site
504472007514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472007515	Integrase core domain; Region: rve; pfam00665
504472007516	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
504472007517	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472007518	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472007519	catalytic residues [active]
504472007520	Histidine kinase; Region: His_kinase; pfam06580
504472007521	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472007522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007523	active site
504472007524	phosphorylation site [posttranslational modification]
504472007525	intermolecular recognition site; other site
504472007526	dimerization interface [polypeptide binding]; other site
504472007527	LytTr DNA-binding domain; Region: LytTR; smart00850
504472007528	PAS fold; Region: PAS_3; pfam08447
504472007529	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472007530	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472007531	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472007532	putative active site [active]
504472007533	heme pocket [chemical binding]; other site
504472007534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472007535	putative active site [active]
504472007536	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472007537	heme pocket [chemical binding]; other site
504472007538	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007539	dimer interface [polypeptide binding]; other site
504472007540	phosphorylation site [posttranslational modification]
504472007541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007542	ATP binding site [chemical binding]; other site
504472007543	Mg2+ binding site [ion binding]; other site
504472007544	G-X-G motif; other site
504472007545	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472007546	PAS fold; Region: PAS_4; pfam08448
504472007547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007548	dimer interface [polypeptide binding]; other site
504472007549	phosphorylation site [posttranslational modification]
504472007550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007551	ATP binding site [chemical binding]; other site
504472007552	Mg2+ binding site [ion binding]; other site
504472007553	G-X-G motif; other site
504472007554	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472007555	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
504472007556	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
504472007557	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472007558	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
504472007559	active site
504472007560	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
504472007561	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
504472007562	Cation efflux family; Region: Cation_efflux; pfam01545
504472007563	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
504472007564	Thiamine pyrophosphokinase; Region: TPK; cd07995
504472007565	active site
504472007566	dimerization interface [polypeptide binding]; other site
504472007567	thiamine binding site [chemical binding]; other site
504472007568	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
504472007569	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
504472007570	Ligand binding site; other site
504472007571	oligomer interface; other site
504472007572	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472007573	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
504472007574	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
504472007575	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
504472007576	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
504472007577	active site
504472007578	NAD binding site [chemical binding]; other site
504472007579	metal binding site [ion binding]; metal-binding site
504472007580	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
504472007581	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
504472007582	inhibitor-cofactor binding pocket; inhibition site
504472007583	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472007584	catalytic residue [active]
504472007585	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
504472007586	nucleoside/Zn binding site; other site
504472007587	dimer interface [polypeptide binding]; other site
504472007588	catalytic motif [active]
504472007589	Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909
504472007590	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
504472007591	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
504472007592	GTP binding site; other site
504472007593	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
504472007594	trimer interface [polypeptide binding]; other site
504472007595	dimer interface [polypeptide binding]; other site
504472007596	putative active site [active]
504472007597	Ferritin-like domain; Region: Ferritin_2; pfam13668
504472007598	Ferritin-like domain; Region: Ferritin_2; pfam13668
504472007599	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
504472007600	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
504472007601	dimer interface [polypeptide binding]; other site
504472007602	putative functional site; other site
504472007603	putative MPT binding site; other site
504472007604	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
504472007605	Zn2+ binding site [ion binding]; other site
504472007606	Mg2+ binding site [ion binding]; other site
504472007607	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472007608	active site
504472007609	metal binding site [ion binding]; metal-binding site
504472007610	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472007611	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
504472007612	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472007613	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472007614	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472007615	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472007616	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
504472007617	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472007618	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472007619	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
504472007620	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472007621	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472007622	putative active site [active]
504472007623	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
504472007624	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472007625	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472007626	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
504472007627	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
504472007628	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
504472007629	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
504472007630	Chromate transporter; Region: Chromate_transp; pfam02417
504472007631	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472007632	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472007633	putative active site [active]
504472007634	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472007635	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007636	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472007637	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472007638	hypothetical protein; Provisional; Region: PRK08609
504472007639	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
504472007640	metal binding triad [ion binding]; metal-binding site
504472007641	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
504472007642	active site
504472007643	2TM domain; Region: 2TM; pfam13239
504472007644	thymidylate synthase; Reviewed; Region: thyA; PRK01827
504472007645	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
504472007646	dimerization interface [polypeptide binding]; other site
504472007647	active site
504472007648	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
504472007649	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
504472007650	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
504472007651	active site
504472007652	FMN binding site [chemical binding]; other site
504472007653	substrate binding site [chemical binding]; other site
504472007654	putative catalytic residue [active]
504472007655	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
504472007656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472007657	NAD(P) binding site [chemical binding]; other site
504472007658	active site
504472007659	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472007660	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472007661	putative sialic acid transporter; Region: 2A0112; TIGR00891
504472007662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472007663	putative substrate translocation pore; other site
504472007664	CAAX protease self-immunity; Region: Abi; pfam02517
504472007665	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
504472007666	Transglycosylase; Region: Transgly; cl17702
504472007667	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
504472007668	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472007669	FeS/SAM binding site; other site
504472007670	HemN C-terminal domain; Region: HemN_C; pfam06969
504472007671	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472007672	Coenzyme A binding pocket [chemical binding]; other site
504472007673	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
504472007674	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
504472007675	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472007676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472007677	motif II; other site
504472007678	YCII-related domain; Region: YCII; cl00999
504472007679	HEPN domain; Region: HEPN; cl00824
504472007680	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
504472007681	active site
504472007682	NTP binding site [chemical binding]; other site
504472007683	metal binding triad [ion binding]; metal-binding site
504472007684	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
504472007685	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472007686	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472007687	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
504472007688	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
504472007689	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472007690	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
504472007691	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472007692	active site
504472007693	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
504472007694	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
504472007695	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
504472007696	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
504472007697	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
504472007698	active site
504472007699	substrate binding site [chemical binding]; other site
504472007700	metal binding site [ion binding]; metal-binding site
504472007701	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
504472007702	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
504472007703	YtxH-like protein; Region: YtxH; pfam12732
504472007704	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472007705	GMP synthase; Reviewed; Region: guaA; PRK00074
504472007706	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
504472007707	AMP/PPi binding site [chemical binding]; other site
504472007708	candidate oxyanion hole; other site
504472007709	catalytic triad [active]
504472007710	potential glutamine specificity residues [chemical binding]; other site
504472007711	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
504472007712	ATP Binding subdomain [chemical binding]; other site
504472007713	Ligand Binding sites [chemical binding]; other site
504472007714	Dimerization subdomain; other site
504472007715	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472007716	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472007717	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472007718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472007719	Domain of unknown function (DUF4047); Region: DUF4047; pfam13256
504472007720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007721	dimer interface [polypeptide binding]; other site
504472007722	phosphorylation site [posttranslational modification]
504472007723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007724	ATP binding site [chemical binding]; other site
504472007725	Mg2+ binding site [ion binding]; other site
504472007726	G-X-G motif; other site
504472007727	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
504472007728	FtsX-like permease family; Region: FtsX; pfam02687
504472007729	SdiA-regulated; Region: SdiA-regulated; cd09971
504472007730	SdiA-regulated; Region: SdiA-regulated; pfam06977
504472007731	putative active site [active]
504472007732	Histidine kinase; Region: His_kinase; pfam06580
504472007733	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472007734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007735	active site
504472007736	phosphorylation site [posttranslational modification]
504472007737	intermolecular recognition site; other site
504472007738	dimerization interface [polypeptide binding]; other site
504472007739	LytTr DNA-binding domain; Region: LytTR; smart00850
504472007740	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
504472007741	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
504472007742	RNA binding surface [nucleotide binding]; other site
504472007743	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
504472007744	active site
504472007745	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
504472007746	Ligand binding site; other site
504472007747	Putative Catalytic site; other site
504472007748	DXD motif; other site
504472007749	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007750	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472007751	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472007752	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
504472007753	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
504472007754	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007755	beta-phosphoglucomutase; Region: bPGM; TIGR01990
504472007756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472007757	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
504472007758	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
504472007759	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472007760	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472007761	ligand binding site [chemical binding]; other site
504472007762	flexible hinge region; other site
504472007763	PAS fold; Region: PAS_4; pfam08448
504472007764	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007765	dimer interface [polypeptide binding]; other site
504472007766	phosphorylation site [posttranslational modification]
504472007767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007768	ATP binding site [chemical binding]; other site
504472007769	G-X-G motif; other site
504472007770	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
504472007771	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
504472007772	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
504472007773	Ca binding site [ion binding]; other site
504472007774	active site
504472007775	homodimer interface [polypeptide binding]; other site
504472007776	catalytic site [active]
504472007777	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
504472007778	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
504472007779	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
504472007780	active site
504472007781	catalytic site [active]
504472007782	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
504472007783	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
504472007784	peptidase domain interface [polypeptide binding]; other site
504472007785	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
504472007786	active site
504472007787	catalytic triad [active]
504472007788	calcium binding site [ion binding]; other site
504472007789	Predicted membrane protein [Function unknown]; Region: COG2510
504472007790	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
504472007791	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
504472007792	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
504472007793	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
504472007794	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
504472007795	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
504472007796	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
504472007797	acetyl-CoA synthetase; Provisional; Region: PRK00174
504472007798	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
504472007799	active site
504472007800	CoA binding site [chemical binding]; other site
504472007801	acyl-activating enzyme (AAE) consensus motif; other site
504472007802	AMP binding site [chemical binding]; other site
504472007803	acetate binding site [chemical binding]; other site
504472007804	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472007805	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472007806	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
504472007807	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472007808	putative active site [active]
504472007809	Predicted membrane protein [Function unknown]; Region: COG3503
504472007810	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472007811	mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547
504472007812	Kelch motif; Region: Kelch_6; pfam13964
504472007813	Kelch motif; Region: Kelch_1; pfam01344
504472007814	Kelch motif; Region: Kelch_1; pfam01344
504472007815	Kelch motif; Region: Kelch_1; pfam01344
504472007816	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
504472007817	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
504472007818	tetramer interface [polypeptide binding]; other site
504472007819	heme binding pocket [chemical binding]; other site
504472007820	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
504472007821	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472007822	putative DNA binding site [nucleotide binding]; other site
504472007823	putative Zn2+ binding site [ion binding]; other site
504472007824	AsnC family; Region: AsnC_trans_reg; pfam01037
504472007825	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
504472007826	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
504472007827	hexamer interface [polypeptide binding]; other site
504472007828	ligand binding site [chemical binding]; other site
504472007829	putative active site [active]
504472007830	NAD(P) binding site [chemical binding]; other site
504472007831	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
504472007832	heme-binding site [chemical binding]; other site
504472007833	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
504472007834	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472007835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007836	active site
504472007837	phosphorylation site [posttranslational modification]
504472007838	intermolecular recognition site; other site
504472007839	dimerization interface [polypeptide binding]; other site
504472007840	LytTr DNA-binding domain; Region: LytTR; smart00850
504472007841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
504472007842	Histidine kinase; Region: His_kinase; pfam06580
504472007843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007844	Mg2+ binding site [ion binding]; other site
504472007845	G-X-G motif; other site
504472007846	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
504472007847	catalytic core [active]
504472007848	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
504472007849	CoenzymeA binding site [chemical binding]; other site
504472007850	subunit interaction site [polypeptide binding]; other site
504472007851	PHB binding site; other site
504472007852	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
504472007853	Malic enzyme, N-terminal domain; Region: malic; pfam00390
504472007854	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
504472007855	putative NAD(P) binding site [chemical binding]; other site
504472007856	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
504472007857	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
504472007858	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
504472007859	active site
504472007860	HIGH motif; other site
504472007861	dimer interface [polypeptide binding]; other site
504472007862	KMSKS motif; other site
504472007863	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472007864	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472007865	DNA binding residues [nucleotide binding]
504472007866	dimerization interface [polypeptide binding]; other site
504472007867	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007868	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472007869	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472007870	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472007871	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472007872	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472007873	AP (apurinic/apyrimidinic) site pocket; other site
504472007874	DNA interaction; other site
504472007875	Metal-binding active site; metal-binding site
504472007876	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
504472007877	active site
504472007878	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472007879	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472007880	active site
504472007881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472007882	S-adenosylmethionine binding site [chemical binding]; other site
504472007883	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
504472007884	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
504472007885	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
504472007886	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
504472007887	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
504472007888	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472007889	active site
504472007890	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
504472007891	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
504472007892	5S rRNA interface [nucleotide binding]; other site
504472007893	CTC domain interface [polypeptide binding]; other site
504472007894	L16 interface [polypeptide binding]; other site
504472007895	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
504472007896	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
504472007897	metal-binding site [ion binding]
504472007898	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472007899	Soluble P-type ATPase [General function prediction only]; Region: COG4087
504472007900	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
504472007901	metal-binding site [ion binding]
504472007902	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472007903	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
504472007904	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
504472007905	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472007906	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472007907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007908	active site
504472007909	phosphorylation site [posttranslational modification]
504472007910	intermolecular recognition site; other site
504472007911	dimerization interface [polypeptide binding]; other site
504472007912	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472007913	DNA binding site [nucleotide binding]
504472007914	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472007915	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472007916	dimerization interface [polypeptide binding]; other site
504472007917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007918	dimer interface [polypeptide binding]; other site
504472007919	phosphorylation site [posttranslational modification]
504472007920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007921	ATP binding site [chemical binding]; other site
504472007922	Mg2+ binding site [ion binding]; other site
504472007923	G-X-G motif; other site
504472007924	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
504472007925	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
504472007926	hinge; other site
504472007927	active site
504472007928	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
504472007929	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472007930	active site
504472007931	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472007932	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472007933	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472007934	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472007935	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472007936	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
504472007937	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
504472007938	catalytic motif [active]
504472007939	Zn binding site [ion binding]; other site
504472007940	RibD C-terminal domain; Region: RibD_C; pfam01872
504472007941	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
504472007942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472007943	S-adenosylmethionine binding site [chemical binding]; other site
504472007944	MoxR-like ATPases [General function prediction only]; Region: COG0714
504472007945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472007946	Walker A motif; other site
504472007947	ATP binding site [chemical binding]; other site
504472007948	Walker B motif; other site
504472007949	arginine finger; other site
504472007950	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
504472007951	SelR domain; Region: SelR; pfam01641
504472007952	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
504472007953	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472007954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472007955	active site
504472007956	phosphorylation site [posttranslational modification]
504472007957	intermolecular recognition site; other site
504472007958	dimerization interface [polypeptide binding]; other site
504472007959	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472007960	DNA binding site [nucleotide binding]
504472007961	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472007962	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472007963	dimerization interface [polypeptide binding]; other site
504472007964	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472007965	dimer interface [polypeptide binding]; other site
504472007966	phosphorylation site [posttranslational modification]
504472007967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472007968	ATP binding site [chemical binding]; other site
504472007969	Mg2+ binding site [ion binding]; other site
504472007970	G-X-G motif; other site
504472007971	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472007972	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472007973	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472007974	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
504472007975	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472007976	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
504472007977	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472007978	active site
504472007979	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
504472007980	Putative Catalytic site; other site
504472007981	DXD motif; other site
504472007982	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472007983	active site
504472007984	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
504472007985	EamA-like transporter family; Region: EamA; pfam00892
504472007986	Predicted permeases [General function prediction only]; Region: COG0795
504472007987	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
504472007988	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
504472007989	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
504472007990	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
504472007991	FeoA domain; Region: FeoA; pfam04023
504472007992	manganese transport protein MntH; Reviewed; Region: PRK00701
504472007993	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
504472007994	BNR repeat-like domain; Region: BNR_2; pfam13088
504472007995	transposase/IS protein; Provisional; Region: PRK09183
504472007996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472007997	Walker A motif; other site
504472007998	ATP binding site [chemical binding]; other site
504472007999	Walker B motif; other site
504472008000	arginine finger; other site
504472008001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472008002	Integrase core domain; Region: rve; pfam00665
504472008003	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472008004	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472008005	DNA binding residues [nucleotide binding]
504472008006	PKD domain; Region: PKD; pfam00801
504472008007	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472008008	Interdomain contacts; other site
504472008009	Cytokine receptor motif; other site
504472008010	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472008011	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472008012	binding surface
504472008013	TPR motif; other site
504472008014	TPR repeat; Region: TPR_11; pfam13414
504472008015	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
504472008016	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
504472008017	active site
504472008018	ATP binding site [chemical binding]; other site
504472008019	substrate binding site [chemical binding]; other site
504472008020	activation loop (A-loop); other site
504472008021	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
504472008022	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
504472008023	active site
504472008024	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
504472008025	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
504472008026	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
504472008027	phosphopeptide binding site; other site
504472008028	K+ potassium transporter; Region: K_trans; pfam02705
504472008029	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472008030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472008031	NAD(P) binding site [chemical binding]; other site
504472008032	active site
504472008033	Protein of unknown function DUF72; Region: DUF72; pfam01904
504472008034	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
504472008035	active site
504472008036	catalytic residues [active]
504472008037	Abhydrolase family; Region: Abhydrolase_7; pfam12715
504472008038	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472008039	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472008040	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472008041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008042	dimer interface [polypeptide binding]; other site
504472008043	phosphorylation site [posttranslational modification]
504472008044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008045	ATP binding site [chemical binding]; other site
504472008046	Mg2+ binding site [ion binding]; other site
504472008047	G-X-G motif; other site
504472008048	Response regulator receiver domain; Region: Response_reg; pfam00072
504472008049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008050	active site
504472008051	phosphorylation site [posttranslational modification]
504472008052	intermolecular recognition site; other site
504472008053	dimerization interface [polypeptide binding]; other site
504472008054	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472008055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472008056	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472008057	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472008058	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008059	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472008060	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
504472008061	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472008062	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472008063	Trp docking motif [polypeptide binding]; other site
504472008064	active site
504472008065	PQQ-like domain; Region: PQQ_2; pfam13360
504472008066	PQQ-like domain; Region: PQQ_2; pfam13360
504472008067	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472008068	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472008069	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
504472008070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472008071	salt bridge; other site
504472008072	non-specific DNA binding site [nucleotide binding]; other site
504472008073	sequence-specific DNA binding site [nucleotide binding]; other site
504472008074	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
504472008075	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
504472008076	active site
504472008077	substrate binding site [chemical binding]; other site
504472008078	metal binding site [ion binding]; metal-binding site
504472008079	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472008080	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472008081	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472008082	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472008083	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472008084	SusD family; Region: SusD; pfam07980
504472008085	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
504472008086	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
504472008087	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
504472008088	hexamer interface [polypeptide binding]; other site
504472008089	ligand binding site [chemical binding]; other site
504472008090	putative active site [active]
504472008091	NAD(P) binding site [chemical binding]; other site
504472008092	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
504472008093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008094	ATP binding site [chemical binding]; other site
504472008095	Mg2+ binding site [ion binding]; other site
504472008096	G-X-G motif; other site
504472008097	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
504472008098	anchoring element; other site
504472008099	dimer interface [polypeptide binding]; other site
504472008100	ATP binding site [chemical binding]; other site
504472008101	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
504472008102	active site
504472008103	putative metal-binding site [ion binding]; other site
504472008104	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
504472008105	polyphosphate kinase; Provisional; Region: PRK05443
504472008106	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
504472008107	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
504472008108	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
504472008109	putative domain interface [polypeptide binding]; other site
504472008110	putative active site [active]
504472008111	catalytic site [active]
504472008112	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
504472008113	putative domain interface [polypeptide binding]; other site
504472008114	putative active site [active]
504472008115	catalytic site [active]
504472008116	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
504472008117	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
504472008118	Nucleoside recognition; Region: Gate; pfam07670
504472008119	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
504472008120	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
504472008121	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
504472008122	dimer interface [polypeptide binding]; other site
504472008123	acyl-activating enzyme (AAE) consensus motif; other site
504472008124	putative active site [active]
504472008125	AMP binding site [chemical binding]; other site
504472008126	putative CoA binding site [chemical binding]; other site
504472008127	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
504472008128	active site
504472008129	metal binding site [ion binding]; metal-binding site
504472008130	homotetramer interface [polypeptide binding]; other site
504472008131	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
504472008132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472008133	Walker A motif; other site
504472008134	ATP binding site [chemical binding]; other site
504472008135	Walker B motif; other site
504472008136	arginine finger; other site
504472008137	Peptidase family M41; Region: Peptidase_M41; pfam01434
504472008138	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
504472008139	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
504472008140	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
504472008141	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
504472008142	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
504472008143	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472008144	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472008145	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
504472008146	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
504472008147	substrate binding pocket [chemical binding]; other site
504472008148	chain length determination region; other site
504472008149	substrate-Mg2+ binding site; other site
504472008150	catalytic residues [active]
504472008151	aspartate-rich region 1; other site
504472008152	active site lid residues [active]
504472008153	aspartate-rich region 2; other site
504472008154	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
504472008155	active site
504472008156	nucleophile elbow; other site
504472008157	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
504472008158	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
504472008159	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
504472008160	putative active site [active]
504472008161	catalytic site [active]
504472008162	putative metal binding site [ion binding]; other site
504472008163	oligomer interface [polypeptide binding]; other site
504472008164	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472008165	selenophosphate synthetase; Provisional; Region: PRK00943
504472008166	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
504472008167	dimerization interface [polypeptide binding]; other site
504472008168	putative ATP binding site [chemical binding]; other site
504472008169	acyl-CoA esterase; Provisional; Region: PRK10673
504472008170	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472008171	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
504472008172	putative SAM binding site [chemical binding]; other site
504472008173	homodimer interface [polypeptide binding]; other site
504472008174	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
504472008175	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
504472008176	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
504472008177	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
504472008178	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
504472008179	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
504472008180	dimer interface [polypeptide binding]; other site
504472008181	active site
504472008182	CoA binding pocket [chemical binding]; other site
504472008183	CoA binding domain; Region: CoA_binding_2; pfam13380
504472008184	NUMOD4 motif; Region: NUMOD4; pfam07463
504472008185	HNH endonuclease; Region: HNH_3; pfam13392
504472008186	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472008187	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472008188	dimerization interface [polypeptide binding]; other site
504472008189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008190	dimer interface [polypeptide binding]; other site
504472008191	phosphorylation site [posttranslational modification]
504472008192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008193	ATP binding site [chemical binding]; other site
504472008194	Mg2+ binding site [ion binding]; other site
504472008195	G-X-G motif; other site
504472008196	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
504472008197	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
504472008198	active site
504472008199	catalytic residues [active]
504472008200	metal binding site [ion binding]; metal-binding site
504472008201	TPR repeat; Region: TPR_11; pfam13414
504472008202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472008203	binding surface
504472008204	TPR motif; other site
504472008205	TPR repeat; Region: TPR_11; pfam13414
504472008206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472008207	binding surface
504472008208	TPR motif; other site
504472008209	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
504472008210	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
504472008211	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
504472008212	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
504472008213	active site
504472008214	intersubunit interactions; other site
504472008215	catalytic residue [active]
504472008216	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
504472008217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472008218	Walker A/P-loop; other site
504472008219	ATP binding site [chemical binding]; other site
504472008220	Q-loop/lid; other site
504472008221	ABC transporter signature motif; other site
504472008222	Walker B; other site
504472008223	D-loop; other site
504472008224	H-loop/switch region; other site
504472008225	Family description; Region: VCBS; pfam13517
504472008226	Family description; Region: VCBS; pfam13517
504472008227	Family description; Region: VCBS; pfam13517
504472008228	Family description; Region: VCBS; pfam13517
504472008229	Family description; Region: VCBS; pfam13517
504472008230	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472008231	Family description; Region: VCBS; pfam13517
504472008232	Family description; Region: VCBS; pfam13517
504472008233	Family description; Region: VCBS; pfam13517
504472008234	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472008235	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472008236	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472008237	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472008238	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472008239	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008240	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
504472008241	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
504472008242	active site
504472008243	Family description; Region: VCBS; pfam13517
504472008244	Family description; Region: VCBS; pfam13517
504472008245	Family description; Region: VCBS; pfam13517
504472008246	Family description; Region: VCBS; pfam13517
504472008247	Family description; Region: VCBS; pfam13517
504472008248	Family description; Region: VCBS; pfam13517
504472008249	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472008250	Family description; Region: VCBS; pfam13517
504472008251	Family description; Region: VCBS; pfam13517
504472008252	Family description; Region: VCBS; pfam13517
504472008253	Family description; Region: VCBS; pfam13517
504472008254	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472008255	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472008256	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472008257	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472008258	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472008259	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472008260	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
504472008261	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472008262	Family description; Region: VCBS; pfam13517
504472008263	Family description; Region: VCBS; pfam13517
504472008264	Family description; Region: VCBS; pfam13517
504472008265	Family description; Region: VCBS; pfam13517
504472008266	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472008267	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472008268	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472008269	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472008270	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008271	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472008272	MarR family; Region: MarR_2; pfam12802
504472008273	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
504472008274	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
504472008275	nucleotide binding site [chemical binding]; other site
504472008276	Response regulator receiver domain; Region: Response_reg; pfam00072
504472008277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008278	active site
504472008279	phosphorylation site [posttranslational modification]
504472008280	intermolecular recognition site; other site
504472008281	dimerization interface [polypeptide binding]; other site
504472008282	PglZ domain; Region: PglZ; pfam08665
504472008283	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472008284	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472008285	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
504472008286	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
504472008287	active site
504472008288	catalytic residues [active]
504472008289	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472008290	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
504472008291	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
504472008292	putative hydrophobic ligand binding site [chemical binding]; other site
504472008293	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472008294	dimerization interface [polypeptide binding]; other site
504472008295	putative DNA binding site [nucleotide binding]; other site
504472008296	putative Zn2+ binding site [ion binding]; other site
504472008297	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
504472008298	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
504472008299	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
504472008300	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
504472008301	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
504472008302	catalytic motif [active]
504472008303	Catalytic residue [active]
504472008304	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472008305	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472008306	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472008307	Uncharacterized conserved protein [Function unknown]; Region: COG1262
504472008308	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
504472008309	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
504472008310	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472008311	active site
504472008312	DNA binding site [nucleotide binding]
504472008313	Int/Topo IB signature motif; other site
504472008314	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
504472008315	GIY-YIG motif/motif A; other site
504472008316	active site
504472008317	catalytic site [active]
504472008318	metal binding site [ion binding]; metal-binding site
504472008319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
504472008320	aldehyde dehydrogenase family 7 member; Region: PLN02315
504472008321	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
504472008322	tetrameric interface [polypeptide binding]; other site
504472008323	NAD binding site [chemical binding]; other site
504472008324	catalytic residues [active]
504472008325	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
504472008326	Fasciclin domain; Region: Fasciclin; pfam02469
504472008327	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
504472008328	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472008329	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472008330	DNA binding residues [nucleotide binding]
504472008331	putative anti-sigmaE protein; Provisional; Region: PRK13920
504472008332	Anti-sigma-K factor rskA; Region: RskA; pfam10099
504472008333	methionine sulfoxide reductase B; Provisional; Region: PRK00222
504472008334	SelR domain; Region: SelR; pfam01641
504472008335	Transglycosylase; Region: Transgly; pfam00912
504472008336	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
504472008337	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472008338	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
504472008339	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472008340	putative metal binding site [ion binding]; other site
504472008341	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
504472008342	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
504472008343	MOSC domain; Region: MOSC; pfam03473
504472008344	UGMP family protein; Validated; Region: PRK09604
504472008345	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
504472008346	Family of unknown function (DUF490); Region: DUF490; pfam04357
504472008347	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
504472008348	active site
504472008349	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
504472008350	TIR domain; Region: TIR_2; pfam13676
504472008351	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
504472008352	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
504472008353	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472008354	ATP binding site [chemical binding]; other site
504472008355	putative Mg++ binding site [ion binding]; other site
504472008356	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
504472008357	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
504472008358	Methyltransferase domain; Region: Methyltransf_26; pfam13659
504472008359	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
504472008360	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
504472008361	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
504472008362	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
504472008363	active site
504472008364	transposase/IS protein; Provisional; Region: PRK09183
504472008365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472008366	Walker A motif; other site
504472008367	ATP binding site [chemical binding]; other site
504472008368	Walker B motif; other site
504472008369	arginine finger; other site
504472008370	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472008371	Integrase core domain; Region: rve; pfam00665
504472008372	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
504472008373	active site
504472008374	D5 N terminal like; Region: D5_N; smart00885
504472008375	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
504472008376	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472008377	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
504472008378	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472008379	active site
504472008380	DNA binding site [nucleotide binding]
504472008381	Int/Topo IB signature motif; other site
504472008382	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472008383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008384	dimer interface [polypeptide binding]; other site
504472008385	phosphorylation site [posttranslational modification]
504472008386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008387	ATP binding site [chemical binding]; other site
504472008388	Mg2+ binding site [ion binding]; other site
504472008389	G-X-G motif; other site
504472008390	PAS domain; Region: PAS_9; pfam13426
504472008391	CheB methylesterase; Region: CheB_methylest; pfam01339
504472008392	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
504472008393	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
504472008394	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
504472008395	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472008396	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472008397	putative active site [active]
504472008398	heme pocket [chemical binding]; other site
504472008399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472008400	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472008401	putative active site [active]
504472008402	heme pocket [chemical binding]; other site
504472008403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472008404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008405	dimer interface [polypeptide binding]; other site
504472008406	phosphorylation site [posttranslational modification]
504472008407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008408	ATP binding site [chemical binding]; other site
504472008409	Mg2+ binding site [ion binding]; other site
504472008410	G-X-G motif; other site
504472008411	CheB methylesterase; Region: CheB_methylest; pfam01339
504472008412	LytTr DNA-binding domain; Region: LytTR; smart00850
504472008413	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472008414	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472008415	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
504472008416	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
504472008417	putative ADP-binding pocket [chemical binding]; other site
504472008418	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
504472008419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472008420	active site
504472008421	motif I; other site
504472008422	motif II; other site
504472008423	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472008424	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472008425	putative active site [active]
504472008426	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
504472008427	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
504472008428	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
504472008429	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
504472008430	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
504472008431	active site
504472008432	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472008433	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472008434	putative active site [active]
504472008435	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
504472008436	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
504472008437	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
504472008438	active site
504472008439	catalytic site [active]
504472008440	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
504472008441	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
504472008442	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
504472008443	catalytic site [active]
504472008444	active site
504472008445	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
504472008446	trehalose synthase; Region: treS_nterm; TIGR02456
504472008447	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
504472008448	active site
504472008449	catalytic site [active]
504472008450	Predicted membrane protein [Function unknown]; Region: COG2323
504472008451	Predicted membrane protein [Function unknown]; Region: COG2323
504472008452	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472008453	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472008454	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472008455	N-terminal plug; other site
504472008456	ligand-binding site [chemical binding]; other site
504472008457	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
504472008458	catalytic site [active]
504472008459	Asp-box motif; other site
504472008460	Uncharacterized conserved protein [Function unknown]; Region: COG0327
504472008461	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
504472008462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
504472008463	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
504472008464	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
504472008465	Putative zinc ribbon domain; Region: DUF164; pfam02591
504472008466	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472008467	Phosphoglycerate kinase; Region: PGK; pfam00162
504472008468	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
504472008469	substrate binding site [chemical binding]; other site
504472008470	hinge regions; other site
504472008471	ADP binding site [chemical binding]; other site
504472008472	catalytic site [active]
504472008473	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
504472008474	putative active site [active]
504472008475	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
504472008476	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
504472008477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472008478	S-adenosylmethionine binding site [chemical binding]; other site
504472008479	Cytochrome c; Region: Cytochrom_C; cl11414
504472008480	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
504472008481	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
504472008482	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
504472008483	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472008484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472008485	S-adenosylmethionine binding site [chemical binding]; other site
504472008486	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
504472008487	Prostaglandin dehydrogenases; Region: PGDH; cd05288
504472008488	NAD(P) binding site [chemical binding]; other site
504472008489	substrate binding site [chemical binding]; other site
504472008490	dimer interface [polypeptide binding]; other site
504472008491	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
504472008492	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
504472008493	MarR family; Region: MarR; pfam01047
504472008494	PAS fold; Region: PAS_3; pfam08447
504472008495	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472008496	PAS fold; Region: PAS_7; pfam12860
504472008497	PAS domain S-box; Region: sensory_box; TIGR00229
504472008498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472008499	putative active site [active]
504472008500	heme pocket [chemical binding]; other site
504472008501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472008502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008503	dimer interface [polypeptide binding]; other site
504472008504	phosphorylation site [posttranslational modification]
504472008505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008506	ATP binding site [chemical binding]; other site
504472008507	Mg2+ binding site [ion binding]; other site
504472008508	G-X-G motif; other site
504472008509	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472008510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008511	active site
504472008512	phosphorylation site [posttranslational modification]
504472008513	intermolecular recognition site; other site
504472008514	dimerization interface [polypeptide binding]; other site
504472008515	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
504472008516	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
504472008517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008518	active site
504472008519	phosphorylation site [posttranslational modification]
504472008520	intermolecular recognition site; other site
504472008521	dimerization interface [polypeptide binding]; other site
504472008522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472008523	Walker A motif; other site
504472008524	ATP binding site [chemical binding]; other site
504472008525	Walker B motif; other site
504472008526	arginine finger; other site
504472008527	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
504472008528	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
504472008529	Mg++ binding site [ion binding]; other site
504472008530	putative catalytic motif [active]
504472008531	substrate binding site [chemical binding]; other site
504472008532	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472008533	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
504472008534	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472008535	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472008536	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472008537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008538	active site
504472008539	phosphorylation site [posttranslational modification]
504472008540	intermolecular recognition site; other site
504472008541	dimerization interface [polypeptide binding]; other site
504472008542	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472008543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008544	active site
504472008545	phosphorylation site [posttranslational modification]
504472008546	intermolecular recognition site; other site
504472008547	short chain dehydrogenase; Provisional; Region: PRK06172
504472008548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472008549	NAD(P) binding site [chemical binding]; other site
504472008550	active site
504472008551	Uncharacterized conserved protein [Function unknown]; Region: COG4850
504472008552	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
504472008553	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
504472008554	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
504472008555	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
504472008556	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
504472008557	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472008558	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
504472008559	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472008560	active site
504472008561	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
504472008562	putative active site [active]
504472008563	catalytic residue [active]
504472008564	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
504472008565	hypothetical protein; Provisional; Region: nrdC.11; PHA02603
504472008566	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
504472008567	Protein of unknown function (DUF692); Region: DUF692; cl01263
504472008568	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472008569	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472008570	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472008571	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472008572	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008573	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472008574	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472008575	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008576	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008577	Histidine kinase; Region: His_kinase; pfam06580
504472008578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008579	Response regulator receiver domain; Region: Response_reg; pfam00072
504472008580	active site
504472008581	phosphorylation site [posttranslational modification]
504472008582	intermolecular recognition site; other site
504472008583	dimerization interface [polypeptide binding]; other site
504472008584	LytTr DNA-binding domain; Region: LytTR; smart00850
504472008585	HlyD family secretion protein; Region: HlyD_2; pfam12700
504472008586	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472008587	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472008588	Outer membrane efflux protein; Region: OEP; pfam02321
504472008589	Outer membrane efflux protein; Region: OEP; pfam02321
504472008590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472008591	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
504472008592	dimer interface [polypeptide binding]; other site
504472008593	putative metal binding site [ion binding]; other site
504472008594	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472008595	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472008596	active site
504472008597	catalytic tetrad [active]
504472008598	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
504472008599	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
504472008600	substrate binding [chemical binding]; other site
504472008601	active site
504472008602	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
504472008603	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472008604	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
504472008605	putative substrate binding site [chemical binding]; other site
504472008606	putative ATP binding site [chemical binding]; other site
504472008607	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
504472008608	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472008609	putative substrate translocation pore; other site
504472008610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472008611	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
504472008612	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472008613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472008614	S-adenosylmethionine binding site [chemical binding]; other site
504472008615	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
504472008616	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
504472008617	malonyl-CoA binding site [chemical binding]; other site
504472008618	dimer interface [polypeptide binding]; other site
504472008619	active site
504472008620	product binding site; other site
504472008621	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
504472008622	classical (c) SDRs; Region: SDR_c; cd05233
504472008623	NAD(P) binding site [chemical binding]; other site
504472008624	active site
504472008625	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
504472008626	active site 2 [active]
504472008627	active site 1 [active]
504472008628	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
504472008629	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
504472008630	dimer interface [polypeptide binding]; other site
504472008631	active site
504472008632	Phosphopantetheine attachment site; Region: PP-binding; cl09936
504472008633	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
504472008634	Homeodomain-like domain; Region: HTH_23; pfam13384
504472008635	Winged helix-turn helix; Region: HTH_29; pfam13551
504472008636	Homeodomain-like domain; Region: HTH_32; pfam13565
504472008637	Winged helix-turn helix; Region: HTH_33; pfam13592
504472008638	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472008639	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472008640	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
504472008641	Cupin domain; Region: Cupin_2; pfam07883
504472008642	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
504472008643	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
504472008644	putative ligand binding site [chemical binding]; other site
504472008645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472008646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008647	dimer interface [polypeptide binding]; other site
504472008648	phosphorylation site [posttranslational modification]
504472008649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008650	ATP binding site [chemical binding]; other site
504472008651	Mg2+ binding site [ion binding]; other site
504472008652	G-X-G motif; other site
504472008653	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472008654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008655	active site
504472008656	phosphorylation site [posttranslational modification]
504472008657	intermolecular recognition site; other site
504472008658	dimerization interface [polypeptide binding]; other site
504472008659	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472008660	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472008661	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
504472008662	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
504472008663	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
504472008664	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
504472008665	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
504472008666	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472008667	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472008668	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472008669	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008670	dimer interface [polypeptide binding]; other site
504472008671	phosphorylation site [posttranslational modification]
504472008672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008673	ATP binding site [chemical binding]; other site
504472008674	Mg2+ binding site [ion binding]; other site
504472008675	G-X-G motif; other site
504472008676	MG2 domain; Region: A2M_N; pfam01835
504472008677	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472008678	Alpha-2-macroglobulin family; Region: A2M; pfam00207
504472008679	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
504472008680	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472008681	NAD binding site [chemical binding]; other site
504472008682	active site
504472008683	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
504472008684	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472008685	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472008686	Coenzyme A binding pocket [chemical binding]; other site
504472008687	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
504472008688	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
504472008689	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
504472008690	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
504472008691	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
504472008692	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
504472008693	ATP synthase A chain; Region: ATP-synt_A; cl00413
504472008694	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
504472008695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
504472008696	binding surface
504472008697	TPR motif; other site
504472008698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472008699	TPR motif; other site
504472008700	TPR repeat; Region: TPR_11; pfam13414
504472008701	binding surface
504472008702	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
504472008703	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
504472008704	Transglycosylase; Region: Transgly; pfam00912
504472008705	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
504472008706	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
504472008707	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
504472008708	GIY-YIG motif/motif A; other site
504472008709	active site
504472008710	catalytic site [active]
504472008711	putative DNA binding site [nucleotide binding]; other site
504472008712	metal binding site [ion binding]; metal-binding site
504472008713	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
504472008714	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
504472008715	DNA binding site [nucleotide binding]
504472008716	gliding motility associated protien GldN; Region: GldN; TIGR03523
504472008717	gliding motility associated protien GldN; Region: GldN; TIGR03523
504472008718	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
504472008719	GldM N-terminal domain; Region: GldM_N; pfam12081
504472008720	GldM C-terminal domain; Region: GldM_C; pfam12080
504472008721	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
504472008722	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
504472008723	Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519
504472008724	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
504472008725	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
504472008726	active site
504472008727	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
504472008728	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
504472008729	CoA binding domain; Region: CoA_binding; smart00881
504472008730	CoA-ligase; Region: Ligase_CoA; pfam00549
504472008731	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
504472008732	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
504472008733	active site
504472008734	DNA binding site [nucleotide binding]
504472008735	Int/Topo IB signature motif; other site
504472008736	catalytic residues [active]
504472008737	Predicted membrane protein [Function unknown]; Region: COG2323
504472008738	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
504472008739	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
504472008740	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
504472008741	active site
504472008742	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472008743	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
504472008744	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
504472008745	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472008746	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472008747	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472008748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472008749	DNA-binding site [nucleotide binding]; DNA binding site
504472008750	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
504472008751	putative dimerization interface [polypeptide binding]; other site
504472008752	putative ligand binding site [chemical binding]; other site
504472008753	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472008754	homotrimer interaction site [polypeptide binding]; other site
504472008755	putative active site [active]
504472008756	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472008757	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
504472008758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472008759	Coenzyme A binding pocket [chemical binding]; other site
504472008760	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472008761	Interdomain contacts; other site
504472008762	Cytokine receptor motif; other site
504472008763	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472008764	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
504472008765	putative active site pocket [active]
504472008766	dimerization interface [polypeptide binding]; other site
504472008767	putative catalytic residue [active]
504472008768	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472008769	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472008770	glutamate carboxypeptidase; Reviewed; Region: PRK06133
504472008771	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
504472008772	metal binding site [ion binding]; metal-binding site
504472008773	dimer interface [polypeptide binding]; other site
504472008774	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
504472008775	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
504472008776	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
504472008777	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472008778	metal binding site [ion binding]; metal-binding site
504472008779	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472008780	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472008781	DinB superfamily; Region: DinB_2; pfam12867
504472008782	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
504472008783	ligand binding site [chemical binding]; other site
504472008784	flexible hinge region; other site
504472008785	Purine nucleoside permease (NUP); Region: NUP; pfam06516
504472008786	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472008787	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
504472008788	active site
504472008789	dimerization interface [polypeptide binding]; other site
504472008790	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
504472008791	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
504472008792	conserved cys residue [active]
504472008793	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472008794	RibD C-terminal domain; Region: RibD_C; cl17279
504472008795	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
504472008796	DoxX-like family; Region: DoxX_2; pfam13564
504472008797	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
504472008798	active site
504472008799	Zn binding site [ion binding]; other site
504472008800	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472008801	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472008802	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472008803	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
504472008804	active site clefts [active]
504472008805	zinc binding site [ion binding]; other site
504472008806	dimer interface [polypeptide binding]; other site
504472008807	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
504472008808	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472008809	catalytic loop [active]
504472008810	iron binding site [ion binding]; other site
504472008811	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
504472008812	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472008813	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472008814	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
504472008815	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
504472008816	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472008817	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472008818	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472008819	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472008820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472008821	Coenzyme A binding pocket [chemical binding]; other site
504472008822	Response regulator receiver domain; Region: Response_reg; pfam00072
504472008823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008824	active site
504472008825	phosphorylation site [posttranslational modification]
504472008826	intermolecular recognition site; other site
