-- dump date 20140620_072917 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446470000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446470000003 Walker A motif; other site 446470000004 ATP binding site [chemical binding]; other site 446470000005 Walker B motif; other site 446470000006 arginine finger; other site 446470000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446470000008 DnaA box-binding interface [nucleotide binding]; other site 446470000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 446470000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446470000011 putative DNA binding surface [nucleotide binding]; other site 446470000012 dimer interface [polypeptide binding]; other site 446470000013 beta-clamp/clamp loader binding surface; other site 446470000014 beta-clamp/translesion DNA polymerase binding surface; other site 446470000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446470000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 446470000017 recombination protein F; Reviewed; Region: recF; PRK00064 446470000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 446470000019 Walker A/P-loop; other site 446470000020 ATP binding site [chemical binding]; other site 446470000021 Q-loop/lid; other site 446470000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470000023 ABC transporter signature motif; other site 446470000024 Walker B; other site 446470000025 D-loop; other site 446470000026 H-loop/switch region; other site 446470000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 446470000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446470000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470000030 ATP binding site [chemical binding]; other site 446470000031 Mg2+ binding site [ion binding]; other site 446470000032 G-X-G motif; other site 446470000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446470000034 anchoring element; other site 446470000035 dimer interface [polypeptide binding]; other site 446470000036 ATP binding site [chemical binding]; other site 446470000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 446470000038 active site 446470000039 putative metal-binding site [ion binding]; other site 446470000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446470000041 DNA gyrase subunit A; Validated; Region: PRK05560 446470000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446470000043 CAP-like domain; other site 446470000044 active site 446470000045 primary dimer interface [polypeptide binding]; other site 446470000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446470000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446470000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446470000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446470000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446470000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446470000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446470000053 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470000054 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470000055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470000056 Walker A/P-loop; other site 446470000057 ATP binding site [chemical binding]; other site 446470000058 Q-loop/lid; other site 446470000059 ABC transporter signature motif; other site 446470000060 Walker B; other site 446470000061 D-loop; other site 446470000062 H-loop/switch region; other site 446470000063 AAA ATPase domain; Region: AAA_16; pfam13191 446470000064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470000066 DNA binding residues [nucleotide binding] 446470000067 dimerization interface [polypeptide binding]; other site 446470000068 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 446470000069 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470000070 putative NAD(P) binding site [chemical binding]; other site 446470000071 Predicted flavoprotein [General function prediction only]; Region: COG0431 446470000072 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446470000073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470000075 putative substrate translocation pore; other site 446470000076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000077 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470000078 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470000079 DNA binding residues [nucleotide binding] 446470000080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470000081 classical (c) SDRs; Region: SDR_c; cd05233 446470000082 NAD(P) binding site [chemical binding]; other site 446470000083 active site 446470000084 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470000085 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470000086 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446470000087 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446470000088 Walker A/P-loop; other site 446470000089 ATP binding site [chemical binding]; other site 446470000090 Q-loop/lid; other site 446470000091 ABC transporter signature motif; other site 446470000092 Walker B; other site 446470000093 D-loop; other site 446470000094 H-loop/switch region; other site 446470000095 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446470000096 TrkA-N domain; Region: TrkA_N; pfam02254 446470000097 TrkA-C domain; Region: TrkA_C; pfam02080 446470000098 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470000099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470000100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470000101 non-specific DNA binding site [nucleotide binding]; other site 446470000102 salt bridge; other site 446470000103 sequence-specific DNA binding site [nucleotide binding]; other site 446470000104 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446470000105 active site 446470000106 catalytic residues [active] 446470000107 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446470000108 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470000109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470000110 active site 446470000111 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446470000112 DNA protecting protein DprA; Region: dprA; TIGR00732 446470000113 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 446470000114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000115 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446470000116 galactonate dehydratase; Provisional; Region: PRK14017 446470000117 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446470000118 metal binding site [ion binding]; metal-binding site 446470000119 substrate binding pocket [chemical binding]; other site 446470000120 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470000121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470000122 DNA-binding site [nucleotide binding]; DNA binding site 446470000123 FCD domain; Region: FCD; pfam07729 446470000124 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470000125 classical (c) SDRs; Region: SDR_c; cd05233 446470000126 NAD(P) binding site [chemical binding]; other site 446470000127 active site 446470000128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470000129 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470000130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470000131 dimer interface [polypeptide binding]; other site 446470000132 conserved gate region; other site 446470000133 putative PBP binding loops; other site 446470000134 ABC-ATPase subunit interface; other site 446470000135 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470000136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470000137 dimer interface [polypeptide binding]; other site 446470000138 conserved gate region; other site 446470000139 putative PBP binding loops; other site 446470000140 ABC-ATPase subunit interface; other site 446470000141 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446470000142 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446470000143 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446470000144 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446470000145 EF-hand domain pair; Region: EF_hand_5; pfam13499 446470000146 Ca2+ binding site [ion binding]; other site 446470000147 Methyltransferase domain; Region: Methyltransf_24; pfam13578 446470000148 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470000149 DinB superfamily; Region: DinB_2; pfam12867 446470000150 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470000151 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470000152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000154 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470000155 TIGR03086 family protein; Region: TIGR03086 446470000156 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 446470000157 putative hydrophobic ligand binding site [chemical binding]; other site 446470000158 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470000159 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470000160 catalytic site [active] 446470000161 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446470000162 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 446470000163 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 446470000164 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446470000165 dimer interface [polypeptide binding]; other site 446470000166 putative anticodon binding site; other site 446470000167 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470000168 motif 1; other site 446470000169 dimer interface [polypeptide binding]; other site 446470000170 active site 446470000171 motif 2; other site 446470000172 motif 3; other site 446470000173 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470000174 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470000175 NB-ARC domain; Region: NB-ARC; pfam00931 446470000176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470000177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470000178 binding surface 446470000179 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470000180 TPR motif; other site 446470000181 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470000182 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446470000183 4Fe-4S binding domain; Region: Fer4; pfam00037 446470000184 Cysteine-rich domain; Region: CCG; pfam02754 446470000185 Cysteine-rich domain; Region: CCG; pfam02754 446470000186 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 446470000187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470000188 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470000189 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446470000190 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 446470000191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446470000192 active site 446470000193 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470000194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470000195 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470000196 DNA binding residues [nucleotide binding] 446470000197 Predicted esterase [General function prediction only]; Region: COG0400 446470000198 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470000199 catalytic site [active] 446470000200 pantothenate kinase; Reviewed; Region: PRK13318 446470000201 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 446470000202 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 446470000203 dimerization interface [polypeptide binding]; other site 446470000204 active site 446470000205 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470000206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446470000207 L-aspartate oxidase; Provisional; Region: PRK07804 446470000208 L-aspartate oxidase; Provisional; Region: PRK06175 446470000209 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446470000210 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 446470000211 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 446470000212 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446470000213 tetramerization interface [polypeptide binding]; other site 446470000214 active site 446470000215 pantoate--beta-alanine ligase; Region: panC; TIGR00018 446470000216 Pantoate-beta-alanine ligase; Region: PanC; cd00560 446470000217 active site 446470000218 ATP-binding site [chemical binding]; other site 446470000219 pantoate-binding site; other site 446470000220 HXXH motif; other site 446470000221 Rossmann-like domain; Region: Rossmann-like; pfam10727 446470000222 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446470000223 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446470000224 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 446470000225 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 446470000226 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 446470000227 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 446470000228 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446470000229 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446470000230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000231 transcription termination factor Rho; Provisional; Region: PRK12678 446470000232 imidazolonepropionase; Provisional; Region: PRK14085 446470000233 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 446470000234 active site 446470000235 urocanate hydratase; Provisional; Region: PRK05414 446470000236 short chain dehydrogenase; Provisional; Region: PRK07791 446470000237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470000238 NAD(P) binding site [chemical binding]; other site 446470000239 active site 446470000240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000242 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446470000243 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446470000244 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446470000245 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446470000246 Uncharacterized conserved protein [Function unknown]; Region: COG3589 446470000247 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 446470000248 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 446470000249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470000250 substrate binding site [chemical binding]; other site 446470000251 oxyanion hole (OAH) forming residues; other site 446470000252 trimer interface [polypeptide binding]; other site 446470000253 Uncharacterized conserved protein [Function unknown]; Region: COG1262 446470000254 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446470000255 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446470000256 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470000257 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446470000258 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446470000259 oligomer interface [polypeptide binding]; other site 446470000260 metal binding site [ion binding]; metal-binding site 446470000261 metal binding site [ion binding]; metal-binding site 446470000262 putative Cl binding site [ion binding]; other site 446470000263 basic sphincter; other site 446470000264 hydrophobic gate; other site 446470000265 periplasmic entrance; other site 446470000266 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446470000267 nudix motif; other site 446470000268 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 446470000269 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446470000270 dimer interface [polypeptide binding]; other site 446470000271 active site 446470000272 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446470000273 active site 446470000274 catalytic triad [active] 446470000275 oxyanion hole [active] 446470000276 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446470000277 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446470000278 classical (c) SDRs; Region: SDR_c; cd05233 446470000279 NAD(P) binding site [chemical binding]; other site 446470000280 active site 446470000281 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 446470000282 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 446470000283 active site 446470000284 catalytic triad [active] 446470000285 dimer interface [polypeptide binding]; other site 446470000286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000288 WHG domain; Region: WHG; pfam13305 446470000289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000291 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446470000292 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446470000293 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446470000294 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446470000295 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 446470000296 active site 446470000297 catalytic residues [active] 446470000298 metal binding site [ion binding]; metal-binding site 446470000299 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 446470000300 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446470000301 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446470000302 dimer interface [polypeptide binding]; other site 446470000303 ssDNA binding site [nucleotide binding]; other site 446470000304 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446470000305 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 446470000306 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446470000307 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446470000308 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446470000309 replicative DNA helicase; Region: DnaB; TIGR00665 446470000310 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446470000311 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446470000312 Walker A motif; other site 446470000313 ATP binding site [chemical binding]; other site 446470000314 Walker B motif; other site 446470000315 DNA binding loops [nucleotide binding] 446470000316 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 446470000317 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 446470000318 homotrimer interaction site [polypeptide binding]; other site 446470000319 zinc binding site [ion binding]; other site 446470000320 CDP-binding sites; other site 446470000321 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 446470000322 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 446470000323 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 446470000324 malonyl-CoA binding site [chemical binding]; other site 446470000325 dimer interface [polypeptide binding]; other site 446470000326 active site 446470000327 product binding site; other site 446470000328 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446470000329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470000330 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446470000331 active site 446470000332 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 446470000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470000334 S-adenosylmethionine binding site [chemical binding]; other site 446470000335 UbiA prenyltransferase family; Region: UbiA; pfam01040 446470000336 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 446470000337 Protein of unknown function (DUF461); Region: DUF461; cl01071 446470000338 DNA repair protein RadA; Provisional; Region: PRK11823 446470000339 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446470000340 Walker A motif; other site 446470000341 ATP binding site [chemical binding]; other site 446470000342 Walker B motif; other site 446470000343 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446470000344 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470000345 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470000346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470000347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470000348 active site 446470000349 phosphorylation site [posttranslational modification] 446470000350 intermolecular recognition site; other site 446470000351 dimerization interface [polypeptide binding]; other site 446470000352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470000353 DNA binding site [nucleotide binding] 446470000354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470000355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470000356 dimerization interface [polypeptide binding]; other site 446470000357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470000358 dimer interface [polypeptide binding]; other site 446470000359 phosphorylation site [posttranslational modification] 446470000360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470000361 ATP binding site [chemical binding]; other site 446470000362 Mg2+ binding site [ion binding]; other site 446470000363 G-X-G motif; other site 446470000364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470000365 S-adenosylmethionine binding site [chemical binding]; other site 446470000366 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 446470000367 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 446470000368 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 446470000369 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470000370 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446470000371 short chain dehydrogenase; Provisional; Region: PRK06172 446470000372 classical (c) SDRs; Region: SDR_c; cd05233 446470000373 NAD(P) binding site [chemical binding]; other site 446470000374 active site 446470000375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000379 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 446470000380 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446470000381 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 446470000382 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 446470000383 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 446470000384 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470000385 Cytochrome P450; Region: p450; cl12078 446470000386 HTH domain; Region: HTH_11; cl17392 446470000387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470000388 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 446470000389 active site 446470000390 metal binding site [ion binding]; metal-binding site 446470000391 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 446470000392 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 446470000393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470000394 Walker A/P-loop; other site 446470000395 ATP binding site [chemical binding]; other site 446470000396 Q-loop/lid; other site 446470000397 ABC transporter signature motif; other site 446470000398 Walker B; other site 446470000399 D-loop; other site 446470000400 H-loop/switch region; other site 446470000401 TOBE domain; Region: TOBE_2; pfam08402 446470000402 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470000403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470000404 dimer interface [polypeptide binding]; other site 446470000405 conserved gate region; other site 446470000406 putative PBP binding loops; other site 446470000407 ABC-ATPase subunit interface; other site 446470000408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470000409 dimer interface [polypeptide binding]; other site 446470000410 conserved gate region; other site 446470000411 putative PBP binding loops; other site 446470000412 ABC-ATPase subunit interface; other site 446470000413 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470000414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470000415 nucleotide binding site [chemical binding]; other site 446470000416 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470000417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470000418 Histidine kinase; Region: HisKA_3; pfam07730 446470000419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470000421 active site 446470000422 phosphorylation site [posttranslational modification] 446470000423 intermolecular recognition site; other site 446470000424 dimerization interface [polypeptide binding]; other site 446470000425 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 446470000426 DNA binding residues [nucleotide binding] 446470000427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470000428 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446470000429 putative ADP-binding pocket [chemical binding]; other site 446470000430 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470000431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470000432 dimerization interface [polypeptide binding]; other site 446470000433 putative Zn2+ binding site [ion binding]; other site 446470000434 putative DNA binding site [nucleotide binding]; other site 446470000435 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 446470000436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470000437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470000438 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470000439 MarR family; Region: MarR_2; pfam12802 446470000440 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446470000441 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446470000442 acyl-activating enzyme (AAE) consensus motif; other site 446470000443 AMP binding site [chemical binding]; other site 446470000444 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470000445 Condensation domain; Region: Condensation; pfam00668 446470000446 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446470000447 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446470000448 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446470000449 acyl-activating enzyme (AAE) consensus motif; other site 446470000450 AMP binding site [chemical binding]; other site 446470000451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470000452 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470000453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000454 putative substrate translocation pore; other site 446470000455 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446470000456 Condensation domain; Region: Condensation; pfam00668 446470000457 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446470000458 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446470000459 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446470000460 acyl-activating enzyme (AAE) consensus motif; other site 446470000461 AMP binding site [chemical binding]; other site 446470000462 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470000463 Condensation domain; Region: Condensation; pfam00668 446470000464 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446470000465 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446470000466 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446470000467 acyl-activating enzyme (AAE) consensus motif; other site 446470000468 AMP binding site [chemical binding]; other site 446470000469 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470000470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470000471 S-adenosylmethionine binding site [chemical binding]; other site 446470000472 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470000473 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470000474 Condensation domain; Region: Condensation; pfam00668 446470000475 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446470000476 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470000477 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446470000478 active site 446470000479 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470000480 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470000481 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446470000482 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446470000483 tetramerization interface [polypeptide binding]; other site 446470000484 active site 446470000485 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470000486 DNA binding site [nucleotide binding] 446470000487 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470000488 NB-ARC domain; Region: NB-ARC; pfam00931 446470000489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470000490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446470000491 TPR motif; other site 446470000492 binding surface 446470000493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470000494 TPR motif; other site 446470000495 binding surface 446470000496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470000497 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 446470000498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 446470000499 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470000500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470000501 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470000502 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470000503 TIGR03086 family protein; Region: TIGR03086 446470000504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470000505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470000506 DNA binding site [nucleotide binding] 446470000507 domain linker motif; other site 446470000508 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470000509 dimerization interface [polypeptide binding]; other site 446470000510 ligand binding site [chemical binding]; other site 446470000511 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446470000512 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446470000513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470000514 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470000515 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446470000516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470000517 dimer interface [polypeptide binding]; other site 446470000518 conserved gate region; other site 446470000519 putative PBP binding loops; other site 446470000520 ABC-ATPase subunit interface; other site 446470000521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470000522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470000523 dimer interface [polypeptide binding]; other site 446470000524 conserved gate region; other site 446470000525 putative PBP binding loops; other site 446470000526 ABC-ATPase subunit interface; other site 446470000527 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 446470000528 putative substrate binding site [chemical binding]; other site 446470000529 active site 446470000530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470000531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470000532 DNA binding site [nucleotide binding] 446470000533 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000536 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 446470000537 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446470000538 putative NAD(P) binding site [chemical binding]; other site 446470000539 catalytic Zn binding site [ion binding]; other site 446470000540 structural Zn binding site [ion binding]; other site 446470000541 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446470000542 putative hydrophobic ligand binding site [chemical binding]; other site 446470000543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446470000544 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446470000545 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446470000546 acyl-CoA synthetase; Validated; Region: PRK07787 446470000547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470000548 acyl-activating enzyme (AAE) consensus motif; other site 446470000549 AMP binding site [chemical binding]; other site 446470000550 active site 446470000551 CoA binding site [chemical binding]; other site 446470000552 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 446470000553 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470000554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470000555 DNA-binding site [nucleotide binding]; DNA binding site 446470000556 FCD domain; Region: FCD; pfam07729 446470000557 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 446470000558 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446470000559 active site 446470000560 zinc binding site [ion binding]; other site 446470000561 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446470000562 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446470000563 oligomer interface [polypeptide binding]; other site 446470000564 active site residues [active] 446470000565 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446470000566 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446470000567 oligomer interface [polypeptide binding]; other site 446470000568 active site residues [active] 446470000569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470000570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470000571 non-specific DNA binding site [nucleotide binding]; other site 446470000572 salt bridge; other site 446470000573 sequence-specific DNA binding site [nucleotide binding]; other site 446470000574 AAA ATPase domain; Region: AAA_16; pfam13191 446470000575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470000577 DNA binding residues [nucleotide binding] 446470000578 dimerization interface [polypeptide binding]; other site 446470000579 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446470000580 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470000581 calcium binding site 2 [ion binding]; other site 446470000582 active site 446470000583 catalytic triad [active] 446470000584 calcium binding site 1 [ion binding]; other site 446470000585 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446470000586 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446470000587 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 446470000588 putative active site [active] 446470000589 catalytic site [active] 446470000590 putative metal binding site [ion binding]; other site 446470000591 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446470000592 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446470000593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470000594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470000595 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470000596 NAD(P) binding site [chemical binding]; other site 446470000597 active site 446470000598 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 446470000599 RibD C-terminal domain; Region: RibD_C; cl17279 446470000600 RibD C-terminal domain; Region: RibD_C; cl17279 446470000601 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 446470000602 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 446470000603 dimer interface [polypeptide binding]; other site 446470000604 active site 446470000605 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446470000606 folate binding site [chemical binding]; other site 446470000607 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446470000608 prephenate dehydrogenase; Validated; Region: PRK08507 446470000609 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446470000610 oligomerisation interface [polypeptide binding]; other site 446470000611 mobile loop; other site 446470000612 roof hairpin; other site 446470000613 Domain of unknown function DUF20; Region: UPF0118; pfam01594 446470000614 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446470000615 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446470000616 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446470000617 putative Mg++ binding site [ion binding]; other site 446470000618 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 446470000619 TIGR00153 family protein; Region: TIGR00153 446470000620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 446470000621 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470000622 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470000623 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446470000624 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 446470000625 active site 446470000626 intersubunit interface [polypeptide binding]; other site 446470000627 zinc binding site [ion binding]; other site 446470000628 Na+ binding site [ion binding]; other site 446470000629 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446470000630 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 446470000631 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 446470000632 putative dimer interface [polypeptide binding]; other site 446470000633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470000634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446470000635 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446470000636 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470000637 DNA binding residues [nucleotide binding] 446470000638 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470000639 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470000640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000642 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470000643 Isochorismatase family; Region: Isochorismatase; pfam00857 446470000644 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446470000645 catalytic triad [active] 446470000646 conserved cis-peptide bond; other site 446470000647 MarR family; Region: MarR_2; cl17246 446470000648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470000649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000651 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 446470000652 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 446470000653 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 446470000654 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446470000655 NAD binding site [chemical binding]; other site 446470000656 homotetramer interface [polypeptide binding]; other site 446470000657 homodimer interface [polypeptide binding]; other site 446470000658 active site 446470000659 substrate binding site [chemical binding]; other site 446470000660 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 446470000661 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 446470000662 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 446470000663 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 446470000664 NAD(P) binding site [chemical binding]; other site 446470000665 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470000666 hypothetical protein; Provisional; Region: PRK09946 446470000667 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 446470000668 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470000669 AAA ATPase domain; Region: AAA_16; pfam13191 446470000670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470000672 DNA binding residues [nucleotide binding] 446470000673 dimerization interface [polypeptide binding]; other site 446470000674 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446470000675 TQXA domain; Region: TQXA_dom; TIGR03934 446470000676 CAAX protease self-immunity; Region: Abi; pfam02517 446470000677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000678 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470000679 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470000680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470000681 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470000682 NAD(P) binding site [chemical binding]; other site 446470000683 active site 446470000684 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 446470000685 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470000686 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 446470000687 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470000688 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 446470000689 cyanate transporter; Region: CynX; TIGR00896 446470000690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000691 putative substrate translocation pore; other site 446470000692 Predicted transcriptional regulator [Transcription]; Region: COG1959 446470000693 Transcriptional regulator; Region: Rrf2; pfam02082 446470000694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000695 putative substrate translocation pore; other site 446470000696 Cupin domain; Region: Cupin_2; pfam07883 446470000697 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446470000698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470000699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470000700 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 446470000701 active site 446470000702 catalytic residues [active] 446470000703 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446470000704 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 446470000705 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 446470000706 active site 446470000707 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470000708 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446470000709 AsnC family; Region: AsnC_trans_reg; pfam01037 446470000710 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 446470000711 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 446470000712 dimer interface [polypeptide binding]; other site 446470000713 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 446470000714 active site 446470000715 Fe binding site [ion binding]; other site 446470000716 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 446470000717 RDD family; Region: RDD; pfam06271 446470000718 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 446470000719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470000720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470000721 homodimer interface [polypeptide binding]; other site 446470000722 catalytic residue [active] 446470000723 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446470000724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470000725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470000726 homodimer interface [polypeptide binding]; other site 446470000727 catalytic residue [active] 446470000728 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446470000729 active site 446470000730 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 446470000731 Rhomboid family; Region: Rhomboid; pfam01694 446470000732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470000733 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 446470000734 hypothetical protein; Provisional; Region: PRK07236 446470000735 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446470000736 active site 446470000737 FMN binding site [chemical binding]; other site 446470000738 substrate binding site [chemical binding]; other site 446470000739 homotetramer interface [polypeptide binding]; other site 446470000740 catalytic residue [active] 446470000741 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470000742 classical (c) SDRs; Region: SDR_c; cd05233 446470000743 NAD(P) binding site [chemical binding]; other site 446470000744 active site 446470000745 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 446470000746 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 446470000747 GTP binding site; other site 446470000748 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 446470000749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470000750 S-adenosylmethionine binding site [chemical binding]; other site 446470000751 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 446470000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470000753 S-adenosylmethionine binding site [chemical binding]; other site 446470000754 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 446470000755 catalytic site [active] 446470000756 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446470000757 nudix motif; other site 446470000758 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 446470000759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470000760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000761 putative substrate translocation pore; other site 446470000762 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470000763 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 446470000764 Lamin Tail Domain; Region: LTD; pfam00932 446470000765 Lamin Tail Domain; Region: LTD; pfam00932 446470000766 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 446470000767 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 446470000768 active site 446470000769 catalytic triad [active] 446470000770 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 446470000771 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446470000772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470000774 DNA binding residues [nucleotide binding] 446470000775 dimerization interface [polypeptide binding]; other site 446470000776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446470000777 non-specific DNA binding site [nucleotide binding]; other site 446470000778 salt bridge; other site 446470000779 sequence-specific DNA binding site [nucleotide binding]; other site 446470000780 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470000781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470000782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470000783 non-specific DNA binding site [nucleotide binding]; other site 446470000784 salt bridge; other site 446470000785 sequence-specific DNA binding site [nucleotide binding]; other site 446470000786 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 446470000787 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446470000788 nudix motif; other site 446470000789 Phosphotransferase enzyme family; Region: APH; pfam01636 446470000790 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470000791 active site 446470000792 ATP binding site [chemical binding]; other site 446470000793 substrate binding site [chemical binding]; other site 446470000794 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446470000795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470000796 motif II; other site 446470000797 Predicted transcriptional regulators [Transcription]; Region: COG1725 446470000798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470000799 DNA-binding site [nucleotide binding]; DNA binding site 446470000800 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470000801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470000802 metal binding site [ion binding]; metal-binding site 446470000803 active site 446470000804 I-site; other site 446470000805 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 446470000806 AAA-like domain; Region: AAA_10; pfam12846 446470000807 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446470000808 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 446470000809 Helix-turn-helix domain; Region: HTH_17; pfam12728 446470000810 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446470000811 active site 446470000812 catalytic residues [active] 446470000813 DNA binding site [nucleotide binding] 446470000814 Int/Topo IB signature motif; other site 446470000815 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470000816 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 446470000817 nucleotide binding site [chemical binding]; other site 446470000818 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470000819 SBD interface [polypeptide binding]; other site 446470000820 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446470000821 PQQ-like domain; Region: PQQ_2; pfam13360 446470000822 Trp docking motif [polypeptide binding]; other site 446470000823 active site 446470000824 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446470000825 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446470000826 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 446470000827 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446470000828 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470000829 active site 446470000830 HIGH motif; other site 446470000831 nucleotide binding site [chemical binding]; other site 446470000832 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446470000833 KMSKS motif; other site 446470000834 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446470000835 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446470000836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470000837 FeS/SAM binding site; other site 446470000838 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446470000839 Ubiquitin-like proteins; Region: UBQ; cl00155 446470000840 charged pocket; other site 446470000841 hydrophobic patch; other site 446470000842 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446470000843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470000844 Walker A motif; other site 446470000845 ATP binding site [chemical binding]; other site 446470000846 Walker B motif; other site 446470000847 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446470000848 Family description; Region: UvrD_C_2; pfam13538 446470000849 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470000850 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 446470000851 Clp amino terminal domain; Region: Clp_N; pfam02861 446470000852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470000853 Walker A motif; other site 446470000854 ATP binding site [chemical binding]; other site 446470000855 Walker B motif; other site 446470000856 Pleckstrin homology-like domain; Region: PH-like; cl17171 446470000857 chaperone protein DnaJ; Provisional; Region: PRK14279 446470000858 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446470000859 HSP70 interaction site [polypeptide binding]; other site 446470000860 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446470000861 Zn binding sites [ion binding]; other site 446470000862 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446470000863 dimer interface [polypeptide binding]; other site 446470000864 GrpE; Region: GrpE; pfam01025 446470000865 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 446470000866 dimer interface [polypeptide binding]; other site 446470000867 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446470000868 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446470000869 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 446470000870 nucleotide binding site [chemical binding]; other site 446470000871 NEF interaction site [polypeptide binding]; other site 446470000872 SBD interface [polypeptide binding]; other site 446470000873 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446470000874 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 446470000875 GDP-binding site [chemical binding]; other site 446470000876 ACT binding site; other site 446470000877 IMP binding site; other site 446470000878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470000879 DNA binding site [nucleotide binding] 446470000880 active site 446470000881 Int/Topo IB signature motif; other site 446470000882 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 446470000883 HD domain; Region: HD_3; pfam13023 446470000884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470000885 non-specific DNA binding site [nucleotide binding]; other site 446470000886 salt bridge; other site 446470000887 sequence-specific DNA binding site [nucleotide binding]; other site 446470000888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470000890 DNA binding residues [nucleotide binding] 446470000891 dimerization interface [polypeptide binding]; other site 446470000892 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446470000893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470000894 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446470000895 Walker A motif; other site 446470000896 ATP binding site [chemical binding]; other site 446470000897 Walker B motif; other site 446470000898 arginine finger; other site 446470000899 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446470000900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470000901 putative substrate translocation pore; other site 446470000902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470000903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000904 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470000905 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 446470000906 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 446470000907 Na binding site [ion binding]; other site 446470000908 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 446470000909 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446470000910 active site 446470000911 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 446470000912 putative active site [active] 446470000913 Zn binding site [ion binding]; other site 446470000914 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446470000915 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446470000916 Protein of unknown function (DUF690); Region: DUF690; cl04939 446470000917 Protein of unknown function (DUF2984); Region: DUF2984; pfam11203 446470000918 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446470000919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470000920 putative ADP-binding pocket [chemical binding]; other site 446470000921 translocation protein TolB; Provisional; Region: tolB; PRK05137 446470000922 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 446470000923 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446470000924 Cupin; Region: Cupin_6; pfam12852 446470000925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470000926 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470000927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470000928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470000929 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470000930 NAD(P) binding site [chemical binding]; other site 446470000931 active site 446470000932 hypothetical protein; Provisional; Region: PRK06834 446470000933 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470000934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470000935 Coenzyme A binding pocket [chemical binding]; other site 446470000936 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446470000937 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446470000938 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446470000939 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470000940 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446470000941 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470000942 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470000943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 446470000944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470000945 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446470000946 active site 446470000947 catalytic residues [active] 446470000948 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470000949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470000950 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470000951 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470000952 DNA binding site [nucleotide binding] 446470000953 domain linker motif; other site 446470000954 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470000955 dimerization interface [polypeptide binding]; other site 446470000956 ligand binding site [chemical binding]; other site 446470000957 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470000958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470000959 dimerization interface [polypeptide binding]; other site 446470000960 putative DNA binding site [nucleotide binding]; other site 446470000961 putative Zn2+ binding site [ion binding]; other site 446470000962 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 446470000963 Zn binding site [ion binding]; other site 446470000964 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470000965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 446470000966 dimerization interface [polypeptide binding]; other site 446470000967 DNA binding residues [nucleotide binding] 446470000968 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470000969 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470000970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470000971 Q-loop/lid; other site 446470000972 ABC transporter signature motif; other site 446470000973 Walker B; other site 446470000974 D-loop; other site 446470000975 H-loop/switch region; other site 446470000976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470000977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470000978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470000979 Walker A/P-loop; other site 446470000980 ATP binding site [chemical binding]; other site 446470000981 Q-loop/lid; other site 446470000982 ABC transporter signature motif; other site 446470000983 Walker B; other site 446470000984 D-loop; other site 446470000985 H-loop/switch region; other site 446470000986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470000987 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446470000988 Cupin; Region: Cupin_6; pfam12852 446470000989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470000990 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470000991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470000992 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446470000993 cleavage site 446470000994 active site 446470000995 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446470000996 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470000997 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470000998 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470000999 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470001000 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470001001 conserved cys residue [active] 446470001002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470001003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470001004 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470001005 DinB superfamily; Region: DinB_2; pfam12867 446470001006 Putative cyclase; Region: Cyclase; pfam04199 446470001007 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 446470001008 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 446470001009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470001010 Walker A motif; other site 446470001011 ATP binding site [chemical binding]; other site 446470001012 Walker B motif; other site 446470001013 arginine finger; other site 446470001014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470001015 Walker A motif; other site 446470001016 ATP binding site [chemical binding]; other site 446470001017 Walker B motif; other site 446470001018 arginine finger; other site 446470001019 Haemolysin-III related; Region: HlyIII; pfam03006 446470001020 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 446470001021 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470001022 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 446470001023 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446470001024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470001025 Walker A/P-loop; other site 446470001026 ATP binding site [chemical binding]; other site 446470001027 Q-loop/lid; other site 446470001028 ABC transporter signature motif; other site 446470001029 Walker B; other site 446470001030 D-loop; other site 446470001031 H-loop/switch region; other site 446470001032 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446470001033 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470001034 threonine synthase; Validated; Region: PRK07591 446470001035 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446470001036 homodimer interface [polypeptide binding]; other site 446470001037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470001038 catalytic residue [active] 446470001039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001040 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446470001041 TPR motif; other site 446470001042 TPR repeat; Region: TPR_11; pfam13414 446470001043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001044 TPR motif; other site 446470001045 binding surface 446470001046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001047 TPR motif; other site 446470001048 TPR repeat; Region: TPR_11; pfam13414 446470001049 binding surface 446470001050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001051 TPR motif; other site 446470001052 binding surface 446470001053 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 446470001054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470001055 ATP binding site [chemical binding]; other site 446470001056 Walker B motif; other site 446470001057 arginine finger; other site 446470001058 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 446470001059 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470001060 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470001061 Walker A/P-loop; other site 446470001062 ATP binding site [chemical binding]; other site 446470001063 Q-loop/lid; other site 446470001064 ABC transporter signature motif; other site 446470001065 Walker B; other site 446470001066 D-loop; other site 446470001067 H-loop/switch region; other site 446470001068 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 446470001069 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470001070 Walker A/P-loop; other site 446470001071 ATP binding site [chemical binding]; other site 446470001072 Q-loop/lid; other site 446470001073 ABC transporter signature motif; other site 446470001074 Walker B; other site 446470001075 D-loop; other site 446470001076 H-loop/switch region; other site 446470001077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470001078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470001079 active site 446470001080 ATP binding site [chemical binding]; other site 446470001081 substrate binding site [chemical binding]; other site 446470001082 activation loop (A-loop); other site 446470001083 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470001084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470001085 active site 446470001086 ATP binding site [chemical binding]; other site 446470001087 substrate binding site [chemical binding]; other site 446470001088 activation loop (A-loop); other site 446470001089 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 446470001090 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 446470001091 Int/Topo IB signature motif; other site 446470001092 NB-ARC domain; Region: NB-ARC; pfam00931 446470001093 hypothetical protein; Provisional; Region: PRK06851 446470001094 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470001095 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470001096 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470001097 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470001098 Predicted ATPase [General function prediction only]; Region: COG3903 446470001099 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470001100 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470001101 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470001102 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470001103 biotin synthase; Validated; Region: PRK06256 446470001104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470001105 FeS/SAM binding site; other site 446470001106 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 446470001107 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470001108 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 446470001109 inhibitor-cofactor binding pocket; inhibition site 446470001110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470001111 catalytic residue [active] 446470001112 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 446470001113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470001114 catalytic residue [active] 446470001115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470001116 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 446470001117 AAA domain; Region: AAA_26; pfam13500 446470001118 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470001119 Cytochrome P450; Region: p450; cl12078 446470001120 PRC-barrel domain; Region: PRC; pfam05239 446470001121 PE-PPE domain; Region: PE-PPE; pfam08237 446470001122 RNA polymerase III subunit RPC82 helix-turn-helix domain; Region: HTH_9; pfam08221 446470001123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001125 DNA binding residues [nucleotide binding] 446470001126 dimerization interface [polypeptide binding]; other site 446470001127 Family description; Region: VCBS; pfam13517 446470001128 Family description; Region: VCBS; pfam13517 446470001129 NAD-dependent deacetylase; Provisional; Region: PRK00481 446470001130 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446470001131 AAA-like domain; Region: AAA_10; pfam12846 446470001132 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 446470001133 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470001134 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470001135 Isochorismatase family; Region: Isochorismatase; pfam00857 446470001136 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446470001137 catalytic triad [active] 446470001138 conserved cis-peptide bond; other site 446470001139 2-isopropylmalate synthase; Validated; Region: PRK03739 446470001140 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446470001141 active site 446470001142 catalytic residues [active] 446470001143 metal binding site [ion binding]; metal-binding site 446470001144 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446470001145 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 446470001146 putative FMN binding site [chemical binding]; other site 446470001147 aspartate kinase; Reviewed; Region: PRK06635 446470001148 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 446470001149 putative catalytic residues [active] 446470001150 putative nucleotide binding site [chemical binding]; other site 446470001151 putative aspartate binding site [chemical binding]; other site 446470001152 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446470001153 putative allosteric regulatory site; other site 446470001154 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 446470001155 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446470001156 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446470001157 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446470001158 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 446470001159 active site 446470001160 interdomain interaction site; other site 446470001161 putative metal-binding site [ion binding]; other site 446470001162 nucleotide binding site [chemical binding]; other site 446470001163 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 446470001164 domain I; other site 446470001165 phosphate binding site [ion binding]; other site 446470001166 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 446470001167 domain II; other site 446470001168 domain III; other site 446470001169 nucleotide binding site [chemical binding]; other site 446470001170 DNA binding groove [nucleotide binding] 446470001171 catalytic site [active] 446470001172 domain IV; other site 446470001173 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446470001174 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446470001175 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 446470001176 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446470001177 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446470001178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446470001179 anti sigma factor interaction site; other site 446470001180 regulatory phosphorylation site [posttranslational modification]; other site 446470001181 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446470001182 FOG: CBS domain [General function prediction only]; Region: COG0517 446470001183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001185 active site 446470001186 phosphorylation site [posttranslational modification] 446470001187 intermolecular recognition site; other site 446470001188 dimerization interface [polypeptide binding]; other site 446470001189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001190 DNA binding residues [nucleotide binding] 446470001191 dimerization interface [polypeptide binding]; other site 446470001192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470001193 Histidine kinase; Region: HisKA_3; pfam07730 446470001194 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470001195 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470001196 Walker A/P-loop; other site 446470001197 ATP binding site [chemical binding]; other site 446470001198 Q-loop/lid; other site 446470001199 ABC transporter signature motif; other site 446470001200 Walker B; other site 446470001201 D-loop; other site 446470001202 H-loop/switch region; other site 446470001203 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446470001204 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446470001205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 446470001206 Walker A/P-loop; other site 446470001207 ATP binding site [chemical binding]; other site 446470001208 Q-loop/lid; other site 446470001209 ABC transporter signature motif; other site 446470001210 Walker B; other site 446470001211 D-loop; other site 446470001212 H-loop/switch region; other site 446470001213 ABC transporter; Region: ABC_tran_2; pfam12848 446470001214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446470001215 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470001216 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470001217 conserved cys residue [active] 446470001218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470001220 putative substrate translocation pore; other site 446470001221 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446470001222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470001223 Coenzyme A binding pocket [chemical binding]; other site 446470001224 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446470001225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470001226 ATP binding site [chemical binding]; other site 446470001227 putative Mg++ binding site [ion binding]; other site 446470001228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470001229 nucleotide binding region [chemical binding]; other site 446470001230 ATP-binding site [chemical binding]; other site 446470001231 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446470001232 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446470001233 iron-sulfur cluster [ion binding]; other site 446470001234 [2Fe-2S] cluster binding site [ion binding]; other site 446470001235 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 446470001236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470001237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470001238 DNA binding residues [nucleotide binding] 446470001239 Putative zinc-finger; Region: zf-HC2; pfam13490 446470001240 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 446470001241 putative catalytic site [active] 446470001242 putative metal binding site [ion binding]; other site 446470001243 putative phosphate binding site [ion binding]; other site 446470001244 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446470001245 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446470001246 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446470001247 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446470001248 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 446470001249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470001250 Walker A/P-loop; other site 446470001251 ATP binding site [chemical binding]; other site 446470001252 Q-loop/lid; other site 446470001253 ABC transporter signature motif; other site 446470001254 Walker B; other site 446470001255 D-loop; other site 446470001256 H-loop/switch region; other site 446470001257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470001258 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470001259 active site 446470001260 catalytic tetrad [active] 446470001261 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 446470001262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470001263 DNA binding residues [nucleotide binding] 446470001264 putative dimer interface [polypeptide binding]; other site 446470001265 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470001266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470001267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470001268 DNA binding residues [nucleotide binding] 446470001269 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470001270 Predicted membrane protein [Function unknown]; Region: COG3371 446470001271 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446470001272 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446470001273 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470001274 active site 446470001275 ATP binding site [chemical binding]; other site 446470001276 substrate binding site [chemical binding]; other site 446470001277 activation loop (A-loop); other site 446470001278 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446470001279 active site 446470001280 zinc binding site [ion binding]; other site 446470001281 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470001282 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470001283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470001284 Walker A/P-loop; other site 446470001285 ATP binding site [chemical binding]; other site 446470001286 Q-loop/lid; other site 446470001287 ABC transporter signature motif; other site 446470001288 Walker B; other site 446470001289 D-loop; other site 446470001290 H-loop/switch region; other site 446470001291 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446470001292 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446470001293 Walker A/P-loop; other site 446470001294 ATP binding site [chemical binding]; other site 446470001295 Q-loop/lid; other site 446470001296 ABC transporter signature motif; other site 446470001297 Walker B; other site 446470001298 D-loop; other site 446470001299 H-loop/switch region; other site 446470001300 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001302 DNA binding residues [nucleotide binding] 446470001303 dimerization interface [polypeptide binding]; other site 446470001304 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446470001305 Cna protein B-type domain; Region: Cna_B_2; pfam13715 446470001306 Kelch domain; Region: Kelch; smart00612 446470001307 Kelch motif; Region: Kelch_1; pfam01344 446470001308 Kelch motif; Region: Kelch_1; pfam01344 446470001309 acyl-CoA synthetase; Validated; Region: PRK06188 446470001310 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470001311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470001312 acyl-activating enzyme (AAE) consensus motif; other site 446470001313 acyl-activating enzyme (AAE) consensus motif; other site 446470001314 AMP binding site [chemical binding]; other site 446470001315 active site 446470001316 CoA binding site [chemical binding]; other site 446470001317 Right handed beta helix region; Region: Beta_helix; pfam13229 446470001318 Histidine kinase; Region: HisKA_3; pfam07730 446470001319 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470001320 Mg2+ binding site [ion binding]; other site 446470001321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001323 active site 446470001324 phosphorylation site [posttranslational modification] 446470001325 intermolecular recognition site; other site 446470001326 dimerization interface [polypeptide binding]; other site 446470001327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001328 DNA binding residues [nucleotide binding] 446470001329 dimerization interface [polypeptide binding]; other site 446470001330 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446470001331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470001332 S-adenosylmethionine binding site [chemical binding]; other site 446470001333 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470001334 Cytochrome P450; Region: p450; cl12078 446470001335 Domain of unknown function DUF11; Region: DUF11; pfam01345 446470001336 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 446470001337 Membrane protein of unknown function; Region: DUF360; pfam04020 446470001338 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470001339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470001340 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470001341 DNA binding residues [nucleotide binding] 446470001342 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 446470001343 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 446470001344 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 446470001345 dimer interface [polypeptide binding]; other site 446470001346 PYR/PP interface [polypeptide binding]; other site 446470001347 TPP binding site [chemical binding]; other site 446470001348 substrate binding site [chemical binding]; other site 446470001349 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 446470001350 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 446470001351 TPP-binding site [chemical binding]; other site 446470001352 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446470001353 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446470001354 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446470001355 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446470001356 dimer interface [polypeptide binding]; other site 446470001357 phosphoserine aminotransferase; Provisional; Region: PRK03080 446470001358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470001359 catalytic residue [active] 446470001360 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470001361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446470001362 alanine racemase; Reviewed; Region: alr; PRK00053 446470001363 active site 446470001364 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446470001365 dimer interface [polypeptide binding]; other site 446470001366 substrate binding site [chemical binding]; other site 446470001367 catalytic residues [active] 446470001368 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470001369 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470001370 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 446470001371 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 446470001372 Glycoprotease family; Region: Peptidase_M22; pfam00814 446470001373 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 446470001374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470001375 Coenzyme A binding pocket [chemical binding]; other site 446470001376 UGMP family protein; Validated; Region: PRK09604 446470001377 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 446470001378 YCII-related domain; Region: YCII; cl00999 446470001379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470001380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470001381 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446470001382 FAD binding domain; Region: FAD_binding_4; pfam01565 446470001383 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446470001384 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 446470001385 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 446470001386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470001387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470001388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470001389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470001390 putative substrate translocation pore; other site 446470001391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470001392 putative substrate translocation pore; other site 446470001393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470001394 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446470001395 catalytic core [active] 446470001396 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446470001397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470001398 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446470001399 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470001400 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446470001401 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470001402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470001403 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446470001404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 446470001405 dimer interface [polypeptide binding]; other site 446470001406 phosphorylation site [posttranslational modification] 446470001407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470001408 ATP binding site [chemical binding]; other site 446470001409 Mg2+ binding site [ion binding]; other site 446470001410 G-X-G motif; other site 446470001411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470001412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001413 active site 446470001414 phosphorylation site [posttranslational modification] 446470001415 intermolecular recognition site; other site 446470001416 dimerization interface [polypeptide binding]; other site 446470001417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470001418 DNA binding site [nucleotide binding] 446470001419 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 446470001420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470001421 Walker A/P-loop; other site 446470001422 ATP binding site [chemical binding]; other site 446470001423 Q-loop/lid; other site 446470001424 ABC transporter signature motif; other site 446470001425 Walker B; other site 446470001426 D-loop; other site 446470001427 H-loop/switch region; other site 446470001428 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446470001429 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446470001430 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446470001431 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470001432 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470001433 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 446470001434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470001435 FeS/SAM binding site; other site 446470001436 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 446470001437 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 446470001438 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446470001439 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446470001440 Walker A/P-loop; other site 446470001441 ATP binding site [chemical binding]; other site 446470001442 Q-loop/lid; other site 446470001443 ABC transporter signature motif; other site 446470001444 Walker B; other site 446470001445 D-loop; other site 446470001446 H-loop/switch region; other site 446470001447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470001448 dimer interface [polypeptide binding]; other site 446470001449 conserved gate region; other site 446470001450 putative PBP binding loops; other site 446470001451 ABC-ATPase subunit interface; other site 446470001452 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446470001453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446470001454 substrate binding pocket [chemical binding]; other site 446470001455 membrane-bound complex binding site; other site 446470001456 hinge residues; other site 446470001457 Yqey-like protein; Region: YqeY; cl17540 446470001458 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446470001459 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470001460 putative active site [active] 446470001461 putative metal binding site [ion binding]; other site 446470001462 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446470001463 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470001464 active site 446470001465 ATP binding site [chemical binding]; other site 446470001466 substrate binding site [chemical binding]; other site 446470001467 activation loop (A-loop); other site 446470001468 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 446470001469 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 446470001470 active site 446470001471 zinc binding site [ion binding]; other site 446470001472 hypothetical protein; Provisional; Region: PRK06834 446470001473 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470001474 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470001475 cleavage site 446470001476 active site 446470001477 substrate binding sites [chemical binding]; other site 446470001478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 446470001479 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470001480 AAA domain; Region: AAA_22; pfam13401 446470001481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470001482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001483 TPR motif; other site 446470001484 binding surface 446470001485 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470001486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470001487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470001488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470001489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470001490 active site 446470001491 catalytic tetrad [active] 446470001492 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446470001493 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 446470001494 CoA-ligase; Region: Ligase_CoA; pfam00549 446470001495 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446470001496 CoA binding domain; Region: CoA_binding; smart00881 446470001497 CoA-ligase; Region: Ligase_CoA; pfam00549 446470001498 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446470001499 Dimer interface [polypeptide binding]; other site 446470001500 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 446470001501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001503 active site 446470001504 phosphorylation site [posttranslational modification] 446470001505 intermolecular recognition site; other site 446470001506 dimerization interface [polypeptide binding]; other site 446470001507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001508 DNA binding residues [nucleotide binding] 446470001509 dimerization interface [polypeptide binding]; other site 446470001510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470001511 Histidine kinase; Region: HisKA_3; pfam07730 446470001512 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470001513 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470001514 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446470001515 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446470001516 active site 446470001517 substrate binding site [chemical binding]; other site 446470001518 cosubstrate binding site; other site 446470001519 catalytic site [active] 446470001520 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446470001521 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 446470001522 purine monophosphate binding site [chemical binding]; other site 446470001523 dimer interface [polypeptide binding]; other site 446470001524 putative catalytic residues [active] 446470001525 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 446470001526 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 446470001527 malate dehydrogenase; Reviewed; Region: PRK06223 446470001528 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 446470001529 NAD(P) binding site [chemical binding]; other site 446470001530 dimer interface [polypeptide binding]; other site 446470001531 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446470001532 substrate binding site [chemical binding]; other site 446470001533 YibE/F-like protein; Region: YibE_F; pfam07907 446470001534 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446470001535 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446470001536 substrate binding site [chemical binding]; other site 446470001537 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470001538 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470001539 Walker A/P-loop; other site 446470001540 ATP binding site [chemical binding]; other site 446470001541 Q-loop/lid; other site 446470001542 ABC transporter signature motif; other site 446470001543 Walker B; other site 446470001544 D-loop; other site 446470001545 H-loop/switch region; other site 446470001546 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470001547 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470001548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470001549 Walker A/P-loop; other site 446470001550 ATP binding site [chemical binding]; other site 446470001551 Q-loop/lid; other site 446470001552 ABC transporter signature motif; other site 446470001553 Walker B; other site 446470001554 D-loop; other site 446470001555 H-loop/switch region; other site 446470001556 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446470001557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470001558 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446470001559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470001560 dimer interface [polypeptide binding]; other site 446470001561 conserved gate region; other site 446470001562 putative PBP binding loops; other site 446470001563 ABC-ATPase subunit interface; other site 446470001564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470001565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470001566 dimer interface [polypeptide binding]; other site 446470001567 conserved gate region; other site 446470001568 putative PBP binding loops; other site 446470001569 ABC-ATPase subunit interface; other site 446470001570 Histidine kinase; Region: HisKA_3; pfam07730 446470001571 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470001572 Mg2+ binding site [ion binding]; other site 446470001573 CAAX protease self-immunity; Region: Abi; pfam02517 446470001574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001576 active site 446470001577 phosphorylation site [posttranslational modification] 446470001578 intermolecular recognition site; other site 446470001579 dimerization interface [polypeptide binding]; other site 446470001580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001581 DNA binding residues [nucleotide binding] 446470001582 dimerization interface [polypeptide binding]; other site 446470001583 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 446470001584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470001585 non-specific DNA binding site [nucleotide binding]; other site 446470001586 salt bridge; other site 446470001587 sequence-specific DNA binding site [nucleotide binding]; other site 446470001588 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 446470001589 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470001590 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470001591 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446470001592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470001593 Coenzyme A binding pocket [chemical binding]; other site 446470001594 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470001595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470001596 non-specific DNA binding site [nucleotide binding]; other site 446470001597 salt bridge; other site 446470001598 sequence-specific DNA binding site [nucleotide binding]; other site 446470001599 NB-ARC domain; Region: NB-ARC; pfam00931 446470001600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001601 TPR motif; other site 446470001602 binding surface 446470001603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001604 binding surface 446470001605 TPR repeat; Region: TPR_11; pfam13414 446470001606 TPR motif; other site 446470001607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470001608 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 446470001609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470001610 nucleotide binding site [chemical binding]; other site 446470001611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470001612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001613 active site 446470001614 phosphorylation site [posttranslational modification] 446470001615 intermolecular recognition site; other site 446470001616 dimerization interface [polypeptide binding]; other site 446470001617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470001618 DNA binding residues [nucleotide binding] 446470001619 dimerization interface [polypeptide binding]; other site 446470001620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470001621 Histidine kinase; Region: HisKA_3; pfam07730 446470001622 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470001623 ATP binding site [chemical binding]; other site 446470001624 Mg2+ binding site [ion binding]; other site 446470001625 G-X-G motif; other site 446470001626 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 446470001627 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 446470001628 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 446470001629 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 446470001630 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 446470001631 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446470001632 active site 446470001633 catalytic site [active] 446470001634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470001635 dimerization interface [polypeptide binding]; other site 446470001636 putative DNA binding site [nucleotide binding]; other site 446470001637 putative Zn2+ binding site [ion binding]; other site 446470001638 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 446470001639 putative hydrophobic ligand binding site [chemical binding]; other site 446470001640 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 446470001641 active site 446470001642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470001643 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 446470001644 substrate binding site [chemical binding]; other site 446470001645 dimer interface [polypeptide binding]; other site 446470001646 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470001647 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470001648 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446470001649 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470001650 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446470001651 Walker A/P-loop; other site 446470001652 ATP binding site [chemical binding]; other site 446470001653 Q-loop/lid; other site 446470001654 ABC transporter signature motif; other site 446470001655 Walker B; other site 446470001656 D-loop; other site 446470001657 H-loop/switch region; other site 446470001658 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470001659 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470001660 TM-ABC transporter signature motif; other site 446470001661 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 446470001662 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446470001663 putative ligand binding site [chemical binding]; other site 446470001664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446470001665 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 446470001666 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 446470001667 tetrameric interface [polypeptide binding]; other site 446470001668 NAD binding site [chemical binding]; other site 446470001669 catalytic residues [active] 446470001670 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 446470001671 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446470001672 PYR/PP interface [polypeptide binding]; other site 446470001673 dimer interface [polypeptide binding]; other site 446470001674 TPP binding site [chemical binding]; other site 446470001675 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446470001676 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 446470001677 TPP-binding site; other site 446470001678 KduI/IolB family; Region: KduI; pfam04962 446470001679 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446470001680 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470001681 substrate binding site [chemical binding]; other site 446470001682 ATP binding site [chemical binding]; other site 446470001683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470001684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470001685 DNA binding site [nucleotide binding] 446470001686 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470001687 ligand binding site [chemical binding]; other site 446470001688 dimerization interface [polypeptide binding]; other site 446470001689 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446470001690 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 446470001691 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 446470001692 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 446470001693 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470001694 Protein of unknown function (DUF690); Region: DUF690; cl04939 