504472008827	dimerization interface [polypeptide binding]; other site
504472008828	putative hydrolase; Provisional; Region: PRK02113
504472008829	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
504472008830	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
504472008831	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
504472008832	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
504472008833	trmE is a tRNA modification GTPase; Region: trmE; cd04164
504472008834	G1 box; other site
504472008835	GTP/Mg2+ binding site [chemical binding]; other site
504472008836	Switch I region; other site
504472008837	G2 box; other site
504472008838	Switch II region; other site
504472008839	G3 box; other site
504472008840	G4 box; other site
504472008841	G5 box; other site
504472008842	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
504472008843	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472008844	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472008845	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
504472008846	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
504472008847	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
504472008848	Int/Topo IB signature motif; other site
504472008849	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472008850	VirE N-terminal domain; Region: VirE_N; pfam08800
504472008851	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
504472008852	Virulence-associated protein E; Region: VirE; pfam05272
504472008853	transcriptional regulator SirC; Provisional; Region: PRK15044
504472008854	tape measure domain; Region: tape_meas_nterm; TIGR02675
504472008855	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472008856	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472008857	non-specific DNA binding site [nucleotide binding]; other site
504472008858	salt bridge; other site
504472008859	sequence-specific DNA binding site [nucleotide binding]; other site
504472008860	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
504472008861	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472008862	active site
504472008863	DNA binding site [nucleotide binding]
504472008864	Int/Topo IB signature motif; other site
504472008865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472008866	Integrase core domain; Region: rve; pfam00665
504472008867	transposase/IS protein; Provisional; Region: PRK09183
504472008868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472008869	Walker A motif; other site
504472008870	ATP binding site [chemical binding]; other site
504472008871	Walker B motif; other site
504472008872	arginine finger; other site
504472008873	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
504472008874	Catalytic domain of Protein Kinases; Region: PKc; cd00180
504472008875	active site
504472008876	ATP binding site [chemical binding]; other site
504472008877	substrate binding site [chemical binding]; other site
504472008878	activation loop (A-loop); other site
504472008879	AAA ATPase domain; Region: AAA_16; pfam13191
504472008880	Predicted ATPase [General function prediction only]; Region: COG3899
504472008881	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472008882	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
504472008883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008884	dimer interface [polypeptide binding]; other site
504472008885	phosphorylation site [posttranslational modification]
504472008886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008887	ATP binding site [chemical binding]; other site
504472008888	Mg2+ binding site [ion binding]; other site
504472008889	G-X-G motif; other site
504472008890	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472008891	active site
504472008892	catalytic triad [active]
504472008893	oxyanion hole [active]
504472008894	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
504472008895	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472008896	Coenzyme A binding pocket [chemical binding]; other site
504472008897	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
504472008898	MgtE intracellular N domain; Region: MgtE_N; pfam03448
504472008899	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
504472008900	Divalent cation transporter; Region: MgtE; pfam01769
504472008901	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
504472008902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472008903	S-adenosylmethionine binding site [chemical binding]; other site
504472008904	Bacterial Ig-like domain; Region: Big_5; pfam13205
504472008905	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
504472008906	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
504472008907	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
504472008908	catalytic motif [active]
504472008909	Catalytic residue [active]
504472008910	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472008911	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472008912	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472008913	putative active site [active]
504472008914	heme pocket [chemical binding]; other site
504472008915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472008916	putative active site [active]
504472008917	heme pocket [chemical binding]; other site
504472008918	GAF domain; Region: GAF_3; pfam13492
504472008919	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472008920	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472008921	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472008922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472008923	putative active site [active]
504472008924	heme pocket [chemical binding]; other site
504472008925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472008926	dimer interface [polypeptide binding]; other site
504472008927	phosphorylation site [posttranslational modification]
504472008928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472008929	ATP binding site [chemical binding]; other site
504472008930	Mg2+ binding site [ion binding]; other site
504472008931	G-X-G motif; other site
504472008932	Response regulator receiver domain; Region: Response_reg; pfam00072
504472008933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472008934	active site
504472008935	phosphorylation site [posttranslational modification]
504472008936	intermolecular recognition site; other site
504472008937	dimerization interface [polypeptide binding]; other site
504472008938	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
504472008939	putative binding surface; other site
504472008940	active site
504472008941	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472008942	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472008943	FtsX-like permease family; Region: FtsX; pfam02687
504472008944	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472008945	FtsX-like permease family; Region: FtsX; pfam02687
504472008946	Predicted metalloprotease [General function prediction only]; Region: COG2321
504472008947	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
504472008948	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
504472008949	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
504472008950	active site
504472008951	FMN binding site [chemical binding]; other site
504472008952	substrate binding site [chemical binding]; other site
504472008953	homotetramer interface [polypeptide binding]; other site
504472008954	catalytic residue [active]
504472008955	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
504472008956	classical (c) SDRs; Region: SDR_c; cd05233
504472008957	NAD(P) binding site [chemical binding]; other site
504472008958	active site
504472008959	Cupin domain; Region: Cupin_2; pfam07883
504472008960	Cupin domain; Region: Cupin_2; pfam07883
504472008961	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
504472008962	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472008963	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472008964	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472008965	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472008966	NeuB family; Region: NeuB; pfam03102
504472008967	helicase 45; Provisional; Region: PTZ00424
504472008968	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
504472008969	ATP binding site [chemical binding]; other site
504472008970	Mg++ binding site [ion binding]; other site
504472008971	motif III; other site
504472008972	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472008973	nucleotide binding region [chemical binding]; other site
504472008974	ATP-binding site [chemical binding]; other site
504472008975	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
504472008976	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
504472008977	ATP binding site [chemical binding]; other site
504472008978	putative Mg++ binding site [ion binding]; other site
504472008979	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472008980	nucleotide binding region [chemical binding]; other site
504472008981	ATP-binding site [chemical binding]; other site
504472008982	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
504472008983	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
504472008984	ATP binding site [chemical binding]; other site
504472008985	putative Mg++ binding site [ion binding]; other site
504472008986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472008987	nucleotide binding region [chemical binding]; other site
504472008988	ATP-binding site [chemical binding]; other site
504472008989	DbpA RNA binding domain; Region: DbpA; pfam03880
504472008990	cystathionine gamma-synthase; Provisional; Region: PRK08249
504472008991	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
504472008992	homodimer interface [polypeptide binding]; other site
504472008993	substrate-cofactor binding pocket; other site
504472008994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472008995	catalytic residue [active]
504472008996	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
504472008997	isocitrate dehydrogenase; Validated; Region: PRK09222
504472008998	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
504472008999	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
504472009000	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472009001	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
504472009002	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472009003	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472009004	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472009005	DNA binding residues [nucleotide binding]
504472009006	HEAT repeats; Region: HEAT_2; pfam13646
504472009007	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
504472009008	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
504472009009	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
504472009010	dimerization interface [polypeptide binding]; other site
504472009011	metal binding site [ion binding]; metal-binding site
504472009012	amidase; Provisional; Region: PRK08137
504472009013	Amidase; Region: Amidase; pfam01425
504472009014	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
504472009015	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
504472009016	putative metal binding site [ion binding]; other site
504472009017	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
504472009018	Zn binding site [ion binding]; other site
504472009019	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
504472009020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009021	putative substrate translocation pore; other site
504472009022	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
504472009023	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472009024	ATP binding site [chemical binding]; other site
504472009025	putative Mg++ binding site [ion binding]; other site
504472009026	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472009027	nucleotide binding region [chemical binding]; other site
504472009028	ATP-binding site [chemical binding]; other site
504472009029	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
504472009030	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
504472009031	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
504472009032	Transposase IS200 like; Region: Y1_Tnp; cl00848
504472009033	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
504472009034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472009035	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
504472009036	active site
504472009037	Glyco_18 domain; Region: Glyco_18; smart00636
504472009038	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
504472009039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
504472009040	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
504472009041	putative substrate binding site [chemical binding]; other site
504472009042	active site
504472009043	Putative esterase; Region: Esterase; pfam00756
504472009044	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472009045	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
504472009046	Serine hydrolase; Region: Ser_hydrolase; cl17834
504472009047	Cupin domain; Region: Cupin_2; pfam07883
504472009048	Curlin associated repeat; Region: Curlin_rpt; pfam07012
504472009049	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
504472009050	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
504472009051	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472009052	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472009053	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
504472009054	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
504472009055	DinB family; Region: DinB; cl17821
504472009056	DinB superfamily; Region: DinB_2; pfam12867
504472009057	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
504472009058	dimer interface [polypeptide binding]; other site
504472009059	catalytic triad [active]
504472009060	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472009061	Sulfatase; Region: Sulfatase; pfam00884
504472009062	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
504472009063	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
504472009064	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
504472009065	active site
504472009066	Zn binding site [ion binding]; other site
504472009067	DNA helicase, putative; Region: TIGR00376
504472009068	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472009069	ATP binding site [chemical binding]; other site
504472009070	AAA domain; Region: AAA_12; pfam13087
504472009071	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472009072	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472009073	Amidohydrolase; Region: Amidohydro_4; pfam13147
504472009074	active site
504472009075	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472009076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472009077	NAD(P) binding site [chemical binding]; other site
504472009078	active site
504472009079	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
504472009080	DNA-binding site [nucleotide binding]; DNA binding site
504472009081	RNA-binding motif; other site
504472009082	GntP family permease; Region: GntP_permease; pfam02447
504472009083	fructuronate transporter; Provisional; Region: PRK10034; cl15264
504472009084	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472009085	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472009086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472009087	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472009088	DNA binding residues [nucleotide binding]
504472009089	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472009090	FecR protein; Region: FecR; pfam04773
504472009091	Secretin and TonB N terminus short domain; Region: STN; smart00965
504472009092	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472009093	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472009094	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472009095	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472009096	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472009097	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472009098	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472009099	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472009100	Protein of unknown function DUF54; Region: DUF54; cl00585
504472009101	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472009102	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
504472009103	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
504472009104	active site
504472009105	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472009106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472009107	putative active site [active]
504472009108	heme pocket [chemical binding]; other site
504472009109	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472009110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472009111	putative active site [active]
504472009112	heme pocket [chemical binding]; other site
504472009113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009114	dimer interface [polypeptide binding]; other site
504472009115	phosphorylation site [posttranslational modification]
504472009116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009117	ATP binding site [chemical binding]; other site
504472009118	Mg2+ binding site [ion binding]; other site
504472009119	G-X-G motif; other site
504472009120	Uncharacterized conserved protein [Function unknown]; Region: COG3391
504472009121	Phosphoesterase family; Region: Phosphoesterase; pfam04185
504472009122	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
504472009123	Zn2+ binding site [ion binding]; other site
504472009124	Mg2+ binding site [ion binding]; other site
504472009125	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472009126	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472009127	active site
504472009128	metal binding site [ion binding]; metal-binding site
504472009129	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472009130	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472009131	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472009132	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472009133	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472009134	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472009135	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
504472009136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472009137	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472009138	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
504472009139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472009140	motif II; other site
504472009141	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
504472009142	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
504472009143	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
504472009144	NADP binding site [chemical binding]; other site
504472009145	homodimer interface [polypeptide binding]; other site
504472009146	active site
504472009147	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
504472009148	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
504472009149	active site
504472009150	Uncharacterized conserved protein [Function unknown]; Region: COG4938
504472009151	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
504472009152	Protein of unknown function DUF262; Region: DUF262; pfam03235
504472009153	multiple promoter invertase; Provisional; Region: mpi; PRK13413
504472009154	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
504472009155	catalytic residues [active]
504472009156	catalytic nucleophile [active]
504472009157	Presynaptic Site I dimer interface [polypeptide binding]; other site
504472009158	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
504472009159	Synaptic Flat tetramer interface [polypeptide binding]; other site
504472009160	Synaptic Site I dimer interface [polypeptide binding]; other site
504472009161	DNA binding site [nucleotide binding]
504472009162	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
504472009163	DNA-binding interface [nucleotide binding]; DNA binding site
504472009164	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
504472009165	Methyltransferase domain; Region: Methyltransf_26; pfam13659
504472009166	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
504472009167	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
504472009168	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
504472009169	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
504472009170	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
504472009171	PLD-like domain; Region: PLDc_2; pfam13091
504472009172	putative homodimer interface [polypeptide binding]; other site
504472009173	putative active site [active]
504472009174	catalytic site [active]
504472009175	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472009176	ATP binding site [chemical binding]; other site
504472009177	putative Mg++ binding site [ion binding]; other site
504472009178	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472009179	nucleotide binding region [chemical binding]; other site
504472009180	ATP-binding site [chemical binding]; other site
504472009181	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472009182	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472009183	Family description; Region: VCBS; pfam13517
504472009184	Family description; Region: VCBS; pfam13517
504472009185	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472009186	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472009187	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472009188	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472009189	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472009190	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472009191	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472009192	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472009193	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472009194	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472009195	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472009196	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472009197	SusD family; Region: SusD; pfam07980
504472009198	methionine sulfoxide reductase A; Provisional; Region: PRK14054
504472009199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009200	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472009201	putative substrate translocation pore; other site
504472009202	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
504472009203	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
504472009204	putative active site [active]
504472009205	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472009206	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472009207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009208	active site
504472009209	phosphorylation site [posttranslational modification]
504472009210	intermolecular recognition site; other site
504472009211	dimerization interface [polypeptide binding]; other site
504472009212	LytTr DNA-binding domain; Region: LytTR; smart00850
504472009213	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009214	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472009216	binding surface
504472009217	TPR motif; other site
504472009218	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009219	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009220	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
504472009221	Histidine kinase; Region: HisKA_2; pfam07568
504472009222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009223	ATP binding site [chemical binding]; other site
504472009224	Mg2+ binding site [ion binding]; other site
504472009225	G-X-G motif; other site
504472009226	Penicillinase repressor; Region: Pencillinase_R; cl17580
504472009227	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
504472009228	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
504472009229	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
504472009230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
504472009231	Uncharacterized conserved protein [Function unknown]; Region: COG2442
504472009232	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472009233	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472009234	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472009235	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472009236	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472009237	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472009238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009239	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472009240	putative substrate translocation pore; other site
504472009241	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
504472009242	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
504472009243	Predicted membrane protein [Function unknown]; Region: COG3650
504472009244	META domain; Region: META; pfam03724
504472009245	Trehalose utilisation; Region: ThuA; pfam06283
504472009246	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472009247	FOG: PKD repeat [General function prediction only]; Region: COG3291
504472009248	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472009249	Cytochrome c; Region: Cytochrom_C; cl11414
504472009250	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472009251	ligand binding site [chemical binding]; other site
504472009252	metal binding site [ion binding]; metal-binding site
504472009253	AAA domain; Region: AAA_14; pfam13173
504472009254	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
504472009255	GLPGLI family protein; Region: GLPGLI; TIGR01200
504472009256	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472009257	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472009258	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472009259	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
504472009260	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
504472009261	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
504472009262	LabA_like proteins; Region: LabA_like; cd06167
504472009263	putative metal binding site [ion binding]; other site
504472009264	Uncharacterized conserved protein [Function unknown]; Region: COG1432
504472009265	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
504472009266	RNA-binding motif; other site
504472009267	DNA-binding site [nucleotide binding]; DNA binding site
504472009268	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
504472009269	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472009270	active site
504472009271	motif I; other site
504472009272	motif II; other site
504472009273	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
504472009274	putative active site pocket [active]
504472009275	4-fold oligomerization interface [polypeptide binding]; other site
504472009276	metal binding residues [ion binding]; metal-binding site
504472009277	3-fold/trimer interface [polypeptide binding]; other site
504472009278	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
504472009279	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
504472009280	putative acyl-acceptor binding pocket; other site
504472009281	Predicted amidohydrolase [General function prediction only]; Region: COG0388
504472009282	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
504472009283	putative active site [active]
504472009284	catalytic triad [active]
504472009285	putative dimer interface [polypeptide binding]; other site
504472009286	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
504472009287	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
504472009288	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
504472009289	active site
504472009290	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
504472009291	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
504472009292	NADP binding site [chemical binding]; other site
504472009293	homopentamer interface [polypeptide binding]; other site
504472009294	substrate binding site [chemical binding]; other site
504472009295	active site
504472009296	Protein of unknown function, DUF486; Region: DUF486; cl01236
504472009297	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472009298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472009299	dimerization interface [polypeptide binding]; other site
504472009300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009301	dimer interface [polypeptide binding]; other site
504472009302	phosphorylation site [posttranslational modification]
504472009303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009304	ATP binding site [chemical binding]; other site
504472009305	Mg2+ binding site [ion binding]; other site
504472009306	G-X-G motif; other site
504472009307	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472009308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009309	active site
504472009310	phosphorylation site [posttranslational modification]
504472009311	intermolecular recognition site; other site
504472009312	dimerization interface [polypeptide binding]; other site
504472009313	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472009314	DNA binding site [nucleotide binding]
504472009315	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
504472009316	active site
504472009317	catalytic residues [active]
504472009318	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
504472009319	proline aminopeptidase P II; Provisional; Region: PRK10879
504472009320	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
504472009321	active site
504472009322	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472009323	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472009324	CotH protein; Region: CotH; pfam08757
504472009325	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472009326	Fic family protein [Function unknown]; Region: COG3177
504472009327	Fic/DOC family; Region: Fic; pfam02661
504472009328	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
504472009329	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472009330	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
504472009331	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
504472009332	ATP binding site [chemical binding]; other site
504472009333	substrate interface [chemical binding]; other site
504472009334	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472009335	active site residue [active]
504472009336	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
504472009337	tetramerization interface [polypeptide binding]; other site
504472009338	active site
504472009339	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
504472009340	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
504472009341	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
504472009342	active site
504472009343	nucleotide binding site [chemical binding]; other site
504472009344	HIGH motif; other site
504472009345	KMSKS motif; other site
504472009346	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
504472009347	Membrane protein of unknown function; Region: DUF360; pfam04020
504472009348	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472009349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472009350	S-adenosylmethionine binding site [chemical binding]; other site
504472009351	amino acid transporter; Region: 2A0306; TIGR00909
504472009352	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
504472009353	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
504472009354	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
504472009355	Walker A/P-loop; other site
504472009356	ATP binding site [chemical binding]; other site
504472009357	Q-loop/lid; other site
504472009358	ABC transporter signature motif; other site
504472009359	Walker B; other site
504472009360	D-loop; other site
504472009361	H-loop/switch region; other site
504472009362	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
504472009363	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
504472009364	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
504472009365	active site
504472009366	dimer interface [polypeptide binding]; other site
504472009367	metal binding site [ion binding]; metal-binding site
504472009368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009369	putative substrate translocation pore; other site
504472009370	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
504472009371	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472009372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472009373	homodimer interface [polypeptide binding]; other site
504472009374	catalytic residue [active]
504472009375	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472009376	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472009377	putative active site [active]
504472009378	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472009379	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472009380	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472009381	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
504472009382	homodimer interface [polypeptide binding]; other site
504472009383	metal binding site [ion binding]; metal-binding site
504472009384	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
504472009385	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472009386	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
504472009387	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472009388	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472009389	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
504472009390	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
504472009391	prenyltransferase; Reviewed; Region: ubiA; PRK12872
504472009392	UbiA prenyltransferase family; Region: UbiA; pfam01040
504472009393	MerC mercury resistance protein; Region: MerC; pfam03203
504472009394	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472009395	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472009396	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472009397	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472009398	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
504472009399	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
504472009400	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472009401	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
504472009402	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
504472009403	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
504472009404	substrate binding site [chemical binding]; other site
504472009405	multimerization interface [polypeptide binding]; other site
504472009406	ATP binding site [chemical binding]; other site
504472009407	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
504472009408	thiamine phosphate binding site [chemical binding]; other site
504472009409	active site
504472009410	pyrophosphate binding site [ion binding]; other site
504472009411	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
504472009412	dimer interface [polypeptide binding]; other site
504472009413	substrate binding site [chemical binding]; other site
504472009414	ATP binding site [chemical binding]; other site
504472009415	Putative transcription activator [Transcription]; Region: TenA; COG0819
504472009416	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472009417	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
504472009418	Cupin domain; Region: Cupin_2; pfam07883
504472009419	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472009420	Cupin domain; Region: Cupin_2; cl17218
504472009421	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472009422	SnoaL-like domain; Region: SnoaL_3; pfam13474
504472009423	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
504472009424	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472009425	Protein of unknown function (DUF419); Region: DUF419; pfam04237
504472009426	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472009427	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472009428	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472009429	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
504472009430	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
504472009431	active site
504472009432	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
504472009433	putative active site [active]
504472009434	catalytic site [active]
504472009435	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
504472009436	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
504472009437	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472009438	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472009439	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
504472009440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472009441	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
504472009442	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472009443	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472009444	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472009445	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
504472009446	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
504472009447	dimer interface [polypeptide binding]; other site
504472009448	active site
504472009449	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
504472009450	catalytic residues [active]
504472009451	substrate binding site [chemical binding]; other site
504472009452	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472009453	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
504472009454	NAD binding site [chemical binding]; other site
504472009455	putative substrate binding site 2 [chemical binding]; other site
504472009456	putative substrate binding site 1 [chemical binding]; other site
504472009457	active site
504472009458	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
504472009459	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
504472009460	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
504472009461	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
504472009462	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
504472009463	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
504472009464	active site
504472009465	Predicted membrane protein [Function unknown]; Region: COG2261
504472009466	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
504472009467	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
504472009468	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472009469	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
504472009470	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
504472009471	dimer interaction site [polypeptide binding]; other site
504472009472	substrate-binding tunnel; other site
504472009473	active site
504472009474	catalytic site [active]
504472009475	substrate binding site [chemical binding]; other site
504472009476	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
504472009477	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
504472009478	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472009479	catalytic residue [active]
504472009480	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
504472009481	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
504472009482	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
504472009483	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
504472009484	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
504472009485	Cation efflux family; Region: Cation_efflux; pfam01545
504472009486	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
504472009487	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
504472009488	NAD binding site [chemical binding]; other site
504472009489	substrate binding site [chemical binding]; other site
504472009490	catalytic Zn binding site [ion binding]; other site
504472009491	tetramer interface [polypeptide binding]; other site
504472009492	structural Zn binding site [ion binding]; other site
504472009493	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
504472009494	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
504472009495	putative substrate binding site [chemical binding]; other site
504472009496	putative ATP binding site [chemical binding]; other site
504472009497	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009498	Ligand Binding Site [chemical binding]; other site
504472009499	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009500	Ligand Binding Site [chemical binding]; other site
504472009501	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009502	Ligand Binding Site [chemical binding]; other site
504472009503	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009504	Ligand Binding Site [chemical binding]; other site
504472009505	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
504472009506	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
504472009507	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472009508	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472009509	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472009510	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
504472009511	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009512	Ligand Binding Site [chemical binding]; other site
504472009513	Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589
504472009514	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
504472009515	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
504472009516	putative ligand binding site [chemical binding]; other site
504472009517	putative NAD binding site [chemical binding]; other site
504472009518	catalytic site [active]
504472009519	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472009520	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
504472009521	Response regulator receiver domain; Region: Response_reg; pfam00072
504472009522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009523	active site
504472009524	phosphorylation site [posttranslational modification]
504472009525	intermolecular recognition site; other site
504472009526	dimerization interface [polypeptide binding]; other site
504472009527	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472009528	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
504472009529	ligand binding site [chemical binding]; other site
504472009530	flexible hinge region; other site
504472009531	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
504472009532	putative switch regulator; other site
504472009533	non-specific DNA interactions [nucleotide binding]; other site
504472009534	DNA binding site [nucleotide binding]
504472009535	sequence specific DNA binding site [nucleotide binding]; other site
504472009536	putative cAMP binding site [chemical binding]; other site
504472009537	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472009538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472009539	putative active site [active]
504472009540	heme pocket [chemical binding]; other site
504472009541	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009542	dimer interface [polypeptide binding]; other site
504472009543	phosphorylation site [posttranslational modification]
504472009544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009545	ATP binding site [chemical binding]; other site
504472009546	Mg2+ binding site [ion binding]; other site
504472009547	G-X-G motif; other site
504472009548	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472009549	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
504472009550	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
504472009551	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472009552	Soluble P-type ATPase [General function prediction only]; Region: COG4087
504472009553	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
504472009554	Family description; Region: DsbD_2; pfam13386
504472009555	FixH; Region: FixH; pfam05751
504472009556	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
504472009557	4Fe-4S binding domain; Region: Fer4_5; pfam12801
504472009558	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
504472009559	Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506
504472009560	Cytochrome c; Region: Cytochrom_C; pfam00034
504472009561	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
504472009562	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
504472009563	Low-spin heme binding site [chemical binding]; other site
504472009564	Putative water exit pathway; other site
504472009565	Binuclear center (active site) [active]
504472009566	Putative proton exit pathway; other site
504472009567	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
504472009568	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
504472009569	Fatty acid desaturase; Region: FA_desaturase; pfam00487
504472009570	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
504472009571	putative di-iron ligands [ion binding]; other site
504472009572	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
504472009573	Protein of unknown function (DUF418); Region: DUF418; cl12135
504472009574	Protein of unknown function (DUF418); Region: DUF418; pfam04235
504472009575	Predicted membrane protein [Function unknown]; Region: COG2311
504472009576	Protein of unknown function (DUF418); Region: DUF418; cl12135
504472009577	Protein of unknown function (DUF418); Region: DUF418; pfam04235
504472009578	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
504472009579	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
504472009580	active site
504472009581	catalytic site [active]
504472009582	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
504472009583	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
504472009584	Heavy-metal-associated domain; Region: HMA; pfam00403
504472009585	metal-binding site [ion binding]
504472009586	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472009587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472009588	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009589	Ligand Binding Site [chemical binding]; other site
504472009590	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009591	Ligand Binding Site [chemical binding]; other site
504472009592	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
504472009593	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472009594	FeS/SAM binding site; other site
504472009595	HemN C-terminal domain; Region: HemN_C; pfam06969
504472009596	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
504472009597	CAAX protease self-immunity; Region: Abi; pfam02517
504472009598	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009599	Ligand Binding Site [chemical binding]; other site
504472009600	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472009601	Ligand Binding Site [chemical binding]; other site
504472009602	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
504472009603	Zn binding site [ion binding]; other site
504472009604	Peptidase family C69; Region: Peptidase_C69; cl17793
504472009605	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
504472009606	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
504472009607	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
504472009608	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
504472009609	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
504472009610	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472009611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009612	dimer interface [polypeptide binding]; other site
504472009613	phosphorylation site [posttranslational modification]
504472009614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009615	ATP binding site [chemical binding]; other site
504472009616	Mg2+ binding site [ion binding]; other site
504472009617	G-X-G motif; other site
504472009618	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
504472009619	Walker A motif; other site
504472009620	ATP binding site [chemical binding]; other site
504472009621	Walker B motif; other site
504472009622	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
504472009623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472009624	binding surface
504472009625	TPR motif; other site
504472009626	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
504472009627	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472009628	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472009629	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472009630	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472009631	ligand binding site [chemical binding]; other site
504472009632	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
504472009633	conserved repeat domain; Region: B_ant_repeat; TIGR01451
504472009634	Cna protein B-type domain; Region: Cna_B; pfam05738
504472009635	conserved repeat domain; Region: B_ant_repeat; TIGR01451
504472009636	conserved repeat domain; Region: B_ant_repeat; TIGR01451
504472009637	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472009638	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
504472009639	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472009640	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
504472009641	cytidylate kinase; Provisional; Region: cmk; PRK00023
504472009642	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
504472009643	CMP-binding site; other site
504472009644	The sites determining sugar specificity; other site
504472009645	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
504472009646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472009647	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472009648	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472009649	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472009650	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
504472009651	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
504472009652	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
504472009653	Histidine kinase; Region: His_kinase; pfam06580
504472009654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009655	ATP binding site [chemical binding]; other site
504472009656	Mg2+ binding site [ion binding]; other site
504472009657	G-X-G motif; other site
504472009658	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472009659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009660	active site
504472009661	phosphorylation site [posttranslational modification]
504472009662	intermolecular recognition site; other site
504472009663	dimerization interface [polypeptide binding]; other site
504472009664	LytTr DNA-binding domain; Region: LytTR; smart00850
504472009665	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
504472009666	putative rRNA binding site [nucleotide binding]; other site
504472009667	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
504472009668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009669	putative substrate translocation pore; other site
504472009670	POT family; Region: PTR2; cl17359
504472009671	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472009672	Predicted transcriptional regulators [Transcription]; Region: COG1510
504472009673	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
504472009674	putative DNA binding site [nucleotide binding]; other site
504472009675	putative Zn2+ binding site [ion binding]; other site
504472009676	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472009677	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472009678	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472009679	Integrase core domain; Region: rve; pfam00665
504472009680	Integrase core domain; Region: rve_3; pfam13683
504472009681	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
504472009682	putative ABC transporter; Region: ycf24; CHL00085
504472009683	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
504472009684	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
504472009685	excinuclease ABC subunit B; Provisional; Region: PRK05298
504472009686	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472009687	ATP binding site [chemical binding]; other site
504472009688	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472009689	nucleotide binding region [chemical binding]; other site
504472009690	ATP-binding site [chemical binding]; other site
504472009691	Ultra-violet resistance protein B; Region: UvrB; pfam12344
504472009692	UvrB/uvrC motif; Region: UVR; pfam02151
504472009693	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472009694	Putative esterase; Region: Esterase; pfam00756
504472009695	S-formylglutathione hydrolase; Region: PLN02442
504472009696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
504472009697	Response regulator receiver domain; Region: Response_reg; pfam00072
504472009698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009699	active site
504472009700	phosphorylation site [posttranslational modification]
504472009701	intermolecular recognition site; other site
504472009702	dimerization interface [polypeptide binding]; other site
504472009703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472009704	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472009705	Walker A motif; other site
504472009706	ATP binding site [chemical binding]; other site
504472009707	Walker B motif; other site
504472009708	arginine finger; other site
504472009709	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472009710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009711	ATP binding site [chemical binding]; other site
504472009712	Mg2+ binding site [ion binding]; other site
504472009713	G-X-G motif; other site
504472009714	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
504472009715	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
504472009716	tRNA; other site
504472009717	putative tRNA binding site [nucleotide binding]; other site
504472009718	putative NADP binding site [chemical binding]; other site
504472009719	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
504472009720	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
504472009721	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
504472009722	Na binding site [ion binding]; other site
504472009723	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
504472009724	active site
504472009725	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
504472009726	dimer interface [polypeptide binding]; other site
504472009727	non-prolyl cis peptide bond; other site
504472009728	insertion regions; other site
504472009729	sulfite oxidase; Provisional; Region: PLN00177
504472009730	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
504472009731	Moco binding site; other site
504472009732	metal coordination site [ion binding]; other site
504472009733	dimerization interface [polypeptide binding]; other site
504472009734	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
504472009735	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
504472009736	Ca binding site [ion binding]; other site
504472009737	active site
504472009738	catalytic site [active]
504472009739	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
504472009740	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472009741	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
504472009742	NADH dehydrogenase subunit B; Validated; Region: PRK06411
504472009743	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472009744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009745	putative substrate translocation pore; other site
504472009746	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472009747	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
504472009748	putative transporter; Provisional; Region: PRK10484
504472009749	Na binding site [ion binding]; other site
504472009750	substrate binding site [chemical binding]; other site
504472009751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009752	putative substrate translocation pore; other site
504472009753	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472009754	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472009755	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472009756	FtsX-like permease family; Region: FtsX; pfam02687
504472009757	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472009758	FtsX-like permease family; Region: FtsX; pfam02687
504472009759	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472009760	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472009761	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472009762	short chain dehydrogenase; Provisional; Region: PRK06914
504472009763	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472009764	NADP binding site [chemical binding]; other site
504472009765	active site
504472009766	steroid binding site; other site
504472009767	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
504472009768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472009769	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
504472009770	Coenzyme A binding pocket [chemical binding]; other site
504472009771	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
504472009772	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472009773	P-loop; other site
504472009774	Magnesium ion binding site [ion binding]; other site
504472009775	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472009776	Magnesium ion binding site [ion binding]; other site
504472009777	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
504472009778	putative active site [active]
504472009779	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472009780	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472009781	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472009782	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
504472009783	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472009784	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472009785	DNA binding residues [nucleotide binding]
504472009786	multiple promoter invertase; Provisional; Region: mpi; PRK13413
504472009787	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
504472009788	catalytic residues [active]
504472009789	catalytic nucleophile [active]
504472009790	Presynaptic Site I dimer interface [polypeptide binding]; other site
504472009791	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
504472009792	Synaptic Flat tetramer interface [polypeptide binding]; other site
504472009793	Synaptic Site I dimer interface [polypeptide binding]; other site
504472009794	DNA binding site [nucleotide binding]
504472009795	Sensors of blue-light using FAD; Region: BLUF; pfam04940
504472009796	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
504472009797	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
504472009798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472009799	ABC transporter signature motif; other site
504472009800	Walker B; other site
504472009801	D-loop; other site
504472009802	H-loop/switch region; other site
504472009803	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
504472009804	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
504472009805	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472009806	NAD binding site [chemical binding]; other site
504472009807	catalytic Zn binding site [ion binding]; other site
504472009808	structural Zn binding site [ion binding]; other site
504472009809	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
504472009810	Predicted integral membrane protein [Function unknown]; Region: COG5637
504472009811	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
504472009812	putative hydrophobic ligand binding site [chemical binding]; other site
504472009813	Major royal jelly protein; Region: MRJP; pfam03022
504472009814	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
504472009815	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472009816	NAD binding site [chemical binding]; other site
504472009817	catalytic Zn binding site [ion binding]; other site
504472009818	structural Zn binding site [ion binding]; other site
504472009819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
504472009820	Histidine kinase; Region: HisKA_2; pfam07568
504472009821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009822	ATP binding site [chemical binding]; other site
504472009823	Mg2+ binding site [ion binding]; other site
504472009824	G-X-G motif; other site
504472009825	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472009826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009827	active site
504472009828	phosphorylation site [posttranslational modification]
504472009829	intermolecular recognition site; other site
504472009830	dimerization interface [polypeptide binding]; other site
504472009831	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
504472009832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472009833	Walker A motif; other site
504472009834	ATP binding site [chemical binding]; other site
504472009835	Walker B motif; other site
504472009836	arginine finger; other site
504472009837	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
504472009838	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472009839	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472009840	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
504472009841	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
504472009842	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472009843	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
504472009844	nucleophilic elbow; other site
504472009845	catalytic triad; other site
504472009846	PIN domain; Region: PIN_3; pfam13470
504472009847	TetR family transcriptional regulator; Provisional; Region: PRK14996
504472009848	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472009849	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
504472009850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472009851	NAD(P) binding site [chemical binding]; other site
504472009852	active site
504472009853	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472009854	TAP-like protein; Region: Abhydrolase_4; pfam08386
504472009855	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
504472009856	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
504472009857	putative NAD(P) binding site [chemical binding]; other site
504472009858	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472009859	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
504472009860	RES domain; Region: RES; pfam08808
504472009861	Transposase; Region: HTH_Tnp_1; pfam01527
504472009862	putative transposase OrfB; Reviewed; Region: PHA02517
504472009863	HTH-like domain; Region: HTH_21; pfam13276
504472009864	Integrase core domain; Region: rve; pfam00665
504472009865	Integrase core domain; Region: rve_3; pfam13683
504472009866	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
504472009867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472009868	putative substrate translocation pore; other site
504472009869	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472009870	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472009871	transposase/IS protein; Provisional; Region: PRK09183
504472009872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472009873	Walker A motif; other site
504472009874	ATP binding site [chemical binding]; other site
504472009875	Walker B motif; other site
504472009876	arginine finger; other site
504472009877	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472009878	Integrase core domain; Region: rve; pfam00665
504472009879	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472009880	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472009881	FtsX-like permease family; Region: FtsX; pfam02687
504472009882	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472009883	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472009884	FtsX-like permease family; Region: FtsX; pfam02687
504472009885	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472009886	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472009887	RES domain; Region: RES; pfam08808
504472009888	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
504472009889	GSCFA family; Region: GSCFA; pfam08885
504472009890	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
504472009891	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
504472009892	active site
504472009893	homodimer interface [polypeptide binding]; other site
504472009894	SAM binding site [chemical binding]; other site
504472009895	Homeodomain-like domain; Region: HTH_23; pfam13384
504472009896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009897	active site
504472009898	phosphorylation site [posttranslational modification]
504472009899	intermolecular recognition site; other site
504472009900	dimerization interface [polypeptide binding]; other site
504472009901	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
504472009902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472009903	PAS fold; Region: PAS_3; pfam08447
504472009904	putative active site [active]
504472009905	heme pocket [chemical binding]; other site
504472009906	PAS fold; Region: PAS_4; pfam08448
504472009907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009908	dimer interface [polypeptide binding]; other site
504472009909	phosphorylation site [posttranslational modification]
504472009910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009911	ATP binding site [chemical binding]; other site
504472009912	Mg2+ binding site [ion binding]; other site
504472009913	G-X-G motif; other site
504472009914	PAS fold; Region: PAS_4; pfam08448
504472009915	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472009916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009917	dimer interface [polypeptide binding]; other site
504472009918	phosphorylation site [posttranslational modification]
504472009919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009920	ATP binding site [chemical binding]; other site
504472009921	G-X-G motif; other site
504472009922	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009923	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472009925	binding surface
504472009926	TPR motif; other site
504472009927	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472009928	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009929	dimer interface [polypeptide binding]; other site
504472009930	phosphorylation site [posttranslational modification]
504472009931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009932	ATP binding site [chemical binding]; other site
504472009933	Mg2+ binding site [ion binding]; other site
504472009934	G-X-G motif; other site
504472009935	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472009936	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472009937	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472009938	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
504472009939	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
504472009940	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472009941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472009942	active site
504472009943	phosphorylation site [posttranslational modification]
504472009944	intermolecular recognition site; other site
504472009945	dimerization interface [polypeptide binding]; other site
504472009946	LytTr DNA-binding domain; Region: LytTR; smart00850
504472009947	Histidine kinase; Region: His_kinase; pfam06580
504472009948	PAS fold; Region: PAS_3; pfam08447
504472009949	PAS fold; Region: PAS_4; pfam08448
504472009950	PAS domain; Region: PAS_9; pfam13426
504472009951	PAS fold; Region: PAS; pfam00989
504472009952	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472009953	PAS domain; Region: PAS_9; pfam13426
504472009954	putative active site [active]
504472009955	heme pocket [chemical binding]; other site
504472009956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472009957	dimer interface [polypeptide binding]; other site
504472009958	phosphorylation site [posttranslational modification]
504472009959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472009960	ATP binding site [chemical binding]; other site
504472009961	Mg2+ binding site [ion binding]; other site
504472009962	G-X-G motif; other site
504472009963	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
504472009964	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
504472009965	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
504472009966	putative active site [active]
504472009967	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
504472009968	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472009969	NADP binding site [chemical binding]; other site
504472009970	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472009971	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472009972	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
504472009973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472009974	NAD(P) binding site [chemical binding]; other site
504472009975	active site
504472009976	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472009977	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472009978	Predicted peptidase [General function prediction only]; Region: COG4099
504472009979	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472009980	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472009981	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472009982	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472009983	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
504472009984	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472009985	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472009986	catalytic residues [active]
504472009987	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472009988	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472009989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
504472009990	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472009991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472009992	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472009993	NAD(P) binding site [chemical binding]; other site
504472009994	active site
504472009995	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
504472009996	active site
504472009997	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472009998	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472009999	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010000	Cupin domain; Region: Cupin_2; pfam07883
504472010001	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010002	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010003	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472010004	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
504472010005	NADP binding site [chemical binding]; other site
504472010006	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
504472010007	putative heme binding pocket [chemical binding]; other site
504472010008	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472010009	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472010010	FtsX-like permease family; Region: FtsX; pfam02687
504472010011	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472010012	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472010013	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472010014	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472010015	FtsX-like permease family; Region: FtsX; pfam02687
504472010016	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472010017	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
504472010018	FAD binding pocket [chemical binding]; other site
504472010019	conserved FAD binding motif [chemical binding]; other site
504472010020	phosphate binding motif [ion binding]; other site
504472010021	beta-alpha-beta structure motif; other site
504472010022	NAD binding pocket [chemical binding]; other site
504472010023	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472010024	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010026	RES domain; Region: RES; cl02411
504472010027	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472010028	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472010029	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472010030	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
504472010031	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472010032	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472010033	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472010034	FtsX-like permease family; Region: FtsX; pfam02687
504472010035	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472010036	FtsX-like permease family; Region: FtsX; pfam02687
504472010037	Chromate transporter; Region: Chromate_transp; pfam02417
504472010038	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
504472010039	Chromate transporter; Region: Chromate_transp; pfam02417
504472010040	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
504472010041	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472010042	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472010043	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010044	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
504472010045	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
504472010046	putative NAD(P) binding site [chemical binding]; other site
504472010047	putative substrate binding site [chemical binding]; other site
504472010048	catalytic Zn binding site [ion binding]; other site
504472010049	structural Zn binding site [ion binding]; other site
504472010050	dimer interface [polypeptide binding]; other site
504472010051	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
504472010052	Methyltransferase domain; Region: Methyltransf_18; pfam12847
504472010053	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472010054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472010055	putative substrate translocation pore; other site
504472010056	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
504472010057	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472010058	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010059	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010060	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472010061	Integrase core domain; Region: rve; pfam00665
504472010062	transposase/IS protein; Provisional; Region: PRK09183
504472010063	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472010064	Walker A motif; other site
504472010065	ATP binding site [chemical binding]; other site
504472010066	Walker B motif; other site
504472010067	arginine finger; other site
504472010068	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
504472010069	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
504472010070	AMP-binding enzyme; Region: AMP-binding; pfam00501
504472010071	acyl-activating enzyme (AAE) consensus motif; other site
504472010072	AMP binding site [chemical binding]; other site
504472010073	active site
504472010074	CoA binding site [chemical binding]; other site
504472010075	Thioesterase domain; Region: Thioesterase; pfam00975
504472010076	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
504472010077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472010078	binding surface
504472010079	TPR motif; other site
504472010080	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472010081	binding surface
504472010082	TPR motif; other site
504472010083	TPR repeat; Region: TPR_11; pfam13414
504472010084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472010085	binding surface
504472010086	TPR motif; other site
504472010087	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472010088	PAS domain; Region: PAS_9; pfam13426
504472010089	putative active site [active]
504472010090	heme pocket [chemical binding]; other site
504472010091	PAS domain; Region: PAS_9; pfam13426
504472010092	Fic family protein [Function unknown]; Region: COG3177
504472010093	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
504472010094	Fic/DOC family; Region: Fic; pfam02661
504472010095	Immunoglobulin domain; Region: Ig; cl11960
504472010096	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472010097	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472010098	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472010099	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
504472010100	NADP binding site [chemical binding]; other site
504472010101	putative substrate binding site [chemical binding]; other site
504472010102	active site
504472010103	Pirin-related protein [General function prediction only]; Region: COG1741
504472010104	Pirin; Region: Pirin; pfam02678
504472010105	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
504472010106	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
504472010107	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
504472010108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472010109	Coenzyme A binding pocket [chemical binding]; other site
504472010110	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472010111	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
504472010112	substrate binding pocket [chemical binding]; other site
504472010113	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472010114	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
504472010115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472010116	NAD(P) binding site [chemical binding]; other site
504472010117	active site
504472010118	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472010119	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
504472010120	NmrA-like family; Region: NmrA; pfam05368
504472010121	NADP binding site [chemical binding]; other site
504472010122	active site
504472010123	regulatory binding site [polypeptide binding]; other site
504472010124	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472010125	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472010126	ligand binding site [chemical binding]; other site
504472010127	NHL repeat; Region: NHL; pfam01436
504472010128	SnoaL-like domain; Region: SnoaL_3; pfam13474
504472010129	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472010130	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010131	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472010132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472010133	NAD(P) binding site [chemical binding]; other site
504472010134	active site
504472010135	RES domain; Region: RES; cl02411
504472010136	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
504472010137	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
504472010138	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472010139	PAS fold; Region: PAS_3; pfam08447
504472010140	putative active site [active]
504472010141	heme pocket [chemical binding]; other site
504472010142	PAS fold; Region: PAS_4; pfam08448
504472010143	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472010144	PAS fold; Region: PAS_3; pfam08447
504472010145	putative active site [active]
504472010146	heme pocket [chemical binding]; other site
504472010147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472010148	dimer interface [polypeptide binding]; other site
504472010149	phosphorylation site [posttranslational modification]
504472010150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472010151	ATP binding site [chemical binding]; other site
504472010152	Mg2+ binding site [ion binding]; other site
504472010153	G-X-G motif; other site
504472010154	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472010155	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472010156	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472010157	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472010158	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010160	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
504472010161	GAF domain; Region: GAF; pfam01590
504472010162	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472010163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472010164	PAS domain; Region: PAS_9; pfam13426
504472010165	putative active site [active]
504472010166	heme pocket [chemical binding]; other site
504472010167	PAS domain S-box; Region: sensory_box; TIGR00229
504472010168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472010169	putative active site [active]
504472010170	heme pocket [chemical binding]; other site
504472010171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472010172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472010173	dimer interface [polypeptide binding]; other site
504472010174	phosphorylation site [posttranslational modification]
504472010175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472010176	ATP binding site [chemical binding]; other site
504472010177	Mg2+ binding site [ion binding]; other site
504472010178	G-X-G motif; other site
504472010179	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472010180	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472010181	ligand binding site [chemical binding]; other site
504472010182	flexible hinge region; other site
504472010183	EthD domain; Region: EthD; pfam07110
504472010184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472010185	Coenzyme A binding pocket [chemical binding]; other site
504472010186	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472010187	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472010188	ligand binding site [chemical binding]; other site
504472010189	flexible hinge region; other site
504472010190	DoxX-like family; Region: DoxX_2; pfam13564
504472010191	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
504472010192	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
504472010193	NAD(P) binding site [chemical binding]; other site
504472010194	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472010195	DNA-binding interface [nucleotide binding]; DNA binding site
504472010196	Winged helix-turn helix; Region: HTH_29; pfam13551
504472010197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
504472010198	HTH-like domain; Region: HTH_21; pfam13276
504472010199	Integrase core domain; Region: rve; pfam00665
504472010200	Integrase core domain; Region: rve_3; pfam13683
504472010201	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
504472010202	PQQ-like domain; Region: PQQ_2; pfam13360
504472010203	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472010204	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
504472010205	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472010206	active site
504472010207	catalytic triad [active]
504472010208	oxyanion hole [active]
504472010209	amidase; Provisional; Region: PRK08137
504472010210	Amidase; Region: Amidase; pfam01425
504472010211	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
504472010212	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
504472010213	LytTr DNA-binding domain; Region: LytTR; smart00850
504472010214	Right handed beta helix region; Region: Beta_helix; pfam13229
504472010215	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472010216	Response regulator receiver domain; Region: Response_reg; pfam00072
504472010217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472010218	active site
504472010219	phosphorylation site [posttranslational modification]
504472010220	intermolecular recognition site; other site
504472010221	dimerization interface [polypeptide binding]; other site
504472010222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
504472010223	active site
504472010224	phosphorylation site [posttranslational modification]
504472010225	intermolecular recognition site; other site
504472010226	dimerization interface [polypeptide binding]; other site
504472010227	Bacterial sugar transferase; Region: Bac_transf; cl00939
504472010228	Bacterial sugar transferase; Region: Bac_transf; pfam02397
504472010229	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472010230	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
504472010231	Probable Catalytic site; other site
504472010232	metal-binding site
504472010233	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472010234	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
504472010235	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
504472010236	DXD motif; other site
504472010237	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
504472010238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472010239	putative homodimer interface [polypeptide binding]; other site
504472010240	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
504472010241	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
504472010242	trimer interface [polypeptide binding]; other site
504472010243	active site
504472010244	substrate binding site [chemical binding]; other site
504472010245	CoA binding site [chemical binding]; other site
504472010246	FOG: PKD repeat [General function prediction only]; Region: COG3291
504472010247	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472010248	Outer membrane efflux protein; Region: OEP; pfam02321
504472010249	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
504472010250	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472010251	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472010252	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
504472010253	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472010254	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
504472010255	DXD motif; other site
504472010256	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
504472010257	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472010258	DXD motif; other site
504472010259	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
504472010260	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472010261	Disaggregatase related; Region: Disaggr_assoc; pfam08480
504472010262	Right handed beta helix region; Region: Beta_helix; pfam13229
504472010263	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472010264	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
504472010265	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
504472010266	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
504472010267	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472010268	Bifunctional nuclease; Region: DNase-RNase; pfam02577
504472010269	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
504472010270	dimerization interface [polypeptide binding]; other site
504472010271	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
504472010272	ATP binding site [chemical binding]; other site
504472010273	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
504472010274	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
504472010275	HupF/HypC family; Region: HupF_HypC; pfam01455
504472010276	Acylphosphatase; Region: Acylphosphatase; pfam00708
504472010277	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
504472010278	HypF finger; Region: zf-HYPF; pfam07503
504472010279	HypF finger; Region: zf-HYPF; pfam07503
504472010280	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
504472010281	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472010282	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
504472010283	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
504472010284	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
504472010285	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
504472010286	nickel binding site [ion binding]; other site
504472010287	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
504472010288	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
504472010289	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
504472010290	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472010291	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472010292	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
504472010293	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
504472010294	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
504472010295	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472010296	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
504472010297	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
504472010298	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
504472010299	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472010300	active site
504472010301	Fn3 associated; Region: Fn3_assoc; pfam13287
504472010302	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
504472010303	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
504472010304	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
504472010305	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472010306	Fn3 associated; Region: Fn3_assoc; pfam13287
504472010307	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472010308	sugar binding site [chemical binding]; other site
504472010309	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
504472010310	mannonate dehydratase; Region: uxuA; TIGR00695
504472010311	mannonate dehydratase; Region: uxuA; TIGR00695
504472010312	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472010313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472010314	active site
504472010315	phosphorylation site [posttranslational modification]
504472010316	intermolecular recognition site; other site
504472010317	dimerization interface [polypeptide binding]; other site
504472010318	LytTr DNA-binding domain; Region: LytTR; smart00850
504472010319	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472010320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472010321	NAD(P) binding site [chemical binding]; other site
504472010322	active site
504472010323	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
504472010324	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
504472010325	Protein of unknown function (DUF3804); Region: DUF3804; pfam12707
504472010326	SnoaL-like domain; Region: SnoaL_3; pfam13474
504472010327	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
504472010328	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
504472010329	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
504472010330	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
504472010331	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472010332	homotrimer interaction site [polypeptide binding]; other site
504472010333	putative active site [active]
504472010334	Predicted membrane protein [Function unknown]; Region: COG3503
504472010335	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472010336	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472010337	Coenzyme A binding pocket [chemical binding]; other site
504472010338	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
504472010339	Cupin domain; Region: Cupin_2; pfam07883
504472010340	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
504472010341	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472010342	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472010343	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
504472010344	Histidine kinase; Region: HisKA_2; pfam07568
504472010345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472010346	ATP binding site [chemical binding]; other site
504472010347	Mg2+ binding site [ion binding]; other site
504472010348	G-X-G motif; other site
504472010349	Uncharacterized conserved protein [Function unknown]; Region: COG1434
504472010350	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
504472010351	putative active site [active]
504472010352	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
504472010353	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
504472010354	putative metal binding site [ion binding]; other site
504472010355	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472010356	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472010357	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
504472010358	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010359	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010360	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010361	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010362	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010363	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010364	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010365	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010366	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010367	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010368	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
504472010369	HYR domain; Region: HYR; pfam02494
504472010370	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472010371	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472010372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472010373	putative active site [active]
504472010374	heme pocket [chemical binding]; other site
504472010375	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472010376	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472010377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472010378	dimer interface [polypeptide binding]; other site
504472010379	phosphorylation site [posttranslational modification]
504472010380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472010381	ATP binding site [chemical binding]; other site
504472010382	Mg2+ binding site [ion binding]; other site
504472010383	G-X-G motif; other site
504472010384	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
504472010385	Amidase; Region: Amidase; pfam01425
504472010386	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
504472010387	active site
504472010388	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
504472010389	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
504472010390	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
504472010391	ribonuclease P; Reviewed; Region: rnpA; PRK01903
504472010392	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472010393	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
504472010394	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
504472010395	protein binding site [polypeptide binding]; other site
504472010396	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
504472010397	Catalytic dyad [active]
504472010398	Histidine kinase; Region: His_kinase; pfam06580
504472010399	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472010400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472010401	active site
504472010402	phosphorylation site [posttranslational modification]
504472010403	intermolecular recognition site; other site
504472010404	dimerization interface [polypeptide binding]; other site
504472010405	LytTr DNA-binding domain; Region: LytTR; smart00850
504472010406	short chain dehydrogenase; Provisional; Region: PRK08263
504472010407	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472010408	NADP binding site [chemical binding]; other site
504472010409	active site
504472010410	steroid binding site; other site
504472010411	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
504472010412	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
504472010413	putative NAD(P) binding site [chemical binding]; other site
504472010414	dimer interface [polypeptide binding]; other site
504472010415	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010416	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010417	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
504472010418	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
504472010419	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
504472010420	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
504472010421	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
504472010422	Cysteine-rich domain; Region: CCG; pfam02754
504472010423	Cysteine-rich domain; Region: CCG; pfam02754
504472010424	topology modulation protein; Reviewed; Region: PRK08118
504472010425	AAA domain; Region: AAA_17; pfam13207
504472010426	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
504472010427	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472010428	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
504472010429	active site
504472010430	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472010431	dimerization interface [polypeptide binding]; other site
504472010432	putative DNA binding site [nucleotide binding]; other site
504472010433	putative Zn2+ binding site [ion binding]; other site
504472010434	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472010435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472010436	S-adenosylmethionine binding site [chemical binding]; other site
504472010437	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
504472010438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472010439	Coenzyme A binding pocket [chemical binding]; other site
504472010440	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
504472010441	Low molecular weight phosphatase family; Region: LMWPc; cd00115
504472010442	active site
504472010443	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
504472010444	arsenical-resistance protein; Region: acr3; TIGR00832
504472010445	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
504472010446	purine nucleoside phosphorylase; Provisional; Region: PRK08202
504472010447	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472010448	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472010449	DNA binding site [nucleotide binding]
504472010450	domain linker motif; other site
504472010451	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472010452	dimerization interface [polypeptide binding]; other site
504472010453	ligand binding site [chemical binding]; other site
504472010454	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472010455	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
504472010456	active site pocket [active]
504472010457	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472010458	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472010459	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472010460	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472010461	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472010462	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472010463	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
504472010464	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
504472010465	metal binding site [ion binding]; metal-binding site
504472010466	substrate binding pocket [chemical binding]; other site
504472010467	galactonate dehydratase; Provisional; Region: PRK14017
504472010468	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
504472010469	metal binding site [ion binding]; metal-binding site
504472010470	substrate binding pocket [chemical binding]; other site
504472010471	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472010472	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472010473	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472010474	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472010475	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472010476	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
504472010477	PQQ-like domain; Region: PQQ_2; pfam13360
504472010478	Trp docking motif [polypeptide binding]; other site
504472010479	putative active site [active]
504472010480	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472010481	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472010482	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472010483	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
504472010484	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
504472010485	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
504472010486	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
504472010487	active site
504472010488	intersubunit interface [polypeptide binding]; other site
504472010489	catalytic residue [active]
504472010490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472010491	D-galactonate transporter; Region: 2A0114; TIGR00893
504472010492	putative substrate translocation pore; other site
504472010493	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
504472010494	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
504472010495	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
504472010496	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
504472010497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472010498	active site
504472010499	FecR protein; Region: FecR; pfam04773
504472010500	Secretin and TonB N terminus short domain; Region: STN; pfam07660
504472010501	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472010502	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472010503	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472010504	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472010505	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472010506	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472010507	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472010508	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472010509	homotrimer interaction site [polypeptide binding]; other site
504472010510	putative active site [active]
504472010511	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
504472010512	putative ligand binding site [chemical binding]; other site
504472010513	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472010514	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472010515	catalytic residue [active]
504472010516	dihydroorotase; Provisional; Region: PRK09237
504472010517	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472010518	active site
504472010519	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472010520	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472010521	Cytochrome c; Region: Cytochrom_C; pfam00034
504472010522	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472010523	homotrimer interaction site [polypeptide binding]; other site
504472010524	putative active site [active]
504472010525	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472010526	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472010527	catalytic residue [active]
504472010528	dihydroorotase; Provisional; Region: PRK09237
504472010529	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472010530	active site
504472010531	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
504472010532	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
504472010533	active site
504472010534	TDP-binding site; other site
504472010535	acceptor substrate-binding pocket; other site
504472010536	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
504472010537	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
504472010538	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
504472010539	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
504472010540	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472010541	active site
504472010542	Fn3 associated; Region: Fn3_assoc; pfam13287
504472010543	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
504472010544	active site
504472010545	catalytic triad [active]
504472010546	oxyanion hole [active]
504472010547	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
504472010548	active site
504472010549	catalytic triad [active]
504472010550	oxyanion hole [active]
504472010551	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472010552	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472010553	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472010554	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472010555	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472010556	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472010557	Family description; Region: VCBS; pfam13517
504472010558	Family description; Region: VCBS; pfam13517
504472010559	Family description; Region: VCBS; pfam13517
504472010560	Family description; Region: VCBS; pfam13517
504472010561	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472010562	Family description; Region: VCBS; pfam13517
504472010563	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
504472010564	Family description; Region: VCBS; pfam13517
504472010565	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472010566	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472010567	DNA binding residues [nucleotide binding]
504472010568	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
504472010569	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472010570	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472010571	Cytochrome c; Region: Cytochrom_C; pfam00034
504472010572	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472010573	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
504472010574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472010575	NAD(P) binding site [chemical binding]; other site
504472010576	active site
504472010577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472010578	D-galactonate transporter; Region: 2A0114; TIGR00893
504472010579	putative substrate translocation pore; other site
504472010580	Cupin domain; Region: Cupin_2; cl17218
504472010581	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240
504472010582	putative active site [active]
504472010583	Zn binding site [ion binding]; other site
504472010584	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472010585	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472010586	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472010587	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472010588	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472010589	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472010590	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472010591	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472010592	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
504472010593	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
504472010594	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472010595	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472010596	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472010597	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
504472010598	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
504472010599	NAD binding site [chemical binding]; other site
504472010600	homodimer interface [polypeptide binding]; other site
504472010601	homotetramer interface [polypeptide binding]; other site
504472010602	active site
504472010603	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
504472010604	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472010605	motif II; other site
504472010606	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
504472010607	dimer interface [polypeptide binding]; other site
504472010608	[2Fe-2S] cluster binding site [ion binding]; other site
504472010609	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472010610	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472010611	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472010612	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472010613	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
504472010614	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472010615	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
504472010616	substrate binding pocket [chemical binding]; other site
504472010617	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472010618	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472010619	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472010620	ligand binding site [chemical binding]; other site
504472010621	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472010622	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472010623	DNA binding site [nucleotide binding]
504472010624	domain linker motif; other site
504472010625	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472010626	dimerization interface [polypeptide binding]; other site
504472010627	ligand binding site [chemical binding]; other site
504472010628	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472010629	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472010630	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472010631	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
504472010632	oligomeric interface; other site
504472010633	putative active site [active]
504472010634	homodimer interface [polypeptide binding]; other site
504472010635	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
504472010636	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472010637	substrate binding pocket [chemical binding]; other site
504472010638	catalytic triad [active]
504472010639	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472010640	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010641	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
504472010642	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472010643	NAD(P) binding site [chemical binding]; other site
504472010644	active site
504472010645	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472010646	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010647	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010648	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472010649	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
504472010650	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472010651	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
504472010652	tetramer interface [polypeptide binding]; other site
504472010653	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
504472010654	C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014
504472010655	tetramer interface [polypeptide binding]; other site
504472010656	active site
504472010657	metal binding site [ion binding]; metal-binding site
504472010658	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
504472010659	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
504472010660	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
504472010661	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
504472010662	NAD binding site [chemical binding]; other site
504472010663	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
504472010664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
504472010665	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472010666	Uncharacterized conserved protein [Function unknown]; Region: COG3538
504472010667	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
504472010668	Trehalose utilisation; Region: ThuA; pfam06283
504472010669	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472010670	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472010671	Cytochrome c; Region: Cytochrom_C; cl11414
504472010672	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472010673	metal binding site [ion binding]; metal-binding site
504472010674	ligand binding site [chemical binding]; other site
504472010675	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
504472010676	active site
504472010677	nucleophile elbow; other site
504472010678	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472010679	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472010680	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472010681	oxidoreductase; Provisional; Region: PRK06128
504472010682	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472010683	NAD(P) binding site [chemical binding]; other site
504472010684	active site
504472010685	NIPSNAP; Region: NIPSNAP; pfam07978
504472010686	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
504472010687	active site
504472010688	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472010689	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
504472010690	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
504472010691	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472010692	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472010693	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472010694	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472010695	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472010696	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472010697	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472010698	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472010699	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010700	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
504472010701	Active Sites [active]
504472010702	HNH endonuclease; Region: HNH_4; pfam13395
504472010703	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
504472010704	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
504472010705	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472010706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472010707	S-adenosylmethionine binding site [chemical binding]; other site
504472010708	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
504472010709	nucleotide binding site/active site [active]
504472010710	HIT family signature motif; other site
504472010711	catalytic residue [active]
504472010712	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
504472010713	PLD-like domain; Region: PLDc_2; pfam13091
504472010714	putative active site [active]
504472010715	catalytic site [active]
504472010716	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472010717	ATP binding site [chemical binding]; other site
504472010718	putative Mg++ binding site [ion binding]; other site
504472010719	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
504472010720	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
504472010721	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472010722	catalytic residue [active]
504472010723	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
504472010724	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
504472010725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472010726	Walker A motif; other site
504472010727	ATP binding site [chemical binding]; other site
504472010728	Walker B motif; other site
504472010729	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
504472010730	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
504472010731	DNA-binding site [nucleotide binding]; DNA binding site
504472010732	RNA-binding motif; other site
504472010733	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472010734	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
504472010735	dimerization interface [polypeptide binding]; other site
504472010736	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472010737	dimer interface [polypeptide binding]; other site
504472010738	phosphorylation site [posttranslational modification]
504472010739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472010740	ATP binding site [chemical binding]; other site
504472010741	Mg2+ binding site [ion binding]; other site
504472010742	G-X-G motif; other site
504472010743	Outer membrane efflux protein; Region: OEP; pfam02321
504472010744	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472010745	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
504472010746	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472010747	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472010748	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
504472010749	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
504472010750	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472010751	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472010752	primosomal protein N' Region: priA; TIGR00595
504472010753	ATP binding site [chemical binding]; other site
504472010754	putative Mg++ binding site [ion binding]; other site
504472010755	helicase superfamily c-terminal domain; Region: HELICc; smart00490
504472010756	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
504472010757	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
504472010758	domain interfaces; other site
504472010759	active site
504472010760	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
504472010761	G1 box; other site
504472010762	GTP/Mg2+ binding site [chemical binding]; other site
504472010763	Switch I region; other site
504472010764	G2 box; other site
504472010765	G3 box; other site
504472010766	Switch II region; other site
504472010767	G4 box; other site
504472010768	G5 box; other site
504472010769	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472010770	catalytic residues [active]
504472010771	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
504472010772	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
504472010773	Mg++ binding site [ion binding]; other site
504472010774	putative catalytic motif [active]
504472010775	putative substrate binding site [chemical binding]; other site
504472010776	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472010777	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
504472010778	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
504472010779	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472010780	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
504472010781	putative NAD(P) binding site [chemical binding]; other site
504472010782	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472010783	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472010784	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472010785	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
504472010786	active site
504472010787	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
504472010788	homodimer interface [polypeptide binding]; other site
504472010789	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472010790	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472010791	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472010792	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472010793	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472010794	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
504472010795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
504472010796	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
504472010797	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
504472010798	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
504472010799	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
504472010800	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
504472010801	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
504472010802	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
504472010803	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
504472010804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472010805	active site
504472010806	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
504472010807	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
504472010808	adenylosuccinate lyase; Provisional; Region: PRK09285
504472010809	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
504472010810	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
504472010811	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
504472010812	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472010813	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
504472010814	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472010815	ligand binding site [chemical binding]; other site
504472010816	metal binding site [ion binding]; metal-binding site
504472010817	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
504472010818	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472010819	FAD binding domain; Region: FAD_binding_4; pfam01565
504472010820	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472010821	SLBB domain; Region: SLBB; pfam10531
504472010822	Chain length determinant protein; Region: Wzz; cl15801
504472010823	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
504472010824	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
504472010825	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
504472010826	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472010827	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472010828	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472010829	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
504472010830	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
504472010831	trimer interface [polypeptide binding]; other site
504472010832	active site
504472010833	substrate binding site [chemical binding]; other site
504472010834	CoA binding site [chemical binding]; other site
504472010835	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472010836	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
504472010837	Probable Catalytic site; other site
504472010838	metal-binding site
504472010839	Uncharacterized conserved protein [Function unknown]; Region: COG3743
504472010840	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
504472010841	ligand binding site [chemical binding]; other site
504472010842	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472010843	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472010844	ligand binding site [chemical binding]; other site
504472010845	Protein of unknown function (DUF877); Region: DUF877; pfam05943
504472010846	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
504472010847	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472010848	Walker A motif; other site
504472010849	ATP binding site [chemical binding]; other site
504472010850	Walker B motif; other site
504472010851	arginine finger; other site
504472010852	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472010853	Walker A motif; other site
504472010854	ATP binding site [chemical binding]; other site
504472010855	Walker B motif; other site
504472010856	arginine finger; other site
504472010857	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
504472010858	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
504472010859	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
504472010860	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
504472010861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
504472010862	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
504472010863	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
504472010864	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
504472010865	TPR motif; other site
504472010866	binding surface
504472010867	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
504472010868	RHS Repeat; Region: RHS_repeat; pfam05593
504472010869	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
504472010870	Uncharacterized conserved protein [Function unknown]; Region: COG4104
504472010871	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472010872	Protein of unknown function (DUF877); Region: DUF877; pfam05943
504472010873	Protein of unknown function (DUF796); Region: DUF796; cl01226
504472010874	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472010875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472010876	Walker A motif; other site
504472010877	ATP binding site [chemical binding]; other site
504472010878	Walker B motif; other site
504472010879	arginine finger; other site
504472010880	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
504472010881	HSP70 interaction site [polypeptide binding]; other site
504472010882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
504472010883	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
504472010884	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
504472010885	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
504472010886	active site
504472010887	ATP binding site [chemical binding]; other site
504472010888	KWG Leptospira; Region: KWG; pfam07656
504472010889	AAA ATPase domain; Region: AAA_15; pfam13175
504472010890	AAA domain; Region: AAA_21; pfam13304
504472010891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472010892	Walker B; other site
504472010893	D-loop; other site
504472010894	H-loop/switch region; other site
504472010895	LytTr DNA-binding domain; Region: LytTR; pfam04397
504472010896	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
504472010897	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
504472010898	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
504472010899	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
504472010900	MOSC domain; Region: MOSC; pfam03473
504472010901	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472010902	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472010903	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472010904	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472010905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472010906	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
504472010907	putative substrate translocation pore; other site
504472010908	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472010909	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472010910	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
504472010911	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472010912	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472010913	active site
504472010914	catalytic tetrad [active]
504472010915	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472010916	Putative esterase; Region: Esterase; pfam00756
504472010917	S-formylglutathione hydrolase; Region: PLN02442
504472010918	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
504472010919	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
504472010920	substrate binding pocket [chemical binding]; other site
504472010921	catalytic triad [active]
504472010922	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
504472010923	Citrate transporter; Region: CitMHS; pfam03600
504472010924	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
504472010925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472010926	Response regulator receiver domain; Region: Response_reg; pfam00072
504472010927	active site
504472010928	phosphorylation site [posttranslational modification]
504472010929	intermolecular recognition site; other site
504472010930	dimerization interface [polypeptide binding]; other site
504472010931	Response regulator receiver domain; Region: Response_reg; pfam00072
504472010932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472010933	active site
504472010934	phosphorylation site [posttranslational modification]
504472010935	intermolecular recognition site; other site
504472010936	dimerization interface [polypeptide binding]; other site
504472010937	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
504472010938	cyanophycin synthetase; Provisional; Region: PRK14016
504472010939	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
504472010940	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472010941	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472010942	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
504472010943	proposed catalytic triad [active]
504472010944	active site nucleophile [active]
504472010945	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
504472010946	proposed catalytic triad [active]
504472010947	active site nucleophile [active]
504472010948	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
504472010949	catalytic nucleophile [active]
504472010950	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
504472010951	dimerization interface [polypeptide binding]; other site
504472010952	metal binding site [ion binding]; metal-binding site
504472010953	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
504472010954	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
504472010955	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472010956	active site
504472010957	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
504472010958	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
504472010959	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
504472010960	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472010961	UDP-galactopyranose mutase; Region: GLF; pfam03275
504472010962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
504472010963	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472010964	active site
504472010965	phosphorylation site [posttranslational modification]
504472010966	intermolecular recognition site; other site
504472010967	dimerization interface [polypeptide binding]; other site
504472010968	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472010969	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472010970	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472010971	DNA binding residues [nucleotide binding]
504472010972	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
504472010973	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
504472010974	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
504472010975	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
504472010976	active site
504472010977	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
504472010978	dimer interface [polypeptide binding]; other site
504472010979	non-prolyl cis peptide bond; other site
504472010980	insertion regions; other site
504472010981	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472010982	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472010983	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472010984	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472010985	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472010986	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472010987	HNH endonuclease; Region: HNH_2; pfam13391
504472010988	amino acid transporter; Region: 2A0306; TIGR00909
504472010989	amino acid transporter; Region: 2A0306; TIGR00909
504472010990	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
504472010991	Predicted transcriptional regulator [Transcription]; Region: COG1959
504472010992	Transcriptional regulator; Region: Rrf2; pfam02082
504472010993	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
504472010994	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
504472010995	putative metal binding site [ion binding]; other site
504472010996	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
504472010997	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
504472010998	dimer interface [polypeptide binding]; other site
504472010999	anticodon binding site; other site
504472011000	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
504472011001	homodimer interface [polypeptide binding]; other site
504472011002	motif 1; other site
504472011003	active site
504472011004	motif 2; other site
504472011005	GAD domain; Region: GAD; pfam02938
504472011006	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
504472011007	active site
504472011008	motif 3; other site
504472011009	Sulfatase; Region: Sulfatase; cl17466
504472011010	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472011011	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472011012	conserved repeat domain; Region: B_ant_repeat; TIGR01451
504472011013	CARDB; Region: CARDB; pfam07705
504472011014	Immunoglobulin domain; Region: Ig; cl11960
504472011015	Domain of unknown function DUF11; Region: DUF11; pfam01345
504472011016	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
504472011017	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
504472011018	active site
504472011019	tetramer interface; other site
504472011020	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
504472011021	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
504472011022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472011023	non-specific DNA binding site [nucleotide binding]; other site
504472011024	salt bridge; other site
504472011025	sequence-specific DNA binding site [nucleotide binding]; other site
504472011026	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
504472011027	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
504472011028	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472011029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472011030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472011031	DNA binding residues [nucleotide binding]
504472011032	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472011033	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
504472011034	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
504472011035	Beta-lactamase; Region: Beta-lactamase; cl17358
504472011036	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472011037	DinB family; Region: DinB; cl17821
504472011038	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472011039	PAS domain; Region: PAS_9; pfam13426
504472011040	putative active site [active]
504472011041	heme pocket [chemical binding]; other site
504472011042	PAS fold; Region: PAS_3; pfam08447
504472011043	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
504472011044	PAS domain S-box; Region: sensory_box; TIGR00229
504472011045	PAS domain S-box; Region: sensory_box; TIGR00229
504472011046	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472011047	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
504472011048	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472011049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472011050	putative active site [active]
504472011051	heme pocket [chemical binding]; other site
504472011052	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472011053	dimer interface [polypeptide binding]; other site
504472011054	phosphorylation site [posttranslational modification]
504472011055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472011056	ATP binding site [chemical binding]; other site
504472011057	Mg2+ binding site [ion binding]; other site
504472011058	G-X-G motif; other site
504472011059	Response regulator receiver domain; Region: Response_reg; pfam00072
504472011060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472011061	active site
504472011062	phosphorylation site [posttranslational modification]
504472011063	intermolecular recognition site; other site
504472011064	dimerization interface [polypeptide binding]; other site
504472011065	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
504472011066	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472011067	NAD binding site [chemical binding]; other site
504472011068	catalytic Zn binding site [ion binding]; other site
504472011069	structural Zn binding site [ion binding]; other site
504472011070	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
504472011071	classical (c) SDRs; Region: SDR_c; cd05233
504472011072	NAD(P) binding site [chemical binding]; other site
504472011073	active site
504472011074	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
504472011075	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
504472011076	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
504472011077	minor groove reading motif; other site
504472011078	helix-hairpin-helix signature motif; other site
504472011079	substrate binding pocket [chemical binding]; other site
504472011080	active site
504472011081	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472011082	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472011083	ligand binding site [chemical binding]; other site
504472011084	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011085	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011086	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011087	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472011088	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472011089	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472011090	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
504472011091	proposed catalytic triad [active]
504472011092	active site nucleophile [active]
504472011093	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472011094	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472011095	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011096	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011097	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011098	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011099	Predicted membrane protein [Function unknown]; Region: COG2323
504472011100	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
504472011101	Predicted membrane protein [Function unknown]; Region: COG4325
504472011102	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
504472011103	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
504472011104	active site
504472011105	FOG: PKD repeat [General function prediction only]; Region: COG3291
504472011106	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472011107	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472011108	Calx-beta domain; Region: Calx-beta; cl02522
504472011109	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472011110	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011111	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011112	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472011113	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011114	SusD family; Region: SusD; pfam07980
504472011115	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011116	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011117	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011118	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011119	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472011120	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
504472011121	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472011122	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
504472011123	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
504472011124	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434
504472011125	active site
504472011126	zinc binding site [ion binding]; other site
504472011127	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
504472011128	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
504472011129	putative active site [active]
504472011130	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472011131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472011132	Walker A/P-loop; other site
504472011133	ATP binding site [chemical binding]; other site
504472011134	Q-loop/lid; other site
504472011135	ABC transporter signature motif; other site
504472011136	Walker B; other site
504472011137	D-loop; other site
504472011138	H-loop/switch region; other site
504472011139	SpaB C-terminal domain; Region: SpaB_C; pfam14028
504472011140	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
504472011141	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
504472011142	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
504472011143	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472011144	transposase/IS protein; Provisional; Region: PRK09183
504472011145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472011146	Walker A motif; other site
504472011147	ATP binding site [chemical binding]; other site
504472011148	Walker B motif; other site
504472011149	arginine finger; other site
504472011150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472011151	Integrase core domain; Region: rve; pfam00665
504472011152	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472011153	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011154	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011155	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011156	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011157	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
504472011158	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
504472011159	active site
504472011160	nucleophile elbow; other site
504472011161	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472011162	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472011163	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472011164	Uncharacterized conserved protein [Function unknown]; Region: COG2128
504472011165	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
504472011166	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
504472011167	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
504472011168	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
504472011169	Moco binding site; other site
504472011170	metal coordination site [ion binding]; other site
504472011171	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
504472011172	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
504472011173	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
504472011174	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
504472011175	D-xylulose kinase; Region: XylB; TIGR01312
504472011176	nucleotide binding site [chemical binding]; other site
504472011177	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
504472011178	Fasciclin domain; Region: Fasciclin; pfam02469
504472011179	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472011180	extended (e) SDRs; Region: SDR_e; cd08946
504472011181	NAD(P) binding site [chemical binding]; other site
504472011182	active site
504472011183	substrate binding site [chemical binding]; other site
504472011184	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
504472011185	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
504472011186	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
504472011187	substrate binding pocket [chemical binding]; other site
504472011188	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
504472011189	B12 binding site [chemical binding]; other site
504472011190	cobalt ligand [ion binding]; other site
504472011191	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
504472011192	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472011193	active site
504472011194	oxyanion hole [active]
504472011195	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
504472011196	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
504472011197	exopolyphosphatase; Region: exo_poly_only; TIGR03706
504472011198	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
504472011199	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
504472011200	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472011201	Sulfatase; Region: Sulfatase; cl17466
504472011202	Sulfatase; Region: Sulfatase; cl17466
504472011203	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
504472011204	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
504472011205	NAD(P) binding site [chemical binding]; other site
504472011206	homodimer interface [polypeptide binding]; other site
504472011207	substrate binding site [chemical binding]; other site
504472011208	active site
504472011209	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
504472011210	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
504472011211	inhibitor-cofactor binding pocket; inhibition site
504472011212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472011213	catalytic residue [active]
504472011214	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
504472011215	ligand binding site; other site
504472011216	tetramer interface; other site
504472011217	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
504472011218	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
504472011219	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472011220	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472011221	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472011222	pseudaminic acid synthase; Region: PseI; TIGR03586
504472011223	NeuB family; Region: NeuB; pfam03102
504472011224	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
504472011225	NeuB binding interface [polypeptide binding]; other site
504472011226	putative substrate binding site [chemical binding]; other site
504472011227	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472011228	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472011229	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
504472011230	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
504472011231	putative glycosyl transferase; Provisional; Region: PRK10125
504472011232	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
504472011233	metal-binding site
504472011234	6-phosphofructokinase; Provisional; Region: PRK03202
504472011235	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
504472011236	active site
504472011237	ADP/pyrophosphate binding site [chemical binding]; other site
504472011238	dimerization interface [polypeptide binding]; other site
504472011239	allosteric effector site; other site
504472011240	fructose-1,6-bisphosphate binding site; other site
504472011241	Uncharacterized conserved protein [Function unknown]; Region: COG1434
504472011242	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
504472011243	putative active site [active]
504472011244	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
504472011245	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472011246	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472011247	catalytic residues [active]
504472011248	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
504472011249	Protein of unknown function DUF58; Region: DUF58; pfam01882
504472011250	von Willebrand factor type A domain; Region: VWA_2; pfam13519
504472011251	metal ion-dependent adhesion site (MIDAS); other site
504472011252	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
504472011253	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
504472011254	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
504472011255	GTP-binding protein YchF; Reviewed; Region: PRK09601
504472011256	YchF GTPase; Region: YchF; cd01900
504472011257	G1 box; other site
504472011258	GTP/Mg2+ binding site [chemical binding]; other site
504472011259	Switch I region; other site
504472011260	G2 box; other site
504472011261	Switch II region; other site
504472011262	G3 box; other site
504472011263	G4 box; other site
504472011264	G5 box; other site
504472011265	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
504472011266	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
504472011267	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
504472011268	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472011269	FeS/SAM binding site; other site
504472011270	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
504472011271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472011272	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472011273	ABC transporter; Region: ABC_tran_2; pfam12848
504472011274	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472011275	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011276	Interdomain contacts; other site
504472011277	Cytokine receptor motif; other site
504472011278	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
504472011279	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011280	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
504472011281	NAD binding site [chemical binding]; other site
504472011282	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011283	Interdomain contacts; other site
504472011284	Cytokine receptor motif; other site
504472011285	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011286	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011287	Interdomain contacts; other site
504472011288	Cytokine receptor motif; other site
504472011289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472011290	Integrase core domain; Region: rve; pfam00665
504472011291	transposase/IS protein; Provisional; Region: PRK09183
504472011292	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472011293	Walker A motif; other site
504472011294	ATP binding site [chemical binding]; other site
504472011295	Walker B motif; other site
504472011296	arginine finger; other site
504472011297	DNA recombination protein RecA; Reviewed; Region: recA; PRK09519
504472011298	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
504472011299	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011300	Interdomain contacts; other site
504472011301	Cytokine receptor motif; other site
504472011302	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
504472011303	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
504472011304	Transcriptional regulator [Transcription]; Region: LysR; COG0583
504472011305	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472011306	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
504472011307	dimerization interface [polypeptide binding]; other site
504472011308	isocitrate dehydrogenase; Validated; Region: PRK09222
504472011309	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
504472011310	Homeodomain-like domain; Region: HTH_23; pfam13384
504472011311	Winged helix-turn helix; Region: HTH_29; pfam13551
504472011312	Homeodomain-like domain; Region: HTH_32; pfam13565
504472011313	Winged helix-turn helix; Region: HTH_33; pfam13592
504472011314	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472011315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472011316	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
504472011317	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
504472011318	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472011319	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472011320	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472011321	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011322	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011323	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011324	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472011325	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011326	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472011327	active site
504472011328	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472011329	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472011330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472011331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472011332	dimer interface [polypeptide binding]; other site
504472011333	phosphorylation site [posttranslational modification]
504472011334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472011335	ATP binding site [chemical binding]; other site
504472011336	Mg2+ binding site [ion binding]; other site
504472011337	G-X-G motif; other site
504472011338	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472011339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472011340	active site
504472011341	phosphorylation site [posttranslational modification]
504472011342	intermolecular recognition site; other site
504472011343	dimerization interface [polypeptide binding]; other site
504472011344	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472011345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472011346	PAS fold; Region: PAS_4; pfam08448
504472011347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472011348	putative active site [active]
504472011349	heme pocket [chemical binding]; other site
504472011350	PAS fold; Region: PAS_4; pfam08448
504472011351	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
504472011352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472011353	putative active site [active]
504472011354	heme pocket [chemical binding]; other site
504472011355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472011356	dimer interface [polypeptide binding]; other site
504472011357	phosphorylation site [posttranslational modification]
504472011358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472011359	ATP binding site [chemical binding]; other site
504472011360	Mg2+ binding site [ion binding]; other site
504472011361	G-X-G motif; other site
504472011362	Major royal jelly protein; Region: MRJP; pfam03022
504472011363	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
504472011364	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472011365	Zn binding site [ion binding]; other site
504472011366	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
504472011367	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472011368	Zn binding site [ion binding]; other site
504472011369	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
504472011370	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
504472011371	dimerization interface [polypeptide binding]; other site
504472011372	DPS ferroxidase diiron center [ion binding]; other site
504472011373	ion pore; other site
504472011374	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
504472011375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472011376	TPR motif; other site
504472011377	binding surface
504472011378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
504472011379	Histidine kinase; Region: HisKA_2; pfam07568
504472011380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472011381	ATP binding site [chemical binding]; other site
504472011382	Mg2+ binding site [ion binding]; other site
504472011383	G-X-G motif; other site
504472011384	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472011385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472011386	active site
504472011387	phosphorylation site [posttranslational modification]
504472011388	intermolecular recognition site; other site
504472011389	dimerization interface [polypeptide binding]; other site
504472011390	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472011391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472011392	Walker A motif; other site
504472011393	ATP binding site [chemical binding]; other site
504472011394	Walker B motif; other site
504472011395	arginine finger; other site
504472011396	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
504472011397	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472011398	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472011399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472011400	YceI-like domain; Region: YceI; pfam04264
504472011401	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472011402	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472011403	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472011404	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
504472011405	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
504472011406	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472011407	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472011408	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
504472011409	active site
504472011410	catalytic triad [active]
504472011411	oxyanion hole [active]
504472011412	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
504472011413	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
504472011414	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472011415	active site
504472011416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472011417	Coenzyme A binding pocket [chemical binding]; other site
504472011418	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
504472011419	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
504472011420	homotetramer interface [polypeptide binding]; other site
504472011421	ligand binding site [chemical binding]; other site
504472011422	catalytic site [active]
504472011423	NAD binding site [chemical binding]; other site