446470001695 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 446470001696 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446470001697 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446470001698 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470001699 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446470001700 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470001701 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470001702 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 446470001703 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 446470001704 active site 446470001705 catalytic residues [active] 446470001706 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470001707 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470001708 active site 446470001709 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446470001710 active site 446470001711 multimer interface [polypeptide binding]; other site 446470001712 anthranilate synthase; Provisional; Region: PRK13566 446470001713 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446470001714 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446470001715 glutamine binding [chemical binding]; other site 446470001716 catalytic triad [active] 446470001717 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470001718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470001719 TPR motif; other site 446470001720 binding surface 446470001721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470001722 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 446470001723 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446470001724 HIGH motif; other site 446470001725 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446470001726 active site 446470001727 KMSKS motif; other site 446470001728 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446470001729 tRNA binding surface [nucleotide binding]; other site 446470001730 anticodon binding site; other site 446470001731 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446470001732 active site 446470001733 catalytic residues [active] 446470001734 Protein of unknown function (DUF690); Region: DUF690; cl04939 446470001735 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 446470001736 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446470001737 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446470001738 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470001739 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446470001740 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470001741 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470001742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470001743 S-adenosylmethionine binding site [chemical binding]; other site 446470001744 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 446470001745 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 446470001746 active site 446470001747 metal binding site [ion binding]; metal-binding site 446470001748 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470001749 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 446470001750 enoyl-CoA hydratase; Provisional; Region: PRK08140 446470001751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470001752 substrate binding site [chemical binding]; other site 446470001753 oxyanion hole (OAH) forming residues; other site 446470001754 trimer interface [polypeptide binding]; other site 446470001755 PaaX-like protein; Region: PaaX; pfam07848 446470001756 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 446470001757 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 446470001758 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446470001759 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446470001760 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470001761 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446470001762 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446470001763 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470001764 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470001765 Domain of unknown function DUF59; Region: DUF59; pfam01883 446470001766 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 446470001767 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 446470001768 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446470001769 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 446470001770 domain interfaces; other site 446470001771 active site 446470001772 AMMECR1; Region: AMMECR1; cl00911 446470001773 Protein of unknown function, DUF393; Region: DUF393; pfam04134 446470001774 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446470001775 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446470001776 Bacterial PH domain; Region: DUF304; pfam03703 446470001777 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 446470001778 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 446470001779 transmembrane helices; other site 446470001780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470001781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470001782 active site 446470001783 phosphorylation site [posttranslational modification] 446470001784 intermolecular recognition site; other site 446470001785 dimerization interface [polypeptide binding]; other site 446470001786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470001787 DNA binding site [nucleotide binding] 446470001788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470001789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470001790 dimer interface [polypeptide binding]; other site 446470001791 phosphorylation site [posttranslational modification] 446470001792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470001793 ATP binding site [chemical binding]; other site 446470001794 Mg2+ binding site [ion binding]; other site 446470001795 G-X-G motif; other site 446470001796 hypothetical protein; Validated; Region: PRK00228 446470001797 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 446470001798 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 446470001799 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446470001800 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 446470001801 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446470001802 threonine dehydratase; Provisional; Region: PRK08198 446470001803 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 446470001804 tetramer interface [polypeptide binding]; other site 446470001805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470001806 catalytic residue [active] 446470001807 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 446470001808 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 446470001809 ligand binding site [chemical binding]; other site 446470001810 active site 446470001811 UGI interface [polypeptide binding]; other site 446470001812 catalytic site [active] 446470001813 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 446470001814 active site 446470001815 substrate-binding site [chemical binding]; other site 446470001816 metal-binding site [ion binding] 446470001817 GTP binding site [chemical binding]; other site 446470001818 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446470001819 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446470001820 catalytic residue [active] 446470001821 putative FPP diphosphate binding site; other site 446470001822 putative FPP binding hydrophobic cleft; other site 446470001823 dimer interface [polypeptide binding]; other site 446470001824 putative IPP diphosphate binding site; other site 446470001825 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446470001826 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446470001827 catalytic residue [active] 446470001828 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446470001829 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446470001830 catalytic residue [active] 446470001831 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 446470001832 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446470001833 putative active site [active] 446470001834 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446470001835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470001836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470001837 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446470001838 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446470001839 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446470001840 NAD(P) binding site [chemical binding]; other site 446470001841 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 446470001842 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446470001843 NAD(P) binding site [chemical binding]; other site 446470001844 catalytic residues [active] 446470001845 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446470001846 intersubunit interface [polypeptide binding]; other site 446470001847 active site 446470001848 catalytic residue [active] 446470001849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470001850 active site 446470001851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446470001852 active site 446470001853 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446470001854 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446470001855 LicD family; Region: LicD; pfam04991 446470001856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470001857 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470001858 putative acyl-acceptor binding pocket; other site 446470001859 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446470001860 active site 446470001861 catalytic triad [active] 446470001862 oxyanion hole [active] 446470001863 hypothetical protein; Provisional; Region: PRK08244 446470001864 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470001865 Uncharacterized conserved protein [Function unknown]; Region: COG3339 446470001866 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 446470001867 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470001868 nudix motif; other site 446470001869 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 446470001870 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446470001871 metal binding site [ion binding]; metal-binding site 446470001872 substrate binding pocket [chemical binding]; other site 446470001873 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 446470001874 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446470001875 catalytic residue [active] 446470001876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470001877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470001878 dimer interface [polypeptide binding]; other site 446470001879 conserved gate region; other site 446470001880 putative PBP binding loops; other site 446470001881 ABC-ATPase subunit interface; other site 446470001882 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446470001883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470001884 putative PBP binding loops; other site 446470001885 ABC-ATPase subunit interface; other site 446470001886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470001887 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470001888 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446470001889 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446470001890 Bacterial transcriptional regulator; Region: IclR; pfam01614 446470001891 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470001892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470001893 NAD(P) binding site [chemical binding]; other site 446470001894 active site 446470001895 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 446470001896 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470001897 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470001898 ligand binding site [chemical binding]; other site 446470001899 flexible hinge region; other site 446470001900 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446470001901 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446470001902 substrate binding pocket [chemical binding]; other site 446470001903 chain length determination region; other site 446470001904 substrate-Mg2+ binding site; other site 446470001905 catalytic residues [active] 446470001906 aspartate-rich region 1; other site 446470001907 active site lid residues [active] 446470001908 aspartate-rich region 2; other site 446470001909 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446470001910 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446470001911 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470001912 Peptidase M15; Region: Peptidase_M15_3; pfam08291 446470001913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470001914 MarR family; Region: MarR; pfam01047 446470001915 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446470001916 homotrimer interaction site [polypeptide binding]; other site 446470001917 putative active site [active] 446470001918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470001919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470001920 non-specific DNA binding site [nucleotide binding]; other site 446470001921 salt bridge; other site 446470001922 sequence-specific DNA binding site [nucleotide binding]; other site 446470001923 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470001924 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470001925 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 446470001926 putative NAD(P) binding site [chemical binding]; other site 446470001927 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 446470001928 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 446470001929 active site 446470001930 substrate binding site [chemical binding]; other site 446470001931 metal binding site [ion binding]; metal-binding site 446470001932 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470001933 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470001934 active site 446470001935 ATP binding site [chemical binding]; other site 446470001936 substrate binding site [chemical binding]; other site 446470001937 activation loop (A-loop); other site 446470001938 PsbP; Region: PsbP; cl03356 446470001939 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 446470001940 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446470001941 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446470001942 metal binding site [ion binding]; metal-binding site 446470001943 putative dimer interface [polypeptide binding]; other site 446470001944 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 446470001945 Zn binding site [ion binding]; other site 446470001946 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 446470001947 putative active site pocket [active] 446470001948 dimerization interface [polypeptide binding]; other site 446470001949 putative catalytic residue [active] 446470001950 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446470001951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470001952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470001953 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446470001954 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446470001955 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446470001956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446470001957 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446470001958 active site 446470001959 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446470001960 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446470001961 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 446470001962 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446470001963 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446470001964 carboxyltransferase (CT) interaction site; other site 446470001965 biotinylation site [posttranslational modification]; other site 446470001966 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 446470001967 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470001968 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470001969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470001970 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470001971 Walker A/P-loop; other site 446470001972 ATP binding site [chemical binding]; other site 446470001973 Q-loop/lid; other site 446470001974 ABC transporter signature motif; other site 446470001975 Walker B; other site 446470001976 D-loop; other site 446470001977 H-loop/switch region; other site 446470001978 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446470001979 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470001980 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446470001981 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470001982 Maf-like protein; Region: Maf; pfam02545 446470001983 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 446470001984 active site 446470001985 dimer interface [polypeptide binding]; other site 446470001986 Uncharacterized conserved protein [Function unknown]; Region: COG1432 446470001987 LabA_like proteins; Region: LabA_like; cd06167 446470001988 putative metal binding site [ion binding]; other site 446470001989 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446470001990 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446470001991 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446470001992 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446470001993 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 446470001994 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 446470001995 Predicted transcriptional regulators [Transcription]; Region: COG1378 446470001996 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 446470001997 Bacterial PH domain; Region: DUF304; pfam03703 446470001998 DNA binding site [nucleotide binding] 446470001999 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470002000 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470002001 AAA ATPase domain; Region: AAA_16; pfam13191 446470002002 NB-ARC domain; Region: NB-ARC; pfam00931 446470002003 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 446470002004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470002005 binding surface 446470002006 TPR motif; other site 446470002007 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470002008 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470002009 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470002011 TPR motif; other site 446470002012 binding surface 446470002013 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446470002014 Amidase; Region: Amidase; cl11426 446470002015 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 446470002016 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446470002017 active site 2 [active] 446470002018 active site 1 [active] 446470002019 Predicted membrane protein [Function unknown]; Region: COG2246 446470002020 GtrA-like protein; Region: GtrA; pfam04138 446470002021 Predicted membrane protein [Function unknown]; Region: COG2246 446470002022 GtrA-like protein; Region: GtrA; pfam04138 446470002023 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446470002024 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470002025 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470002026 DNA binding residues [nucleotide binding] 446470002027 Putative zinc-finger; Region: zf-HC2; pfam13490 446470002028 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446470002029 ATP-grasp domain; Region: ATP-grasp; pfam02222 446470002030 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 446470002031 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 446470002032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470002033 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470002034 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446470002035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446470002036 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 446470002037 dimer interface [polypeptide binding]; other site 446470002038 hexamer interface [polypeptide binding]; other site 446470002039 active site 2 [active] 446470002040 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470002041 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470002042 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446470002043 Walker A/P-loop; other site 446470002044 ATP binding site [chemical binding]; other site 446470002045 Q-loop/lid; other site 446470002046 ABC transporter signature motif; other site 446470002047 Walker B; other site 446470002048 D-loop; other site 446470002049 H-loop/switch region; other site 446470002050 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446470002051 active site 446470002052 ATP binding site [chemical binding]; other site 446470002053 substrate binding site [chemical binding]; other site 446470002054 activation loop (A-loop); other site 446470002055 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470002056 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470002057 structural tetrad; other site 446470002058 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470002059 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446470002060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470002061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470002062 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 446470002063 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446470002064 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446470002065 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470002066 catalytic residue [active] 446470002067 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470002068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470002069 putative DNA binding site [nucleotide binding]; other site 446470002070 putative Zn2+ binding site [ion binding]; other site 446470002071 AsnC family; Region: AsnC_trans_reg; pfam01037 446470002072 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446470002073 DNA binding residues [nucleotide binding] 446470002074 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 446470002075 Flavoprotein; Region: Flavoprotein; pfam02441 446470002076 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 446470002077 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 446470002078 prenyltransferase; Reviewed; Region: ubiA; PRK12888 446470002079 UbiA prenyltransferase family; Region: UbiA; pfam01040 446470002080 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 446470002081 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 446470002082 ResB-like family; Region: ResB; pfam05140 446470002083 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446470002084 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446470002085 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446470002086 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446470002087 catalytic residues [active] 446470002088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446470002089 catalytic core [active] 446470002090 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446470002091 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470002092 inhibitor-cofactor binding pocket; inhibition site 446470002093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470002094 catalytic residue [active] 446470002095 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446470002096 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446470002097 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 446470002098 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446470002099 Ligand Binding Site [chemical binding]; other site 446470002100 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470002101 MarR family; Region: MarR_2; cl17246 446470002102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470002103 active site 446470002104 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446470002105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470002106 Walker A motif; other site 446470002107 ATP binding site [chemical binding]; other site 446470002108 Walker B motif; other site 446470002109 arginine finger; other site 446470002110 Peptidase family M41; Region: Peptidase_M41; pfam01434 446470002111 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 446470002112 homodecamer interface [polypeptide binding]; other site 446470002113 GTP cyclohydrolase I; Provisional; Region: PLN03044 446470002114 active site 446470002115 putative catalytic site residues [active] 446470002116 zinc binding site [ion binding]; other site 446470002117 GTP-CH-I/GFRP interaction surface; other site 446470002118 Protein of unknown function (DUF419); Region: DUF419; pfam04237 446470002119 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446470002120 Class II fumarases; Region: Fumarase_classII; cd01362 446470002121 active site 446470002122 tetramer interface [polypeptide binding]; other site 446470002123 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 446470002124 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 446470002125 ABC1 family; Region: ABC1; pfam03109 446470002126 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470002127 active site 446470002128 ATP binding site [chemical binding]; other site 446470002129 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470002130 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446470002131 DNA polymerase III subunit delta'; Validated; Region: PRK08485 446470002132 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470002133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470002134 putative substrate translocation pore; other site 446470002135 thymidylate kinase; Validated; Region: tmk; PRK00698 446470002136 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 446470002137 TMP-binding site; other site 446470002138 ATP-binding site [chemical binding]; other site 446470002139 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446470002140 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 446470002141 dimer interface [polypeptide binding]; other site 446470002142 active site 446470002143 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446470002144 substrate binding site [chemical binding]; other site 446470002145 catalytic residue [active] 446470002146 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446470002147 active site 446470002148 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 446470002149 substrate binding site [chemical binding]; other site 446470002150 catalytic residues [active] 446470002151 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 446470002152 DNA binding site [nucleotide binding] 446470002153 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470002154 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470002155 AAA ATPase domain; Region: AAA_16; pfam13191 446470002156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470002157 binding surface 446470002158 TPR motif; other site 446470002159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002160 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 446470002161 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 446470002162 Walker A/P-loop; other site 446470002163 ATP binding site [chemical binding]; other site 446470002164 Q-loop/lid; other site 446470002165 ABC transporter signature motif; other site 446470002166 Walker B; other site 446470002167 D-loop; other site 446470002168 H-loop/switch region; other site 446470002169 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 446470002170 Permease; Region: Permease; pfam02405 446470002171 Permease; Region: Permease; pfam02405 446470002172 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 446470002173 mce related protein; Region: MCE; pfam02470 446470002174 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 446470002175 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 446470002176 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446470002177 active site 446470002178 catalytic site [active] 446470002179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446470002180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446470002181 substrate binding pocket [chemical binding]; other site 446470002182 membrane-bound complex binding site; other site 446470002183 hinge residues; other site 446470002184 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 446470002185 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 446470002186 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 446470002187 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 446470002188 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 446470002189 spermidine synthase; Provisional; Region: PRK03612 446470002190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470002191 BNR repeat-like domain; Region: BNR_2; pfam13088 446470002192 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470002193 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446470002194 DNA binding residues [nucleotide binding] 446470002195 dimer interface [polypeptide binding]; other site 446470002196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470002197 dimerization interface [polypeptide binding]; other site 446470002198 putative DNA binding site [nucleotide binding]; other site 446470002199 putative Zn2+ binding site [ion binding]; other site 446470002200 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 446470002201 active site triad [active] 446470002202 acetyl-CoA synthetase; Provisional; Region: PRK00174 446470002203 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 446470002204 active site 446470002205 CoA binding site [chemical binding]; other site 446470002206 acyl-activating enzyme (AAE) consensus motif; other site 446470002207 AMP binding site [chemical binding]; other site 446470002208 acetate binding site [chemical binding]; other site 446470002209 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446470002210 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470002211 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446470002212 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470002213 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002215 dimer interface [polypeptide binding]; other site 446470002216 conserved gate region; other site 446470002217 putative PBP binding loops; other site 446470002218 ABC-ATPase subunit interface; other site 446470002219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470002220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002221 dimer interface [polypeptide binding]; other site 446470002222 conserved gate region; other site 446470002223 putative PBP binding loops; other site 446470002224 ABC-ATPase subunit interface; other site 446470002225 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470002226 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470002227 putative NAD(P) binding site [chemical binding]; other site 446470002228 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470002229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470002230 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 446470002231 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 446470002232 FMN-binding pocket [chemical binding]; other site 446470002233 flavin binding motif; other site 446470002234 phosphate binding motif [ion binding]; other site 446470002235 beta-alpha-beta structure motif; other site 446470002236 NAD binding pocket [chemical binding]; other site 446470002237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446470002238 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 446470002239 catalytic loop [active] 446470002240 iron binding site [ion binding]; other site 446470002241 LicD family; Region: LicD; pfam04991 446470002242 LicD family; Region: LicD; pfam04991 446470002243 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 446470002244 active site 446470002245 metal-binding site 446470002246 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 446470002247 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446470002248 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 446470002249 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446470002250 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446470002251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470002252 NAD(P) binding site [chemical binding]; other site 446470002253 active site 446470002254 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 446470002255 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 446470002256 nucleotide binding site/active site [active] 446470002257 HIT family signature motif; other site 446470002258 catalytic residue [active] 446470002259 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446470002260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470002261 DNA-binding site [nucleotide binding]; DNA binding site 446470002262 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446470002263 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446470002264 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446470002265 active site 446470002266 HIGH motif; other site 446470002267 dimer interface [polypeptide binding]; other site 446470002268 KMSKS motif; other site 446470002269 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446470002270 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 446470002271 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 446470002272 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470002273 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470002274 AAA ATPase domain; Region: AAA_16; pfam13191 446470002275 NB-ARC domain; Region: NB-ARC; pfam00931 446470002276 TPR repeat; Region: TPR_11; pfam13414 446470002277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470002278 TPR motif; other site 446470002279 binding surface 446470002280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470002282 binding surface 446470002283 TPR motif; other site 446470002284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002285 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470002286 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470002287 AAA ATPase domain; Region: AAA_16; pfam13191 446470002288 NB-ARC domain; Region: NB-ARC; pfam00931 446470002289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470002291 binding surface 446470002292 TPR motif; other site 446470002293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002294 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002295 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446470002296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470002297 Walker A/P-loop; other site 446470002298 ATP binding site [chemical binding]; other site 446470002299 ABC transporter signature motif; other site 446470002300 Walker B; other site 446470002301 D-loop; other site 446470002302 H-loop/switch region; other site 446470002303 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 446470002304 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446470002305 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470002306 putative catalytic site [active] 446470002307 putative metal binding site [ion binding]; other site 446470002308 putative phosphate binding site [ion binding]; other site 446470002309 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470002310 putative catalytic site [active] 446470002311 putative metal binding site [ion binding]; other site 446470002312 putative phosphate binding site [ion binding]; other site 446470002313 Secretory lipase; Region: LIP; pfam03583 446470002314 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 446470002315 thiamine phosphate binding site [chemical binding]; other site 446470002316 active site 446470002317 pyrophosphate binding site [ion binding]; other site 446470002318 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446470002319 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 446470002320 thiS-thiF/thiG interaction site; other site 446470002321 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 446470002322 ThiS interaction site; other site 446470002323 putative active site [active] 446470002324 tetramer interface [polypeptide binding]; other site 446470002325 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446470002326 dimer interface [polypeptide binding]; other site 446470002327 substrate binding site [chemical binding]; other site 446470002328 ATP binding site [chemical binding]; other site 446470002329 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 446470002330 ThiC-associated domain; Region: ThiC-associated; pfam13667 446470002331 ThiC family; Region: ThiC; pfam01964 446470002332 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 446470002333 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 446470002334 Methyltransferase domain; Region: Methyltransf_12; pfam08242 446470002335 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 446470002336 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470002337 active site 446470002338 metal binding site [ion binding]; metal-binding site 446470002339 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446470002340 23S rRNA interface [nucleotide binding]; other site 446470002341 L3 interface [polypeptide binding]; other site 446470002342 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 446470002343 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446470002344 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 446470002345 active site 446470002346 substrate binding site [chemical binding]; other site 446470002347 metal binding site [ion binding]; metal-binding site 446470002348 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 446470002349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470002350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470002351 WHG domain; Region: WHG; pfam13305 446470002352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470002353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470002354 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 446470002355 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446470002356 Di-iron ligands [ion binding]; other site 446470002357 MarR family; Region: MarR_2; pfam12802 446470002358 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 446470002359 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470002360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470002361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470002362 DNA binding residues [nucleotide binding] 446470002363 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 446470002364 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446470002365 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446470002366 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 446470002367 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446470002368 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446470002369 tellurium resistance terB-like protein; Region: terB_like; cl11965 446470002370 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 446470002371 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446470002372 dimer interface [polypeptide binding]; other site 446470002373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470002374 catalytic residue [active] 446470002375 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 446470002376 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470002377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446470002378 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446470002379 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 446470002380 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 446470002381 Chain length determinant protein; Region: Wzz; cl15801 446470002382 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 446470002383 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 446470002384 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446470002385 active site 446470002386 catalytic triad [active] 446470002387 oxyanion hole [active] 446470002388 metabolite-proton symporter; Region: 2A0106; TIGR00883 446470002389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470002390 putative substrate translocation pore; other site 446470002391 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446470002392 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684 446470002393 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 446470002394 EamA-like transporter family; Region: EamA; pfam00892 446470002395 EamA-like transporter family; Region: EamA; pfam00892 446470002396 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 446470002397 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 446470002398 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446470002399 dimer interface [polypeptide binding]; other site 446470002400 active site 446470002401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470002402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470002403 NAD(P) binding site [chemical binding]; other site 446470002404 active site 446470002405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 446470002406 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 446470002407 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470002408 putative catalytic site [active] 446470002409 putative phosphate binding site [ion binding]; other site 446470002410 putative metal binding site [ion binding]; other site 446470002411 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446470002412 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470002413 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470002414 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470002415 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446470002416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470002417 DNA-binding site [nucleotide binding]; DNA binding site 446470002418 UTRA domain; Region: UTRA; pfam07702 446470002419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470002420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470002421 DNA binding residues [nucleotide binding] 446470002422 dimerization interface [polypeptide binding]; other site 446470002423 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470002424 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470002425 chaperone protein DnaJ; Provisional; Region: PRK14277 446470002426 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446470002427 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 446470002428 Helix-turn-helix domain; Region: HTH_17; cl17695 446470002429 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446470002430 active site 446470002431 catalytic residues [active] 446470002432 DNA binding site [nucleotide binding] 446470002433 Int/Topo IB signature motif; other site 446470002434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470002435 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470002436 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446470002437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470002438 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 446470002439 Protein of unknown function (DUF690); Region: DUF690; cl04939 446470002440 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 446470002441 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446470002442 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446470002443 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470002444 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446470002445 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470002446 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470002447 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446470002448 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470002449 DNA binding site [nucleotide binding] 446470002450 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470002451 NB-ARC domain; Region: NB-ARC; pfam00931 446470002452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470002453 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446470002454 active site 446470002455 catalytic residues [active] 446470002456 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446470002457 FAD binding domain; Region: FAD_binding_4; pfam01565 446470002458 Berberine and berberine like; Region: BBE; pfam08031 446470002459 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 446470002460 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470002461 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470002462 Walker A/P-loop; other site 446470002463 ATP binding site [chemical binding]; other site 446470002464 Q-loop/lid; other site 446470002465 ABC transporter signature motif; other site 446470002466 Walker B; other site 446470002467 D-loop; other site 446470002468 H-loop/switch region; other site 446470002469 Predicted transcriptional regulators [Transcription]; Region: COG1510 446470002470 MarR family; Region: MarR; pfam01047 446470002471 Influenza non-structural protein (NS2); Region: Flu_NS2; pfam00601 446470002472 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 446470002473 active site 446470002474 catalytic residues [active] 446470002475 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446470002476 active site 446470002477 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 446470002478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470002479 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446470002480 putative ADP-binding pocket [chemical binding]; other site 446470002481 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 446470002482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470002483 S-adenosylmethionine binding site [chemical binding]; other site 446470002484 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446470002485 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470002486 DNA binding residues [nucleotide binding] 446470002487 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 446470002488 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470002489 DNA binding residues [nucleotide binding] 446470002490 putative dimer interface [polypeptide binding]; other site 446470002491 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 446470002492 putative dimer interface [polypeptide binding]; other site 446470002493 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470002494 ligand binding site [chemical binding]; other site 446470002495 Zn binding site [ion binding]; other site 446470002496 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446470002497 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 446470002498 glutaminase active site [active] 446470002499 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446470002500 dimer interface [polypeptide binding]; other site 446470002501 active site 446470002502 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446470002503 dimer interface [polypeptide binding]; other site 446470002504 active site 446470002505 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 446470002506 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 446470002507 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 446470002508 putative substrate binding site [chemical binding]; other site 446470002509 putative ATP binding site [chemical binding]; other site 446470002510 citrate synthase 2; Provisional; Region: PRK12350 446470002511 Citrate synthase; Region: Citrate_synt; pfam00285 446470002512 oxalacetate binding site [chemical binding]; other site 446470002513 citrylCoA binding site [chemical binding]; other site 446470002514 coenzyme A binding site [chemical binding]; other site 446470002515 catalytic triad [active] 446470002516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446470002517 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446470002518 Probable transposase; Region: OrfB_IS605; pfam01385 446470002519 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446470002520 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446470002521 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446470002522 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446470002523 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446470002524 active site 446470002525 catalytic residues [active] 446470002526 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 446470002527 Domain of unknown function (DUF202); Region: DUF202; pfam02656 446470002528 Domain of unknown function (DUF202); Region: DUF202; cl09954 446470002529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470002530 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446470002531 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446470002532 Walker A/P-loop; other site 446470002533 ATP binding site [chemical binding]; other site 446470002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470002535 Q-loop/lid; other site 446470002536 ABC transporter signature motif; other site 446470002537 Walker B; other site 446470002538 D-loop; other site 446470002539 H-loop/switch region; other site 446470002540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470002541 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446470002542 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446470002543 Walker A/P-loop; other site 446470002544 ATP binding site [chemical binding]; other site 446470002545 Q-loop/lid; other site 446470002546 Walker B; other site 446470002547 D-loop; other site 446470002548 H-loop/switch region; other site 446470002549 CopC domain; Region: CopC; pfam04234 446470002550 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 446470002551 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446470002552 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446470002553 active site residue [active] 446470002554 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446470002555 active site residue [active] 446470002556 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 446470002557 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446470002558 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 446470002559 Walker A/P-loop; other site 446470002560 ATP binding site [chemical binding]; other site 446470002561 Q-loop/lid; other site 446470002562 ABC transporter signature motif; other site 446470002563 Walker B; other site 446470002564 D-loop; other site 446470002565 H-loop/switch region; other site 446470002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002567 dimer interface [polypeptide binding]; other site 446470002568 conserved gate region; other site 446470002569 ABC-ATPase subunit interface; other site 446470002570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002571 ABC-ATPase subunit interface; other site 446470002572 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 446470002573 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470002574 calcium binding site 2 [ion binding]; other site 446470002575 active site 446470002576 catalytic triad [active] 446470002577 calcium binding site 1 [ion binding]; other site 446470002578 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470002579 active site 446470002580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470002581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470002582 DNA binding site [nucleotide binding] 446470002583 domain linker motif; other site 446470002584 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470002585 dimerization interface [polypeptide binding]; other site 446470002586 ligand binding site [chemical binding]; other site 446470002587 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446470002588 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470002589 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470002590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002591 dimer interface [polypeptide binding]; other site 446470002592 conserved gate region; other site 446470002593 putative PBP binding loops; other site 446470002594 ABC-ATPase subunit interface; other site 446470002595 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470002596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002597 dimer interface [polypeptide binding]; other site 446470002598 conserved gate region; other site 446470002599 putative PBP binding loops; other site 446470002600 ABC-ATPase subunit interface; other site 446470002601 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446470002602 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446470002603 Walker A/P-loop; other site 446470002604 ATP binding site [chemical binding]; other site 446470002605 Q-loop/lid; other site 446470002606 ABC transporter signature motif; other site 446470002607 Walker B; other site 446470002608 D-loop; other site 446470002609 H-loop/switch region; other site 446470002610 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470002611 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470002612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470002613 DNA binding residues [nucleotide binding] 446470002614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470002615 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470002616 DinB superfamily; Region: DinB_2; pfam12867 446470002617 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446470002618 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 446470002619 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 446470002620 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446470002621 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446470002622 GAF domain; Region: GAF; cl17456 446470002623 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446470002624 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446470002625 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446470002626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446470002627 dimerization interface [polypeptide binding]; other site 446470002628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002629 dimerization interface [polypeptide binding]; other site 446470002630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002631 dimerization interface [polypeptide binding]; other site 446470002632 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446470002633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002634 dimerization interface [polypeptide binding]; other site 446470002635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002636 dimerization interface [polypeptide binding]; other site 446470002637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002638 dimerization interface [polypeptide binding]; other site 446470002639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002640 dimerization interface [polypeptide binding]; other site 446470002641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470002642 dimerization interface [polypeptide binding]; other site 446470002643 GAF domain; Region: GAF_2; pfam13185 446470002644 GAF domain; Region: GAF; pfam01590 446470002645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470002646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470002647 ATP binding site [chemical binding]; other site 446470002648 Mg2+ binding site [ion binding]; other site 446470002649 G-X-G motif; other site 446470002650 Response regulator receiver domain; Region: Response_reg; pfam00072 446470002651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470002652 active site 446470002653 phosphorylation site [posttranslational modification] 446470002654 intermolecular recognition site; other site 446470002655 dimerization interface [polypeptide binding]; other site 446470002656 Response regulator receiver domain; Region: Response_reg; pfam00072 446470002657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470002658 active site 446470002659 phosphorylation site [posttranslational modification] 446470002660 intermolecular recognition site; other site 446470002661 dimerization interface [polypeptide binding]; other site 446470002662 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446470002663 anti sigma factor interaction site; other site 446470002664 regulatory phosphorylation site [posttranslational modification]; other site 446470002665 Transglycosylase; Region: Transgly; pfam00912 446470002666 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446470002667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446470002668 Transcription factor WhiB; Region: Whib; pfam02467 446470002669 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 446470002670 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446470002671 DTAP/Switch II; other site 446470002672 Switch I; other site 446470002673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446470002674 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 446470002675 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446470002676 DTAP/Switch II; other site 446470002677 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 446470002678 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446470002679 homotrimer interaction site [polypeptide binding]; other site 446470002680 putative active site [active] 446470002681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470002682 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 446470002683 Double zinc ribbon; Region: DZR; pfam12773 446470002684 cyclase homology domain; Region: CHD; cd07302 446470002685 nucleotidyl binding site; other site 446470002686 metal binding site [ion binding]; metal-binding site 446470002687 dimer interface [polypeptide binding]; other site 446470002688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470002689 Walker A motif; other site 446470002690 ATP binding site [chemical binding]; other site 446470002691 Walker B motif; other site 446470002692 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470002693 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470002694 active site 446470002695 ATP binding site [chemical binding]; other site 446470002696 substrate binding site [chemical binding]; other site 446470002697 activation loop (A-loop); other site 446470002698 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470002699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470002700 ligand binding site [chemical binding]; other site 446470002701 flexible hinge region; other site 446470002702 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446470002703 non-specific DNA interactions [nucleotide binding]; other site 446470002704 DNA binding site [nucleotide binding] 446470002705 sequence specific DNA binding site [nucleotide binding]; other site 446470002706 putative cAMP binding site [chemical binding]; other site 446470002707 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 446470002708 Colicin V production protein; Region: Colicin_V; pfam02674 446470002709 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446470002710 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470002711 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446470002712 putative active site [active] 446470002713 putative CoA binding site [chemical binding]; other site 446470002714 nudix motif; other site 446470002715 metal binding site [ion binding]; metal-binding site 446470002716 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446470002717 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446470002718 catalytic residues [active] 446470002719 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446470002720 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446470002721 minor groove reading motif; other site 446470002722 helix-hairpin-helix signature motif; other site 446470002723 substrate binding pocket [chemical binding]; other site 446470002724 active site 446470002725 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 446470002726 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470002727 Cytochrome P450; Region: p450; cl12078 446470002728 Helix-turn-helix domain; Region: HTH_38; pfam13936 446470002729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470002730 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470002731 Protein of unknown function (DUF993); Region: DUF993; pfam06187 446470002732 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446470002733 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446470002734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470002735 DNA-binding site [nucleotide binding]; DNA binding site 446470002736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470002737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470002738 homodimer interface [polypeptide binding]; other site 446470002739 catalytic residue [active] 446470002740 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 446470002741 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446470002742 oligomerisation interface [polypeptide binding]; other site 446470002743 mobile loop; other site 446470002744 roof hairpin; other site 446470002745 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446470002746 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446470002747 ring oligomerisation interface [polypeptide binding]; other site 446470002748 ATP/Mg binding site [chemical binding]; other site 446470002749 stacking interactions; other site 446470002750 hinge regions; other site 446470002751 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470002752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470002753 DNA binding residues [nucleotide binding] 446470002754 dimerization interface [polypeptide binding]; other site 446470002755 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446470002756 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446470002757 PA14 domain; Region: PA14; cl08459 446470002758 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446470002759 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446470002760 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 446470002761 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446470002762 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446470002763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 446470002764 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446470002765 active site 446470002766 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446470002767 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446470002768 phosphate binding site [ion binding]; other site 446470002769 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446470002770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470002771 S-adenosylmethionine binding site [chemical binding]; other site 446470002772 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470002773 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470002774 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446470002775 GMP synthase; Reviewed; Region: guaA; PRK00074 446470002776 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446470002777 AMP/PPi binding site [chemical binding]; other site 446470002778 candidate oxyanion hole; other site 446470002779 catalytic triad [active] 446470002780 potential glutamine specificity residues [chemical binding]; other site 446470002781 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446470002782 ATP Binding subdomain [chemical binding]; other site 446470002783 Ligand Binding sites [chemical binding]; other site 446470002784 Dimerization subdomain; other site 446470002785 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446470002786 nudix motif; other site 446470002787 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470002788 nudix motif; other site 446470002789 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 446470002790 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446470002791 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 446470002792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446470002793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002794 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446470002795 dimer interface [polypeptide binding]; other site 446470002796 conserved gate region; other site 446470002797 putative PBP binding loops; other site 446470002798 ABC-ATPase subunit interface; other site 446470002799 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 446470002800 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446470002801 minor groove reading motif; other site 446470002802 helix-hairpin-helix signature motif; other site 446470002803 active site 446470002804 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 446470002805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470002806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470002807 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470002808 putative dimerization interface [polypeptide binding]; other site 446470002809 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 446470002810 EamA-like transporter family; Region: EamA; pfam00892 446470002811 EamA-like transporter family; Region: EamA; pfam00892 446470002812 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470002813 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446470002814 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446470002815 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446470002816 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446470002817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470002818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470002819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446470002820 dimerization interface [polypeptide binding]; other site 446470002821 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 446470002822 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470002823 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470002824 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470002825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470002826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470002827 DNA binding residues [nucleotide binding] 446470002828 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470002829 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470002830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 446470002831 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470002832 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470002833 putative acyl-acceptor binding pocket; other site 446470002834 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470002835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470002836 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470002837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470002838 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470002839 TM-ABC transporter signature motif; other site 446470002840 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446470002841 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446470002842 Walker A/P-loop; other site 446470002843 ATP binding site [chemical binding]; other site 446470002844 Q-loop/lid; other site 446470002845 ABC transporter signature motif; other site 446470002846 Walker B; other site 446470002847 D-loop; other site 446470002848 H-loop/switch region; other site 446470002849 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446470002850 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446470002851 putative ligand binding site [chemical binding]; other site 446470002852 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 446470002853 substrate binding pocket [chemical binding]; other site 446470002854 substrate-Mg2+ binding site; other site 446470002855 aspartate-rich region 1; other site 446470002856 active site lid residues [active] 446470002857 aspartate-rich region 2; other site 446470002858 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 446470002859 substrate binding pocket [chemical binding]; other site 446470002860 substrate-Mg2+ binding site; other site 446470002861 aspartate-rich region 1; other site 446470002862 active site lid residues [active] 446470002863 aspartate-rich region 2; other site 446470002864 Protein of unknown function (DUF419); Region: DUF419; pfam04237 446470002865 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446470002866 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446470002867 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446470002868 active site 446470002869 catalytic site [active] 446470002870 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446470002871 active site 446470002872 NTP binding site [chemical binding]; other site 446470002873 metal binding triad [ion binding]; metal-binding site 446470002874 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 446470002875 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 446470002876 putative active site [active] 446470002877 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 446470002878 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 446470002879 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470002880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446470002881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470002883 dimer interface [polypeptide binding]; other site 446470002884 conserved gate region; other site 446470002885 ABC-ATPase subunit interface; other site 446470002886 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470002887 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470002888 Walker A/P-loop; other site 446470002889 ATP binding site [chemical binding]; other site 446470002890 Q-loop/lid; other site 446470002891 ABC transporter signature motif; other site 446470002892 Walker B; other site 446470002893 D-loop; other site 446470002894 H-loop/switch region; other site 446470002895 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470002896 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470002897 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470002898 Walker A/P-loop; other site 446470002899 ATP binding site [chemical binding]; other site 446470002900 Q-loop/lid; other site 446470002901 ABC transporter signature motif; other site 446470002902 Walker B; other site 446470002903 D-loop; other site 446470002904 H-loop/switch region; other site 446470002905 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470002906 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446470002907 substrate binding site [chemical binding]; other site 446470002908 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446470002909 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446470002910 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446470002911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470002913 ATP binding site [chemical binding]; other site 446470002914 Mg2+ binding site [ion binding]; other site 446470002915 G-X-G motif; other site 446470002916 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446470002917 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446470002918 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446470002919 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446470002920 G2 box; other site 446470002921 Switch I region; other site 446470002922 G3 box; other site 446470002923 Switch II region; other site 446470002924 GTP/Mg2+ binding site [chemical binding]; other site 446470002925 G4 box; other site 446470002926 G5 box; other site 446470002927 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446470002928 GAF domain; Region: GAF; pfam01590 446470002929 FAD binding domain; Region: FAD_binding_3; pfam01494 446470002930 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 446470002931 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446470002932 acyl-activating enzyme (AAE) consensus motif; other site 446470002933 AMP binding site [chemical binding]; other site 446470002934 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470002935 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446470002936 active site 446470002937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470002938 AAA ATPase domain; Region: AAA_16; pfam13191 446470002939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470002940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470002941 DNA binding residues [nucleotide binding] 446470002942 dimerization interface [polypeptide binding]; other site 446470002943 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446470002944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470002945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470002946 phosphoenolpyruvate synthase; Validated; Region: PRK06241 446470002947 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446470002948 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446470002949 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 446470002950 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446470002951 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470002952 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470002953 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 446470002954 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 446470002955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446470002956 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 446470002957 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470002958 putative substrate binding site [chemical binding]; other site 446470002959 putative ATP binding site [chemical binding]; other site 446470002960 FAD dependent oxidoreductase; Region: DAO; pfam01266 446470002961 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446470002962 mce related protein; Region: MCE; pfam02470 446470002963 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446470002964 mce related protein; Region: MCE; pfam02470 446470002965 mce related protein; Region: MCE; pfam02470 446470002966 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446470002967 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446470002968 mce related protein; Region: MCE; pfam02470 446470002969 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 446470002970 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446470002971 mce related protein; Region: MCE; pfam02470 446470002972 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446470002973 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 446470002974 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446470002975 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446470002976 RPB10 interaction site [polypeptide binding]; other site 446470002977 RPB1 interaction site [polypeptide binding]; other site 446470002978 RPB11 interaction site [polypeptide binding]; other site 446470002979 RPB3 interaction site [polypeptide binding]; other site 446470002980 RPB12 interaction site [polypeptide binding]; other site 446470002981 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 446470002982 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 446470002983 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 446470002984 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 446470002985 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 446470002986 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446470002987 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 446470002988 G-loop; other site 446470002989 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446470002990 DNA binding site [nucleotide binding] 446470002991 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 446470002992 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446470002993 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446470002994 S17 interaction site [polypeptide binding]; other site 446470002995 S8 interaction site; other site 446470002996 16S rRNA interaction site [nucleotide binding]; other site 446470002997 streptomycin interaction site [chemical binding]; other site 446470002998 23S rRNA interaction site [nucleotide binding]; other site 446470002999 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446470003000 30S ribosomal protein S7; Validated; Region: PRK05302 446470003001 elongation factor G; Reviewed; Region: PRK00007 446470003002 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 446470003003 G1 box; other site 446470003004 putative GEF interaction site [polypeptide binding]; other site 446470003005 GTP/Mg2+ binding site [chemical binding]; other site 446470003006 Switch I region; other site 446470003007 G2 box; other site 446470003008 G3 box; other site 446470003009 Switch II region; other site 446470003010 G4 box; other site 446470003011 G5 box; other site 446470003012 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446470003013 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446470003014 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446470003015 elongation factor Tu; Reviewed; Region: PRK00049 446470003016 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 446470003017 G1 box; other site 446470003018 GEF interaction site [polypeptide binding]; other site 446470003019 GTP/Mg2+ binding site [chemical binding]; other site 446470003020 Switch I region; other site 446470003021 G2 box; other site 446470003022 G3 box; other site 446470003023 Switch II region; other site 446470003024 G4 box; other site 446470003025 G5 box; other site 446470003026 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446470003027 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 446470003028 Antibiotic Binding Site [chemical binding]; other site 446470003029 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 446470003030 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 446470003031 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 446470003032 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 446470003033 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446470003034 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446470003035 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446470003036 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 446470003037 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446470003038 putative translocon binding site; other site 446470003039 protein-rRNA interface [nucleotide binding]; other site 446470003040 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 446470003041 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 446470003042 G-X-X-G motif; other site 446470003043 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446470003044 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446470003045 23S rRNA interface [nucleotide binding]; other site 446470003046 5S rRNA interface [nucleotide binding]; other site 446470003047 putative antibiotic binding site [chemical binding]; other site 446470003048 L25 interface [polypeptide binding]; other site 446470003049 L27 interface [polypeptide binding]; other site 446470003050 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 446470003051 23S rRNA interface [nucleotide binding]; other site 446470003052 putative translocon interaction site; other site 446470003053 signal recognition particle (SRP54) interaction site; other site 446470003054 L23 interface [polypeptide binding]; other site 446470003055 trigger factor interaction site; other site 446470003056 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 446470003057 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 446470003058 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 446470003059 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 446470003060 RNA binding site [nucleotide binding]; other site 446470003061 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446470003062 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446470003063 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446470003064 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 446470003065 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 446470003066 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446470003067 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446470003068 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446470003069 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446470003070 23S rRNA interface [nucleotide binding]; other site 446470003071 5S rRNA interface [nucleotide binding]; other site 446470003072 L27 interface [polypeptide binding]; other site 446470003073 L5 interface [polypeptide binding]; other site 446470003074 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446470003075 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446470003076 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446470003077 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 446470003078 23S rRNA binding site [nucleotide binding]; other site 446470003079 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 446470003080 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446470003081 SecY translocase; Region: SecY; pfam00344 446470003082 adenylate kinase; Reviewed; Region: adk; PRK00279 446470003083 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446470003084 AMP-binding site [chemical binding]; other site 446470003085 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446470003086 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446470003087 active site 446470003088 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446470003089 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446470003090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470003091 S-adenosylmethionine binding site [chemical binding]; other site 446470003092 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446470003093 rRNA binding site [nucleotide binding]; other site 446470003094 predicted 30S ribosome binding site; other site 446470003095 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 446470003096 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 446470003097 30S ribosomal protein S13; Region: bact_S13; TIGR03631 446470003098 30S ribosomal protein S11; Validated; Region: PRK05309 446470003099 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446470003100 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446470003101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446470003102 RNA binding surface [nucleotide binding]; other site 446470003103 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446470003104 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446470003105 alphaNTD homodimer interface [polypeptide binding]; other site 446470003106 alphaNTD - beta interaction site [polypeptide binding]; other site 446470003107 alphaNTD - beta' interaction site [polypeptide binding]; other site 446470003108 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 446470003109 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 446470003110 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446470003111 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 446470003112 dimerization interface 3.5A [polypeptide binding]; other site 446470003113 active site 446470003114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470003115 S-adenosylmethionine binding site [chemical binding]; other site 446470003116 isocitrate dehydrogenase; Validated; Region: PRK08299 446470003117 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 446470003118 regulatory protein interface [polypeptide binding]; other site 446470003119 regulatory phosphorylation site [posttranslational modification]; other site 446470003120 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446470003121 Part of AAA domain; Region: AAA_19; pfam13245 446470003122 Family description; Region: UvrD_C_2; pfam13538 446470003123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470003124 putative DNA binding site [nucleotide binding]; other site 446470003125 dimerization interface [polypeptide binding]; other site 446470003126 putative Zn2+ binding site [ion binding]; other site 446470003127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003128 putative substrate translocation pore; other site 446470003129 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 446470003130 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 446470003131 metal binding site [ion binding]; metal-binding site 446470003132 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470003133 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470003134 ligand binding site [chemical binding]; other site 446470003135 flexible hinge region; other site 446470003136 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446470003137 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470003138 Protein of unknown function (DUF418); Region: DUF418; cl12135 446470003139 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 446470003140 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 446470003141 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 446470003142 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 446470003143 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 446470003144 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446470003145 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 446470003146 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 446470003147 FAD binding pocket [chemical binding]; other site 446470003148 FAD binding motif [chemical binding]; other site 446470003149 phosphate binding motif [ion binding]; other site 446470003150 beta-alpha-beta structure motif; other site 446470003151 NAD(p) ribose binding residues [chemical binding]; other site 446470003152 NAD binding pocket [chemical binding]; other site 446470003153 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 446470003154 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446470003155 catalytic loop [active] 446470003156 iron binding site [ion binding]; other site 446470003157 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446470003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003159 putative substrate translocation pore; other site 446470003160 short chain dehydrogenase; Provisional; Region: PRK06500 446470003161 classical (c) SDRs; Region: SDR_c; cd05233 446470003162 NAD(P) binding site [chemical binding]; other site 446470003163 active site 446470003164 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470003165 DNA binding site [nucleotide binding] 446470003166 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470003167 AAA ATPase domain; Region: AAA_16; pfam13191 446470003168 Predicted ATPase [General function prediction only]; Region: COG3903 446470003169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470003170 binding surface 446470003171 TPR motif; other site 446470003172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470003173 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446470003174 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470003175 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446470003176 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 446470003177 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446470003178 active site 446470003179 Ca binding site [ion binding]; other site 446470003180 catalytic site [active] 446470003181 Aamy_C domain; Region: Aamy_C; smart00632 446470003182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470003183 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 446470003184 NAD(P) binding site [chemical binding]; other site 446470003185 active site 446470003186 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446470003187 Protein kinase domain; Region: Pkinase; pfam00069 446470003188 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470003189 active site 446470003190 ATP binding site [chemical binding]; other site 446470003191 substrate binding site [chemical binding]; other site 446470003192 activation loop (A-loop); other site 446470003193 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446470003194 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470003195 calcium binding site 2 [ion binding]; other site 446470003196 active site 446470003197 catalytic triad [active] 446470003198 calcium binding site 1 [ion binding]; other site 446470003199 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446470003200 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446470003201 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470003202 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470003203 active site 446470003204 ATP binding site [chemical binding]; other site 446470003205 substrate binding site [chemical binding]; other site 446470003206 activation loop (A-loop); other site 446470003207 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446470003208 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446470003209 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470003210 calcium binding site 2 [ion binding]; other site 446470003211 active site 446470003212 catalytic triad [active] 446470003213 calcium binding site 1 [ion binding]; other site 446470003214 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446470003215 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 446470003216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470003217 FeS/SAM binding site; other site 446470003218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470003219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470003221 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470003222 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470003223 DNA binding residues [nucleotide binding] 446470003224 YCII-related domain; Region: YCII; cl00999 446470003225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470003226 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470003227 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470003228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446470003229 AsnC family; Region: AsnC_trans_reg; pfam01037 446470003230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470003231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003232 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 446470003233 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470003234 NAD binding site [chemical binding]; other site 446470003235 substrate binding site [chemical binding]; other site 446470003236 putative active site [active] 446470003237 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 446470003238 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 446470003239 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446470003240 putative active site [active] 446470003241 putative FMN binding site [chemical binding]; other site 446470003242 putative substrate binding site [chemical binding]; other site 446470003243 putative catalytic residue [active] 446470003244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470003245 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470003246 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446470003247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470003248 S-adenosylmethionine binding site [chemical binding]; other site 446470003249 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446470003250 NADH dehydrogenase subunit A; Validated; Region: PRK07928 446470003251 NADH dehydrogenase subunit B; Validated; Region: PRK06411 446470003252 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 446470003253 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 446470003254 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 446470003255 NADH dehydrogenase subunit D; Validated; Region: PRK06075 446470003256 NADH dehydrogenase subunit E; Validated; Region: PRK07539 446470003257 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 446470003258 putative dimer interface [polypeptide binding]; other site 446470003259 [2Fe-2S] cluster binding site [ion binding]; other site 446470003260 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 446470003261 SLBB domain; Region: SLBB; pfam10531 446470003262 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 446470003263 NADH dehydrogenase subunit G; Validated; Region: PRK07860 446470003264 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446470003265 catalytic loop [active] 446470003266 iron binding site [ion binding]; other site 446470003267 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 446470003268 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446470003269 molybdopterin cofactor binding site; other site 446470003270 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 446470003271 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 446470003272 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 446470003273 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 446470003274 4Fe-4S binding domain; Region: Fer4; pfam00037 446470003275 4Fe-4S binding domain; Region: Fer4; pfam00037 446470003276 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 446470003277 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 446470003278 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 446470003279 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 446470003280 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 446470003281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446470003282 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 446470003283 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446470003284 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 446470003285 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446470003286 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446470003287 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446470003288 Substrate binding site; other site 446470003289 Mg++ binding site; other site 446470003290 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446470003291 active site 446470003292 substrate binding site [chemical binding]; other site 446470003293 CoA binding site [chemical binding]; other site 446470003294 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446470003295 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 446470003296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470003297 active site 446470003298 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 446470003299 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 446470003300 5S rRNA interface [nucleotide binding]; other site 446470003301 CTC domain interface [polypeptide binding]; other site 446470003302 L16 interface [polypeptide binding]; other site 446470003303 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446470003304 putative active site [active] 446470003305 catalytic residue [active] 446470003306 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446470003307 Bacterial sugar transferase; Region: Bac_transf; pfam02397 446470003308 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 446470003309 active site 446470003310 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 446470003311 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446470003312 Active Sites [active] 446470003313 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 446470003314 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 446470003315 CysD dimerization site [polypeptide binding]; other site 446470003316 G1 box; other site 446470003317 putative GEF interaction site [polypeptide binding]; other site 446470003318 GTP/Mg2+ binding site [chemical binding]; other site 446470003319 Switch I region; other site 446470003320 G2 box; other site 446470003321 G3 box; other site 446470003322 Switch II region; other site 446470003323 G4 box; other site 446470003324 G5 box; other site 446470003325 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 446470003326 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 446470003327 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470003328 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 446470003329 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446470003330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 446470003331 homoserine kinase; Provisional; Region: PRK01212 446470003332 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 446470003333 transcription termination factor Rho; Provisional; Region: PRK12608 446470003334 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446470003335 RNA binding site [nucleotide binding]; other site 446470003336 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 446470003337 multimer interface [polypeptide binding]; other site 446470003338 Walker A motif; other site 446470003339 ATP binding site [chemical binding]; other site 446470003340 Walker B motif; other site 446470003341 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 446470003342 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470003343 active site 446470003344 metal binding site [ion binding]; metal-binding site 446470003345 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 446470003346 peptide chain release factor 1; Validated; Region: prfA; PRK00591 446470003347 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446470003348 RF-1 domain; Region: RF-1; pfam00472 