504472011424	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
504472011425	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
504472011426	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472011427	active site
504472011428	metal binding site [ion binding]; metal-binding site
504472011429	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
504472011430	hydroperoxidase II; Provisional; Region: katE; PRK11249
504472011431	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
504472011432	tetramer interface [polypeptide binding]; other site
504472011433	heme binding pocket [chemical binding]; other site
504472011434	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
504472011435	domain interactions; other site
504472011436	Right handed beta helix region; Region: Beta_helix; pfam13229
504472011437	Right handed beta helix region; Region: Beta_helix; pfam13229
504472011438	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
504472011439	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
504472011440	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472011441	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
504472011442	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472011443	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
504472011444	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
504472011445	Chain length determinant protein; Region: Wzz; cl15801
504472011446	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
504472011447	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
504472011448	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472011449	Bacterial sugar transferase; Region: Bac_transf; pfam02397
504472011450	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
504472011451	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
504472011452	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472011453	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472011454	NAD(P) binding site [chemical binding]; other site
504472011455	active site
504472011456	Cupin domain; Region: Cupin_2; pfam07883
504472011457	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472011458	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
504472011459	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
504472011460	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
504472011461	Probable Catalytic site; other site
504472011462	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472011463	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472011464	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472011465	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
504472011466	Probable Catalytic site; other site
504472011467	metal-binding site
504472011468	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472011469	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472011470	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472011471	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472011472	active site
504472011473	catalytic tetrad [active]
504472011474	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472011475	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472011476	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472011477	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472011478	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472011479	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472011480	IPT/TIG domain; Region: TIG; pfam01833
504472011481	LytTr DNA-binding domain; Region: LytTR; smart00850
504472011482	Response regulator receiver domain; Region: Response_reg; pfam00072
504472011483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472011484	active site
504472011485	phosphorylation site [posttranslational modification]
504472011486	intermolecular recognition site; other site
504472011487	dimerization interface [polypeptide binding]; other site
504472011488	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472011489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
504472011490	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
504472011491	DNA-binding site [nucleotide binding]; DNA binding site
504472011492	UTRA domain; Region: UTRA; pfam07702
504472011493	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472011494	active site
504472011495	catalytic triad [active]
504472011496	oxyanion hole [active]
504472011497	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
504472011498	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472011499	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472011500	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472011501	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011502	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011503	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011504	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472011505	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011506	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
504472011507	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
504472011508	hexamer (dimer of trimers) interface [polypeptide binding]; other site
504472011509	trimer interface [polypeptide binding]; other site
504472011510	substrate binding site [chemical binding]; other site
504472011511	Mn binding site [ion binding]; other site
504472011512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472011513	D-galactonate transporter; Region: 2A0114; TIGR00893
504472011514	putative substrate translocation pore; other site
504472011515	xylose isomerase; Provisional; Region: PRK05474
504472011516	xylose isomerase; Region: xylose_isom_A; TIGR02630
504472011517	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
504472011518	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
504472011519	enoyl-CoA hydratase; Provisional; Region: PRK05995
504472011520	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472011521	substrate binding site [chemical binding]; other site
504472011522	oxyanion hole (OAH) forming residues; other site
504472011523	trimer interface [polypeptide binding]; other site
504472011524	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472011525	Radical SAM superfamily; Region: Radical_SAM; pfam04055
504472011526	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472011527	FeS/SAM binding site; other site
504472011528	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
504472011529	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
504472011530	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472011531	C-terminal peptidase (prc); Region: prc; TIGR00225
504472011532	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
504472011533	protein binding site [polypeptide binding]; other site
504472011534	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
504472011535	Catalytic dyad [active]
504472011536	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
504472011537	TPR repeat; Region: TPR_11; pfam13414
504472011538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472011539	binding surface
504472011540	TPR motif; other site
504472011541	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472011542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472011543	binding surface
504472011544	TPR motif; other site
504472011545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472011546	binding surface
504472011547	TPR motif; other site
504472011548	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
504472011549	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
504472011550	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472011551	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
504472011552	oligomerization interface [polypeptide binding]; other site
504472011553	active site
504472011554	metal binding site [ion binding]; metal-binding site
504472011555	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
504472011556	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
504472011557	active site
504472011558	aspartate aminotransferase; Provisional; Region: PRK05764
504472011559	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472011560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472011561	homodimer interface [polypeptide binding]; other site
504472011562	catalytic residue [active]
504472011563	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
504472011564	catalytic center binding site [active]
504472011565	ATP binding site [chemical binding]; other site
504472011566	Uncharacterized conserved protein [Function unknown]; Region: COG1262
504472011567	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
504472011568	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
504472011569	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
504472011570	Walker A/P-loop; other site
504472011571	ATP binding site [chemical binding]; other site
504472011572	Q-loop/lid; other site
504472011573	ABC transporter signature motif; other site
504472011574	Walker B; other site
504472011575	D-loop; other site
504472011576	H-loop/switch region; other site
504472011577	ABC transporter; Region: ABC_tran_2; pfam12848
504472011578	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472011579	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
504472011580	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
504472011581	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
504472011582	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
504472011583	NAD(P) binding site [chemical binding]; other site
504472011584	catalytic residues [active]
504472011585	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472011586	MarR family; Region: MarR_2; pfam12802
504472011587	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
504472011588	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472011589	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472011590	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
504472011591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472011592	putative substrate translocation pore; other site
504472011593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472011594	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
504472011595	acyl carrier protein; Provisional; Region: acpP; PRK00982
504472011596	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
504472011597	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
504472011598	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
504472011599	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
504472011600	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472011601	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472011602	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
504472011603	Gram-negative bacterial tonB protein; Region: TonB; cl10048
504472011604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
504472011605	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472011606	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
504472011607	Class I aldolases; Region: Aldolase_Class_I; cl17187
504472011608	catalytic residue [active]
504472011609	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
504472011610	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
504472011611	RNA binding surface [nucleotide binding]; other site
504472011612	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
504472011613	active site
504472011614	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
504472011615	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
504472011616	acyl-activating enzyme (AAE) consensus motif; other site
504472011617	putative AMP binding site [chemical binding]; other site
504472011618	putative active site [active]
504472011619	putative CoA binding site [chemical binding]; other site
504472011620	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472011621	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472011622	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472011623	DNA binding residues [nucleotide binding]
504472011624	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
504472011625	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
504472011626	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
504472011627	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
504472011628	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472011629	substrate binding site [chemical binding]; other site
504472011630	oxyanion hole (OAH) forming residues; other site
504472011631	trimer interface [polypeptide binding]; other site
504472011632	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472011633	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
504472011634	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472011635	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472011636	catalytic residues [active]
504472011637	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
504472011638	MraW methylase family; Region: Methyltransf_5; cl17771
504472011639	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472011640	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472011641	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472011642	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472011643	Fasciclin domain; Region: Fasciclin; pfam02469
504472011644	Fasciclin domain; Region: Fasciclin; pfam02469
504472011645	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
504472011646	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
504472011647	catalytic residue [active]
504472011648	putative FPP diphosphate  binding site; other site
504472011649	putative FPP binding hydrophobic cleft; other site
504472011650	dimer interface [polypeptide binding]; other site
504472011651	putative IPP diphosphate binding site; other site
504472011652	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
504472011653	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
504472011654	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
504472011655	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
504472011656	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472011657	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
504472011658	periplasmic chaperone; Provisional; Region: PRK10780
504472011659	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
504472011660	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472011661	Protein export membrane protein; Region: SecD_SecF; cl14618
504472011662	Protein export membrane protein; Region: SecD_SecF; cl14618
504472011663	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472011664	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472011665	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472011666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472011667	DNA binding residues [nucleotide binding]
504472011668	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472011669	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472011670	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472011671	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472011672	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
504472011673	active site
504472011674	catalytic residues [active]
504472011675	30S ribosomal protein S7; Validated; Region: PRK05302
504472011676	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
504472011677	S17 interaction site [polypeptide binding]; other site
504472011678	S8 interaction site; other site
504472011679	16S rRNA interaction site [nucleotide binding]; other site
504472011680	streptomycin interaction site [chemical binding]; other site
504472011681	23S rRNA interaction site [nucleotide binding]; other site
504472011682	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
504472011683	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
504472011684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
504472011685	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472011686	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472011687	catalytic residues [active]
504472011688	pyruvate carboxylase; Reviewed; Region: PRK12999
504472011689	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
504472011690	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472011691	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
504472011692	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
504472011693	active site
504472011694	catalytic residues [active]
504472011695	metal binding site [ion binding]; metal-binding site
504472011696	homodimer binding site [polypeptide binding]; other site
504472011697	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
504472011698	carboxyltransferase (CT) interaction site; other site
504472011699	biotinylation site [posttranslational modification]; other site
504472011700	YcfA-like protein; Region: YcfA; pfam07927
504472011701	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
504472011702	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
504472011703	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
504472011704	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
504472011705	pantoate--beta-alanine ligase; Region: panC; TIGR00018
504472011706	Pantoate-beta-alanine ligase; Region: PanC; cd00560
504472011707	active site
504472011708	ATP-binding site [chemical binding]; other site
504472011709	pantoate-binding site; other site
504472011710	HXXH motif; other site
504472011711	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
504472011712	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
504472011713	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
504472011714	glutaminase active site [active]
504472011715	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
504472011716	dimer interface [polypeptide binding]; other site
504472011717	active site
504472011718	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
504472011719	dimer interface [polypeptide binding]; other site
504472011720	active site
504472011721	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472011722	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472011723	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
504472011724	Penicillin amidase; Region: Penicil_amidase; pfam01804
504472011725	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472011726	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472011727	active site
504472011728	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472011729	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
504472011730	Amidase; Region: Amidase; pfam01425
504472011731	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011732	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472011733	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472011734	N-terminal plug; other site
504472011735	ligand-binding site [chemical binding]; other site
504472011736	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011737	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472011738	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011739	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011740	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
504472011741	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
504472011742	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
504472011743	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
504472011744	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
504472011745	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
504472011746	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
504472011747	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
504472011748	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
504472011749	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
504472011750	DNA binding site [nucleotide binding]
504472011751	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
504472011752	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
504472011753	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
504472011754	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
504472011755	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
504472011756	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
504472011757	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
504472011758	RPB3 interaction site [polypeptide binding]; other site
504472011759	RPB1 interaction site [polypeptide binding]; other site
504472011760	RPB11 interaction site [polypeptide binding]; other site
504472011761	RPB10 interaction site [polypeptide binding]; other site
504472011762	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
504472011763	core dimer interface [polypeptide binding]; other site
504472011764	peripheral dimer interface [polypeptide binding]; other site
504472011765	L10 interface [polypeptide binding]; other site
504472011766	L11 interface [polypeptide binding]; other site
504472011767	putative EF-Tu interaction site [polypeptide binding]; other site
504472011768	putative EF-G interaction site [polypeptide binding]; other site
504472011769	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
504472011770	23S rRNA interface [nucleotide binding]; other site
504472011771	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
504472011772	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
504472011773	mRNA/rRNA interface [nucleotide binding]; other site
504472011774	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
504472011775	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
504472011776	23S rRNA interface [nucleotide binding]; other site
504472011777	L7/L12 interface [polypeptide binding]; other site
504472011778	putative thiostrepton binding site; other site
504472011779	L25 interface [polypeptide binding]; other site
504472011780	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
504472011781	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
504472011782	putative homodimer interface [polypeptide binding]; other site
504472011783	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
504472011784	heterodimer interface [polypeptide binding]; other site
504472011785	homodimer interface [polypeptide binding]; other site
504472011786	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
504472011787	elongation factor Tu; Reviewed; Region: PRK12735
504472011788	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
504472011789	G1 box; other site
504472011790	GEF interaction site [polypeptide binding]; other site
504472011791	GTP/Mg2+ binding site [chemical binding]; other site
504472011792	Switch I region; other site
504472011793	G2 box; other site
504472011794	G3 box; other site
504472011795	Switch II region; other site
504472011796	G4 box; other site
504472011797	G5 box; other site
504472011798	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
504472011799	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
504472011800	Antibiotic Binding Site [chemical binding]; other site
504472011801	lipoprotein LpqB; Provisional; Region: PRK13616
504472011802	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
504472011803	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
504472011804	active site
504472011805	Zn binding site [ion binding]; other site
504472011806	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
504472011807	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
504472011808	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
504472011809	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
504472011810	active site
504472011811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472011812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472011813	WHG domain; Region: WHG; pfam13305
504472011814	Outer membrane efflux protein; Region: OEP; pfam02321
504472011815	Outer membrane efflux protein; Region: OEP; pfam02321
504472011816	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472011817	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472011818	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472011819	malate dehydrogenase; Reviewed; Region: PRK06223
504472011820	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
504472011821	dimer interface [polypeptide binding]; other site
504472011822	NAD(P) binding site [chemical binding]; other site
504472011823	tetramer (dimer of dimers) interface [polypeptide binding]; other site
504472011824	substrate binding site [chemical binding]; other site
504472011825	Uncharacterized conserved protein [Function unknown]; Region: COG3339
504472011826	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
504472011827	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
504472011828	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
504472011829	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
504472011830	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
504472011831	N-acetyl-D-glucosamine binding site [chemical binding]; other site
504472011832	catalytic residue [active]
504472011833	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472011834	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472011835	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
504472011836	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
504472011837	RuvA N terminal domain; Region: RuvA_N; pfam01330
504472011838	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
504472011839	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
504472011840	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472011841	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472011842	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472011843	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011844	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011845	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011846	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472011847	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472011848	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472011849	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472011850	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472011851	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472011852	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
504472011853	putative NAD(P) binding site [chemical binding]; other site
504472011854	catalytic Zn binding site [ion binding]; other site
504472011855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472011856	Walker A motif; other site
504472011857	ATP binding site [chemical binding]; other site
504472011858	Walker B motif; other site
504472011859	arginine finger; other site
504472011860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
504472011861	Protein of unknown function (DUF433); Region: DUF433; pfam04255
504472011862	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
504472011863	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
504472011864	putative catalytic residues [active]
504472011865	nucleotide binding site [chemical binding]; other site
504472011866	aspartate binding site [chemical binding]; other site
504472011867	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
504472011868	dimer interface [polypeptide binding]; other site
504472011869	putative threonine allosteric regulatory site; other site
504472011870	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
504472011871	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
504472011872	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
504472011873	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
504472011874	dinuclear metal binding motif [ion binding]; other site
504472011875	Ferritin-like domain; Region: Ferritin_2; pfam13668
504472011876	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
504472011877	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
504472011878	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
504472011879	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
504472011880	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
504472011881	NodB motif; other site
504472011882	active site
504472011883	catalytic site [active]
504472011884	metal binding site [ion binding]; metal-binding site
504472011885	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
504472011886	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
504472011887	THF binding site; other site
504472011888	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
504472011889	substrate binding site [chemical binding]; other site
504472011890	THF binding site; other site
504472011891	zinc-binding site [ion binding]; other site
504472011892	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
504472011893	multifunctional aminopeptidase A; Provisional; Region: PRK00913
504472011894	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
504472011895	interface (dimer of trimers) [polypeptide binding]; other site
504472011896	Substrate-binding/catalytic site; other site
504472011897	Zn-binding sites [ion binding]; other site
504472011898	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
504472011899	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
504472011900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472011901	Response regulator receiver domain; Region: Response_reg; pfam00072
504472011902	active site
504472011903	phosphorylation site [posttranslational modification]
504472011904	intermolecular recognition site; other site
504472011905	dimerization interface [polypeptide binding]; other site
504472011906	Imelysin; Region: Peptidase_M75; pfam09375
504472011907	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
504472011908	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011909	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472011910	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
504472011911	BNR repeat-like domain; Region: BNR_2; pfam13088
504472011912	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011913	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472011914	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472011915	N-terminal plug; other site
504472011916	ligand-binding site [chemical binding]; other site
504472011917	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472011918	PAS domain; Region: PAS_9; pfam13426
504472011919	putative active site [active]
504472011920	heme pocket [chemical binding]; other site
504472011921	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
504472011922	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
504472011923	Leucine rich repeat; Region: LRR_8; pfam13855
504472011924	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472011925	active site
504472011926	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472011927	sugar binding site [chemical binding]; other site
504472011928	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472011929	Interdomain contacts; other site
504472011930	Cytokine receptor motif; other site
504472011931	Transposase IS200 like; Region: Y1_Tnp; pfam01797
504472011932	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472011933	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
504472011934	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472011935	FtsX-like permease family; Region: FtsX; pfam02687
504472011936	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472011937	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472011938	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472011939	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472011940	Walker A/P-loop; other site
504472011941	ATP binding site [chemical binding]; other site
504472011942	Q-loop/lid; other site
504472011943	ABC transporter signature motif; other site
504472011944	Walker B; other site
504472011945	D-loop; other site
504472011946	H-loop/switch region; other site
504472011947	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
504472011948	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472011949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472011950	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472011951	putative substrate translocation pore; other site
504472011952	Transposase IS200 like; Region: Y1_Tnp; cl00848
504472011953	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011954	MG2 domain; Region: A2M_N; pfam01835
504472011955	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472011956	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472011957	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
504472011958	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472011959	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472011960	active site
504472011961	catalytic tetrad [active]
504472011962	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472011963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472011964	active site
504472011965	phosphorylation site [posttranslational modification]
504472011966	intermolecular recognition site; other site
504472011967	dimerization interface [polypeptide binding]; other site
504472011968	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472011969	DNA binding site [nucleotide binding]
504472011970	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472011971	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
504472011972	dimer interface [polypeptide binding]; other site
504472011973	phosphorylation site [posttranslational modification]
504472011974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472011975	ATP binding site [chemical binding]; other site
504472011976	Mg2+ binding site [ion binding]; other site
504472011977	G-X-G motif; other site
504472011978	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011979	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
504472011980	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472011981	N-terminal plug; other site
504472011982	ligand-binding site [chemical binding]; other site
504472011983	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
504472011984	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
504472011985	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
504472011986	classical (c) SDRs; Region: SDR_c; cd05233
504472011987	NAD(P) binding site [chemical binding]; other site
504472011988	active site
504472011989	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472011990	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
504472011991	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472011992	N-terminal plug; other site
504472011993	ligand-binding site [chemical binding]; other site
504472011994	Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577
504472011995	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
504472011996	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472011997	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472011998	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
504472011999	active site
504472012000	WYL domain; Region: WYL; pfam13280
504472012001	WGR domain; Region: WGR; cl01581
504472012002	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283
504472012003	nad+ binding pocket [chemical binding]; other site
504472012004	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
504472012005	putative active site [active]
504472012006	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
504472012007	Fic family protein [Function unknown]; Region: COG3177
504472012008	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
504472012009	Fic/DOC family; Region: Fic; pfam02661
504472012010	IncA protein; Region: IncA; pfam04156
504472012011	P-loop containing region of AAA domain; Region: AAA_29; cl17516
504472012012	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
504472012013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472012014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472012015	ATP binding site [chemical binding]; other site
504472012016	Mg2+ binding site [ion binding]; other site
504472012017	G-X-G motif; other site
504472012018	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
504472012019	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
504472012020	homodimer interface [polypeptide binding]; other site
504472012021	putative substrate binding pocket [chemical binding]; other site
504472012022	diiron center [ion binding]; other site
504472012023	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
504472012024	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
504472012025	putative acyl-acceptor binding pocket; other site
504472012026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012027	Response regulator receiver domain; Region: Response_reg; pfam00072
504472012028	active site
504472012029	phosphorylation site [posttranslational modification]
504472012030	intermolecular recognition site; other site
504472012031	dimerization interface [polypeptide binding]; other site
504472012032	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
504472012033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472012034	Walker A motif; other site
504472012035	ATP binding site [chemical binding]; other site
504472012036	Walker B motif; other site
504472012037	arginine finger; other site
504472012038	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472012039	DNA-binding interface [nucleotide binding]; DNA binding site
504472012040	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
504472012041	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
504472012042	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472012043	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472012044	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472012045	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472012046	Walker A/P-loop; other site
504472012047	ATP binding site [chemical binding]; other site
504472012048	Q-loop/lid; other site
504472012049	ABC transporter signature motif; other site
504472012050	Walker B; other site
504472012051	D-loop; other site
504472012052	H-loop/switch region; other site
504472012053	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
504472012054	putative active site [active]
504472012055	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012056	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012057	FtsX-like permease family; Region: FtsX; pfam02687
504472012058	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012059	FtsX-like permease family; Region: FtsX; pfam02687
504472012060	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
504472012061	putative active site [active]
504472012062	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012063	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012064	FtsX-like permease family; Region: FtsX; pfam02687
504472012065	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012066	FtsX-like permease family; Region: FtsX; pfam02687
504472012067	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012068	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012069	FtsX-like permease family; Region: FtsX; pfam02687
504472012070	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012071	FtsX-like permease family; Region: FtsX; pfam02687
504472012072	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012073	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012074	FtsX-like permease family; Region: FtsX; pfam02687
504472012075	FtsX-like permease family; Region: FtsX; pfam02687
504472012076	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472012077	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012078	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012079	FtsX-like permease family; Region: FtsX; pfam02687
504472012080	FtsX-like permease family; Region: FtsX; pfam02687
504472012081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472012082	PAS domain; Region: PAS_9; pfam13426
504472012083	putative active site [active]
504472012084	heme pocket [chemical binding]; other site
504472012085	PAS domain; Region: PAS_9; pfam13426
504472012086	PAS domain; Region: PAS_9; pfam13426
504472012087	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
504472012088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472012089	phosphorylation site [posttranslational modification]
504472012090	dimer interface [polypeptide binding]; other site
504472012091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472012092	ATP binding site [chemical binding]; other site
504472012093	Mg2+ binding site [ion binding]; other site
504472012094	G-X-G motif; other site
504472012095	Domain of unknown function (DUF336); Region: DUF336; pfam03928
504472012096	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
504472012097	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
504472012098	NAD binding site [chemical binding]; other site
504472012099	catalytic Zn binding site [ion binding]; other site
504472012100	structural Zn binding site [ion binding]; other site
504472012101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012102	active site
504472012103	phosphorylation site [posttranslational modification]
504472012104	intermolecular recognition site; other site
504472012105	Response regulator receiver domain; Region: Response_reg; pfam00072
504472012106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012107	active site
504472012108	phosphorylation site [posttranslational modification]
504472012109	intermolecular recognition site; other site
504472012110	dimerization interface [polypeptide binding]; other site
504472012111	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472012112	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472012113	dimer interface [polypeptide binding]; other site
504472012114	phosphorylation site [posttranslational modification]
504472012115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472012116	ATP binding site [chemical binding]; other site
504472012117	Mg2+ binding site [ion binding]; other site
504472012118	G-X-G motif; other site
504472012119	Response regulator receiver domain; Region: Response_reg; pfam00072
504472012120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012121	active site
504472012122	phosphorylation site [posttranslational modification]
504472012123	intermolecular recognition site; other site
504472012124	dimerization interface [polypeptide binding]; other site
504472012125	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472012126	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472012127	Disaggregatase related; Region: Disaggr_assoc; pfam08480
504472012128	Right handed beta helix region; Region: Beta_helix; pfam13229
504472012129	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472012130	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012131	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012132	FtsX-like permease family; Region: FtsX; pfam02687
504472012133	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012134	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012135	FtsX-like permease family; Region: FtsX; pfam02687
504472012136	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
504472012137	putative active site [active]
504472012138	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012139	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012140	FtsX-like permease family; Region: FtsX; pfam02687
504472012141	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012142	FtsX-like permease family; Region: FtsX; pfam02687
504472012143	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
504472012144	putative ligand binding site [chemical binding]; other site
504472012145	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
504472012146	Predicted ATPase [General function prediction only]; Region: COG4637
504472012147	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
504472012148	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012149	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012150	FtsX-like permease family; Region: FtsX; pfam02687
504472012151	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012152	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012153	FtsX-like permease family; Region: FtsX; pfam02687
504472012154	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012155	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012156	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012157	FtsX-like permease family; Region: FtsX; pfam02687
504472012158	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012159	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012160	FtsX-like permease family; Region: FtsX; pfam02687
504472012161	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012162	FtsX-like permease family; Region: FtsX; pfam02687
504472012163	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012164	FtsX-like permease family; Region: FtsX; pfam02687
504472012165	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012166	FtsX-like permease family; Region: FtsX; pfam02687
504472012167	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012168	FtsX-like permease family; Region: FtsX; pfam02687
504472012169	FtsX-like permease family; Region: FtsX; pfam02687
504472012170	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012171	FtsX-like permease family; Region: FtsX; pfam02687
504472012172	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012173	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012174	FtsX-like permease family; Region: FtsX; pfam02687
504472012175	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472012176	Transcriptional regulator PadR-like family; Region: PadR; cl17335
504472012177	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012178	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012179	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012180	FtsX-like permease family; Region: FtsX; pfam02687
504472012181	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012182	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012183	FtsX-like permease family; Region: FtsX; pfam02687
504472012184	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012185	FtsX-like permease family; Region: FtsX; pfam02687
504472012186	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012187	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012188	FtsX-like permease family; Region: FtsX; pfam02687
504472012189	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012190	FtsX-like permease family; Region: FtsX; pfam02687
504472012191	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012192	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012193	FtsX-like permease family; Region: FtsX; pfam02687
504472012194	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012195	FtsX-like permease family; Region: FtsX; pfam02687
504472012196	intracellular protease, PfpI family; Region: PfpI; TIGR01382
504472012197	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
504472012198	conserved cys residue [active]
504472012199	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012200	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012201	FtsX-like permease family; Region: FtsX; pfam02687
504472012202	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012203	FtsX-like permease family; Region: FtsX; pfam02687
504472012204	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012205	FtsX-like permease family; Region: FtsX; pfam02687
504472012206	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012207	FtsX-like permease family; Region: FtsX; pfam02687
504472012208	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472012209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472012210	S-adenosylmethionine binding site [chemical binding]; other site
504472012211	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
504472012212	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012213	FtsX-like permease family; Region: FtsX; pfam02687
504472012214	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012215	FtsX-like permease family; Region: FtsX; pfam02687
504472012216	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472012217	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472012218	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472012219	DNA binding residues [nucleotide binding]
504472012220	Putative zinc-finger; Region: zf-HC2; pfam13490
504472012221	HEAT repeats; Region: HEAT_2; pfam13646
504472012222	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
504472012223	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472012224	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472012225	TPR repeat; Region: TPR_11; pfam13414
504472012226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472012227	TPR motif; other site
504472012228	binding surface
504472012229	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472012230	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472012231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472012232	TPR motif; other site
504472012233	binding surface
504472012234	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472012235	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472012236	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012237	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012238	FtsX-like permease family; Region: FtsX; pfam02687
504472012239	FtsX-like permease family; Region: FtsX; pfam02687
504472012240	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012241	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012242	FtsX-like permease family; Region: FtsX; pfam02687
504472012243	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012244	FtsX-like permease family; Region: FtsX; pfam02687
504472012245	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012246	FtsX-like permease family; Region: FtsX; pfam02687
504472012247	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012248	FtsX-like permease family; Region: FtsX; pfam02687
504472012249	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
504472012250	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472012251	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472012252	ligand binding site [chemical binding]; other site
504472012253	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
504472012254	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
504472012255	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
504472012256	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
504472012257	FAD binding domain; Region: FAD_binding_4; pfam01565
504472012258	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
504472012259	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
504472012260	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472012261	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
504472012262	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
504472012263	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472012264	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
504472012265	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472012266	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
504472012267	Fatty acid desaturase; Region: FA_desaturase; pfam00487
504472012268	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
504472012269	putative di-iron ligands [ion binding]; other site
504472012270	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
504472012271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472012272	S-adenosylmethionine binding site [chemical binding]; other site
504472012273	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
504472012274	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
504472012275	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
504472012276	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
504472012277	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
504472012278	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
504472012279	active site
504472012280	homodimer interface [polypeptide binding]; other site
504472012281	catalytic site [active]
504472012282	acceptor binding site [chemical binding]; other site
504472012283	PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380
504472012284	active site
504472012285	PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380
504472012286	active site
504472012287	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
504472012288	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
504472012289	active site
504472012290	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
504472012291	active site
504472012292	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472012293	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472012294	N-terminal plug; other site
504472012295	ligand-binding site [chemical binding]; other site
504472012296	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
504472012297	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472012298	FeS/SAM binding site; other site
504472012299	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
504472012300	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
504472012301	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472012302	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472012303	catalytic residues [active]
504472012304	NMT1/THI5 like; Region: NMT1; pfam09084
504472012305	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
504472012306	nudix motif; other site
504472012307	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
504472012308	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472012309	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
504472012310	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472012311	Cytochrome c; Region: Cytochrom_C; cl11414
504472012312	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472012313	ligand binding site [chemical binding]; other site
504472012314	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472012315	Trehalose utilisation; Region: ThuA; pfam06283
504472012316	Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802
504472012317	putative active site [active]
504472012318	YdjC motif; other site
504472012319	Mg binding site [ion binding]; other site
504472012320	homodimer interface [polypeptide binding]; other site
504472012321	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
504472012322	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
504472012323	putative active site [active]
504472012324	putative metal binding site [ion binding]; other site
504472012325	major curlin subunit; Provisional; Region: csgA; PRK10051
504472012326	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
504472012327	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
504472012328	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
504472012329	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
504472012330	active site
504472012331	catalytic triad [active]
504472012332	calcium binding site 1 [ion binding]; other site
504472012333	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
504472012334	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
504472012335	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472012336	catalytic residue [active]
504472012337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
504472012338	Transposase IS200 like; Region: Y1_Tnp; pfam01797
504472012339	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
504472012340	putative active site [active]
504472012341	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
504472012342	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
504472012343	active site
504472012344	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472012345	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472012346	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
504472012347	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472012348	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
504472012349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472012350	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
504472012351	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
504472012352	L-lactate permease; Region: Lactate_perm; cl00701
504472012353	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
504472012354	glycerate dehydrogenase; Provisional; Region: PRK06487
504472012355	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
504472012356	putative ligand binding site [chemical binding]; other site
504472012357	putative NAD binding site [chemical binding]; other site
504472012358	catalytic site [active]
504472012359	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472012360	active site residue [active]
504472012361	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472012362	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472012363	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472012364	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472012365	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
504472012366	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
504472012367	putative active site [active]
504472012368	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472012369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472012370	Walker A/P-loop; other site
504472012371	ATP binding site [chemical binding]; other site
504472012372	Q-loop/lid; other site
504472012373	ABC transporter signature motif; other site
504472012374	Walker B; other site
504472012375	D-loop; other site
504472012376	H-loop/switch region; other site
504472012377	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
504472012378	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
504472012379	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
504472012380	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
504472012381	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
504472012382	active site
504472012383	zinc binding site [ion binding]; other site
504472012384	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472012385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012386	active site
504472012387	phosphorylation site [posttranslational modification]
504472012388	intermolecular recognition site; other site
504472012389	dimerization interface [polypeptide binding]; other site
504472012390	LytTr DNA-binding domain; Region: LytTR; smart00850
504472012391	Histidine kinase; Region: His_kinase; pfam06580
504472012392	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
504472012393	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
504472012394	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
504472012395	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
504472012396	Alginate lyase; Region: Alginate_lyase; pfam05426
504472012397	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
504472012398	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
504472012399	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472012400	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472012401	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472012402	active site
504472012403	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472012404	catalytic tetrad [active]
504472012405	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
504472012406	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
504472012407	Catalytic site [active]
504472012408	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
504472012409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
504472012410	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
504472012411	Immunoglobulin domain; Region: Ig; cd00096
504472012412	NHL repeat; Region: NHL; pfam01436
504472012413	NHL repeat; Region: NHL; pfam01436
504472012414	NHL repeat; Region: NHL; pfam01436
504472012415	NHL repeat; Region: NHL; pfam01436
504472012416	NHL repeat; Region: NHL; pfam01436
504472012417	major curlin subunit; Provisional; Region: csgA; PRK10051
504472012418	major curlin subunit; Provisional; Region: csgA; PRK10051
504472012419	Curli assembly protein CsgE; Region: CsgE; cl08115
504472012420	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
504472012421	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
504472012422	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472012423	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
504472012424	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472012425	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472012426	Family description; Region: VCBS; pfam13517
504472012427	Family description; Region: VCBS; pfam13517
504472012428	Family description; Region: VCBS; pfam13517
504472012429	Family description; Region: VCBS; pfam13517
504472012430	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
504472012431	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472012432	Protein of unknown function (DUF3431); Region: DUF3431; pfam11913
504472012433	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472012434	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
504472012435	PA/protease or protease-like domain interface [polypeptide binding]; other site
504472012436	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472012437	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472012438	metal binding site [ion binding]; metal-binding site
504472012439	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
504472012440	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
504472012441	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
504472012442	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
504472012443	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
504472012444	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
504472012445	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472012446	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472012447	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
504472012448	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
504472012449	Mg++ binding site [ion binding]; other site
504472012450	putative catalytic motif [active]
504472012451	putative substrate binding site [chemical binding]; other site
504472012452	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
504472012453	23S rRNA interface [nucleotide binding]; other site
504472012454	L3 interface [polypeptide binding]; other site
504472012455	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
504472012456	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
504472012457	rRNA interaction site [nucleotide binding]; other site
504472012458	S8 interaction site; other site
504472012459	putative laminin-1 binding site; other site
504472012460	elongation factor Ts; Provisional; Region: tsf; PRK09377
504472012461	UBA/TS-N domain; Region: UBA; pfam00627
504472012462	Elongation factor TS; Region: EF_TS; pfam00889
504472012463	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472012464	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472012465	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472012466	DNA binding residues [nucleotide binding]
504472012467	Conserved TM helix; Region: TM_helix; pfam05552
504472012468	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
504472012469	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
504472012470	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
504472012471	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
504472012472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472012473	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472012474	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
504472012475	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
504472012476	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
504472012477	homodimer interface [polypeptide binding]; other site
504472012478	active site
504472012479	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
504472012480	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
504472012481	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472012482	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472012483	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
504472012484	Cell division protein FtsA; Region: FtsA; smart00842
504472012485	Cell division protein FtsA; Region: FtsA; pfam14450
504472012486	cell division protein FtsZ; Validated; Region: PRK09330
504472012487	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
504472012488	nucleotide binding site [chemical binding]; other site
504472012489	SulA interaction site; other site
504472012490	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
504472012491	A new structural DNA glycosylase; Region: AlkD_like; cd06561
504472012492	active site
504472012493	signal recognition particle protein; Provisional; Region: PRK10867
504472012494	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
504472012495	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
504472012496	P loop; other site
504472012497	GTP binding site [chemical binding]; other site
504472012498	Signal peptide binding domain; Region: SRP_SPB; pfam02978
504472012499	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472012500	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472012501	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472012502	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472012503	SusD family; Region: SusD; pfam07980
504472012504	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
504472012505	putative catalytic site [active]
504472012506	putative metal binding site [ion binding]; other site
504472012507	putative phosphate binding site [ion binding]; other site
504472012508	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
504472012509	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
504472012510	putative metal binding site [ion binding]; other site
504472012511	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472012512	isocitrate dehydrogenase; Validated; Region: PRK08299
504472012513	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
504472012514	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
504472012515	catalytic core [active]
504472012516	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472012517	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472012518	PA14 domain; Region: PA14; cl08459
504472012519	Cytochrome c; Region: Cytochrom_C; cl11414
504472012520	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
504472012521	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
504472012522	dimer interface [polypeptide binding]; other site
504472012523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472012524	catalytic residue [active]
504472012525	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
504472012526	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472012527	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472012528	catalytic residues [active]
504472012529	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
504472012530	active site
504472012531	catalytic triad [active]
504472012532	oxyanion hole [active]
504472012533	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472012534	HEAT repeats; Region: HEAT_2; pfam13646
504472012535	Cytochrome c; Region: Cytochrom_C; cl11414
504472012536	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
504472012537	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472012538	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472012539	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
504472012540	DNA binding residues [nucleotide binding]
504472012541	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472012542	FecR protein; Region: FecR; pfam04773
504472012543	Secretin and TonB N terminus short domain; Region: STN; pfam07660
504472012544	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472012545	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472012546	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472012547	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472012548	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472012549	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472012550	SusD family; Region: SusD; pfam07980
504472012551	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
504472012552	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
504472012553	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
504472012554	galactarate dehydratase; Region: galactar-dH20; TIGR03248
504472012555	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
504472012556	Glucuronate isomerase; Region: UxaC; pfam02614
504472012557	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
504472012558	putative pectinesterase; Region: PLN02432; cl01911
504472012559	Pectinesterase; Region: Pectinesterase; pfam01095
504472012560	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
504472012561	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
504472012562	active site
504472012563	short chain dehydrogenase; Provisional; Region: PRK08263
504472012564	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
504472012565	NADP binding site [chemical binding]; other site
504472012566	active site
504472012567	steroid binding site; other site
504472012568	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472012569	trehalose synthase; Region: treS_nterm; TIGR02456
504472012570	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
504472012571	active site
504472012572	catalytic site [active]
504472012573	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
504472012574	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
504472012575	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
504472012576	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
504472012577	active site
504472012578	homotetramer interface [polypeptide binding]; other site
504472012579	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472012580	active site
504472012581	motif I; other site
504472012582	motif II; other site
504472012583	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472012584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012585	active site
504472012586	phosphorylation site [posttranslational modification]
504472012587	intermolecular recognition site; other site
504472012588	dimerization interface [polypeptide binding]; other site
504472012589	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472012590	DNA binding site [nucleotide binding]
504472012591	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
504472012592	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
504472012593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472012594	dimer interface [polypeptide binding]; other site
504472012595	phosphorylation site [posttranslational modification]
504472012596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472012597	ATP binding site [chemical binding]; other site
504472012598	Mg2+ binding site [ion binding]; other site
504472012599	G-X-G motif; other site
504472012600	Domain of unknown function (DUF389); Region: DUF389; pfam04087
504472012601	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
504472012602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472012603	binding surface
504472012604	TPR motif; other site
504472012605	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472012606	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472012607	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472012608	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472012609	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472012610	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472012611	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
504472012612	classical (c) SDRs; Region: SDR_c; cd05233
504472012613	NAD(P) binding site [chemical binding]; other site
504472012614	active site
504472012615	Uncharacterized conserved protein [Function unknown]; Region: COG2128
504472012616	methionine aminotransferase; Validated; Region: PRK09082
504472012617	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472012618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472012619	homodimer interface [polypeptide binding]; other site
504472012620	catalytic residue [active]
504472012621	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
504472012622	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
504472012623	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472012624	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472012625	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
504472012626	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472012627	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472012628	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472012629	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
504472012630	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472012631	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
504472012632	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
504472012633	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
504472012634	active site
504472012635	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
504472012636	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
504472012637	NADP binding site [chemical binding]; other site
504472012638	active site
504472012639	putative substrate binding site [chemical binding]; other site
504472012640	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
504472012641	active site
504472012642	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472012643	Walker A/P-loop; other site
504472012644	ATP binding site [chemical binding]; other site
504472012645	ABC transporter; Region: ABC_tran; pfam00005
504472012646	Q-loop/lid; other site
504472012647	ABC transporter signature motif; other site
504472012648	Walker B; other site
504472012649	D-loop; other site
504472012650	H-loop/switch region; other site
504472012651	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
504472012652	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
504472012653	active site
504472012654	substrate binding site [chemical binding]; other site
504472012655	cosubstrate binding site; other site
504472012656	catalytic site [active]
504472012657	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
504472012658	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472012659	non-specific DNA binding site [nucleotide binding]; other site
504472012660	salt bridge; other site
504472012661	sequence-specific DNA binding site [nucleotide binding]; other site
504472012662	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472012663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012664	active site
504472012665	phosphorylation site [posttranslational modification]
504472012666	intermolecular recognition site; other site
504472012667	dimerization interface [polypeptide binding]; other site
504472012668	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472012669	DNA binding residues [nucleotide binding]
504472012670	dimerization interface [polypeptide binding]; other site
504472012671	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472012672	Two component regulator propeller; Region: Reg_prop; pfam07494
504472012673	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
504472012674	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472012675	Histidine kinase; Region: HisKA_3; pfam07730
504472012676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472012677	ATP binding site [chemical binding]; other site
504472012678	Mg2+ binding site [ion binding]; other site
504472012679	G-X-G motif; other site
504472012680	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
504472012681	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
504472012682	multiple promoter invertase; Provisional; Region: mpi; PRK13413
504472012683	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
504472012684	catalytic residues [active]
504472012685	catalytic nucleophile [active]
504472012686	Presynaptic Site I dimer interface [polypeptide binding]; other site
504472012687	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
504472012688	Synaptic Flat tetramer interface [polypeptide binding]; other site
504472012689	Synaptic Site I dimer interface [polypeptide binding]; other site
504472012690	DNA binding site [nucleotide binding]
504472012691	HTH domain; Region: HTH_22; pfam13309
504472012692	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472012693	binding surface
504472012694	TPR motif; other site
504472012695	TPR repeat; Region: TPR_11; pfam13414
504472012696	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
504472012697	GIY-YIG motif/motif A; other site
504472012698	active site
504472012699	catalytic site [active]
504472012700	metal binding site [ion binding]; metal-binding site
504472012701	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
504472012702	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
504472012703	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
504472012704	Methyltransferase domain; Region: Methyltransf_26; pfam13659
504472012705	TIGR02687 family protein; Region: TIGR02687
504472012706	PglZ domain; Region: PglZ; pfam08665
504472012707	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
504472012708	MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685
504472012709	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472012710	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472012711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472012712	Integrase core domain; Region: rve; pfam00665
504472012713	transposase/IS protein; Provisional; Region: PRK09183
504472012714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472012715	Walker A motif; other site
504472012716	ATP binding site [chemical binding]; other site
504472012717	Walker B motif; other site
504472012718	arginine finger; other site
504472012719	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472012720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472012721	Walker A motif; other site
504472012722	ATP binding site [chemical binding]; other site
504472012723	Walker B motif; other site
504472012724	arginine finger; other site
504472012725	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
504472012726	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
504472012727	active site
504472012728	NTP binding site [chemical binding]; other site
504472012729	metal binding triad [ion binding]; metal-binding site
504472012730	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
504472012731	active site
504472012732	NTP binding site [chemical binding]; other site
504472012733	metal binding triad [ion binding]; metal-binding site
504472012734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472012735	non-specific DNA binding site [nucleotide binding]; other site
504472012736	salt bridge; other site
504472012737	sequence-specific DNA binding site [nucleotide binding]; other site
504472012738	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
504472012739	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
504472012740	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
504472012741	Caspase domain; Region: Peptidase_C14; pfam00656
504472012742	ski2-like helicase; Provisional; Region: PRK02362
504472012743	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472012744	ATP binding site [chemical binding]; other site
504472012745	putative Mg++ binding site [ion binding]; other site
504472012746	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472012747	nucleotide binding region [chemical binding]; other site
504472012748	ATP-binding site [chemical binding]; other site
504472012749	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472012750	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
504472012751	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472012752	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472012753	metal binding site [ion binding]; metal-binding site
504472012754	Histidine kinase; Region: His_kinase; pfam06580
504472012755	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472012756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472012757	cell density-dependent motility repressor; Provisional; Region: PRK10082
504472012758	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
504472012759	putative dimerization interface [polypeptide binding]; other site
504472012760	DsrE/DsrF-like family; Region: DrsE; cl00672
504472012761	Cytochrome c [Energy production and conversion]; Region: COG3258
504472012762	Cytochrome c; Region: Cytochrom_C; pfam00034
504472012763	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
504472012764	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
504472012765	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
504472012766	Zn binding site [ion binding]; other site
504472012767	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
504472012768	four helix bundle protein; Region: TIGR02436
504472012769	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
504472012770	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
504472012771	Walker A/P-loop; other site
504472012772	ATP binding site [chemical binding]; other site
504472012773	Q-loop/lid; other site
504472012774	ABC transporter signature motif; other site
504472012775	Walker B; other site
504472012776	D-loop; other site
504472012777	H-loop/switch region; other site
504472012778	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
504472012779	Peptidase family M48; Region: Peptidase_M48; pfam01435
504472012780	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472012781	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472012782	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
504472012783	Putative Ig domain; Region: He_PIG; pfam05345
504472012784	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
504472012785	Cadherin repeat-like domain; Region: CA_like; cl15786
504472012786	Ca2+ binding site [ion binding]; other site
504472012787	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
504472012788	DNA polymerase III subunit beta; Validated; Region: PRK05643
504472012789	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
504472012790	putative DNA binding surface [nucleotide binding]; other site
504472012791	dimer interface [polypeptide binding]; other site
504472012792	beta-clamp/clamp loader binding surface; other site
504472012793	beta-clamp/translesion DNA polymerase binding surface; other site
504472012794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472012795	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472012796	putative substrate translocation pore; other site
504472012797	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472012798	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472012799	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
504472012800	YceI-like domain; Region: YceI; pfam04264
504472012801	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
504472012802	iron-sulfur cluster [ion binding]; other site
504472012803	[2Fe-2S] cluster binding site [ion binding]; other site
504472012804	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472012805	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472012806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472012807	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472012808	DNA binding residues [nucleotide binding]
504472012809	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
504472012810	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
504472012811	Uncharacterized conserved protein [Function unknown]; Region: COG4850
504472012812	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
504472012813	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472012814	homotrimer interaction site [polypeptide binding]; other site
504472012815	putative active site [active]
504472012816	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
504472012817	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
504472012818	HIGH motif; other site
504472012819	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
504472012820	active site
504472012821	KMSKS motif; other site
504472012822	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
504472012823	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
504472012824	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472012825	Cytochrome c; Region: Cytochrom_C; pfam00034
504472012826	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472012827	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472012828	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
504472012829	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
504472012830	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
504472012831	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
504472012832	Asp-box motif; other site
504472012833	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
504472012834	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
504472012835	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
504472012836	mce related protein; Region: MCE; pfam02470
504472012837	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
504472012838	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
504472012839	active site
504472012840	metal binding site [ion binding]; metal-binding site
504472012841	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
504472012842	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
504472012843	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
504472012844	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472012845	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
504472012846	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472012847	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
504472012848	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
504472012849	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
504472012850	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
504472012851	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
504472012852	4Fe-4S binding domain; Region: Fer4; pfam00037
504472012853	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
504472012854	4Fe-4S binding domain; Region: Fer4; pfam00037
504472012855	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
504472012856	tetramer interface [polypeptide binding]; other site
504472012857	TPP-binding site [chemical binding]; other site
504472012858	heterodimer interface [polypeptide binding]; other site
504472012859	phosphorylation loop region [posttranslational modification]
504472012860	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
504472012861	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
504472012862	PYR/PP interface [polypeptide binding]; other site
504472012863	dimer interface [polypeptide binding]; other site
504472012864	TPP binding site [chemical binding]; other site
504472012865	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
504472012866	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
504472012867	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
504472012868	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
504472012869	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
504472012870	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472012871	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472012872	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472012873	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
504472012874	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
504472012875	Bacterial sugar transferase; Region: Bac_transf; pfam02397
504472012876	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
504472012877	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472012878	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
504472012879	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
504472012880	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472012881	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
504472012882	active site
504472012883	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
504472012884	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
504472012885	Probable Catalytic site; other site
504472012886	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472012887	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
504472012888	active site
504472012889	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
504472012890	metal-binding site
504472012891	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472012892	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
504472012893	metal-binding site
504472012894	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472012895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472012896	S-adenosylmethionine binding site [chemical binding]; other site
504472012897	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472012898	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
504472012899	Chain length determinant protein; Region: Wzz; cl15801
504472012900	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
504472012901	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472012902	SLBB domain; Region: SLBB; pfam10531
504472012903	SLBB domain; Region: SLBB; pfam10531
504472012904	SLBB domain; Region: SLBB; pfam10531
504472012905	SLBB domain; Region: SLBB; pfam10531
504472012906	SLBB domain; Region: SLBB; pfam10531
504472012907	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
504472012908	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
504472012909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472012910	nucleotide binding region [chemical binding]; other site
504472012911	ATP-binding site [chemical binding]; other site
504472012912	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472012913	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472012914	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
504472012915	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
504472012916	dimer interface [polypeptide binding]; other site
504472012917	active site
504472012918	CoA binding pocket [chemical binding]; other site
504472012919	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
504472012920	Zn binding site [ion binding]; other site
504472012921	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
504472012922	Subunit I/III interface [polypeptide binding]; other site
504472012923	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
504472012924	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
504472012925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472012926	binding surface
504472012927	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472012928	TPR motif; other site
504472012929	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472012930	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472012931	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472012932	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472012933	ligand binding site [chemical binding]; other site
504472012934	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472012935	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
504472012936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472012937	Walker A/P-loop; other site
504472012938	ATP binding site [chemical binding]; other site
504472012939	Q-loop/lid; other site
504472012940	ABC transporter signature motif; other site
504472012941	Walker B; other site
504472012942	D-loop; other site
504472012943	H-loop/switch region; other site
504472012944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472012945	Walker A/P-loop; other site
504472012946	ATP binding site [chemical binding]; other site
504472012947	Q-loop/lid; other site
504472012948	ABC transporter signature motif; other site
504472012949	Walker B; other site
504472012950	D-loop; other site
504472012951	H-loop/switch region; other site
504472012952	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472012953	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
504472012954	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472012955	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472012956	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
504472012957	SdiA-regulated; Region: SdiA-regulated; cd09971
504472012958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
504472012959	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
504472012960	Response regulator receiver domain; Region: Response_reg; pfam00072
504472012961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472012962	active site
504472012963	phosphorylation site [posttranslational modification]
504472012964	intermolecular recognition site; other site
504472012965	dimerization interface [polypeptide binding]; other site
504472012966	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472012967	MG2 domain; Region: A2M_N; pfam01835
504472012968	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472012969	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472012970	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
504472012971	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
504472012972	putative active site [active]
504472012973	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
504472012974	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
504472012975	metal binding site [ion binding]; metal-binding site
504472012976	dimer interface [polypeptide binding]; other site
504472012977	RDD family; Region: RDD; pfam06271
504472012978	Integral membrane protein DUF95; Region: DUF95; pfam01944
504472012979	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
504472012980	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
504472012981	MoxR-like ATPases [General function prediction only]; Region: COG0714
504472012982	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
504472012983	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
504472012984	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
504472012985	Protein of unknown function DUF58; Region: DUF58; pfam01882
504472012986	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472012987	putative active site [active]
504472012988	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
504472012989	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
504472012990	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
504472012991	dimer interface [polypeptide binding]; other site
504472012992	active site
504472012993	glycine-pyridoxal phosphate binding site [chemical binding]; other site
504472012994	folate binding site [chemical binding]; other site
504472012995	Cupin domain; Region: Cupin_2; pfam07883
504472012996	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472012997	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472012998	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
504472012999	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
504472013000	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
504472013001	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
504472013002	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
504472013003	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472013004	Low molecular weight phosphatase family; Region: LMWPc; cl00105
504472013005	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
504472013006	active site
504472013007	Secretory lipase; Region: LIP; pfam03583
504472013008	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472013009	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
504472013010	putative catalytic site [active]
504472013011	putative metal binding site [ion binding]; other site
504472013012	putative phosphate binding site [ion binding]; other site
504472013013	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472013014	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472013015	active site
504472013016	metal binding site [ion binding]; metal-binding site
504472013017	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472013018	SusD family; Region: SusD; pfam07980
504472013019	Secretin and TonB N terminus short domain; Region: STN; pfam07660
504472013020	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472013021	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013022	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472013023	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472013024	FecR protein; Region: FecR; pfam04773
504472013025	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472013026	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472013027	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472013028	DNA binding residues [nucleotide binding]
504472013029	Sphingolipid Delta4-desaturase (DES); Region: Lipid_DES; pfam08557
504472013030	sphingolipid delta-4 desaturase; Region: PLN02579
504472013031	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
504472013032	putative di-iron ligands [ion binding]; other site
504472013033	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472013034	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
504472013035	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
504472013036	putative acyl-acceptor binding pocket; other site
504472013037	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
504472013038	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
504472013039	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
504472013040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472013041	FeS/SAM binding site; other site
504472013042	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013043	Colicin V production protein; Region: Colicin_V; pfam02674
504472013044	Yqey-like protein; Region: YqeY; pfam09424
504472013045	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
504472013046	active site
504472013047	hydrophilic channel; other site
504472013048	dimerization interface [polypeptide binding]; other site
504472013049	catalytic residues [active]
504472013050	active site lid [active]
504472013051	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
504472013052	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
504472013053	active site residue [active]
504472013054	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
504472013055	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
504472013056	peptide chain release factor 1; Validated; Region: prfA; PRK00591
504472013057	PCRF domain; Region: PCRF; pfam03462
504472013058	RF-1 domain; Region: RF-1; pfam00472
504472013059	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472013060	Sulfatase; Region: Sulfatase; pfam00884
504472013061	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472013062	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472013063	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472013064	HEAT repeats; Region: HEAT_2; pfam13646
504472013065	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472013066	Cytochrome c; Region: Cytochrom_C; pfam00034
504472013067	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472013068	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472013069	Cytochrome c; Region: Cytochrom_C; cl11414
504472013070	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472013071	Sulfatase; Region: Sulfatase; pfam00884
504472013072	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472013073	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
504472013074	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
504472013075	Predicted membrane protein [Function unknown]; Region: COG2246
504472013076	GtrA-like protein; Region: GtrA; pfam04138
504472013077	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
504472013078	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
504472013079	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
504472013080	L-aspartate oxidase; Provisional; Region: PRK06175
504472013081	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
504472013082	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
504472013083	putative Iron-sulfur protein interface [polypeptide binding]; other site
504472013084	proximal heme binding site [chemical binding]; other site
504472013085	distal heme binding site [chemical binding]; other site
504472013086	putative dimer interface [polypeptide binding]; other site
504472013087	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
504472013088	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
504472013089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
504472013090	non-specific DNA binding site [nucleotide binding]; other site
504472013091	salt bridge; other site
504472013092	Trehalase; Region: Trehalase; cl17346
504472013093	trehalase; Provisional; Region: treF; PRK13270
504472013094	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
504472013095	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
504472013096	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
504472013097	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
504472013098	domain interfaces; other site
504472013099	active site
504472013100	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472013101	Coenzyme A binding pocket [chemical binding]; other site
504472013102	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472013103	FtsX-like permease family; Region: FtsX; pfam02687
504472013104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013105	active site
504472013106	phosphorylation site [posttranslational modification]
504472013107	intermolecular recognition site; other site
504472013108	dimerization interface [polypeptide binding]; other site
504472013109	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
504472013110	cyclase homology domain; Region: CHD; cd07302
504472013111	nucleotidyl binding site; other site
504472013112	metal binding site [ion binding]; metal-binding site
504472013113	dimer interface [polypeptide binding]; other site
504472013114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013115	Response regulator receiver domain; Region: Response_reg; pfam00072
504472013116	active site
504472013117	phosphorylation site [posttranslational modification]
504472013118	intermolecular recognition site; other site
504472013119	dimerization interface [polypeptide binding]; other site
504472013120	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
504472013121	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472013122	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472013123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472013124	dimer interface [polypeptide binding]; other site
504472013125	phosphorylation site [posttranslational modification]
504472013126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472013127	ATP binding site [chemical binding]; other site
504472013128	Mg2+ binding site [ion binding]; other site
504472013129	G-X-G motif; other site
504472013130	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472013131	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472013132	ligand binding site [chemical binding]; other site
504472013133	flexible hinge region; other site
504472013134	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
504472013135	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
504472013136	Sulfate transporter family; Region: Sulfate_transp; pfam00916
504472013137	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
504472013138	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
504472013139	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
504472013140	TPP-binding site [chemical binding]; other site
504472013141	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
504472013142	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472013143	E3 interaction surface; other site
504472013144	lipoyl attachment site [posttranslational modification]; other site
504472013145	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
504472013146	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
504472013147	E3 interaction surface; other site
504472013148	lipoyl attachment site [posttranslational modification]; other site
504472013149	e3 binding domain; Region: E3_binding; pfam02817
504472013150	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
504472013151	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
504472013152	phosphoglyceromutase; Provisional; Region: PRK05434
504472013153	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
504472013154	Low molecular weight phosphatase family; Region: LMWPc; cd00115
504472013155	active site
504472013156	Septum formation initiator; Region: DivIC; cl17659
504472013157	enolase; Provisional; Region: eno; PRK00077
504472013158	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
504472013159	dimer interface [polypeptide binding]; other site
504472013160	metal binding site [ion binding]; metal-binding site
504472013161	substrate binding pocket [chemical binding]; other site
504472013162	recombinase A; Provisional; Region: recA; PRK09354
504472013163	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
504472013164	hexamer interface [polypeptide binding]; other site
504472013165	Walker A motif; other site
504472013166	ATP binding site [chemical binding]; other site
504472013167	Walker B motif; other site
504472013168	Transposase IS200 like; Region: Y1_Tnp; cl00848
504472013169	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
504472013170	dimer interface [polypeptide binding]; other site
504472013171	Citrate synthase; Region: Citrate_synt; pfam00285
504472013172	active site
504472013173	citrylCoA binding site [chemical binding]; other site
504472013174	NADH binding [chemical binding]; other site
504472013175	cationic pore residues; other site
504472013176	oxalacetate/citrate binding site [chemical binding]; other site
504472013177	coenzyme A binding site [chemical binding]; other site
504472013178	catalytic triad [active]
504472013179	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
504472013180	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472013181	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
504472013182	active site
504472013183	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
504472013184	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
504472013185	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
504472013186	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
504472013187	HNH endonuclease; Region: HNH_2; pfam13391
504472013188	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
504472013189	dimer interface [polypeptide binding]; other site
504472013190	putative radical transfer pathway; other site
504472013191	diiron center [ion binding]; other site
504472013192	tyrosyl radical; other site
504472013193	Methyltransferase domain; Region: Methyltransf_24; pfam13578
504472013194	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472013195	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
504472013196	Probable Catalytic site; other site
504472013197	metal-binding site
504472013198	RecX family; Region: RecX; pfam02631
504472013199	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
504472013200	active site
504472013201	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
504472013202	Predicted membrane protein [Function unknown]; Region: COG4270
504472013203	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
504472013204	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
504472013205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472013206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472013207	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
504472013208	active site
504472013209	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472013210	Family description; Region: VCBS; pfam13517
504472013211	Family description; Region: VCBS; pfam13517
504472013212	Family description; Region: VCBS; pfam13517
504472013213	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472013214	Family description; Region: VCBS; pfam13517
504472013215	Family description; Region: VCBS; pfam13517
504472013216	Family description; Region: VCBS; pfam13517
504472013217	Family description; Region: VCBS; pfam13517
504472013218	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472013219	Family description; Region: VCBS; pfam13517
504472013220	Family description; Region: VCBS; pfam13517
504472013221	Family description; Region: VCBS; pfam13517
504472013222	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472013223	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472013224	SusD family; Region: SusD; pfam07980
504472013225	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472013226	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013227	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472013228	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472013229	Family description; Region: VCBS; pfam13517
504472013230	Family description; Region: VCBS; pfam13517
504472013231	Family description; Region: VCBS; pfam13517
504472013232	Family description; Region: VCBS; pfam13517
504472013233	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472013234	Family description; Region: VCBS; pfam13517
504472013235	Family description; Region: VCBS; pfam13517
504472013236	Family description; Region: VCBS; pfam13517
504472013237	Family description; Region: VCBS; pfam13517
504472013238	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472013239	SusD family; Region: SusD; pfam07980
504472013240	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472013241	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013242	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472013243	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472013244	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
504472013245	FAD binding domain; Region: FAD_binding_4; pfam01565
504472013246	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
504472013247	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
504472013248	active site
504472013249	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472013250	Interdomain contacts; other site
504472013251	Cytokine receptor motif; other site
504472013252	Domain of unknown function DUF11; Region: DUF11; cl17728
504472013253	Domain of unknown function DUF11; Region: DUF11; pfam01345
504472013254	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
504472013255	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013256	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472013257	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472013258	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472013259	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472013260	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472013261	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
504472013262	Acyltransferase family; Region: Acyl_transf_3; pfam01757
504472013263	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
504472013264	ApbE family; Region: ApbE; pfam02424
504472013265	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472013266	putative active site [active]
504472013267	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
504472013268	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
504472013269	Tetramer interface [polypeptide binding]; other site
504472013270	active site
504472013271	FMN-binding site [chemical binding]; other site
504472013272	Oxygen tolerance; Region: BatD; pfam13584
504472013273	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
504472013274	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
504472013275	Beta-Casp domain; Region: Beta-Casp; smart01027
504472013276	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
504472013277	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
504472013278	Transglycosylase; Region: Transgly; pfam00912
504472013279	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
504472013280	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
504472013281	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
504472013282	MG2 domain; Region: A2M_N; pfam01835
504472013283	Alpha-2-macroglobulin family; Region: A2M; pfam00207
504472013284	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
504472013285	surface patch; other site
504472013286	thioester region; other site
504472013287	specificity defining residues; other site
504472013288	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
504472013289	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
504472013290	trimer interface [polypeptide binding]; other site
504472013291	putative metal binding site [ion binding]; other site
504472013292	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
504472013293	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
504472013294	Zn binding site [ion binding]; other site
504472013295	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
504472013296	Zn binding site [ion binding]; other site
504472013297	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
504472013298	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472013299	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
504472013300	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
504472013301	dimer interface [polypeptide binding]; other site
504472013302	active site
504472013303	heme binding site [chemical binding]; other site
504472013304	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
504472013305	Response regulator receiver domain; Region: Response_reg; pfam00072
504472013306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013307	active site
504472013308	phosphorylation site [posttranslational modification]
504472013309	intermolecular recognition site; other site
504472013310	dimerization interface [polypeptide binding]; other site
504472013311	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
504472013312	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
504472013313	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
504472013314	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472013315	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
504472013316	PBP superfamily domain; Region: PBP_like_2; pfam12849
504472013317	TPR repeat; Region: TPR_11; pfam13414
504472013318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472013319	binding surface
504472013320	TPR motif; other site
504472013321	adenylate kinase; Reviewed; Region: adk; PRK00279
504472013322	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
504472013323	AMP-binding site [chemical binding]; other site
504472013324	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
504472013325	GTPase CgtA; Reviewed; Region: obgE; PRK12299
504472013326	GTP1/OBG; Region: GTP1_OBG; pfam01018
504472013327	Obg GTPase; Region: Obg; cd01898
504472013328	G1 box; other site
504472013329	GTP/Mg2+ binding site [chemical binding]; other site
504472013330	Switch I region; other site
504472013331	G2 box; other site
504472013332	G3 box; other site
504472013333	Switch II region; other site
504472013334	G4 box; other site
504472013335	G5 box; other site
504472013336	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472013337	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472013338	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472013339	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
504472013340	NADH dehydrogenase subunit B; Provisional; Region: PRK14820
504472013341	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
504472013342	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
504472013343	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
504472013344	NADH dehydrogenase subunit D; Validated; Region: PRK06075
504472013345	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
504472013346	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
504472013347	putative dimer interface [polypeptide binding]; other site
504472013348	[2Fe-2S] cluster binding site [ion binding]; other site
504472013349	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
504472013350	SLBB domain; Region: SLBB; pfam10531
504472013351	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
504472013352	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472013353	catalytic loop [active]
504472013354	iron binding site [ion binding]; other site
504472013355	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
504472013356	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
504472013357	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
504472013358	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
504472013359	NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499
504472013360	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
504472013361	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
504472013362	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
504472013363	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
504472013364	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
504472013365	dimer interface [polypeptide binding]; other site
504472013366	active site
504472013367	allantoate amidohydrolase; Reviewed; Region: PRK09290
504472013368	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
504472013369	active site
504472013370	metal binding site [ion binding]; metal-binding site
504472013371	dimer interface [polypeptide binding]; other site
504472013372	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
504472013373	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
504472013374	active site
504472013375	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
504472013376	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472013377	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472013378	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472013379	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472013380	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472013381	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472013382	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472013383	Walker A/P-loop; other site
504472013384	ATP binding site [chemical binding]; other site
504472013385	Q-loop/lid; other site
504472013386	ABC transporter signature motif; other site
504472013387	Walker B; other site
504472013388	D-loop; other site
504472013389	H-loop/switch region; other site
504472013390	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472013391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472013392	binding surface
504472013393	TPR motif; other site
504472013394	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
504472013395	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472013396	PQQ-like domain; Region: PQQ_2; pfam13360
504472013397	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
504472013398	Trp docking motif [polypeptide binding]; other site
504472013399	active site
504472013400	4-alpha-glucanotransferase; Provisional; Region: PRK14508
504472013401	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
504472013402	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
504472013403	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
504472013404	alpha subunit interaction interface [polypeptide binding]; other site
504472013405	Walker A motif; other site
504472013406	ATP binding site [chemical binding]; other site
504472013407	Walker B motif; other site
504472013408	inhibitor binding site; inhibition site
504472013409	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
504472013410	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
504472013411	gamma subunit interface [polypeptide binding]; other site
504472013412	epsilon subunit interface [polypeptide binding]; other site
504472013413	LBP interface [polypeptide binding]; other site
504472013414	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
504472013415	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
504472013416	ATP-binding site [chemical binding]; other site
504472013417	Sugar specificity; other site
504472013418	Pyrimidine base specificity; other site
504472013419	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
504472013420	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
504472013421	FAD binding pocket [chemical binding]; other site
504472013422	FAD binding motif [chemical binding]; other site
504472013423	phosphate binding motif [ion binding]; other site
504472013424	beta-alpha-beta structure motif; other site
504472013425	NAD(p) ribose binding residues [chemical binding]; other site
504472013426	NAD binding pocket [chemical binding]; other site
504472013427	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
504472013428	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472013429	catalytic loop [active]
504472013430	iron binding site [ion binding]; other site
504472013431	quinolinate synthetase; Provisional; Region: PRK09375
504472013432	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
504472013433	L-aspartate oxidase; Provisional; Region: PRK09077
504472013434	L-aspartate oxidase; Provisional; Region: PRK06175
504472013435	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
504472013436	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472013437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013438	active site
504472013439	phosphorylation site [posttranslational modification]
504472013440	intermolecular recognition site; other site
504472013441	dimerization interface [polypeptide binding]; other site
504472013442	LytTr DNA-binding domain; Region: LytTR; smart00850
504472013443	CAAX protease self-immunity; Region: Abi; pfam02517
504472013444	Histidine kinase; Region: His_kinase; pfam06580
504472013445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
504472013446	ATP binding site [chemical binding]; other site
504472013447	Mg2+ binding site [ion binding]; other site
504472013448	G-X-G motif; other site
504472013449	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
504472013450	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
504472013451	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472013452	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472013453	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472013454	DNA binding residues [nucleotide binding]
504472013455	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
504472013456	dimer interface [polypeptide binding]; other site
504472013457	YHYH protein; Region: YHYH; pfam14240
504472013458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
504472013459	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
504472013460	Cu(I) binding site [ion binding]; other site
504472013461	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
504472013462	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
504472013463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472013464	acyl carrier protein; Provisional; Region: acpP; PRK00982
504472013465	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
504472013466	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
504472013467	dimer interface [polypeptide binding]; other site
504472013468	active site
504472013469	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
504472013470	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
504472013471	dimerization interface [polypeptide binding]; other site
504472013472	active site
504472013473	metal binding site [ion binding]; metal-binding site
504472013474	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
504472013475	dsRNA binding site [nucleotide binding]; other site
504472013476	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
504472013477	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
504472013478	putative dimer interface [polypeptide binding]; other site
504472013479	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
504472013480	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
504472013481	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
504472013482	protein binding site [polypeptide binding]; other site
504472013483	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
504472013484	protein binding site [polypeptide binding]; other site
504472013485	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
504472013486	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
504472013487	NADP-binding site; other site
504472013488	homotetramer interface [polypeptide binding]; other site
504472013489	substrate binding site [chemical binding]; other site
504472013490	homodimer interface [polypeptide binding]; other site
504472013491	active site
504472013492	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
504472013493	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
504472013494	FAD binding domain; Region: FAD_binding_4; pfam01565
504472013495	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
504472013496	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
504472013497	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
504472013498	nucleotide binding site [chemical binding]; other site
504472013499	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
504472013500	classical (c) SDRs; Region: SDR_c; cd05233
504472013501	NAD(P) binding site [chemical binding]; other site
504472013502	active site
504472013503	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
504472013504	Permease; Region: Permease; pfam02405
504472013505	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
504472013506	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
504472013507	Walker A/P-loop; other site
504472013508	ATP binding site [chemical binding]; other site
504472013509	Q-loop/lid; other site
504472013510	ABC transporter signature motif; other site
504472013511	Walker B; other site
504472013512	D-loop; other site
504472013513	H-loop/switch region; other site
504472013514	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
504472013515	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
504472013516	thymidine kinase; Provisional; Region: PRK04296
504472013517	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472013518	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472013519	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472013520	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
504472013521	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
504472013522	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
504472013523	alpha subunit interface [polypeptide binding]; other site
504472013524	TPP binding site [chemical binding]; other site
504472013525	heterodimer interface [polypeptide binding]; other site
504472013526	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
504472013527	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
504472013528	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
504472013529	dimerization interface [polypeptide binding]; other site
504472013530	active site
504472013531	Protein of unknown function (DUF3260); Region: DUF3260; cl11881
504472013532	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
504472013533	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
504472013534	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
504472013535	Protein export membrane protein; Region: SecD_SecF; pfam02355
504472013536	amino acid transporter; Region: 2A0306; TIGR00909
504472013537	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
504472013538	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
504472013539	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
504472013540	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472013541	active site residue [active]
504472013542	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472013543	active site residue [active]
504472013544	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
504472013545	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
504472013546	DNA binding residues [nucleotide binding]
504472013547	B12 binding domain; Region: B12-binding_2; pfam02607
504472013548	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
504472013549	Cupin domain; Region: Cupin_2; cl17218
504472013550	Cupin domain; Region: Cupin_2; cl17218
504472013551	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
504472013552	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
504472013553	Ligand binding site; other site
504472013554	Putative Catalytic site; other site
504472013555	DXD motif; other site
504472013556	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472013557	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472013558	active site
504472013559	catalytic tetrad [active]
504472013560	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
504472013561	active site
504472013562	iron coordination sites [ion binding]; other site
504472013563	substrate binding pocket [chemical binding]; other site
504472013564	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472013565	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
504472013566	active site
504472013567	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472013568	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472013569	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
504472013570	NAD binding site [chemical binding]; other site
504472013571	homotetramer interface [polypeptide binding]; other site
504472013572	homodimer interface [polypeptide binding]; other site
504472013573	active site
504472013574	substrate binding site [chemical binding]; other site
504472013575	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
504472013576	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
504472013577	active site
504472013578	Zn binding site [ion binding]; other site
504472013579	Penicillinase repressor; Region: Pencillinase_R; pfam03965
504472013580	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
504472013581	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
504472013582	Domain of unknown function (DUF4200); Region: DUF4200; pfam13863
504472013583	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
504472013584	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
504472013585	FAD binding pocket [chemical binding]; other site
504472013586	FAD binding motif [chemical binding]; other site
504472013587	phosphate binding motif [ion binding]; other site
504472013588	beta-alpha-beta structure motif; other site
504472013589	NAD(p) ribose binding residues [chemical binding]; other site
504472013590	NAD binding pocket [chemical binding]; other site
504472013591	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
504472013592	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472013593	catalytic loop [active]
504472013594	iron binding site [ion binding]; other site
504472013595	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
504472013596	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
504472013597	thiamine monophosphate kinase; Provisional; Region: PRK05731
504472013598	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
504472013599	ATP binding site [chemical binding]; other site
504472013600	dimerization interface [polypeptide binding]; other site
504472013601	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
504472013602	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
504472013603	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
504472013604	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
504472013605	Substrate binding site; other site
504472013606	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
504472013607	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472013608	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472013609	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472013610	Protein of unknown function (DUF952); Region: DUF952; pfam06108
504472013611	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472013612	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
504472013613	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
504472013614	active site
504472013615	TPR repeat; Region: TPR_11; pfam13414
504472013616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472013617	binding surface
504472013618	TPR motif; other site
504472013619	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472013620	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
504472013621	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472013622	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472013623	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472013624	ligand binding site [chemical binding]; other site
504472013625	glycine dehydrogenase; Provisional; Region: PRK05367
504472013626	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
504472013627	tetramer interface [polypeptide binding]; other site
504472013628	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472013629	catalytic residue [active]
504472013630	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
504472013631	tetramer interface [polypeptide binding]; other site
504472013632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472013633	catalytic residue [active]
504472013634	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
504472013635	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472013636	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472013637	putative active site [active]
504472013638	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472013639	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
504472013640	metal-binding site
504472013641	SlyX; Region: SlyX; cl01090
504472013642	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
504472013643	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
504472013644	Ligand binding site; other site
504472013645	Putative Catalytic site; other site
504472013646	DXD motif; other site
504472013647	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
504472013648	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
504472013649	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472013650	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013651	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
504472013652	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472013653	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472013654	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
504472013655	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
504472013656	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472013657	metal binding site [ion binding]; metal-binding site
504472013658	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
504472013659	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
504472013660	NAD binding site [chemical binding]; other site
504472013661	catalytic Zn binding site [ion binding]; other site
504472013662	structural Zn binding site [ion binding]; other site
504472013663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472013664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472013665	dimer interface [polypeptide binding]; other site
504472013666	phosphorylation site [posttranslational modification]
504472013667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472013668	ATP binding site [chemical binding]; other site
504472013669	Mg2+ binding site [ion binding]; other site
504472013670	G-X-G motif; other site
504472013671	Response regulator receiver domain; Region: Response_reg; pfam00072
504472013672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013673	active site
504472013674	phosphorylation site [posttranslational modification]
504472013675	intermolecular recognition site; other site
504472013676	dimerization interface [polypeptide binding]; other site
504472013677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472013678	Major Facilitator Superfamily; Region: MFS_1; pfam07690
504472013679	putative substrate translocation pore; other site
504472013680	Protein of unknown function (DUF3257); Region: DUF3257; pfam11645
504472013681	GTPase Era; Reviewed; Region: era; PRK00089
504472013682	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
504472013683	G1 box; other site
504472013684	GTP/Mg2+ binding site [chemical binding]; other site
504472013685	Switch I region; other site
504472013686	G2 box; other site
504472013687	Switch II region; other site
504472013688	G3 box; other site
504472013689	G4 box; other site
504472013690	G5 box; other site
504472013691	KH domain; Region: KH_2; pfam07650
504472013692	GTP-binding protein Der; Reviewed; Region: PRK00093
504472013693	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
504472013694	G1 box; other site
504472013695	GTP/Mg2+ binding site [chemical binding]; other site
504472013696	Switch I region; other site
504472013697	G2 box; other site
504472013698	Switch II region; other site
504472013699	G3 box; other site
504472013700	G4 box; other site
504472013701	G5 box; other site
504472013702	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
504472013703	G1 box; other site
504472013704	GTP/Mg2+ binding site [chemical binding]; other site
504472013705	Switch I region; other site
504472013706	G2 box; other site
504472013707	G3 box; other site
504472013708	Switch II region; other site
504472013709	G4 box; other site
504472013710	G5 box; other site
504472013711	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
504472013712	EamA-like transporter family; Region: EamA; pfam00892
504472013713	EamA-like transporter family; Region: EamA; pfam00892
504472013714	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472013715	dimerization interface [polypeptide binding]; other site
504472013716	putative DNA binding site [nucleotide binding]; other site
504472013717	putative Zn2+ binding site [ion binding]; other site
504472013718	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
504472013719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472013720	Walker A motif; other site
504472013721	ATP binding site [chemical binding]; other site
504472013722	Walker B motif; other site
504472013723	arginine finger; other site
504472013724	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
504472013725	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472013726	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472013727	Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519
504472013728	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
504472013729	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
504472013730	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472013731	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472013732	ABC transporter; Region: ABC_tran_2; pfam12848
504472013733	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
504472013734	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
504472013735	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
504472013736	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
504472013737	nudix motif; other site
504472013738	DinB superfamily; Region: DinB_2; pfam12867
504472013739	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
504472013740	Na binding site [ion binding]; other site
504472013741	putative glycosylation site [posttranslational modification]; other site
504472013742	putative glycosylation site [posttranslational modification]; other site
504472013743	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
504472013744	Family of unknown function (DUF706); Region: DUF706; pfam05153
504472013745	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472013746	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472013747	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
504472013748	Na binding site [ion binding]; other site
504472013749	substrate binding site [chemical binding]; other site
504472013750	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
504472013751	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
504472013752	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
504472013753	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
504472013754	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
504472013755	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
504472013756	carboxyltransferase (CT) interaction site; other site
504472013757	biotinylation site [posttranslational modification]; other site
504472013758	elongation factor P; Validated; Region: PRK00529
504472013759	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
504472013760	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
504472013761	RNA binding site [nucleotide binding]; other site
504472013762	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
504472013763	RNA binding site [nucleotide binding]; other site
504472013764	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
504472013765	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
504472013766	dimer interface [polypeptide binding]; other site
504472013767	active site
504472013768	CoA binding pocket [chemical binding]; other site
504472013769	putative phosphate acyltransferase; Provisional; Region: PRK05331
504472013770	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
504472013771	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
504472013772	EamA-like transporter family; Region: EamA; pfam00892
504472013773	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
504472013774	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472013775	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
504472013776	active site
504472013777	catalytic site [active]
504472013778	substrate binding site [chemical binding]; other site
504472013779	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472013780	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472013781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
504472013782	Histidine kinase; Region: HisKA_3; pfam07730
504472013783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472013784	ATP binding site [chemical binding]; other site
504472013785	Mg2+ binding site [ion binding]; other site
504472013786	G-X-G motif; other site
504472013787	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
504472013788	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472013789	Predicted membrane protein [Function unknown]; Region: COG2323
504472013790	Predicted membrane protein [Function unknown]; Region: COG2323
504472013791	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
504472013792	iron binding site [ion binding]; other site
504472013793	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
504472013794	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472013795	putative homodimer interface [polypeptide binding]; other site
504472013796	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
504472013797	Response regulator receiver domain; Region: Response_reg; pfam00072
504472013798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013799	active site
504472013800	phosphorylation site [posttranslational modification]
504472013801	intermolecular recognition site; other site
504472013802	dimerization interface [polypeptide binding]; other site
504472013803	CheB methylesterase; Region: CheB_methylest; pfam01339
504472013804	Response regulator receiver domain; Region: Response_reg; pfam00072
504472013805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472013806	active site
504472013807	phosphorylation site [posttranslational modification]
504472013808	intermolecular recognition site; other site
504472013809	dimerization interface [polypeptide binding]; other site
504472013810	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472013811	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472013812	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472013813	Interdomain contacts; other site
504472013814	Cytokine receptor motif; other site
504472013815	Homeodomain-like domain; Region: HTH_23; pfam13384
504472013816	Winged helix-turn helix; Region: HTH_29; pfam13551
504472013817	Homeodomain-like domain; Region: HTH_32; pfam13565
504472013818	Winged helix-turn helix; Region: HTH_33; pfam13592
504472013819	DDE superfamily endonuclease; Region: DDE_3; pfam13358
504472013820	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
504472013821	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
504472013822	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
504472013823	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472013824	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
504472013825	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
504472013826	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
504472013827	catalytic site [active]
504472013828	active site
504472013829	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
504472013830	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
504472013831	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
504472013832	active site
504472013833	catalytic site [active]
504472013834	4-alpha-glucanotransferase; Provisional; Region: PRK14508
504472013835	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
504472013836	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
504472013837	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
504472013838	dimer interface [polypeptide binding]; other site
504472013839	ADP-ribose binding site [chemical binding]; other site
504472013840	active site
504472013841	nudix motif; other site
504472013842	metal binding site [ion binding]; metal-binding site
504472013843	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
504472013844	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013845	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472013846	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472013847	N-terminal plug; other site
504472013848	ligand-binding site [chemical binding]; other site
504472013849	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
504472013850	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
504472013851	Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248
504472013852	active site
504472013853	S2 subsite; other site
504472013854	short chain dehydrogenase; Provisional; Region: PRK06701
504472013855	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
504472013856	NAD binding site [chemical binding]; other site
504472013857	metal binding site [ion binding]; metal-binding site
504472013858	active site
504472013859	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
504472013860	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472013861	catalytic loop [active]
504472013862	iron binding site [ion binding]; other site
504472013863	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
504472013864	dimanganese center [ion binding]; other site
504472013865	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
504472013866	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
504472013867	Peptidase family C25; Region: Peptidase_C25; pfam01364
504472013868	active site
504472013869	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
504472013870	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
504472013871	putative active site [active]
504472013872	catalytic site [active]
504472013873	putative metal binding site [ion binding]; other site
504472013874	oligomer interface [polypeptide binding]; other site
504472013875	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472013876	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
504472013877	active site
504472013878	metal binding site [ion binding]; metal-binding site
504472013879	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472013880	active site
504472013881	metal binding site [ion binding]; metal-binding site
504472013882	Amidohydrolase; Region: Amidohydro_5; pfam13594
504472013883	Amidohydrolase; Region: Amidohydro_4; pfam13147
504472013884	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472013885	active site
504472013886	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472013887	TM2 domain; Region: TM2; cl00984
504472013888	Haemolytic domain; Region: Haemolytic; pfam01809
504472013889	Uncharacterized conserved protein [Function unknown]; Region: COG4748
504472013890	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
504472013891	Uncharacterized conserved protein [Function unknown]; Region: COG4127
504472013892	transposase/IS protein; Provisional; Region: PRK09183
504472013893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472013894	Walker A motif; other site
504472013895	ATP binding site [chemical binding]; other site
504472013896	Walker B motif; other site
504472013897	arginine finger; other site
504472013898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472013899	Integrase core domain; Region: rve; pfam00665
504472013900	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
504472013901	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
504472013902	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472013903	non-specific DNA binding site [nucleotide binding]; other site
504472013904	salt bridge; other site
504472013905	sequence-specific DNA binding site [nucleotide binding]; other site
504472013906	tape measure domain; Region: tape_meas_nterm; TIGR02675
504472013907	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472013908	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472013909	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472013910	VirE N-terminal domain; Region: VirE_N; pfam08800
504472013911	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
504472013912	Virulence-associated protein E; Region: VirE; pfam05272
504472013913	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472013914	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
504472013915	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
504472013916	Int/Topo IB signature motif; other site
504472013917	methionine sulfoxide reductase A; Provisional; Region: PRK14054
504472013918	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
504472013919	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
504472013920	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472013921	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472013922	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472013923	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472013924	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
504472013925	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
504472013926	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
504472013927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
504472013928	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
504472013929	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
504472013930	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
504472013931	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
504472013932	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472013933	putative DNA binding site [nucleotide binding]; other site
504472013934	putative Zn2+ binding site [ion binding]; other site
504472013935	AsnC family; Region: AsnC_trans_reg; pfam01037
504472013936	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
504472013937	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472013938	active site
504472013939	NADH dehydrogenase subunit D; Validated; Region: PRK06075
504472013940	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
504472013941	ribosomal protein L33; Region: rpl33; CHL00104
504472013942	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
504472013943	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
504472013944	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
504472013945	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472013946	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
504472013947	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
504472013948	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
504472013949	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472013950	FeS/SAM binding site; other site
504472013951	TRAM domain; Region: TRAM; cl01282
504472013952	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
504472013953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
504472013954	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
504472013955	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
504472013956	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472013957	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
504472013958	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
504472013959	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
504472013960	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
504472013961	Walker A/P-loop; other site
504472013962	ATP binding site [chemical binding]; other site
504472013963	Q-loop/lid; other site
504472013964	ABC transporter signature motif; other site
504472013965	Walker B; other site
504472013966	D-loop; other site
504472013967	H-loop/switch region; other site
504472013968	Predicted membrane protein [Function unknown]; Region: COG4270
504472013969	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
504472013970	metal binding site [ion binding]; metal-binding site
504472013971	substrate binding pocket [chemical binding]; other site
504472013972	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472013973	NADH(P)-binding; Region: NAD_binding_10; pfam13460
504472013974	NAD(P) binding site [chemical binding]; other site
504472013975	active site
504472013976	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
504472013977	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472013978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472013979	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
504472013980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472013981	NAD(P) binding site [chemical binding]; other site
504472013982	active site
504472013983	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
504472013984	Sulfatase; Region: Sulfatase; cl17466
504472013985	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472013986	Sulfatase; Region: Sulfatase; cl17466
504472013987	Enterobacterial EspB protein; Region: EspB; pfam05802
504472013988	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472013989	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
504472013990	ligand-binding site [chemical binding]; other site
504472013991	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
504472013992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
504472013993	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
504472013994	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472013995	active site
504472013996	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
504472013997	dihydroorotase; Reviewed; Region: PRK09236
504472013998	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472013999	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
504472014000	active site
504472014001	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
504472014002	dimer interface [polypeptide binding]; other site
504472014003	allosteric magnesium binding site [ion binding]; other site
504472014004	active site
504472014005	aspartate-rich active site metal binding site; other site
504472014006	Schiff base residues; other site
504472014007	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472014008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472014009	active site
504472014010	phosphorylation site [posttranslational modification]
504472014011	intermolecular recognition site; other site
504472014012	dimerization interface [polypeptide binding]; other site
504472014013	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472014014	DNA binding site [nucleotide binding]
504472014015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472014016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472014017	dimer interface [polypeptide binding]; other site