446470003349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470003350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470003351 metal binding site [ion binding]; metal-binding site 446470003352 active site 446470003353 I-site; other site 446470003354 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446470003355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470003356 S-adenosylmethionine binding site [chemical binding]; other site 446470003357 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 446470003358 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446470003359 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 446470003360 active site 446470003361 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 446470003362 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 446470003363 ATP synthase subunit C; Region: ATP-synt_C; cl00466 446470003364 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 446470003365 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 446470003366 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 446470003367 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 446470003368 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446470003369 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446470003370 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446470003371 beta subunit interaction interface [polypeptide binding]; other site 446470003372 Walker A motif; other site 446470003373 ATP binding site [chemical binding]; other site 446470003374 Walker B motif; other site 446470003375 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446470003376 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 446470003377 core domain interface [polypeptide binding]; other site 446470003378 delta subunit interface [polypeptide binding]; other site 446470003379 epsilon subunit interface [polypeptide binding]; other site 446470003380 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446470003381 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446470003382 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446470003383 alpha subunit interaction interface [polypeptide binding]; other site 446470003384 Walker A motif; other site 446470003385 ATP binding site [chemical binding]; other site 446470003386 Walker B motif; other site 446470003387 inhibitor binding site; inhibition site 446470003388 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446470003389 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446470003390 pyridoxal phosphate enzyme, MJ0158 family; Region: pyridox_MJ0158; TIGR03576 446470003391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470003392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470003393 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470003394 putative dimerization interface [polypeptide binding]; other site 446470003395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470003396 dimerization interface [polypeptide binding]; other site 446470003397 putative DNA binding site [nucleotide binding]; other site 446470003398 putative Zn2+ binding site [ion binding]; other site 446470003399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003400 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470003401 putative substrate translocation pore; other site 446470003402 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 446470003403 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 446470003404 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 446470003405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446470003406 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470003407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470003408 NAD(P) binding site [chemical binding]; other site 446470003409 active site 446470003410 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470003411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470003412 putative DNA binding site [nucleotide binding]; other site 446470003413 putative Zn2+ binding site [ion binding]; other site 446470003414 AsnC family; Region: AsnC_trans_reg; pfam01037 446470003415 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446470003416 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 446470003417 active site 446470003418 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446470003419 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446470003420 putative thiostrepton binding site; other site 446470003421 23S rRNA interface [nucleotide binding]; other site 446470003422 L7/L12 interface [polypeptide binding]; other site 446470003423 L25 interface [polypeptide binding]; other site 446470003424 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446470003425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470003426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446470003427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003428 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446470003429 Dienelactone hydrolase family; Region: DLH; pfam01738 446470003430 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 446470003431 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 446470003432 G1 box; other site 446470003433 putative GEF interaction site [polypeptide binding]; other site 446470003434 GTP/Mg2+ binding site [chemical binding]; other site 446470003435 Switch I region; other site 446470003436 G2 box; other site 446470003437 G3 box; other site 446470003438 Switch II region; other site 446470003439 G4 box; other site 446470003440 G5 box; other site 446470003441 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 446470003442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470003443 NmrA-like family; Region: NmrA; pfam05368 446470003444 NAD(P) binding site [chemical binding]; other site 446470003445 active site 446470003446 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 446470003447 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446470003448 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446470003449 catalytic residues [active] 446470003450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470003451 NB-ARC domain; Region: NB-ARC; pfam00931 446470003452 Walker A motif; other site 446470003453 ATP binding site [chemical binding]; other site 446470003454 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470003455 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470003456 active site 446470003457 ATP binding site [chemical binding]; other site 446470003458 substrate binding site [chemical binding]; other site 446470003459 activation loop (A-loop); other site 446470003460 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446470003461 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446470003462 putative sugar binding sites [chemical binding]; other site 446470003463 Q-X-W motif; other site 446470003464 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446470003465 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446470003466 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 446470003467 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446470003468 ligand binding site [chemical binding]; other site 446470003469 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446470003470 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446470003471 Walker A/P-loop; other site 446470003472 ATP binding site [chemical binding]; other site 446470003473 Q-loop/lid; other site 446470003474 ABC transporter signature motif; other site 446470003475 Walker B; other site 446470003476 D-loop; other site 446470003477 H-loop/switch region; other site 446470003478 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446470003479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470003480 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446470003481 TM-ABC transporter signature motif; other site 446470003482 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470003483 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446470003484 TM-ABC transporter signature motif; other site 446470003485 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446470003486 active site 446470003487 catalytic motif [active] 446470003488 Zn binding site [ion binding]; other site 446470003489 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446470003490 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446470003491 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446470003492 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 446470003493 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 446470003494 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470003495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470003496 NAD(P) binding site [chemical binding]; other site 446470003497 active site 446470003498 DoxX-like family; Region: DoxX_2; pfam13564 446470003499 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446470003500 adenosine deaminase; Provisional; Region: PRK09358 446470003501 active site 446470003502 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446470003503 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446470003504 active site 446470003505 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446470003506 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446470003507 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446470003508 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 446470003509 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470003510 Beta-lactamase; Region: Beta-lactamase; cl17358 446470003511 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470003512 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470003513 Predicted transcriptional regulators [Transcription]; Region: COG1725 446470003514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470003515 DNA-binding site [nucleotide binding]; DNA binding site 446470003516 trigger factor; Provisional; Region: tig; PRK01490 446470003517 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446470003518 Clp protease; Region: CLP_protease; pfam00574 446470003519 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446470003520 oligomer interface [polypeptide binding]; other site 446470003521 active site residues [active] 446470003522 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446470003523 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446470003524 oligomer interface [polypeptide binding]; other site 446470003525 active site residues [active] 446470003526 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446470003527 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446470003528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470003529 Walker A motif; other site 446470003530 ATP binding site [chemical binding]; other site 446470003531 Walker B motif; other site 446470003532 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 446470003533 Erythromycin esterase; Region: Erythro_esteras; cl17110 446470003534 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470003535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470003536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470003537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446470003538 dimerization interface [polypeptide binding]; other site 446470003539 META domain; Region: META; pfam03724 446470003540 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 446470003541 EamA-like transporter family; Region: EamA; pfam00892 446470003542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470003543 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470003544 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470003545 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470003546 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446470003547 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446470003548 Walker A motif; other site 446470003549 ATP binding site [chemical binding]; other site 446470003550 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446470003551 Dimer interface [polypeptide binding]; other site 446470003552 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470003553 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470003554 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446470003555 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446470003556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470003557 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446470003558 Walker A/P-loop; other site 446470003559 ATP binding site [chemical binding]; other site 446470003560 Q-loop/lid; other site 446470003561 ABC transporter signature motif; other site 446470003562 Walker B; other site 446470003563 D-loop; other site 446470003564 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470003566 Walker A/P-loop; other site 446470003567 ATP binding site [chemical binding]; other site 446470003568 Q-loop/lid; other site 446470003569 ABC transporter signature motif; other site 446470003570 Walker B; other site 446470003571 D-loop; other site 446470003572 H-loop/switch region; other site 446470003573 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 446470003574 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 446470003575 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446470003576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470003577 S-adenosylmethionine binding site [chemical binding]; other site 446470003578 NACHT domain; Region: NACHT; pfam05729 446470003579 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 446470003580 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 446470003581 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470003582 putative catalytic site [active] 446470003583 putative phosphate binding site [ion binding]; other site 446470003584 putative metal binding site [ion binding]; other site 446470003585 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470003586 putative metal binding site [ion binding]; other site 446470003587 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470003588 putative metal binding site [ion binding]; other site 446470003589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470003590 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470003591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470003592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470003593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470003594 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446470003595 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 446470003596 putative DNA binding site [nucleotide binding]; other site 446470003597 catalytic residue [active] 446470003598 putative H2TH interface [polypeptide binding]; other site 446470003599 putative catalytic residues [active] 446470003600 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446470003601 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446470003602 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470003603 TIGR03086 family protein; Region: TIGR03086 446470003604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470003605 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446470003606 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446470003607 NAD binding site [chemical binding]; other site 446470003608 catalytic Zn binding site [ion binding]; other site 446470003609 substrate binding site [chemical binding]; other site 446470003610 structural Zn binding site [ion binding]; other site 446470003611 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446470003612 active site 446470003613 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446470003614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470003615 Walker A/P-loop; other site 446470003616 ATP binding site [chemical binding]; other site 446470003617 Q-loop/lid; other site 446470003618 ABC transporter signature motif; other site 446470003619 Walker B; other site 446470003620 D-loop; other site 446470003621 H-loop/switch region; other site 446470003622 TOBE domain; Region: TOBE_2; pfam08402 446470003623 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470003624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470003625 conserved gate region; other site 446470003626 putative PBP binding loops; other site 446470003627 ABC-ATPase subunit interface; other site 446470003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470003629 dimer interface [polypeptide binding]; other site 446470003630 conserved gate region; other site 446470003631 putative PBP binding loops; other site 446470003632 ABC-ATPase subunit interface; other site 446470003633 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470003634 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446470003635 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446470003636 active site 446470003637 FtsX-like permease family; Region: FtsX; pfam02687 446470003638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470003639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470003640 Walker A/P-loop; other site 446470003641 ATP binding site [chemical binding]; other site 446470003642 Q-loop/lid; other site 446470003643 ABC transporter signature motif; other site 446470003644 Walker B; other site 446470003645 D-loop; other site 446470003646 H-loop/switch region; other site 446470003647 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470003648 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470003649 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 446470003650 dinuclear metal binding motif [ion binding]; other site 446470003651 ribosome maturation protein RimP; Reviewed; Region: PRK00092 446470003652 Sm and related proteins; Region: Sm_like; cl00259 446470003653 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 446470003654 putative oligomer interface [polypeptide binding]; other site 446470003655 putative RNA binding site [nucleotide binding]; other site 446470003656 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446470003657 NusA N-terminal domain; Region: NusA_N; pfam08529 446470003658 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 446470003659 RNA binding site [nucleotide binding]; other site 446470003660 homodimer interface [polypeptide binding]; other site 446470003661 NusA-like KH domain; Region: KH_5; pfam13184 446470003662 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446470003663 G-X-X-G motif; other site 446470003664 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446470003665 translation initiation factor IF-2; Region: IF-2; TIGR00487 446470003666 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446470003667 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 446470003668 G1 box; other site 446470003669 putative GEF interaction site [polypeptide binding]; other site 446470003670 GTP/Mg2+ binding site [chemical binding]; other site 446470003671 Switch I region; other site 446470003672 G2 box; other site 446470003673 G3 box; other site 446470003674 Switch II region; other site 446470003675 G4 box; other site 446470003676 G5 box; other site 446470003677 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 446470003678 Translation-initiation factor 2; Region: IF-2; pfam11987 446470003679 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 446470003680 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446470003681 catalytic site [active] 446470003682 putative active site [active] 446470003683 putative substrate binding site [chemical binding]; other site 446470003684 dimer interface [polypeptide binding]; other site 446470003685 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 446470003686 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446470003687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470003688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446470003689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470003690 DNA binding residues [nucleotide binding] 446470003691 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470003692 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470003693 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 446470003694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470003695 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 446470003696 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470003697 DNA binding residues [nucleotide binding] 446470003698 putative dimer interface [polypeptide binding]; other site 446470003699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470003700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003701 putative substrate translocation pore; other site 446470003702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470003704 putative DNA binding site [nucleotide binding]; other site 446470003705 dimerization interface [polypeptide binding]; other site 446470003706 putative Zn2+ binding site [ion binding]; other site 446470003707 Uncharacterized conserved protein [Function unknown]; Region: COG4279 446470003708 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446470003709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470003710 ATP binding site [chemical binding]; other site 446470003711 putative Mg++ binding site [ion binding]; other site 446470003712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470003713 nucleotide binding region [chemical binding]; other site 446470003714 ATP-binding site [chemical binding]; other site 446470003715 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 446470003716 putative active site [active] 446470003717 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 446470003718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470003719 active site 446470003720 phosphorylation site [posttranslational modification] 446470003721 intermolecular recognition site; other site 446470003722 dimerization interface [polypeptide binding]; other site 446470003723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470003724 DNA binding site [nucleotide binding] 446470003725 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446470003726 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 446470003727 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 446470003728 Ligand Binding Site [chemical binding]; other site 446470003729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470003730 dimer interface [polypeptide binding]; other site 446470003731 phosphorylation site [posttranslational modification] 446470003732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470003733 ATP binding site [chemical binding]; other site 446470003734 Mg2+ binding site [ion binding]; other site 446470003735 G-X-G motif; other site 446470003736 K+-transporting ATPase, c chain; Region: KdpC; cl00944 446470003737 K+-transporting ATPase, c chain; Region: KdpC; cl00944 446470003738 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 446470003739 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446470003740 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446470003741 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 446470003742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470003743 dimerization interface [polypeptide binding]; other site 446470003744 putative DNA binding site [nucleotide binding]; other site 446470003745 putative Zn2+ binding site [ion binding]; other site 446470003746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470003748 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470003749 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470003750 Peptidase M15; Region: Peptidase_M15_3; pfam08291 446470003751 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446470003752 putative active site [active] 446470003753 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 446470003754 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470003755 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470003756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470003757 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470003758 Walker A/P-loop; other site 446470003759 ATP binding site [chemical binding]; other site 446470003760 Q-loop/lid; other site 446470003761 ABC transporter signature motif; other site 446470003762 Walker B; other site 446470003763 D-loop; other site 446470003764 H-loop/switch region; other site 446470003765 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446470003766 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470003767 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446470003768 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470003769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470003770 NAD(P) binding site [chemical binding]; other site 446470003771 active site 446470003772 Protein of unknown function (DUF503); Region: DUF503; cl00669 446470003773 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 446470003774 putative efflux protein, MATE family; Region: matE; TIGR00797 446470003775 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 446470003776 MMPL family; Region: MMPL; pfam03176 446470003777 MMPL family; Region: MMPL; pfam03176 446470003778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470003779 putative DNA binding site [nucleotide binding]; other site 446470003780 dimerization interface [polypeptide binding]; other site 446470003781 putative Zn2+ binding site [ion binding]; other site 446470003782 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 446470003783 putative active site pocket [active] 446470003784 cleavage site 446470003785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470003786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003787 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470003788 Predicted membrane protein [Function unknown]; Region: COG2311 446470003789 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470003790 Predicted methyltransferases [General function prediction only]; Region: COG1568 446470003791 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446470003792 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470003793 FkbH-like domain; Region: FkbH; TIGR01686 446470003794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470003795 active site 446470003796 motif I; other site 446470003797 motif II; other site 446470003798 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446470003799 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 446470003800 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 446470003801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470003802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003804 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470003805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446470003806 Coenzyme A binding pocket [chemical binding]; other site 446470003807 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 446470003808 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470003809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470003810 non-specific DNA binding site [nucleotide binding]; other site 446470003811 salt bridge; other site 446470003812 sequence-specific DNA binding site [nucleotide binding]; other site 446470003813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470003814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470003815 DNA binding residues [nucleotide binding] 446470003816 dimerization interface [polypeptide binding]; other site 446470003817 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470003818 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470003819 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470003820 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470003821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470003822 active site 446470003823 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 446470003824 homodimer interface [polypeptide binding]; other site 446470003825 homotetramer interface [polypeptide binding]; other site 446470003826 active site pocket [active] 446470003827 cleavage site 446470003828 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 446470003829 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446470003830 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446470003831 active site 446470003832 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 446470003833 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 446470003834 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446470003835 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470003836 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470003837 NB-ARC domain; Region: NB-ARC; pfam00931 446470003838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470003839 binding surface 446470003840 TPR motif; other site 446470003841 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470003842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470003843 binding surface 446470003844 TPR motif; other site 446470003845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470003846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470003847 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 446470003848 cystathionine gamma-synthase; Provisional; Region: PRK07811 446470003849 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446470003850 homodimer interface [polypeptide binding]; other site 446470003851 substrate-cofactor binding pocket; other site 446470003852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470003853 catalytic residue [active] 446470003854 amidase; Provisional; Region: PRK12470 446470003855 Amidase; Region: Amidase; cl11426 446470003856 Amidase; Region: Amidase; cl11426 446470003857 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470003858 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470003859 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 446470003860 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 446470003861 active site 446470003862 substrate binding site [chemical binding]; other site 446470003863 FMN binding site [chemical binding]; other site 446470003864 putative catalytic residues [active] 446470003865 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446470003866 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 446470003867 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470003868 substrate binding site [chemical binding]; other site 446470003869 oxyanion hole (OAH) forming residues; other site 446470003870 trimer interface [polypeptide binding]; other site 446470003871 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 446470003872 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 446470003873 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 446470003874 RibD C-terminal domain; Region: RibD_C; cl17279 446470003875 MMPL family; Region: MMPL; pfam03176 446470003876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470003877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470003878 active site 446470003879 phosphorylation site [posttranslational modification] 446470003880 intermolecular recognition site; other site 446470003881 dimerization interface [polypeptide binding]; other site 446470003882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470003883 DNA binding residues [nucleotide binding] 446470003884 dimerization interface [polypeptide binding]; other site 446470003885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470003886 Histidine kinase; Region: HisKA_3; pfam07730 446470003887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470003888 ATP binding site [chemical binding]; other site 446470003889 Mg2+ binding site [ion binding]; other site 446470003890 G-X-G motif; other site 446470003891 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 446470003892 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446470003893 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446470003894 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 446470003895 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446470003896 TrkA-N domain; Region: TrkA_N; pfam02254 446470003897 TrkA-C domain; Region: TrkA_C; pfam02080 446470003898 Nitrate and nitrite sensing; Region: NIT; pfam08376 446470003899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470003900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470003901 ATP binding site [chemical binding]; other site 446470003902 G-X-G motif; other site 446470003903 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 446470003904 Phosphotransferase enzyme family; Region: APH; pfam01636 446470003905 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470003906 active site 446470003907 substrate binding site [chemical binding]; other site 446470003908 ATP binding site [chemical binding]; other site 446470003909 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446470003910 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446470003911 D-pathway; other site 446470003912 Putative ubiquinol binding site [chemical binding]; other site 446470003913 Low-spin heme (heme b) binding site [chemical binding]; other site 446470003914 Putative water exit pathway; other site 446470003915 Binuclear center (heme o3/CuB) [ion binding]; other site 446470003916 K-pathway; other site 446470003917 Putative proton exit pathway; other site 446470003918 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 446470003919 Sel1-like repeats; Region: SEL1; smart00671 446470003920 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 446470003921 Isochorismatase family; Region: Isochorismatase; pfam00857 446470003922 catalytic triad [active] 446470003923 metal binding site [ion binding]; metal-binding site 446470003924 conserved cis-peptide bond; other site 446470003925 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446470003926 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 446470003927 active site 446470003928 Protease prsW family; Region: PrsW-protease; pfam13367 446470003929 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 446470003930 active site 446470003931 catalytic triad [active] 446470003932 oxyanion hole [active] 446470003933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003934 putative substrate translocation pore; other site 446470003935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470003936 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470003937 MarR family; Region: MarR_2; pfam12802 446470003938 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470003939 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470003940 putative NAD(P) binding site [chemical binding]; other site 446470003941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470003942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470003943 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 446470003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446470003945 short chain dehydrogenase; Provisional; Region: PRK06523 446470003946 classical (c) SDRs; Region: SDR_c; cd05233 446470003947 NAD(P) binding site [chemical binding]; other site 446470003948 active site 446470003949 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446470003950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470003951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470003952 DNA binding residues [nucleotide binding] 446470003953 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446470003954 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446470003955 DNA binding site [nucleotide binding] 446470003956 active site 446470003957 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470003958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470003959 sequence-specific DNA binding site [nucleotide binding]; other site 446470003960 salt bridge; other site 446470003961 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446470003962 active site 446470003963 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446470003964 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446470003965 substrate binding site [chemical binding]; other site 446470003966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470003967 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 446470003968 MPN+ (JAMM) motif; other site 446470003969 Zinc-binding site [ion binding]; other site 446470003970 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 446470003971 MoaE interaction surface [polypeptide binding]; other site 446470003972 MoeB interaction surface [polypeptide binding]; other site 446470003973 thiocarboxylated glycine; other site 446470003974 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446470003975 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446470003976 dimer interface [polypeptide binding]; other site 446470003977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470003978 catalytic residue [active] 446470003979 glutamate racemase; Provisional; Region: PRK00865 446470003980 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446470003981 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 446470003982 active site 446470003983 dimerization interface [polypeptide binding]; other site 446470003984 ribonuclease PH; Reviewed; Region: rph; PRK00173 446470003985 Ribonuclease PH; Region: RNase_PH_bact; cd11362 446470003986 hexamer interface [polypeptide binding]; other site 446470003987 active site 446470003988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446470003989 active site 446470003990 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470003991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470003992 DNA-binding site [nucleotide binding]; DNA binding site 446470003993 FCD domain; Region: FCD; pfam07729 446470003994 DctM-like transporters; Region: DctM; pfam06808 446470003995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 446470003996 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446470003997 intersubunit interface [polypeptide binding]; other site 446470003998 active site 446470003999 Zn2+ binding site [ion binding]; other site 446470004000 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446470004001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446470004002 Phosphotransferase enzyme family; Region: APH; pfam01636 446470004003 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470004004 active site 446470004005 ATP binding site [chemical binding]; other site 446470004006 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 446470004007 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 446470004008 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 446470004009 putative ligand binding site [chemical binding]; other site 446470004010 putative NAD binding site [chemical binding]; other site 446470004011 catalytic site [active] 446470004012 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446470004013 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446470004014 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470004015 calcium binding site 2 [ion binding]; other site 446470004016 active site 446470004017 catalytic triad [active] 446470004018 calcium binding site 1 [ion binding]; other site 446470004019 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 446470004020 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446470004021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470004022 dimer interface [polypeptide binding]; other site 446470004023 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 446470004024 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446470004025 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446470004026 catalytic triad [active] 446470004027 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 446470004028 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446470004029 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446470004030 DoxX-like family; Region: DoxX_2; pfam13564 446470004031 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 446470004032 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446470004033 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 446470004034 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 446470004035 PDGLE domain; Region: PDGLE; pfam13190 446470004036 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 446470004037 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470004038 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446470004039 Walker A/P-loop; other site 446470004040 ATP binding site [chemical binding]; other site 446470004041 Q-loop/lid; other site 446470004042 ABC transporter signature motif; other site 446470004043 Walker B; other site 446470004044 D-loop; other site 446470004045 H-loop/switch region; other site 446470004046 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 446470004047 EamA-like transporter family; Region: EamA; pfam00892 446470004048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004050 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470004051 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 446470004052 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 446470004053 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 446470004054 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446470004055 potential catalytic triad [active] 446470004056 conserved cys residue [active] 446470004057 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470004058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470004059 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446470004060 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 446470004061 nucleotide binding site/active site [active] 446470004062 HIT family signature motif; other site 446470004063 catalytic residue [active] 446470004064 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446470004065 Sulfatase; Region: Sulfatase; pfam00884 446470004066 Ion channel; Region: Ion_trans_2; pfam07885 446470004067 PhoD-like phosphatase; Region: PhoD; pfam09423 446470004068 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446470004069 putative active site [active] 446470004070 putative metal binding site [ion binding]; other site 446470004071 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470004072 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 446470004073 active site 446470004074 catalytic residues [active] 446470004075 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446470004076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470004077 CHAT domain; Region: CHAT; pfam12770 446470004078 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 446470004079 MoxR-like ATPases [General function prediction only]; Region: COG0714 446470004080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470004081 Walker A motif; other site 446470004082 ATP binding site [chemical binding]; other site 446470004083 Walker B motif; other site 446470004084 arginine finger; other site 446470004085 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446470004086 Protein of unknown function DUF58; Region: DUF58; pfam01882 446470004087 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446470004088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470004089 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 446470004090 hypothetical protein; Provisional; Region: PRK03298 446470004091 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 446470004092 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 446470004093 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 446470004094 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 446470004095 Protein of unknown function (DUF499); Region: DUF499; pfam04465 446470004096 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446470004097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470004098 ATP binding site [chemical binding]; other site 446470004099 putative Mg++ binding site [ion binding]; other site 446470004100 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 446470004101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470004102 nucleotide binding region [chemical binding]; other site 446470004103 ATP-binding site [chemical binding]; other site 446470004104 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 446470004105 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446470004106 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470004107 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 446470004108 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446470004109 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446470004110 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470004111 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470004112 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446470004113 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 446470004114 NAD(P) binding site [chemical binding]; other site 446470004115 catalytic residues [active] 446470004116 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446470004117 Peptidase family M28; Region: Peptidase_M28; pfam04389 446470004118 active site 446470004119 metal binding site [ion binding]; metal-binding site 446470004120 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 446470004121 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446470004122 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446470004123 active site 446470004124 ATP binding site [chemical binding]; other site 446470004125 substrate binding site [chemical binding]; other site 446470004126 activation loop (A-loop); other site 446470004127 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446470004128 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470004129 V-type ATP synthase subunit E; Provisional; Region: PRK01558 446470004130 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446470004131 Integral membrane protein DUF95; Region: DUF95; pfam01944 446470004132 RDD family; Region: RDD; pfam06271 446470004133 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 446470004134 mismatch recognition site; other site 446470004135 additional DNA contacts [nucleotide binding]; other site 446470004136 active site 446470004137 zinc binding site [ion binding]; other site 446470004138 DNA intercalation site [nucleotide binding]; other site 446470004139 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 446470004140 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446470004141 cofactor binding site; other site 446470004142 DNA binding site [nucleotide binding] 446470004143 substrate interaction site [chemical binding]; other site 446470004144 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446470004145 Protein of unknown function DUF262; Region: DUF262; pfam03235 446470004146 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446470004147 active site 446470004148 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470004149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470004150 DNA-binding site [nucleotide binding]; DNA binding site 446470004151 FCD domain; Region: FCD; pfam07729 446470004152 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446470004153 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446470004154 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 446470004155 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 446470004156 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 446470004157 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 446470004158 PQQ-like domain; Region: PQQ_2; pfam13360 446470004159 PQQ-like domain; Region: PQQ_2; pfam13360 446470004160 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470004161 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470004162 active site 446470004163 catalytic tetrad [active] 446470004164 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446470004165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004167 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470004168 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446470004169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004170 putative substrate translocation pore; other site 446470004171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004172 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470004173 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470004174 AAA ATPase domain; Region: AAA_16; pfam13191 446470004175 Predicted ATPase [General function prediction only]; Region: COG3903 446470004176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446470004177 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 446470004178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470004179 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446470004180 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 446470004181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470004182 Cytochrome P450; Region: p450; cl12078 446470004183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004184 S-adenosylmethionine binding site [chemical binding]; other site 446470004185 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446470004186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470004187 motif II; other site 446470004188 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446470004189 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470004190 active site 446470004191 ATP binding site [chemical binding]; other site 446470004192 substrate binding site [chemical binding]; other site 446470004193 activation loop (A-loop); other site 446470004194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470004195 NACHT domain; Region: NACHT; pfam05729 446470004196 Walker A motif; other site 446470004197 ATP binding site [chemical binding]; other site 446470004198 Walker B motif; other site 446470004199 arginine finger; other site 446470004200 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 446470004201 putative active site [active] 446470004202 Zn binding site [ion binding]; other site 446470004203 Sulfatase; Region: Sulfatase; cl17466 446470004204 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 446470004205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004206 S-adenosylmethionine binding site [chemical binding]; other site 446470004207 Predicted membrane protein [Function unknown]; Region: COG4270 446470004208 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446470004209 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446470004210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470004213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470004214 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470004215 active site 446470004216 catalytic tetrad [active] 446470004217 potential frameshift: common BLAST hit: gi|256376646|ref|YP_003100306.1| Tetratricopeptide TPR_4 446470004218 Putative serine esterase (DUF676); Region: DUF676; pfam05057 446470004219 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470004220 AAA ATPase domain; Region: AAA_16; pfam13191 446470004221 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004224 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 446470004225 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446470004226 homotrimer interaction site [polypeptide binding]; other site 446470004227 putative active site [active] 446470004228 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 446470004229 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470004230 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470004231 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446470004232 catalytic triad [active] 446470004233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470004235 putative substrate translocation pore; other site 446470004236 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470004237 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470004238 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 446470004239 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 446470004240 active site 446470004241 metal binding site [ion binding]; metal-binding site 446470004242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004244 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470004245 Predicted membrane protein [Function unknown]; Region: COG2311 446470004246 Protein of unknown function (DUF418); Region: DUF418; cl12135 446470004247 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470004248 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470004249 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470004250 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470004251 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446470004252 NAD(P) binding site [chemical binding]; other site 446470004253 hypothetical protein; Provisional; Region: PRK06184 446470004254 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470004255 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446470004256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004257 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470004258 Isochorismatase family; Region: Isochorismatase; pfam00857 446470004259 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446470004260 catalytic triad [active] 446470004261 conserved cis-peptide bond; other site 446470004262 Putative amidotransferase; Region: DUF4066; pfam13278 446470004263 conserved cys residue [active] 446470004264 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470004265 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470004266 conserved cys residue [active] 446470004267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470004268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470004269 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446470004270 Endonuclease I; Region: Endonuclease_1; pfam04231 446470004271 MMPL family; Region: MMPL; pfam03176 446470004272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004273 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 446470004274 dimer interface [polypeptide binding]; other site 446470004275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470004276 metal binding site [ion binding]; metal-binding site 446470004277 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470004278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004279 S-adenosylmethionine binding site [chemical binding]; other site 446470004280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 446470004281 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446470004282 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 446470004283 Rhodanese Homology Domain; Region: RHOD; smart00450 446470004284 active site residue [active] 446470004285 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470004286 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470004287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470004288 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470004289 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446470004290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004291 putative substrate translocation pore; other site 446470004292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004294 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470004295 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470004296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470004297 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470004298 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470004299 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470004300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470004301 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470004302 CHAT domain; Region: CHAT; pfam12770 446470004303 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470004304 cytosine deaminase; Provisional; Region: PRK05985 446470004305 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 446470004306 active site 446470004307 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446470004308 nucleoside/Zn binding site; other site 446470004309 dimer interface [polypeptide binding]; other site 446470004310 catalytic motif [active] 446470004311 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470004312 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470004313 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446470004314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470004315 DNA-binding site [nucleotide binding]; DNA binding site 446470004316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004317 S-adenosylmethionine binding site [chemical binding]; other site 446470004318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470004319 sequence-specific DNA binding site [nucleotide binding]; other site 446470004320 salt bridge; other site 446470004321 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446470004322 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 446470004323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 446470004324 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 446470004325 Uncharacterized conserved protein [Function unknown]; Region: COG5476 446470004326 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 446470004327 MlrC C-terminus; Region: MlrC_C; pfam07171 446470004328 hypothetical protein; Provisional; Region: PRK07236 446470004329 hypothetical protein; Provisional; Region: PRK07588 446470004330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470004331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470004332 active site 446470004333 catalytic tetrad [active] 446470004334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004335 dimerization interface [polypeptide binding]; other site 446470004336 putative DNA binding site [nucleotide binding]; other site 446470004337 putative Zn2+ binding site [ion binding]; other site 446470004338 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470004339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004340 S-adenosylmethionine binding site [chemical binding]; other site 446470004341 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470004342 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004343 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470004344 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004345 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004346 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470004347 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470004348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004349 Cation efflux family; Region: Cation_efflux; cl00316 446470004350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004351 dimerization interface [polypeptide binding]; other site 446470004352 putative DNA binding site [nucleotide binding]; other site 446470004353 putative Zn2+ binding site [ion binding]; other site 446470004354 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470004355 Cytochrome P450; Region: p450; cl12078 446470004356 Histidine kinase; Region: HisKA_3; pfam07730 446470004357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470004358 ATP binding site [chemical binding]; other site 446470004359 Mg2+ binding site [ion binding]; other site 446470004360 G-X-G motif; other site 446470004361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470004362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470004363 active site 446470004364 phosphorylation site [posttranslational modification] 446470004365 intermolecular recognition site; other site 446470004366 dimerization interface [polypeptide binding]; other site 446470004367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470004368 DNA binding residues [nucleotide binding] 446470004369 dimerization interface [polypeptide binding]; other site 446470004370 RibD C-terminal domain; Region: RibD_C; cl17279 446470004371 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 446470004372 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470004373 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470004374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470004375 Walker A/P-loop; other site 446470004376 ATP binding site [chemical binding]; other site 446470004377 Q-loop/lid; other site 446470004378 ABC transporter signature motif; other site 446470004379 Walker B; other site 446470004380 D-loop; other site 446470004381 H-loop/switch region; other site 446470004382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470004383 Histidine kinase; Region: HisKA_3; pfam07730 446470004384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470004385 ATP binding site [chemical binding]; other site 446470004386 Mg2+ binding site [ion binding]; other site 446470004387 G-X-G motif; other site 446470004388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470004389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470004390 active site 446470004391 phosphorylation site [posttranslational modification] 446470004392 intermolecular recognition site; other site 446470004393 dimerization interface [polypeptide binding]; other site 446470004394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470004395 DNA binding residues [nucleotide binding] 446470004396 dimerization interface [polypeptide binding]; other site 446470004397 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470004398 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470004399 putative NAD(P) binding site [chemical binding]; other site 446470004400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 446470004401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004402 metabolite-proton symporter; Region: 2A0106; TIGR00883 446470004403 putative substrate translocation pore; other site 446470004404 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446470004405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470004406 active site 446470004407 NIPSNAP; Region: NIPSNAP; pfam07978 446470004408 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470004409 HTH domain; Region: HTH_11; pfam08279 446470004410 WYL domain; Region: WYL; pfam13280 446470004411 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470004412 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470004413 YCII-related domain; Region: YCII; cl00999 446470004414 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 446470004415 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 446470004416 G1 box; other site 446470004417 putative GEF interaction site [polypeptide binding]; other site 446470004418 GTP/Mg2+ binding site [chemical binding]; other site 446470004419 Switch I region; other site 446470004420 G2 box; other site 446470004421 G3 box; other site 446470004422 Switch II region; other site 446470004423 G4 box; other site 446470004424 G5 box; other site 446470004425 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 446470004426 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 446470004427 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 446470004428 AAA ATPase domain; Region: AAA_16; pfam13191 446470004429 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470004430 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470004431 DNA binding residues [nucleotide binding] 446470004432 dimerization interface [polypeptide binding]; other site 446470004433 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446470004434 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470004435 motif 1; other site 446470004436 dimer interface [polypeptide binding]; other site 446470004437 active site 446470004438 motif 2; other site 446470004439 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 446470004440 putative deacylase active site [active] 446470004441 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470004442 active site 446470004443 motif 3; other site 446470004444 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 446470004445 anticodon binding site; other site 446470004446 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470004447 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446470004448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470004449 NAD(P) binding site [chemical binding]; other site 446470004450 active site 446470004451 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470004452 DinB superfamily; Region: DinB_2; pfam12867 446470004453 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470004454 DNA binding site [nucleotide binding] 446470004455 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470004456 NB-ARC domain; Region: NB-ARC; pfam00931 446470004457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470004458 TPR motif; other site 446470004459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004460 binding surface 446470004461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004462 AAA ATPase domain; Region: AAA_16; pfam13191 446470004463 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470004465 binding surface 446470004466 TPR motif; other site 446470004467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004468 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 446470004469 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 446470004470 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 446470004471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470004472 dimer interface [polypeptide binding]; other site 446470004473 conserved gate region; other site 446470004474 ABC-ATPase subunit interface; other site 446470004475 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 446470004476 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 446470004477 Walker A/P-loop; other site 446470004478 ATP binding site [chemical binding]; other site 446470004479 Q-loop/lid; other site 446470004480 ABC transporter signature motif; other site 446470004481 Walker B; other site 446470004482 D-loop; other site 446470004483 H-loop/switch region; other site 446470004484 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 446470004485 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446470004486 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446470004487 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446470004488 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446470004489 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446470004490 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446470004491 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446470004492 putative NADH binding site [chemical binding]; other site 446470004493 putative active site [active] 446470004494 nudix motif; other site 446470004495 putative metal binding site [ion binding]; other site 446470004496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004497 putative Zn2+ binding site [ion binding]; other site 446470004498 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470004499 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470004500 DNA binding site [nucleotide binding] 446470004501 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 446470004502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446470004503 NAD(P) binding site [chemical binding]; other site 446470004504 catalytic residues [active] 446470004505 Protein of unknown function (DUF779); Region: DUF779; cl01432 446470004506 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 446470004507 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446470004508 catalytic residues [active] 446470004509 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446470004510 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446470004511 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446470004512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470004515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004516 putative substrate translocation pore; other site 446470004517 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 446470004518 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 446470004519 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 446470004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004521 S-adenosylmethionine binding site [chemical binding]; other site 446470004522 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 446470004523 Protein kinase domain; Region: Pkinase; pfam00069 446470004524 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470004525 active site 446470004526 ATP binding site [chemical binding]; other site 446470004527 substrate binding site [chemical binding]; other site 446470004528 activation loop (A-loop); other site 446470004529 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446470004530 metal ion-dependent adhesion site (MIDAS); other site 446470004531 pyruvate phosphate dikinase; Provisional; Region: PRK09279 446470004532 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446470004533 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446470004534 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446470004535 CHC2 zinc finger; Region: zf-CHC2; cl17510 446470004536 DNA primase, catalytic core; Region: dnaG; TIGR01391 446470004537 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446470004538 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446470004539 active site 446470004540 metal binding site [ion binding]; metal-binding site 446470004541 interdomain interaction site; other site 446470004542 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446470004543 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 446470004544 nodulation ABC transporter NodI; Provisional; Region: PRK13537 446470004545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470004546 Walker A/P-loop; other site 446470004547 ATP binding site [chemical binding]; other site 446470004548 Q-loop/lid; other site 446470004549 ABC transporter signature motif; other site 446470004550 Walker B; other site 446470004551 D-loop; other site 446470004552 H-loop/switch region; other site 446470004553 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470004554 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446470004555 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470004556 Trehalose utilisation; Region: ThuA; pfam06283 446470004557 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 446470004558 active site 446470004559 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470004560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470004561 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470004562 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470004563 active site 446470004564 ATP binding site [chemical binding]; other site 446470004565 substrate binding site [chemical binding]; other site 446470004566 activation loop (A-loop); other site 446470004567 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470004568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004569 S-adenosylmethionine binding site [chemical binding]; other site 446470004570 Domain of unknown function (DUF389); Region: DUF389; cl00781 446470004571 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446470004572 homotrimer interaction site [polypeptide binding]; other site 446470004573 putative active site [active] 446470004574 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446470004575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446470004576 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446470004577 catalytic residue [active] 446470004578 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446470004579 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446470004580 metal binding site [ion binding]; metal-binding site 446470004581 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 446470004582 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446470004583 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 446470004584 FAD binding site [chemical binding]; other site 446470004585 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 446470004586 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 446470004587 Potassium binding sites [ion binding]; other site 446470004588 Cesium cation binding sites [ion binding]; other site 446470004589 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446470004590 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470004591 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470004592 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446470004593 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446470004594 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 446470004595 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446470004596 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446470004597 Ligand binding site [chemical binding]; other site 446470004598 Electron transfer flavoprotein domain; Region: ETF; pfam01012 446470004599 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446470004600 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446470004601 Ligand Binding Site [chemical binding]; other site 446470004602 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446470004603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446470004604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004605 putative DNA binding site [nucleotide binding]; other site 446470004606 putative Zn2+ binding site [ion binding]; other site 446470004607 Bacterial transcriptional regulator; Region: IclR; pfam01614 446470004608 Bax inhibitor 1 like; Region: BaxI_1; cl17691 446470004609 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470004610 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446470004611 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446470004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470004613 putative PBP binding loops; other site 446470004614 dimer interface [polypeptide binding]; other site 446470004615 ABC-ATPase subunit interface; other site 446470004616 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470004617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470004618 dimer interface [polypeptide binding]; other site 446470004619 conserved gate region; other site 446470004620 putative PBP binding loops; other site 446470004621 ABC-ATPase subunit interface; other site 446470004622 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470004623 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004624 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004625 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 446470004626 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 446470004627 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 446470004628 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470004629 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004630 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470004631 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470004632 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446470004633 catalytic core [active] 446470004634 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 446470004635 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 446470004636 gamma subunit interface [polypeptide binding]; other site 446470004637 epsilon subunit interface [polypeptide binding]; other site 446470004638 LBP interface [polypeptide binding]; other site 446470004639 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446470004640 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470004641 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446470004642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470004643 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470004644 Walker A/P-loop; other site 446470004645 ATP binding site [chemical binding]; other site 446470004646 Q-loop/lid; other site 446470004647 ABC transporter signature motif; other site 446470004648 Walker B; other site 446470004649 D-loop; other site 446470004650 H-loop/switch region; other site 446470004651 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 446470004652 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446470004653 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446470004654 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470004655 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470004656 Cytochrome P450; Region: p450; cl12078 446470004657 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446470004658 Protein of unknown function DUF58; Region: DUF58; pfam01882 446470004659 MoxR-like ATPases [General function prediction only]; Region: COG0714 446470004660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470004661 Walker A motif; other site 446470004662 ATP binding site [chemical binding]; other site 446470004663 Walker B motif; other site 446470004664 arginine finger; other site 446470004665 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 446470004666 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 446470004667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470004668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470004669 active site 446470004670 phosphorylation site [posttranslational modification] 446470004671 intermolecular recognition site; other site 446470004672 dimerization interface [polypeptide binding]; other site 446470004673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470004674 DNA binding site [nucleotide binding] 446470004675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470004676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470004677 dimerization interface [polypeptide binding]; other site 446470004678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470004679 dimer interface [polypeptide binding]; other site 446470004680 phosphorylation site [posttranslational modification] 446470004681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470004682 ATP binding site [chemical binding]; other site 446470004683 Mg2+ binding site [ion binding]; other site 446470004684 G-X-G motif; other site 446470004685 lipoprotein LpqB; Provisional; Region: PRK13616 446470004686 Sporulation and spore germination; Region: Germane; pfam10646 446470004687 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 446470004688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470004689 active site 446470004690 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 446470004691 30S subunit binding site; other site 446470004692 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446470004693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470004694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470004695 Coenzyme A binding pocket [chemical binding]; other site 446470004696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470004697 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470004698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470004699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470004700 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470004701 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446470004702 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446470004703 ATP binding site [chemical binding]; other site 446470004704 putative Mg++ binding site [ion binding]; other site 446470004705 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 446470004706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 446470004707 nucleotide binding region [chemical binding]; other site 446470004708 SEC-C motif; Region: SEC-C; pfam02810 446470004709 pentatricopeptide (PPR) repeat-containing protein; Provisional; Region: PLN03081 446470004710 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446470004711 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 446470004712 NAD(P) binding site [chemical binding]; other site 446470004713 catalytic residues [active] 446470004714 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 446470004715 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470004716 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470004717 active site 446470004718 ATP binding site [chemical binding]; other site 446470004719 substrate binding site [chemical binding]; other site 446470004720 activation loop (A-loop); other site 446470004721 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470004722 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446470004723 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446470004724 RF-1 domain; Region: RF-1; pfam00472 446470004725 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446470004726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470004727 Walker A/P-loop; other site 446470004728 ATP binding site [chemical binding]; other site 446470004729 Q-loop/lid; other site 446470004730 ABC transporter signature motif; other site 446470004731 Walker B; other site 446470004732 D-loop; other site 446470004733 H-loop/switch region; other site 446470004734 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 446470004735 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 446470004736 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470004737 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470004738 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446470004739 SmpB-tmRNA interface; other site 446470004740 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 446470004741 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 446470004742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004743 dimerization interface [polypeptide binding]; other site 446470004744 putative DNA binding site [nucleotide binding]; other site 446470004745 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470004746 putative Zn2+ binding site [ion binding]; other site 446470004747 AsnC family; Region: AsnC_trans_reg; pfam01037 446470004748 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446470004749 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470004750 NB-ARC domain; Region: NB-ARC; pfam00931 446470004751 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470004753 TPR motif; other site 446470004754 binding surface 446470004755 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470004756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470004757 binding surface 446470004758 TPR motif; other site 446470004759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470004760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470004761 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470004762 dimerization interface [polypeptide binding]; other site 446470004763 substrate binding pocket [chemical binding]; other site 446470004764 Cupin domain; Region: Cupin_2; pfam07883 446470004765 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446470004766 metal binding site 2 [ion binding]; metal-binding site 446470004767 putative DNA binding helix; other site 446470004768 metal binding site 1 [ion binding]; metal-binding site 446470004769 dimer interface [polypeptide binding]; other site 446470004770 structural Zn2+ binding site [ion binding]; other site 446470004771 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 446470004772 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 446470004773 dimer interface [polypeptide binding]; other site 446470004774 active site 446470004775 heme binding site [chemical binding]; other site 446470004776 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 446470004777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470004778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470004779 active site 446470004780 phosphorylation site [posttranslational modification] 446470004781 intermolecular recognition site; other site 446470004782 dimerization interface [polypeptide binding]; other site 446470004783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470004784 DNA binding residues [nucleotide binding] 446470004785 dimerization interface [polypeptide binding]; other site 446470004786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470004787 Histidine kinase; Region: HisKA_3; pfam07730 446470004788 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470004789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470004790 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470004791 Walker A/P-loop; other site 446470004792 ATP binding site [chemical binding]; other site 446470004793 Q-loop/lid; other site 446470004794 ABC transporter signature motif; other site 446470004795 Walker B; other site 446470004796 D-loop; other site 446470004797 H-loop/switch region; other site 446470004798 FtsX-like permease family; Region: FtsX; pfam02687 446470004799 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446470004800 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470004801 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446470004802 FtsX-like permease family; Region: FtsX; pfam02687 446470004803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004804 dimerization interface [polypeptide binding]; other site 446470004805 putative DNA binding site [nucleotide binding]; other site 446470004806 putative Zn2+ binding site [ion binding]; other site 446470004807 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470004808 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 446470004809 P-loop motif; other site 446470004810 ATP binding site [chemical binding]; other site 446470004811 Chloramphenicol (Cm) binding site [chemical binding]; other site 446470004812 catalytic residue [active] 446470004813 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446470004814 putative active site [active] 446470004815 putative metal binding site [ion binding]; other site 446470004816 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470004817 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446470004818 chromosome segregation protein; Provisional; Region: PRK02224 446470004819 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 446470004820 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 446470004821 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 446470004822 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446470004823 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446470004824 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 446470004825 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 446470004826 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 446470004827 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446470004828 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446470004829 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446470004830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470004831 catalytic residue [active] 446470004832 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470004833 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446470004834 inhibitor-cofactor binding pocket; inhibition site 446470004835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470004836 catalytic residue [active] 446470004837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470004838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470004839 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470004840 putative dimerization interface [polypeptide binding]; other site 446470004841 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 446470004842 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 446470004843 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 446470004844 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470004845 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470004846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470004847 Walker A/P-loop; other site 446470004848 ATP binding site [chemical binding]; other site 446470004849 Q-loop/lid; other site 446470004850 ABC transporter signature motif; other site 446470004851 Walker B; other site 446470004852 D-loop; other site 446470004853 H-loop/switch region; other site 446470004854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470004855 Histidine kinase; Region: HisKA_3; pfam07730 446470004856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470004857 ATP binding site [chemical binding]; other site 446470004858 Mg2+ binding site [ion binding]; other site 446470004859 G-X-G motif; other site 446470004860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470004861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470004862 active site 446470004863 phosphorylation site [posttranslational modification] 446470004864 intermolecular recognition site; other site 446470004865 dimerization interface [polypeptide binding]; other site 446470004866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470004867 DNA binding residues [nucleotide binding] 446470004868 dimerization interface [polypeptide binding]; other site 446470004869 RibD C-terminal domain; Region: RibD_C; cl17279 446470004870 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470004871 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470004872 putative NAD(P) binding site [chemical binding]; other site 446470004873 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 446470004874 aromatic arch; other site 446470004875 DCoH dimer interaction site [polypeptide binding]; other site 446470004876 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446470004877 DCoH tetramer interaction site [polypeptide binding]; other site 446470004878 substrate binding site [chemical binding]; other site 446470004879 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446470004880 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446470004881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446470004882 putative amidase; Provisional; Region: PRK06169 446470004883 Amidase; Region: Amidase; pfam01425 446470004884 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 446470004885 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446470004886 NAD binding site [chemical binding]; other site 446470004887 ligand binding site [chemical binding]; other site 446470004888 catalytic site [active] 446470004889 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446470004890 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446470004891 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446470004892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470004893 DNA-binding site [nucleotide binding]; DNA binding site 446470004894 FCD domain; Region: FCD; pfam07729 446470004895 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 446470004896 tartrate dehydrogenase; Region: TTC; TIGR02089 446470004897 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446470004898 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 446470004899 tetramerization interface [polypeptide binding]; other site 446470004900 NAD(P) binding site [chemical binding]; other site 446470004901 catalytic residues [active] 446470004902 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 446470004903 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470004904 inhibitor-cofactor binding pocket; inhibition site 446470004905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470004906 catalytic residue [active] 446470004907 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 446470004908 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 446470004909 amphipathic channel; other site 446470004910 Asn-Pro-Ala signature motifs; other site 446470004911 glycerol kinase; Provisional; Region: glpK; PRK00047 446470004912 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 446470004913 N- and C-terminal domain interface [polypeptide binding]; other site 446470004914 active site 446470004915 MgATP binding site [chemical binding]; other site 446470004916 catalytic site [active] 446470004917 metal binding site [ion binding]; metal-binding site 446470004918 putative homotetramer interface [polypeptide binding]; other site 446470004919 glycerol binding site [chemical binding]; other site 446470004920 homodimer interface [polypeptide binding]; other site 446470004921 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 446470004922 Na binding site [ion binding]; other site 446470004923 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 446470004924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446470004925 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446470004926 Probable transposase; Region: OrfB_IS605; pfam01385 446470004927 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446470004928 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 446470004929 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446470004930 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 446470004931 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 446470004932 active site 446470004933 Mn binding site [ion binding]; other site 446470004934 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 446470004935 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446470004936 amidase catalytic site [active] 446470004937 Zn binding residues [ion binding]; other site 446470004938 substrate binding site [chemical binding]; other site 446470004939 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 446470004940 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446470004941 amidase catalytic site [active] 446470004942 Zn binding residues [ion binding]; other site 446470004943 substrate binding site [chemical binding]; other site 446470004944 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446470004945 amidase catalytic site [active] 446470004946 Zn binding residues [ion binding]; other site 446470004947 substrate binding site [chemical binding]; other site 446470004948 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446470004949 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446470004950 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446470004951 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470004952 non-specific DNA interactions [nucleotide binding]; other site 446470004953 DNA binding site [nucleotide binding] 446470004954 sequence specific DNA binding site [nucleotide binding]; other site 446470004955 putative cAMP binding site [chemical binding]; other site 446470004956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470004957 nucleotide binding site [chemical binding]; other site 446470004958 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470004959 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446470004960 amidase catalytic site [active] 446470004961 Zn binding residues [ion binding]; other site 446470004962 substrate binding site [chemical binding]; other site 446470004963 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 446470004964 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446470004965 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446470004966 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446470004967 Predicted flavoprotein [General function prediction only]; Region: COG0431 446470004968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470004969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470004970 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 446470004971 MarR family; Region: MarR_2; pfam12802 446470004972 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470004973 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470004974 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446470004975 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 446470004976 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 446470004977 molybdopterin cofactor binding site [chemical binding]; other site 446470004978 substrate binding site [chemical binding]; other site 446470004979 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 446470004980 molybdopterin cofactor binding site; other site 446470004981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470004982 S-adenosylmethionine binding site [chemical binding]; other site 446470004983 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446470004984 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 446470004985 nudix motif; other site 446470004986 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470004987 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470004988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004989 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446470004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470004991 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470004992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470004993 MarR family; Region: MarR_2; pfam12802 446470004994 MarR family; Region: MarR_2; cl17246 446470004995 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446470004996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470004997 dimerization interface [polypeptide binding]; other site 446470004998 putative DNA binding site [nucleotide binding]; other site 446470004999 putative Zn2+ binding site [ion binding]; other site 446470005000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470005001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470005002 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 446470005003 putative dimer interface [polypeptide binding]; other site 446470005004 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470005005 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 446470005006 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446470005007 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446470005008 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 446470005009 dimer interface [polypeptide binding]; other site 446470005010 decamer (pentamer of dimers) interface [polypeptide binding]; other site 446470005011 catalytic triad [active] 446470005012 peroxidatic and resolving cysteines [active] 446470005013 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446470005014 CoenzymeA binding site [chemical binding]; other site 446470005015 subunit interaction site [polypeptide binding]; other site 446470005016 PHB binding site; other site 446470005017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470005018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005019 active site 446470005020 phosphorylation site [posttranslational modification] 446470005021 intermolecular recognition site; other site 446470005022 dimerization interface [polypeptide binding]; other site 446470005023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470005024 DNA binding residues [nucleotide binding] 446470005025 dimerization interface [polypeptide binding]; other site 446470005026 Histidine kinase; Region: HisKA_3; pfam07730 446470005027 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470005028 ATP binding site [chemical binding]; other site 446470005029 Mg2+ binding site [ion binding]; other site 446470005030 G-X-G motif; other site 446470005031 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470005032 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446470005033 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 446470005034 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 446470005035 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446470005036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470005037 active site 446470005038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470005039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470005040 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470005041 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 446470005042 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446470005043 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446470005044 active site 446470005045 catalytic residues [active] 446470005046 metal binding site [ion binding]; metal-binding site 446470005047 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446470005048 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446470005049 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446470005050 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446470005051 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446470005052 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446470005053 HIGH motif; other site 446470005054 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446470005055 active site 446470005056 KMSKS motif; other site 446470005057 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470005058 AAA ATPase domain; Region: AAA_16; pfam13191 446470005059 Walker A motif; other site 446470005060 ATP binding site [chemical binding]; other site 446470005061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470005062 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470005063 binding surface 446470005064 TPR motif; other site 446470005065 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470005066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470005067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470005068 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446470005069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446470005070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446470005071 Probable transposase; Region: OrfB_IS605; pfam01385 446470005072 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 446470005073 putative dimer interface [polypeptide binding]; other site 446470005074 catalytic triad [active] 446470005075 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 446470005076 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470005077 putative NAD(P) binding site [chemical binding]; other site 446470005078 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446470005079 homotrimer interaction site [polypeptide binding]; other site 446470005080 putative active site [active] 446470005081 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470005082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470005083 Coenzyme A binding pocket [chemical binding]; other site 446470005084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 446470005085 MOSC domain; Region: MOSC; pfam03473 446470005086 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 446470005087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470005088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470005089 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470005090 putative dimerization interface [polypeptide binding]; other site 446470005091 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 446470005092 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446470005093 active site 446470005094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470005095 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446470005096 substrate binding pocket [chemical binding]; other site 446470005097 substrate-Mg2+ binding site; other site 446470005098 aspartate-rich region 1; other site 446470005099 aspartate-rich region 2; other site 446470005100 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470005101 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470005102 ligand binding site [chemical binding]; other site 446470005103 flexible hinge region; other site 446470005104 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470005105 ligand binding site [chemical binding]; other site 446470005106 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446470005107 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446470005108 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446470005109 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446470005110 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446470005111 TPP-binding site; other site 446470005112 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446470005113 PYR/PP interface [polypeptide binding]; other site 446470005114 dimer interface [polypeptide binding]; other site 446470005115 TPP binding site [chemical binding]; other site 446470005116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446470005117 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446470005118 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446470005119 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446470005120 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446470005121 substrate binding pocket [chemical binding]; other site 446470005122 chain length determination region; other site 446470005123 substrate-Mg2+ binding site; other site 446470005124 catalytic residues [active] 446470005125 aspartate-rich region 1; other site 446470005126 active site lid residues [active] 446470005127 aspartate-rich region 2; other site 446470005128 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446470005129 LytB protein; Region: LYTB; cl00507 446470005130 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446470005131 Resolvase, N terminal domain; Region: Resolvase; smart00857 446470005132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470005133 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470005134 non-specific DNA binding site [nucleotide binding]; other site 446470005135 salt bridge; other site 446470005136 sequence-specific DNA binding site [nucleotide binding]; other site 446470005137 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 446470005138 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 446470005139 active site 446470005140 NTP binding site [chemical binding]; other site 446470005141 metal binding triad [ion binding]; metal-binding site 446470005142 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 446470005143 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 446470005144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470005145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470005146 DNA binding site [nucleotide binding] 446470005147 domain linker motif; other site 446470005148 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470005149 dimerization interface [polypeptide binding]; other site 446470005150 ligand binding site [chemical binding]; other site 446470005151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470005152 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470005153 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446470005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005155 dimer interface [polypeptide binding]; other site 446470005156 putative PBP binding loops; other site 446470005157 ABC-ATPase subunit interface; other site 446470005158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470005159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005160 dimer interface [polypeptide binding]; other site 446470005161 conserved gate region; other site 446470005162 putative PBP binding loops; other site 446470005163 ABC-ATPase subunit interface; other site 446470005164 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 446470005165 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446470005166 active site 446470005167 Haemolytic domain; Region: Haemolytic; cl00506 446470005168 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 446470005169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470005170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470005171 DNA binding residues [nucleotide binding] 446470005172 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446470005173 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446470005174 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446470005175 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470005176 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 446470005177 Predicted membrane protein [Function unknown]; Region: COG4325 446470005178 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 446470005179 EamA-like transporter family; Region: EamA; pfam00892 446470005180 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 446470005181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470005182 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 446470005183 acyl-activating enzyme (AAE) consensus motif; other site 446470005184 AMP binding site [chemical binding]; other site 446470005185 active site 446470005186 CoA binding site [chemical binding]; other site 446470005187 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 446470005188 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 446470005189 putative active site [active] 446470005190 putative metal binding site [ion binding]; other site 446470005191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470005192 Histidine kinase; Region: HisKA_3; pfam07730 446470005193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470005194 ATP binding site [chemical binding]; other site 446470005195 Mg2+ binding site [ion binding]; other site 446470005196 G-X-G motif; other site 446470005197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470005198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005199 active site 446470005200 phosphorylation site [posttranslational modification] 446470005201 intermolecular recognition site; other site 446470005202 dimerization interface [polypeptide binding]; other site 446470005203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470005204 DNA binding residues [nucleotide binding] 446470005205 dimerization interface [polypeptide binding]; other site 446470005206 MMPL family; Region: MMPL; pfam03176 446470005207 MMPL family; Region: MMPL; pfam03176 446470005208 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446470005209 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446470005210 Recombination protein O N terminal; Region: RecO_N; pfam11967 446470005211 Recombination protein O C terminal; Region: RecO_C; pfam02565 446470005212 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 446470005213 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446470005214 catalytic residue [active] 446470005215 putative FPP diphosphate binding site; other site 446470005216 putative FPP binding hydrophobic cleft; other site 446470005217 dimer interface [polypeptide binding]; other site 446470005218 putative IPP diphosphate binding site; other site 446470005219 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 446470005220 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446470005221 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446470005222 Walker A/P-loop; other site 446470005223 ATP binding site [chemical binding]; other site 446470005224 Q-loop/lid; other site 446470005225 ABC transporter signature motif; other site 446470005226 Walker B; other site 446470005227 D-loop; other site 446470005228 H-loop/switch region; other site 446470005229 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470005230 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446470005231 Walker A/P-loop; other site 446470005232 ATP binding site [chemical binding]; other site 446470005233 Q-loop/lid; other site 446470005234 ABC transporter signature motif; other site 446470005235 Walker B; other site 446470005236 D-loop; other site 446470005237 H-loop/switch region; other site 446470005238 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 446470005239 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446470005240 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446470005241 intersubunit interface [polypeptide binding]; other site 446470005242 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470005243 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446470005244 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446470005245 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470005246 ABC-ATPase subunit interface; other site 446470005247 dimer interface [polypeptide binding]; other site 446470005248 putative PBP binding regions; other site 446470005249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470005250 putative DNA binding site [nucleotide binding]; other site 446470005251 putative Zn2+ binding site [ion binding]; other site 446470005252 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 446470005253 AzlC protein; Region: AzlC; pfam03591 446470005254 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470005255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470005256 non-specific DNA binding site [nucleotide binding]; other site 446470005257 salt bridge; other site 446470005258 sequence-specific DNA binding site [nucleotide binding]; other site 446470005259 Cupin domain; Region: Cupin_2; cl17218 446470005260 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446470005261 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470005262 motif 1; other site 446470005263 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 446470005264 active site 446470005265 motif 2; other site 446470005266 motif 3; other site 446470005267 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 446470005268 anticodon binding site; other site 446470005269 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 446470005270 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 446470005271 FMN binding site [chemical binding]; other site 446470005272 active site 446470005273 catalytic residues [active] 446470005274 substrate binding site [chemical binding]; other site 446470005275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470005276 S-adenosylmethionine binding site [chemical binding]; other site 446470005277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470005278 Histidine kinase; Region: HisKA_3; pfam07730 446470005279 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 446470005280 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 446470005281 putative active site [active] 446470005282 catalytic site [active] 446470005283 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 446470005284 putative active site [active] 446470005285 catalytic site [active] 446470005286 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470005287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005288 active site 446470005289 phosphorylation site [posttranslational modification] 446470005290 intermolecular recognition site; other site 446470005291 dimerization interface [polypeptide binding]; other site 446470005292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470005293 DNA binding residues [nucleotide binding] 446470005294 dimerization interface [polypeptide binding]; other site 446470005295 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 446470005296 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446470005297 G1 box; other site 446470005298 GTP/Mg2+ binding site [chemical binding]; other site 446470005299 G2 box; other site 446470005300 Switch I region; other site 446470005301 G3 box; other site 446470005302 Switch II region; other site 446470005303 G4 box; other site 446470005304 G5 box; other site 446470005305 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 446470005306 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 446470005307 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 446470005308 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446470005309 Peptidase family M28; Region: Peptidase_M28; pfam04389 446470005310 active site 446470005311 metal binding site [ion binding]; metal-binding site 446470005312 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 446470005313 PQQ-like domain; Region: PQQ_2; pfam13360 446470005314 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470005315 structural tetrad; other site 446470005316 PQQ-like domain; Region: PQQ_2; pfam13360 446470005317 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 446470005318 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 446470005319 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470005320 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 446470005321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470005322 ATP binding site [chemical binding]; other site 446470005323 putative Mg++ binding site [ion binding]; other site 446470005324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470005325 nucleotide binding region [chemical binding]; other site 446470005326 ATP-binding site [chemical binding]; other site 446470005327 Helicase associated domain (HA2); Region: HA2; pfam04408 446470005328 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446470005329 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446470005330 MarR family; Region: MarR_2; pfam12802 446470005331 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446470005332 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446470005333 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470005334 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470005335 active site 446470005336 ATP binding site [chemical binding]; other site 446470005337 substrate binding site [chemical binding]; other site 446470005338 activation loop (A-loop); other site 446470005339 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470005340 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470005341 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470005342 active site 446470005343 ATP binding site [chemical binding]; other site 446470005344 substrate binding site [chemical binding]; other site 446470005345 activation loop (A-loop); other site 446470005346 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470005347 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470005348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470005349 S-adenosylmethionine binding site [chemical binding]; other site 446470005350 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470005351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470005352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470005353 Walker A/P-loop; other site 446470005354 ATP binding site [chemical binding]; other site 446470005355 Q-loop/lid; other site 446470005356 ABC transporter signature motif; other site 446470005357 Walker B; other site 446470005358 D-loop; other site 446470005359 H-loop/switch region; other site 446470005360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470005361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470005362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470005363 ABC transporter signature motif; other site 446470005364 Walker B; other site 446470005365 D-loop; other site 446470005366 H-loop/switch region; other site 446470005367 YCII-related domain; Region: YCII; cl00999 446470005368 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446470005369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470005370 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470005371 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446470005372 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446470005373 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470005374 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470005375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470005376 DNA binding residues [nucleotide binding] 446470005377 dimerization interface [polypeptide binding]; other site 446470005378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470005379 non-specific DNA binding site [nucleotide binding]; other site 446470005380 salt bridge; other site 446470005381 sequence-specific DNA binding site [nucleotide binding]; other site 446470005382 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470005383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470005384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470005385 dimerization interface [polypeptide binding]; other site 446470005386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470005387 dimer interface [polypeptide binding]; other site 446470005388 phosphorylation site [posttranslational modification] 446470005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470005390 ATP binding site [chemical binding]; other site 446470005391 Mg2+ binding site [ion binding]; other site 446470005392 G-X-G motif; other site 446470005393 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470005394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005395 active site 446470005396 phosphorylation site [posttranslational modification] 446470005397 intermolecular recognition site; other site 446470005398 dimerization interface [polypeptide binding]; other site 446470005399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470005400 DNA binding site [nucleotide binding] 446470005401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470005402 FtsX-like permease family; Region: FtsX; pfam02687 446470005403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470005404 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470005405 Walker A/P-loop; other site 446470005406 ATP binding site [chemical binding]; other site 446470005407 Q-loop/lid; other site 446470005408 ABC transporter signature motif; other site 446470005409 Walker B; other site 446470005410 D-loop; other site 446470005411 H-loop/switch region; other site 446470005412 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 446470005413 putative hydrophobic ligand binding site [chemical binding]; other site 446470005414 protein interface [polypeptide binding]; other site 446470005415 gate; other site 446470005416 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 446470005417 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 446470005418 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470005419 DinB superfamily; Region: DinB_2; pfam12867 446470005420 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470005421 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470005422 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470005423 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470005424 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446470005425 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446470005426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470005427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005428 active site 446470005429 phosphorylation site [posttranslational modification] 446470005430 intermolecular recognition site; other site 446470005431 dimerization interface [polypeptide binding]; other site 446470005432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470005433 DNA binding site [nucleotide binding] 446470005434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470005435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470005436 dimerization interface [polypeptide binding]; other site 446470005437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470005438 dimer interface [polypeptide binding]; other site 446470005439 phosphorylation site [posttranslational modification] 446470005440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470005441 ATP binding site [chemical binding]; other site 446470005442 Mg2+ binding site [ion binding]; other site 446470005443 G-X-G motif; other site 446470005444 TM1410 hypothetical-related protein; Region: DUF297; cl00997 446470005445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470005446 putative DNA binding site [nucleotide binding]; other site 446470005447 dimerization interface [polypeptide binding]; other site 446470005448 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470005449 putative Zn2+ binding site [ion binding]; other site 446470005450 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446470005451 AsnC family; Region: AsnC_trans_reg; pfam01037 446470005452 thiamine monophosphate kinase; Provisional; Region: PRK05731 446470005453 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446470005454 ATP binding site [chemical binding]; other site 446470005455 dimerization interface [polypeptide binding]; other site 446470005456 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446470005457 Sec24-related protein; Provisional; Region: PTZ00395 446470005458 DAK2 domain; Region: Dak2; pfam02734 446470005459 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 446470005460 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446470005461 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446470005462 generic binding surface II; other site 446470005463 ssDNA binding site; other site 446470005464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470005465 ATP binding site [chemical binding]; other site 446470005466 putative Mg++ binding site [ion binding]; other site 446470005467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470005468 nucleotide binding region [chemical binding]; other site 446470005469 ATP-binding site [chemical binding]; other site 446470005470 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 446470005471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470005472 S-adenosylmethionine binding site [chemical binding]; other site 446470005473 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 446470005474 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 446470005475 active site 446470005476 (T/H)XGH motif; other site 446470005477 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 446470005478 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 446470005479 ribonuclease III; Reviewed; Region: rnc; PRK00102 446470005480 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 446470005481 dimerization interface [polypeptide binding]; other site 446470005482 active site 446470005483 metal binding site [ion binding]; metal-binding site 446470005484 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446470005485 dsRNA binding site [nucleotide binding]; other site 446470005486 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446470005487 AAA domain; Region: AAA_23; pfam13476 446470005488 Walker A/P-loop; other site 446470005489 ATP binding site [chemical binding]; other site 446470005490 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 446470005491 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446470005492 ABC transporter signature motif; other site 446470005493 Walker B; other site 446470005494 D-loop; other site 446470005495 H-loop/switch region; other site 446470005496 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 446470005497 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 446470005498 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446470005499 Phosphotransferase enzyme family; Region: APH; pfam01636 446470005500 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470005501 active site 446470005502 ATP binding site [chemical binding]; other site 446470005503 substrate binding site [chemical binding]; other site 446470005504 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 446470005505 hypothetical protein; Provisional; Region: PRK06126 446470005506 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470005507 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470005508 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446470005509 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470005510 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470005511 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470005512 active site 446470005513 ATP binding site [chemical binding]; other site 446470005514 substrate binding site [chemical binding]; other site 446470005515 activation loop (A-loop); other site 446470005516 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470005517 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446470005518 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446470005519 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446470005520 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446470005521 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446470005522 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446470005523 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446470005524 putative substrate binding site [chemical binding]; other site 446470005525 putative ATP binding site [chemical binding]; other site 446470005526 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 446470005527 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 446470005528 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 446470005529 active site 446470005530 P-loop; other site 446470005531 phosphorylation site [posttranslational modification] 446470005532 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446470005533 active site 446470005534 phosphorylation site [posttranslational modification] 446470005535 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446470005536 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 446470005537 putative NAD(P) binding site [chemical binding]; other site 446470005538 catalytic Zn binding site [ion binding]; other site 446470005539 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446470005540 dimerization domain swap beta strand [polypeptide binding]; other site 446470005541 regulatory protein interface [polypeptide binding]; other site 446470005542 active site 446470005543 regulatory phosphorylation site [posttranslational modification]; other site 446470005544 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446470005545 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446470005546 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446470005547 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446470005548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470005549 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470005550 active site 446470005551 ATP binding site [chemical binding]; other site 446470005552 substrate binding site [chemical binding]; other site 446470005553 activation loop (A-loop); other site 446470005554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470005555 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446470005556 Part of AAA domain; Region: AAA_19; pfam13245 446470005557 DinB superfamily; Region: DinB_2; pfam12867 446470005558 Predicted membrane protein [Function unknown]; Region: COG2311 446470005559 Protein of unknown function (DUF418); Region: DUF418; cl12135 446470005560 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470005561 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 446470005562 Family description; Region: VCBS; pfam13517 446470005563 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 446470005564 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 446470005565 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446470005566 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446470005567 Clp amino terminal domain; Region: Clp_N; pfam02861 446470005568 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446470005569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446470005570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470005571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470005572 Coenzyme A binding pocket [chemical binding]; other site 446470005573 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446470005574 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 446470005575 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446470005576 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470005577 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 446470005578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470005579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446470005580 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446470005581 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470005582 active site 446470005583 metal binding site [ion binding]; metal-binding site 446470005584 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 446470005585 Protein of unknown function (DUF952); Region: DUF952; cl01393 446470005586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470005588 putative substrate translocation pore; other site 446470005589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470005590 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 446470005591 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 446470005592 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 446470005593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470005594 FeS/SAM binding site; other site 446470005595 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 446470005596 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 446470005597 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 446470005598 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 446470005599 prolyl-tRNA synthetase; Provisional; Region: PRK08661 446470005600 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 446470005601 dimer interface [polypeptide binding]; other site 446470005602 motif 1; other site 446470005603 active site 446470005604 motif 2; other site 446470005605 motif 3; other site 446470005606 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 446470005607 anticodon binding site; other site 446470005608 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 446470005609 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 446470005610 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 446470005611 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446470005612 RimM N-terminal domain; Region: RimM; pfam01782 446470005613 PRC-barrel domain; Region: PRC; pfam05239 446470005614 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 446470005615 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 446470005616 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446470005617 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446470005618 Catalytic site [active] 446470005619 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446470005620 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446470005621 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446470005622 Catalytic site [active] 446470005623 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446470005624 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446470005625 Catalytic site [active] 446470005626 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446470005627 RNA/DNA hybrid binding site [nucleotide binding]; other site 446470005628 active site 446470005629 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446470005630 DNA protecting protein DprA; Region: dprA; TIGR00732 446470005631 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446470005632 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446470005633 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446470005634 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446470005635 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 446470005636 hypothetical protein; Reviewed; Region: PRK12497 446470005637 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446470005638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470005639 active site 446470005640 DNA binding site [nucleotide binding] 446470005641 Int/Topo IB signature motif; other site 446470005642 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446470005643 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470005644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470005645 catalytic residue [active] 446470005646 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446470005647 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446470005648 rRNA interaction site [nucleotide binding]; other site 446470005649 S8 interaction site; other site 446470005650 putative laminin-1 binding site; other site 446470005651 elongation factor Ts; Provisional; Region: tsf; PRK09377 446470005652 UBA/TS-N domain; Region: UBA; pfam00627 446470005653 Elongation factor TS; Region: EF_TS; pfam00889 446470005654 Elongation factor TS; Region: EF_TS; pfam00889 446470005655 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 446470005656 putative nucleotide binding site [chemical binding]; other site 446470005657 uridine monophosphate binding site [chemical binding]; other site 446470005658 homohexameric interface [polypeptide binding]; other site 446470005659 ribosome recycling factor; Reviewed; Region: frr; PRK00083 446470005660 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 446470005661 hinge region; other site 446470005662 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 446470005663 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 446470005664 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 446470005665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470005666 FeS/SAM binding site; other site 446470005667 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470005668 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470005669 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 446470005670 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446470005671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446470005672 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446470005673 iron-sulfur cluster [ion binding]; other site 446470005674 [2Fe-2S] cluster binding site [ion binding]; other site 446470005675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470005676 non-specific DNA binding site [nucleotide binding]; other site 446470005677 sequence-specific DNA binding site [nucleotide binding]; other site 446470005678 salt bridge; other site 446470005679 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470005680 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470005681 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 446470005682 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 446470005683 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446470005684 Predicted membrane protein [Function unknown]; Region: COG1950 446470005685 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 446470005686 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 446470005687 Walker A/P-loop; other site 446470005688 ATP binding site [chemical binding]; other site 446470005689 Q-loop/lid; other site 446470005690 ABC transporter signature motif; other site 446470005691 Walker B; other site 446470005692 D-loop; other site 446470005693 H-loop/switch region; other site 446470005694 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 446470005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005696 dimer interface [polypeptide binding]; other site 446470005697 conserved gate region; other site 446470005698 putative PBP binding loops; other site 446470005699 ABC-ATPase subunit interface; other site 446470005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005701 dimer interface [polypeptide binding]; other site 446470005702 conserved gate region; other site 446470005703 putative PBP binding loops; other site 446470005704 ABC-ATPase subunit interface; other site 446470005705 PBP superfamily domain; Region: PBP_like_2; cl17296 446470005706 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446470005707 PhoU domain; Region: PhoU; pfam01895 446470005708 PhoU domain; Region: PhoU; pfam01895 446470005709 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 446470005710 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446470005711 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446470005712 putative hydrophobic ligand binding site [chemical binding]; other site 446470005713 Predicted transcriptional regulators [Transcription]; Region: COG1725 446470005714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470005715 DNA-binding site [nucleotide binding]; DNA binding site 446470005716 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470005717 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470005718 Walker A/P-loop; other site 446470005719 ATP binding site [chemical binding]; other site 446470005720 Q-loop/lid; other site 446470005721 ABC transporter signature motif; other site 446470005722 Walker B; other site 446470005723 D-loop; other site 446470005724 H-loop/switch region; other site 446470005725 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 446470005726 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470005727 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446470005728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470005729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470005730 Coenzyme A binding pocket [chemical binding]; other site 446470005731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 446470005732 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446470005733 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 446470005734 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 446470005735 Protein kinase domain; Region: Pkinase; pfam00069 446470005736 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470005737 active site 446470005738 ATP binding site [chemical binding]; other site 446470005739 substrate binding site [chemical binding]; other site 446470005740 activation loop (A-loop); other site 446470005741 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 446470005742 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470005743 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470005744 MarR family; Region: MarR_2; pfam12802 446470005745 Cupin domain; Region: Cupin_2; pfam07883 446470005746 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470005747 putative catalytic site [active] 446470005748 putative metal binding site [ion binding]; other site 446470005749 putative phosphate binding site [ion binding]; other site 446470005750 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 446470005751 signal recognition particle protein; Provisional; Region: PRK10867 446470005752 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 446470005753 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446470005754 P loop; other site 446470005755 GTP binding site [chemical binding]; other site 446470005756 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446470005757 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446470005758 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470005759 active site 446470005760 Rhomboid family; Region: Rhomboid; pfam01694 446470005761 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470005762 FtsX-like permease family; Region: FtsX; pfam02687 446470005763 FtsX-like permease family; Region: FtsX; pfam02687 446470005764 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470005765 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470005766 Walker A/P-loop; other site 446470005767 ATP binding site [chemical binding]; other site 446470005768 Q-loop/lid; other site 446470005769 ABC transporter signature motif; other site 446470005770 Walker B; other site 446470005771 D-loop; other site 446470005772 H-loop/switch region; other site 446470005773 Putative sensor; Region: Sensor; pfam13796 446470005774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470005775 Histidine kinase; Region: HisKA_3; pfam07730 446470005776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470005777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005778 active site 446470005779 phosphorylation site [posttranslational modification] 446470005780 intermolecular recognition site; other site 446470005781 dimerization interface [polypeptide binding]; other site 446470005782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470005783 DNA binding residues [nucleotide binding] 446470005784 Histidine kinase; Region: HisKA_3; pfam07730 446470005785 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470005786 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470005787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470005788 S-adenosylmethionine binding site [chemical binding]; other site 446470005789 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470005790 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 446470005791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470005792 dimerization interface [polypeptide binding]; other site 446470005793 putative DNA binding site [nucleotide binding]; other site 446470005794 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470005795 putative Zn2+ binding site [ion binding]; other site 446470005796 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470005797 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470005798 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 446470005799 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446470005800 active site 446470005801 catalytic triad [active] 446470005802 oxyanion hole [active] 446470005803 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 446470005804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470005805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005806 dimer interface [polypeptide binding]; other site 446470005807 conserved gate region; other site 446470005808 putative PBP binding loops; other site 446470005809 ABC-ATPase subunit interface; other site 446470005810 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 446470005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005812 dimer interface [polypeptide binding]; other site 446470005813 conserved gate region; other site 446470005814 putative PBP binding loops; other site 446470005815 ABC-ATPase subunit interface; other site 446470005816 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470005817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446470005818 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 446470005819 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446470005820 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446470005821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470005822 nucleotide binding site [chemical binding]; other site 446470005823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470005824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470005825 DNA binding site [nucleotide binding] 446470005826 domain linker motif; other site 446470005827 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470005828 dimerization interface [polypeptide binding]; other site 446470005829 ligand binding site [chemical binding]; other site 446470005830 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 446470005831 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 446470005832 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 446470005833 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446470005834 TIGR03086 family protein; Region: TIGR03086 446470005835 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470005836 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470005837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470005838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470005839 DNA binding residues [nucleotide binding] 446470005840 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 446470005841 active site 446470005842 catalytic triad [active] 446470005843 oxyanion hole [active] 446470005844 RibD C-terminal domain; Region: RibD_C; cl17279 446470005845 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470005846 cleavage site 446470005847 active site 446470005848 substrate binding sites [chemical binding]; other site 446470005849 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 446470005850 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 446470005851 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446470005852 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446470005853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470005854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470005855 putative substrate translocation pore; other site 446470005856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446470005857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470005858 dimerization interface [polypeptide binding]; other site 446470005859 putative DNA binding site [nucleotide binding]; other site 446470005860 putative Zn2+ binding site [ion binding]; other site 446470005861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470005862 dimerization interface [polypeptide binding]; other site 446470005863 putative DNA binding site [nucleotide binding]; other site 446470005864 putative Zn2+ binding site [ion binding]; other site 446470005865 Domain of unknown function (DU1801); Region: DUF1801; cl17490 446470005866 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 446470005867 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446470005868 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 446470005869 Cupin; Region: Cupin_6; pfam12852 446470005870 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446470005871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470005872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470005873 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 446470005874 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 446470005875 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446470005876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470005877 Walker A/P-loop; other site 446470005878 ATP binding site [chemical binding]; other site 446470005879 Q-loop/lid; other site 446470005880 ABC transporter signature motif; other site 446470005881 Walker B; other site 446470005882 D-loop; other site 446470005883 H-loop/switch region; other site 446470005884 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470005885 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470005886 DNA binding site [nucleotide binding] 446470005887 domain linker motif; other site 446470005888 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470005889 ligand binding site [chemical binding]; other site 446470005890 dimerization interface [polypeptide binding]; other site 446470005891 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446470005892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005893 dimer interface [polypeptide binding]; other site 446470005894 putative PBP binding loops; other site 446470005895 ABC-ATPase subunit interface; other site 446470005896 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470005897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470005898 ABC-ATPase subunit interface; other site 446470005899 putative PBP binding loops; other site 446470005900 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470005901 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470005902 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446470005903 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446470005904 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 446470005905 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470005906 substrate binding site [chemical binding]; other site 446470005907 dimer interface [polypeptide binding]; other site 446470005908 ATP binding site [chemical binding]; other site 446470005909 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446470005910 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470005911 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470005912 MarR family; Region: MarR; pfam01047 446470005913 MarR family; Region: MarR_2; cl17246 446470005914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470005915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470005916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470005917 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 446470005918 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470005919 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470005920 DNA binding residues [nucleotide binding] 446470005921 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470005922 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470005923 putative acyl-acceptor binding pocket; other site 446470005924 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 446470005925 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470005926 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470005927 putative NAD(P) binding site [chemical binding]; other site 446470005928 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470005929 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470005930 Phosphotransferase enzyme family; Region: APH; pfam01636 446470005931 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470005932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470005933 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470005934 NAD(P) binding site [chemical binding]; other site 446470005935 active site 446470005936 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 446470005937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470005938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470005939 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 446470005940 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470005941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470005942 putative substrate translocation pore; other site 446470005943 metal-dependent hydrolase; Provisional; Region: PRK13291 446470005944 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 446470005945 putative DNA binding site [nucleotide binding]; other site 446470005946 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 446470005947 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446470005948 Bacterial transcriptional regulator; Region: IclR; pfam01614 446470005949 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446470005950 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446470005951 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446470005952 tetramer interface [polypeptide binding]; other site 446470005953 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 446470005954 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 446470005955 active site 446470005956 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 446470005957 heterodimer interface [polypeptide binding]; other site 446470005958 multimer interface [polypeptide binding]; other site 446470005959 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 446470005960 active site 446470005961 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 446470005962 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 446470005963 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446470005964 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446470005965 NAD(P) binding site [chemical binding]; other site 446470005966 catalytic residues [active] 446470005967 NMT1-like family; Region: NMT1_2; pfam13379 446470005968 NMT1/THI5 like; Region: NMT1; pfam09084 446470005969 membrane-bound complex binding site; other site 446470005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446470005971 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446470005972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446470005973 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446470005974 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446470005975 Walker A/P-loop; other site 446470005976 ATP binding site [chemical binding]; other site 446470005977 Q-loop/lid; other site 446470005978 ABC transporter signature motif; other site 446470005979 Walker B; other site 446470005980 D-loop; other site 446470005981 H-loop/switch region; other site 446470005982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 446470005983 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 446470005984 acyl-activating enzyme (AAE) consensus motif; other site 446470005985 putative AMP binding site [chemical binding]; other site 446470005986 putative active site [active] 446470005987 putative CoA binding site [chemical binding]; other site 446470005988 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470005989 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470005990 active site 446470005991 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470005992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470005993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470005994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470005995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470005996 active site 446470005997 phosphorylation site [posttranslational modification] 446470005998 intermolecular recognition site; other site 446470005999 dimerization interface [polypeptide binding]; other site 446470006000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470006001 DNA binding residues [nucleotide binding] 446470006002 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446470006003 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446470006004 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446470006005 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446470006006 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446470006007 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446470006008 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446470006009 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446470006010 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 446470006011 active site clefts [active] 446470006012 zinc binding site [ion binding]; other site 446470006013 dimer interface [polypeptide binding]; other site 446470006014 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446470006015 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446470006016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470006017 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446470006018 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 446470006019 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 446470006020 TMP-binding site; other site 446470006021 ATP-binding site [chemical binding]; other site 446470006022 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446470006023 Ligand binding site [chemical binding]; other site 446470006024 Electron transfer flavoprotein domain; Region: ETF; pfam01012 446470006025 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446470006026 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 446470006027 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446470006028 BioY family; Region: BioY; pfam02632 446470006029 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470006030 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470006031 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470006032 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470006033 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446470006034 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446470006035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470006036 catalytic residue [active] 446470006037 short chain dehydrogenase; Provisional; Region: PRK06523 446470006038 classical (c) SDRs; Region: SDR_c; cd05233 446470006039 NAD(P) binding site [chemical binding]; other site 446470006040 active site 446470006041 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 446470006042 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 446470006043 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 446470006044 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 446470006045 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446470006046 nucleotide binding pocket [chemical binding]; other site 446470006047 K-X-D-G motif; other site 446470006048 catalytic site [active] 446470006049 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446470006050 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446470006051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470006052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470006053 metal binding site [ion binding]; metal-binding site 446470006054 active site 446470006055 I-site; other site 446470006056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446470006057 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 446470006058 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446470006059 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 446470006060 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446470006061 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446470006062 GatB domain; Region: GatB_Yqey; smart00845 446470006063 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446470006064 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 446470006065 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 446470006066 putative active site [active] 446470006067 putative substrate binding site [chemical binding]; other site 446470006068 putative FMN binding site [chemical binding]; other site 446470006069 putative catalytic residues [active] 446470006070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470006071 Coenzyme A binding pocket [chemical binding]; other site 446470006072 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 446470006073 active site 446470006074 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470006075 substrate binding site [chemical binding]; other site 446470006076 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 446470006077 oxyanion hole (OAH) forming residues; other site 446470006078 trimer interface [polypeptide binding]; other site 446470006079 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446470006080 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470006081 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470006082 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446470006083 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446470006084 dimer interface [polypeptide binding]; other site 446470006085 active site 446470006086 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 446470006087 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446470006088 catalytic site [active] 446470006089 putative active site [active] 446470006090 putative substrate binding site [chemical binding]; other site 446470006091 HRDC domain; Region: HRDC; pfam00570 446470006092 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470006093 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470006094 DNA binding residues [nucleotide binding] 446470006095 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 446470006096 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 446470006097 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446470006098 metal ion-dependent adhesion site (MIDAS); other site 446470006099 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446470006100 homotrimer interaction site [polypeptide binding]; other site 446470006101 putative active site [active] 446470006102 Protein of unknown function (DUF402); Region: DUF402; pfam04167 446470006103 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470006104 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470006105 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470006106 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470006107 DinB superfamily; Region: DinB_2; pfam12867 446470006108 hypothetical protein; Provisional; Region: PRK01346 446470006109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 446470006110 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446470006111 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 446470006112 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446470006113 active site 446470006114 dimer interface [polypeptide binding]; other site 446470006115 motif 1; other site 446470006116 motif 2; other site 446470006117 motif 3; other site 446470006118 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 446470006119 anticodon binding site; other site 446470006120 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446470006121 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446470006122 NAD(P) binding site [chemical binding]; other site 446470006123 catalytic residues [active] 446470006124 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 446470006125 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446470006126 Walker A/P-loop; other site 446470006127 ATP binding site [chemical binding]; other site 446470006128 Q-loop/lid; other site 446470006129 ABC transporter signature motif; other site 446470006130 Walker B; other site 446470006131 D-loop; other site 446470006132 H-loop/switch region; other site 446470006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470006134 dimer interface [polypeptide binding]; other site 446470006135 conserved gate region; other site 446470006136 putative PBP binding loops; other site 446470006137 ABC-ATPase subunit interface; other site 446470006138 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 446470006139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470006140 dimer interface [polypeptide binding]; other site 446470006141 conserved gate region; other site 446470006142 putative PBP binding loops; other site 446470006143 ABC-ATPase subunit interface; other site 446470006144 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 446470006145 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446470006146 choline dehydrogenase; Validated; Region: PRK02106 446470006147 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446470006148 potassium/proton antiporter; Reviewed; Region: PRK05326 446470006149 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446470006150 TrkA-C domain; Region: TrkA_C; pfam02080 446470006151 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446470006152 nucleotide binding site/active site [active] 446470006153 HIT family signature motif; other site 446470006154 catalytic residue [active] 446470006155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470006156 NmrA-like family; Region: NmrA; pfam05368 446470006157 NAD(P) binding site [chemical binding]; other site 446470006158 active site 446470006159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006161 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 446470006162 elongation factor G; Reviewed; Region: PRK12740 446470006163 G1 box; other site 446470006164 putative GEF interaction site [polypeptide binding]; other site 446470006165 GTP/Mg2+ binding site [chemical binding]; other site 446470006166 Switch I region; other site 446470006167 G2 box; other site 446470006168 G3 box; other site 446470006169 Switch II region; other site 446470006170 G4 box; other site 446470006171 G5 box; other site 446470006172 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446470006173 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446470006174 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446470006175 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446470006176 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 446470006177 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 446470006178 putative acyl-acceptor binding pocket; other site 446470006179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470006180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446470006181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470006182 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446470006183 putative ADP-binding pocket [chemical binding]; other site 446470006184 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 446470006185 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 446470006186 active site 446470006187 multimer interface [polypeptide binding]; other site 446470006188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470006189 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470006190 binding surface 446470006191 TPR motif; other site 446470006192 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470006193 tyrosine decarboxylase; Region: PLN02880 446470006194 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470006195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470006196 catalytic residue [active] 446470006197 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 446470006198 heme-binding site [chemical binding]; other site 446470006199 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446470006200 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446470006201 putative active site [active] 446470006202 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 446470006203 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 446470006204 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446470006205 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446470006206 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446470006207 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 446470006208 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446470006209 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446470006210 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446470006211 putative active site [active] 446470006212 transaldolase; Provisional; Region: PRK03903 446470006213 catalytic residue [active] 446470006214 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 446470006215 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446470006216 TPP-binding site [chemical binding]; other site 446470006217 dimer interface [polypeptide binding]; other site 446470006218 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446470006219 PYR/PP interface [polypeptide binding]; other site 446470006220 dimer interface [polypeptide binding]; other site 446470006221 TPP binding site [chemical binding]; other site 446470006222 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446470006223 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 446470006224 UbiA prenyltransferase family; Region: UbiA; pfam01040 446470006225 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446470006226 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470006227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470006228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470006229 DNA binding residues [nucleotide binding] 446470006230 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 446470006231 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446470006232 CAAX protease self-immunity; Region: Abi; pfam02517 446470006233 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470006234 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 446470006235 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446470006236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006238 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446470006239 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446470006240 metal binding site [ion binding]; metal-binding site 446470006241 dimer interface [polypeptide binding]; other site 446470006242 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 446470006243 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446470006244 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 446470006245 Na binding site [ion binding]; other site 446470006246 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 446470006247 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 446470006248 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446470006249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470006250 catalytic residue [active] 446470006251 dimer interface [polypeptide binding]; other site 446470006252 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446470006253 tetramer interface [polypeptide binding]; other site 446470006254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470006255 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446470006256 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 446470006257 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 446470006258 putative active site [active] 446470006259 putative cosubstrate binding site; other site 446470006260 putative substrate binding site [chemical binding]; other site 446470006261 catalytic site [active] 446470006262 Predicted permeases [General function prediction only]; Region: RarD; COG2962 446470006263 Predicted transcriptional regulator [Transcription]; Region: COG2345 446470006264 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470006265 putative DNA binding site [nucleotide binding]; other site 446470006266 putative Zn2+ binding site [ion binding]; other site 446470006267 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 446470006268 FeS assembly protein SufB; Region: sufB; TIGR01980 446470006269 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 446470006270 FeS assembly protein SufD; Region: sufD; TIGR01981 446470006271 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 446470006272 [2Fe-2S] cluster binding site [ion binding]; other site 446470006273 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 446470006274 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 446470006275 Walker A/P-loop; other site 446470006276 ATP binding site [chemical binding]; other site 446470006277 Q-loop/lid; other site 446470006278 ABC transporter signature motif; other site 446470006279 Walker B; other site 446470006280 D-loop; other site 446470006281 H-loop/switch region; other site 446470006282 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446470006283 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446470006284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470006285 catalytic residue [active] 446470006286 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 446470006287 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446470006288 trimerization site [polypeptide binding]; other site 446470006289 active site 446470006290 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446470006291 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 446470006292 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446470006293 putative active site [active] 446470006294 catalytic site [active] 446470006295 putative metal binding site [ion binding]; other site 446470006296 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 446470006297 Cupin domain; Region: Cupin_2; cl17218 446470006298 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 446470006299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470006300 MarR family; Region: MarR_2; pfam12802 446470006301 Uncharacterized conserved protein [Function unknown]; Region: COG2353 446470006302 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470006303 nudix motif; other site 446470006304 flavodoxin; Provisional; Region: PRK06242 446470006305 CAAX protease self-immunity; Region: Abi; pfam02517 446470006306 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470006307 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470006308 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446470006309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470006310 Walker A/P-loop; other site 446470006311 ATP binding site [chemical binding]; other site 446470006312 Q-loop/lid; other site 446470006313 ABC transporter signature motif; other site 446470006314 Walker B; other site 446470006315 D-loop; other site 446470006316 H-loop/switch region; other site 446470006317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446470006318 Histidine kinase; Region: HisKA_3; pfam07730 446470006319 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470006320 Mg2+ binding site [ion binding]; other site 446470006321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470006323 active site 446470006324 phosphorylation site [posttranslational modification] 446470006325 intermolecular recognition site; other site 446470006326 dimerization interface [polypeptide binding]; other site 446470006327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470006328 DNA binding residues [nucleotide binding] 446470006329 dimerization interface [polypeptide binding]; other site 446470006330 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470006331 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470006332 conserved cys residue [active] 446470006333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470006334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470006335 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470006336 putative NAD(P) binding site [chemical binding]; other site 446470006337 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446470006338 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446470006339 ATP binding site [chemical binding]; other site 446470006340 Mg++ binding site [ion binding]; other site 446470006341 motif III; other site 446470006342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470006343 nucleotide binding region [chemical binding]; other site 446470006344 ATP-binding site [chemical binding]; other site 446470006345 VanZ like family; Region: VanZ; pfam04892 446470006346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006348 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 446470006349 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 446470006350 active site 446470006351 catalytic triad [active] 446470006352 dimer interface [polypeptide binding]; other site 446470006353 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 446470006354 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 446470006355 active site 446470006356 Zn binding site [ion binding]; other site 446470006357 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 446470006358 Predicted permeases [General function prediction only]; Region: COG0679 446470006359 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446470006360 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446470006361 Phosphotransferase enzyme family; Region: APH; pfam01636 446470006362 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470006363 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 446470006364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470006365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470006366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470006367 Coenzyme A binding pocket [chemical binding]; other site 446470006368 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 446470006369 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 446470006370 Bacterial PH domain; Region: DUF304; pfam03703 446470006371 Bacterial PH domain; Region: DUF304; cl01348 446470006372 Bacterial PH domain; Region: DUF304; pfam03703 446470006373 Bacterial PH domain; Region: DUF304; cl01348 446470006374 MoxR-like ATPases [General function prediction only]; Region: COG0714 446470006375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470006376 Walker A motif; other site 446470006377 ATP binding site [chemical binding]; other site 446470006378 Walker B motif; other site 446470006379 arginine finger; other site 446470006380 Protein of unknown function DUF58; Region: DUF58; pfam01882 446470006381 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 446470006382 hypothetical protein; Provisional; Region: PRK13685 446470006383 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446470006384 metal ion-dependent adhesion site (MIDAS); other site 446470006385 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 446470006386 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446470006387 NAD(P) binding site [chemical binding]; other site 446470006388 homotetramer interface [polypeptide binding]; other site 446470006389 homodimer interface [polypeptide binding]; other site 446470006390 active site 446470006391 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 446470006392 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 446470006393 NAD binding site [chemical binding]; other site 446470006394 homotetramer interface [polypeptide binding]; other site 446470006395 homodimer interface [polypeptide binding]; other site 446470006396 substrate binding site [chemical binding]; other site 446470006397 active site 446470006398 ferrochelatase; Reviewed; Region: hemH; PRK00035 446470006399 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446470006400 C-terminal domain interface [polypeptide binding]; other site 446470006401 active site 446470006402 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446470006403 active site 446470006404 N-terminal domain interface [polypeptide binding]; other site 446470006405 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 446470006406 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446470006407 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446470006408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470006409 dimerization interface [polypeptide binding]; other site 446470006410 putative DNA binding site [nucleotide binding]; other site 446470006411 putative Zn2+ binding site [ion binding]; other site 446470006412 TIGR03089 family protein; Region: TIGR03089 446470006413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006415 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 446470006416 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446470006417 active site 446470006418 ribulose/triose binding site [chemical binding]; other site 446470006419 phosphate binding site [ion binding]; other site 446470006420 substrate (anthranilate) binding pocket [chemical binding]; other site 446470006421 product (indole) binding pocket [chemical binding]; other site 446470006422 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 446470006423 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446470006424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470006425 catalytic residue [active] 446470006426 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 446470006427 substrate binding site [chemical binding]; other site 446470006428 active site 446470006429 catalytic residues [active] 446470006430 heterodimer interface [polypeptide binding]; other site 446470006431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470006432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470006433 homodimer interface [polypeptide binding]; other site 446470006434 catalytic residue [active] 446470006435 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 446470006436 hypothetical protein; Provisional; Region: PRK06753 446470006437 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470006438 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446470006439 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 446470006440 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 446470006441 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 446470006442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470006444 putative substrate translocation pore; other site 446470006445 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446470006446 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446470006447 dimer interface [polypeptide binding]; other site 446470006448 anticodon binding site; other site 446470006449 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 446470006450 homodimer interface [polypeptide binding]; other site 446470006451 motif 1; other site 446470006452 active site 446470006453 motif 2; other site 446470006454 GAD domain; Region: GAD; pfam02938 446470006455 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470006456 active site 446470006457 motif 3; other site 446470006458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470006459 MarR family; Region: MarR_2; pfam12802 446470006460 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446470006461 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446470006462 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 446470006463 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470006464 hypothetical protein; Provisional; Region: PRK06753 446470006465 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470006466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446470006467 NACHT domain; Region: NACHT; pfam05729 446470006468 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 446470006469 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 446470006470 active site 446470006471 putative substrate binding pocket [chemical binding]; other site 446470006472 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470006473 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446470006474 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446470006475 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470006476 MarR family; Region: MarR_2; pfam12802 446470006477 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 446470006478 metal-binding site 446470006479 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446470006480 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 446470006481 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446470006482 putative OHCU decarboxylase; Provisional; Region: PRK13798 446470006483 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 446470006484 active site 446470006485 homotetramer interface [polypeptide binding]; other site 446470006486 urate oxidase; Region: urate_oxi; TIGR03383 446470006487 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446470006488 active site 446470006489 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 446470006490 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 446470006491 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 446470006492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446470006493 catalytic loop [active] 446470006494 iron binding site [ion binding]; other site 446470006495 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446470006496 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 446470006497 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 446470006498 active site 446470006499 putative substrate binding pocket [chemical binding]; other site 446470006500 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 446470006501 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 446470006502 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446470006503 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 446470006504 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 446470006505 XdhC Rossmann domain; Region: XdhC_C; pfam13478 446470006506 allophanate hydrolase; Provisional; Region: PRK08186 446470006507 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 446470006508 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 446470006509 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446470006510 glyoxylate carboligase; Provisional; Region: PRK11269 446470006511 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446470006512 PYR/PP interface [polypeptide binding]; other site 446470006513 dimer interface [polypeptide binding]; other site 446470006514 TPP binding site [chemical binding]; other site 446470006515 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446470006516 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446470006517 TPP-binding site [chemical binding]; other site 446470006518 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446470006519 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 446470006520 allantoinase; Region: allantoinase; TIGR03178 446470006521 active site 446470006522 allantoicase; Provisional; Region: PRK13257 446470006523 Allantoicase repeat; Region: Allantoicase; pfam03561 446470006524 Allantoicase repeat; Region: Allantoicase; pfam03561 446470006525 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 446470006526 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446470006527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470006528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470006529 Histidine kinase; Region: HisKA_3; pfam07730 446470006530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470006531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470006532 active site 446470006533 phosphorylation site [posttranslational modification] 446470006534 intermolecular recognition site; other site 446470006535 dimerization interface [polypeptide binding]; other site 446470006536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470006537 DNA binding residues [nucleotide binding] 446470006538 dimerization interface [polypeptide binding]; other site 446470006539 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 446470006540 catalytic residues [active] 446470006541 dimer interface [polypeptide binding]; other site 446470006542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470006543 Coenzyme A binding pocket [chemical binding]; other site 446470006544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470006547 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470006548 active site 446470006549 catalytic tetrad [active] 446470006550 primosome assembly protein PriA; Provisional; Region: PRK14873 446470006551 NACHT domain; Region: NACHT; pfam05729 446470006552 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 446470006553 L11 interface [polypeptide binding]; other site 446470006554 putative EF-Tu interaction site [polypeptide binding]; other site 446470006555 putative EF-G interaction site [polypeptide binding]; other site 446470006556 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470006557 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470006558 Helix-turn-helix domain; Region: HTH_38; pfam13936 446470006559 MarR family; Region: MarR_2; pfam12802 446470006560 potential frameshift: common BLAST hit: gi|251795676|ref|YP_003010407.1| beta-lactamase 446470006561 Predicted transcriptional regulators [Transcription]; Region: COG1725 446470006562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470006563 DNA-binding site [nucleotide binding]; DNA binding site 446470006564 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470006565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470006566 Walker A/P-loop; other site 446470006567 ATP binding site [chemical binding]; other site 446470006568 Q-loop/lid; other site 446470006569 ABC transporter signature motif; other site 446470006570 Walker B; other site 446470006571 D-loop; other site 446470006572 H-loop/switch region; other site 446470006573 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446470006574 active site 446470006575 catalytic residues [active] 446470006576 metal binding site [ion binding]; metal-binding site 446470006577 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446470006578 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446470006579 putative active site [active] 446470006580 substrate binding site [chemical binding]; other site 446470006581 putative cosubstrate binding site; other site 446470006582 catalytic site [active] 446470006583 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446470006584 substrate binding site [chemical binding]; other site 446470006585 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446470006586 putative RNA binding site [nucleotide binding]; other site 446470006587 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 446470006588 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 446470006589 SWIM zinc finger; Region: SWIM; pfam04434 446470006590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470006592 active site 446470006593 phosphorylation site [posttranslational modification] 446470006594 intermolecular recognition site; other site 446470006595 dimerization interface [polypeptide binding]; other site 446470006596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470006597 DNA binding residues [nucleotide binding] 446470006598 dimerization interface [polypeptide binding]; other site 446470006599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470006600 Histidine kinase; Region: HisKA_3; pfam07730 446470006601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470006602 ATP binding site [chemical binding]; other site 446470006603 Mg2+ binding site [ion binding]; other site 446470006604 G-X-G motif; other site 446470006605 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470006606 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 446470006607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470006608 motif II; other site 446470006609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470006610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470006611 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470006612 dimerization interface [polypeptide binding]; other site 446470006613 substrate binding pocket [chemical binding]; other site 446470006614 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446470006615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006616 putative substrate translocation pore; other site 446470006617 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446470006618 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470006619 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470006620 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470006621 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470006622 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470006623 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 446470006624 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446470006625 active site 446470006626 catalytic triad [active] 446470006627 dimer interface [polypeptide binding]; other site 446470006628 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 446470006629 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446470006630 active site 446470006631 catalytic triad [active] 446470006632 dimer interface [polypeptide binding]; other site 446470006633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006635 WHG domain; Region: WHG; pfam13305 446470006636 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 446470006637 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 446470006638 substrate binding site [chemical binding]; other site 446470006639 hexamer interface [polypeptide binding]; other site 446470006640 metal binding site [ion binding]; metal-binding site 446470006641 Response regulator receiver domain; Region: Response_reg; pfam00072 446470006642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470006643 active site 446470006644 phosphorylation site [posttranslational modification] 446470006645 intermolecular recognition site; other site 446470006646 dimerization interface [polypeptide binding]; other site 446470006647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470006648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470006649 metal binding site [ion binding]; metal-binding site 446470006650 active site 446470006651 I-site; other site 446470006652 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446470006653 classical (c) SDRs; Region: SDR_c; cd05233 446470006654 NAD(P) binding site [chemical binding]; other site 446470006655 active site 446470006656 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 446470006657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470006658 S-adenosylmethionine binding site [chemical binding]; other site 446470006659 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446470006660 Lumazine binding domain; Region: Lum_binding; pfam00677 446470006661 Lumazine binding domain; Region: Lum_binding; pfam00677 446470006662 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446470006663 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 446470006664 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446470006665 dimerization interface [polypeptide binding]; other site 446470006666 active