504472014018	phosphorylation site [posttranslational modification]
504472014019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472014020	ATP binding site [chemical binding]; other site
504472014021	Mg2+ binding site [ion binding]; other site
504472014022	G-X-G motif; other site
504472014023	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472014024	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
504472014025	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
504472014026	Beta-lactamase; Region: Beta-lactamase; cl17358
504472014027	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472014028	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472014029	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
504472014030	nucleoside/Zn binding site; other site
504472014031	dimer interface [polypeptide binding]; other site
504472014032	catalytic motif [active]
504472014033	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
504472014034	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
504472014035	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
504472014036	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472014037	putative active site [active]
504472014038	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472014039	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472014040	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472014041	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472014042	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472014043	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
504472014044	Rubredoxin; Region: Rubredoxin; pfam00301
504472014045	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
504472014046	iron binding site [ion binding]; other site
504472014047	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
504472014048	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
504472014049	molybdopterin cofactor binding site; other site
504472014050	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
504472014051	molybdopterin cofactor binding site; other site
504472014052	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
504472014053	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472014054	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
504472014055	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
504472014056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472014057	putative substrate translocation pore; other site
504472014058	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
504472014059	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
504472014060	active site
504472014061	SAM binding site [chemical binding]; other site
504472014062	homodimer interface [polypeptide binding]; other site
504472014063	nitrite reductase subunit NirD; Provisional; Region: PRK14989
504472014064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472014065	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
504472014066	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
504472014067	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
504472014068	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
504472014069	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
504472014070	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472014071	Histidine kinase; Region: HisKA_3; pfam07730
504472014072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472014073	ATP binding site [chemical binding]; other site
504472014074	Mg2+ binding site [ion binding]; other site
504472014075	G-X-G motif; other site
504472014076	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472014077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472014078	active site
504472014079	phosphorylation site [posttranslational modification]
504472014080	intermolecular recognition site; other site
504472014081	dimerization interface [polypeptide binding]; other site
504472014082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472014083	DNA binding residues [nucleotide binding]
504472014084	dimerization interface [polypeptide binding]; other site
504472014085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
504472014086	Transposase IS200 like; Region: Y1_Tnp; cl00848
504472014087	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
504472014088	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
504472014089	NADP binding site [chemical binding]; other site
504472014090	substrate binding site [chemical binding]; other site
504472014091	active site
504472014092	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472014093	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472014094	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
504472014095	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
504472014096	active site
504472014097	trimer interface [polypeptide binding]; other site
504472014098	allosteric site; other site
504472014099	active site lid [active]
504472014100	hexamer (dimer of trimers) interface [polypeptide binding]; other site
504472014101	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
504472014102	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472014103	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472014104	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472014105	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472014106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472014107	DNA binding residues [nucleotide binding]
504472014108	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472014109	FecR protein; Region: FecR; pfam04773
504472014110	Secretin and TonB N terminus short domain; Region: STN; pfam07660
504472014111	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472014112	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472014113	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472014114	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472014115	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472014116	SusD family; Region: SusD; pfam07980
504472014117	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
504472014118	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
504472014119	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
504472014120	nudix motif; other site
504472014121	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
504472014122	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
504472014123	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472014124	catalytic loop [active]
504472014125	iron binding site [ion binding]; other site
504472014126	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472014127	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472014128	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472014129	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472014130	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472014131	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
504472014132	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
504472014133	XdhC Rossmann domain; Region: XdhC_C; pfam13478
504472014134	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
504472014135	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
504472014136	Ligand binding site; other site
504472014137	metal-binding site
504472014138	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
504472014139	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
504472014140	active site
504472014141	catalytic residues [active]
504472014142	metal binding site [ion binding]; metal-binding site
504472014143	C-N hydrolase family amidase; Provisional; Region: PRK10438
504472014144	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
504472014145	putative active site [active]
504472014146	catalytic triad [active]
504472014147	dimer interface [polypeptide binding]; other site
504472014148	multimer interface [polypeptide binding]; other site
504472014149	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
504472014150	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
504472014151	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
504472014152	Predicted transcriptional regulator [Transcription]; Region: COG1959
504472014153	Transcriptional regulator; Region: Rrf2; pfam02082
504472014154	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
504472014155	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472014156	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
504472014157	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472014158	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472014159	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
504472014160	GAF domain; Region: GAF; pfam01590
504472014161	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472014162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
504472014163	dimer interface [polypeptide binding]; other site
504472014164	phosphorylation site [posttranslational modification]
504472014165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472014166	ATP binding site [chemical binding]; other site
504472014167	Mg2+ binding site [ion binding]; other site
504472014168	G-X-G motif; other site
504472014169	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
504472014170	putative active site [active]
504472014171	Zn binding site [ion binding]; other site
504472014172	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
504472014173	Amino acid permease; Region: AA_permease_2; pfam13520
504472014174	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
504472014175	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
504472014176	Family description; Region: VCBS; pfam13517
504472014177	Family description; Region: VCBS; pfam13517
504472014178	Family description; Region: VCBS; pfam13517
504472014179	Family description; Region: VCBS; pfam13517
504472014180	Family description; Region: VCBS; pfam13517
504472014181	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472014182	FG-GAP repeat; Region: FG-GAP; pfam01839
504472014183	Family description; Region: VCBS; pfam13517
504472014184	Family description; Region: VCBS; pfam13517
504472014185	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472014186	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472014187	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
504472014188	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
504472014189	purine monophosphate binding site [chemical binding]; other site
504472014190	dimer interface [polypeptide binding]; other site
504472014191	putative catalytic residues [active]
504472014192	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
504472014193	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
504472014194	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
504472014195	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
504472014196	putative acyl-acceptor binding pocket; other site
504472014197	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
504472014198	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
504472014199	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472014200	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472014201	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
504472014202	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
504472014203	metal binding site [ion binding]; metal-binding site
504472014204	ligand binding site [chemical binding]; other site
504472014205	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
504472014206	Domain of unknown function (DUF303); Region: DUF303; pfam03629
504472014207	Domain of unknown function DUF11; Region: DUF11; cl17728
504472014208	Domain of unknown function DUF11; Region: DUF11; pfam01345
504472014209	PemK-like protein; Region: PemK; pfam02452
504472014210	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
504472014211	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
504472014212	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
504472014213	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
504472014214	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
504472014215	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
504472014216	MgtC family; Region: MgtC; pfam02308
504472014217	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
504472014218	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472014219	active site
504472014220	catalytic triad [active]
504472014221	oxyanion hole [active]
504472014222	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
504472014223	DHHW protein; Region: DHHW; pfam14286
504472014224	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
504472014225	active site
504472014226	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472014227	methionine sulfoxide reductase B; Provisional; Region: PRK00222
504472014228	SelR domain; Region: SelR; pfam01641
504472014229	DEAD-like helicases superfamily; Region: DEXDc; smart00487
504472014230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472014231	ATP binding site [chemical binding]; other site
504472014232	putative Mg++ binding site [ion binding]; other site
504472014233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472014234	nucleotide binding region [chemical binding]; other site
504472014235	ATP-binding site [chemical binding]; other site
504472014236	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
504472014237	short chain dehydrogenase; Provisional; Region: PRK06701
504472014238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472014239	NAD(P) binding site [chemical binding]; other site
504472014240	active site
504472014241	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472014242	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472014243	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472014244	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
504472014245	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
504472014246	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472014247	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
504472014248	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
504472014249	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
504472014250	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
504472014251	Glutamine amidotransferase class-I; Region: GATase; pfam00117
504472014252	glutamine binding [chemical binding]; other site
504472014253	catalytic triad [active]
504472014254	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
504472014255	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
504472014256	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
504472014257	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
504472014258	active site
504472014259	ribulose/triose binding site [chemical binding]; other site
504472014260	phosphate binding site [ion binding]; other site
504472014261	substrate (anthranilate) binding pocket [chemical binding]; other site
504472014262	product (indole) binding pocket [chemical binding]; other site
504472014263	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
504472014264	active site
504472014265	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
504472014266	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
504472014267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472014268	catalytic residue [active]
504472014269	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
504472014270	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
504472014271	substrate binding site [chemical binding]; other site
504472014272	active site
504472014273	catalytic residues [active]
504472014274	heterodimer interface [polypeptide binding]; other site
504472014275	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
504472014276	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
504472014277	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
504472014278	metal binding site [ion binding]; metal-binding site
504472014279	Membrane protein of unknown function; Region: DUF360; pfam04020
504472014280	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472014281	homotrimer interaction site [polypeptide binding]; other site
504472014282	putative active site [active]
504472014283	MG2 domain; Region: A2M_N; pfam01835
504472014284	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472014285	Alpha-2-macroglobulin family; Region: A2M; pfam00207
504472014286	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
504472014287	Cytochrome c; Region: Cytochrom_C; pfam00034
504472014288	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
504472014289	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472014290	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
504472014291	active site
504472014292	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472014293	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
504472014294	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
504472014295	Cytochrome c; Region: Cytochrom_C; pfam00034
504472014296	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
504472014297	AP (apurinic/apyrimidinic) site pocket; other site
504472014298	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472014299	DNA interaction; other site
504472014300	Metal-binding active site; metal-binding site
504472014301	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472014302	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472014303	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472014304	DNA binding residues [nucleotide binding]
504472014305	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
504472014306	serpin-like protein; Provisional; Region: PHA02660
504472014307	reactive center loop; other site
504472014308	Uncharacterized conserved protein [Function unknown]; Region: COG5276
504472014309	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
504472014310	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
504472014311	G1 box; other site
504472014312	putative GEF interaction site [polypeptide binding]; other site
504472014313	GTP/Mg2+ binding site [chemical binding]; other site
504472014314	Switch I region; other site
504472014315	G2 box; other site
504472014316	G3 box; other site
504472014317	Switch II region; other site
504472014318	G4 box; other site
504472014319	G5 box; other site
504472014320	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
504472014321	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
504472014322	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
504472014323	putative active site pocket [active]
504472014324	dimerization interface [polypeptide binding]; other site
504472014325	putative catalytic residue [active]
504472014326	Dienelactone hydrolase family; Region: DLH; pfam01738
504472014327	phosphodiesterase YaeI; Provisional; Region: PRK11340
504472014328	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
504472014329	putative active site [active]
504472014330	putative metal binding site [ion binding]; other site
504472014331	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
504472014332	putative ligand binding site [chemical binding]; other site
504472014333	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472014334	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
504472014335	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472014336	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472014337	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472014338	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
504472014339	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472014340	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472014341	recombination protein F; Reviewed; Region: recF; PRK00064
504472014342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472014343	Walker A/P-loop; other site
504472014344	ATP binding site [chemical binding]; other site
504472014345	Q-loop/lid; other site
504472014346	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
504472014347	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
504472014348	tetramer interface [polypeptide binding]; other site
504472014349	TPP-binding site [chemical binding]; other site
504472014350	heterodimer interface [polypeptide binding]; other site
504472014351	phosphorylation loop region [posttranslational modification]
504472014352	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
504472014353	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472014354	Zn binding site [ion binding]; other site
504472014355	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
504472014356	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472014357	Zn binding site [ion binding]; other site
504472014358	Predicted esterase [General function prediction only]; Region: COG0400
504472014359	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
504472014360	RNAase interaction site [polypeptide binding]; other site
504472014361	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
504472014362	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
504472014363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472014364	ATP binding site [chemical binding]; other site
504472014365	putative Mg++ binding site [ion binding]; other site
504472014366	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472014367	nucleotide binding region [chemical binding]; other site
504472014368	ATP-binding site [chemical binding]; other site
504472014369	TRCF domain; Region: TRCF; pfam03461
504472014370	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
504472014371	gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530
504472014372	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
504472014373	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
504472014374	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472014375	active site
504472014376	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
504472014377	linker region; other site
504472014378	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
504472014379	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
504472014380	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
504472014381	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472014382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472014383	S-adenosylmethionine binding site [chemical binding]; other site
504472014384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472014385	TPR motif; other site
504472014386	binding surface
504472014387	threonine synthase; Validated; Region: PRK09225
504472014388	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
504472014389	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472014390	catalytic residue [active]
504472014391	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
504472014392	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
504472014393	Glutamate binding site [chemical binding]; other site
504472014394	NAD binding site [chemical binding]; other site
504472014395	catalytic residues [active]
504472014396	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
504472014397	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
504472014398	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
504472014399	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
504472014400	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
504472014401	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
504472014402	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
504472014403	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
504472014404	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
504472014405	dimer interface [polypeptide binding]; other site
504472014406	active site
504472014407	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
504472014408	catalytic residues [active]
504472014409	substrate binding site [chemical binding]; other site
504472014410	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
504472014411	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472014412	active site
504472014413	motif I; other site
504472014414	motif II; other site
504472014415	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
504472014416	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472014417	active site
504472014418	HIGH motif; other site
504472014419	nucleotide binding site [chemical binding]; other site
504472014420	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
504472014421	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
504472014422	active site
504472014423	KMSKS motif; other site
504472014424	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
504472014425	tRNA binding surface [nucleotide binding]; other site
504472014426	anticodon binding site; other site
504472014427	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
504472014428	Protein of unknown function DUF72; Region: DUF72; pfam01904
504472014429	Protein of unknown function (DUF433); Region: DUF433; pfam04255
504472014430	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
504472014431	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
504472014432	putative active site [active]
504472014433	oxyanion strand; other site
504472014434	catalytic triad [active]
504472014435	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
504472014436	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
504472014437	catalytic residues [active]
504472014438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472014439	Coenzyme A binding pocket [chemical binding]; other site
504472014440	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
504472014441	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
504472014442	substrate binding site [chemical binding]; other site
504472014443	glutamase interaction surface [polypeptide binding]; other site
504472014444	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472014445	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
504472014446	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
504472014447	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472014448	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
504472014449	Walker A/P-loop; other site
504472014450	ATP binding site [chemical binding]; other site
504472014451	Q-loop/lid; other site
504472014452	ABC transporter signature motif; other site
504472014453	Walker B; other site
504472014454	D-loop; other site
504472014455	H-loop/switch region; other site
504472014456	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
504472014457	metal binding site 2 [ion binding]; metal-binding site
504472014458	putative DNA binding helix; other site
504472014459	metal binding site 1 [ion binding]; metal-binding site
504472014460	dimer interface [polypeptide binding]; other site
504472014461	structural Zn2+ binding site [ion binding]; other site
504472014462	MutS domain III; Region: MutS_III; pfam05192
504472014463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472014464	Walker A/P-loop; other site
504472014465	ATP binding site [chemical binding]; other site
504472014466	Q-loop/lid; other site
504472014467	ABC transporter signature motif; other site
504472014468	Walker B; other site
504472014469	D-loop; other site
504472014470	H-loop/switch region; other site
504472014471	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
504472014472	4Fe-4S binding domain; Region: Fer4; cl02805
504472014473	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
504472014474	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
504472014475	Cysteine-rich domain; Region: CCG; pfam02754
504472014476	Cysteine-rich domain; Region: CCG; pfam02754
504472014477	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
504472014478	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472014479	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472014480	DNA binding residues [nucleotide binding]
504472014481	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
504472014482	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
504472014483	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
504472014484	catalytic site [active]
504472014485	G-X2-G-X-G-K; other site
504472014486	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
504472014487	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
504472014488	active site
504472014489	(T/H)XGH motif; other site
504472014490	M28 Zn-Peptidases; Region: M28_like_6; cd08656
504472014491	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472014492	metal binding site [ion binding]; metal-binding site
504472014493	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
504472014494	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472014495	active site
504472014496	HIGH motif; other site
504472014497	nucleotide binding site [chemical binding]; other site
504472014498	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
504472014499	KMSKS motif; other site
504472014500	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
504472014501	tRNA binding surface [nucleotide binding]; other site
504472014502	anticodon binding site; other site
504472014503	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
504472014504	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472014505	substrate binding site [chemical binding]; other site
504472014506	ATP binding site [chemical binding]; other site
504472014507	Ferritin-like domain; Region: Ferritin_2; pfam13668
504472014508	Ferritin-like domain; Region: Ferritin_2; pfam13668
504472014509	short chain dehydrogenase; Provisional; Region: PRK06172
504472014510	classical (c) SDRs; Region: SDR_c; cd05233
504472014511	NAD(P) binding site [chemical binding]; other site
504472014512	active site
504472014513	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
504472014514	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
504472014515	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472014516	Coenzyme A binding pocket [chemical binding]; other site
504472014517	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
504472014518	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
504472014519	NAD(P) binding site [chemical binding]; other site
504472014520	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
504472014521	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
504472014522	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472014523	catalytic residue [active]
504472014524	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
504472014525	AAA domain; Region: AAA_26; pfam13500
504472014526	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
504472014527	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
504472014528	homodimer interface [polypeptide binding]; other site
504472014529	substrate-cofactor binding pocket; other site
504472014530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472014531	catalytic residue [active]
504472014532	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
504472014533	Beta-lactamase; Region: Beta-lactamase; pfam00144
504472014534	Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527
504472014535	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
504472014536	nucleotide binding site [chemical binding]; other site
504472014537	substrate binding site [chemical binding]; other site
504472014538	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
504472014539	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
504472014540	TPP-binding site; other site
504472014541	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
504472014542	PYR/PP interface [polypeptide binding]; other site
504472014543	dimer interface [polypeptide binding]; other site
504472014544	TPP binding site [chemical binding]; other site
504472014545	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
504472014546	Rhomboid family; Region: Rhomboid; cl11446
504472014547	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
504472014548	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
504472014549	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
504472014550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472014551	ATP binding site [chemical binding]; other site
504472014552	Mg2+ binding site [ion binding]; other site
504472014553	G-X-G motif; other site
504472014554	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
504472014555	ATP binding site [chemical binding]; other site
504472014556	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
504472014557	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
504472014558	elongation factor G; Reviewed; Region: PRK12739
504472014559	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
504472014560	G1 box; other site
504472014561	putative GEF interaction site [polypeptide binding]; other site
504472014562	GTP/Mg2+ binding site [chemical binding]; other site
504472014563	Switch I region; other site
504472014564	G2 box; other site
504472014565	G3 box; other site
504472014566	Switch II region; other site
504472014567	G4 box; other site
504472014568	G5 box; other site
504472014569	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
504472014570	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
504472014571	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
504472014572	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472014573	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472014574	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472014575	Walker A/P-loop; other site
504472014576	ATP binding site [chemical binding]; other site
504472014577	Q-loop/lid; other site
504472014578	ABC transporter signature motif; other site
504472014579	Walker B; other site
504472014580	D-loop; other site
504472014581	H-loop/switch region; other site
504472014582	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
504472014583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
504472014584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472014585	Integrase core domain; Region: rve; pfam00665
504472014586	transposase/IS protein; Provisional; Region: PRK09183
504472014587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472014588	Walker A motif; other site
504472014589	ATP binding site [chemical binding]; other site
504472014590	Walker B motif; other site
504472014591	arginine finger; other site
504472014592	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472014593	binding surface
504472014594	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472014595	TPR motif; other site
504472014596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472014597	binding surface
504472014598	Tetratricopeptide repeat; Region: TPR_16; pfam13432
504472014599	TPR motif; other site
504472014600	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
504472014601	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472014602	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472014603	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472014604	non-specific DNA binding site [nucleotide binding]; other site
504472014605	salt bridge; other site
504472014606	sequence-specific DNA binding site [nucleotide binding]; other site
504472014607	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
504472014608	Catalytic site [active]
504472014609	DNA polymerase IV; Reviewed; Region: PRK03103
504472014610	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
504472014611	active site
504472014612	DNA binding site [nucleotide binding]
504472014613	Pirin; Region: Pirin; pfam02678
504472014614	Pirin-related protein [General function prediction only]; Region: COG1741
504472014615	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
504472014616	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
504472014617	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_4; cd08976
504472014618	putative DNA binding site [nucleotide binding]; other site
504472014619	catalytic residue [active]
504472014620	putative H2TH interface [polypeptide binding]; other site
504472014621	putative catalytic residues [active]
504472014622	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
504472014623	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
504472014624	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
504472014625	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
504472014626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472014627	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
504472014628	Walker A/P-loop; other site
504472014629	ATP binding site [chemical binding]; other site
504472014630	Q-loop/lid; other site
504472014631	ABC transporter signature motif; other site
504472014632	Walker B; other site
504472014633	D-loop; other site
504472014634	H-loop/switch region; other site
504472014635	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
504472014636	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
504472014637	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
504472014638	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
504472014639	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472014640	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472014641	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472014642	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472014643	ligand binding site [chemical binding]; other site
504472014644	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
504472014645	Part of AAA domain; Region: AAA_19; pfam13245
504472014646	Family description; Region: UvrD_C_2; pfam13538
504472014647	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472014648	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472014649	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472014650	DNA binding residues [nucleotide binding]
504472014651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
504472014652	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
504472014653	triosephosphate isomerase; Provisional; Region: PRK14567
504472014654	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
504472014655	substrate binding site [chemical binding]; other site
504472014656	dimer interface [polypeptide binding]; other site
504472014657	catalytic triad [active]
504472014658	Aspartyl protease; Region: Asp_protease_2; pfam13650
504472014659	inhibitor binding site; inhibition site
504472014660	catalytic motif [active]
504472014661	Catalytic residue [active]
504472014662	Active site flap [active]
504472014663	Aspartyl protease; Region: Asp_protease_2; pfam13650
504472014664	inhibitor binding site; inhibition site
504472014665	catalytic motif [active]
504472014666	Catalytic residue [active]
504472014667	Active site flap [active]
504472014668	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
504472014669	protein binding site [polypeptide binding]; other site
504472014670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472014671	dimer interface [polypeptide binding]; other site
504472014672	phosphorylation site [posttranslational modification]
504472014673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472014674	ATP binding site [chemical binding]; other site
504472014675	Mg2+ binding site [ion binding]; other site
504472014676	G-X-G motif; other site
504472014677	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472014678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472014679	active site
504472014680	phosphorylation site [posttranslational modification]
504472014681	intermolecular recognition site; other site
504472014682	dimerization interface [polypeptide binding]; other site
504472014683	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472014684	DNA binding site [nucleotide binding]
504472014685	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
504472014686	Domain of unknown function DUF20; Region: UPF0118; pfam01594
504472014687	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
504472014688	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
504472014689	catalytic triad [active]
504472014690	conserved cis-peptide bond; other site
504472014691	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
504472014692	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
504472014693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472014694	S-adenosylmethionine binding site [chemical binding]; other site
504472014695	CAAX protease self-immunity; Region: Abi; pfam02517
504472014696	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472014697	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472014698	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472014699	Two component regulator propeller; Region: Reg_prop; pfam07494
504472014700	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
504472014701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472014702	PAS fold; Region: PAS_3; pfam08447
504472014703	putative active site [active]
504472014704	heme pocket [chemical binding]; other site
504472014705	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472014706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472014707	dimer interface [polypeptide binding]; other site
504472014708	phosphorylation site [posttranslational modification]
504472014709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472014710	ATP binding site [chemical binding]; other site
504472014711	Mg2+ binding site [ion binding]; other site
504472014712	G-X-G motif; other site
504472014713	Abhydrolase family; Region: Abhydrolase_7; pfam12715
504472014714	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472014715	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472014716	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472014717	AAA domain; Region: AAA_14; pfam13173
504472014718	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
504472014719	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
504472014720	Uncharacterized conserved protein [Function unknown]; Region: COG4279
504472014721	SNF2 Helicase protein; Region: DUF3670; pfam12419
504472014722	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
504472014723	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472014724	ATP binding site [chemical binding]; other site
504472014725	putative Mg++ binding site [ion binding]; other site
504472014726	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472014727	nucleotide binding region [chemical binding]; other site
504472014728	ATP-binding site [chemical binding]; other site
504472014729	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
504472014730	Predicted dehydrogenase [General function prediction only]; Region: COG0579
504472014731	hydroxyglutarate oxidase; Provisional; Region: PRK11728
504472014732	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
504472014733	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
504472014734	dimerization interface [polypeptide binding]; other site
504472014735	DPS ferroxidase diiron center [ion binding]; other site
504472014736	ion pore; other site
504472014737	seryl-tRNA synthetase; Provisional; Region: PRK05431
504472014738	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
504472014739	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
504472014740	dimer interface [polypeptide binding]; other site
504472014741	active site
504472014742	motif 1; other site
504472014743	motif 2; other site
504472014744	motif 3; other site
504472014745	aspartate kinase III; Validated; Region: PRK09084
504472014746	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
504472014747	putative catalytic residues [active]
504472014748	nucleotide binding site [chemical binding]; other site
504472014749	aspartate binding site [chemical binding]; other site
504472014750	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
504472014751	dimer interface [polypeptide binding]; other site
504472014752	allosteric regulatory binding pocket; other site
504472014753	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
504472014754	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
504472014755	homopentamer interface [polypeptide binding]; other site
504472014756	active site
504472014757	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
504472014758	Tetratricopeptide repeat; Region: TPR_6; pfam13174
504472014759	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472014760	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472014761	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472014762	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
504472014763	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
504472014764	homodimer interface [polypeptide binding]; other site
504472014765	substrate-cofactor binding pocket; other site
504472014766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472014767	catalytic residue [active]
504472014768	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
504472014769	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
504472014770	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
504472014771	putative active site [active]
504472014772	putative catalytic site [active]
504472014773	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
504472014774	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
504472014775	active site
504472014776	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472014777	geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169
504472014778	PcrB family; Region: PcrB; pfam01884
504472014779	phosphate binding site [ion binding]; other site
504472014780	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
504472014781	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
504472014782	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
504472014783	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
504472014784	NAD(P) binding site [chemical binding]; other site
504472014785	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
504472014786	choline dehydrogenase; Validated; Region: PRK02106
504472014787	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472014788	GH3 auxin-responsive promoter; Region: GH3; pfam03321
504472014789	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
504472014790	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
504472014791	active site
504472014792	catalytic site [active]
504472014793	Family description; Region: VCBS; pfam13517
504472014794	Family description; Region: VCBS; pfam13517
504472014795	Family description; Region: VCBS; pfam13517
504472014796	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
504472014797	Family description; Region: VCBS; pfam13517
504472014798	Family description; Region: VCBS; pfam13517
504472014799	Family description; Region: VCBS; pfam13517
504472014800	Family description; Region: VCBS; pfam13517
504472014801	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472014802	SusD family; Region: SusD; pfam07980
504472014803	Secretin and TonB N terminus short domain; Region: STN; smart00965
504472014804	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472014805	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472014806	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472014807	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472014808	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472014809	FecR protein; Region: FecR; pfam04773
504472014810	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472014811	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472014812	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
504472014813	DNA binding residues [nucleotide binding]
504472014814	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
504472014815	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
504472014816	active site
504472014817	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472014818	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
504472014819	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
504472014820	SmpB-tmRNA interface; other site
504472014821	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
504472014822	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
504472014823	active site
504472014824	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
504472014825	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
504472014826	RNA binding site [nucleotide binding]; other site
504472014827	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
504472014828	RNA binding site [nucleotide binding]; other site
504472014829	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
504472014830	RNA binding site [nucleotide binding]; other site
504472014831	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
504472014832	RNA binding site [nucleotide binding]; other site
504472014833	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
504472014834	RNA binding site [nucleotide binding]; other site
504472014835	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
504472014836	Cytochrome c; Region: Cytochrom_C; pfam00034
504472014837	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
504472014838	heme-binding residues [chemical binding]; other site
504472014839	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
504472014840	molybdopterin cofactor binding site; other site
504472014841	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
504472014842	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
504472014843	4Fe-4S binding domain; Region: Fer4_2; pfam12797
504472014844	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
504472014845	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
504472014846	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
504472014847	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
504472014848	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
504472014849	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
504472014850	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
504472014851	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
504472014852	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
504472014853	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
504472014854	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
504472014855	protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473
504472014856	UbiA prenyltransferase family; Region: UbiA; pfam01040
504472014857	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
504472014858	Subunit I/III interface [polypeptide binding]; other site
504472014859	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
504472014860	Subunit I/III interface [polypeptide binding]; other site
504472014861	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
504472014862	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
504472014863	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
504472014864	Cu(I) binding site [ion binding]; other site
504472014865	Protein of unknown function (DUF420); Region: DUF420; pfam04238
504472014866	Protein of unknown function (DUF983); Region: DUF983; cl02211
504472014867	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472014868	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472014869	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472014870	DNA binding residues [nucleotide binding]
504472014871	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472014872	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
504472014873	putative NAD(P) binding site [chemical binding]; other site
504472014874	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
504472014875	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472014876	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472014877	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
504472014878	putative active site [active]
504472014879	putative metal binding site [ion binding]; other site
504472014880	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
504472014881	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
504472014882	putative trimer interface [polypeptide binding]; other site
504472014883	putative CoA binding site [chemical binding]; other site
504472014884	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
504472014885	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
504472014886	NADP binding site [chemical binding]; other site
504472014887	active site
504472014888	putative substrate binding site [chemical binding]; other site
504472014889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
504472014890	TPR repeat; Region: TPR_11; pfam13414
504472014891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472014892	TPR motif; other site
504472014893	binding surface
504472014894	helicase 45; Provisional; Region: PTZ00424
504472014895	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
504472014896	ATP binding site [chemical binding]; other site
504472014897	Mg++ binding site [ion binding]; other site
504472014898	motif III; other site
504472014899	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472014900	nucleotide binding region [chemical binding]; other site
504472014901	ATP-binding site [chemical binding]; other site
504472014902	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
504472014903	Phosphotransferase enzyme family; Region: APH; pfam01636
504472014904	active site
504472014905	ATP binding site [chemical binding]; other site
504472014906	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
504472014907	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
504472014908	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
504472014909	MPT binding site; other site
504472014910	trimer interface [polypeptide binding]; other site
504472014911	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472014912	Glycogen synthase; Region: Glycogen_syn; pfam05693
504472014913	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
504472014914	active site
504472014915	dimer interface [polypeptide binding]; other site
504472014916	catalytic nucleophile [active]
504472014917	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
504472014918	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
504472014919	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
504472014920	putative active site [active]
504472014921	putative substrate binding site [chemical binding]; other site
504472014922	putative cosubstrate binding site; other site
504472014923	catalytic site [active]
504472014924	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
504472014925	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
504472014926	beta-carotene hydroxylase; Region: PLN02601
504472014927	Divergent AAA domain; Region: AAA_4; pfam04326
504472014928	OPT oligopeptide transporter protein; Region: OPT; cl14607
504472014929	putative oligopeptide transporter, OPT family; Region: TIGR00733
504472014930	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
504472014931	homodimer interface [polypeptide binding]; other site
504472014932	homotetramer interface [polypeptide binding]; other site
504472014933	active site pocket [active]
504472014934	cleavage site
504472014935	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
504472014936	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
504472014937	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
504472014938	HSP70 interaction site [polypeptide binding]; other site
504472014939	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
504472014940	dimer interface [polypeptide binding]; other site
504472014941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
504472014942	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
504472014943	putative active site [active]
504472014944	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
504472014945	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472014946	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472014947	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472014948	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472014949	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472014950	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
504472014951	protein binding site [polypeptide binding]; other site
504472014952	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
504472014953	Domain interface; other site
504472014954	Peptide binding site; other site
504472014955	Active site tetrad [active]
504472014956	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472014957	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472014958	ligand binding site [chemical binding]; other site
504472014959	flexible hinge region; other site
504472014960	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
504472014961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472014962	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472014963	NAD(P) binding site [chemical binding]; other site
504472014964	active site
504472014965	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
504472014966	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472014967	putative metal binding site [ion binding]; other site
504472014968	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472014969	Uncharacterized conserved protein [Function unknown]; Region: COG3391
504472014970	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472014971	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472014972	TIR domain; Region: TIR_2; pfam13676
504472014973	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
504472014974	nucleotide binding site [chemical binding]; other site
504472014975	putative NEF/HSP70 interaction site [polypeptide binding]; other site
504472014976	SBD interface [polypeptide binding]; other site
504472014977	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472014978	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
504472014979	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
504472014980	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
504472014981	ligand binding site [chemical binding]; other site
504472014982	lipoprotein signal peptidase; Provisional; Region: PRK14788
504472014983	lipoprotein signal peptidase; Provisional; Region: PRK14787
504472014984	Proline dehydrogenase; Region: Pro_dh; cl03282
504472014985	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
504472014986	Chorismate mutase type II; Region: CM_2; smart00830
504472014987	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
504472014988	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472014989	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472014990	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472014991	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
504472014992	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472014993	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472014994	Peptidase S46; Region: Peptidase_S46; pfam10459
504472014995	Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949
504472014996	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
504472014997	DinB superfamily; Region: DinB_2; pfam12867
504472014998	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472014999	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472015000	Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527
504472015001	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472015002	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
504472015003	dimer interface [polypeptide binding]; other site
504472015004	ADP-ribose binding site [chemical binding]; other site
504472015005	active site
504472015006	nudix motif; other site
504472015007	metal binding site [ion binding]; metal-binding site
504472015008	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
504472015009	nucleoside/Zn binding site; other site
504472015010	dimer interface [polypeptide binding]; other site
504472015011	catalytic motif [active]
504472015012	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
504472015013	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
504472015014	substrate binding pocket [chemical binding]; other site
504472015015	chain length determination region; other site
504472015016	substrate-Mg2+ binding site; other site
504472015017	catalytic residues [active]
504472015018	aspartate-rich region 1; other site
504472015019	active site lid residues [active]
504472015020	aspartate-rich region 2; other site
504472015021	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
504472015022	LytTr DNA-binding domain; Region: LytTR; smart00850
504472015023	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
504472015024	active site
504472015025	catalytic triad [active]
504472015026	oxyanion hole [active]
504472015027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472015028	putative substrate translocation pore; other site
504472015029	putative oxidoreductase; Provisional; Region: PRK11579
504472015030	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472015031	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472015032	peptide chain release factor 2; Validated; Region: prfB; PRK00578
504472015033	This domain is found in peptide chain release factors; Region: PCRF; smart00937
504472015034	RF-1 domain; Region: RF-1; pfam00472
504472015035	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
504472015036	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472015037	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472015038	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
504472015039	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472015040	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
504472015041	Ligand binding site; other site
504472015042	DXD motif; other site
504472015043	Putative Catalytic site; other site
504472015044	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
504472015045	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472015046	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
504472015047	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472015048	N-terminal plug; other site
504472015049	ligand-binding site [chemical binding]; other site
504472015050	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
504472015051	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
504472015052	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
504472015053	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
504472015054	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
504472015055	AAA domain; Region: AAA_11; pfam13086
504472015056	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
504472015057	G1 box; other site
504472015058	GTP/Mg2+ binding site [chemical binding]; other site
504472015059	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
504472015060	AAA domain; Region: AAA_12; pfam13087
504472015061	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
504472015062	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
504472015063	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
504472015064	catalytic site [active]
504472015065	subunit interface [polypeptide binding]; other site
504472015066	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
504472015067	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
504472015068	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
504472015069	alphaNTD homodimer interface [polypeptide binding]; other site
504472015070	alphaNTD - beta interaction site [polypeptide binding]; other site
504472015071	alphaNTD - beta' interaction site [polypeptide binding]; other site
504472015072	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
504472015073	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
504472015074	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
504472015075	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
504472015076	RNA binding surface [nucleotide binding]; other site
504472015077	30S ribosomal protein S11; Validated; Region: PRK05309
504472015078	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
504472015079	30S ribosomal protein S13; Region: bact_S13; TIGR03631
504472015080	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
504472015081	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
504472015082	rRNA binding site [nucleotide binding]; other site
504472015083	predicted 30S ribosome binding site; other site
504472015084	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
504472015085	active site
504472015086	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
504472015087	SecY translocase; Region: SecY; pfam00344
504472015088	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
504472015089	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
504472015090	23S rRNA binding site [nucleotide binding]; other site
504472015091	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
504472015092	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
504472015093	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
504472015094	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
504472015095	23S rRNA interface [nucleotide binding]; other site
504472015096	L21e interface [polypeptide binding]; other site
504472015097	5S rRNA interface [nucleotide binding]; other site
504472015098	L27 interface [polypeptide binding]; other site
504472015099	L5 interface [polypeptide binding]; other site
504472015100	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
504472015101	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
504472015102	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
504472015103	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
504472015104	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
504472015105	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
504472015106	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
504472015107	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
504472015108	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
504472015109	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
504472015110	RNA binding site [nucleotide binding]; other site
504472015111	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
504472015112	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
504472015113	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
504472015114	putative translocon interaction site; other site
504472015115	23S rRNA interface [nucleotide binding]; other site
504472015116	signal recognition particle (SRP54) interaction site; other site
504472015117	L23 interface [polypeptide binding]; other site
504472015118	trigger factor interaction site; other site
504472015119	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
504472015120	23S rRNA interface [nucleotide binding]; other site
504472015121	5S rRNA interface [nucleotide binding]; other site
504472015122	putative antibiotic binding site [chemical binding]; other site
504472015123	L25 interface [polypeptide binding]; other site
504472015124	L27 interface [polypeptide binding]; other site
504472015125	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
504472015126	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
504472015127	G-X-X-G motif; other site
504472015128	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
504472015129	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
504472015130	putative translocon binding site; other site
504472015131	protein-rRNA interface [nucleotide binding]; other site
504472015132	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
504472015133	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
504472015134	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
504472015135	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
504472015136	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
504472015137	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
504472015138	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
504472015139	Transposase IS200 like; Region: Y1_Tnp; pfam01797
504472015140	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472015141	tropinone reductase; Provisional; Region: PRK09242
504472015142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472015143	NAD(P) binding site [chemical binding]; other site
504472015144	active site
504472015145	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472015146	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472015147	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472015148	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472015149	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472015150	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472015151	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472015152	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
504472015153	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
504472015154	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
504472015155	Ligand Binding Site [chemical binding]; other site
504472015156	Family description; Region: VCBS; pfam13517
504472015157	Family description; Region: VCBS; pfam13517
504472015158	Family description; Region: VCBS; pfam13517
504472015159	Family description; Region: VCBS; pfam13517
504472015160	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472015161	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472015162	SusD family; Region: SusD; pfam07980
504472015163	Secretin and TonB N terminus short domain; Region: STN; pfam07660
504472015164	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472015165	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472015166	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472015167	FecR protein; Region: FecR; pfam04773
504472015168	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472015169	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472015170	DNA binding residues [nucleotide binding]
504472015171	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
504472015172	active site
504472015173	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
504472015174	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
504472015175	putative ion selectivity filter; other site
504472015176	putative pore gating glutamate residue; other site
504472015177	putative H+/Cl- coupling transport residue; other site
504472015178	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
504472015179	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472015180	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472015181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472015182	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472015183	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472015184	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472015185	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472015186	HEAT repeats; Region: HEAT_2; pfam13646
504472015187	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
504472015188	Cytochrome c; Region: Cytochrom_C; pfam00034
504472015189	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472015190	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
504472015191	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
504472015192	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
504472015193	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472015194	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472015195	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472015196	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
504472015197	putative active site [active]
504472015198	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
504472015199	classical (c) SDRs; Region: SDR_c; cd05233
504472015200	NAD(P) binding site [chemical binding]; other site
504472015201	active site
504472015202	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472015203	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472015204	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
504472015205	substrate binding site [chemical binding]; other site
504472015206	THF binding site; other site
504472015207	zinc-binding site [ion binding]; other site
504472015208	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
504472015209	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
504472015210	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
504472015211	dimer interface [polypeptide binding]; other site
504472015212	substrate binding site [chemical binding]; other site
504472015213	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
504472015214	metal binding site [ion binding]; metal-binding site
504472015215	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
504472015216	Zn binding site [ion binding]; other site
504472015217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472015218	AAA domain; Region: AAA_21; pfam13304
504472015219	Walker A/P-loop; other site
504472015220	ATP binding site [chemical binding]; other site
504472015221	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
504472015222	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
504472015223	dimer interface [polypeptide binding]; other site
504472015224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472015225	catalytic residue [active]
504472015226	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
504472015227	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
504472015228	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
504472015229	GTPase RsgA; Reviewed; Region: PRK00098
504472015230	RNA binding site [nucleotide binding]; other site
504472015231	homodimer interface [polypeptide binding]; other site
504472015232	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
504472015233	GTPase/Zn-binding domain interface [polypeptide binding]; other site
504472015234	GTP/Mg2+ binding site [chemical binding]; other site
504472015235	G4 box; other site
504472015236	G5 box; other site
504472015237	G1 box; other site
504472015238	Switch I region; other site
504472015239	G2 box; other site
504472015240	G3 box; other site
504472015241	Switch II region; other site
504472015242	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
504472015243	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
504472015244	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
504472015245	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
504472015246	active site
504472015247	DivIVA protein; Region: DivIVA; pfam05103
504472015248	DivIVA domain; Region: DivI1A_domain; TIGR03544
504472015249	FOG: WD40 repeat [General function prediction only]; Region: COG2319
504472015250	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
504472015251	structural tetrad; other site
504472015252	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
504472015253	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
504472015254	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
504472015255	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
504472015256	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
504472015257	NAD binding site [chemical binding]; other site
504472015258	homodimer interface [polypeptide binding]; other site
504472015259	active site
504472015260	substrate binding site [chemical binding]; other site
504472015261	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
504472015262	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
504472015263	NAD binding site [chemical binding]; other site
504472015264	substrate binding site [chemical binding]; other site
504472015265	homodimer interface [polypeptide binding]; other site
504472015266	active site
504472015267	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
504472015268	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
504472015269	substrate binding site; other site
504472015270	tetramer interface; other site
504472015271	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
504472015272	Histidine kinase; Region: HisKA_3; pfam07730
504472015273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472015274	ATP binding site [chemical binding]; other site
504472015275	Mg2+ binding site [ion binding]; other site
504472015276	G-X-G motif; other site
504472015277	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472015278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472015279	active site
504472015280	phosphorylation site [posttranslational modification]
504472015281	intermolecular recognition site; other site
504472015282	dimerization interface [polypeptide binding]; other site
504472015283	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472015284	DNA binding residues [nucleotide binding]
504472015285	dimerization interface [polypeptide binding]; other site
504472015286	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
504472015287	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
504472015288	putative NAD(P) binding site [chemical binding]; other site
504472015289	putative active site [active]
504472015290	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
504472015291	Repair protein; Region: Repair_PSII; pfam04536
504472015292	Repair protein; Region: Repair_PSII; pfam04536
504472015293	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
504472015294	putative ligand binding site [chemical binding]; other site
504472015295	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
504472015296	dimer interface [polypeptide binding]; other site
504472015297	active site
504472015298	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472015299	active site
504472015300	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
504472015301	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
504472015302	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
504472015303	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
504472015304	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
504472015305	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
504472015306	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
504472015307	quinone interaction residues [chemical binding]; other site
504472015308	active site
504472015309	catalytic residues [active]
504472015310	FMN binding site [chemical binding]; other site
504472015311	substrate binding site [chemical binding]; other site
504472015312	cysteine synthase B; Region: cysM; TIGR01138
504472015313	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
504472015314	dimer interface [polypeptide binding]; other site
504472015315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472015316	catalytic residue [active]
504472015317	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
504472015318	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
504472015319	acyl-activating enzyme (AAE) consensus motif; other site
504472015320	putative AMP binding site [chemical binding]; other site
504472015321	putative active site [active]
504472015322	putative CoA binding site [chemical binding]; other site
504472015323	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
504472015324	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
504472015325	putative molybdopterin cofactor binding site [chemical binding]; other site
504472015326	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
504472015327	putative molybdopterin cofactor binding site; other site
504472015328	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
504472015329	Divergent AAA domain; Region: AAA_4; pfam04326
504472015330	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472015331	PemK-like protein; Region: PemK; pfam02452
504472015332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472015333	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472015334	active site
504472015335	DNA binding site [nucleotide binding]
504472015336	Int/Topo IB signature motif; other site
504472015337	ribonuclease R; Region: RNase_R; TIGR02063
504472015338	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
504472015339	RNB domain; Region: RNB; pfam00773
504472015340	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
504472015341	RNA binding site [nucleotide binding]; other site
504472015342	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
504472015343	active site
504472015344	catalytic site [active]
504472015345	substrate binding site [chemical binding]; other site
504472015346	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
504472015347	hypothetical protein; Reviewed; Region: PRK12497
504472015348	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472015349	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
504472015350	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
504472015351	Catalytic dyad [active]
504472015352	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
504472015353	catalytic motif [active]
504472015354	Catalytic residue [active]
504472015355	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472015356	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
504472015357	substrate binding site [chemical binding]; other site
504472015358	ATP binding site [chemical binding]; other site
504472015359	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
504472015360	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
504472015361	inhibitor-cofactor binding pocket; inhibition site
504472015362	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472015363	catalytic residue [active]
504472015364	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472015365	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
504472015366	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472015367	S-adenosylmethionine binding site [chemical binding]; other site
504472015368	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
504472015369	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472015370	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
504472015371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472015372	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
504472015373	NAD(P) binding site [chemical binding]; other site
504472015374	active site
504472015375	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
504472015376	putative active site [active]
504472015377	putative metal binding site [ion binding]; other site
504472015378	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
504472015379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472015380	Walker A/P-loop; other site
504472015381	ATP binding site [chemical binding]; other site
504472015382	Q-loop/lid; other site
504472015383	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472015384	ABC transporter signature motif; other site
504472015385	Walker B; other site
504472015386	D-loop; other site
504472015387	H-loop/switch region; other site
504472015388	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
504472015389	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
504472015390	active site
504472015391	metal binding site [ion binding]; metal-binding site
504472015392	DNA binding site [nucleotide binding]
504472015393	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
504472015394	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
504472015395	active site
504472015396	catalytic residues [active]
504472015397	metal binding site [ion binding]; metal-binding site
504472015398	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
504472015399	tartrate dehydrogenase; Region: TTC; TIGR02089
504472015400	Methyltransferase domain; Region: Methyltransf_23; pfam13489
504472015401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472015402	S-adenosylmethionine binding site [chemical binding]; other site
504472015403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
504472015404	2-isopropylmalate synthase; Validated; Region: PRK00915
504472015405	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
504472015406	active site
504472015407	catalytic residues [active]
504472015408	metal binding site [ion binding]; metal-binding site
504472015409	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
504472015410	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
504472015411	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
504472015412	substrate binding site [chemical binding]; other site
504472015413	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
504472015414	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
504472015415	substrate binding site [chemical binding]; other site
504472015416	ligand binding site [chemical binding]; other site
504472015417	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
504472015418	GIY-YIG motif/motif A; other site
504472015419	putative active site [active]
504472015420	putative metal binding site [ion binding]; other site
504472015421	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
504472015422	DoxX-like family; Region: DoxX_2; pfam13564
504472015423	Predicted transcriptional regulators [Transcription]; Region: COG1733
504472015424	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472015425	dimerization interface [polypeptide binding]; other site
504472015426	putative DNA binding site [nucleotide binding]; other site
504472015427	putative Zn2+ binding site [ion binding]; other site
504472015428	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472015429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472015430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
504472015431	Protein of unknown function (DUF433); Region: DUF433; pfam04255
504472015432	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
504472015433	tetramer interface [polypeptide binding]; other site
504472015434	threonine dehydratase; Validated; Region: PRK08639
504472015435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472015436	catalytic residue [active]
504472015437	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
504472015438	putative Ile/Val binding site [chemical binding]; other site
504472015439	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
504472015440	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
504472015441	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
504472015442	acetolactate synthase, small subunit; Region: acolac_sm; TIGR00119
504472015443	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
504472015444	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
504472015445	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
504472015446	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
504472015447	PYR/PP interface [polypeptide binding]; other site
504472015448	dimer interface [polypeptide binding]; other site
504472015449	TPP binding site [chemical binding]; other site
504472015450	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
504472015451	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
504472015452	TPP-binding site [chemical binding]; other site
504472015453	dimer interface [polypeptide binding]; other site
504472015454	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
504472015455	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
504472015456	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
504472015457	putative active site [active]
504472015458	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
504472015459	dimerization interface [polypeptide binding]; other site
504472015460	putative active cleft [active]
504472015461	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
504472015462	Found in ATP-dependent protease La (LON); Region: LON; smart00464
504472015463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472015464	Walker A motif; other site
504472015465	ATP binding site [chemical binding]; other site
504472015466	Walker B motif; other site
504472015467	arginine finger; other site
504472015468	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
504472015469	RIP metalloprotease RseP; Region: TIGR00054
504472015470	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
504472015471	active site
504472015472	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
504472015473	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
504472015474	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
504472015475	putative substrate binding region [chemical binding]; other site
504472015476	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
504472015477	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
504472015478	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
504472015479	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
504472015480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472015481	Walker A/P-loop; other site
504472015482	ATP binding site [chemical binding]; other site
504472015483	AAA domain; Region: AAA_21; pfam13304
504472015484	GH3 auxin-responsive promoter; Region: GH3; pfam03321
504472015485	rod shape-determining protein MreB; Provisional; Region: PRK13927
504472015486	MreB and similar proteins; Region: MreB_like; cd10225
504472015487	nucleotide binding site [chemical binding]; other site
504472015488	Mg binding site [ion binding]; other site
504472015489	putative protofilament interaction site [polypeptide binding]; other site
504472015490	RodZ interaction site [polypeptide binding]; other site
504472015491	rod shape-determining protein MreC; Provisional; Region: PRK13922
504472015492	rod shape-determining protein MreC; Region: MreC; pfam04085
504472015493	methionine gamma-lyase; Validated; Region: PRK07049
504472015494	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
504472015495	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472015496	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
504472015497	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
504472015498	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
504472015499	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
504472015500	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
504472015501	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
504472015502	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
504472015503	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
504472015504	Mechanosensitive ion channel; Region: MS_channel; pfam00924
504472015505	glycerol kinase; Provisional; Region: glpK; PRK00047
504472015506	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
504472015507	N- and C-terminal domain interface [polypeptide binding]; other site
504472015508	active site
504472015509	MgATP binding site [chemical binding]; other site
504472015510	catalytic site [active]
504472015511	metal binding site [ion binding]; metal-binding site
504472015512	putative homotetramer interface [polypeptide binding]; other site
504472015513	glycerol binding site [chemical binding]; other site
504472015514	homodimer interface [polypeptide binding]; other site
504472015515	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
504472015516	amphipathic channel; other site
504472015517	Asn-Pro-Ala signature motifs; other site
504472015518	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
504472015519	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
504472015520	NADP binding site [chemical binding]; other site
504472015521	dimer interface [polypeptide binding]; other site
504472015522	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
504472015523	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
504472015524	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472015525	active site
504472015526	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
504472015527	[2Fe-2S] cluster binding site [ion binding]; other site
504472015528	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
504472015529	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472015530	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472015531	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
504472015532	active site
504472015533	catalytic site [active]
504472015534	substrate binding site [chemical binding]; other site
504472015535	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
504472015536	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
504472015537	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
504472015538	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472015539	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
504472015540	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472015541	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
504472015542	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472015543	Predicted membrane protein [Function unknown]; Region: COG2246
504472015544	GtrA-like protein; Region: GtrA; pfam04138
504472015545	SprT homologues; Region: SprT; cl01182
504472015546	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
504472015547	active site
504472015548	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472015549	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
504472015550	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
504472015551	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
504472015552	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
504472015553	hypothetical protein; Provisional; Region: PRK08201
504472015554	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
504472015555	metal binding site [ion binding]; metal-binding site
504472015556	putative dimer interface [polypeptide binding]; other site
504472015557	TolA protein; Region: tolA_full; TIGR02794
504472015558	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
504472015559	adenylosuccinate lyase; Provisional; Region: PRK09285
504472015560	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
504472015561	tetramer interface [polypeptide binding]; other site
504472015562	active site
504472015563	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
504472015564	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
504472015565	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
504472015566	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472015567	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472015568	catalytic residues [active]
504472015569	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
504472015570	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
504472015571	GatB domain; Region: GatB_Yqey; smart00845
504472015572	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
504472015573	active site lid residues [active]
504472015574	substrate binding pocket [chemical binding]; other site
504472015575	catalytic residues [active]
504472015576	substrate-Mg2+ binding site; other site
504472015577	aspartate-rich region 1; other site
504472015578	aspartate-rich region 2; other site
504472015579	phytoene desaturase; Region: crtI_fam; TIGR02734
504472015580	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472015581	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472015582	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472015583	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472015584	DNA binding residues [nucleotide binding]
504472015585	KpsF/GutQ family protein; Region: kpsF; TIGR00393
504472015586	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
504472015587	putative active site [active]
504472015588	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
504472015589	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
504472015590	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472015591	ATP binding site [chemical binding]; other site
504472015592	putative Mg++ binding site [ion binding]; other site
504472015593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472015594	nucleotide binding region [chemical binding]; other site
504472015595	ATP-binding site [chemical binding]; other site
504472015596	RQC domain; Region: RQC; pfam09382
504472015597	HRDC domain; Region: HRDC; pfam00570
504472015598	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
504472015599	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
504472015600	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
504472015601	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
504472015602	PSP1 C-terminal conserved region; Region: PSP1; cl00770
504472015603	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
504472015604	Penicillinase repressor; Region: Pencillinase_R; pfam03965
504472015605	GldH lipoprotein; Region: GldH_lipo; pfam14109
504472015606	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
504472015607	active site
504472015608	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472015609	amidophosphoribosyltransferase; Provisional; Region: PRK08525
504472015610	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
504472015611	active site
504472015612	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
504472015613	active site
504472015614	DNA primase, catalytic core; Region: dnaG; TIGR01391
504472015615	CHC2 zinc finger; Region: zf-CHC2; pfam01807
504472015616	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
504472015617	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
504472015618	active site
504472015619	metal binding site [ion binding]; metal-binding site
504472015620	interdomain interaction site; other site
504472015621	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472015622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472015623	active site
504472015624	phosphorylation site [posttranslational modification]
504472015625	intermolecular recognition site; other site
504472015626	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472015627	DNA binding residues [nucleotide binding]
504472015628	dimerization interface [polypeptide binding]; other site
504472015629	LytTr DNA-binding domain; Region: LytTR; smart00850
504472015630	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
504472015631	putative acyl-acceptor binding pocket; other site
504472015632	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
504472015633	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
504472015634	homodimer interface [polypeptide binding]; other site
504472015635	oligonucleotide binding site [chemical binding]; other site
504472015636	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
504472015637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472015638	TPR motif; other site
504472015639	binding surface
504472015640	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
504472015641	IHF - DNA interface [nucleotide binding]; other site
504472015642	IHF dimer interface [polypeptide binding]; other site
504472015643	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
504472015644	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
504472015645	minor groove reading motif; other site
504472015646	helix-hairpin-helix signature motif; other site
504472015647	substrate binding pocket [chemical binding]; other site
504472015648	active site
504472015649	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
504472015650	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
504472015651	DNA binding and oxoG recognition site [nucleotide binding]
504472015652	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
504472015653	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
504472015654	dimer interface [polypeptide binding]; other site
504472015655	ssDNA binding site [nucleotide binding]; other site
504472015656	tetramer (dimer of dimers) interface [polypeptide binding]; other site
504472015657	gliding motility-associated protein GldE; Region: GldE; TIGR03520
504472015658	Domain of unknown function DUF21; Region: DUF21; pfam01595
504472015659	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
504472015660	Transporter associated domain; Region: CorC_HlyC; smart01091
504472015661	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
504472015662	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
504472015663	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
504472015664	Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483
504472015665	active site
504472015666	catalytic triad [active]
504472015667	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
504472015668	active site
504472015669	catalytic triad [active]
504472015670	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472015671	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
504472015672	active site
504472015673	catalytic triad [active]
504472015674	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472015675	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
504472015676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
504472015677	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
504472015678	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472015679	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
504472015680	Protein of unknown function, DUF481; Region: DUF481; cl01213
504472015681	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472015682	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472015683	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
504472015684	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472015685	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472015686	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
504472015687	nudix motif; other site
504472015688	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
504472015689	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
504472015690	active site
504472015691	nucleotide binding site [chemical binding]; other site
504472015692	HIGH motif; other site
504472015693	KMSKS motif; other site
504472015694	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472015695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
504472015696	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472015697	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
504472015698	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
504472015699	dimerization interface [polypeptide binding]; other site
504472015700	ATP binding site [chemical binding]; other site
504472015701	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
504472015702	generic binding surface I; other site
504472015703	generic binding surface II; other site
504472015704	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
504472015705	putative catalytic site [active]
504472015706	putative metal binding site [ion binding]; other site
504472015707	putative phosphate binding site [ion binding]; other site
504472015708	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472015709	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472015710	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472015711	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472015712	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472015713	Outer membrane efflux protein; Region: OEP; pfam02321
504472015714	Outer membrane efflux protein; Region: OEP; pfam02321
504472015715	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472015716	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472015717	WHG domain; Region: WHG; pfam13305
504472015718	Predicted transcriptional regulator [Transcription]; Region: COG2378
504472015719	HTH domain; Region: HTH_11; cl17392
504472015720	WYL domain; Region: WYL; pfam13280
504472015721	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
504472015722	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
504472015723	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
504472015724	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
504472015725	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
504472015726	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
504472015727	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
504472015728	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
504472015729	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
504472015730	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
504472015731	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472015732	putative catalytic residue [active]
504472015733	SurA N-terminal domain; Region: SurA_N_3; cl07813
504472015734	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
504472015735	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
504472015736	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
504472015737	active site
504472015738	dimerization interface [polypeptide binding]; other site
504472015739	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472015740	DHH family; Region: DHH; pfam01368
504472015741	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
504472015742	active site
504472015743	multimer interface [polypeptide binding]; other site
504472015744	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
504472015745	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
504472015746	minor groove reading motif; other site
504472015747	helix-hairpin-helix signature motif; other site
504472015748	substrate binding pocket [chemical binding]; other site
504472015749	active site
504472015750	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
504472015751	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
504472015752	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472015753	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472015754	DNA binding residues [nucleotide binding]
504472015755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472015756	binding surface
504472015757	TPR motif; other site
504472015758	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472015759	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472015760	Histidine kinase; Region: HisKA_3; pfam07730
504472015761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472015762	ATP binding site [chemical binding]; other site
504472015763	Mg2+ binding site [ion binding]; other site
504472015764	G-X-G motif; other site
504472015765	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
504472015766	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
504472015767	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472015768	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
504472015769	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
504472015770	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
504472015771	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472015772	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
504472015773	PA/protease or protease-like domain interface [polypeptide binding]; other site
504472015774	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
504472015775	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472015776	metal binding site [ion binding]; metal-binding site
504472015777	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472015778	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472015779	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472015780	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472015781	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472015782	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472015783	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
504472015784	Family of unknown function (DUF706); Region: DUF706; pfam05153
504472015785	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
504472015786	Zn binding site [ion binding]; other site
504472015787	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
504472015788	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
504472015789	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
504472015790	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
504472015791	active site
504472015792	putative substrate binding pocket [chemical binding]; other site
504472015793	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472015794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472015795	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472015796	active site
504472015797	phosphorylation site [posttranslational modification]
504472015798	intermolecular recognition site; other site
504472015799	dimerization interface [polypeptide binding]; other site
504472015800	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
504472015801	dimer interface [polypeptide binding]; other site
504472015802	phosphorylation site [posttranslational modification]
504472015803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472015804	ATP binding site [chemical binding]; other site
504472015805	Mg2+ binding site [ion binding]; other site
504472015806	G-X-G motif; other site
504472015807	Response regulator receiver domain; Region: Response_reg; pfam00072
504472015808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472015809	active site
504472015810	phosphorylation site [posttranslational modification]
504472015811	intermolecular recognition site; other site
504472015812	dimerization interface [polypeptide binding]; other site
504472015813	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472015814	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472015815	Trehalase; Region: Trehalase; cl17346
504472015816	hypothetical protein; Provisional; Region: PRK04081
504472015817	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
504472015818	hydroxyglutarate oxidase; Provisional; Region: PRK11728
504472015819	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472015820	Sulfatase; Region: Sulfatase; pfam00884
504472015821	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472015822	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472015823	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472015824	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472015825	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472015826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
504472015827	Putative glucoamylase; Region: Glycoamylase; pfam10091
504472015828	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472015829	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472015830	Mechanosensitive ion channel; Region: MS_channel; pfam00924
504472015831	Ycf2; Provisional; Region: ycf2; CHL00206
504472015832	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472015833	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
504472015834	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
504472015835	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
504472015836	Curli assembly protein CsgE; Region: CsgE; cl08115
504472015837	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
504472015838	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
504472015839	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
504472015840	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
504472015841	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
504472015842	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
504472015843	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
504472015844	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472015845	active site pocket [active]
504472015846	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
504472015847	TIGR01777 family protein; Region: yfcH
504472015848	putative NAD(P) binding site [chemical binding]; other site
504472015849	putative active site [active]
504472015850	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
504472015851	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
504472015852	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
504472015853	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472015854	MarR family; Region: MarR_2; pfam12802
504472015855	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
504472015856	Coenzyme A binding pocket [chemical binding]; other site
504472015857	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
504472015858	active site
504472015859	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
504472015860	Ricin-type beta-trefoil; Region: RICIN; smart00458
504472015861	DinB family; Region: DinB; cl17821
504472015862	DinB superfamily; Region: DinB_2; pfam12867
504472015863	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
504472015864	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
504472015865	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472015866	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
504472015867	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
504472015868	DNA polymerase III subunit delta'; Validated; Region: PRK05564
504472015869	DNA polymerase III subunit delta'; Validated; Region: PRK08485
504472015870	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
504472015871	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
504472015872	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
504472015873	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472015874	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
504472015875	Protein of unknown function, DUF608; Region: DUF608; pfam04685
504472015876	Uncharacterized conserved protein [Function unknown]; Region: COG5646
504472015877	Protein of unknown function, DUF399; Region: DUF399; pfam04187
504472015878	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472015879	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472015880	ligand binding site [chemical binding]; other site
504472015881	flexible hinge region; other site
504472015882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
504472015883	dimer interface [polypeptide binding]; other site
504472015884	phosphorylation site [posttranslational modification]
504472015885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472015886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472015887	ATP binding site [chemical binding]; other site
504472015888	Mg2+ binding site [ion binding]; other site
504472015889	G-X-G motif; other site
504472015890	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472015891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472015892	active site
504472015893	phosphorylation site [posttranslational modification]
504472015894	intermolecular recognition site; other site
504472015895	dimerization interface [polypeptide binding]; other site
504472015896	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
504472015897	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
504472015898	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
504472015899	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
504472015900	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
504472015901	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
504472015902	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
504472015903	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
504472015904	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
504472015905	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
504472015906	Ligand binding site; other site
504472015907	Putative Catalytic site; other site
504472015908	DXD motif; other site
504472015909	protoporphyrinogen oxidase; Region: PLN02576
504472015910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472015911	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
504472015912	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
504472015913	metal ion-dependent adhesion site (MIDAS); other site
504472015914	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
504472015915	metal ion-dependent adhesion site (MIDAS); other site
504472015916	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
504472015917	RNA/DNA hybrid binding site [nucleotide binding]; other site
504472015918	active site
504472015919	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
504472015920	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
504472015921	substrate binding site [chemical binding]; other site
504472015922	oxyanion hole (OAH) forming residues; other site
504472015923	trimer interface [polypeptide binding]; other site
504472015924	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
504472015925	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
504472015926	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
504472015927	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
504472015928	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
504472015929	dimer interface [polypeptide binding]; other site
504472015930	active site
504472015931	Aegerolysin; Region: Aegerolysin; pfam06355
504472015932	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
504472015933	Phage Tail Collar Domain; Region: Collar; pfam07484
504472015934	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
504472015935	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
504472015936	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
504472015937	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472015938	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472015939	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472015940	DNA binding residues [nucleotide binding]
504472015941	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472015942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472015943	active site
504472015944	phosphorylation site [posttranslational modification]
504472015945	intermolecular recognition site; other site
504472015946	dimerization interface [polypeptide binding]; other site
504472015947	LytTr DNA-binding domain; Region: LytTR; smart00850
504472015948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472015949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472015950	ATP binding site [chemical binding]; other site
504472015951	Mg2+ binding site [ion binding]; other site
504472015952	G-X-G motif; other site
504472015953	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
504472015954	protein-splicing catalytic site; other site
504472015955	thioester formation/cholesterol transfer; other site
504472015956	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
504472015957	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
504472015958	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
504472015959	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472015960	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472015961	homodimer interface [polypeptide binding]; other site
504472015962	catalytic residue [active]
504472015963	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
504472015964	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472015965	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472015966	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472015967	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
504472015968	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472015969	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
504472015970	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472015971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472015972	catalytic residue [active]
504472015973	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
504472015974	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472015975	putative metal binding site [ion binding]; other site
504472015976	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
504472015977	Interdomain contacts; other site
504472015978	Cytokine receptor motif; other site
504472015979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
504472015980	FtsI repressor; Provisional; Region: PRK10883
504472015981	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
504472015982	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
504472015983	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472015984	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
504472015985	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
504472015986	dimer interface [polypeptide binding]; other site
504472015987	putative tRNA-binding site [nucleotide binding]; other site
504472015988	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
504472015989	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472015990	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472015991	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
504472015992	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
504472015993	PhnA protein; Region: PhnA; pfam03831
504472015994	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472015995	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472015996	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
504472015997	Active_site [active]
504472015998	Peptidase family S41; Region: Peptidase_S41; pfam03572
504472015999	Active site serine [active]
504472016000	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
504472016001	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472016002	Helix-turn-helix domain; Region: HTH_36; pfam13730
504472016003	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
504472016004	active site
504472016005	catalytic residues [active]
504472016006	DNA binding site [nucleotide binding]
504472016007	Int/Topo IB signature motif; other site
504472016008	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472016009	Integrase core domain; Region: rve; pfam00665
504472016010	transposase/IS protein; Provisional; Region: PRK09183
504472016011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472016012	Walker A motif; other site
504472016013	ATP binding site [chemical binding]; other site
504472016014	Walker B motif; other site
504472016015	arginine finger; other site
504472016016	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
504472016017	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472016018	active site
504472016019	DNA binding site [nucleotide binding]
504472016020	Int/Topo IB signature motif; other site
504472016021	Helix-turn-helix; Region: HTH_3; pfam01381
504472016022	Domain of unknown function (DUF955); Region: DUF955; cl01076
504472016023	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
504472016024	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
504472016025	HTH-like domain; Region: HTH_21; pfam13276
504472016026	Integrase core domain; Region: rve; pfam00665
504472016027	Integrase core domain; Region: rve_3; pfam13683
504472016028	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
504472016029	DNA-binding interface [nucleotide binding]; DNA binding site
504472016030	Winged helix-turn helix; Region: HTH_29; pfam13551
504472016031	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472016032	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472016033	ligand binding site [chemical binding]; other site
504472016034	flexible hinge region; other site
504472016035	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
504472016036	non-specific DNA interactions [nucleotide binding]; other site
504472016037	DNA binding site [nucleotide binding]
504472016038	sequence specific DNA binding site [nucleotide binding]; other site
504472016039	putative cAMP binding site [chemical binding]; other site
504472016040	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
504472016041	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
504472016042	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472016043	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472016044	active site residue [active]
504472016045	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472016046	active site residue [active]
504472016047	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
504472016048	active site
504472016049	catalytic residues [active]
504472016050	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
504472016051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
504472016052	ATP binding site [chemical binding]; other site
504472016053	putative Mg++ binding site [ion binding]; other site
504472016054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
504472016055	nucleotide binding region [chemical binding]; other site
504472016056	ATP-binding site [chemical binding]; other site
504472016057	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
504472016058	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
504472016059	active site
504472016060	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
504472016061	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
504472016062	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
504472016063	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
504472016064	DNA photolyase; Region: DNA_photolyase; pfam00875
504472016065	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
504472016066	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
504472016067	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
504472016068	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472016069	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
504472016070	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016071	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472016072	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
504472016073	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472016074	Penicillinase repressor; Region: Pencillinase_R; pfam03965
504472016075	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
504472016076	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
504472016077	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
504472016078	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
504472016079	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
504472016080	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
504472016081	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472016082	active site pocket [active]
504472016083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472016084	D-galactonate transporter; Region: 2A0114; TIGR00893
504472016085	putative substrate translocation pore; other site
504472016086	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
504472016087	mannonate dehydratase; Provisional; Region: PRK03906
504472016088	mannonate dehydratase; Region: uxuA; TIGR00695
504472016089	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
504472016090	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
504472016091	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
504472016092	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
504472016093	classical (c) SDRs; Region: SDR_c; cd05233
504472016094	NAD(P) binding site [chemical binding]; other site
504472016095	active site
504472016096	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
504472016097	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472016098	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
504472016099	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
504472016100	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
504472016101	TIR domain; Region: TIR_2; pfam13676
504472016102	Ubiquitin-like proteins; Region: UBQ; cd00196
504472016103	charged pocket; other site
504472016104	hydrophobic patch; other site
504472016105	SCP-2 sterol transfer family; Region: SCP2; pfam02036
504472016106	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472016107	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472016108	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
504472016109	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472016110	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
504472016111	Histidine kinase; Region: HisKA_3; pfam07730
504472016112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016113	ATP binding site [chemical binding]; other site
504472016114	Mg2+ binding site [ion binding]; other site
504472016115	G-X-G motif; other site
504472016116	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
504472016117	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
504472016118	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
504472016119	catalytic site [active]
504472016120	active site
504472016121	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
504472016122	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472016123	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
504472016124	HEAT repeats; Region: HEAT_2; pfam13646
504472016125	HEAT repeats; Region: HEAT_2; pfam13646
504472016126	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
504472016127	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
504472016128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472016129	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
504472016130	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472016131	active site
504472016132	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
504472016133	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
504472016134	active site
504472016135	trimer interface [polypeptide binding]; other site
504472016136	allosteric site; other site
504472016137	active site lid [active]
504472016138	hexamer (dimer of trimers) interface [polypeptide binding]; other site
504472016139	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472016140	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472016141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472016142	S-adenosylmethionine binding site [chemical binding]; other site
504472016143	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
504472016144	Phosphoesterase family; Region: Phosphoesterase; pfam04185
504472016145	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
504472016146	structural tetrad; other site
504472016147	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
504472016148	homoserine kinase; Provisional; Region: PRK01212
504472016149	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
504472016150	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
504472016151	oligomeric interface; other site
504472016152	putative active site [active]
504472016153	homodimer interface [polypeptide binding]; other site
504472016154	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
504472016155	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472016156	active site
504472016157	Fn3 associated; Region: Fn3_assoc; pfam13287
504472016158	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
504472016159	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472016160	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472016161	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
504472016162	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
504472016163	SnoaL-like domain; Region: SnoaL_2; pfam12680
504472016164	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
504472016165	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
504472016166	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
504472016167	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472016168	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472016169	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016170	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472016171	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
504472016172	Protein of unknown function DUF262; Region: DUF262; pfam03235
504472016173	Protein of unknown function DUF262; Region: DUF262; pfam03235
504472016174	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
504472016175	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472016176	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
504472016177	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
504472016178	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
504472016179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472016180	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
504472016181	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
504472016182	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472016183	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
504472016184	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
504472016185	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
504472016186	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
504472016187	ATP-grasp domain; Region: ATP-grasp_4; cl17255
504472016188	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
504472016189	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472016190	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472016191	active site
504472016192	catalytic tetrad [active]
504472016193	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
504472016194	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
504472016195	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472016196	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
504472016197	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
504472016198	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472016199	catalytic loop [active]
504472016200	iron binding site [ion binding]; other site
504472016201	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
504472016202	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
504472016203	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472016204	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472016205	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
504472016206	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
504472016207	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
504472016208	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
504472016209	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472016210	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472016211	active site
504472016212	catalytic tetrad [active]
504472016213	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
504472016214	RibD C-terminal domain; Region: RibD_C; cl17279
504472016215	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
504472016216	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139
504472016217	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
504472016218	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472016219	HEAT repeats; Region: HEAT_2; pfam13646
504472016220	Cytochrome c; Region: Cytochrom_C; cl11414
504472016221	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
504472016222	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
504472016223	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
504472016224	HflX GTPase family; Region: HflX; cd01878
504472016225	G1 box; other site
504472016226	GTP/Mg2+ binding site [chemical binding]; other site
504472016227	Switch I region; other site
504472016228	G2 box; other site
504472016229	G3 box; other site
504472016230	Switch II region; other site
504472016231	G4 box; other site
504472016232	G5 box; other site
504472016233	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
504472016234	HsdM N-terminal domain; Region: HsdM_N; pfam12161
504472016235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472016236	S-adenosylmethionine binding site [chemical binding]; other site
504472016237	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
504472016238	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
504472016239	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
504472016240	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
504472016241	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
504472016242	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
504472016243	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
504472016244	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
504472016245	ATP binding site [chemical binding]; other site
504472016246	putative Mg++ binding site [ion binding]; other site
504472016247	Putative esterase; Region: Esterase; pfam00756
504472016248	S-formylglutathione hydrolase; Region: PLN02442
504472016249	exoribonuclease R; Provisional; Region: PRK11642
504472016250	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
504472016251	heme-binding site [chemical binding]; other site
504472016252	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254
504472016253	active site
504472016254	dimer interface [polypeptide binding]; other site
504472016255	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
504472016256	Flavodoxin; Region: Flavodoxin_1; pfam00258
504472016257	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
504472016258	FAD binding pocket [chemical binding]; other site
504472016259	conserved FAD binding motif [chemical binding]; other site
504472016260	phosphate binding motif [ion binding]; other site
504472016261	beta-alpha-beta structure motif; other site
504472016262	NAD binding pocket [chemical binding]; other site
504472016263	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472016264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016265	active site
504472016266	phosphorylation site [posttranslational modification]
504472016267	intermolecular recognition site; other site
504472016268	dimerization interface [polypeptide binding]; other site
504472016269	LytTr DNA-binding domain; Region: LytTR; smart00850
504472016270	PAS domain S-box; Region: sensory_box; TIGR00229
504472016271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472016272	putative active site [active]
504472016273	heme pocket [chemical binding]; other site
504472016274	PAS fold; Region: PAS_4; pfam08448
504472016275	PAS domain S-box; Region: sensory_box; TIGR00229
504472016276	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472016277	putative active site [active]
504472016278	heme pocket [chemical binding]; other site
504472016279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472016280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472016281	dimer interface [polypeptide binding]; other site
504472016282	phosphorylation site [posttranslational modification]
504472016283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016284	ATP binding site [chemical binding]; other site
504472016285	Mg2+ binding site [ion binding]; other site
504472016286	G-X-G motif; other site
504472016287	Response regulator receiver domain; Region: Response_reg; pfam00072
504472016288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016289	active site
504472016290	phosphorylation site [posttranslational modification]
504472016291	intermolecular recognition site; other site
504472016292	dimerization interface [polypeptide binding]; other site
504472016293	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
504472016294	Heme NO binding; Region: HNOB; pfam07700
504472016295	short chain dehydrogenase; Provisional; Region: PRK06914
504472016296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472016297	NAD(P) binding site [chemical binding]; other site
504472016298	active site
504472016299	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
504472016300	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
504472016301	Family description; Region: VCBS; pfam13517
504472016302	hypothetical protein; Provisional; Region: PRK09256
504472016303	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472016304	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472016305	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472016306	DNA binding residues [nucleotide binding]
504472016307	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
504472016308	FecR protein; Region: FecR; pfam04773
504472016309	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472016310	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016311	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472016312	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472016313	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472016314	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472016315	Sulfatase; Region: Sulfatase; pfam00884
504472016316	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
504472016317	Sulfatase; Region: Sulfatase; pfam00884
504472016318	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
504472016319	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
504472016320	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
504472016321	putative sugar binding sites [chemical binding]; other site
504472016322	Q-X-W motif; other site
504472016323	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472016324	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472016325	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
504472016326	NAD binding site [chemical binding]; other site
504472016327	homotetramer interface [polypeptide binding]; other site
504472016328	homodimer interface [polypeptide binding]; other site
504472016329	active site
504472016330	substrate binding site [chemical binding]; other site
504472016331	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
504472016332	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
504472016333	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
504472016334	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472016335	putative glycosyl transferase; Provisional; Region: PRK10307
504472016336	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
504472016337	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
504472016338	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
504472016339	putative metal binding site; other site
504472016340	putative acyl transferase; Provisional; Region: PRK10502
504472016341	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
504472016342	putative trimer interface [polypeptide binding]; other site
504472016343	putative active site [active]
504472016344	putative substrate binding site [chemical binding]; other site
504472016345	putative CoA binding site [chemical binding]; other site
504472016346	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016347	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
504472016348	putative ADP-binding pocket [chemical binding]; other site
504472016349	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
504472016350	trimer interface [polypeptide binding]; other site
504472016351	active site
504472016352	substrate binding site [chemical binding]; other site
504472016353	CoA binding site [chemical binding]; other site
504472016354	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016355	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
504472016356	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016357	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472016358	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
504472016359	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
504472016360	active site
504472016361	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472016362	Acyltransferase family; Region: Acyl_transf_3; pfam01757
504472016363	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016364	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472016365	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
504472016366	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
504472016367	transcriptional activator RfaH; Region: RfaH; TIGR01955
504472016368	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
504472016369	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
504472016370	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472016371	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472016372	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472016373	SLBB domain; Region: SLBB; pfam10531
504472016374	Bacterial sugar transferase; Region: Bac_transf; pfam02397
504472016375	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
504472016376	active site
504472016377	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472016378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472016379	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
504472016380	TraB family; Region: TraB; pfam01963
504472016381	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
504472016382	fumarylacetoacetase; Region: PLN02856
504472016383	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
504472016384	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
504472016385	Transcriptional regulators [Transcription]; Region: MarR; COG1846
504472016386	MarR family; Region: MarR_2; pfam12802
504472016387	MarR family; Region: MarR_2; cl17246
504472016388	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
504472016389	cofactor binding site; other site
504472016390	metal binding site [ion binding]; metal-binding site
504472016391	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
504472016392	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
504472016393	dimer interface [polypeptide binding]; other site
504472016394	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
504472016395	active site
504472016396	Fe binding site [ion binding]; other site
504472016397	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
504472016398	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
504472016399	active site
504472016400	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
504472016401	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
504472016402	Amidase; Region: Amidase; cl11426
504472016403	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
504472016404	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
504472016405	CoA-binding site [chemical binding]; other site
504472016406	ATP-binding [chemical binding]; other site
504472016407	Preprotein translocase subunit; Region: YajC; pfam02699
504472016408	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
504472016409	YtxH-like protein; Region: YtxH; pfam12732
504472016410	transcription antitermination factor NusB; Region: nusB; TIGR01951
504472016411	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
504472016412	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472016413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472016414	Walker A/P-loop; other site
504472016415	ATP binding site [chemical binding]; other site
504472016416	Q-loop/lid; other site
504472016417	ABC transporter signature motif; other site
504472016418	Walker B; other site
504472016419	D-loop; other site
504472016420	H-loop/switch region; other site
504472016421	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
504472016422	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
504472016423	dimer interface [polypeptide binding]; other site
504472016424	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
504472016425	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
504472016426	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472016427	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
504472016428	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
504472016429	HEAT repeats; Region: HEAT_2; pfam13646
504472016430	Family description; Region: VCBS; pfam13517
504472016431	Family description; Region: VCBS; pfam13517
504472016432	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472016433	AAA domain; Region: AAA_21; pfam13304
504472016434	Walker A/P-loop; other site
504472016435	ATP binding site [chemical binding]; other site
504472016436	TIGR02646 family protein; Region: TIGR02646
504472016437	DinB superfamily; Region: DinB_2; pfam12867
504472016438	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
504472016439	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
504472016440	SnoaL-like domain; Region: SnoaL_3; pfam13474
504472016441	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
504472016442	intracellular protease, PfpI family; Region: PfpI; TIGR01382
504472016443	proposed catalytic triad [active]
504472016444	conserved cys residue [active]
504472016445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472016446	putative DNA binding site [nucleotide binding]; other site
504472016447	putative Zn2+ binding site [ion binding]; other site
504472016448	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
504472016449	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
504472016450	FMN binding site [chemical binding]; other site
504472016451	active site
504472016452	substrate binding site [chemical binding]; other site
504472016453	catalytic residue [active]
504472016454	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
504472016455	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
504472016456	putative active site [active]
504472016457	catalytic triad [active]
504472016458	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
504472016459	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
504472016460	active site
504472016461	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
504472016462	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472016463	catalytic residue [active]
504472016464	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
504472016465	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
504472016466	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
504472016467	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
504472016468	active site
504472016469	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
504472016470	active site 2 [active]
504472016471	active site 1 [active]
504472016472	Predicted membrane protein [Function unknown]; Region: COG2860
504472016473	UPF0126 domain; Region: UPF0126; pfam03458
504472016474	UPF0126 domain; Region: UPF0126; pfam03458
504472016475	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
504472016476	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
504472016477	ATP cone domain; Region: ATP-cone; pfam03477
504472016478	Class I ribonucleotide reductase; Region: RNR_I; cd01679
504472016479	active site
504472016480	dimer interface [polypeptide binding]; other site
504472016481	catalytic residues [active]
504472016482	effector binding site; other site
504472016483	R2 peptide binding site; other site
504472016484	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472016485	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472016486	DNA binding site [nucleotide binding]
504472016487	domain linker motif; other site
504472016488	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472016489	dimerization interface [polypeptide binding]; other site
504472016490	ligand binding site [chemical binding]; other site
504472016491	LytTr DNA-binding domain; Region: LytTR; smart00850
504472016492	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
504472016493	thiamine pyrophosphate protein; Provisional; Region: PRK08273
504472016494	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
504472016495	PYR/PP interface [polypeptide binding]; other site
504472016496	dimer interface [polypeptide binding]; other site
504472016497	tetramer interface [polypeptide binding]; other site
504472016498	TPP binding site [chemical binding]; other site
504472016499	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
504472016500	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
504472016501	TPP-binding site [chemical binding]; other site
504472016502	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472016503	S-adenosylmethionine binding site [chemical binding]; other site
504472016504	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
504472016505	FAD binding domain; Region: FAD_binding_4; pfam01565
504472016506	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
504472016507	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472016508	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472016509	active site
504472016510	metal binding site [ion binding]; metal-binding site
504472016511	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472016512	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
504472016513	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472016514	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472016515	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
504472016516	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016517	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472016518	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472016519	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472016520	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
504472016521	substrate binding site [chemical binding]; other site
504472016522	ATP binding site [chemical binding]; other site
504472016523	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
504472016524	putative active cleft [active]
504472016525	dimerization interface [polypeptide binding]; other site
504472016526	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472016527	catalytic residues [active]
504472016528	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
504472016529	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
504472016530	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
504472016531	dimerization interface [polypeptide binding]; other site
504472016532	active site
504472016533	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
504472016534	hypothetical protein; Validated; Region: PRK00153
504472016535	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
504472016536	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
504472016537	Probable Catalytic site; other site
504472016538	metal-binding site
504472016539	PspC domain; Region: PspC; pfam04024
504472016540	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
504472016541	DNA-binding site [nucleotide binding]; DNA binding site
504472016542	RNA-binding motif; other site
504472016543	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
504472016544	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
504472016545	dimer interface [polypeptide binding]; other site
504472016546	putative anticodon binding site; other site
504472016547	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
504472016548	motif 1; other site
504472016549	active site
504472016550	motif 2; other site
504472016551	motif 3; other site
504472016552	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
504472016553	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
504472016554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
504472016555	Type III pantothenate kinase; Region: Pan_kinase; cl17198
504472016556	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
504472016557	Glycoprotease family; Region: Peptidase_M22; pfam00814
504472016558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472016559	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
504472016560	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
504472016561	SLBB domain; Region: SLBB; pfam10531
504472016562	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
504472016563	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
504472016564	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
504472016565	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
504472016566	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
504472016567	Bacterial sugar transferase; Region: Bac_transf; pfam02397
504472016568	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
504472016569	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
504472016570	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016571	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
504472016572	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
504472016573	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
504472016574	trimer interface [polypeptide binding]; other site
504472016575	active site
504472016576	substrate binding site [chemical binding]; other site
504472016577	CoA binding site [chemical binding]; other site
504472016578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016579	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
504472016580	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016581	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
504472016582	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
504472016583	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472016584	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
504472016585	NAD binding site [chemical binding]; other site
504472016586	homotetramer interface [polypeptide binding]; other site
504472016587	homodimer interface [polypeptide binding]; other site
504472016588	active site
504472016589	substrate binding site [chemical binding]; other site
504472016590	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
504472016591	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
504472016592	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
504472016593	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