site 446470006667 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446470006668 homopentamer interface [polypeptide binding]; other site 446470006669 active site 446470006670 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 446470006671 homodimer interface [polypeptide binding]; other site 446470006672 putative metal binding site [ion binding]; other site 446470006673 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446470006674 ATP phosphoribosyltransferase; Region: HisG; cl15266 446470006675 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 446470006676 Protein of unknown function, DUF606; Region: DUF606; pfam04657 446470006677 Protein of unknown function, DUF606; Region: DUF606; pfam04657 446470006678 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 446470006679 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470006680 DNA binding residues [nucleotide binding] 446470006681 dimer interface [polypeptide binding]; other site 446470006682 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446470006683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470006684 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446470006685 active site 446470006686 DoxX-like family; Region: DoxX_2; pfam13564 446470006687 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 446470006688 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 446470006689 dimer interface [polypeptide binding]; other site 446470006690 putative tRNA-binding site [nucleotide binding]; other site 446470006691 enterobactin exporter EntS; Provisional; Region: PRK10489 446470006692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006693 putative substrate translocation pore; other site 446470006694 DoxX-like family; Region: DoxX_2; pfam13564 446470006695 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446470006696 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470006697 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470006698 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470006699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470006700 Walker A/P-loop; other site 446470006701 ATP binding site [chemical binding]; other site 446470006702 Q-loop/lid; other site 446470006703 ABC transporter signature motif; other site 446470006704 Walker B; other site 446470006705 D-loop; other site 446470006706 H-loop/switch region; other site 446470006707 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446470006708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006710 NAD-dependent deacetylase; Provisional; Region: PRK00481 446470006711 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 446470006712 NAD+ binding site [chemical binding]; other site 446470006713 substrate binding site [chemical binding]; other site 446470006714 Zn binding site [ion binding]; other site 446470006715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470006716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006717 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470006718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470006719 Walker A/P-loop; other site 446470006720 ATP binding site [chemical binding]; other site 446470006721 Q-loop/lid; other site 446470006722 ABC transporter signature motif; other site 446470006723 Walker B; other site 446470006724 D-loop; other site 446470006725 H-loop/switch region; other site 446470006726 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470006727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470006728 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446470006729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470006730 putative PBP binding loops; other site 446470006731 ABC-ATPase subunit interface; other site 446470006732 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470006733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470006734 dimer interface [polypeptide binding]; other site 446470006735 conserved gate region; other site 446470006736 putative PBP binding loops; other site 446470006737 ABC-ATPase subunit interface; other site 446470006738 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470006739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470006740 Walker A/P-loop; other site 446470006741 ATP binding site [chemical binding]; other site 446470006742 Q-loop/lid; other site 446470006743 ABC transporter signature motif; other site 446470006744 Walker B; other site 446470006745 D-loop; other site 446470006746 H-loop/switch region; other site 446470006747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470006748 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446470006749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446470006750 substrate binding site [chemical binding]; other site 446470006751 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446470006752 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446470006753 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446470006754 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446470006755 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 446470006756 active site 446470006757 catalytic residues [active] 446470006758 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 446470006759 substrate binding pocket [chemical binding]; other site 446470006760 catalytic residues [active] 446470006761 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 446470006762 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 446470006763 predicted active site [active] 446470006764 catalytic triad [active] 446470006765 hypothetical protein; Validated; Region: PRK00110 446470006766 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 446470006767 EamA-like transporter family; Region: EamA; pfam00892 446470006768 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446470006769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470006770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470006771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470006772 hypothetical protein; Provisional; Region: PRK06185 446470006773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446470006774 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 446470006775 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470006776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470006777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470006778 binding surface 446470006779 TPR motif; other site 446470006780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470006781 TPR motif; other site 446470006782 binding surface 446470006783 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470006784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470006785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446470006786 TPR motif; other site 446470006787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470006788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470006789 Coenzyme A binding pocket [chemical binding]; other site 446470006790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006791 putative substrate translocation pore; other site 446470006792 RibD C-terminal domain; Region: RibD_C; cl17279 446470006793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470006794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470006795 active site 446470006796 phosphorylation site [posttranslational modification] 446470006797 intermolecular recognition site; other site 446470006798 dimerization interface [polypeptide binding]; other site 446470006799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470006800 DNA binding residues [nucleotide binding] 446470006801 dimerization interface [polypeptide binding]; other site 446470006802 Putative sensor; Region: Sensor; pfam13796 446470006803 Histidine kinase; Region: HisKA_3; pfam07730 446470006804 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470006805 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470006806 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470006807 Walker A/P-loop; other site 446470006808 ATP binding site [chemical binding]; other site 446470006809 Q-loop/lid; other site 446470006810 ABC transporter signature motif; other site 446470006811 Walker B; other site 446470006812 D-loop; other site 446470006813 H-loop/switch region; other site 446470006814 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470006815 FtsX-like permease family; Region: FtsX; pfam02687 446470006816 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446470006817 Uncharacterized conserved protein [Function unknown]; Region: COG3342 446470006818 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 446470006819 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 446470006820 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446470006821 catalytic residues [active] 446470006822 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 446470006823 TrkA-C domain; Region: TrkA_C; pfam02080 446470006824 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446470006825 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446470006826 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446470006827 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 446470006828 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446470006829 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 446470006830 Moco binding site; other site 446470006831 metal coordination site [ion binding]; other site 446470006832 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446470006833 active site 446470006834 catalytic triad [active] 446470006835 oxyanion hole [active] 446470006836 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446470006837 hypothetical protein; Provisional; Region: PRK07906 446470006838 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446470006839 putative metal binding site [ion binding]; other site 446470006840 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446470006841 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 446470006842 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 446470006843 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 446470006844 catalytic triad [active] 446470006845 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 446470006846 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470006847 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 446470006848 cell division protein MraZ; Reviewed; Region: PRK00326 446470006849 MraZ protein; Region: MraZ; pfam02381 446470006850 MraZ protein; Region: MraZ; pfam02381 446470006851 MraW methylase family; Region: Methyltransf_5; pfam01795 446470006852 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 446470006853 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446470006854 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446470006855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446470006856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470006858 putative substrate translocation pore; other site 446470006859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006860 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470006861 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470006862 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 446470006863 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 446470006864 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 446470006865 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 446470006866 RNA binding site [nucleotide binding]; other site 446470006867 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446470006868 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446470006869 active site 446470006870 DNA binding site [nucleotide binding] 446470006871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470006872 Histidine kinase; Region: HisKA_3; pfam07730 446470006873 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470006874 ATP binding site [chemical binding]; other site 446470006875 Mg2+ binding site [ion binding]; other site 446470006876 G-X-G motif; other site 446470006877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470006878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470006879 active site 446470006880 phosphorylation site [posttranslational modification] 446470006881 intermolecular recognition site; other site 446470006882 dimerization interface [polypeptide binding]; other site 446470006883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470006884 DNA binding residues [nucleotide binding] 446470006885 dimerization interface [polypeptide binding]; other site 446470006886 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470006887 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 446470006888 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470006889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470006890 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470006891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470006892 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446470006893 putative ADP-binding pocket [chemical binding]; other site 446470006894 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 446470006895 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470006896 Cytochrome P450; Region: p450; cl12078 446470006897 Methyltransferase domain; Region: Methyltransf_12; pfam08242 446470006898 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 446470006899 hypothetical protein; Provisional; Region: PRK06126 446470006900 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470006901 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446470006902 Transglycosylase; Region: Transgly; pfam00912 446470006903 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446470006904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470006905 S-adenosylmethionine binding site [chemical binding]; other site 446470006906 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470006907 nucleotide binding site [chemical binding]; other site 446470006908 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470006909 SBD interface [polypeptide binding]; other site 446470006910 OsmC-like protein; Region: OsmC; pfam02566 446470006911 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470006912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470006913 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470006914 catalytic site [active] 446470006915 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446470006916 hydrophobic ligand binding site; other site 446470006917 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 446470006918 putative substrate binding site [chemical binding]; other site 446470006919 active site 446470006920 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446470006921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470006922 DNA-binding site [nucleotide binding]; DNA binding site 446470006923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470006925 homodimer interface [polypeptide binding]; other site 446470006926 catalytic residue [active] 446470006927 Predicted membrane protein [Function unknown]; Region: COG2364 446470006928 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446470006929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470006930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470006931 RibD C-terminal domain; Region: RibD_C; cl17279 446470006932 CBD_II domain; Region: CBD_II; smart00637 446470006933 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446470006934 Interdomain contacts; other site 446470006935 Cytokine receptor motif; other site 446470006936 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 446470006937 active site 446470006938 uridine kinase; Validated; Region: PRK06696 446470006939 active site 446470006940 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446470006941 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470006942 putative catalytic site [active] 446470006943 putative metal binding site [ion binding]; other site 446470006944 putative phosphate binding site [ion binding]; other site 446470006945 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470006946 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 446470006947 active site 446470006948 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 446470006949 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446470006950 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470006951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470006952 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470006953 Cytochrome P450; Region: p450; cl12078 446470006954 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 446470006955 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 446470006956 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470006957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470006958 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470006959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470006960 DNA binding site [nucleotide binding] 446470006961 domain linker motif; other site 446470006962 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470006963 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 446470006964 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446470006965 active site 446470006966 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470006967 DNA binding site [nucleotide binding] 446470006968 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446470006969 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446470006970 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446470006971 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446470006972 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446470006973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446470006974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470006975 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446470006976 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 446470006977 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 446470006978 [4Fe-4S] binding site [ion binding]; other site 446470006979 molybdopterin cofactor binding site; other site 446470006980 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 446470006981 molybdopterin cofactor binding site; other site 446470006982 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 446470006983 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470006984 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446470006985 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470006986 AsnC family; Region: AsnC_trans_reg; pfam01037 446470006987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470006988 putative substrate translocation pore; other site 446470006989 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446470006990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470006991 DNA-binding site [nucleotide binding]; DNA binding site 446470006992 FCD domain; Region: FCD; pfam07729 446470006993 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470006994 classical (c) SDRs; Region: SDR_c; cd05233 446470006995 NAD(P) binding site [chemical binding]; other site 446470006996 active site 446470006997 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 446470006998 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 446470006999 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 446470007000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470007001 catalytic residue [active] 446470007002 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 446470007003 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 446470007004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470007005 catalytic residue [active] 446470007006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470007007 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470007008 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 446470007009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470007010 dimer interface [polypeptide binding]; other site 446470007011 conserved gate region; other site 446470007012 putative PBP binding loops; other site 446470007013 ABC-ATPase subunit interface; other site 446470007014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470007015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470007016 dimer interface [polypeptide binding]; other site 446470007017 conserved gate region; other site 446470007018 putative PBP binding loops; other site 446470007019 ABC-ATPase subunit interface; other site 446470007020 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446470007021 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446470007022 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446470007023 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446470007024 alpha-glucosidase; Provisional; Region: PRK10137 446470007025 Trehalase; Region: Trehalase; cl17346 446470007026 hypothetical protein; Provisional; Region: PRK07236 446470007027 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 446470007028 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446470007029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470007030 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446470007031 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 446470007032 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470007033 Cytochrome P450; Region: p450; cl12078 446470007034 Helix-turn-helix domain; Region: HTH_38; pfam13936 446470007035 MarR family; Region: MarR_2; pfam12802 446470007036 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 446470007037 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 446470007038 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446470007039 cobyric acid synthase; Provisional; Region: PRK00784 446470007040 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 446470007041 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 446470007042 catalytic triad [active] 446470007043 Pirin-related protein [General function prediction only]; Region: COG1741 446470007044 Pirin; Region: Pirin; pfam02678 446470007045 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446470007046 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470007047 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470007048 Walker A/P-loop; other site 446470007049 ATP binding site [chemical binding]; other site 446470007050 Q-loop/lid; other site 446470007051 ABC transporter signature motif; other site 446470007052 Walker B; other site 446470007053 D-loop; other site 446470007054 H-loop/switch region; other site 446470007055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446470007056 ABC-ATPase subunit interface; other site 446470007057 dimer interface [polypeptide binding]; other site 446470007058 putative PBP binding regions; other site 446470007059 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470007060 ABC-ATPase subunit interface; other site 446470007061 dimer interface [polypeptide binding]; other site 446470007062 putative PBP binding regions; other site 446470007063 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446470007064 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446470007065 intersubunit interface [polypeptide binding]; other site 446470007066 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470007067 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446470007068 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 446470007069 putative active site [active] 446470007070 catalytic triad [active] 446470007071 putative dimer interface [polypeptide binding]; other site 446470007072 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 446470007073 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446470007074 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446470007075 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446470007076 putative active site [active] 446470007077 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 446470007078 active site 446470007079 catalytic residues [active] 446470007080 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 446470007081 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446470007082 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446470007083 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446470007084 putative active site [active] 446470007085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470007086 Coenzyme A binding pocket [chemical binding]; other site 446470007087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470007088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470007089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470007090 putative PBP binding loops; other site 446470007091 dimer interface [polypeptide binding]; other site 446470007092 ABC-ATPase subunit interface; other site 446470007093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470007094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470007095 dimer interface [polypeptide binding]; other site 446470007096 conserved gate region; other site 446470007097 putative PBP binding loops; other site 446470007098 ABC-ATPase subunit interface; other site 446470007099 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446470007100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007101 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470007102 NAD(P) binding site [chemical binding]; other site 446470007103 active site 446470007104 EamA-like transporter family; Region: EamA; pfam00892 446470007105 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446470007106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470007107 MarR family; Region: MarR; pfam01047 446470007108 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446470007109 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446470007110 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470007111 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470007112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470007113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007114 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470007115 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 446470007116 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 446470007117 [2Fe-2S] cluster binding site [ion binding]; other site 446470007118 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 446470007119 alpha subunit interface [polypeptide binding]; other site 446470007120 active site 446470007121 substrate binding site [chemical binding]; other site 446470007122 Fe binding site [ion binding]; other site 446470007123 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 446470007124 AAA ATPase domain; Region: AAA_16; pfam13191 446470007125 NB-ARC domain; Region: NB-ARC; pfam00931 446470007126 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470007127 Ligand Binding Site [chemical binding]; other site 446470007128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470007129 Ligand Binding Site [chemical binding]; other site 446470007130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470007131 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 446470007132 putative NAD(P) binding site [chemical binding]; other site 446470007133 active site 446470007134 putative substrate binding site [chemical binding]; other site 446470007135 Hemerythrin-like domain; Region: Hr-like; cd12108 446470007136 Fe binding site [ion binding]; other site 446470007137 oxidoreductase; Provisional; Region: PRK12743 446470007138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007139 NAD(P) binding site [chemical binding]; other site 446470007140 active site 446470007141 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 446470007142 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446470007143 NAD binding site [chemical binding]; other site 446470007144 catalytic Zn binding site [ion binding]; other site 446470007145 structural Zn binding site [ion binding]; other site 446470007146 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446470007147 putative hydrophobic ligand binding site [chemical binding]; other site 446470007148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470007149 dimerization interface [polypeptide binding]; other site 446470007150 putative DNA binding site [nucleotide binding]; other site 446470007151 putative Zn2+ binding site [ion binding]; other site 446470007152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007153 S-adenosylmethionine binding site [chemical binding]; other site 446470007154 AAA ATPase domain; Region: AAA_16; pfam13191 446470007155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470007156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470007157 DNA binding residues [nucleotide binding] 446470007158 dimerization interface [polypeptide binding]; other site 446470007159 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470007160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470007161 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470007162 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470007163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470007164 putative substrate translocation pore; other site 446470007165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 446470007166 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446470007167 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470007168 active site 446470007169 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470007170 active site 446470007171 pyruvate dehydrogenase; Provisional; Region: PRK09124 446470007172 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446470007173 PYR/PP interface [polypeptide binding]; other site 446470007174 dimer interface [polypeptide binding]; other site 446470007175 tetramer interface [polypeptide binding]; other site 446470007176 TPP binding site [chemical binding]; other site 446470007177 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446470007178 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 446470007179 TPP-binding site [chemical binding]; other site 446470007180 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 446470007181 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 446470007182 active site 446470007183 FMN binding site [chemical binding]; other site 446470007184 substrate binding site [chemical binding]; other site 446470007185 3Fe-4S cluster binding site [ion binding]; other site 446470007186 Hemerythrin-like domain; Region: Hr-like; cd12108 446470007187 thiamine pyrophosphate protein; Provisional; Region: PRK08273 446470007188 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446470007189 PYR/PP interface [polypeptide binding]; other site 446470007190 dimer interface [polypeptide binding]; other site 446470007191 tetramer interface [polypeptide binding]; other site 446470007192 TPP binding site [chemical binding]; other site 446470007193 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446470007194 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 446470007195 TPP-binding site [chemical binding]; other site 446470007196 FOG: CBS domain [General function prediction only]; Region: COG0517 446470007197 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 446470007198 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446470007199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470007200 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446470007201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470007202 DNA binding residues [nucleotide binding] 446470007203 ANTAR domain; Region: ANTAR; pfam03861 446470007204 PAS fold; Region: PAS_3; pfam08447 446470007205 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446470007206 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 446470007207 putative hydrophobic ligand binding site [chemical binding]; other site 446470007208 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 446470007209 nucleotide binding site [chemical binding]; other site 446470007210 Phosphotransferase enzyme family; Region: APH; pfam01636 446470007211 active site 446470007212 ATP binding site [chemical binding]; other site 446470007213 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470007214 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470007215 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470007216 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470007217 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 446470007218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470007219 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470007220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470007221 putative DNA binding site [nucleotide binding]; other site 446470007222 putative Zn2+ binding site [ion binding]; other site 446470007223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470007224 putative DNA binding site [nucleotide binding]; other site 446470007225 dimerization interface [polypeptide binding]; other site 446470007226 putative Zn2+ binding site [ion binding]; other site 446470007227 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446470007228 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446470007229 active site 446470007230 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446470007231 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446470007232 active site 446470007233 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 446470007234 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 446470007235 putative DNA binding site [nucleotide binding]; other site 446470007236 putative homodimer interface [polypeptide binding]; other site 446470007237 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 446470007238 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 446470007239 active site 446470007240 DNA binding site [nucleotide binding] 446470007241 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 446470007242 DNA binding site [nucleotide binding] 446470007243 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 446470007244 nucleotide binding site [chemical binding]; other site 446470007245 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470007246 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470007247 Walker A/P-loop; other site 446470007248 ATP binding site [chemical binding]; other site 446470007249 Q-loop/lid; other site 446470007250 ABC transporter signature motif; other site 446470007251 Walker B; other site 446470007252 D-loop; other site 446470007253 H-loop/switch region; other site 446470007254 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446470007255 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470007256 ABC-ATPase subunit interface; other site 446470007257 dimer interface [polypeptide binding]; other site 446470007258 putative PBP binding regions; other site 446470007259 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470007260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470007261 ABC-ATPase subunit interface; other site 446470007262 dimer interface [polypeptide binding]; other site 446470007263 putative PBP binding regions; other site 446470007264 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446470007265 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446470007266 siderophore binding site; other site 446470007267 Uncharacterized conserved protein [Function unknown]; Region: COG3402 446470007268 Bacterial PH domain; Region: DUF304; pfam03703 446470007269 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 446470007270 active site 446470007271 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470007272 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470007273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470007274 Walker A/P-loop; other site 446470007275 ATP binding site [chemical binding]; other site 446470007276 Q-loop/lid; other site 446470007277 ABC transporter signature motif; other site 446470007278 Walker B; other site 446470007279 D-loop; other site 446470007280 H-loop/switch region; other site 446470007281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470007282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470007283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470007284 Walker A/P-loop; other site 446470007285 ATP binding site [chemical binding]; other site 446470007286 Q-loop/lid; other site 446470007287 ABC transporter signature motif; other site 446470007288 Walker B; other site 446470007289 D-loop; other site 446470007290 H-loop/switch region; other site 446470007291 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446470007292 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446470007293 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 446470007294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470007295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470007296 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 446470007297 GTP cyclohydrolase I; Provisional; Region: PLN03044 446470007298 active site 446470007299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470007300 putative DNA binding site [nucleotide binding]; other site 446470007301 dimerization interface [polypeptide binding]; other site 446470007302 Predicted transcriptional regulator [Transcription]; Region: COG2345 446470007303 putative Zn2+ binding site [ion binding]; other site 446470007304 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 446470007305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470007306 Cytochrome P450; Region: p450; cl12078 446470007307 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446470007308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007309 tricarballylate dehydrogenase; Validated; Region: PRK08274 446470007310 Predicted oxidoreductase [General function prediction only]; Region: COG3573 446470007311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470007312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470007313 Coenzyme A binding pocket [chemical binding]; other site 446470007314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470007315 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446470007316 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 446470007317 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470007318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470007319 DNA binding residues [nucleotide binding] 446470007320 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470007321 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 446470007322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470007323 acyl-activating enzyme (AAE) consensus motif; other site 446470007324 AMP binding site [chemical binding]; other site 446470007325 active site 446470007326 CoA binding site [chemical binding]; other site 446470007327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470007328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470007329 non-specific DNA binding site [nucleotide binding]; other site 446470007330 salt bridge; other site 446470007331 sequence-specific DNA binding site [nucleotide binding]; other site 446470007332 Nitrate and nitrite sensing; Region: NIT; pfam08376 446470007333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470007334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470007335 ATP binding site [chemical binding]; other site 446470007336 Mg2+ binding site [ion binding]; other site 446470007337 G-X-G motif; other site 446470007338 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446470007339 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446470007340 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470007341 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446470007342 TM-ABC transporter signature motif; other site 446470007343 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446470007344 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446470007345 TM-ABC transporter signature motif; other site 446470007346 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446470007347 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446470007348 Walker A/P-loop; other site 446470007349 ATP binding site [chemical binding]; other site 446470007350 Q-loop/lid; other site 446470007351 ABC transporter signature motif; other site 446470007352 Walker B; other site 446470007353 D-loop; other site 446470007354 H-loop/switch region; other site 446470007355 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446470007356 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446470007357 Walker A/P-loop; other site 446470007358 ATP binding site [chemical binding]; other site 446470007359 Q-loop/lid; other site 446470007360 ABC transporter signature motif; other site 446470007361 Walker B; other site 446470007362 D-loop; other site 446470007363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007364 S-adenosylmethionine binding site [chemical binding]; other site 446470007365 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 446470007366 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446470007367 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446470007368 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446470007369 putative active site [active] 446470007370 hypothetical protein; Provisional; Region: PRK02947 446470007371 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446470007372 putative active site [active] 446470007373 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 446470007374 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470007375 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446470007376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446470007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470007378 putative PBP binding loops; other site 446470007379 dimer interface [polypeptide binding]; other site 446470007380 ABC-ATPase subunit interface; other site 446470007381 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470007382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470007383 dimer interface [polypeptide binding]; other site 446470007384 conserved gate region; other site 446470007385 ABC-ATPase subunit interface; other site 446470007386 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 446470007387 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470007388 Phosphotransferase enzyme family; Region: APH; pfam01636 446470007389 active site 446470007390 substrate binding site [chemical binding]; other site 446470007391 ATP binding site [chemical binding]; other site 446470007392 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 446470007393 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 446470007394 active site 446470007395 catalytic site [active] 446470007396 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 446470007397 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 446470007398 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470007399 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 446470007400 trimer interface [polypeptide binding]; other site 446470007401 active site 446470007402 substrate binding site [chemical binding]; other site 446470007403 CoA binding site [chemical binding]; other site 446470007404 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 446470007405 bile acid transporter; Region: bass; TIGR00841 446470007406 Sodium Bile acid symporter family; Region: SBF; cl17470 446470007407 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470007408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007409 S-adenosylmethionine binding site [chemical binding]; other site 446470007410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446470007411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470007413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470007414 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470007415 putative dimerization interface [polypeptide binding]; other site 446470007416 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470007417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007418 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470007419 NAD(P) binding site [chemical binding]; other site 446470007420 active site 446470007421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470007422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470007423 DNA binding site [nucleotide binding] 446470007424 domain linker motif; other site 446470007425 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470007426 dimerization interface [polypeptide binding]; other site 446470007427 ligand binding site [chemical binding]; other site 446470007428 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446470007429 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 446470007430 Cupin domain; Region: Cupin_2; pfam07883 446470007431 SnoaL-like domain; Region: SnoaL_4; pfam13577 446470007432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470007433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470007434 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470007435 dimerization interface [polypeptide binding]; other site 446470007436 substrate binding pocket [chemical binding]; other site 446470007437 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446470007438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007439 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446470007440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007442 short chain dehydrogenase; Provisional; Region: PRK12747 446470007443 NAD(P) binding site [chemical binding]; other site 446470007444 active site 446470007445 AAA domain; Region: AAA_17; cl17253 446470007446 AAA domain; Region: AAA_18; pfam13238 446470007447 ribulokinase; Provisional; Region: PRK04123 446470007448 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 446470007449 N- and C-terminal domain interface [polypeptide binding]; other site 446470007450 active site 446470007451 MgATP binding site [chemical binding]; other site 446470007452 catalytic site [active] 446470007453 metal binding site [ion binding]; metal-binding site 446470007454 carbohydrate binding site [chemical binding]; other site 446470007455 homodimer interface [polypeptide binding]; other site 446470007456 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 446470007457 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 446470007458 intersubunit interface [polypeptide binding]; other site 446470007459 active site 446470007460 Zn2+ binding site [ion binding]; other site 446470007461 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 446470007462 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446470007463 trimer interface [polypeptide binding]; other site 446470007464 substrate binding site [chemical binding]; other site 446470007465 Mn binding site [ion binding]; other site 446470007466 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446470007467 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446470007468 putative ligand binding site [chemical binding]; other site 446470007469 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446470007470 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446470007471 Walker A/P-loop; other site 446470007472 ATP binding site [chemical binding]; other site 446470007473 Q-loop/lid; other site 446470007474 ABC transporter signature motif; other site 446470007475 Walker B; other site 446470007476 D-loop; other site 446470007477 H-loop/switch region; other site 446470007478 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446470007479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470007480 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470007481 TM-ABC transporter signature motif; other site 446470007482 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470007483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470007484 DNA binding site [nucleotide binding] 446470007485 domain linker motif; other site 446470007486 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446470007487 ligand binding site [chemical binding]; other site 446470007488 dimerization interface (open form) [polypeptide binding]; other site 446470007489 dimerization interface (closed form) [polypeptide binding]; other site 446470007490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470007491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470007492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470007493 Coenzyme A binding pocket [chemical binding]; other site 446470007494 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470007495 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 446470007496 homotrimer interaction site [polypeptide binding]; other site 446470007497 putative active site [active] 446470007498 Rrf2 family protein; Region: rrf2_super; TIGR00738 446470007499 Transcriptional regulator; Region: Rrf2; pfam02082 446470007500 Transcriptional regulator; Region: Rrf2; cl17282 446470007501 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470007502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470007503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470007504 active site 446470007505 phosphorylation site [posttranslational modification] 446470007506 intermolecular recognition site; other site 446470007507 dimerization interface [polypeptide binding]; other site 446470007508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470007509 DNA binding site [nucleotide binding] 446470007510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470007511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470007512 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470007513 dimerization interface [polypeptide binding]; other site 446470007514 substrate binding pocket [chemical binding]; other site 446470007515 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 446470007516 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 446470007517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470007518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007519 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 446470007520 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 446470007521 acyl-activating enzyme (AAE) consensus motif; other site 446470007522 putative AMP binding site [chemical binding]; other site 446470007523 putative active site [active] 446470007524 putative CoA binding site [chemical binding]; other site 446470007525 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 446470007526 putative active site [active] 446470007527 putative catalytic site [active] 446470007528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470007529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470007530 active site 446470007531 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 446470007532 putative active site [active] 446470007533 putative substrate binding site [chemical binding]; other site 446470007534 ATP binding site [chemical binding]; other site 446470007535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470007536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470007537 active site 446470007538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470007539 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446470007540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470007541 active site 446470007542 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 446470007543 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470007544 NAD(P) binding site [chemical binding]; other site 446470007545 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446470007546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007547 NAD(P) binding site [chemical binding]; other site 446470007548 active site 446470007549 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446470007550 classical (c) SDRs; Region: SDR_c; cd05233 446470007551 NAD(P) binding site [chemical binding]; other site 446470007552 active site 446470007553 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446470007554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007555 NAD(P) binding site [chemical binding]; other site 446470007556 active site 446470007557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470007558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470007559 putative substrate translocation pore; other site 446470007560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470007561 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470007562 active site 446470007563 metal binding site [ion binding]; metal-binding site 446470007564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470007565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007566 S-adenosylmethionine binding site [chemical binding]; other site 446470007567 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470007568 Methyltransferase domain; Region: Methyltransf_25; pfam13649 446470007569 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 446470007570 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 446470007571 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446470007572 Ligand binding site; other site 446470007573 Putative Catalytic site; other site 446470007574 DXD motif; other site 446470007575 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470007576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007577 NAD(P) binding site [chemical binding]; other site 446470007578 active site 446470007579 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446470007580 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470007581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470007582 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470007583 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470007584 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446470007585 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 446470007586 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446470007587 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446470007588 PQQ-like domain; Region: PQQ_2; pfam13360 446470007589 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470007590 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446470007591 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446470007592 FAD binding pocket [chemical binding]; other site 446470007593 FAD binding motif [chemical binding]; other site 446470007594 phosphate binding motif [ion binding]; other site 446470007595 NAD binding pocket [chemical binding]; other site 446470007596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470007597 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446470007598 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470007599 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470007600 structural tetrad; other site 446470007601 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 446470007602 Tetratrico peptide repeat; Region: TPR_5; pfam12688 446470007603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470007604 putative DNA binding site [nucleotide binding]; other site 446470007605 putative Zn2+ binding site [ion binding]; other site 446470007606 Caspase domain; Region: Peptidase_C14; pfam00656 446470007607 AAA domain; Region: AAA_11; pfam13086 446470007608 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446470007609 Helicase; Region: Helicase_RecD; pfam05127 446470007610 AAA domain; Region: AAA_12; pfam13087 446470007611 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 446470007612 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 446470007613 Part of AAA domain; Region: AAA_19; pfam13245 446470007614 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446470007615 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446470007616 AAA domain; Region: AAA_12; pfam13087 446470007617 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 446470007618 putative active site [active] 446470007619 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446470007620 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446470007621 active site 446470007622 catalytic site [active] 446470007623 substrate binding site [chemical binding]; other site 446470007624 Tellurite resistance protein TerB; Region: TerB; cl17311 446470007625 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446470007626 Dimer interface [polypeptide binding]; other site 446470007627 BRCT sequence motif; other site 446470007628 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 446470007629 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446470007630 active site 446470007631 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446470007632 generic binding surface II; other site 446470007633 generic binding surface I; other site 446470007634 DNA Polymerase Y-family; Region: PolY_like; cd03468 446470007635 active site 446470007636 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 446470007637 DNA binding site [nucleotide binding] 446470007638 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446470007639 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446470007640 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 446470007641 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470007642 putative NAD(P) binding site [chemical binding]; other site 446470007643 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 446470007644 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446470007645 helix-hairpin-helix signature motif; other site 446470007646 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 446470007647 active site 446470007648 catalytic residues [active] 446470007649 enterobactin exporter EntS; Provisional; Region: PRK10489 446470007650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470007651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470007652 non-specific DNA binding site [nucleotide binding]; other site 446470007653 salt bridge; other site 446470007654 sequence-specific DNA binding site [nucleotide binding]; other site 446470007655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470007656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470007657 binding surface 446470007658 TPR motif; other site 446470007659 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470007660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470007661 binding surface 446470007662 TPR motif; other site 446470007663 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470007664 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 446470007665 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470007666 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470007667 NB-ARC domain; Region: NB-ARC; pfam00931 446470007668 AAA domain; Region: AAA_14; pfam13173 446470007669 TPR repeat; Region: TPR_11; pfam13414 446470007670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470007671 binding surface 446470007672 TPR motif; other site 446470007673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470007674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470007675 binding surface 446470007676 TPR motif; other site 446470007677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470007678 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470007679 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446470007680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470007681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470007682 Predicted membrane protein [Function unknown]; Region: COG2246 446470007683 GtrA-like protein; Region: GtrA; pfam04138 446470007684 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446470007685 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446470007686 Ligand binding site; other site 446470007687 Putative Catalytic site; other site 446470007688 DXD motif; other site 446470007689 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 446470007690 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446470007691 DXD motif; other site 446470007692 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446470007693 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446470007694 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 446470007695 FOG: PKD repeat [General function prediction only]; Region: COG3291 446470007696 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446470007697 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 446470007698 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 446470007699 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470007700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007701 S-adenosylmethionine binding site [chemical binding]; other site 446470007702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007703 S-adenosylmethionine binding site [chemical binding]; other site 446470007704 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470007705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007706 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446470007707 NAD(P) binding site [chemical binding]; other site 446470007708 active site 446470007709 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 446470007710 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 446470007711 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 446470007712 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446470007713 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 446470007714 putative active site [active] 446470007715 catalytic site [active] 446470007716 putative metal binding site [ion binding]; other site 446470007717 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470007718 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 446470007719 nucleotide binding site [chemical binding]; other site 446470007720 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470007721 SBD interface [polypeptide binding]; other site 446470007722 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446470007723 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446470007724 GIY-YIG motif/motif A; other site 446470007725 active site 446470007726 catalytic site [active] 446470007727 putative DNA binding site [nucleotide binding]; other site 446470007728 metal binding site [ion binding]; metal-binding site 446470007729 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446470007730 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 446470007731 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446470007732 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 446470007733 putative substrate binding pocket [chemical binding]; other site 446470007734 dimer interface [polypeptide binding]; other site 446470007735 phosphate binding site [ion binding]; other site 446470007736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446470007737 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446470007738 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 446470007739 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 446470007740 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446470007741 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446470007742 Phosphoglycerate kinase; Region: PGK; pfam00162 446470007743 substrate binding site [chemical binding]; other site 446470007744 hinge regions; other site 446470007745 ADP binding site [chemical binding]; other site 446470007746 catalytic site [active] 446470007747 triosephosphate isomerase; Provisional; Region: PRK14567 446470007748 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446470007749 substrate binding site [chemical binding]; other site 446470007750 dimer interface [polypeptide binding]; other site 446470007751 catalytic triad [active] 446470007752 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446470007753 peptide binding site [polypeptide binding]; other site 446470007754 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446470007755 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446470007756 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 446470007757 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446470007758 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 446470007759 Moco binding site; other site 446470007760 metal coordination site [ion binding]; other site 446470007761 acyl-CoA synthetase; Validated; Region: PRK07788 446470007762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470007763 acyl-activating enzyme (AAE) consensus motif; other site 446470007764 AMP binding site [chemical binding]; other site 446470007765 active site 446470007766 CoA binding site [chemical binding]; other site 446470007767 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446470007768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470007769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470007770 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446470007771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446470007772 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446470007773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446470007774 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470007775 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446470007776 DNA binding residues [nucleotide binding] 446470007777 drug binding residues [chemical binding]; other site 446470007778 dimer interface [polypeptide binding]; other site 446470007779 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 446470007780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470007781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470007782 Shikimate kinase; Region: SKI; pfam01202 446470007783 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446470007784 ADP binding site [chemical binding]; other site 446470007785 magnesium binding site [ion binding]; other site 446470007786 putative shikimate binding site; other site 446470007787 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 446470007788 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446470007789 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446470007790 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446470007791 active site 446470007792 catalytic residues [active] 446470007793 polyphosphate kinase; Provisional; Region: PRK05443 446470007794 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 446470007795 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 446470007796 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 446470007797 putative domain interface [polypeptide binding]; other site 446470007798 putative active site [active] 446470007799 catalytic site [active] 446470007800 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 446470007801 putative domain interface [polypeptide binding]; other site 446470007802 putative active site [active] 446470007803 catalytic site [active] 446470007804 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446470007805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470007806 DNA-binding site [nucleotide binding]; DNA binding site 446470007807 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446470007808 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446470007809 intersubunit interface [polypeptide binding]; other site 446470007810 active site 446470007811 catalytic residue [active] 446470007812 Predicted membrane protein [Function unknown]; Region: COG2259 446470007813 hypothetical protein; Validated; Region: PRK05868 446470007814 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470007815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470007816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007817 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470007818 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446470007819 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 446470007820 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 446470007821 active site 446470007822 catalytic residues [active] 446470007823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470007824 S-adenosylmethionine binding site [chemical binding]; other site 446470007825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470007826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470007827 active site 446470007828 SCP-2 sterol transfer family; Region: SCP2; pfam02036 446470007829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470007830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007831 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446470007832 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446470007833 active site 2 [active] 446470007834 active site 1 [active] 446470007835 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 446470007836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007837 NAD(P) binding site [chemical binding]; other site 446470007838 active site 446470007839 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 446470007840 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446470007841 dimer interface [polypeptide binding]; other site 446470007842 active site 446470007843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470007844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470007845 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446470007846 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 446470007847 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446470007848 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470007849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470007850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470007851 DNA binding residues [nucleotide binding] 446470007852 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470007853 HTH domain; Region: HTH_11; pfam08279 446470007854 WYL domain; Region: WYL; pfam13280 446470007855 short chain dehydrogenase; Provisional; Region: PRK08303 446470007856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007857 NAD(P) binding site [chemical binding]; other site 446470007858 active site 446470007859 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446470007860 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446470007861 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 446470007862 DXD motif; other site 446470007863 aconitate hydratase; Validated; Region: PRK09277 446470007864 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 446470007865 substrate binding site [chemical binding]; other site 446470007866 ligand binding site [chemical binding]; other site 446470007867 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446470007868 substrate binding site [chemical binding]; other site 446470007869 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 446470007870 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470007871 dimer interface [polypeptide binding]; other site 446470007872 putative metal binding site [ion binding]; other site 446470007873 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446470007874 short chain dehydrogenase; Provisional; Region: PRK06179 446470007875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470007876 NAD(P) binding site [chemical binding]; other site 446470007877 active site 446470007878 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 446470007879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470007880 Histidine kinase; Region: HisKA_3; pfam07730 446470007881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470007882 ATP binding site [chemical binding]; other site 446470007883 Mg2+ binding site [ion binding]; other site 446470007884 G-X-G motif; other site 446470007885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470007886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470007887 active site 446470007888 phosphorylation site [posttranslational modification] 446470007889 intermolecular recognition site; other site 446470007890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470007891 DNA binding residues [nucleotide binding] 446470007892 dimerization interface [polypeptide binding]; other site 446470007893 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 446470007894 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446470007895 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470007896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470007897 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470007898 DNA binding residues [nucleotide binding] 446470007899 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470007900 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470007901 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 446470007902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470007903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470007904 active site 446470007905 catalytic tetrad [active] 446470007906 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470007907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470007908 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470007909 DNA binding residues [nucleotide binding] 446470007910 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 446470007911 proline aminopeptidase P II; Provisional; Region: PRK10879 446470007912 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 446470007913 active site 446470007914 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 446470007915 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 446470007916 active site 446470007917 dimer interface [polypeptide binding]; other site 446470007918 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446470007919 Ligand Binding Site [chemical binding]; other site 446470007920 Molecular Tunnel; other site 446470007921 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 446470007922 active site 1 [active] 446470007923 active site 2 [active] 446470007924 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446470007925 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 446470007926 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446470007927 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446470007928 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 446470007929 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446470007930 23S rRNA binding site [nucleotide binding]; other site 446470007931 L21 binding site [polypeptide binding]; other site 446470007932 L13 binding site [polypeptide binding]; other site 446470007933 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446470007934 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 446470007935 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446470007936 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446470007937 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 446470007938 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446470007939 dimer interface [polypeptide binding]; other site 446470007940 motif 1; other site 446470007941 active site 446470007942 motif 2; other site 446470007943 motif 3; other site 446470007944 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446470007945 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446470007946 putative tRNA-binding site [nucleotide binding]; other site 446470007947 B3/4 domain; Region: B3_4; pfam03483 446470007948 tRNA synthetase B5 domain; Region: B5; smart00874 446470007949 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446470007950 dimer interface [polypeptide binding]; other site 446470007951 motif 1; other site 446470007952 motif 3; other site 446470007953 motif 2; other site 446470007954 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 446470007955 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 446470007956 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470007957 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470007958 NB-ARC domain; Region: NB-ARC; pfam00931 446470007959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470007960 TPR motif; other site 446470007961 binding surface 446470007962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470007963 TPR motif; other site 446470007964 binding surface 446470007965 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 446470007966 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446470007967 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446470007968 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 446470007969 heterotetramer interface [polypeptide binding]; other site 446470007970 active site pocket [active] 446470007971 cleavage site 446470007972 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 446470007973 feedback inhibition sensing region; other site 446470007974 homohexameric interface [polypeptide binding]; other site 446470007975 carbamate kinase; Reviewed; Region: PRK12686 446470007976 nucleotide binding site [chemical binding]; other site 446470007977 N-acetyl-L-glutamate binding site [chemical binding]; other site 446470007978 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446470007979 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470007980 inhibitor-cofactor binding pocket; inhibition site 446470007981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470007982 catalytic residue [active] 446470007983 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446470007984 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446470007985 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446470007986 arginine repressor; Provisional; Region: PRK03341 446470007987 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446470007988 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446470007989 argininosuccinate synthase; Provisional; Region: PRK13820 446470007990 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 446470007991 ANP binding site [chemical binding]; other site 446470007992 Substrate Binding Site II [chemical binding]; other site 446470007993 Substrate Binding Site I [chemical binding]; other site 446470007994 argininosuccinate lyase; Provisional; Region: PRK00855 446470007995 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446470007996 active sites [active] 446470007997 tetramer interface [polypeptide binding]; other site 446470007998 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470007999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470008000 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470008001 NAD(P) binding site [chemical binding]; other site 446470008002 active site 446470008003 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 446470008004 Amidohydrolase; Region: Amidohydro_4; pfam13147 446470008005 active site 446470008006 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446470008007 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 446470008008 putative active site [active] 446470008009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470008010 HIRAN domain; Region: HIRAN; pfam08797 446470008011 Protein of unknown function (DUF402); Region: DUF402; pfam04167 446470008012 Adenosylhomocysteinase; Provisional; Region: PTZ00075 446470008013 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 446470008014 homotetramer interface [polypeptide binding]; other site 446470008015 ligand binding site [chemical binding]; other site 446470008016 catalytic site [active] 446470008017 NAD binding site [chemical binding]; other site 446470008018 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 446470008019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470008020 TPR motif; other site 446470008021 binding surface 446470008022 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446470008023 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 446470008024 NAD binding site [chemical binding]; other site 446470008025 MarR family; Region: MarR_2; pfam12802 446470008026 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470008027 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470008028 EamA-like transporter family; Region: EamA; pfam00892 446470008029 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446470008030 EamA-like transporter family; Region: EamA; pfam00892 446470008031 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446470008032 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446470008033 tetramer interface [polypeptide binding]; other site 446470008034 active site 446470008035 Mg2+/Mn2+ binding site [ion binding]; other site 446470008036 Predicted ATPase [General function prediction only]; Region: COG3911 446470008037 AAA domain; Region: AAA_28; pfam13521 446470008038 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 446470008039 putative hydrophobic ligand binding site [chemical binding]; other site 446470008040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008041 AAA domain; Region: AAA_14; pfam13173 446470008042 NACHT domain; Region: NACHT; pfam05729 446470008043 Walker A/P-loop; other site 446470008044 ATP binding site [chemical binding]; other site 446470008045 Cytochrome P450; Region: p450; cl12078 446470008046 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 446470008047 dimer interface [polypeptide binding]; other site 446470008048 Citrate synthase; Region: Citrate_synt; pfam00285 446470008049 active site 446470008050 citrylCoA binding site [chemical binding]; other site 446470008051 oxalacetate/citrate binding site [chemical binding]; other site 446470008052 coenzyme A binding site [chemical binding]; other site 446470008053 catalytic triad [active] 446470008054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446470008055 active sites [active] 446470008056 tetramer interface [polypeptide binding]; other site 446470008057 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446470008058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446470008059 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446470008060 Histidine kinase; Region: HisKA_3; pfam07730 446470008061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470008062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470008063 ATP binding site [chemical binding]; other site 446470008064 Mg2+ binding site [ion binding]; other site 446470008065 G-X-G motif; other site 446470008066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470008068 active site 446470008069 phosphorylation site [posttranslational modification] 446470008070 intermolecular recognition site; other site 446470008071 dimerization interface [polypeptide binding]; other site 446470008072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008073 DNA binding residues [nucleotide binding] 446470008074 dimerization interface [polypeptide binding]; other site 446470008075 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 446470008076 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 446470008077 DNA binding site [nucleotide binding] 446470008078 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470008079 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470008080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446470008081 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 446470008082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 446470008083 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470008084 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470008085 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470008086 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 446470008087 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 446470008088 Cobalt transport protein; Region: CbiQ; cl00463 446470008089 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470008090 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446470008091 Walker A/P-loop; other site 446470008092 ATP binding site [chemical binding]; other site 446470008093 Q-loop/lid; other site 446470008094 ABC transporter signature motif; other site 446470008095 Walker B; other site 446470008096 D-loop; other site 446470008097 H-loop/switch region; other site 446470008098 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470008099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008100 Walker A/P-loop; other site 446470008101 ATP binding site [chemical binding]; other site 446470008102 Q-loop/lid; other site 446470008103 ABC transporter signature motif; other site 446470008104 Walker B; other site 446470008105 D-loop; other site 446470008106 H-loop/switch region; other site 446470008107 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 446470008108 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 446470008109 G1 box; other site 446470008110 putative GEF interaction site [polypeptide binding]; other site 446470008111 GTP/Mg2+ binding site [chemical binding]; other site 446470008112 Switch I region; other site 446470008113 G2 box; other site 446470008114 G3 box; other site 446470008115 Switch II region; other site 446470008116 G4 box; other site 446470008117 G5 box; other site 446470008118 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446470008119 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 446470008120 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 446470008121 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470008122 nucleotide binding site [chemical binding]; other site 446470008123 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470008124 SBD interface [polypeptide binding]; other site 446470008125 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470008126 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446470008127 structural tetrad; other site 446470008128 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446470008129 hypothetical protein; Provisional; Region: PRK06815 446470008130 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 446470008131 tetramer interface [polypeptide binding]; other site 446470008132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470008133 catalytic residue [active] 446470008134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470008135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470008136 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470008137 putative dimerization interface [polypeptide binding]; other site 446470008138 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470008139 PLD-like domain; Region: PLDc_2; pfam13091 446470008140 putative active site [active] 446470008141 catalytic site [active] 446470008142 PLD-like domain; Region: PLDc_2; pfam13091 446470008143 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470008144 putative active site [active] 446470008145 catalytic site [active] 446470008146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 446470008147 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470008148 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470008149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470008150 dimer interface [polypeptide binding]; other site 446470008151 conserved gate region; other site 446470008152 putative PBP binding loops; other site 446470008153 ABC-ATPase subunit interface; other site 446470008154 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470008155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470008156 dimer interface [polypeptide binding]; other site 446470008157 conserved gate region; other site 446470008158 putative PBP binding loops; other site 446470008159 ABC-ATPase subunit interface; other site 446470008160 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 446470008161 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 446470008162 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 446470008163 N- and C-terminal domain interface [polypeptide binding]; other site 446470008164 putative active site [active] 446470008165 MgATP binding site [chemical binding]; other site 446470008166 catalytic site [active] 446470008167 metal binding site [ion binding]; metal-binding site 446470008168 putative xylulose binding site [chemical binding]; other site 446470008169 putative homodimer interface [polypeptide binding]; other site 446470008170 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 446470008171 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 446470008172 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446470008173 substrate binding site [chemical binding]; other site 446470008174 trimer interface [polypeptide binding]; other site 446470008175 Mn binding site [ion binding]; other site 446470008176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470008177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470008178 DNA binding site [nucleotide binding] 446470008179 domain linker motif; other site 446470008180 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470008181 dimerization interface [polypeptide binding]; other site 446470008182 ligand binding site [chemical binding]; other site 446470008183 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446470008184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008185 Walker A/P-loop; other site 446470008186 ATP binding site [chemical binding]; other site 446470008187 Q-loop/lid; other site 446470008188 ABC transporter signature motif; other site 446470008189 Walker B; other site 446470008190 D-loop; other site 446470008191 H-loop/switch region; other site 446470008192 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446470008193 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470008194 TM-ABC transporter signature motif; other site 446470008195 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 446470008196 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 446470008197 ligand binding site [chemical binding]; other site 446470008198 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470008199 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470008200 DNA binding site [nucleotide binding] 446470008201 domain linker motif; other site 446470008202 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470008203 dimerization interface [polypeptide binding]; other site 446470008204 ligand binding site [chemical binding]; other site 446470008205 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470008206 MarR family; Region: MarR; pfam01047 446470008207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446470008208 Predicted GTPases [General function prediction only]; Region: COG1162 446470008209 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446470008210 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446470008211 GTP/Mg2+ binding site [chemical binding]; other site 446470008212 G4 box; other site 446470008213 G5 box; other site 446470008214 G1 box; other site 446470008215 Switch I region; other site 446470008216 G2 box; other site 446470008217 G3 box; other site 446470008218 Switch II region; other site 446470008219 hydrogenase 4 subunit F; Validated; Region: PRK06458 446470008220 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446470008221 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446470008222 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446470008223 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446470008224 Subtilisin inhibitor-like; Region: SSI; cl11594 446470008225 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 446470008226 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446470008227 Tetramer interface [polypeptide binding]; other site 446470008228 active site 446470008229 FMN-binding site [chemical binding]; other site 446470008230 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 446470008231 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446470008232 ADP binding site [chemical binding]; other site 446470008233 magnesium binding site [ion binding]; other site 446470008234 putative shikimate binding site; other site 446470008235 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446470008236 active site 446470008237 dimer interface [polypeptide binding]; other site 446470008238 metal binding site [ion binding]; metal-binding site 446470008239 Dehydroquinase class II; Region: DHquinase_II; pfam01220 446470008240 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446470008241 trimer interface [polypeptide binding]; other site 446470008242 active site 446470008243 dimer interface [polypeptide binding]; other site 446470008244 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446470008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008246 putative substrate translocation pore; other site 446470008247 elongation factor P; Validated; Region: PRK00529 446470008248 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446470008249 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 446470008250 RNA binding site [nucleotide binding]; other site 446470008251 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 446470008252 RNA binding site [nucleotide binding]; other site 446470008253 transcription antitermination factor NusB; Region: nusB; TIGR01951 446470008254 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470008255 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470008256 active site 446470008257 metal binding site [ion binding]; metal-binding site 446470008258 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470008259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470008260 non-specific DNA binding site [nucleotide binding]; other site 446470008261 salt bridge; other site 446470008262 sequence-specific DNA binding site [nucleotide binding]; other site 446470008263 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 446470008264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470008265 active site 446470008266 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446470008267 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446470008268 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446470008269 dihydroorotase; Validated; Region: pyrC; PRK09357 446470008270 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470008271 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446470008272 active site 446470008273 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446470008274 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 446470008275 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446470008276 catalytic site [active] 446470008277 subunit interface [polypeptide binding]; other site 446470008278 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446470008279 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446470008280 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446470008281 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 446470008282 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446470008283 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446470008284 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446470008285 IMP binding site; other site 446470008286 dimer interface [polypeptide binding]; other site 446470008287 interdomain contacts; other site 446470008288 partial ornithine binding site; other site 446470008289 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 446470008290 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 446470008291 quinone interaction residues [chemical binding]; other site 446470008292 active site 446470008293 catalytic residues [active] 446470008294 FMN binding site [chemical binding]; other site 446470008295 substrate binding site [chemical binding]; other site 446470008296 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 446470008297 active site 446470008298 dimer interface [polypeptide binding]; other site 446470008299 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 446470008300 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 446470008301 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 446470008302 catalytic site [active] 446470008303 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 446470008304 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446470008305 Flavoprotein; Region: Flavoprotein; pfam02441 446470008306 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 446470008307 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470008308 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446470008309 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446470008310 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446470008311 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446470008312 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 446470008313 active site 446470008314 putative catalytic site [active] 446470008315 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446470008316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470008317 motif II; other site 446470008318 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 446470008319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470008320 ATP binding site [chemical binding]; other site 446470008321 putative Mg++ binding site [ion binding]; other site 446470008322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470008323 nucleotide binding region [chemical binding]; other site 446470008324 ATP-binding site [chemical binding]; other site 446470008325 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446470008326 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 446470008327 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446470008328 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446470008329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470008330 