504472016594	putative active site [active]
504472016595	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
504472016596	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
504472016597	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
504472016598	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
504472016599	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
504472016600	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472016601	NAD(P) binding site [chemical binding]; other site
504472016602	active site
504472016603	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
504472016604	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
504472016605	Ligand binding site; other site
504472016606	Putative Catalytic site; other site
504472016607	DXD motif; other site
504472016608	PHP domain; Region: PHP; pfam02811
504472016609	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472016610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016611	ATP binding site [chemical binding]; other site
504472016612	Mg2+ binding site [ion binding]; other site
504472016613	G-X-G motif; other site
504472016614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016615	ATP binding site [chemical binding]; other site
504472016616	Mg2+ binding site [ion binding]; other site
504472016617	G-X-G motif; other site
504472016618	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472016619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016620	active site
504472016621	phosphorylation site [posttranslational modification]
504472016622	intermolecular recognition site; other site
504472016623	dimerization interface [polypeptide binding]; other site
504472016624	LytTr DNA-binding domain; Region: LytTR; smart00850
504472016625	Esterase/lipase [General function prediction only]; Region: COG1647
504472016626	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
504472016627	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472016628	LytTr DNA-binding domain; Region: LytTR; smart00850
504472016629	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
504472016630	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
504472016631	active site
504472016632	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472016633	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472016634	SusD family; Region: SusD; pfam07980
504472016635	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472016636	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016637	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472016638	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
504472016639	active site
504472016640	catalytic residues [active]
504472016641	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472016642	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472016643	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472016644	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
504472016645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472016646	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472016647	dimer interface [polypeptide binding]; other site
504472016648	phosphorylation site [posttranslational modification]
504472016649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016650	ATP binding site [chemical binding]; other site
504472016651	Mg2+ binding site [ion binding]; other site
504472016652	G-X-G motif; other site
504472016653	Response regulator receiver domain; Region: Response_reg; pfam00072
504472016654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016655	active site
504472016656	phosphorylation site [posttranslational modification]
504472016657	intermolecular recognition site; other site
504472016658	dimerization interface [polypeptide binding]; other site
504472016659	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472016660	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472016661	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
504472016662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016663	TPR motif; other site
504472016664	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
504472016665	binding surface
504472016666	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472016667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016668	binding surface
504472016669	TPR motif; other site
504472016670	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472016671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472016672	Histidine kinase; Region: HisKA_3; pfam07730
504472016673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016674	ATP binding site [chemical binding]; other site
504472016675	Mg2+ binding site [ion binding]; other site
504472016676	G-X-G motif; other site
504472016677	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472016678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016679	active site
504472016680	phosphorylation site [posttranslational modification]
504472016681	intermolecular recognition site; other site
504472016682	dimerization interface [polypeptide binding]; other site
504472016683	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472016684	DNA binding residues [nucleotide binding]
504472016685	dimerization interface [polypeptide binding]; other site
504472016686	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
504472016687	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
504472016688	WHG domain; Region: WHG; pfam13305
504472016689	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
504472016690	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
504472016691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
504472016692	NAD(P) binding site [chemical binding]; other site
504472016693	active site
504472016694	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
504472016695	Protein of unknown function, DUF608; Region: DUF608; pfam04685
504472016696	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472016697	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472016698	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472016699	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016700	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472016701	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472016702	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472016703	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
504472016704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472016705	S-adenosylmethionine binding site [chemical binding]; other site
504472016706	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
504472016707	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
504472016708	active site
504472016709	dimer interface [polypeptide binding]; other site
504472016710	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
504472016711	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472016712	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472016713	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745
504472016714	Caspase domain; Region: Peptidase_C14; pfam00656
504472016715	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016716	TPR motif; other site
504472016717	binding surface
504472016718	TPR repeat; Region: TPR_11; pfam13414
504472016719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016720	binding surface
504472016721	TPR motif; other site
504472016722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016723	binding surface
504472016724	TPR motif; other site
504472016725	Caspase domain; Region: Peptidase_C14; pfam00656
504472016726	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
504472016727	Peptidase family M48; Region: Peptidase_M48; cl12018
504472016728	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
504472016729	Caspase domain; Region: Peptidase_C14; pfam00656
504472016730	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016731	binding surface
504472016732	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472016733	TPR motif; other site
504472016734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016735	TPR motif; other site
504472016736	binding surface
504472016737	TPR repeat; Region: TPR_11; pfam13414
504472016738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472016739	binding surface
504472016740	TPR motif; other site
504472016741	TPR repeat; Region: TPR_11; pfam13414
504472016742	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472016743	transposase/IS protein; Provisional; Region: PRK09183
504472016744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472016745	Walker A motif; other site
504472016746	ATP binding site [chemical binding]; other site
504472016747	Walker B motif; other site
504472016748	arginine finger; other site
504472016749	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472016750	Integrase core domain; Region: rve; pfam00665
504472016751	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472016752	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
504472016753	catalytic triad [active]
504472016754	putative active site [active]
504472016755	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
504472016756	Virulence factor SrfB; Region: SrfB; pfam07520
504472016757	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
504472016758	active site
504472016759	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472016760	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472016761	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472016762	DNA binding residues [nucleotide binding]
504472016763	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472016764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016765	active site
504472016766	phosphorylation site [posttranslational modification]
504472016767	intermolecular recognition site; other site
504472016768	dimerization interface [polypeptide binding]; other site
504472016769	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472016770	DNA binding residues [nucleotide binding]
504472016771	dimerization interface [polypeptide binding]; other site
504472016772	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
504472016773	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
504472016774	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472016775	YniB-like protein; Region: YniB; pfam14002
504472016776	Histidine kinase; Region: HisKA_3; pfam07730
504472016777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016778	ATP binding site [chemical binding]; other site
504472016779	Mg2+ binding site [ion binding]; other site
504472016780	G-X-G motif; other site
504472016781	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
504472016782	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
504472016783	Zn2+ binding site [ion binding]; other site
504472016784	Mg2+ binding site [ion binding]; other site
504472016785	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
504472016786	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
504472016787	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
504472016788	trimer interface [polypeptide binding]; other site
504472016789	active site
504472016790	UDP-GlcNAc binding site [chemical binding]; other site
504472016791	lipid binding site [chemical binding]; lipid-binding site
504472016792	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
504472016793	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
504472016794	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
504472016795	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
504472016796	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
504472016797	active site
504472016798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
504472016799	Walker A/P-loop; other site
504472016800	ATP binding site [chemical binding]; other site
504472016801	ABC transporter; Region: ABC_tran; pfam00005
504472016802	Q-loop/lid; other site
504472016803	ABC transporter signature motif; other site
504472016804	Walker B; other site
504472016805	D-loop; other site
504472016806	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
504472016807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
504472016808	S-adenosylmethionine binding site [chemical binding]; other site
504472016809	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
504472016810	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
504472016811	FtsX-like permease family; Region: FtsX; pfam02687
504472016812	FtsX-like permease family; Region: FtsX; pfam02687
504472016813	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
504472016814	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
504472016815	Walker A/P-loop; other site
504472016816	ATP binding site [chemical binding]; other site
504472016817	Q-loop/lid; other site
504472016818	ABC transporter signature motif; other site
504472016819	Walker B; other site
504472016820	D-loop; other site
504472016821	H-loop/switch region; other site
504472016822	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
504472016823	active site
504472016824	catalytic triad [active]
504472016825	oxyanion hole [active]
504472016826	switch loop; other site
504472016827	Surface antigen; Region: Bac_surface_Ag; pfam01103
504472016828	Family of unknown function (DUF490); Region: DUF490; pfam04357
504472016829	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
504472016830	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
504472016831	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472016832	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
504472016833	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
504472016834	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
504472016835	putative ribose interaction site [chemical binding]; other site
504472016836	putative ADP binding site [chemical binding]; other site
504472016837	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
504472016838	substrate binding site [chemical binding]; other site
504472016839	active site
504472016840	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
504472016841	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
504472016842	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
504472016843	Predicted transcriptional regulators [Transcription]; Region: COG1695
504472016844	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
504472016845	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
504472016846	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
504472016847	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
504472016848	Walker A/P-loop; other site
504472016849	ATP binding site [chemical binding]; other site
504472016850	Q-loop/lid; other site
504472016851	ABC transporter signature motif; other site
504472016852	Walker B; other site
504472016853	D-loop; other site
504472016854	H-loop/switch region; other site
504472016855	Uncharacterized conserved protein [Function unknown]; Region: COG1912
504472016856	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
504472016857	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
504472016858	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
504472016859	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
504472016860	hinge; other site
504472016861	active site
504472016862	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
504472016863	multidrug efflux protein; Reviewed; Region: PRK01766
504472016864	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
504472016865	cation binding site [ion binding]; other site
504472016866	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
504472016867	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
504472016868	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
504472016869	protein binding site [polypeptide binding]; other site
504472016870	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
504472016871	Catalytic dyad [active]
504472016872	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
504472016873	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
504472016874	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
504472016875	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
504472016876	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
504472016877	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
504472016878	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
504472016879	beta subunit interaction interface [polypeptide binding]; other site
504472016880	Walker A motif; other site
504472016881	ATP binding site [chemical binding]; other site
504472016882	Walker B motif; other site
504472016883	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
504472016884	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
504472016885	core domain interface [polypeptide binding]; other site
504472016886	delta subunit interface [polypeptide binding]; other site
504472016887	epsilon subunit interface [polypeptide binding]; other site
504472016888	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
504472016889	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
504472016890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472016891	active site
504472016892	phosphorylation site [posttranslational modification]
504472016893	intermolecular recognition site; other site
504472016894	dimerization interface [polypeptide binding]; other site
504472016895	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
504472016896	DNA binding residues [nucleotide binding]
504472016897	dimerization interface [polypeptide binding]; other site
504472016898	Tetratricopeptide repeat; Region: TPR_12; pfam13424
504472016899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
504472016900	binding surface
504472016901	TPR motif; other site
504472016902	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
504472016903	Histidine kinase; Region: HisKA_3; pfam07730
504472016904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016905	ATP binding site [chemical binding]; other site
504472016906	Mg2+ binding site [ion binding]; other site
504472016907	G-X-G motif; other site
504472016908	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472016909	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472016910	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472016911	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472016912	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472016913	SusD family; Region: SusD; pfam07980
504472016914	ig-like, plexins, transcription factors; Region: IPT; smart00429
504472016915	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
504472016916	putative metal binding site [ion binding]; other site
504472016917	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
504472016918	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472016919	PAS domain; Region: PAS_9; pfam13426
504472016920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
504472016921	putative active site [active]
504472016922	heme pocket [chemical binding]; other site
504472016923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
504472016924	PAS domain; Region: PAS_9; pfam13426
504472016925	putative active site [active]
504472016926	heme pocket [chemical binding]; other site
504472016927	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
504472016928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472016929	putative active site [active]
504472016930	heme pocket [chemical binding]; other site
504472016931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472016932	dimer interface [polypeptide binding]; other site
504472016933	phosphorylation site [posttranslational modification]
504472016934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472016935	ATP binding site [chemical binding]; other site
504472016936	Mg2+ binding site [ion binding]; other site
504472016937	G-X-G motif; other site
504472016938	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
504472016939	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472016940	N-terminal plug; other site
504472016941	ligand-binding site [chemical binding]; other site
504472016942	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
504472016943	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
504472016944	Ferritin-like domain; Region: Ferritin; pfam00210
504472016945	ferroxidase diiron center [ion binding]; other site
504472016946	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472016947	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472016948	active site
504472016949	catalytic tetrad [active]
504472016950	prephenate dehydrogenase; Validated; Region: PRK08507
504472016951	Prephenate dehydrogenase; Region: PDH; pfam02153
504472016952	GxxExxY protein; Region: GxxExxY; TIGR04256
504472016953	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
504472016954	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
504472016955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472016956	homodimer interface [polypeptide binding]; other site
504472016957	catalytic residue [active]
504472016958	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
504472016959	dimer interface [polypeptide binding]; other site
504472016960	ADP-ribose binding site [chemical binding]; other site
504472016961	active site
504472016962	nudix motif; other site
504472016963	metal binding site [ion binding]; metal-binding site
504472016964	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
504472016965	active site
504472016966	tetramer interface [polypeptide binding]; other site
504472016967	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
504472016968	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
504472016969	PA/protease or protease-like domain interface [polypeptide binding]; other site
504472016970	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
504472016971	Peptidase family M28; Region: Peptidase_M28; pfam04389
504472016972	metal binding site [ion binding]; metal-binding site
504472016973	Outer membrane efflux protein; Region: OEP; pfam02321
504472016974	Outer membrane efflux protein; Region: OEP; pfam02321
504472016975	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
504472016976	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472016977	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472016978	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
504472016979	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
504472016980	NAD(P) binding site [chemical binding]; other site
504472016981	DinB superfamily; Region: DinB_2; pfam12867
504472016982	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
504472016983	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
504472016984	active site
504472016985	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
504472016986	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
504472016987	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
504472016988	inhibitor-cofactor binding pocket; inhibition site
504472016989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472016990	catalytic residue [active]
504472016991	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
504472016992	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
504472016993	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
504472016994	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
504472016995	hexamer (dimer of trimers) interface [polypeptide binding]; other site
504472016996	trimer interface [polypeptide binding]; other site
504472016997	substrate binding site [chemical binding]; other site
504472016998	Mn binding site [ion binding]; other site
504472016999	CHASE3 domain; Region: CHASE3; pfam05227
504472017000	PAS fold; Region: PAS_4; pfam08448
504472017001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472017002	putative active site [active]
504472017003	heme pocket [chemical binding]; other site
504472017004	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472017005	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472017006	dimer interface [polypeptide binding]; other site
504472017007	phosphorylation site [posttranslational modification]
504472017008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472017009	ATP binding site [chemical binding]; other site
504472017010	Mg2+ binding site [ion binding]; other site
504472017011	G-X-G motif; other site
504472017012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017013	Response regulator receiver domain; Region: Response_reg; pfam00072
504472017014	active site
504472017015	phosphorylation site [posttranslational modification]
504472017016	intermolecular recognition site; other site
504472017017	dimerization interface [polypeptide binding]; other site
504472017018	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
504472017019	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
504472017020	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
504472017021	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
504472017022	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
504472017023	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
504472017024	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
504472017025	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472017026	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472017027	DNA binding residues [nucleotide binding]
504472017028	FecR protein; Region: FecR; pfam04773
504472017029	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472017030	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472017031	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472017032	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472017033	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
504472017034	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472017035	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
504472017036	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472017037	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472017038	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
504472017039	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
504472017040	Cadherin repeat-like domain; Region: CA_like; cl15786
504472017041	Ca2+ binding site [ion binding]; other site
504472017042	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472017043	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
504472017044	thiS-thiF/thiG interaction site; other site
504472017045	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
504472017046	thiamine phosphate binding site [chemical binding]; other site
504472017047	active site
504472017048	pyrophosphate binding site [ion binding]; other site
504472017049	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
504472017050	ThiS interaction site; other site
504472017051	putative active site [active]
504472017052	tetramer interface [polypeptide binding]; other site
504472017053	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
504472017054	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
504472017055	FeS/SAM binding site; other site
504472017056	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
504472017057	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
504472017058	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
504472017059	ATP binding site [chemical binding]; other site
504472017060	substrate interface [chemical binding]; other site
504472017061	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472017062	active site residue [active]
504472017063	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
504472017064	active site
504472017065	thiamine phosphate binding site [chemical binding]; other site
504472017066	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
504472017067	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
504472017068	inhibitor-cofactor binding pocket; inhibition site
504472017069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
504472017070	catalytic residue [active]
504472017071	Histidine kinase; Region: His_kinase; pfam06580
504472017072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472017073	ATP binding site [chemical binding]; other site
504472017074	Mg2+ binding site [ion binding]; other site
504472017075	G-X-G motif; other site
504472017076	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472017077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017078	active site
504472017079	phosphorylation site [posttranslational modification]
504472017080	intermolecular recognition site; other site
504472017081	dimerization interface [polypeptide binding]; other site
504472017082	LytTr DNA-binding domain; Region: LytTR; smart00850
504472017083	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
504472017084	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
504472017085	putative dimerization interface [polypeptide binding]; other site
504472017086	putative ligand binding site [chemical binding]; other site
504472017087	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472017089	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
504472017090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
504472017091	putative substrate translocation pore; other site
504472017092	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
504472017093	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
504472017094	nucleotide binding site [chemical binding]; other site
504472017095	Putative carbohydrate binding domain; Region: CHB_HEX; cl03918
504472017096	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
504472017097	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
504472017098	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
504472017099	active site
504472017100	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
504472017101	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
504472017102	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
504472017103	Na binding site [ion binding]; other site
504472017104	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
504472017105	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
504472017106	inhibitor site; inhibition site
504472017107	active site
504472017108	dimer interface [polypeptide binding]; other site
504472017109	catalytic residue [active]
504472017110	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472017111	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472017112	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472017113	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472017114	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472017116	S-adenosylmethionine binding site [chemical binding]; other site
504472017117	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
504472017118	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
504472017119	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472017120	catalytic residues [active]
504472017121	PAS fold; Region: PAS_4; pfam08448
504472017122	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472017123	PAS fold; Region: PAS_4; pfam08448
504472017124	putative active site [active]
504472017125	heme pocket [chemical binding]; other site
504472017126	PAS domain; Region: PAS_9; pfam13426
504472017127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
504472017128	PAS fold; Region: PAS_3; pfam08447
504472017129	putative active site [active]
504472017130	heme pocket [chemical binding]; other site
504472017131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472017132	dimer interface [polypeptide binding]; other site
504472017133	phosphorylation site [posttranslational modification]
504472017134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472017135	ATP binding site [chemical binding]; other site
504472017136	Mg2+ binding site [ion binding]; other site
504472017137	G-X-G motif; other site
504472017138	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472017140	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
504472017141	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
504472017142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
504472017143	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
504472017144	active site
504472017145	metal binding site [ion binding]; metal-binding site
504472017146	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
504472017147	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
504472017148	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
504472017149	putative active site [active]
504472017150	catalytic site [active]
504472017151	putative metal binding site [ion binding]; other site
504472017152	oligomer interface [polypeptide binding]; other site
504472017153	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
504472017154	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
504472017155	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
504472017156	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
504472017157	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
504472017158	DNA binding residues [nucleotide binding]
504472017159	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472017160	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
504472017161	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472017162	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
504472017163	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472017164	starch binding outer membrane protein SusD; Region: SusD; cl17845
504472017165	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
504472017166	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142
504472017167	Peptidase family M48; Region: Peptidase_M48; cl12018
504472017168	MORN repeat; Region: MORN; cl14787
504472017169	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472017170	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472017171	active site
504472017172	catalytic tetrad [active]
504472017173	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
504472017174	Asp-box motif; other site
504472017175	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
504472017176	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
504472017177	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
504472017178	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
504472017179	DXD motif; other site
504472017180	cell surface protein SprA; Region: surface_SprA; TIGR04189
504472017181	Motility related/secretion protein; Region: SprA_N; pfam14349
504472017182	Motility related/secretion protein; Region: SprA_N; pfam14349
504472017183	Motility related/secretion protein; Region: SprA_N; pfam14349
504472017184	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
504472017185	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
504472017186	active site
504472017187	catalytic tetrad [active]
504472017188	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
504472017189	lipoyl attachment site [posttranslational modification]; other site
504472017190	dihydroorotase; Validated; Region: pyrC; PRK09357
504472017191	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
504472017192	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
504472017193	active site
504472017194	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
504472017195	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
504472017196	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
504472017197	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
504472017198	VanZ like family; Region: VanZ; cl01971
504472017199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472017200	binding surface
504472017201	TPR motif; other site
504472017202	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
504472017203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472017204	binding surface
504472017205	TPR motif; other site
504472017206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472017207	binding surface
504472017208	TPR motif; other site
504472017209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472017210	binding surface
504472017211	TPR motif; other site
504472017212	TPR repeat; Region: TPR_11; pfam13414
504472017213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
504472017214	binding surface
504472017215	TPR motif; other site
504472017216	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
504472017217	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
504472017218	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
504472017219	Fatty acid desaturase; Region: FA_desaturase; pfam00487
504472017220	putative di-iron ligands [ion binding]; other site
504472017221	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
504472017222	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
504472017223	active site
504472017224	substrate binding site [chemical binding]; other site
504472017225	Mg2+ binding site [ion binding]; other site
504472017226	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
504472017227	TPR repeat; Region: TPR_11; pfam13414
504472017228	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
504472017229	starch binding outer membrane protein SusD; Region: SusD; cd08977
504472017230	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472017231	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
504472017232	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
504472017233	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
504472017234	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
504472017235	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
504472017236	Transcriptional regulators [Transcription]; Region: PurR; COG1609
504472017237	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
504472017238	DNA binding site [nucleotide binding]
504472017239	domain linker motif; other site
504472017240	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
504472017241	ligand binding site [chemical binding]; other site
504472017242	dimerization interface [polypeptide binding]; other site
504472017243	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
504472017244	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
504472017245	active site
504472017246	substrate binding site [chemical binding]; other site
504472017247	coenzyme B12 binding site [chemical binding]; other site
504472017248	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
504472017249	B12 binding site [chemical binding]; other site
504472017250	cobalt ligand [ion binding]; other site
504472017251	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
504472017252	heterodimer interface [polypeptide binding]; other site
504472017253	substrate interaction site [chemical binding]; other site
504472017254	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
504472017255	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
504472017256	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472017258	motif II; other site
504472017259	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017260	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472017261	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
504472017262	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
504472017263	metal-binding site [ion binding]
504472017264	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017265	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472017266	motif II; other site
504472017267	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
504472017268	metal-binding site [ion binding]
504472017269	Domain of unknown function (DUF305); Region: DUF305; cl17794
504472017270	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
504472017271	Multicopper oxidase; Region: Cu-oxidase; pfam00394
504472017272	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
504472017273	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
504472017274	heme-binding residues [chemical binding]; other site
504472017275	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
504472017276	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
504472017277	FAD binding pocket [chemical binding]; other site
504472017278	FAD binding motif [chemical binding]; other site
504472017279	phosphate binding motif [ion binding]; other site
504472017280	beta-alpha-beta structure motif; other site
504472017281	NAD binding pocket [chemical binding]; other site
504472017282	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
504472017283	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472017284	catalytic loop [active]
504472017285	iron binding site [ion binding]; other site
504472017286	Domain of unknown function (DUF305); Region: DUF305; pfam03713
504472017287	Domain of unknown function (DUF305); Region: DUF305; pfam03713
504472017288	Initiator Replication protein; Region: Rep_3; pfam01051
504472017289	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
504472017290	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472017291	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
504472017292	active site
504472017293	Int/Topo IB signature motif; other site
504472017294	DNA binding site [nucleotide binding]
504472017295	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
504472017296	Histidine kinase; Region: His_kinase; pfam06580
504472017297	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472017298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017299	active site
504472017300	phosphorylation site [posttranslational modification]
504472017301	intermolecular recognition site; other site
504472017302	dimerization interface [polypeptide binding]; other site
504472017303	LytTr DNA-binding domain; Region: LytTR; smart00850
504472017304	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
504472017305	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
504472017306	Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565
504472017307	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
504472017308	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
504472017309	active site
504472017310	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
504472017311	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
504472017312	ligand binding site [chemical binding]; other site
504472017313	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
504472017314	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
504472017315	head completion protein; Provisional; Region: 4; PHA02552
504472017316	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
504472017317	DNA methylase; Region: N6_N4_Mtase; pfam01555
504472017318	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
504472017319	Part of AAA domain; Region: AAA_19; pfam13245
504472017320	Family description; Region: UvrD_C_2; pfam13538
504472017321	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
504472017322	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
504472017323	putative active site [active]
504472017324	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
504472017325	active site
504472017326	metal binding site [ion binding]; metal-binding site
504472017327	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
504472017328	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
504472017329	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
504472017330	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
504472017331	Peptidase family M23; Region: Peptidase_M23; pfam01551
504472017332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472017333	non-specific DNA binding site [nucleotide binding]; other site
504472017334	salt bridge; other site
504472017335	sequence-specific DNA binding site [nucleotide binding]; other site
504472017336	YWFCY protein; Region: YWFCY; pfam14293
504472017337	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
504472017338	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
504472017339	Walker B motif; other site
504472017340	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
504472017341	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
504472017342	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
504472017343	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472017344	P-loop; other site
504472017345	Magnesium ion binding site [ion binding]; other site
504472017346	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
504472017347	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
504472017348	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
504472017349	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
504472017350	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
504472017351	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
504472017352	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
504472017353	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
504472017354	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
504472017355	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
504472017356	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
504472017357	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
504472017358	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
504472017359	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
504472017360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472017361	S-adenosylmethionine binding site [chemical binding]; other site
504472017362	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
504472017363	DEAD-like helicases superfamily; Region: DEXDc; smart00487
504472017364	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
504472017365	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
504472017366	PIN domain; Region: PIN_3; pfam13470
504472017367	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
504472017368	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
504472017369	homotrimer interaction site [polypeptide binding]; other site
504472017370	putative active site [active]
504472017371	Predicted transcriptional regulator [Transcription]; Region: COG2378
504472017372	HTH domain; Region: HTH_11; pfam08279
504472017373	WYL domain; Region: WYL; pfam13280
504472017374	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472017375	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
504472017376	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472017377	N-terminal plug; other site
504472017378	ligand-binding site [chemical binding]; other site
504472017379	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
504472017380	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
504472017381	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472017382	active site
504472017383	Predicted membrane protein [Function unknown]; Region: COG2510
504472017384	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
504472017385	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
504472017386	active site
504472017387	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472017388	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472017389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017390	active site
504472017391	phosphorylation site [posttranslational modification]
504472017392	intermolecular recognition site; other site
504472017393	dimerization interface [polypeptide binding]; other site
504472017394	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472017395	DNA binding site [nucleotide binding]
504472017396	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472017397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472017398	dimer interface [polypeptide binding]; other site
504472017399	phosphorylation site [posttranslational modification]
504472017400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472017401	ATP binding site [chemical binding]; other site
504472017402	Mg2+ binding site [ion binding]; other site
504472017403	G-X-G motif; other site
504472017404	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
504472017405	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
504472017406	Cna protein B-type domain; Region: Cna_B_2; pfam13715
504472017407	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
504472017408	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472017409	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
504472017410	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
504472017411	MerT mercuric transport protein; Region: MerT; cl03578
504472017412	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
504472017413	metal-binding site [ion binding]
504472017414	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472017415	dimerization interface [polypeptide binding]; other site
504472017416	putative DNA binding site [nucleotide binding]; other site
504472017417	putative Zn2+ binding site [ion binding]; other site
504472017418	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
504472017419	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472017420	N-terminal plug; other site
504472017421	ligand-binding site [chemical binding]; other site
504472017422	NAD+ synthase (glutamine-hydrolysing); Region: PLN02339
504472017423	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
504472017424	multimer interface [polypeptide binding]; other site
504472017425	active site
504472017426	catalytic triad [active]
504472017427	protein interface 1 [polypeptide binding]; other site
504472017428	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
504472017429	homodimer interface [polypeptide binding]; other site
504472017430	NAD binding pocket [chemical binding]; other site
504472017431	ATP binding pocket [chemical binding]; other site
504472017432	Mg binding site [ion binding]; other site
504472017433	active-site loop [active]
504472017434	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
504472017435	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017436	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472017437	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
504472017438	Outer membrane efflux protein; Region: OEP; pfam02321
504472017439	Outer membrane efflux protein; Region: OEP; pfam02321
504472017440	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
504472017441	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
504472017442	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472017443	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017444	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472017445	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
504472017446	Integrase core domain; Region: rve; pfam00665
504472017447	Integrase core domain; Region: rve_3; pfam13683
504472017448	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
504472017449	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472017450	non-specific DNA binding site [nucleotide binding]; other site
504472017451	salt bridge; other site
504472017452	sequence-specific DNA binding site [nucleotide binding]; other site
504472017453	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
504472017454	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017455	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
504472017456	Transposase; Region: HTH_Tnp_1; pfam01527
504472017457	HTH-like domain; Region: HTH_21; pfam13276
504472017458	Integrase core domain; Region: rve; pfam00665
504472017459	DDE domain; Region: DDE_Tnp_IS240; pfam13610
504472017460	Integrase core domain; Region: rve_3; pfam13683
504472017461	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
504472017462	Transposase; Region: DDE_Tnp_ISL3; pfam01610
504472017463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
504472017464	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
504472017465	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
504472017466	Outer membrane efflux protein; Region: OEP; pfam02321
504472017467	Outer membrane efflux protein; Region: OEP; pfam02321
504472017468	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472017469	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017470	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
504472017471	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017472	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
504472017473	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
504472017474	Low affinity iron permease; Region: Iron_permease; pfam04120
504472017475	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
504472017476	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
504472017477	active site
504472017478	dimer interface [polypeptide binding]; other site
504472017479	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
504472017480	SdiA-regulated; Region: SdiA-regulated; cd09971
504472017481	putative active site [active]
504472017482	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
504472017483	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
504472017484	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017485	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
504472017486	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
504472017487	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
504472017488	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
504472017489	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
504472017490	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
504472017491	CAAX protease self-immunity; Region: Abi; pfam02517
504472017492	LytTr DNA-binding domain; Region: LytTR; smart00850
504472017493	transposase/IS protein; Provisional; Region: PRK09183
504472017494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472017495	Walker A motif; other site
504472017496	ATP binding site [chemical binding]; other site
504472017497	Walker B motif; other site
504472017498	arginine finger; other site
504472017499	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472017500	Integrase core domain; Region: rve; pfam00665
504472017501	DDE superfamily endonuclease; Region: DDE_5; cl17874
504472017502	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472017503	BNR repeat-like domain; Region: BNR_2; pfam13088
504472017504	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
504472017505	dimerization interface [polypeptide binding]; other site
504472017506	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
504472017507	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
504472017508	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
504472017509	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472017510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472017511	S-adenosylmethionine binding site [chemical binding]; other site
504472017512	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
504472017513	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
504472017514	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472017516	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
504472017517	metal-binding site [ion binding]
504472017518	Outer membrane efflux protein; Region: OEP; pfam02321
504472017519	Outer membrane efflux protein; Region: OEP; pfam02321
504472017520	HlyD family secretion protein; Region: HlyD_2; pfam12700
504472017521	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017522	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472017523	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472017524	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017525	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
504472017526	Protein of unknown function (DUF563); Region: DUF563; pfam04577
504472017527	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
504472017528	Domain of unknown function (DUF955); Region: DUF955; pfam06114
504472017529	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
504472017530	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
504472017531	active site
504472017532	catalytic site [active]
504472017533	substrate binding site [chemical binding]; other site
504472017534	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
504472017535	Toprim-like; Region: Toprim_2; pfam13155
504472017536	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
504472017537	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
504472017538	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
504472017539	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
504472017540	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
504472017541	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
504472017542	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
504472017543	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
504472017544	Methyltransferase domain; Region: Methyltransf_18; pfam12847
504472017545	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
504472017546	Catalytic site [active]
504472017547	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
504472017548	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
504472017549	active site
504472017550	DNA binding site [nucleotide binding]
504472017551	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
504472017552	Initiator Replication protein; Region: Rep_3; pfam01051
504472017553	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
504472017554	active site
504472017555	DNA binding site [nucleotide binding]
504472017556	Int/Topo IB signature motif; other site
504472017557	Helix-turn-helix domain; Region: HTH_19; pfam12844
504472017558	BNR repeat-like domain; Region: BNR_2; pfam13088
504472017559	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
504472017560	dimerization interface [polypeptide binding]; other site
504472017561	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
504472017562	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
504472017563	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
504472017564	Methyltransferase domain; Region: Methyltransf_31; pfam13847
504472017565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472017566	S-adenosylmethionine binding site [chemical binding]; other site
504472017567	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
504472017568	multicopper oxidase; Provisional; Region: PRK10965
504472017569	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
504472017570	Multicopper oxidase; Region: Cu-oxidase; pfam00394
504472017571	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
504472017572	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
504472017573	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472017575	Transposase; Region: DEDD_Tnp_IS110; pfam01548
504472017576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
504472017577	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
504472017578	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017579	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
504472017580	Outer membrane efflux protein; Region: OEP; pfam02321
504472017581	Outer membrane efflux protein; Region: OEP; pfam02321
504472017582	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017583	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472017584	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
504472017585	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017586	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
504472017587	Protein of unknown function (DUF563); Region: DUF563; pfam04577
504472017588	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
504472017589	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
504472017590	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
504472017591	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
504472017592	N-terminal plug; other site
504472017593	ligand-binding site [chemical binding]; other site
504472017594	Cupin domain; Region: Cupin_2; cl17218
504472017595	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
504472017596	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
504472017597	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
504472017598	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
504472017599	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
504472017600	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
504472017601	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017602	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
504472017603	motif II; other site
504472017604	Helix-turn-helix domain; Region: HTH_18; pfam12833
504472017605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
504472017606	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
504472017607	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
504472017608	metal-binding site [ion binding]
504472017609	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
504472017610	Soluble P-type ATPase [General function prediction only]; Region: COG4087
504472017611	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
504472017612	metal-binding site [ion binding]
504472017613	Domain of unknown function (DUF305); Region: DUF305; cl17794
504472017614	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
504472017615	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
504472017616	Multicopper oxidase; Region: Cu-oxidase; pfam00394
504472017617	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
504472017618	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
504472017619	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
504472017620	FAD binding pocket [chemical binding]; other site
504472017621	FAD binding motif [chemical binding]; other site
504472017622	phosphate binding motif [ion binding]; other site
504472017623	beta-alpha-beta structure motif; other site
504472017624	NAD binding pocket [chemical binding]; other site
504472017625	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
504472017626	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
504472017627	catalytic loop [active]
504472017628	iron binding site [ion binding]; other site
504472017629	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
504472017630	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
504472017631	acyl-activating enzyme (AAE) consensus motif; other site
504472017632	AMP binding site [chemical binding]; other site
504472017633	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
504472017634	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
504472017635	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
504472017636	active site
504472017637	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
504472017638	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
504472017639	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
504472017640	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
504472017641	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
504472017642	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
504472017643	catalytic residue [active]
504472017644	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
504472017645	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
504472017646	Domain of unknown function (DUF305); Region: DUF305; pfam03713
504472017647	Domain of unknown function (DUF305); Region: DUF305; cl17794
504472017648	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
504472017649	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
504472017650	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
504472017651	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472017652	P-loop; other site
504472017653	Magnesium ion binding site [ion binding]; other site
504472017654	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
504472017655	Domain of unknown function DUF87; Region: DUF87; pfam01935
504472017656	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
504472017657	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
504472017658	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
504472017659	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
504472017660	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
504472017661	ThiF family; Region: ThiF; pfam00899
504472017662	ATP binding site [chemical binding]; other site
504472017663	substrate interface [chemical binding]; other site
504472017664	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
504472017665	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
504472017666	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
504472017667	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
504472017668	ligand binding site [chemical binding]; other site
504472017669	flexible hinge region; other site
504472017670	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
504472017671	non-specific DNA interactions [nucleotide binding]; other site
504472017672	DNA binding site [nucleotide binding]
504472017673	sequence specific DNA binding site [nucleotide binding]; other site
504472017674	putative cAMP binding site [chemical binding]; other site
504472017675	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
504472017676	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
504472017677	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472017678	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
504472017679	active site residue [active]
504472017680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
504472017681	S-adenosylmethionine binding site [chemical binding]; other site
504472017682	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
504472017683	Predicted transporter component [General function prediction only]; Region: COG2391
504472017684	Sulphur transport; Region: Sulf_transp; pfam04143
504472017685	Predicted transporter component [General function prediction only]; Region: COG2391
504472017686	Sulphur transport; Region: Sulf_transp; pfam04143
504472017687	sulfite oxidase; Provisional; Region: PLN00177
504472017688	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
504472017689	Moco binding site; other site
504472017690	metal coordination site [ion binding]; other site
504472017691	dimerization interface [polypeptide binding]; other site
504472017692	Predicted membrane protein [Function unknown]; Region: COG2855
504472017693	Transcriptional regulator [Transcription]; Region: LysR; COG0583
504472017694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
504472017695	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
504472017696	putative dimerization interface [polypeptide binding]; other site
504472017697	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
504472017698	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
504472017699	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
504472017700	DsrE/DsrF-like family; Region: DrsE; cl00672
504472017701	Cytochrome c [Energy production and conversion]; Region: COG3258
504472017702	Cytochrome c; Region: Cytochrom_C; pfam00034
504472017703	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
504472017704	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
504472017705	Cupin domain; Region: Cupin_2; cl17218
504472017706	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
504472017707	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
504472017708	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
504472017709	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
504472017710	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
504472017711	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
504472017712	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
504472017713	HlyD family secretion protein; Region: HlyD_3; pfam13437
504472017714	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
504472017715	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
504472017716	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
504472017717	active site
504472017718	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472017719	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
504472017720	AAA domain; Region: AAA_14; pfam13173
504472017721	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
504472017722	putative DNA binding site [nucleotide binding]; other site
504472017723	putative Zn2+ binding site [ion binding]; other site
504472017724	Predicted membrane protein [Function unknown]; Region: COG2510
504472017725	Domain of unknown function (DUF305); Region: DUF305; cl17794
504472017726	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
504472017727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
504472017728	dimer interface [polypeptide binding]; other site
504472017729	phosphorylation site [posttranslational modification]
504472017730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
504472017731	ATP binding site [chemical binding]; other site
504472017732	Mg2+ binding site [ion binding]; other site
504472017733	G-X-G motif; other site
504472017734	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
504472017735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017736	active site
504472017737	phosphorylation site [posttranslational modification]
504472017738	intermolecular recognition site; other site
504472017739	dimerization interface [polypeptide binding]; other site
504472017740	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
504472017741	DNA binding site [nucleotide binding]
504472017742	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
504472017743	amphipathic channel; other site
504472017744	Asn-Pro-Ala signature motifs; other site
504472017745	enolase; Provisional; Region: eno; PRK00077
504472017746	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
504472017747	dimer interface [polypeptide binding]; other site
504472017748	metal binding site [ion binding]; metal-binding site
504472017749	substrate binding pocket [chemical binding]; other site
504472017750	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
504472017751	Ligand Binding Site [chemical binding]; other site
504472017752	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
504472017753	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
504472017754	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
504472017755	putative Cl- selectivity filter; other site
504472017756	putative pore gating glutamate residue; other site
504472017757	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
504472017758	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
504472017759	DNA binding site [nucleotide binding]
504472017760	dimer interface [polypeptide binding]; other site
504472017761	active site
504472017762	Int/Topo IB signature motif; other site
504472017763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
504472017764	transposase/IS protein; Provisional; Region: PRK09183
504472017765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
504472017766	Walker A motif; other site
504472017767	ATP binding site [chemical binding]; other site
504472017768	Walker B motif; other site
504472017769	arginine finger; other site
504472017770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
504472017771	Integrase core domain; Region: rve; pfam00665
504472017772	Histidine kinase; Region: His_kinase; pfam06580
504472017773	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
504472017774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017775	active site
504472017776	phosphorylation site [posttranslational modification]
504472017777	intermolecular recognition site; other site
504472017778	dimerization interface [polypeptide binding]; other site
504472017779	LytTr DNA-binding domain; Region: LytTR; smart00850
504472017780	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
504472017781	Transposase; Region: HTH_Tnp_1; cl17663
504472017782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
504472017783	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
504472017784	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
504472017785	putative active site [active]
504472017786	putative NTP binding site [chemical binding]; other site
504472017787	putative nucleic acid binding site [nucleotide binding]; other site
504472017788	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
504472017789	Integrase core domain; Region: rve; pfam00665
504472017790	Integrase core domain; Region: rve_3; pfam13683
504472017791	Leucine rich repeat; Region: LRR_8; pfam13855
504472017792	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
504472017793	Leucine rich repeat; Region: LRR_8; pfam13855
504472017794	Substrate binding site [chemical binding]; other site
504472017795	Leucine rich repeat; Region: LRR_8; pfam13855
504472017796	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
504472017797	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
504472017798	G1 box; other site
504472017799	GTP/Mg2+ binding site [chemical binding]; other site
504472017800	G2 box; other site
504472017801	Switch I region; other site
504472017802	G3 box; other site
504472017803	Switch II region; other site
504472017804	G4 box; other site
504472017805	G5 box; other site
504472017806	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
504472017807	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
504472017808	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
504472017809	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
504472017810	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
504472017811	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472017812	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
504472017813	Magnesium ion binding site [ion binding]; other site
504472017814	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
504472017815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
504472017816	non-specific DNA binding site [nucleotide binding]; other site
504472017817	salt bridge; other site
504472017818	sequence-specific DNA binding site [nucleotide binding]; other site
504472017819	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
504472017820	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
504472017821	CHC2 zinc finger; Region: zf-CHC2; cl17510
504472017822	Toprim-like; Region: Toprim_2; pfam13155
504472017823	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
504472017824	ParA-like protein; Provisional; Region: PHA02518
504472017825	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
504472017826	P-loop; other site
504472017827	Magnesium ion binding site [ion binding]; other site
504472017828	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
504472017829	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
504472017830	catalytic residues [active]
504472017831	catalytic nucleophile [active]
504472017832	Recombinase; Region: Recombinase; pfam07508
504472017833	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
504472017834	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
504472017835	catalytic residues [active]
504472017836	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
504472017837	Protein of unknown function (DUF3997); Region: DUF3997; pfam13162
504472017838	Initiator Replication protein; Region: Rep_3; pfam01051
504472017839	Protein of unknown function (DUF497); Region: DUF497; pfam04365
504472017840	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
504472017841	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
504472017842	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
504472017843	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
504472017844	active site
504472017845	tellurium resistance terB-like protein; Region: terB_like; cd07177
504472017846	metal binding site [ion binding]; metal-binding site
504472017847	MgtC family; Region: MgtC; pfam02308
504472017848	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
504472017849	Sensors of blue-light using FAD; Region: BLUF; pfam04940
504472017850	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
504472017851	Initiator Replication protein; Region: Rep_3; pfam01051
504472017852	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
504472017853	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
504472017854	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
504472017855	MgtC family; Region: MgtC; pfam02308
504472017856	tellurium resistance terB-like protein; Region: terB_like; cd07177
504472017857	metal binding site [ion binding]; metal-binding site
504472017858	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
504472017859	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
504472017860	active site
504472017861	Initiator Replication protein; Region: Rep_3; pfam01051
504472017862	Initiator Replication protein; Region: Rep_3; pfam01051
504472017863	Protein of unknown function (DUF497); Region: DUF497; pfam04365
504472017864	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
504472017865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017866	active site
504472017867	phosphorylation site [posttranslational modification]
504472017868	intermolecular recognition site; other site
504472017869	dimerization interface [polypeptide binding]; other site
504472017870	Response regulator receiver domain; Region: Response_reg; pfam00072
504472017871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017872	active site
504472017873	phosphorylation site [posttranslational modification]
504472017874	intermolecular recognition site; other site
504472017875	dimerization interface [polypeptide binding]; other site
504472017876	Response regulator receiver domain; Region: Response_reg; pfam00072
504472017877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
504472017878	active site
504472017879	phosphorylation site [posttranslational modification]
504472017880	intermolecular recognition site; other site
504472017881	dimerization interface [polypeptide binding]; other site
504472017882	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
504472017883	active site
504472017884	catalytic triad [active]
504472017885	oxyanion hole [active]
504472017886	Helix-turn-helix domain; Region: HTH_17; pfam12728
504472017887	Initiator Replication protein; Region: Rep_3; pfam01051
504472017888	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
504472017889	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
504472017890	hypothetical protein; Validated; Region: PRK09169