MarR family; Region: MarR; pfam01047 446470008331 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 446470008332 Protein export membrane protein; Region: SecD_SecF; cl14618 446470008333 Phosphotransferase enzyme family; Region: APH; pfam01636 446470008334 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470008335 active site 446470008336 ATP binding site [chemical binding]; other site 446470008337 substrate binding site [chemical binding]; other site 446470008338 5'-3' exonuclease; Region: 53EXOc; smart00475 446470008339 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446470008340 active site 446470008341 metal binding site 1 [ion binding]; metal-binding site 446470008342 putative 5' ssDNA interaction site; other site 446470008343 metal binding site 3; metal-binding site 446470008344 metal binding site 2 [ion binding]; metal-binding site 446470008345 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446470008346 putative DNA binding site [nucleotide binding]; other site 446470008347 putative metal binding site [ion binding]; other site 446470008348 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470008349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470008350 active site 446470008351 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446470008352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470008353 putative DNA binding site [nucleotide binding]; other site 446470008354 putative Zn2+ binding site [ion binding]; other site 446470008355 AsnC family; Region: AsnC_trans_reg; pfam01037 446470008356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470008357 Amino acid permease; Region: AA_permease; pfam00324 446470008358 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446470008359 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470008360 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470008361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470008362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470008363 non-specific DNA binding site [nucleotide binding]; other site 446470008364 salt bridge; other site 446470008365 sequence-specific DNA binding site [nucleotide binding]; other site 446470008366 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446470008367 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 446470008368 putative active site [active] 446470008369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470008371 Coenzyme A binding pocket [chemical binding]; other site 446470008372 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446470008373 Uncharacterized conserved protein [Function unknown]; Region: COG1739 446470008374 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 446470008375 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470008376 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470008377 Inositol monophosphatase family; Region: Inositol_P; pfam00459 446470008378 active site 446470008379 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 446470008380 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470008381 active site 446470008382 DNA binding site [nucleotide binding] 446470008383 Int/Topo IB signature motif; other site 446470008384 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446470008385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008386 Coenzyme A binding pocket [chemical binding]; other site 446470008387 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 446470008388 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446470008389 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446470008390 DNA binding site [nucleotide binding] 446470008391 active site 446470008392 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446470008393 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446470008394 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446470008395 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 446470008396 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446470008397 minor groove reading motif; other site 446470008398 helix-hairpin-helix signature motif; other site 446470008399 substrate binding pocket [chemical binding]; other site 446470008400 active site 446470008401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470008402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008403 Coenzyme A binding pocket [chemical binding]; other site 446470008404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470008405 nudix motif; other site 446470008406 Uncharacterized conserved protein [Function unknown]; Region: COG3379 446470008407 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446470008408 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446470008409 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446470008410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470008411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470008412 dimer interface [polypeptide binding]; other site 446470008413 conserved gate region; other site 446470008414 putative PBP binding loops; other site 446470008415 ABC-ATPase subunit interface; other site 446470008416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470008417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470008418 dimer interface [polypeptide binding]; other site 446470008419 conserved gate region; other site 446470008420 putative PBP binding loops; other site 446470008421 ABC-ATPase subunit interface; other site 446470008422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470008423 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470008424 Walker A/P-loop; other site 446470008425 ATP binding site [chemical binding]; other site 446470008426 Q-loop/lid; other site 446470008427 ABC transporter signature motif; other site 446470008428 Walker B; other site 446470008429 D-loop; other site 446470008430 H-loop/switch region; other site 446470008431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470008432 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 446470008433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470008434 Walker A/P-loop; other site 446470008435 ATP binding site [chemical binding]; other site 446470008436 Q-loop/lid; other site 446470008437 ABC transporter signature motif; other site 446470008438 Walker B; other site 446470008439 D-loop; other site 446470008440 H-loop/switch region; other site 446470008441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470008442 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446470008443 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470008444 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470008445 conserved cys residue [active] 446470008446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470008447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008448 putative substrate translocation pore; other site 446470008449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470008450 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446470008451 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 446470008452 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 446470008453 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 446470008454 hypothetical protein; Provisional; Region: PRK04233 446470008455 SEC-C motif; Region: SEC-C; pfam02810 446470008456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470008457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470008458 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470008459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008460 Coenzyme A binding pocket [chemical binding]; other site 446470008461 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470008462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008463 Coenzyme A binding pocket [chemical binding]; other site 446470008464 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470008465 cleavage site 446470008466 active site 446470008467 substrate binding sites [chemical binding]; other site 446470008468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008469 Walker A/P-loop; other site 446470008470 ATP binding site [chemical binding]; other site 446470008471 Q-loop/lid; other site 446470008472 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446470008473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008474 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446470008475 Walker A/P-loop; other site 446470008476 ATP binding site [chemical binding]; other site 446470008477 Q-loop/lid; other site 446470008478 ABC transporter signature motif; other site 446470008479 Walker B; other site 446470008480 D-loop; other site 446470008481 H-loop/switch region; other site 446470008482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008483 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470008484 putative substrate translocation pore; other site 446470008485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470008486 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470008487 active site 446470008488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470008489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008490 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008491 DNA binding residues [nucleotide binding] 446470008492 dimerization interface [polypeptide binding]; other site 446470008493 Predicted ATPase [General function prediction only]; Region: COG3903 446470008494 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470008495 hypothetical protein; Provisional; Region: PRK06834 446470008496 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470008497 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470008498 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470008499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008500 Coenzyme A binding pocket [chemical binding]; other site 446470008501 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470008502 active site 446470008503 Int/Topo IB signature motif; other site 446470008504 DNA binding site [nucleotide binding] 446470008505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008507 WHG domain; Region: WHG; pfam13305 446470008508 short chain dehydrogenase; Provisional; Region: PRK06197 446470008509 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446470008510 putative NAD(P) binding site [chemical binding]; other site 446470008511 active site 446470008512 Phosphotransferase enzyme family; Region: APH; pfam01636 446470008513 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470008514 active site 446470008515 ATP binding site [chemical binding]; other site 446470008516 substrate binding site [chemical binding]; other site 446470008517 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 446470008518 putative active site [active] 446470008519 putative catalytic site [active] 446470008520 putative DNA binding site [nucleotide binding]; other site 446470008521 putative phosphate binding site [ion binding]; other site 446470008522 metal binding site A [ion binding]; metal-binding site 446470008523 putative AP binding site [nucleotide binding]; other site 446470008524 putative metal binding site B [ion binding]; other site 446470008525 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 446470008526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470008527 ATP binding site [chemical binding]; other site 446470008528 putative Mg++ binding site [ion binding]; other site 446470008529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470008530 nucleotide binding region [chemical binding]; other site 446470008531 ATP-binding site [chemical binding]; other site 446470008532 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 446470008533 EamA-like transporter family; Region: EamA; pfam00892 446470008534 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446470008535 EamA-like transporter family; Region: EamA; pfam00892 446470008536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008538 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470008539 putative phosphate binding site [ion binding]; other site 446470008540 PspC domain; Region: PspC; pfam04024 446470008541 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446470008542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470008543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470008544 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470008545 MarR family; Region: MarR; pfam01047 446470008546 MarR family; Region: MarR_2; cl17246 446470008547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008548 Coenzyme A binding pocket [chemical binding]; other site 446470008549 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446470008550 Acetokinase family; Region: Acetate_kinase; cl17229 446470008551 putative phosphoketolase; Provisional; Region: PRK05261 446470008552 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446470008553 TPP-binding site; other site 446470008554 XFP C-terminal domain; Region: XFP_C; pfam09363 446470008555 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470008556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470008557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470008558 DNA binding residues [nucleotide binding] 446470008559 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 446470008560 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 446470008561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470008562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470008563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446470008564 dimerization interface [polypeptide binding]; other site 446470008565 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446470008566 conserved cys residue [active] 446470008567 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446470008568 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446470008569 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446470008570 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446470008571 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470008572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470008573 dimer interface [polypeptide binding]; other site 446470008574 conserved gate region; other site 446470008575 putative PBP binding loops; other site 446470008576 ABC-ATPase subunit interface; other site 446470008577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470008578 dimer interface [polypeptide binding]; other site 446470008579 conserved gate region; other site 446470008580 putative PBP binding loops; other site 446470008581 ABC-ATPase subunit interface; other site 446470008582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470008583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470008584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470008585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470008586 DNA binding site [nucleotide binding] 446470008587 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470008588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470008589 nucleotide binding site [chemical binding]; other site 446470008590 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 446470008591 xylose isomerase; Provisional; Region: PRK12677 446470008592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470008593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470008594 Coenzyme A binding pocket [chemical binding]; other site 446470008595 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470008596 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 446470008597 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 446470008598 putative metal binding site [ion binding]; other site 446470008599 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446470008600 Sulfatase; Region: Sulfatase; pfam00884 446470008601 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446470008602 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446470008603 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446470008604 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 446470008605 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 446470008606 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 446470008607 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446470008608 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 446470008609 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446470008610 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 446470008611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008612 putative substrate translocation pore; other site 446470008613 Cupin domain; Region: Cupin_2; cl17218 446470008614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470008615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008616 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446470008617 Walker A/P-loop; other site 446470008618 ATP binding site [chemical binding]; other site 446470008619 Q-loop/lid; other site 446470008620 ABC transporter signature motif; other site 446470008621 Walker B; other site 446470008622 D-loop; other site 446470008623 H-loop/switch region; other site 446470008624 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470008625 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470008626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470008627 Walker A/P-loop; other site 446470008628 ATP binding site [chemical binding]; other site 446470008629 Q-loop/lid; other site 446470008630 ABC transporter signature motif; other site 446470008631 Walker B; other site 446470008632 D-loop; other site 446470008633 H-loop/switch region; other site 446470008634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008636 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446470008637 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470008638 DNA binding residues [nucleotide binding] 446470008639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470008641 putative substrate translocation pore; other site 446470008642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008643 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446470008644 Amidase; Region: Amidase; cl11426 446470008645 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470008646 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 446470008647 arginine-tRNA ligase; Region: PLN02286 446470008648 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 446470008649 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446470008650 active site 446470008651 HIGH motif; other site 446470008652 KMSK motif region; other site 446470008653 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446470008654 tRNA binding surface [nucleotide binding]; other site 446470008655 anticodon binding site; other site 446470008656 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446470008657 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 446470008658 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446470008659 trimer interface [polypeptide binding]; other site 446470008660 substrate binding site [chemical binding]; other site 446470008661 Mn binding site [ion binding]; other site 446470008662 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446470008663 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446470008664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 446470008665 metabolite-proton symporter; Region: 2A0106; TIGR00883 446470008666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470008667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470008668 DNA binding site [nucleotide binding] 446470008669 domain linker motif; other site 446470008670 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470008671 ligand binding site [chemical binding]; other site 446470008672 dimerization interface [polypeptide binding]; other site 446470008673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470008674 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470008675 active site 446470008676 catalytic tetrad [active] 446470008677 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 446470008678 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470008679 DNA binding residues [nucleotide binding] 446470008680 putative dimer interface [polypeptide binding]; other site 446470008681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470008683 active site 446470008684 phosphorylation site [posttranslational modification] 446470008685 intermolecular recognition site; other site 446470008686 dimerization interface [polypeptide binding]; other site 446470008687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008688 DNA binding residues [nucleotide binding] 446470008689 dimerization interface [polypeptide binding]; other site 446470008690 Histidine kinase; Region: HisKA_3; pfam07730 446470008691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470008692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470008693 ATP binding site [chemical binding]; other site 446470008694 Mg2+ binding site [ion binding]; other site 446470008695 G-X-G motif; other site 446470008696 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446470008697 EF-hand domain pair; Region: EF_hand_5; pfam13499 446470008698 Ca2+ binding site [ion binding]; other site 446470008699 EF-hand domain pair; Region: EF_hand_5; pfam13499 446470008700 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446470008701 Ca2+ binding site [ion binding]; other site 446470008702 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 446470008703 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 446470008704 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446470008705 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470008706 hypothetical protein; Provisional; Region: PRK07236 446470008707 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470008708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008710 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446470008711 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446470008712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470008713 FeS/SAM binding site; other site 446470008714 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446470008715 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 446470008716 trimer interface [polypeptide binding]; other site 446470008717 dimer interface [polypeptide binding]; other site 446470008718 putative active site [active] 446470008719 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 446470008720 MoaE interaction surface [polypeptide binding]; other site 446470008721 MoeB interaction surface [polypeptide binding]; other site 446470008722 thiocarboxylated glycine; other site 446470008723 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446470008724 MoaE homodimer interface [polypeptide binding]; other site 446470008725 MoaD interaction [polypeptide binding]; other site 446470008726 active site residues [active] 446470008727 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446470008728 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446470008729 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446470008730 VanZ like family; Region: VanZ; pfam04892 446470008731 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470008732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470008733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470008734 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446470008735 NAD(P) binding site [chemical binding]; other site 446470008736 active site 446470008737 putative phosphatase; Provisional; Region: PRK11587 446470008738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470008739 motif II; other site 446470008740 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 446470008741 active site 446470008742 catalytic site [active] 446470008743 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470008744 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470008745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470008746 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470008747 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470008748 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446470008749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470008750 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470008751 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470008752 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470008753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470008754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470008755 DNA binding residues [nucleotide binding] 446470008756 short chain dehydrogenase; Provisional; Region: PRK07890 446470008757 classical (c) SDRs; Region: SDR_c; cd05233 446470008758 NAD(P) binding site [chemical binding]; other site 446470008759 active site 446470008760 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 446470008761 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446470008762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470008763 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 446470008764 inhibitor-cofactor binding pocket; inhibition site 446470008765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470008766 catalytic residue [active] 446470008767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 446470008768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470008769 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470008770 active site 446470008771 catalytic tetrad [active] 446470008772 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446470008773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470008774 DNA-binding site [nucleotide binding]; DNA binding site 446470008775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470008776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470008777 homodimer interface [polypeptide binding]; other site 446470008778 catalytic residue [active] 446470008779 Creatinine amidohydrolase; Region: Creatininase; pfam02633 446470008780 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446470008781 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446470008782 metal binding site [ion binding]; metal-binding site 446470008783 substrate binding pocket [chemical binding]; other site 446470008784 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446470008785 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446470008786 Histidine kinase; Region: HisKA_3; pfam07730 446470008787 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470008788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470008790 active site 446470008791 phosphorylation site [posttranslational modification] 446470008792 intermolecular recognition site; other site 446470008793 dimerization interface [polypeptide binding]; other site 446470008794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008795 dimerization interface [polypeptide binding]; other site 446470008796 DNA binding residues [nucleotide binding] 446470008797 Protein of unknown function (DUF418); Region: DUF418; cl12135 446470008798 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470008799 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470008800 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446470008801 Predicted membrane protein [Function unknown]; Region: COG1511 446470008802 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 446470008803 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446470008804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 446470008805 Walker A/P-loop; other site 446470008806 ATP binding site [chemical binding]; other site 446470008807 Q-loop/lid; other site 446470008808 ABC transporter signature motif; other site 446470008809 Walker B; other site 446470008810 D-loop; other site 446470008811 H-loop/switch region; other site 446470008812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470008815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470008816 DNA binding site [nucleotide binding] 446470008817 domain linker motif; other site 446470008818 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470008819 ligand binding site [chemical binding]; other site 446470008820 dimerization interface [polypeptide binding]; other site 446470008821 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 446470008822 active site 446470008823 catalytic residues [active] 446470008824 DNA binding site [nucleotide binding] 446470008825 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470008826 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470008827 AAA domain; Region: AAA_22; pfam13401 446470008828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470008829 binding surface 446470008830 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470008831 TPR motif; other site 446470008832 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470008833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470008834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470008835 binding surface 446470008836 TPR motif; other site 446470008837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470008838 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 446470008839 Right handed beta helix region; Region: Beta_helix; pfam13229 446470008840 Alginate lyase; Region: Alginate_lyase2; pfam08787 446470008841 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 446470008842 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008844 DNA binding residues [nucleotide binding] 446470008845 AAA ATPase domain; Region: AAA_16; pfam13191 446470008846 Predicted ATPase [General function prediction only]; Region: COG3903 446470008847 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446470008848 FAD binding domain; Region: FAD_binding_4; pfam01565 446470008849 Berberine and berberine like; Region: BBE; pfam08031 446470008850 RibD C-terminal domain; Region: RibD_C; cl17279 446470008851 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470008852 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470008853 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470008854 conserved cys residue [active] 446470008855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470008856 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470008857 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470008858 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446470008859 DNA binding residues [nucleotide binding] 446470008860 dimer interface [polypeptide binding]; other site 446470008861 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 446470008862 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446470008863 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446470008864 substrate binding sites [chemical binding]; other site 446470008865 Right handed beta helix region; Region: Beta_helix; pfam13229 446470008866 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 446470008867 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 446470008868 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 446470008869 catalytic triad [active] 446470008870 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470008871 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470008872 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 446470008873 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 446470008874 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 446470008875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470008876 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446470008877 putative substrate translocation pore; other site 446470008878 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470008879 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470008880 dimerization interface [polypeptide binding]; other site 446470008881 putative DNA binding site [nucleotide binding]; other site 446470008882 putative Zn2+ binding site [ion binding]; other site 446470008883 CAAX protease self-immunity; Region: Abi; pfam02517 446470008884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470008886 active site 446470008887 phosphorylation site [posttranslational modification] 446470008888 intermolecular recognition site; other site 446470008889 dimerization interface [polypeptide binding]; other site 446470008890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008891 DNA binding residues [nucleotide binding] 446470008892 dimerization interface [polypeptide binding]; other site 446470008893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470008894 Histidine kinase; Region: HisKA_3; pfam07730 446470008895 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470008896 CAAX protease self-immunity; Region: Abi; pfam02517 446470008897 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 446470008898 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 446470008899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008901 Cupin domain; Region: Cupin_2; cl17218 446470008902 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470008903 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470008904 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446470008905 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446470008906 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446470008907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470008908 S-adenosylmethionine binding site [chemical binding]; other site 446470008909 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446470008910 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 446470008911 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446470008912 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 446470008913 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 446470008914 acetylornithine deacetylase; Validated; Region: PRK06915 446470008915 metal binding site [ion binding]; metal-binding site 446470008916 dimer interface [polypeptide binding]; other site 446470008917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008919 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446470008920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446470008921 Carboxylesterase family; Region: COesterase; pfam00135 446470008922 substrate binding pocket [chemical binding]; other site 446470008923 catalytic triad [active] 446470008924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470008925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470008926 active site 446470008927 catalytic tetrad [active] 446470008928 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470008929 DinB superfamily; Region: DinB_2; pfam12867 446470008930 RDD family; Region: RDD; pfam06271 446470008931 heat shock protein HtpX; Provisional; Region: PRK03072 446470008932 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470008933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470008934 NB-ARC domain; Region: NB-ARC; pfam00931 446470008935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470008936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470008937 TPR motif; other site 446470008938 binding surface 446470008939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470008940 binding surface 446470008941 TPR motif; other site 446470008942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470008943 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 446470008944 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470008945 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470008946 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 446470008947 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 446470008948 dimer interface [polypeptide binding]; other site 446470008949 catalytic triad [active] 446470008950 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 446470008951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470008952 ATP binding site [chemical binding]; other site 446470008953 putative Mg++ binding site [ion binding]; other site 446470008954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470008955 nucleotide binding region [chemical binding]; other site 446470008956 ATP-binding site [chemical binding]; other site 446470008957 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446470008958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470008959 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470008960 DNA binding site [nucleotide binding] 446470008961 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470008962 Protein of unknown function, DUF488; Region: DUF488; pfam04343 446470008963 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446470008964 homotrimer interaction site [polypeptide binding]; other site 446470008965 putative active site [active] 446470008966 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470008967 HTH domain; Region: HTH_11; pfam08279 446470008968 WYL domain; Region: WYL; pfam13280 446470008969 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470008970 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446470008971 putative NAD(P) binding site [chemical binding]; other site 446470008972 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470008973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470008974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470008975 DNA binding residues [nucleotide binding] 446470008976 dimerization interface [polypeptide binding]; other site 446470008977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470008978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470008979 putative Zn2+ binding site [ion binding]; other site 446470008980 putative DNA binding site [nucleotide binding]; other site 446470008981 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 446470008982 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446470008983 Lysine efflux permease [General function prediction only]; Region: COG1279 446470008984 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 446470008985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470008986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446470008987 dimerization interface [polypeptide binding]; other site 446470008988 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 446470008989 NmrA-like family; Region: NmrA; pfam05368 446470008990 NADP binding site [chemical binding]; other site 446470008991 active site 446470008992 regulatory binding site [polypeptide binding]; other site 446470008993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470008994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470008995 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446470008996 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446470008997 active site 446470008998 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 446470008999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 446470009000 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470009001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470009002 DNA binding residues [nucleotide binding] 446470009003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470009004 Coenzyme A binding pocket [chemical binding]; other site 446470009005 AAA ATPase domain; Region: AAA_16; pfam13191 446470009006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009007 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009008 DNA binding residues [nucleotide binding] 446470009009 dimerization interface [polypeptide binding]; other site 446470009010 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 446470009011 homodimer interaction site [polypeptide binding]; other site 446470009012 cofactor binding site; other site 446470009013 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470009014 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470009015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009016 dimerization interface [polypeptide binding]; other site 446470009017 putative DNA binding site [nucleotide binding]; other site 446470009018 putative Zn2+ binding site [ion binding]; other site 446470009019 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470009020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470009021 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446470009022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446470009023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009024 dimerization interface [polypeptide binding]; other site 446470009025 putative DNA binding site [nucleotide binding]; other site 446470009026 putative Zn2+ binding site [ion binding]; other site 446470009027 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446470009028 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446470009029 active site 446470009030 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009031 putative DNA binding site [nucleotide binding]; other site 446470009032 dimerization interface [polypeptide binding]; other site 446470009033 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470009034 putative Zn2+ binding site [ion binding]; other site 446470009035 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446470009036 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446470009037 active site 446470009038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009039 dimerization interface [polypeptide binding]; other site 446470009040 putative DNA binding site [nucleotide binding]; other site 446470009041 putative Zn2+ binding site [ion binding]; other site 446470009042 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446470009043 arsenical-resistance protein; Region: acr3; TIGR00832 446470009044 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 446470009045 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 446470009046 nickel binding site [ion binding]; other site 446470009047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009048 Ligand Binding Site [chemical binding]; other site 446470009049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009050 Ligand Binding Site [chemical binding]; other site 446470009051 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470009052 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470009053 ligand binding site [chemical binding]; other site 446470009054 flexible hinge region; other site 446470009055 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446470009056 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446470009057 putative dimer interface [polypeptide binding]; other site 446470009058 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446470009059 Domain of unknown function (DUF377); Region: DUF377; pfam04041 446470009060 active site 446470009061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470009062 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 446470009063 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446470009064 Domain of unknown function (DUF377); Region: DUF377; pfam04041 446470009065 active site 446470009066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009067 Ligand Binding Site [chemical binding]; other site 446470009068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009069 Ligand Binding Site [chemical binding]; other site 446470009070 Predicted membrane protein [Function unknown]; Region: COG3462 446470009071 Short C-terminal domain; Region: SHOCT; pfam09851 446470009072 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 446470009073 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 446470009074 dimerization interface [polypeptide binding]; other site 446470009075 ATP binding site [chemical binding]; other site 446470009076 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 446470009077 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 446470009078 HupF/HypC family; Region: HupF_HypC; pfam01455 446470009079 Acylphosphatase; Region: Acylphosphatase; pfam00708 446470009080 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 446470009081 HypF finger; Region: zf-HYPF; pfam07503 446470009082 HypF finger; Region: zf-HYPF; pfam07503 446470009083 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 446470009084 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009085 Ligand Binding Site [chemical binding]; other site 446470009086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009087 Ligand Binding Site [chemical binding]; other site 446470009088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470009089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470009090 Coenzyme A binding pocket [chemical binding]; other site 446470009091 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 446470009092 CoA binding domain; Region: CoA_binding_2; pfam13380 446470009093 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446470009094 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446470009095 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 446470009096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446470009097 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 446470009098 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 446470009099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470009100 motif II; other site 446470009101 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 446470009102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009103 Ligand Binding Site [chemical binding]; other site 446470009104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009105 Ligand Binding Site [chemical binding]; other site 446470009106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009107 Ligand Binding Site [chemical binding]; other site 446470009108 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009109 Ligand Binding Site [chemical binding]; other site 446470009110 V-type ATP synthase subunit I; Validated; Region: PRK05771 446470009111 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 446470009112 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 446470009113 V-type ATP synthase subunit A; Provisional; Region: PRK04192 446470009114 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 446470009115 Walker A motif/ATP binding site; other site 446470009116 Walker B motif; other site 446470009117 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446470009118 V-type ATP synthase subunit B; Provisional; Region: PRK04196 446470009119 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 446470009120 Walker A motif homologous position; other site 446470009121 Walker B motif; other site 446470009122 ATP synthase subunit D; Region: ATP-synt_D; cl00613 446470009123 acetyl-CoA synthetase; Provisional; Region: PRK04319 446470009124 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 446470009125 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 446470009126 active site 446470009127 acyl-activating enzyme (AAE) consensus motif; other site 446470009128 putative CoA binding site [chemical binding]; other site 446470009129 AMP binding site [chemical binding]; other site 446470009130 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 446470009131 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446470009132 tetramer interface [polypeptide binding]; other site 446470009133 TPP-binding site [chemical binding]; other site 446470009134 heterodimer interface [polypeptide binding]; other site 446470009135 phosphorylation loop region [posttranslational modification] 446470009136 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446470009137 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446470009138 alpha subunit interface [polypeptide binding]; other site 446470009139 TPP binding site [chemical binding]; other site 446470009140 heterodimer interface [polypeptide binding]; other site 446470009141 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446470009142 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446470009143 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446470009144 E3 interaction surface; other site 446470009145 lipoyl attachment site [posttranslational modification]; other site 446470009146 e3 binding domain; Region: E3_binding; pfam02817 446470009147 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446470009148 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446470009149 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446470009150 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 446470009151 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 446470009152 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 446470009153 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 446470009154 FAD binding pocket [chemical binding]; other site 446470009155 FAD binding motif [chemical binding]; other site 446470009156 phosphate binding motif [ion binding]; other site 446470009157 beta-alpha-beta structure motif; other site 446470009158 NAD binding pocket [chemical binding]; other site 446470009159 Iron coordination center [ion binding]; other site 446470009160 coenzyme F420 hydrogenase, subunit gamma; Region: FrhG; TIGR03294 446470009161 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 446470009162 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 446470009163 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009164 Ligand Binding Site [chemical binding]; other site 446470009165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009166 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009167 Ligand Binding Site [chemical binding]; other site 446470009168 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009169 Ligand Binding Site [chemical binding]; other site 446470009170 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446470009171 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470009172 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470009173 Helix-turn-helix domain; Region: HTH_31; pfam13560 446470009174 Predicted ATPase [General function prediction only]; Region: COG3903 446470009175 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470009176 DNA binding site [nucleotide binding] 446470009177 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470009178 AAA ATPase domain; Region: AAA_16; pfam13191 446470009179 NB-ARC domain; Region: NB-ARC; pfam00931 446470009180 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 446470009181 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 446470009182 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 446470009183 active site 446470009184 zinc binding site [ion binding]; other site 446470009185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470009186 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470009187 Walker A/P-loop; other site 446470009188 ATP binding site [chemical binding]; other site 446470009189 Q-loop/lid; other site 446470009190 ABC transporter signature motif; other site 446470009191 Walker B; other site 446470009192 D-loop; other site 446470009193 H-loop/switch region; other site 446470009194 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446470009195 FAD binding domain; Region: FAD_binding_4; pfam01565 446470009196 Berberine and berberine like; Region: BBE; pfam08031 446470009197 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470009198 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470009199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470009200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470009201 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470009202 dimerization interface [polypeptide binding]; other site 446470009203 substrate binding pocket [chemical binding]; other site 446470009204 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446470009205 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 446470009206 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446470009207 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 446470009208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470009209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470009210 metal binding site [ion binding]; metal-binding site 446470009211 active site 446470009212 I-site; other site 446470009213 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446470009214 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 446470009215 active site pocket [active] 446470009216 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446470009217 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 446470009218 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 446470009219 active site 446470009220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470009221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470009222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470009223 putative dimerization interface [polypeptide binding]; other site 446470009224 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446470009225 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470009226 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470009227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470009228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470009229 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446470009230 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470009231 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 446470009232 active site 446470009233 catalytic triad [active] 446470009234 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 446470009235 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 446470009236 dimerization interface [polypeptide binding]; other site 446470009237 DNA binding residues [nucleotide binding] 446470009238 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446470009239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470009240 acyl-activating enzyme (AAE) consensus motif; other site 446470009241 AMP binding site [chemical binding]; other site 446470009242 active site 446470009243 CoA binding site [chemical binding]; other site 446470009244 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446470009245 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446470009246 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446470009247 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446470009248 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446470009249 putative active site [active] 446470009250 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446470009251 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 446470009252 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470009253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470009254 dimer interface [polypeptide binding]; other site 446470009255 ABC-ATPase subunit interface; other site 446470009256 putative PBP binding loops; other site 446470009257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470009258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470009259 ABC-ATPase subunit interface; other site 446470009260 putative PBP binding loops; other site 446470009261 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 446470009262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470009263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470009264 Coenzyme A binding pocket [chemical binding]; other site 446470009265 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470009266 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470009267 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446470009268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470009269 Walker A/P-loop; other site 446470009270 ATP binding site [chemical binding]; other site 446470009271 Q-loop/lid; other site 446470009272 ABC transporter signature motif; other site 446470009273 Walker B; other site 446470009274 D-loop; other site 446470009275 H-loop/switch region; other site 446470009276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470009277 Walker A/P-loop; other site 446470009278 ATP binding site [chemical binding]; other site 446470009279 Q-loop/lid; other site 446470009280 ABC transporter signature motif; other site 446470009281 Walker B; other site 446470009282 D-loop; other site 446470009283 H-loop/switch region; other site 446470009284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470009285 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446470009286 hypothetical protein; Provisional; Region: PRK06815 446470009287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470009288 catalytic residue [active] 446470009289 BNR repeat-like domain; Region: BNR_2; pfam13088 446470009290 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 446470009291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470009292 MarR family; Region: MarR; pfam01047 446470009293 hypothetical protein; Provisional; Region: PRK06753 446470009294 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470009295 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446470009296 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446470009297 siderophore binding site; other site 446470009298 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470009299 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470009300 ABC-ATPase subunit interface; other site 446470009301 dimer interface [polypeptide binding]; other site 446470009302 putative PBP binding regions; other site 446470009303 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470009304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470009305 ABC-ATPase subunit interface; other site 446470009306 dimer interface [polypeptide binding]; other site 446470009307 putative PBP binding regions; other site 446470009308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009310 DNA binding residues [nucleotide binding] 446470009311 dimerization interface [polypeptide binding]; other site 446470009312 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470009313 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 446470009314 NB-ARC domain; Region: NB-ARC; pfam00931 446470009315 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446470009316 active site 446470009317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470009318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009319 binding surface 446470009320 TPR motif; other site 446470009321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470009322 TPR motif; other site 446470009323 binding surface 446470009324 TPR repeat; Region: TPR_11; pfam13414 446470009325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446470009326 binding surface 446470009327 TPR motif; other site 446470009328 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009329 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 446470009330 putative active site [active] 446470009331 catalytic site [active] 446470009332 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 446470009333 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446470009334 YCII-related domain; Region: YCII; cl00999 446470009335 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470009336 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470009337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009338 putative DNA binding site [nucleotide binding]; other site 446470009339 dimerization interface [polypeptide binding]; other site 446470009340 putative Zn2+ binding site [ion binding]; other site 446470009341 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446470009342 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446470009343 active site 446470009344 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470009345 nudix motif; other site 446470009346 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470009347 TIGR03086 family protein; Region: TIGR03086 446470009348 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446470009349 putative hydrophobic ligand binding site [chemical binding]; other site 446470009350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009351 putative Zn2+ binding site [ion binding]; other site 446470009352 putative DNA binding site [nucleotide binding]; other site 446470009353 TIGR03086 family protein; Region: TIGR03086 446470009354 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470009355 PhoD-like phosphatase; Region: PhoD; pfam09423 446470009356 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446470009357 putative active site [active] 446470009358 putative metal binding site [ion binding]; other site 446470009359 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470009360 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470009361 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470009362 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470009363 structural tetrad; other site 446470009364 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470009365 nucleotide binding site [chemical binding]; other site 446470009366 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470009367 SBD interface [polypeptide binding]; other site 446470009368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470009369 active site 446470009370 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470009371 TIGR02452 family protein; Region: TIGR02452 446470009372 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 446470009373 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470009374 RibD C-terminal domain; Region: RibD_C; cl17279 446470009375 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446470009376 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446470009377 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470009378 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470009379 active site 446470009380 ATP binding site [chemical binding]; other site 446470009381 substrate binding site [chemical binding]; other site 446470009382 activation loop (A-loop); other site 446470009383 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470009384 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470009385 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470009386 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446470009387 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470009388 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470009389 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 446470009390 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470009391 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470009392 RibD C-terminal domain; Region: RibD_C; cl17279 446470009393 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470009394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009396 DNA binding residues [nucleotide binding] 446470009397 dimerization interface [polypeptide binding]; other site 446470009398 Predicted ATPase [General function prediction only]; Region: COG3903 446470009399 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446470009400 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446470009401 putative dimer interface [polypeptide binding]; other site 446470009402 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470009403 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470009404 DNA binding residues [nucleotide binding] 446470009405 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 446470009406 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 446470009407 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 446470009408 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 446470009409 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 446470009410 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 446470009411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446470009412 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 446470009413 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446470009414 active site 446470009415 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446470009416 generic binding surface II; other site 446470009417 generic binding surface I; other site 446470009418 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446470009419 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 446470009420 catalytic residues [active] 446470009421 catalytic nucleophile [active] 446470009422 Recombinase; Region: Recombinase; pfam07508 446470009423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470009424 binding surface 446470009425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009426 TPR motif; other site 446470009427 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009429 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470009430 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470009431 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446470009432 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446470009433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470009434 CHAT domain; Region: CHAT; cl17868 446470009435 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446470009436 metal ion-dependent adhesion site (MIDAS); other site 446470009437 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 446470009438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470009439 Walker A motif; other site 446470009440 ATP binding site [chemical binding]; other site 446470009441 Walker B motif; other site 446470009442 arginine finger; other site 446470009443 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470009444 structural tetrad; other site 446470009445 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470009446 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470009447 structural tetrad; other site 446470009448 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 446470009449 FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363 446470009450 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 446470009451 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 446470009452 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446470009453 active site 446470009454 zinc binding site [ion binding]; other site 446470009455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470009456 NACHT domain; Region: NACHT; pfam05729 446470009457 Walker A motif; other site 446470009458 ATP binding site [chemical binding]; other site 446470009459 Domain of unknown function (DUF932); Region: DUF932; cl12129 446470009460 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 446470009461 AAA domain; Region: AAA_30; pfam13604 446470009462 AAA domain; Region: AAA_22; pfam13401 446470009463 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446470009464 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446470009465 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470009466 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 446470009467 putative substrate binding site [chemical binding]; other site 446470009468 putative ATP binding site [chemical binding]; other site 446470009469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470009470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470009471 DNA binding site [nucleotide binding] 446470009472 domain linker motif; other site 446470009473 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470009474 dimerization interface [polypeptide binding]; other site 446470009475 ligand binding site [chemical binding]; other site 446470009476 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 446470009477 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 446470009478 ligand binding site [chemical binding]; other site 446470009479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470009480 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470009481 TM-ABC transporter signature motif; other site 446470009482 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446470009483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470009484 Walker A/P-loop; other site 446470009485 ATP binding site [chemical binding]; other site 446470009486 Q-loop/lid; other site 446470009487 ABC transporter signature motif; other site 446470009488 Walker B; other site 446470009489 D-loop; other site 446470009490 H-loop/switch region; other site 446470009491 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 446470009492 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 446470009493 substrate binding [chemical binding]; other site 446470009494 active site 446470009495 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 446470009496 Uncharacterized conserved protein [Function unknown]; Region: COG4127 446470009497 Restriction endonuclease; Region: Mrr_cat; pfam04471 446470009498 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446470009499 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 446470009500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470009501 sequence-specific DNA binding site [nucleotide binding]; other site 446470009502 salt bridge; other site 446470009503 NB-ARC domain; Region: NB-ARC; pfam00931 446470009504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009505 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470009508 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470009510 active site 446470009511 phosphorylation site [posttranslational modification] 446470009512 intermolecular recognition site; other site 446470009513 dimerization interface [polypeptide binding]; other site 446470009514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009515 DNA binding residues [nucleotide binding] 446470009516 dimerization interface [polypeptide binding]; other site 446470009517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470009518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470009519 ATP binding site [chemical binding]; other site 446470009520 Mg2+ binding site [ion binding]; other site 446470009521 G-X-G motif; other site 446470009522 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470009523 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 446470009524 dimer interface [polypeptide binding]; other site 446470009525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470009526 ligand binding site [chemical binding]; other site 446470009527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470009528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470009529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446470009530 MMPL family; Region: MMPL; pfam03176 446470009531 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 446470009532 phosphopeptide binding site; other site 446470009533 HTH DNA binding domain; Region: HTH_10; pfam04967 446470009534 Protein kinase; unclassified specificity; Region: STYKc; smart00221 446470009535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470009536 active site 446470009537 ATP binding site [chemical binding]; other site 446470009538 substrate binding site [chemical binding]; other site 446470009539 activation loop (A-loop); other site 446470009540 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470009541 MarR family; Region: MarR_2; cl17246 446470009542 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470009543 active site 446470009544 metal binding site [ion binding]; metal-binding site 446470009545 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470009546 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470009547 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470009548 ligand binding site [chemical binding]; other site 446470009549 flexible hinge region; other site 446470009550 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446470009551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470009552 Coenzyme A binding pocket [chemical binding]; other site 446470009553 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446470009554 CoA binding domain; Region: CoA_binding_2; pfam13380 446470009555 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446470009556 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446470009557 Predicted membrane protein [Function unknown]; Region: COG3462 446470009558 Short C-terminal domain; Region: SHOCT; pfam09851 446470009559 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009560 Ligand Binding Site [chemical binding]; other site 446470009561 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009562 Ligand Binding Site [chemical binding]; other site 446470009563 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009564 Ligand Binding Site [chemical binding]; other site 446470009565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009566 Ligand Binding Site [chemical binding]; other site 446470009567 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009568 Ligand Binding Site [chemical binding]; other site 446470009569 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470009570 Ligand Binding Site [chemical binding]; other site 446470009571 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 446470009572 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 446470009573 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446470009574 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 446470009575 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446470009576 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 446470009577 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446470009578 dimer interface [polypeptide binding]; other site 446470009579 Flavodoxin domain; Region: Flavodoxin_5; cl17428 446470009580 MarR family; Region: MarR_2; cl17246 446470009581 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446470009582 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446470009583 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470009584 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446470009585 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470009586 Walker A/P-loop; other site 446470009587 ATP binding site [chemical binding]; other site 446470009588 Q-loop/lid; other site 446470009589 ABC transporter signature motif; other site 446470009590 Walker B; other site 446470009591 D-loop; other site 446470009592 H-loop/switch region; other site 446470009593 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446470009594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470009595 potassium/proton antiporter; Reviewed; Region: PRK05326 446470009596 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 446470009597 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 446470009598 transmembrane helices; other site 446470009599 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446470009600 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446470009601 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 446470009602 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470009603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470009604 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470009605 DNA binding residues [nucleotide binding] 446470009606 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470009607 nucleotide binding site [chemical binding]; other site 446470009608 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470009609 SBD interface [polypeptide binding]; other site 446470009610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470009612 active site 446470009613 phosphorylation site [posttranslational modification] 446470009614 intermolecular recognition site; other site 446470009615 dimerization interface [polypeptide binding]; other site 446470009616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009617 DNA binding residues [nucleotide binding] 446470009618 dimerization interface [polypeptide binding]; other site 446470009619 Histidine kinase; Region: HisKA_3; pfam07730 446470009620 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470009621 ATP binding site [chemical binding]; other site 446470009622 Mg2+ binding site [ion binding]; other site 446470009623 G-X-G motif; other site 446470009624 short chain dehydrogenase; Provisional; Region: PRK06172 446470009625 classical (c) SDRs; Region: SDR_c; cd05233 446470009626 NAD(P) binding site [chemical binding]; other site 446470009627 active site 446470009628 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470009629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470009630 putative DNA binding site [nucleotide binding]; other site 446470009631 putative Zn2+ binding site [ion binding]; other site 446470009632 WYL domain; Region: WYL; pfam13280 446470009633 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446470009634 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446470009635 DinB superfamily; Region: DinB_2; pfam12867 446470009636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470009637 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470009638 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470009639 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470009640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470009642 binding surface 446470009643 TPR motif; other site 446470009644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009645 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470009647 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 446470009648 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 446470009649 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 446470009650 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446470009651 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446470009652 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446470009653 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470009654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470009655 S-adenosylmethionine binding site [chemical binding]; other site 446470009656 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446470009657 TM-ABC transporter signature motif; other site 446470009658 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446470009659 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446470009660 TM-ABC transporter signature motif; other site 446470009661 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446470009662 Nitrate and nitrite sensing; Region: NIT; pfam08376 446470009663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470009664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470009665 ATP binding site [chemical binding]; other site 446470009666 Mg2+ binding site [ion binding]; other site 446470009667 G-X-G motif; other site 446470009668 Ricin-type beta-trefoil; Region: RICIN; smart00458 446470009669 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446470009670 putative sugar binding sites [chemical binding]; other site 446470009671 Q-X-W motif; other site 446470009672 RibD C-terminal domain; Region: RibD_C; cl17279 446470009673 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446470009674 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446470009675 active site 446470009676 catalytic site [active] 446470009677 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470009678 Domain of unknown function (DUF427); Region: DUF427; pfam04248 446470009679 Domain of unknown function (DUF427); Region: DUF427; pfam04248 446470009680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470009681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470009682 DNA binding site [nucleotide binding] 446470009683 domain linker motif; other site 446470009684 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470009685 ligand binding site [chemical binding]; other site 446470009686 dimerization interface [polypeptide binding]; other site 446470009687 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446470009688 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446470009689 Walker A/P-loop; other site 446470009690 ATP binding site [chemical binding]; other site 446470009691 Q-loop/lid; other site 446470009692 ABC transporter signature motif; other site 446470009693 Walker B; other site 446470009694 D-loop; other site 446470009695 H-loop/switch region; other site 446470009696 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446470009697 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470009698 TM-ABC transporter signature motif; other site 446470009699 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470009700 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470009701 TM-ABC transporter signature motif; other site 446470009702 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 446470009703 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 446470009704 ligand binding site [chemical binding]; other site 446470009705 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 446470009706 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446470009707 short chain dehydrogenase; Validated; Region: PRK08324 446470009708 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 446470009709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470009710 NAD(P) binding site [chemical binding]; other site 446470009711 active site 446470009712 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 446470009713 N- and C-terminal domain interface [polypeptide binding]; other site 446470009714 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 446470009715 active site 446470009716 putative catalytic site [active] 446470009717 metal binding site [ion binding]; metal-binding site 446470009718 ATP binding site [chemical binding]; other site 446470009719 carbohydrate binding site [chemical binding]; other site 446470009720 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 446470009721 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446470009722 phosphate binding site [ion binding]; other site 446470009723 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 446470009724 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 446470009725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470009726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446470009727 TPR motif; other site 446470009728 N-terminal domain of SATB1 and similar proteins; Region: SATB1_N; cd11585 446470009729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470009731 active site 446470009732 phosphorylation site [posttranslational modification] 446470009733 intermolecular recognition site; other site 446470009734 dimerization interface [polypeptide binding]; other site 446470009735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009736 DNA binding residues [nucleotide binding] 446470009737 dimerization interface [polypeptide binding]; other site 446470009738 Histidine kinase; Region: HisKA_3; pfam07730 446470009739 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470009740 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446470009741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470009742 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470009743 MarR family; Region: MarR_2; pfam12802 446470009744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470009745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470009746 Coenzyme A binding pocket [chemical binding]; other site 446470009747 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446470009748 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446470009749 catalytic site [active] 446470009750 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446470009751 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446470009752 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 446470009753 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446470009754 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470009755 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470009756 putative acyl-acceptor binding pocket; other site 446470009757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009759 DNA binding residues [nucleotide binding] 446470009760 dimerization interface [polypeptide binding]; other site 446470009761 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446470009762 Dynamin family; Region: Dynamin_N; pfam00350 446470009763 G1 box; other site 446470009764 GTP/Mg2+ binding site [chemical binding]; other site 446470009765 G2 box; other site 446470009766 Switch I region; other site 446470009767 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 446470009768 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446470009769 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446470009770 Dynamin family; Region: Dynamin_N; pfam00350 446470009771 G1 box; other site 446470009772 GTP/Mg2+ binding site [chemical binding]; other site 446470009773 G2 box; other site 446470009774 Switch I region; other site 446470009775 G3 box; other site 446470009776 Switch II region; other site 446470009777 G4 box; other site 446470009778 G5 box; other site 446470009779 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446470009780 putative active site [active] 446470009781 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446470009782 HSP70 interaction site [polypeptide binding]; other site 446470009783 IucA / IucC family; Region: IucA_IucC; pfam04183 446470009784 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 446470009785 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 446470009786 IucA / IucC family; Region: IucA_IucC; pfam04183 446470009787 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 446470009788 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 446470009789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 446470009790 dimer interface [polypeptide binding]; other site 446470009791 active site 446470009792 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446470009793 catalytic residues [active] 446470009794 substrate binding site [chemical binding]; other site 446470009795 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446470009796 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446470009797 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446470009798 metal ion-dependent adhesion site (MIDAS); other site 446470009799 glycine dehydrogenase; Provisional; Region: PRK05367 446470009800 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470009801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470009802 catalytic residue [active] 446470009803 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 446470009804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470009805 catalytic residue [active] 446470009806 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 446470009807 DNA binding residues [nucleotide binding] 446470009808 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470009809 putative dimer interface [polypeptide binding]; other site 446470009810 Bifunctional nuclease; Region: DNase-RNase; pfam02577 446470009811 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446470009812 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446470009813 phosphopeptide binding site; other site 446470009814 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446470009815 lipoyl attachment site [posttranslational modification]; other site 446470009816 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446470009817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470009818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470009819 active site 446470009820 phosphorylation site [posttranslational modification] 446470009821 intermolecular recognition site; other site 446470009822 dimerization interface [polypeptide binding]; other site 446470009823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470009824 DNA binding residues [nucleotide binding] 446470009825 dimerization interface [polypeptide binding]; other site 446470009826 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446470009827 GAF domain; Region: GAF; pfam01590 446470009828 Histidine kinase; Region: HisKA_3; pfam07730 446470009829 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446470009830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470009831 ATP binding site [chemical binding]; other site 446470009832 Mg2+ binding site [ion binding]; other site 446470009833 G-X-G motif; other site 446470009834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470009835 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470009836 active site 446470009837 catalytic tetrad [active] 446470009838 PAC2 family; Region: PAC2; pfam09754 446470009839 classical (c) SDRs; Region: SDR_c; cd05233 446470009840 NAD(P) binding site [chemical binding]; other site 446470009841 active site 446470009842 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 446470009843 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 446470009844 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470009845 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470009846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470009847 MarR family; Region: MarR_2; pfam12802 446470009848 hypothetical protein; Provisional; Region: PRK08204 446470009849 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470009850 active site 446470009851 oxidoreductase; Provisional; Region: PRK06196 446470009852 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446470009853 putative NAD(P) binding site [chemical binding]; other site 446470009854 active site 446470009855 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 446470009856 active site 446470009857 catalytic site [active] 446470009858 putative metal binding site [ion binding]; other site 446470009859 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 446470009860 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446470009861 active site 446470009862 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470009863 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470009864 Integral membrane protein TerC family; Region: TerC; cl10468 446470009865 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470009866 DinB superfamily; Region: DinB_2; pfam12867 446470009867 excinuclease ABC subunit B; Provisional; Region: PRK05298 446470009868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470009869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470009870 nucleotide binding region [chemical binding]; other site 446470009871 ATP-binding site [chemical binding]; other site 446470009872 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446470009873 UvrB/uvrC motif; Region: UVR; pfam02151 446470009874 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 446470009875 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446470009876 CoA-binding site [chemical binding]; other site 446470009877 ATP-binding [chemical binding]; other site 446470009878 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 446470009879 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470009880 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470009881 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446470009882 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446470009883 RNA binding site [nucleotide binding]; other site 446470009884 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446470009885 RNA binding site [nucleotide binding]; other site 446470009886 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446470009887 RNA binding site [nucleotide binding]; other site 446470009888 S1 RNA binding domain; Region: S1; pfam00575 446470009889 RNA binding site [nucleotide binding]; other site 446470009890 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446470009891 OpgC protein; Region: OpgC_C; cl17858 446470009892 DNA polymerase I; Provisional; Region: PRK05755 446470009893 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446470009894 active site 446470009895 metal binding site 1 [ion binding]; metal-binding site 446470009896 putative 5' ssDNA interaction site; other site 446470009897 metal binding site 3; metal-binding site 446470009898 metal binding site 2 [ion binding]; metal-binding site 446470009899 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446470009900 putative DNA binding site [nucleotide binding]; other site 446470009901 putative metal binding site [ion binding]; other site 446470009902 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 446470009903 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446470009904 active site 446470009905 DNA binding site [nucleotide binding] 446470009906 catalytic site [active] 446470009907 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446470009908 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446470009909 Walker A/P-loop; other site 446470009910 ATP binding site [chemical binding]; other site 446470009911 Q-loop/lid; other site 446470009912 ABC transporter signature motif; other site 446470009913 Walker B; other site 446470009914 D-loop; other site 446470009915 H-loop/switch region; other site 446470009916 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446470009917 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446470009918 Walker A/P-loop; other site 446470009919 ATP binding site [chemical binding]; other site 446470009920 Q-loop/lid; other site 446470009921 ABC transporter signature motif; other site 446470009922 Walker B; other site 446470009923 D-loop; other site 446470009924 H-loop/switch region; other site 446470009925 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470009926 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446470009927 TM-ABC transporter signature motif; other site 446470009928 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470009929 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446470009930 TM-ABC transporter signature motif; other site 446470009931 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446470009932 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 446470009933 dimerization interface [polypeptide binding]; other site 446470009934 ligand binding site [chemical binding]; other site 446470009935 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446470009936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470009937 active site 446470009938 phosphorylation site [posttranslational modification] 446470009939 intermolecular recognition site; other site 446470009940 dimerization interface [polypeptide binding]; other site 446470009941 ANTAR domain; Region: ANTAR; pfam03861 446470009942 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470009943 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 446470009944 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470009945 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446470009946 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446470009947 Predicted transcriptional regulator [Transcription]; Region: COG1959 446470009948 Transcriptional regulator; Region: Rrf2; pfam02082 446470009949 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470009950 DNA binding site [nucleotide binding] 446470009951 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470009952 AAA ATPase domain; Region: AAA_16; pfam13191 446470009953 NB-ARC domain; Region: NB-ARC; pfam00931 446470009954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446470009955 binding surface 446470009956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470009957 TPR motif; other site 446470009958 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470009959 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470009960 Walker A/P-loop; other site 446470009961 ATP binding site [chemical binding]; other site 446470009962 Q-loop/lid; other site 446470009963 ABC transporter signature motif; other site 446470009964 Walker B; other site 446470009965 D-loop; other site 446470009966 H-loop/switch region; other site 446470009967 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446470009968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470009969 ABC-ATPase subunit interface; other site 446470009970 dimer interface [polypeptide binding]; other site 446470009971 putative PBP binding regions; other site 446470009972 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470009973 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470009974 ABC-ATPase subunit interface; other site 446470009975 dimer interface [polypeptide binding]; other site 446470009976 putative PBP binding regions; other site 446470009977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446470009978 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446470009979 intersubunit interface [polypeptide binding]; other site 446470009980 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446470009981 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446470009982 FAD binding pocket [chemical binding]; other site 446470009983 FAD binding motif [chemical binding]; other site 446470009984 phosphate binding motif [ion binding]; other site 446470009985 NAD binding pocket [chemical binding]; other site 446470009986 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470009987 MarR family; Region: MarR_2; pfam12802 446470009988 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 446470009989 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446470009990 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446470009991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 446470009992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470009993 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470009994 putative substrate translocation pore; other site 446470009995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470009996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470009997 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470009998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470009999 Coenzyme A binding pocket [chemical binding]; other site 446470010000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470010001 MarR family; Region: MarR_2; cl17246 446470010002 Predicted flavoprotein [General function prediction only]; Region: COG0431 446470010003 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446470010004 Hemerythrin-like domain; Region: Hr-like; cd12108 446470010005 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 446470010006 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470010007 DNA binding site [nucleotide binding] 446470010008 NB-ARC domain; Region: NB-ARC; pfam00931 446470010009 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 446470010010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010011 binding surface 446470010012 TPR motif; other site 446470010013 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010015 TPR motif; other site 446470010016 Predicted thioesterase [General function prediction only]; Region: COG5496 446470010017 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446470010018 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446470010019 active site 446470010020 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446470010021 catalytic triad [active] 446470010022 dimer interface [polypeptide binding]; other site 446470010023 pyruvate kinase; Provisional; Region: PRK06247 446470010024 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 446470010025 domain interfaces; other site 446470010026 active site 446470010027 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 446470010028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470010029 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 446470010030 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 446470010031 active site 446470010032 dimer interface [polypeptide binding]; other site 446470010033 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 446470010034 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 446470010035 active site 446470010036 FMN binding site [chemical binding]; other site 446470010037 substrate binding site [chemical binding]; other site 446470010038 3Fe-4S cluster binding site [ion binding]; other site 446470010039 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 446470010040 domain interface; other site 446470010041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470010042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470010043 active site 446470010044 phosphorylation site [posttranslational modification] 446470010045 intermolecular recognition site; other site 446470010046 dimerization interface [polypeptide binding]; other site 446470010047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470010048 DNA binding residues [nucleotide binding] 446470010049 dimerization interface [polypeptide binding]; other site 446470010050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470010051 Histidine kinase; Region: HisKA_3; pfam07730 446470010052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470010053 ATP binding site [chemical binding]; other site 446470010054 Mg2+ binding site [ion binding]; other site 446470010055 G-X-G motif; other site 446470010056 Domain of unknown function (DUF336); Region: DUF336; pfam03928 446470010057 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446470010058 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446470010059 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446470010060 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446470010061 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446470010062 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 446470010063 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 446470010064 dimer interface [polypeptide binding]; other site 446470010065 motif 1; other site 446470010066 active site 446470010067 motif 2; other site 446470010068 motif 3; other site 446470010069 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446470010070 anticodon binding site; other site 446470010071 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446470010072 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446470010073 active site 446470010074 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446470010075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446470010076 Zn2+ binding site [ion binding]; other site 446470010077 Mg2+ binding site [ion binding]; other site 446470010078 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446470010079 synthetase active site [active] 446470010080 NTP binding site [chemical binding]; other site 446470010081 metal binding site [ion binding]; metal-binding site 446470010082 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446470010083 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446470010084 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 446470010085 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 446470010086 Protein export membrane protein; Region: SecD_SecF; pfam02355 446470010087 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 446470010088 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 446470010089 Preprotein translocase subunit; Region: YajC; pfam02699 446470010090 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446470010091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470010092 Walker A motif; other site 446470010093 ATP binding site [chemical binding]; other site 446470010094 Walker B motif; other site 446470010095 arginine finger; other site 446470010096 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446470010097 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446470010098 RuvA N terminal domain; Region: RuvA_N; pfam01330 446470010099 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 446470010100 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 446470010101 active site 446470010102 putative DNA-binding cleft [nucleotide binding]; other site 446470010103 dimer interface [polypeptide binding]; other site 446470010104 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446470010105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470010106 Coenzyme A binding pocket [chemical binding]; other site 446470010107 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 446470010108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470010109 putative substrate translocation pore; other site 446470010110 Uncharacterized conserved protein [Function unknown]; Region: COG3375 446470010111 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446470010112 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 446470010113 metal binding site [ion binding]; metal-binding site 446470010114 substrate binding pocket [chemical binding]; other site 446470010115 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446470010116 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 446470010117 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 446470010118 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 446470010119 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446470010120 dimerization interface [polypeptide binding]; other site 446470010121 DPS ferroxidase diiron center [ion binding]; other site 446470010122 ion pore; other site 446470010123 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 446470010124 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 446470010125 Clp amino terminal domain; Region: Clp_N; pfam02861 446470010126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470010127 Walker A motif; other site 446470010128 ATP binding site [chemical binding]; other site 446470010129 Walker B motif; other site 446470010130 arginine finger; other site 446470010131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470010132 Walker A motif; other site 446470010133 ATP binding site [chemical binding]; other site 446470010134 Walker B motif; other site 446470010135 arginine finger; other site 446470010136 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446470010137 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470010138 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446470010139 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446470010140 oligomer interface [polypeptide binding]; other site 446470010141 metal binding site [ion binding]; metal-binding site 446470010142 metal binding site [ion binding]; metal-binding site 446470010143 putative Cl binding site [ion binding]; other site 446470010144 basic sphincter; other site 446470010145 hydrophobic gate; other site 446470010146 periplasmic entrance; other site 446470010147 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 446470010148 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 446470010149 TrkA-C domain; Region: TrkA_C; pfam02080 446470010150 TrkA-C domain; Region: TrkA_C; pfam02080 446470010151 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 446470010152 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 446470010153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470010154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470010155 homodimer interface [polypeptide binding]; other site 446470010156 catalytic residue [active] 446470010157 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 446470010158 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 446470010159 TrkA-C domain; Region: TrkA_C; pfam02080 446470010160 TrkA-C domain; Region: TrkA_C; pfam02080 446470010161 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 446470010162 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446470010163 FtsX-like permease family; Region: FtsX; pfam02687 446470010164 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470010165 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470010166 Walker A/P-loop; other site 446470010167 ATP binding site [chemical binding]; other site 446470010168 Q-loop/lid; other site 446470010169 ABC transporter signature motif; other site 446470010170 Walker B; other site 446470010171 D-loop; other site 446470010172 H-loop/switch region; other site 446470010173 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470010174 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470010175 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446470010176 CoenzymeA binding site [chemical binding]; other site 446470010177 subunit interaction site [polypeptide binding]; other site 446470010178 PHB binding site; other site 446470010179 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446470010180 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446470010181 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 446470010182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470010183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470010184 DNA binding residues [nucleotide binding] 446470010185 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 446470010186 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 446470010187 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 446470010188 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 446470010189 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 446470010190 ligand binding site [chemical binding]; other site 446470010191 homodimer interface [polypeptide binding]; other site 446470010192 NAD(P) binding site [chemical binding]; other site 446470010193 trimer interface B [polypeptide binding]; other site 446470010194 trimer interface A [polypeptide binding]; other site 446470010195 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470010196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470010197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470010198 DNA binding residues [nucleotide binding] 446470010199 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470010200 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470010201 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470010202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470010203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470010204 DNA binding residues [nucleotide binding] 446470010205 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470010206 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470010207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010208 Walker A/P-loop; other site 446470010209 ATP binding site [chemical binding]; other site 446470010210 Q-loop/lid; other site 446470010211 ABC transporter signature motif; other site 446470010212 Walker B; other site 446470010213 D-loop; other site 446470010214 H-loop/switch region; other site 446470010215 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446470010216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470010217 substrate binding site [chemical binding]; other site 446470010218 oxyanion hole (OAH) forming residues; other site 446470010219 trimer interface [polypeptide binding]; other site 446470010220 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470010221 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470010222 AAA ATPase domain; Region: AAA_16; pfam13191 446470010223 NB-ARC domain; Region: NB-ARC; pfam00931 446470010224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010225 TPR repeat; Region: TPR_11; pfam13414 446470010226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010227 binding surface 446470010228 TPR motif; other site 446470010229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010231 binding surface 446470010232 TPR motif; other site 446470010233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010234 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446470010235 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446470010236 FAD binding pocket [chemical binding]; other site 446470010237 FAD binding motif [chemical binding]; other site 446470010238 phosphate binding motif [ion binding]; other site 446470010239 NAD binding pocket [chemical binding]; other site 446470010240 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470010241 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470010242 ABC-ATPase subunit interface; other site 446470010243 dimer interface [polypeptide binding]; other site 446470010244 putative PBP binding regions; other site 446470010245 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470010246 ABC-ATPase subunit interface; other site 446470010247 dimer interface [polypeptide binding]; other site 446470010248 putative PBP binding regions; other site 446470010249 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446470010250 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446470010251 siderophore binding site; other site 446470010252 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470010253 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470010254 Walker A/P-loop; other site 446470010255 ATP binding site [chemical binding]; other site 446470010256 Q-loop/lid; other site 446470010257 ABC transporter signature motif; other site 446470010258 Walker B; other site 446470010259 D-loop; other site 446470010260 H-loop/switch region; other site 446470010261 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 446470010262 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446470010263 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470010264 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470010265 NB-ARC domain; Region: NB-ARC; pfam00931 446470010266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010268 binding surface 446470010269 TPR motif; other site 446470010270 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 446470010271 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446470010272 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446470010273 shikimate binding site; other site 446470010274 NAD(P) binding site [chemical binding]; other site 446470010275 YceG-like family; Region: YceG; pfam02618 446470010276 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 446470010277 dimerization interface [polypeptide binding]; other site 446470010278 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 446470010279 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446470010280 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 446470010281 motif 1; other site 446470010282 active site 446470010283 motif 2; other site 446470010284 motif 3; other site 446470010285 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 446470010286 recombination factor protein RarA; Reviewed; Region: PRK13342 446470010287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470010288 Walker A motif; other site 446470010289 ATP binding site [chemical binding]; other site 446470010290 Walker B motif; other site 446470010291 arginine finger; other site 446470010292 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 446470010293 DNA binding site [nucleotide binding] 446470010294 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470010295 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470010296 NB-ARC domain; Region: NB-ARC; pfam00931 446470010297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010298 TPR motif; other site 446470010299 binding surface 446470010300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010302 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446470010303 active site 446470010304 catalytic residues [active] 446470010305 metal binding site [ion binding]; metal-binding site 446470010306 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446470010307 active site 446470010308 intersubunit interface [polypeptide binding]; other site 446470010309 catalytic residue [active] 446470010310 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470010311 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446470010312 substrate binding site [chemical binding]; other site 446470010313 ATP binding site [chemical binding]; other site 446470010314 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 446470010315 NmrA-like family; Region: NmrA; pfam05368 446470010316 NADP binding site [chemical binding]; other site 446470010317 active site 446470010318 regulatory binding site [polypeptide binding]; other site 446470010319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470010320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010321 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 446470010322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470010323 substrate binding site [chemical binding]; other site 446470010324 oxyanion hole (OAH) forming residues; other site 446470010325 trimer interface [polypeptide binding]; other site 446470010326 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446470010327 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470010328 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470010329 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 446470010330 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446470010331 dimer interface [polypeptide binding]; other site 446470010332 active site 446470010333 hypothetical protein; Provisional; Region: PRK07236 446470010334 hypothetical protein; Provisional; Region: PRK07588 446470010335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470010336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010337 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470010338 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 446470010339 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470010340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470010341 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446470010342 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446470010343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470010344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470010345 active site 446470010346 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446470010347 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446470010348 active site 446470010349 HIGH motif; other site 446470010350 dimer interface [polypeptide binding]; other site 446470010351 KMSKS motif; other site 446470010352 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446470010353 Sulfatase; Region: Sulfatase; pfam00884 446470010354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470010355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470010356 dimer interface [polypeptide binding]; other site 446470010357 phosphorylation site [posttranslational modification] 446470010358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470010359 ATP binding site [chemical binding]; other site 446470010360 Mg2+ binding site [ion binding]; other site 446470010361 G-X-G motif; other site 446470010362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470010363 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 446470010364 active site 446470010365 phosphorylation site [posttranslational modification] 446470010366 intermolecular recognition site; other site 446470010367 dimerization interface [polypeptide binding]; other site 446470010368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470010369 DNA binding site [nucleotide binding] 446470010370 MFS transport protein AraJ; Provisional; Region: PRK10091 446470010371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470010372 putative substrate translocation pore; other site 446470010373 MarR family; Region: MarR; pfam01047 446470010374 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446470010375 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 446470010376 SelR domain; Region: SelR; pfam01641 446470010377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470010378 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470010379 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 446470010380 trimer interface [polypeptide binding]; other site 446470010381 active site 446470010382 G bulge; other site 446470010383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470010384 Coenzyme A binding pocket [chemical binding]; other site 446470010385 amino acid transporter; Region: 2A0306; TIGR00909 446470010386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010387 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 446470010388 active site 446470010389 oxyanion hole [active] 446470010390 catalytic triad [active] 446470010391 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470010392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470010393 S-adenosylmethionine binding site [chemical binding]; other site 446470010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470010395 putative substrate translocation pore; other site 446470010396 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470010397 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470010398 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470010399 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 446470010400 NADP binding site [chemical binding]; other site 446470010401 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446470010402 Protein of unknown function DUF58; Region: DUF58; pfam01882 446470010403 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 446470010404 MoxR-like ATPases [General function prediction only]; Region: COG0714 446470010405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470010406 Walker A motif; other site 446470010407 ATP binding site [chemical binding]; other site 446470010408 Walker B motif; other site 446470010409 arginine finger; other site 446470010410 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 446470010411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010412 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470010413 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 446470010414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446470010415 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 446470010416 substrate binding site [chemical binding]; other site 446470010417 active site 446470010418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470010419 S-adenosylmethionine binding site [chemical binding]; other site 446470010420 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 446470010421 putative substrate binding site [chemical binding]; other site 446470010422 active site 446470010423 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 446470010424 Ca binding site [ion binding]; other site 446470010425 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 446470010426 ArsC family; Region: ArsC; pfam03960 446470010427 catalytic residues [active] 446470010428 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470010429 hypothetical protein; Provisional; Region: PRK07236 446470010430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470010431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010432 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446470010433 homotrimer interaction site [polypeptide binding]; other site 446470010434 putative active site [active] 446470010435 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446470010436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470010437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470010438 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470010439 putative dimerization interface [polypeptide binding]; other site 446470010440 Domain of unknown function DUF11; Region: DUF11; pfam01345 446470010441 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 446470010442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470010443 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446470010444 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 446470010445 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446470010446 putative active site [active] 446470010447 catalytic triad [active] 446470010448 putative dimer interface [polypeptide binding]; other site 446470010449 MutL protein; Region: MutL; pfam13941 446470010450 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446470010451 active site 2 [active] 446470010452 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446470010453 B12 binding site [chemical binding]; other site 446470010454 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 446470010455 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446470010456 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470010457 active site 446470010458 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446470010459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 446470010460 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 446470010461 active site 446470010462 catalytic residues [active] 446470010463 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470010464 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470010465 DoxX-like family; Region: DoxX_2; pfam13564 446470010466 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470010467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470010468 putative DNA binding site [nucleotide binding]; other site 446470010469 putative Zn2+ binding site [ion binding]; other site 446470010470 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 446470010471 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 446470010472 glutaminase; Provisional; Region: PRK00971 446470010473 AIPR protein; Region: AIPR; pfam10592 446470010474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 446470010475 active site 446470010476 Domain of unknown function DUF87; Region: DUF87; pfam01935 446470010477 AAA-like domain; Region: AAA_10; pfam12846 446470010478 Zonular occludens toxin (Zot); Region: Zot; cl17485 446470010479 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470010480 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470010481 RibD C-terminal domain; Region: RibD_C; cl17279 446470010482 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470010483 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470010484 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470010485 nudix motif; other site 446470010486 nudix motif; other site 446470010487 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 446470010488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470010489 ATP binding site [chemical binding]; other site 446470010490 putative Mg++ binding site [ion binding]; other site 446470010491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 446470010492 nucleotide binding region [chemical binding]; other site 446470010493 ATP-binding site [chemical binding]; other site 446470010494 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 446470010495 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 446470010496 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 446470010497 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470010498 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470010499 AAA ATPase domain; Region: AAA_16; pfam13191 446470010500 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 446470010501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010502 binding surface 446470010503 TPR motif; other site 446470010504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010505 TPR motif; other site 446470010506 binding surface 446470010507 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470010508 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470010509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010510 Walker A/P-loop; other site 446470010511 ATP binding site [chemical binding]; other site 446470010512 Q-loop/lid; other site 446470010513 ABC transporter signature motif; other site 446470010514 Walker B; other site 446470010515 D-loop; other site 446470010516 H-loop/switch region; other site 446470010517 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470010518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470010519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010520 Walker A/P-loop; other site 446470010521 ATP binding site [chemical binding]; other site 446470010522 Q-loop/lid; other site 446470010523 ABC transporter signature motif; other site 446470010524 Walker B; other site 446470010525 D-loop; other site 446470010526 H-loop/switch region; other site 446470010527 TIGR03085 family protein; Region: TIGR03085 446470010528 RNA polymerase I-specific transcription-initiation factor; Region: Rrn6; pfam10214 446470010529 chaperone protein DnaJ; Provisional; Region: PRK14281 446470010530 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 446470010531 Active_site [active] 446470010532 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446470010533 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446470010534 Walker A/P-loop; other site 446470010535 ATP binding site [chemical binding]; other site 446470010536 Q-loop/lid; other site 446470010537 ABC transporter signature motif; other site 446470010538 Walker B; other site 446470010539 D-loop; other site 446470010540 H-loop/switch region; other site 446470010541 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 446470010542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446470010543 substrate binding pocket [chemical binding]; other site 446470010544 membrane-bound complex binding site; other site 446470010545 hinge residues; other site 446470010546 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446470010547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470010548 dimer interface [polypeptide binding]; other site 446470010549 conserved gate region; other site 446470010550 putative PBP binding loops; other site 446470010551 ABC-ATPase subunit interface; other site 446470010552 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446470010553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470010554 dimer interface [polypeptide binding]; other site 446470010555 conserved gate region; other site 446470010556 putative PBP binding loops; other site 446470010557 ABC-ATPase subunit interface; other site 446470010558 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446470010559 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 446470010560 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446470010561 substrate binding site [chemical binding]; other site 446470010562 glutamase interaction surface [polypeptide binding]; other site 446470010563 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470010564 DNA binding site [nucleotide binding] 446470010565 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470010566 NB-ARC domain; Region: NB-ARC; pfam00931 446470010567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010569 binding surface 446470010570 TPR motif; other site 446470010571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010572 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 446470010573 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 446470010574 homotrimer interaction site [polypeptide binding]; other site 446470010575 putative active site [active] 446470010576 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 446470010577 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446470010578 catalytic residues [active] 446470010579 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446470010580 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446470010581 putative active site [active] 446470010582 oxyanion strand; other site 446470010583 catalytic triad [active] 446470010584 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 446470010585 putative active site pocket [active] 446470010586 4-fold oligomerization interface [polypeptide binding]; other site 446470010587 metal binding residues [ion binding]; metal-binding site 446470010588 3-fold/trimer interface [polypeptide binding]; other site 446470010589 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 446470010590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470010591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470010592 homodimer interface [polypeptide binding]; other site 446470010593 catalytic residue [active] 446470010594 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 446470010595 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 446470010596 NAD binding site [chemical binding]; other site 446470010597 dimerization interface [polypeptide binding]; other site 446470010598 product binding site; other site 446470010599 substrate binding site [chemical binding]; other site 446470010600 zinc binding site [ion binding]; other site 446470010601 catalytic residues [active] 446470010602 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 446470010603 AAA domain; Region: AAA_31; pfam13614 446470010604 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 446470010605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446470010606 RNA binding surface [nucleotide binding]; other site 446470010607 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446470010608 active site 446470010609 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 446470010610 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 446470010611 DivIVA protein; Region: DivIVA; pfam05103 446470010612 DivIVA domain; Region: DivI1A_domain; TIGR03544 446470010613 Protein of unknown function (DUF552); Region: DUF552; cl00775 446470010614 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 446470010615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446470010616 catalytic residue [active] 446470010617 cell division protein FtsZ; Validated; Region: PRK09330 446470010618 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 446470010619 nucleotide binding site [chemical binding]; other site 446470010620 SulA interaction site; other site 446470010621 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 446470010622 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 446470010623 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446470010624 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446470010625 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470010626 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470010627 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446470010628 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446470010629 active site 446470010630 homodimer interface [polypeptide binding]; other site 446470010631 cell division protein FtsW; Region: ftsW; TIGR02614 446470010632 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 446470010633 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470010634 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470010635 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 446470010636 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446470010637 Mg++ binding site [ion binding]; other site 446470010638 putative catalytic motif [active] 446470010639 putative substrate binding site [chemical binding]; other site 446470010640 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446470010641 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470010642 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470010643 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446470010644 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446470010645 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470010646 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470010647 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470010648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470010650 binding surface 446470010651 TPR motif; other site 446470010652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470010653 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 446470010654 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 446470010655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446470010656 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446470010657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470010658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470010659 dimerization interface [polypeptide binding]; other site 446470010660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470010661 dimer interface [polypeptide binding]; other site 446470010662 phosphorylation site [posttranslational modification] 446470010663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446470010664 ATP binding site [chemical binding]; other site 446470010665 Mg2+ binding site [ion binding]; other site 446470010666 G-X-G motif; other site 446470010667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470010668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470010669 active site 446470010670 phosphorylation site [posttranslational modification] 446470010671 intermolecular recognition site; other site 446470010672 dimerization interface [polypeptide binding]; other site 446470010673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470010674 DNA binding site [nucleotide binding] 446470010675 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446470010676 Glucitol operon activator protein (GutM); Region: GutM; cl01890 446470010677 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446470010678 hypothetical protein; Provisional; Region: PRK14059 446470010679 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446470010680 HerA helicase [Replication, recombination, and repair]; Region: COG0433 446470010681 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 446470010682 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446470010683 active site 446470010684 metal binding site [ion binding]; metal-binding site 446470010685 DNA binding site [nucleotide binding] 446470010686 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 446470010687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010688 AAA domain; Region: AAA_23; pfam13476 446470010689 Walker A/P-loop; other site 446470010690 ATP binding site [chemical binding]; other site 446470010691 Q-loop/lid; other site 446470010692 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446470010693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010694 ABC transporter signature motif; other site 446470010695 Walker B; other site 446470010696 D-loop; other site 446470010697 H-loop/switch region; other site 446470010698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 446470010699 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 446470010700 Homeodomain-like domain; Region: HTH_23; cl17451 446470010701 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446470010702 Sulfatase; Region: Sulfatase; pfam00884 446470010703 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470010704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470010705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010706 Walker A/P-loop; other site 446470010707 ATP binding site [chemical binding]; other site 446470010708 Q-loop/lid; other site 446470010709 ABC transporter signature motif; other site 446470010710 Walker B; other site 446470010711 D-loop; other site 446470010712 H-loop/switch region; other site 446470010713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446470010714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470010715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470010716 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446470010717 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 446470010718 conserved cys residue [active] 446470010719 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470010720 MarR family; Region: MarR_2; pfam12802 446470010721 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446470010722 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 446470010723 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446470010724 DNA binding residues [nucleotide binding] 446470010725 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470010726 drug binding residues [chemical binding]; other site 446470010727 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 446470010728 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 446470010729 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470010730 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470010731 conserved cys residue [active] 446470010732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470010733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470010734 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 446470010735 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446470010736 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446470010737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470010738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010739 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470010740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470010741 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470010742 NAD(P) binding site [chemical binding]; other site 446470010743 active site 446470010744 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 446470010745 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 446470010746 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446470010747 putative active site [active] 446470010748 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446470010749 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446470010750 acyl-activating enzyme (AAE) consensus motif; other site 446470010751 AMP binding site [chemical binding]; other site 446470010752 Condensation domain; Region: Condensation; pfam00668 446470010753 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446470010754 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446470010755 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446470010756 acyl-activating enzyme (AAE) consensus motif; other site 446470010757 AMP binding site [chemical binding]; other site 446470010758 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470010759 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470010760 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 446470010761 active site 446470010762 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446470010763 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470010764 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470010765 MbtH-like protein; Region: MbtH; cl01279 446470010766 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446470010767 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470010768 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446470010769 active site 446470010770 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 446470010771 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470010772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470010773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010774 Walker A/P-loop; other site 446470010775 ATP binding site [chemical binding]; other site 446470010776 Q-loop/lid; other site 446470010777 ABC transporter signature motif; other site 446470010778 Walker B; other site 446470010779 D-loop; other site 446470010780 H-loop/switch region; other site 446470010781 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470010782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470010783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010784 Walker A/P-loop; other site 446470010785 ATP binding site [chemical binding]; other site 446470010786 Q-loop/lid; other site 446470010787 ABC transporter signature motif; other site 446470010788 Walker B; other site 446470010789 D-loop; other site 446470010790 H-loop/switch region; other site 446470010791 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 446470010792 active site clefts [active] 446470010793 zinc binding site [ion binding]; other site 446470010794 dimer interface [polypeptide binding]; other site 446470010795 hypothetical protein; Provisional; Region: PRK07236 446470010796 hypothetical protein; Provisional; Region: PRK07588 446470010797 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 446470010798 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 446470010799 putative active site [active] 446470010800 MgATP binding site [chemical binding]; other site 446470010801 N- and C-terminal domain interface [polypeptide binding]; other site 446470010802 putative xylulose binding site [chemical binding]; other site 446470010803 putative homodimer interface [polypeptide binding]; other site 446470010804 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446470010805 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446470010806 intersubunit interface [polypeptide binding]; other site 446470010807 active site 446470010808 Zn2+ binding site [ion binding]; other site 446470010809 Uncharacterized conserved protein [Function unknown]; Region: COG3347 446470010810 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 446470010811 active site 446470010812 Zn2+ binding site [ion binding]; other site 446470010813 intersubunit interface [polypeptide binding]; other site 446470010814 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 446470010815 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 446470010816 putative N- and C-terminal domain interface [polypeptide binding]; other site 446470010817 putative active site [active] 446470010818 MgATP binding site [chemical binding]; other site 446470010819 catalytic site [active] 446470010820 metal binding site [ion binding]; metal-binding site 446470010821 putative xylulose binding site [chemical binding]; other site 446470010822 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 446470010823 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446470010824 putative ligand binding site [chemical binding]; other site 446470010825 putative NAD binding site [chemical binding]; other site 446470010826 catalytic site [active] 446470010827 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 446470010828 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 446470010829 Walker A/P-loop; other site 446470010830 ATP binding site [chemical binding]; other site 446470010831 Q-loop/lid; other site 446470010832 ABC transporter signature motif; other site 446470010833 Walker B; other site 446470010834 D-loop; other site 446470010835 H-loop/switch region; other site 446470010836 TOBE domain; Region: TOBE_2; pfam08402 446470010837 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 446470010838 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446470010839 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 446470010840 DAK2 domain; Region: Dak2; pfam02734 446470010841 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 446470010842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470010843 motif II; other site 446470010844 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446470010845 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446470010846 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446470010847 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 446470010848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470010849 Walker A/P-loop; other site 446470010850 ATP binding site [chemical binding]; other site 446470010851 Q-loop/lid; other site 446470010852 ABC transporter signature motif; other site 446470010853 Walker B; other site 446470010854 D-loop; other site 446470010855 H-loop/switch region; other site 446470010856 TOBE domain; Region: TOBE_2; pfam08402 446470010857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470010858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470010859 dimer interface [polypeptide binding]; other site 446470010860 conserved gate region; other site 446470010861 putative PBP binding loops; other site 446470010862 ABC-ATPase subunit interface; other site 446470010863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470010864 dimer interface [polypeptide binding]; other site 446470010865 conserved gate region; other site 446470010866 putative PBP binding loops; other site 446470010867 ABC-ATPase subunit interface; other site 446470010868 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470010869 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470010870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446470010871 catalytic core [active] 446470010872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470010873 D-xylulose kinase; Region: XylB; TIGR01312 446470010874 nucleotide binding site [chemical binding]; other site 446470010875 short chain dehydrogenase; Provisional; Region: PRK06523 446470010876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470010877 NAD(P) binding site [chemical binding]; other site 446470010878 active site 446470010879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470010880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470010881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470010882 Coenzyme A binding pocket [chemical binding]; other site 446470010883 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470010884 adenosine deaminase; Provisional; Region: PRK09358 446470010885 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446470010886 active site 446470010887 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446470010888 active site 446470010889 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470010890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470010891 non-specific DNA binding site [nucleotide binding]; other site 446470010892 salt bridge; other site 446470010893 sequence-specific DNA binding site [nucleotide binding]; other site 446470010894 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 446470010895 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 446470010896 putative active site [active] 446470010897 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 446470010898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446470010899 putative DNA binding site [nucleotide binding]; other site 446470010900 putative Zn2+ binding site [ion binding]; other site 446470010901 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446470010902 putative hydrophobic ligand binding site [chemical binding]; other site 446470010903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470010904 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470010905 Coenzyme A binding pocket [chemical binding]; other site 446470010906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470010907 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 446470010908 Phosphotransferase enzyme family; Region: APH; pfam01636 446470010909 active site 446470010910 ATP binding site [chemical binding]; other site 446470010911 antibiotic binding site [chemical binding]; other site 446470010912 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 446470010913 adenosine deaminase; Provisional; Region: PRK09358 446470010914 active site 446470010915 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446470010916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470010917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470010918 DNA binding residues [nucleotide binding] 446470010919 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446470010920 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 446470010921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470010922 non-specific DNA binding site [nucleotide binding]; other site 446470010923 salt bridge; other site 446470010924 sequence-specific DNA binding site [nucleotide binding]; other site 446470010925 Cupin domain; Region: Cupin_2; pfam07883 446470010926 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446470010927 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 446470010928 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 446470010929 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446470010930 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446470010931 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446470010932 inhibitor site; inhibition site 446470010933 active site 446470010934 dimer interface [polypeptide binding]; other site 446470010935 catalytic residue [active] 446470010936 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 446470010937 Proline racemase; Region: Pro_racemase; pfam05544 446470010938 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446470010939 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446470010940 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446470010941 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 446470010942 dimer interface [polypeptide binding]; other site 446470010943 NADP binding site [chemical binding]; other site 446470010944 catalytic residues [active] 446470010945 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446470010946 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 446470010947 active site 446470010948 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 446470010949 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446470010950 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 446470010951 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446470010952 interchain domain interface [polypeptide binding]; other site 446470010953 intrachain domain interface; other site 446470010954 heme bL binding site [chemical binding]; other site 446470010955 heme bH binding site [chemical binding]; other site 446470010956 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 446470010957 Qo binding site; other site 446470010958 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446470010959 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446470010960 iron-sulfur cluster [ion binding]; other site 446470010961 [2Fe-2S] cluster binding site [ion binding]; other site 446470010962 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 446470010963 Cytochrome c; Region: Cytochrom_C; pfam00034 446470010964 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 446470010965 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446470010966 Subunit I/III interface [polypeptide binding]; other site 446470010967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470010968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446470010969 active site 446470010970 phosphorylation site [posttranslational modification] 446470010971 intermolecular recognition site; other site 446470010972 dimerization interface [polypeptide binding]; other site 446470010973 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446470010974 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446470010975 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446470010976 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470010977 nudix motif; other site 446470010978 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470010979 AsnC family; Region: AsnC_trans_reg; pfam01037 446470010980 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 446470010981 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446470010982 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 446470010983 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 446470010984 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 446470010985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470010986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470010987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470010988 Nitrate and nitrite sensing; Region: NIT; pfam08376 446470010989 sensory histidine kinase CreC; Provisional; Region: PRK11100 446470010990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470010991 ATP binding site [chemical binding]; other site 446470010992 Mg2+ binding site [ion binding]; other site 446470010993 G-X-G motif; other site 446470010994 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 446470010995 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446470010996 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470010997 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446470010998 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446470010999 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470011000 active site 446470011001 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470011002 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446470011003 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446470011004 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446470011005 putative NADP binding site [chemical binding]; other site 446470011006 active site 446470011007 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446470011008 Erythronolide synthase docking; Region: Docking; pfam08990 446470011009 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470011010 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446470011011 active site 446470011012 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446470011013 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470011014 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446470011015 Thioesterase; Region: PKS_TE; smart00824 446470011016 Erythronolide synthase docking; Region: Docking; pfam08990 446470011017 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470011018 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446470011019 active site 446470011020 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446470011021 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470011022 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446470011023 Erythronolide synthase docking; Region: Docking; pfam08990 446470011024 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446470011025 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446470011026 active site 446470011027 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446470011028 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446470011029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011030 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446470011031 Enoylreductase; Region: PKS_ER; smart00829 446470011032 NAD(P) binding site [chemical binding]; other site 446470011033 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446470011034 putative NADP binding site [chemical binding]; other site 446470011035 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446470011036 active site 446470011037 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446470011038 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446470011039 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470011040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470011041 S-adenosylmethionine binding site [chemical binding]; other site 446470011042 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446470011043 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 446470011044 NAD(P) binding site [chemical binding]; other site 446470011045 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470011046 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470011047 NB-ARC domain; Region: NB-ARC; pfam00931 446470011048 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 446470011049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470011050 TPR motif; other site 446470011051 binding surface 446470011052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470011053 TPR motif; other site 446470011054 binding surface 446470011055 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446470011056 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470011057 Walker A/P-loop; other site 446470011058 ATP binding site [chemical binding]; other site 446470011059 Q-loop/lid; other site 446470011060 ABC transporter signature motif; other site 446470011061 Walker B; other site 446470011062 D-loop; other site 446470011063 H-loop/switch region; other site 446470011064 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470011065 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470011066 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470011067 Walker A/P-loop; other site 446470011068 ATP binding site [chemical binding]; other site 446470011069 Q-loop/lid; other site 446470011070 ABC transporter signature motif; other site 446470011071 Walker B; other site 446470011072 D-loop; other site 446470011073 H-loop/switch region; other site 446470011074 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446470011075 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446470011076 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446470011077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470011078 dimer interface [polypeptide binding]; other site 446470011079 conserved gate region; other site 446470011080 putative PBP binding loops; other site 446470011081 ABC-ATPase subunit interface; other site 446470011082 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 446470011083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470011084 dimer interface [polypeptide binding]; other site 446470011085 conserved gate region; other site 446470011086 putative PBP binding loops; other site 446470011087 ABC-ATPase subunit interface; other site 446470011088 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446470011089 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 446470011090 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 446470011091 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470011092 substrate binding site [chemical binding]; other site 446470011093 ATP binding site [chemical binding]; other site 446470011094 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 446470011095 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446470011096 quinolinate synthetase; Provisional; Region: PRK09375 446470011097 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446470011098 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446470011099 hinge; other site 446470011100 active site 446470011101 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446470011102 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 446470011103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470011104 Walker A/P-loop; other site 446470011105 ATP binding site [chemical binding]; other site 446470011106 Q-loop/lid; other site 446470011107 ABC transporter signature motif; other site 446470011108 Walker B; other site 446470011109 D-loop; other site 446470011110 H-loop/switch region; other site 446470011111 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446470011112 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446470011113 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446470011114 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470011115 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470011116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470011117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470011118 active site 446470011119 catalytic tetrad [active] 446470011120 CBD_II domain; Region: CBD_II; smart00637 446470011121 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446470011122 Interdomain contacts; other site 446470011123 Cytokine receptor motif; other site 446470011124 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446470011125 Glyco_18 domain; Region: Glyco_18; smart00636 446470011126 active site 446470011127 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 446470011128 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 446470011129 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446470011130 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446470011131 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446470011132 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 446470011133 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 446470011134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446470011135 PAS domain; Region: PAS_9; pfam13426 446470011136 putative active site [active] 446470011137 heme pocket [chemical binding]; other site 446470011138 PAS fold; Region: PAS_4; pfam08448 446470011139 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446470011140 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446470011141 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446470011142 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 446470011143 active site 446470011144 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470011145 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470011146 AAA ATPase domain; Region: AAA_16; pfam13191 446470011147 Predicted ATPase [General function prediction only]; Region: COG3903 446470011148 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446470011149 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446470011150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470011151 FeS/SAM binding site; other site 446470011152 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446470011153 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446470011154 DNA-binding site [nucleotide binding]; DNA binding site 446470011155 RNA-binding motif; other site 446470011156 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470011157 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446470011158 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446470011159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470011160 DNA-binding site [nucleotide binding]; DNA binding site 446470011161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470011162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470011163 homodimer interface [polypeptide binding]; other site 446470011164 catalytic residue [active] 446470011165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470011166 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470011167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470011168 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446470011169 Cation efflux family; Region: Cation_efflux; pfam01545 446470011170 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 446470011171 recombination regulator RecX; Reviewed; Region: recX; PRK00117 446470011172 recombinase A; Provisional; Region: recA; PRK09354 446470011173 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446470011174 hexamer interface [polypeptide binding]; other site 446470011175 Walker A motif; other site 446470011176 ATP binding site [chemical binding]; other site 446470011177 Walker B motif; other site 446470011178 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446470011179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470011180 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 446470011181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470011182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470011183 homodimer interface [polypeptide binding]; other site 446470011184 catalytic residue [active] 446470011185 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446470011186 leucine export protein LeuE; Provisional; Region: PRK10958 446470011187 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446470011188 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470011189 putative catalytic site [active] 446470011190 putative metal binding site [ion binding]; other site 446470011191 putative phosphate binding site [ion binding]; other site 446470011192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470011193 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446470011194 ATP binding site [chemical binding]; other site 446470011195 putative Mg++ binding site [ion binding]; other site 446470011196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470011197 nucleotide binding region [chemical binding]; other site 446470011198 ATP-binding site [chemical binding]; other site 446470011199 DEAD/H associated; Region: DEAD_assoc; pfam08494 446470011200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470011201 S-adenosylmethionine binding site [chemical binding]; other site 446470011202 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 446470011203 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 446470011204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470011205 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446470011206 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 446470011207 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446470011208 E3 interaction surface; other site 446470011209 lipoyl attachment site [posttranslational modification]; other site 446470011210 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446470011211 E3 interaction surface; other site 446470011212 lipoyl attachment site [posttranslational modification]; other site 446470011213 e3 binding domain; Region: E3_binding; pfam02817 446470011214 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446470011215 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446470011216 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446470011217 oligomer interface [polypeptide binding]; other site 446470011218 metal binding site [ion binding]; metal-binding site 446470011219 metal binding site [ion binding]; metal-binding site 446470011220 putative Cl binding site [ion binding]; other site 446470011221 basic sphincter; other site 446470011222 hydrophobic gate; other site 446470011223 periplasmic entrance; other site 446470011224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011225 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 446470011226 NAD(P) binding site [chemical binding]; other site 446470011227 active site 446470011228 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446470011229 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446470011230 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470011231 TIGR03086 family protein; Region: TIGR03086 446470011232 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446470011233 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 446470011234 catalytic residues [active] 446470011235 catalytic nucleophile [active] 446470011236 Recombinase; Region: Recombinase; pfam07508 446470011237 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 446470011238 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446470011239 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 446470011240 DNA-binding residues [nucleotide binding]; DNA binding site 446470011241 nucleotide binding site [chemical binding]; other site 446470011242 polymerase nucleotide-binding site; other site 446470011243 primase nucleotide-binding site [nucleotide binding]; other site 446470011244 AAA domain; Region: AAA_25; pfam13481 446470011245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470011246 Walker A/P-loop; other site 446470011247 ATP binding site [chemical binding]; other site 446470011248 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446470011249 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446470011250 cofactor binding site; other site 446470011251 DNA binding site [nucleotide binding] 446470011252 substrate interaction site [chemical binding]; other site 446470011253 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446470011254 active site 446470011255 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446470011256 Ligand Binding Site [chemical binding]; other site 446470011257 Protein of unknown function (DUF422); Region: DUF422; cl00991 446470011258 Phage Terminase; Region: Terminase_1; pfam03354 446470011259 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446470011260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470011261 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 446470011262 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 446470011263 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446470011264 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 446470011265 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446470011266 Ligand Binding Site [chemical binding]; other site 446470011267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470011268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470011269 non-specific DNA binding site [nucleotide binding]; other site 446470011270 salt bridge; other site 446470011271 sequence-specific DNA binding site [nucleotide binding]; other site 446470011272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470011273 non-specific DNA binding site [nucleotide binding]; other site 446470011274 salt bridge; other site 446470011275 sequence-specific DNA binding site [nucleotide binding]; other site 446470011276 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470011277 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470011278 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470011279 active site 446470011280 metal binding site [ion binding]; metal-binding site 446470011281 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 446470011282 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 446470011283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470011284 sequence-specific DNA binding site [nucleotide binding]; other site 446470011285 salt bridge; other site 446470011286 Competence-damaged protein; Region: CinA; pfam02464 446470011287 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446470011288 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446470011289 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 446470011290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470011291 FeS/SAM binding site; other site 446470011292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446470011293 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 446470011294 NADP binding site [chemical binding]; other site 446470011295 homodimer interface [polypeptide binding]; other site 446470011296 active site 446470011297 substrate binding site [chemical binding]; other site 446470011298 Electron transfer DM13; Region: DM13; pfam10517 446470011299 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446470011300 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 446470011301 conserved cys residue [active] 446470011302 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470011303 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470011304 Coenzyme A binding pocket [chemical binding]; other site 446470011305 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470011306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011307 NAD(P) binding site [chemical binding]; other site 446470011308 active site 446470011309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470011310 Coenzyme A binding pocket [chemical binding]; other site 446470011311 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 446470011312 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446470011313 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446470011314 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 446470011315 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446470011316 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 446470011317 putative active site [active] 446470011318 putative metal binding site [ion binding]; other site 446470011319 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446470011320 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 446470011321 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446470011322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470011323 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446470011324 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446470011325 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446470011326 dimer interface [polypeptide binding]; other site 446470011327 active site 446470011328 catalytic residue [active] 446470011329 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 446470011330 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446470011331 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446470011332 DNA binding site [nucleotide binding] 446470011333 active site 446470011334 Protease prsW family; Region: PrsW-protease; pfam13367 446470011335 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446470011336 beta-galactosidase; Region: BGL; TIGR03356 446470011337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470011338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470011339 putative substrate translocation pore; other site 446470011340 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470011341 active site 446470011342 metal binding site [ion binding]; metal-binding site 446470011343 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470011344 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 446470011345 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470011346 active site 446470011347 metal binding site [ion binding]; metal-binding site 446470011348 translocation protein TolB; Provisional; Region: tolB; PRK02889 446470011349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470011350 S-adenosylmethionine binding site [chemical binding]; other site 446470011351 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446470011352 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 446470011353 homodimer interface [polypeptide binding]; other site 446470011354 substrate-cofactor binding pocket; other site 446470011355 catalytic residue [active] 446470011356 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 446470011357 tartrate dehydrogenase; Region: TTC; TIGR02089 446470011358 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470011359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470011360 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470011361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470011362 S-adenosylmethionine binding site [chemical binding]; other site 446470011363 ubiquinone biosynthesis methyltransferase; Region: PLN02232 446470011364 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446470011365 active site 446470011366 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 446470011367 AAA domain; Region: AAA_18; pfam13238 446470011368 P-loop motif; other site 446470011369 ATP binding site [chemical binding]; other site 446470011370 Chloramphenicol (Cm) binding site [chemical binding]; other site 446470011371 catalytic residue [active] 446470011372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470011373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470011374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470011375 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470011376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470011377 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470011378 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470011379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011380 NAD(P) binding site [chemical binding]; other site 446470011381 active site 446470011382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470011383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470011384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470011385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470011386 Walker A/P-loop; other site 446470011387 ATP binding site [chemical binding]; other site 446470011388 Q-loop/lid; other site 446470011389 ABC transporter signature motif; other site 446470011390 Walker B; other site 446470011391 D-loop; other site 446470011392 H-loop/switch region; other site 446470011393 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446470011394 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446470011395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470011396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470011397 non-specific DNA binding site [nucleotide binding]; other site 446470011398 salt bridge; other site 446470011399 sequence-specific DNA binding site [nucleotide binding]; other site 446470011400 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446470011401 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 446470011402 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446470011403 active site 446470011404 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 446470011405 Chitinase C; Region: ChiC; pfam06483 446470011406 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 446470011407 aromatic chitin/cellulose binding site residues [chemical binding]; other site 446470011408 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 446470011409 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446470011410 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 446470011411 putative dimer interface [polypeptide binding]; other site 446470011412 N-terminal domain interface [polypeptide binding]; other site 446470011413 putative substrate binding pocket (H-site) [chemical binding]; other site 446470011414 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446470011415 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470011416 calcium binding site 2 [ion binding]; other site 446470011417 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446470011418 active site 446470011419 catalytic triad [active] 446470011420 calcium binding site 1 [ion binding]; other site 446470011421 PPE family; Region: PPE; pfam00823 446470011422 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470011423 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 446470011424 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 446470011425 ligand binding site [chemical binding]; other site 446470011426 NAD binding site [chemical binding]; other site 446470011427 dimerization interface [polypeptide binding]; other site 446470011428 catalytic site [active] 446470011429 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 446470011430 putative L-serine binding site [chemical binding]; other site 446470011431 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470011432 Cytochrome P450; Region: p450; cl12078 446470011433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470011434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470011435 DNA binding residues [nucleotide binding] 446470011436 dimerization interface [polypeptide binding]; other site 446470011437 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470011438 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446470011439 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446470011440 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446470011441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470011442 putative substrate translocation pore; other site 446470011443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470011444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470011445 putative transporter; Provisional; Region: PRK11021 446470011446 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470011447 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446470011448 putative DNA binding site [nucleotide binding]; other site 446470011449 putative Zn2+ binding site [ion binding]; other site 446470011450 AsnC family; Region: AsnC_trans_reg; pfam01037 446470011451 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446470011452 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 446470011453 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446470011454 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470011455 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446470011456 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470011457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470011458 Coenzyme A binding pocket [chemical binding]; other site 446470011459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470011460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470011461 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 446470011462 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470011463 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 446470011464 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470011465 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446470011466 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470011467 conserved cys residue [active] 446470011468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470011469 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446470011470 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446470011471 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 446470011472 putative deacylase active site [active] 446470011473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446470011474 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 446470011475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470011476 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470011477 Asp23 family; Region: Asp23; pfam03780 446470011478 Fic/DOC family; Region: Fic; cl00960 446470011479 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446470011480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470011481 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470011482 active site 446470011483 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446470011484 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 446470011485 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446470011486 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446470011487 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446470011488 putative valine binding site [chemical binding]; other site 446470011489 dimer interface [polypeptide binding]; other site 446470011490 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446470011491 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446470011492 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446470011493 PYR/PP interface [polypeptide binding]; other site 446470011494 dimer interface [polypeptide binding]; other site 446470011495 TPP binding site [chemical binding]; other site 446470011496 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446470011497 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446470011498 TPP-binding site [chemical binding]; other site 446470011499 dimer interface [polypeptide binding]; other site 446470011500 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470011501 PAS fold; Region: PAS_4; pfam08448 446470011502 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470011503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470011504 metal binding site [ion binding]; metal-binding site 446470011505 active site 446470011506 I-site; other site 446470011507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446470011508 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 446470011509 amino acid transporter; Region: 2A0306; TIGR00909 446470011510 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 446470011511 Ubiquitin-like proteins; Region: UBQ; cl00155 446470011512 charged pocket; other site 446470011513 hydrophobic patch; other site 446470011514 VPS10 domain; Region: VPS10; smart00602 446470011515 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446470011516 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 446470011517 putative ligand binding site [chemical binding]; other site 446470011518 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446470011519 putative NAD binding site [chemical binding]; other site 446470011520 catalytic site [active] 446470011521 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446470011522 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446470011523 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470011524 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470011525 active site 446470011526 metal binding site [ion binding]; metal-binding site 446470011527 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446470011528 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470011529 Serine hydrolase; Region: Ser_hydrolase; cl17834 446470011530 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446470011531 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 446470011532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446470011533 ATP binding site [chemical binding]; other site 446470011534 substrate binding site [chemical binding]; other site 446470011535 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470011536 active site 446470011537 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470011538 active site 446470011539 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 446470011540 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470011541 conserved cys residue [active] 446470011542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470011543 Isochorismatase family; Region: Isochorismatase; pfam00857 446470011544 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446470011545 catalytic triad [active] 446470011546 conserved cis-peptide bond; other site 446470011547 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446470011548 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446470011549 FAD binding pocket [chemical binding]; other site 446470011550 FAD binding motif [chemical binding]; other site 446470011551 phosphate binding motif [ion binding]; other site 446470011552 NAD binding pocket [chemical binding]; other site 446470011553 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446470011554 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446470011555 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_1; cd08581 446470011556 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446470011557 putative active site [active] 446470011558 catalytic site [active] 446470011559 putative metal binding site [ion binding]; other site 446470011560 hypothetical protein; Validated; Region: PRK00068 446470011561 Uncharacterized conserved protein [Function unknown]; Region: COG1615 446470011562 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446470011563 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 446470011564 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 446470011565 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446470011566 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446470011567 Protein of unknown function DUF45; Region: DUF45; pfam01863 446470011568 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 446470011569 ABC1 family; Region: ABC1; pfam03109 446470011570 serine/threonine protein kinase; Provisional; Region: PRK14879 446470011571 Transcription factor WhiB; Region: Whib; pfam02467 446470011572 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446470011573 Part of AAA domain; Region: AAA_19; pfam13245 446470011574 Family description; Region: UvrD_C_2; pfam13538 446470011575 HRDC domain; Region: HRDC; pfam00570 446470011576 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 446470011577 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446470011578 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446470011579 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446470011580 interface (dimer of trimers) [polypeptide binding]; other site 446470011581 Substrate-binding/catalytic site; other site 446470011582 Zn-binding sites [ion binding]; other site 446470011583 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446470011584 hypothetical protein; Validated; Region: PRK07883 446470011585 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446470011586 active site 446470011587 catalytic site [active] 446470011588 substrate binding site [chemical binding]; other site 446470011589 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446470011590 GIY-YIG motif/motif A; other site 446470011591 active site 446470011592 catalytic site [active] 446470011593 putative DNA binding site [nucleotide binding]; other site 446470011594 metal binding site [ion binding]; metal-binding site 446470011595 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446470011596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446470011597 Zn2+ binding site [ion binding]; other site 446470011598 Mg2+ binding site [ion binding]; other site 446470011599 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446470011600 synthetase active site [active] 446470011601 NTP binding site [chemical binding]; other site 446470011602 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 446470011603 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446470011604 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 446470011605 active site 446470011606 FMN binding site [chemical binding]; other site 446470011607 2,4-decadienoyl-CoA binding site; other site 446470011608 catalytic residue [active] 446470011609 4Fe-4S cluster binding site [ion binding]; other site 446470011610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470011611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446470011612 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470011613 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446470011614 active site 446470011615 ATP binding site [chemical binding]; other site 446470011616 substrate binding site [chemical binding]; other site 446470011617 activation loop (A-loop); other site 446470011618 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 446470011619 active site 446470011620 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446470011621 SpoOM protein; Region: Spo0M; pfam07070 446470011622 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446470011623 SpoOM protein; Region: Spo0M; pfam07070 446470011624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470011625 non-specific DNA binding site [nucleotide binding]; other site 446470011626 salt bridge; other site 446470011627 sequence-specific DNA binding site [nucleotide binding]; other site 446470011628 SpoOM protein; Region: Spo0M; pfam07070 446470011629 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446470011630 Pirin-related protein [General function prediction only]; Region: COG1741 446470011631 Pirin; Region: Pirin; pfam02678 446470011632 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446470011633 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470011634 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446470011635 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446470011636 active site 446470011637 DNA binding site [nucleotide binding] 446470011638 catalytic site [active] 446470011639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470011640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470011641 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 446470011642 active site 446470011643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470011644 non-specific DNA binding site [nucleotide binding]; other site 446470011645 salt bridge; other site 446470011646 sequence-specific DNA binding site [nucleotide binding]; other site 446470011647 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446470011648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470011649 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470011650 DNA binding residues [nucleotide binding] 446470011651 Replication-relaxation; Region: Replic_Relax; pfam13814 446470011652 GTP-binding protein Der; Reviewed; Region: PRK03003 446470011653 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 446470011654 G1 box; other site 446470011655 GTP/Mg2+ binding site [chemical binding]; other site 446470011656 Switch I region; other site 446470011657 G2 box; other site 446470011658 Switch II region; other site 446470011659 G3 box; other site 446470011660 G4 box; other site 446470011661 G5 box; other site 446470011662 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 446470011663 G1 box; other site 446470011664 GTP/Mg2+ binding site [chemical binding]; other site 446470011665 Switch I region; other site 446470011666 G2 box; other site 446470011667 G3 box; other site 446470011668 Switch II region; other site 446470011669 G4 box; other site 446470011670 G5 box; other site 446470011671 cytidylate kinase; Provisional; Region: cmk; PRK00023 446470011672 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446470011673 CMP-binding site; other site 446470011674 The sites determining sugar specificity; other site 446470011675 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446470011676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446470011677 RNA binding surface [nucleotide binding]; other site 446470011678 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 446470011679 active site 446470011680 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 446470011681 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 446470011682 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446470011683 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446470011684 P-loop; other site 446470011685 Magnesium ion binding site [ion binding]; other site 446470011686 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446470011687 Magnesium ion binding site [ion binding]; other site 446470011688 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446470011689 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 446470011690 active site 446470011691 Int/Topo IB signature motif; other site 446470011692 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446470011693 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 446470011694 hexamer interface [polypeptide binding]; other site 446470011695 ligand binding site [chemical binding]; other site 446470011696 putative active site [active] 446470011697 NAD(P) binding site [chemical binding]; other site 446470011698 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446470011699 dimer interface [polypeptide binding]; other site 446470011700 ADP-ribose binding site [chemical binding]; other site 446470011701 active site 446470011702 nudix motif; other site 446470011703 metal binding site [ion binding]; metal-binding site 446470011704 CTP synthetase; Validated; Region: pyrG; PRK05380 446470011705 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 446470011706 Catalytic site [active] 446470011707 active site 446470011708 UTP binding site [chemical binding]; other site 446470011709 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446470011710 active site 446470011711 putative oxyanion hole; other site 446470011712 catalytic triad [active] 446470011713 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 446470011714 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446470011715 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446470011716 Thiamine pyrophosphokinase; Region: TPK; cl08415 446470011717 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446470011718 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446470011719 Walker A/P-loop; other site 446470011720 ATP binding site [chemical binding]; other site 446470011721 Q-loop/lid; other site 446470011722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470011723 ABC transporter signature motif; other site 446470011724 Walker B; other site 446470011725 D-loop; other site 446470011726 H-loop/switch region; other site 446470011727 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 446470011728 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 446470011729 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446470011730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446470011731 RNA binding surface [nucleotide binding]; other site 446470011732 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 446470011733 SCP-2 sterol transfer family; Region: SCP2; pfam02036 446470011734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470011735 UMP phosphatase; Provisional; Region: PRK10444 446470011736 motif II; other site 446470011737 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446470011738 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446470011739 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446470011740 active site 446470011741 HIGH motif; other site 446470011742 dimer interface [polypeptide binding]; other site 446470011743 KMSKS motif; other site 446470011744 S4 RNA-binding domain; Region: S4; smart00363 446470011745 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 446470011746 active site 446470011747 DNA binding site [nucleotide binding] 446470011748 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 446470011749 RNB domain; Region: RNB; pfam00773 446470011750 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446470011751 hypothetical protein; Reviewed; Region: PRK09588 446470011752 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 446470011753 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446470011754 active site 446470011755 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446470011756 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446470011757 putative dimer interface [polypeptide binding]; other site 446470011758 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 446470011759 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 446470011760 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 446470011761 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470011762 WYL domain; Region: WYL; pfam13280 446470011763 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470011764 WYL domain; Region: WYL; pfam13280 446470011765 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 446470011766 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446470011767 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 446470011768 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446470011769 active site 446470011770 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 446470011771 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446470011772 active site 446470011773 Pup-like protein; Region: Pup; pfam05639 446470011774 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 446470011775 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446470011776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011777 NAD(P) binding site [chemical binding]; other site 446470011778 active site 446470011779 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 446470011780 homodimer interface [polypeptide binding]; other site 446470011781 chemical substrate binding site [chemical binding]; other site 446470011782 oligomer interface [polypeptide binding]; other site 446470011783 metal binding site [ion binding]; metal-binding site 446470011784 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 446470011785 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 446470011786 catalytic triad [active] 446470011787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446470011788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470011789 Coenzyme A binding pocket [chemical binding]; other site 446470011790 Lamin Tail Domain; Region: LTD; pfam00932 446470011791 proteasome ATPase; Region: pup_AAA; TIGR03689 446470011792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470011793 Walker A motif; other site 446470011794 ATP binding site [chemical binding]; other site 446470011795 Walker B motif; other site 446470011796 arginine finger; other site 446470011797 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446470011798 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 446470011799 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446470011800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470011801 S-adenosylmethionine binding site [chemical binding]; other site 446470011802 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 446470011803 Peptidase family M50; Region: Peptidase_M50; pfam02163 446470011804 active site 446470011805 putative substrate binding region [chemical binding]; other site 446470011806 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446470011807 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446470011808 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446470011809 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446470011810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470011811 Histidine kinase; Region: HisKA_3; pfam07730 446470011812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470011813 ATP binding site [chemical binding]; other site 446470011814 Mg2+ binding site [ion binding]; other site 446470011815 G-X-G motif; other site 446470011816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470011817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470011818 active site 446470011819 phosphorylation site [posttranslational modification] 446470011820 intermolecular recognition site; other site 446470011821 dimerization interface [polypeptide binding]; other site 446470011822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470011823 dimerization interface [polypeptide binding]; other site 446470011824 DNA binding residues [nucleotide binding] 446470011825 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470011826 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470011827 Walker A/P-loop; other site 446470011828 ATP binding site [chemical binding]; other site 446470011829 Q-loop/lid; other site 446470011830 ABC transporter signature motif; other site 446470011831 Walker B; other site 446470011832 D-loop; other site 446470011833 H-loop/switch region; other site 446470011834 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470011835 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446470011836 FtsX-like permease family; Region: FtsX; pfam02687 446470011837 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446470011838 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470011839 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470011840 DNA binding site [nucleotide binding] 446470011841 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470011842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470011843 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470011844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470011845 binding surface 446470011846 TPR motif; other site 446470011847 TPR repeat; Region: TPR_11; pfam13414 446470011848 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 446470011849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470011850 putative substrate translocation pore; other site 446470011851 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446470011852 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 446470011853 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 446470011854 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446470011855 putative active site [active] 446470011856 putative metal binding site [ion binding]; other site 446470011857 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470011858 nudix motif; other site 446470011859 Smr domain; Region: Smr; pfam01713 446470011860 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 446470011861 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 446470011862 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470011863 active site 446470011864 nucleotide binding site [chemical binding]; other site 446470011865 HIGH motif; other site 446470011866 KMSKS motif; other site 446470011867 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 446470011868 PemK-like protein; Region: PemK; pfam02452 446470011869 OsmC-like protein; Region: OsmC; cl00767 446470011870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 446470011871 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 446470011872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470011873 active site 446470011874 motif I; other site 446470011875 motif II; other site 446470011876 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 446470011877 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 446470011878 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 446470011879 substrate binding pocket [chemical binding]; other site 446470011880 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 446470011881 B12 binding site [chemical binding]; other site 446470011882 cobalt ligand [ion binding]; other site 446470011883 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 446470011884 PAC2 family; Region: PAC2; pfam09754 446470011885 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 446470011886 putative active site [active] 446470011887 putative substrate binding site [chemical binding]; other site 446470011888 putative cosubstrate binding site; other site 446470011889 catalytic site [active] 446470011890 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 446470011891 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446470011892 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470011893 substrate binding site [chemical binding]; other site 446470011894 oxyanion hole (OAH) forming residues; other site 446470011895 trimer interface [polypeptide binding]; other site 446470011896 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470011897 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 446470011898 active site 446470011899 HIGH motif; other site 446470011900 nucleotide binding site [chemical binding]; other site 446470011901 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470011902 active site 446470011903 KMSKS motif; other site 446470011904 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446470011905 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 446470011906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470011907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470011908 active site 446470011909 catalytic tetrad [active] 446470011910 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446470011911 active site 446470011912 catalytic triad [active] 446470011913 oxyanion hole [active] 446470011914 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470011915 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470011916 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 446470011917 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 446470011918 Phosphotransferase enzyme family; Region: APH; pfam01636 446470011919 putative active site [active] 446470011920 putative substrate binding site [chemical binding]; other site 446470011921 ATP binding site [chemical binding]; other site 446470011922 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470011923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011924 NAD(P) binding site [chemical binding]; other site 446470011925 active site 446470011926 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 446470011927 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 446470011928 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446470011929 siderophore binding site; other site 446470011930 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446470011931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446470011932 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470011933 ABC-ATPase subunit interface; other site 446470011934 dimer interface [polypeptide binding]; other site 446470011935 putative PBP binding regions; other site 446470011936 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470011937 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470011938 ABC-ATPase subunit interface; other site 446470011939 dimer interface [polypeptide binding]; other site 446470011940 putative PBP binding regions; other site 446470011941 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470011942 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470011943 Walker A/P-loop; other site 446470011944 ATP binding site [chemical binding]; other site 446470011945 Q-loop/lid; other site 446470011946 ABC transporter signature motif; other site 446470011947 Walker B; other site 446470011948 D-loop; other site 446470011949 H-loop/switch region; other site 446470011950 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 446470011951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011952 NAD(P) binding site [chemical binding]; other site 446470011953 active site 446470011954 isochorismate synthase DhbC; Validated; Region: PRK06923 446470011955 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446470011956 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 446470011957 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 446470011958 acyl-activating enzyme (AAE) consensus motif; other site 446470011959 active site 446470011960 AMP binding site [chemical binding]; other site 446470011961 substrate binding site [chemical binding]; other site 446470011962 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446470011963 Isochorismatase family; Region: Isochorismatase; pfam00857 446470011964 catalytic triad [active] 446470011965 conserved cis-peptide bond; other site 446470011966 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446470011967 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 446470011968 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446470011969 Condensation domain; Region: Condensation; pfam00668 446470011970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470011971 acyl-activating enzyme (AAE) consensus motif; other site 446470011972 active site 446470011973 AMP binding site [chemical binding]; other site 446470011974 CoA binding site [chemical binding]; other site 446470011975 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470011976 CoA binding site [chemical binding]; other site 446470011977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446470011978 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446470011979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470011980 NAD(P) binding site [chemical binding]; other site 446470011981 active site 446470011982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470011983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470011984 dimerization interface [polypeptide binding]; other site 446470011985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470011986 dimer interface [polypeptide binding]; other site 446470011987 phosphorylation site [posttranslational modification] 446470011988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470011989 ATP binding site [chemical binding]; other site 446470011990 Mg2+ binding site [ion binding]; other site 446470011991 G-X-G motif; other site 446470011992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470011993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470011994 active site 446470011995 phosphorylation site [posttranslational modification] 446470011996 intermolecular recognition site; other site 446470011997 dimerization interface [polypeptide binding]; other site 446470011998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470011999 DNA binding site [nucleotide binding] 446470012000 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446470012001 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446470012002 TPP-binding site; other site 446470012003 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446470012004 PYR/PP interface [polypeptide binding]; other site 446470012005 dimer interface [polypeptide binding]; other site 446470012006 TPP binding site [chemical binding]; other site 446470012007 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446470012008 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470012009 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446470012010 active site 446470012011 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446470012012 TRAM domain; Region: TRAM; pfam01938 446470012013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470012014 S-adenosylmethionine binding site [chemical binding]; other site 446470012015 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446470012016 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446470012017 TrkA-N domain; Region: TrkA_N; pfam02254 446470012018 TrkA-C domain; Region: TrkA_C; pfam02080 446470012019 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446470012020 TrkA-N domain; Region: TrkA_N; pfam02254 446470012021 TrkA-C domain; Region: TrkA_C; pfam02080 446470012022 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446470012023 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446470012024 ssDNA binding site; other site 446470012025 generic binding surface II; other site 446470012026 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446470012027 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446470012028 trimer interface [polypeptide binding]; other site 446470012029 active site 446470012030 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 446470012031 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 446470012032 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446470012033 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446470012034 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446470012035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470012036 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446470012037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470012038 DNA binding residues [nucleotide binding] 446470012039 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446470012040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470012041 ATP binding site [chemical binding]; other site 446470012042 putative Mg++ binding site [ion binding]; other site 446470012043 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 446470012044 putative active site [active] 446470012045 dimerization interface [polypeptide binding]; other site 446470012046 putative tRNAtyr binding site [nucleotide binding]; other site 446470012047 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 446470012048 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446470012049 Predicted membrane protein [Function unknown]; Region: COG2860 446470012050 UPF0126 domain; Region: UPF0126; pfam03458 446470012051 UPF0126 domain; Region: UPF0126; pfam03458 446470012052 Penicillinase repressor; Region: Pencillinase_R; cl17580 446470012053 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446470012054 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446470012055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470012056 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446470012057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470012058 DNA binding residues [nucleotide binding] 446470012059 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446470012060 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 446470012061 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446470012062 FeoA domain; Region: FeoA; pfam04023 446470012063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470012064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470012065 active site 446470012066 catalytic tetrad [active] 446470012067 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446470012068 catalytic motif [active] 446470012069 Zn binding site [ion binding]; other site 446470012070 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446470012071 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446470012072 active site residue [active] 446470012073 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446470012074 active site residue [active] 446470012075 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446470012076 RibD C-terminal domain; Region: RibD_C; cl17279 446470012077 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446470012078 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446470012079 substrate binding pocket [chemical binding]; other site 446470012080 membrane-bound complex binding site; other site 446470012081 hinge residues; other site 446470012082 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446470012083 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446470012084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470012085 active site 446470012086 ATP binding site [chemical binding]; other site 446470012087 substrate binding site [chemical binding]; other site 446470012088 activation loop (A-loop); other site 446470012089 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446470012090 active site 446470012091 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446470012092 metal ion-dependent adhesion site (MIDAS); other site 446470012093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446470012094 phosphopeptide binding site; other site 446470012095 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470012096 PLD-like domain; Region: PLDc_2; pfam13091 446470012097 PLD-like domain; Region: PLDc_2; pfam13091 446470012098 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470012099 putative active site [active] 446470012100 catalytic site [active] 446470012101 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 446470012102 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 446470012103 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 446470012104 active site 446470012105 dimer interface [polypeptide binding]; other site 446470012106 effector binding site; other site 446470012107 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 446470012108 TSCPD domain; Region: TSCPD; pfam12637 446470012109 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446470012110 ATP cone domain; Region: ATP-cone; pfam03477 446470012111 LexA repressor; Validated; Region: PRK00215 446470012112 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 446470012113 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446470012114 Catalytic site [active] 446470012115 GTPases [General function prediction only]; Region: HflX; COG2262 446470012116 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 446470012117 HflX GTPase family; Region: HflX; cd01878 446470012118 G1 box; other site 446470012119 GTP/Mg2+ binding site [chemical binding]; other site 446470012120 Switch I region; other site 446470012121 G2 box; other site 446470012122 G3 box; other site 446470012123 Switch II region; other site 446470012124 G4 box; other site 446470012125 G5 box; other site 446470012126 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446470012127 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446470012128 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446470012129 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446470012130 putative NAD(P) binding site [chemical binding]; other site 446470012131 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470012132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470012133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470012134 DNA binding residues [nucleotide binding] 446470012135 Protein of unknown function (DUF419); Region: DUF419; cl15265 446470012136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470012137 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470012138 active site 446470012139 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446470012140 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446470012141 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446470012142 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 446470012143 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 446470012144 active site pocket [active] 446470012145 putative cataytic base [active] 446470012146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012148 active site 446470012149 phosphorylation site [posttranslational modification] 446470012150 intermolecular recognition site; other site 446470012151 dimerization interface [polypeptide binding]; other site 446470012152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012153 DNA binding residues [nucleotide binding] 446470012154 dimerization interface [polypeptide binding]; other site 446470012155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470012156 WzyE protein; Region: WzyE; cl11643 446470012157 Histidine kinase; Region: HisKA_3; pfam07730 446470012158 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470012159 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 446470012160 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446470012161 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012163 active site 446470012164 phosphorylation site [posttranslational modification] 446470012165 intermolecular recognition site; other site 446470012166 dimerization interface [polypeptide binding]; other site 446470012167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012168 DNA binding residues [nucleotide binding] 446470012169 dimerization interface [polypeptide binding]; other site 446470012170 Histidine kinase; Region: HisKA_3; pfam07730 446470012171 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470012172 ATP binding site [chemical binding]; other site 446470012173 Mg2+ binding site [ion binding]; other site 446470012174 G-X-G motif; other site 446470012175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470012176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470012177 active site 446470012178 catalytic tetrad [active] 446470012179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470012180 salt bridge; other site 446470012181 non-specific DNA binding site [nucleotide binding]; other site 446470012182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470012183 sequence-specific DNA binding site [nucleotide binding]; other site 446470012184 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 446470012185 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 446470012186 Chromate transporter; Region: Chromate_transp; pfam02417 446470012187 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470012188 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470012189 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470012190 hypothetical protein; Provisional; Region: PRK07236 446470012191 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470012192 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470012193 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446470012194 Family description; Region: UvrD_C_2; pfam13538 446470012195 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446470012196 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446470012197 Part of AAA domain; Region: AAA_19; pfam13245 446470012198 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446470012199 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446470012200 active site 446470012201 catalytic triad [active] 446470012202 oxyanion hole [active] 446470012203 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 446470012204 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 446470012205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470012206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012207 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470012208 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470012209 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 446470012210 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446470012211 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446470012212 ATP binding site [chemical binding]; other site 446470012213 substrate interface [chemical binding]; other site 446470012214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446470012215 active site residue [active] 446470012216 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446470012217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470012218 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446470012219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470012220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470012221 DNA binding residues [nucleotide binding] 446470012222 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446470012223 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446470012224 Walker A/P-loop; other site 446470012225 ATP binding site [chemical binding]; other site 446470012226 Q-loop/lid; other site 446470012227 ABC transporter signature motif; other site 446470012228 Walker B; other site 446470012229 D-loop; other site 446470012230 H-loop/switch region; other site 446470012231 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446470012232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012233 dimer interface [polypeptide binding]; other site 446470012234 conserved gate region; other site 446470012235 putative PBP binding loops; other site 446470012236 ABC-ATPase subunit interface; other site 446470012237 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446470012238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012239 dimer interface [polypeptide binding]; other site 446470012240 conserved gate region; other site 446470012241 putative PBP binding loops; other site 446470012242 ABC-ATPase subunit interface; other site 446470012243 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446470012244 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446470012245 substrate binding pocket [chemical binding]; other site 446470012246 membrane-bound complex binding site; other site 446470012247 hinge residues; other site 446470012248 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 446470012249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470012250 DNA-binding site [nucleotide binding]; DNA binding site 446470012251 FCD domain; Region: FCD; pfam07729 446470012252 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 446470012253 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446470012254 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446470012255 ATP binding site [chemical binding]; other site 446470012256 Mg++ binding site [ion binding]; other site 446470012257 motif III; other site 446470012258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470012259 nucleotide binding region [chemical binding]; other site 446470012260 ATP-binding site [chemical binding]; other site 446470012261 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 446470012262 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446470012263 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470012264 MarR family; Region: MarR; pfam01047 446470012265 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470012266 PLD-like domain; Region: PLDc_2; pfam13091 446470012267 putative active site [active] 446470012268 catalytic site [active] 446470012269 PLD-like domain; Region: PLDc_2; pfam13091 446470012270 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470012271 putative active site [active] 446470012272 catalytic site [active] 446470012273 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470012274 putative catalytic site [active] 446470012275 putative metal binding site [ion binding]; other site 446470012276 putative phosphate binding site [ion binding]; other site 446470012277 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 446470012278 heme binding pocket [chemical binding]; other site 446470012279 heme ligand [chemical binding]; other site 446470012280 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 446470012281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470012282 S-adenosylmethionine binding site [chemical binding]; other site 446470012283 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 446470012284 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470012285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470012286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470012287 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 446470012288 putative ADP-ribose binding site [chemical binding]; other site 446470012289 putative active site [active] 446470012290 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446470012291 active site 446470012292 catalytic residues [active] 446470012293 GTPase Era; Reviewed; Region: era; PRK00089 446470012294 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 446470012295 G1 box; other site 446470012296 GTP/Mg2+ binding site [chemical binding]; other site 446470012297 Switch I region; other site 446470012298 G2 box; other site 446470012299 Switch II region; other site 446470012300 G3 box; other site 446470012301 G4 box; other site 446470012302 G5 box; other site 446470012303 KH domain; Region: KH_2; pfam07650 446470012304 Domain of unknown function DUF21; Region: DUF21; pfam01595 446470012305 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446470012306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446470012307 Transporter associated domain; Region: CorC_HlyC; smart01091 446470012308 metal-binding heat shock protein; Provisional; Region: PRK00016 446470012309 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 446470012310 PhoH-like protein; Region: PhoH; pfam02562 446470012311 Repair protein; Region: Repair_PSII; pfam04536 446470012312 replication initiation protein RepC; Provisional; Region: PRK13824 446470012313 kynureninase; Region: kynureninase; TIGR01814 446470012314 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470012315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470012316 catalytic residue [active] 446470012317 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446470012318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470012319 putative DNA binding site [nucleotide binding]; other site 446470012320 putative Zn2+ binding site [ion binding]; other site 446470012321 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446470012322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446470012323 active site 446470012324 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446470012325 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446470012326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470012327 putative substrate translocation pore; other site 446470012328 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 446470012329 apolar tunnel; other site 446470012330 heme binding site [chemical binding]; other site 446470012331 dimerization interface [polypeptide binding]; other site 446470012332 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 446470012333 Zn binding site [ion binding]; other site 446470012334 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446470012335 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 446470012336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446470012337 active site 446470012338 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446470012339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470012340 Walker A/P-loop; other site 446470012341 ATP binding site [chemical binding]; other site 446470012342 Q-loop/lid; other site 446470012343 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446470012344 ABC transporter; Region: ABC_tran_2; pfam12848 446470012345 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446470012346 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 446470012347 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446470012348 active site 446470012349 homotetramer interface [polypeptide binding]; other site 446470012350 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 446470012351 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 446470012352 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446470012353 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446470012354 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470012355 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470012356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012357 dimer interface [polypeptide binding]; other site 446470012358 conserved gate region; other site 446470012359 putative PBP binding loops; other site 446470012360 ABC-ATPase subunit interface; other site 446470012361 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470012362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012363 dimer interface [polypeptide binding]; other site 446470012364 conserved gate region; other site 446470012365 putative PBP binding loops; other site 446470012366 ABC-ATPase subunit interface; other site 446470012367 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446470012368 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446470012369 Walker A/P-loop; other site 446470012370 ATP binding site [chemical binding]; other site 446470012371 Q-loop/lid; other site 446470012372 ABC transporter signature motif; other site 446470012373 Walker B; other site 446470012374 D-loop; other site 446470012375 H-loop/switch region; other site 446470012376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470012377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470012378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012379 dimer interface [polypeptide binding]; other site 446470012380 conserved gate region; other site 446470012381 putative PBP binding loops; other site 446470012382 ABC-ATPase subunit interface; other site 446470012383 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470012384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012385 dimer interface [polypeptide binding]; other site 446470012386 conserved gate region; other site 446470012387 putative PBP binding loops; other site 446470012388 ABC-ATPase subunit interface; other site 446470012389 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446470012390 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446470012391 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446470012392 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446470012393 AP (apurinic/apyrimidinic) site pocket; other site 446470012394 DNA interaction; other site 446470012395 Metal-binding active site; metal-binding site 446470012396 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 446470012397 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446470012398 putative ligand binding site [chemical binding]; other site 446470012399 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470012400 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470012401 TM-ABC transporter signature motif; other site 446470012402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470012403 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446470012404 TM-ABC transporter signature motif; other site 446470012405 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446470012406 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446470012407 Walker A/P-loop; other site 446470012408 ATP binding site [chemical binding]; other site 446470012409 Q-loop/lid; other site 446470012410 ABC transporter signature motif; other site 446470012411 Walker B; other site 446470012412 D-loop; other site 446470012413 H-loop/switch region; other site 446470012414 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446470012415 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470012416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470012417 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446470012418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470012419 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470012420 putative DNA binding site [nucleotide binding]; other site 446470012421 putative Zn2+ binding site [ion binding]; other site 446470012422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470012423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470012424 multicopper oxidase; Provisional; Region: PRK10965 446470012425 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 446470012426 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 446470012427 Histidine kinase; Region: HisKA_3; pfam07730 446470012428 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470012429 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012431 active site 446470012432 phosphorylation site [posttranslational modification] 446470012433 intermolecular recognition site; other site 446470012434 dimerization interface [polypeptide binding]; other site 446470012435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012436 DNA binding residues [nucleotide binding] 446470012437 dimerization interface [polypeptide binding]; other site 446470012438 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 446470012439 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 446470012440 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446470012441 active site 446470012442 SAM binding site [chemical binding]; other site 446470012443 homodimer interface [polypeptide binding]; other site 446470012444 Transglycosylase; Region: Transgly; pfam00912 446470012445 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446470012446 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446470012447 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446470012448 hypothetical protein; Provisional; Region: PRK07907 446470012449 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 446470012450 active site 446470012451 metal binding site [ion binding]; metal-binding site 446470012452 dimer interface [polypeptide binding]; other site 446470012453 hypothetical protein; Provisional; Region: PRK06547 446470012454 AAA domain; Region: AAA_18; pfam13238 446470012455 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446470012456 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446470012457 dimer interface [polypeptide binding]; other site 446470012458 ssDNA binding site [nucleotide binding]; other site 446470012459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446470012460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470012461 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446470012462 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446470012463 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446470012464 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446470012465 sugar binding site [chemical binding]; other site 446470012466 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446470012467 putative active site [active] 446470012468 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470012469 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 446470012470 DNA binding residues [nucleotide binding] 446470012471 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446470012472 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 446470012473 nucleophile elbow; other site 446470012474 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 446470012475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470012476 FeS/SAM binding site; other site 446470012477 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 446470012478 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 446470012479 Flavoprotein; Region: Flavoprotein; pfam02441 446470012480 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470012481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012483 DNA binding residues [nucleotide binding] 446470012484 dimerization interface [polypeptide binding]; other site 446470012485 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470012486 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470012487 Walker A/P-loop; other site 446470012488 ATP binding site [chemical binding]; other site 446470012489 Q-loop/lid; other site 446470012490 ABC transporter signature motif; other site 446470012491 Walker B; other site 446470012492 D-loop; other site 446470012493 H-loop/switch region; other site 446470012494 MarR family; Region: MarR_2; pfam12802 446470012495 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 446470012496 Clp amino terminal domain; Region: Clp_N; pfam02861 446470012497 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470012498 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470012499 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470012500 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470012501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470012502 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470012503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470012504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470012505 DNA binding site [nucleotide binding] 446470012506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470012507 dimerization interface [polypeptide binding]; other site 446470012508 ligand binding site [chemical binding]; other site 446470012509 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446470012510 active site 446470012511 catalytic site [active] 446470012512 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446470012513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470012514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446470012515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012516 dimer interface [polypeptide binding]; other site 446470012517 conserved gate region; other site 446470012518 putative PBP binding loops; other site 446470012519 ABC-ATPase subunit interface; other site 446470012520 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470012521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470012522 dimer interface [polypeptide binding]; other site 446470012523 conserved gate region; other site 446470012524 putative PBP binding loops; other site 446470012525 ABC-ATPase subunit interface; other site 446470012526 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 446470012527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470012528 putative substrate translocation pore; other site 446470012529 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 446470012530 intracellular protease, PfpI family; Region: PfpI; TIGR01382 446470012531 proposed catalytic triad [active] 446470012532 conserved cys residue [active] 446470012533 Gas vesicle protein K; Region: GvpK; pfam05121 446470012534 Gas vesicle protein; Region: Gas_vesicle; cl02954 446470012535 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 446470012536 Gas vesicle protein; Region: Gas_vesicle; pfam00741 446470012537 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 446470012538 Gas vesicle protein G; Region: GvpG; pfam05120 446470012539 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 446470012540 Gas vesicle protein; Region: Gas_vesicle; cl02954 446470012541 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470012542 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470012543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446470012544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470012545 NAD(P) binding site [chemical binding]; other site 446470012546 active site 446470012547 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 446470012548 putative active site [active] 446470012549 redox center [active] 446470012550 Methyltransferase domain; Region: Methyltransf_11; pfam08241 446470012551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470012552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470012553 S-adenosylmethionine binding site [chemical binding]; other site 446470012554 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 446470012555 putative catalytic residues [active] 446470012556 multidrug resistance protein MdtH; Provisional; Region: PRK11646 446470012557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470012558 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446470012559 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446470012560 dimer interface [polypeptide binding]; other site 446470012561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470012562 catalytic residue [active] 446470012563 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470012564 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470012565 Phosphotransferase enzyme family; Region: APH; pfam01636 446470012566 active site 446470012567 substrate binding site [chemical binding]; other site 446470012568 ATP binding site [chemical binding]; other site 446470012569 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470012570 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470012571 active site 446470012572 ATP binding site [chemical binding]; other site 446470012573 substrate binding site [chemical binding]; other site 446470012574 activation loop (A-loop); other site 446470012575 hydrophobic ligand binding site; other site 446470012576 Activator of Hsp90 ATPase homolog 1-like protein; Region: AHSA1; pfam08327 446470012577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012579 active site 446470012580 phosphorylation site [posttranslational modification] 446470012581 intermolecular recognition site; other site 446470012582 dimerization interface [polypeptide binding]; other site 446470012583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012584 DNA binding residues [nucleotide binding] 446470012585 dimerization interface [polypeptide binding]; other site 446470012586 Putative sensor; Region: Sensor; pfam13796 446470012587 Histidine kinase; Region: HisKA_3; pfam07730 446470012588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470012589 ATP binding site [chemical binding]; other site 446470012590 Mg2+ binding site [ion binding]; other site 446470012591 G-X-G motif; other site 446470012592 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470012593 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470012594 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470012595 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446470012596 Phosphotransferase enzyme family; Region: APH; pfam01636 446470012597 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470012598 active site 446470012599 substrate binding site [chemical binding]; other site 446470012600 ATP binding site [chemical binding]; other site 446470012601 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446470012602 active site 446470012603 Erythromycin esterase; Region: Erythro_esteras; cl17110 446470012604 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470012605 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470012606 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470012607 active site 446470012608 ATP binding site [chemical binding]; other site 446470012609 substrate binding site [chemical binding]; other site 446470012610 activation loop (A-loop); other site 446470012611 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446470012612 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 446470012613 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470012614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446470012615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470012616 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470012617 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446470012618 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 446470012619 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470012620 HTH domain; Region: HTH_11; pfam08279 446470012621 WYL domain; Region: WYL; pfam13280 446470012622 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 446470012623 active site 446470012624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470012625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012626 Predicted membrane protein [Function unknown]; Region: COG2311 446470012627 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446470012628 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446470012629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470012630 NAD(P) binding site [chemical binding]; other site 446470012631 active site 446470012632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470012633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012634 Penicillinase repressor; Region: Pencillinase_R; pfam03965 446470012635 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 446470012636 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446470012637 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 446470012638 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 446470012639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470012640 non-specific DNA binding site [nucleotide binding]; other site 446470012641 salt bridge; other site 446470012642 sequence-specific DNA binding site [nucleotide binding]; other site 446470012643 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470012644 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470012645 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470012646 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470012647 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446470012648 SnoaL-like domain; Region: SnoaL_3; pfam13474 446470012649 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446470012650 Phosphotransferase enzyme family; Region: APH; pfam01636 446470012651 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446470012652 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470012653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470012654 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470012655 YCII-related domain; Region: YCII; cl00999 446470012656 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470012657 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446470012658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470012659 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470012660 Walker A/P-loop; other site 446470012661 ATP binding site [chemical binding]; other site 446470012662 Q-loop/lid; other site 446470012663 ABC transporter signature motif; other site 446470012664 Walker B; other site 446470012665 D-loop; other site 446470012666 H-loop/switch region; other site 446470012667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470012668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012669 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470012670 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470012671 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 446470012672 putative NAD(P) binding site [chemical binding]; other site 446470012673 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 446470012674 DoxX-like family; Region: DoxX_2; pfam13564 446470012675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470012676 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446470012677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470012678 Coenzyme A binding pocket [chemical binding]; other site 446470012679 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446470012680 active site residue [active] 446470012681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470012682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470012684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470012685 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470012686 hypothetical protein; Provisional; Region: PRK07236 446470012687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470012688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012689 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470012690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470012691 S-adenosylmethionine binding site [chemical binding]; other site 446470012692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470012693 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470012694 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 446470012695 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 446470012696 active site 446470012697 Zn binding site [ion binding]; other site 446470012698 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 446470012699 putative FMN binding site [chemical binding]; other site 446470012700 putative dimer interface [polypeptide binding]; other site 446470012701 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470012702 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470012703 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470012704 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470012705 HTH domain; Region: HTH_11; pfam08279 446470012706 WYL domain; Region: WYL; pfam13280 446470012707 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446470012708 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 446470012709 dimer interface [polypeptide binding]; other site 446470012710 catalytic triad [active] 446470012711 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446470012712 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446470012713 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446470012714 dimer interface [polypeptide binding]; other site 446470012715 TPP-binding site [chemical binding]; other site 446470012716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470012717 S-adenosylmethionine binding site [chemical binding]; other site 446470012718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446470012719 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446470012720 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 446470012721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470012722 catalytic residue [active] 446470012723 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446470012724 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470012725 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 446470012726 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 446470012727 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446470012728 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446470012729 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 446470012730 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446470012731 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446470012732 dimer interface [polypeptide binding]; other site 446470012733 active site 446470012734 CoA binding pocket [chemical binding]; other site 446470012735 acyl carrier protein; Provisional; Region: acpP; PRK00982 446470012736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446470012737 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446470012738 dimer interface [polypeptide binding]; other site 446470012739 active site 446470012740 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446470012741 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446470012742 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446470012743 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 446470012744 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470012745 conserved cys residue [active] 446470012746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470012747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470012748 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 446470012749 RNA/DNA hybrid binding site [nucleotide binding]; other site 446470012750 active site 446470012751 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 446470012752 Putative zinc ribbon domain; Region: DUF164; pfam02591 446470012753 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446470012754 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 446470012755 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470012756 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470012757 structural tetrad; other site 446470012758 Flavoprotein; Region: Flavoprotein; cl08021 446470012759 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446470012760 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446470012761 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446470012762 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446470012763 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446470012764 intersubunit interface [polypeptide binding]; other site 446470012765 Uncharacterized conserved protein [Function unknown]; Region: COG0398 446470012766 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446470012767 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446470012768 oligomerization interface [polypeptide binding]; other site 446470012769 active site 446470012770 metal binding site [ion binding]; metal-binding site 446470012771 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 446470012772 tartrate dehydrogenase; Provisional; Region: PRK08194 446470012773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470012774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470012775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446470012776 dimerization interface [polypeptide binding]; other site 446470012777 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 446470012778 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 446470012779 transmembrane helices; other site 446470012780 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446470012781 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446470012782 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446470012783 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470012784 Cytochrome P450; Region: p450; cl12078 446470012785 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446470012786 ATP binding site [chemical binding]; other site 446470012787 active site 446470012788 substrate binding site [chemical binding]; other site 446470012789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470012790 Histidine kinase; Region: HisKA_3; pfam07730 446470012791 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470012792 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012794 active site 446470012795 phosphorylation site [posttranslational modification] 446470012796 intermolecular recognition site; other site 446470012797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012798 DNA binding residues [nucleotide binding] 446470012799 dimerization interface [polypeptide binding]; other site 446470012800 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 446470012801 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446470012802 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470012803 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446470012804 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470012805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470012806 Walker A/P-loop; other site 446470012807 ATP binding site [chemical binding]; other site 446470012808 Q-loop/lid; other site 446470012809 ABC transporter signature motif; other site 446470012810 Walker B; other site 446470012811 D-loop; other site 446470012812 H-loop/switch region; other site 446470012813 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 446470012814 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470012815 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446470012816 active site 446470012817 metal binding site [ion binding]; metal-binding site 446470012818 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446470012819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470012820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012821 active site 446470012822 phosphorylation site [posttranslational modification] 446470012823 intermolecular recognition site; other site 446470012824 dimerization interface [polypeptide binding]; other site 446470012825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470012826 DNA binding site [nucleotide binding] 446470012827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470012828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470012829 dimer interface [polypeptide binding]; other site 446470012830 phosphorylation site [posttranslational modification] 446470012831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470012832 ATP binding site [chemical binding]; other site 446470012833 Mg2+ binding site [ion binding]; other site 446470012834 G-X-G motif; other site 446470012835 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470012836 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470012837 nudix motif; other site 446470012838 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470012839 nudix motif; other site 446470012840 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470012841 active site 446470012842 metal binding site [ion binding]; metal-binding site 446470012843 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470012844 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446470012845 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446470012846 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 446470012847 trimer interface [polypeptide binding]; other site 446470012848 active site 446470012849 substrate binding site [chemical binding]; other site 446470012850 CoA binding site [chemical binding]; other site 446470012851 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470012852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470012853 S-adenosylmethionine binding site [chemical binding]; other site 446470012854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470012855 enoyl-CoA hydratase; Provisional; Region: PRK05862 446470012856 substrate binding site [chemical binding]; other site 446470012857 oxyanion hole (OAH) forming residues; other site 446470012858 trimer interface [polypeptide binding]; other site 446470012859 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446470012860 active site 446470012861 catalytic triad [active] 446470012862 oxyanion hole [active] 446470012863 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446470012864 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470012865 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446470012866 Walker A/P-loop; other site 446470012867 ATP binding site [chemical binding]; other site 446470012868 ABC transporter signature motif; other site 446470012869 Walker B; other site 446470012870 D-loop; other site 446470012871 H-loop/switch region; other site 446470012872 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446470012873 Ligand binding site; other site 446470012874 Putative Catalytic site; other site 446470012875 DXD motif; other site 446470012876 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 446470012877 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 446470012878 active site 446470012879 Zn binding site [ion binding]; other site 446470012880 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 446470012881 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 446470012882 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 446470012883 MgtC family; Region: MgtC; pfam02308 446470012884 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 446470012885 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 446470012886 nudix motif; other site 446470012887 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446470012888 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446470012889 metal binding site [ion binding]; metal-binding site 446470012890 dimer interface [polypeptide binding]; other site 446470012891 Uncharacterized conserved protein [Function unknown]; Region: COG1915 446470012892 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 446470012893 homodimer interface [polypeptide binding]; other site 446470012894 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446470012895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470012896 nucleotide binding site [chemical binding]; other site 446470012897 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 446470012898 putative hydrophobic ligand binding site [chemical binding]; other site 446470012899 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446470012900 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446470012901 acyl-activating enzyme (AAE) consensus motif; other site 446470012902 putative AMP binding site [chemical binding]; other site 446470012903 putative active site [active] 446470012904 putative CoA binding site [chemical binding]; other site 446470012905 GAF domain; Region: GAF_3; pfam13492 446470012906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470012907 Histidine kinase; Region: HisKA_3; pfam07730 446470012908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470012909 ATP binding site [chemical binding]; other site 446470012910 Mg2+ binding site [ion binding]; other site 446470012911 G-X-G motif; other site 446470012912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470012913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012914 active site 446470012915 phosphorylation site [posttranslational modification] 446470012916 intermolecular recognition site; other site 446470012917 dimerization interface [polypeptide binding]; other site 446470012918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470012919 DNA binding residues [nucleotide binding] 446470012920 dimerization interface [polypeptide binding]; other site 446470012921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470012922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470012923 active site 446470012924 phosphorylation site [posttranslational modification] 446470012925 intermolecular recognition site; other site 446470012926 dimerization interface [polypeptide binding]; other site 446470012927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470012928 DNA binding site [nucleotide binding] 446470012929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470012930 dimerization interface [polypeptide binding]; other site 446470012931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470012932 dimer interface [polypeptide binding]; other site 446470012933 phosphorylation site [posttranslational modification] 446470012934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470012935 ATP binding site [chemical binding]; other site 446470012936 G-X-G motif; other site 446470012937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470012938 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446470012939 Peptidase family M48; Region: Peptidase_M48; cl12018 446470012940 YacP-like NYN domain; Region: NYN_YacP; cl01491 446470012941 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446470012942 GAF domain; Region: GAF; pfam01590 446470012943 GAF domain; Region: GAF_2; pfam13185 446470012944 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446470012945 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446470012946 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 446470012947 putative di-iron ligands [ion binding]; other site 446470012948 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470012949 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446470012950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470012951 Walker A/P-loop; other site 446470012952 ATP binding site [chemical binding]; other site 446470012953 Q-loop/lid; other site 446470012954 ABC transporter signature motif; other site 446470012955 Walker B; other site 446470012956 D-loop; other site 446470012957 H-loop/switch region; other site 446470012958 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446470012959 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 446470012960 putative sugar binding site [chemical binding]; other site 446470012961 catalytic residues [active] 446470012962 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 446470012963 P-loop; other site 446470012964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446470012965 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446470012966 substrate binding pocket [chemical binding]; other site 446470012967 membrane-bound complex binding site; other site 446470012968 hinge residues; other site 446470012969 lipoate-protein ligase B; Provisional; Region: PRK14345 446470012970 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 446470012971 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 446470012972 Dimer interface [polypeptide binding]; other site 446470012973 anticodon binding site; other site 446470012974 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470012975 motif 1; other site 446470012976 dimer interface [polypeptide binding]; other site 446470012977 active site 446470012978 motif 2; other site 446470012979 motif 3; other site 446470012980 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 446470012981 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 446470012982 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 446470012983 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 446470012984 protein binding site [polypeptide binding]; other site 446470012985 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 446470012986 Domain interface; other site 446470012987 Peptide binding site; other site 446470012988 Active site tetrad [active] 446470012989 lipoyl synthase; Provisional; Region: PRK05481 446470012990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470012991 FeS/SAM binding site; other site 446470012992 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 446470012993 RDD family; Region: RDD; pfam06271 446470012994 glutamine synthetase, type I; Region: GlnA; TIGR00653 446470012995 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446470012996 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446470012997 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 446470012998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470012999 metal binding site [ion binding]; metal-binding site 446470013000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470013001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470013002 dimerization interface [polypeptide binding]; other site 446470013003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470013004 dimer interface [polypeptide binding]; other site 446470013005 phosphorylation site [posttranslational modification] 446470013006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470013007 ATP binding site [chemical binding]; other site 446470013008 Mg2+ binding site [ion binding]; other site 446470013009 G-X-G motif; other site 446470013010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470013011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470013012 active site 446470013013 phosphorylation site [posttranslational modification] 446470013014 intermolecular recognition site; other site 446470013015 dimerization interface [polypeptide binding]; other site 446470013016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470013017 DNA binding site [nucleotide binding] 446470013018 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446470013019 putative metal binding residues [ion binding]; other site 446470013020 signature motif; other site 446470013021 dimer interface [polypeptide binding]; other site 446470013022 active site 446470013023 polyP binding site; other site 446470013024 substrate binding site [chemical binding]; other site 446470013025 acceptor-phosphate pocket; other site 446470013026 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446470013027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013028 putative substrate translocation pore; other site 446470013029 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446470013030 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446470013031 metal binding triad; other site 446470013032 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446470013033 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446470013034 metal binding triad; other site 446470013035 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446470013036 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470013037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470013038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470013039 non-specific DNA binding site [nucleotide binding]; other site 446470013040 salt bridge; other site 446470013041 sequence-specific DNA binding site [nucleotide binding]; other site 446470013042 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 446470013043 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446470013044 conserved cys residue [active] 446470013045 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446470013046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470013047 putative active site [active] 446470013048 putative metal binding site [ion binding]; other site 446470013049 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 446470013050 dimer interface [polypeptide binding]; other site 446470013051 catalytic triad [active] 446470013052 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 446470013053 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 446470013054 HIGH motif; other site 446470013055 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446470013056 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470013057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470013058 active site 446470013059 KMSKS motif; other site 446470013060 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446470013061 tRNA binding surface [nucleotide binding]; other site 446470013062 MoxR-like ATPases [General function prediction only]; Region: COG0714 446470013063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470013064 Walker A motif; other site 446470013065 ATP binding site [chemical binding]; other site 446470013066 Walker B motif; other site 446470013067 arginine finger; other site 446470013068 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446470013069 Protein of unknown function DUF58; Region: DUF58; pfam01882 446470013070 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446470013071 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446470013072 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446470013073 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446470013074 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 446470013075 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446470013076 DNA polymerase IV; Validated; Region: PRK03858 446470013077 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446470013078 active site 446470013079 DNA binding site [nucleotide binding] 446470013080 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446470013081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470013082 dimerization interface [polypeptide binding]; other site 446470013083 putative DNA binding site [nucleotide binding]; other site 446470013084 putative Zn2+ binding site [ion binding]; other site 446470013085 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470013086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470013087 S-adenosylmethionine binding site [chemical binding]; other site 446470013088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470013089 S-adenosylmethionine binding site [chemical binding]; other site 446470013090 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 446470013091 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446470013092 PQQ-like domain; Region: PQQ_2; pfam13360 446470013093 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 446470013094 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470013095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470013096 catalytic residue [active] 446470013097 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446470013098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446470013099 RNA binding surface [nucleotide binding]; other site 446470013100 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470013101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470013102 putative acyl-acceptor binding pocket; other site 446470013103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470013104 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470013105 catalytic site [active] 446470013106 proline/glycine betaine transporter; Provisional; Region: PRK10642 446470013107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013108 putative substrate translocation pore; other site 446470013109 EamA-like transporter family; Region: EamA; pfam00892 446470013110 MarR family; Region: MarR_2; cl17246 446470013111 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470013112 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446470013113 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446470013114 catalytic triad [active] 446470013115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470013116 Histidine kinase; Region: HisKA_3; pfam07730 446470013117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470013118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470013119 active site 446470013120 phosphorylation site [posttranslational modification] 446470013121 intermolecular recognition site; other site 446470013122 dimerization interface [polypeptide binding]; other site 446470013123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470013124 DNA binding residues [nucleotide binding] 446470013125 dimerization interface [polypeptide binding]; other site 446470013126 Short C-terminal domain; Region: SHOCT; pfam09851 446470013127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470013129 putative substrate translocation pore; other site 446470013130 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446470013131 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446470013132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470013133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470013134 homodimer interface [polypeptide binding]; other site 446470013135 catalytic residue [active] 446470013136 putative DNA binding site [nucleotide binding]; other site 446470013137 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446470013138 dimerization interface [polypeptide binding]; other site 446470013139 putative Zn2+ binding site [ion binding]; other site 446470013140 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470013141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470013142 nucleotide binding site [chemical binding]; other site 446470013143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013144 NAD synthetase; Provisional; Region: PRK13981 446470013145 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446470013146 multimer interface [polypeptide binding]; other site 446470013147 active site 446470013148 catalytic triad [active] 446470013149 protein interface 1 [polypeptide binding]; other site 446470013150 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446470013151 homodimer interface [polypeptide binding]; other site 446470013152 NAD binding pocket [chemical binding]; other site 446470013153 ATP binding pocket [chemical binding]; other site 446470013154 Mg binding site [ion binding]; other site 446470013155 active-site loop [active] 446470013156 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470013157 TIGR03086 family protein; Region: TIGR03086 446470013158 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 446470013159 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 446470013160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470013161 dimer interface [polypeptide binding]; other site 446470013162 conserved gate region; other site 446470013163 putative PBP binding loops; other site 446470013164 ABC-ATPase subunit interface; other site 446470013165 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 446470013166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470013167 dimer interface [polypeptide binding]; other site 446470013168 conserved gate region; other site 446470013169 putative PBP binding loops; other site 446470013170 ABC-ATPase subunit interface; other site 446470013171 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 446470013172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470013173 Walker A/P-loop; other site 446470013174 ATP binding site [chemical binding]; other site 446470013175 Q-loop/lid; other site 446470013176 ABC transporter signature motif; other site 446470013177 Walker B; other site 446470013178 D-loop; other site 446470013179 H-loop/switch region; other site 446470013180 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 446470013181 hypothetical protein; Provisional; Region: PRK10621 446470013182 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446470013183 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 446470013184 putative dimer interface [polypeptide binding]; other site 446470013185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470013186 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470013187 DNA binding site [nucleotide binding] 446470013188 Bacterial transcriptional activator domain; Region: BTAD; smart01043 446470013189 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470013190 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 446470013191 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 446470013192 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446470013193 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470013194 inhibitor-cofactor binding pocket; inhibition site 446470013195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470013196 catalytic residue [active] 446470013197 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446470013198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470013199 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446470013200 hydrophobic ligand binding site; other site 446470013201 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446470013202 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446470013203 active site 446470013204 FMN binding site [chemical binding]; other site 446470013205 substrate binding site [chemical binding]; other site 446470013206 homotetramer interface [polypeptide binding]; other site 446470013207 catalytic residue [active] 446470013208 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446470013209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013210 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446470013211 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446470013212 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446470013213 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470013214 ligand binding site [chemical binding]; other site 446470013215 flexible hinge region; other site 446470013216 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446470013217 putative switch regulator; other site 446470013218 non-specific DNA interactions [nucleotide binding]; other site 446470013219 DNA binding site [nucleotide binding] 446470013220 sequence specific DNA binding site [nucleotide binding]; other site 446470013221 putative cAMP binding site [chemical binding]; other site 446470013222 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470013223 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470013224 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470013225 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446470013226 classical (c) SDRs; Region: SDR_c; cd05233 446470013227 NAD(P) binding site [chemical binding]; other site 446470013228 active site 446470013229 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446470013230 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446470013231 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470013232 active site 446470013233 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470013234 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470013235 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446470013236 AAA domain; Region: AAA_17; pfam13207 446470013237 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446470013238 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446470013239 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446470013240 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446470013241 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446470013242 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446470013243 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470013244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470013245 putative acyl-acceptor binding pocket; other site 446470013246 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446470013247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013248 putative substrate translocation pore; other site 446470013249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013252 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446470013253 active site 446470013254 Ap6A binding site [chemical binding]; other site 446470013255 nudix motif; other site 446470013256 metal binding site [ion binding]; metal-binding site 446470013257 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446470013258 catalytic core [active] 446470013259 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446470013260 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446470013261 Mg++ binding site [ion binding]; other site 446470013262 putative catalytic motif [active] 446470013263 putative substrate binding site [chemical binding]; other site 446470013264 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 446470013265 IHF dimer interface [polypeptide binding]; other site 446470013266 IHF - DNA interface [nucleotide binding]; other site 446470013267 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 446470013268 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 446470013269 substrate binding site [chemical binding]; other site 446470013270 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446470013271 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446470013272 substrate binding site [chemical binding]; other site 446470013273 ligand binding site [chemical binding]; other site 446470013274 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446470013275 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446470013276 Bacterial transcriptional regulator; Region: IclR; pfam01614 446470013277 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 446470013278 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 446470013279 Cysteine-rich domain; Region: CCG; pfam02754 446470013280 Cysteine-rich domain; Region: CCG; pfam02754 446470013281 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446470013282 FAD binding domain; Region: FAD_binding_4; pfam01565 446470013283 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 446470013284 FAD binding domain; Region: FAD_binding_4; pfam01565 446470013285 malate synthase A; Region: malate_syn_A; TIGR01344 446470013286 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446470013287 active site 446470013288 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446470013289 FAD binding domain; Region: FAD_binding_4; pfam01565 446470013290 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 446470013291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470013292 S-adenosylmethionine binding site [chemical binding]; other site 446470013293 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446470013294 Bacterial SH3 domain; Region: SH3_3; pfam08239 446470013295 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446470013296 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446470013297 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446470013298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470013299 NAD(P) binding site [chemical binding]; other site 446470013300 active site 446470013301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470013302 Serine hydrolase; Region: Ser_hydrolase; cl17834 446470013303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470013304 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446470013305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013306 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 446470013307 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 446470013308 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470013309 cleavage site 446470013310 active site 446470013311 substrate binding sites [chemical binding]; other site 446470013312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470013313 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446470013314 Walker A motif; other site 446470013315 ATP binding site [chemical binding]; other site 446470013316 arginine finger; other site 446470013317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470013318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470013319 DNA binding residues [nucleotide binding] 446470013320 dimerization interface [polypeptide binding]; other site 446470013321 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470013322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470013323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470013324 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470013325 dimerization interface [polypeptide binding]; other site 446470013326 substrate binding pocket [chemical binding]; other site 446470013327 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446470013328 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 446470013329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470013330 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 446470013331 putative dimerization interface [polypeptide binding]; other site 446470013332 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 446470013333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470013334 binding surface 446470013335 TPR motif; other site 446470013336 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 446470013337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470013338 TPR motif; other site 446470013339 binding surface 446470013340 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 446470013341 FAD binding site [chemical binding]; other site 446470013342 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446470013343 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446470013344 substrate binding pocket [chemical binding]; other site 446470013345 chain length determination region; other site 446470013346 substrate-Mg2+ binding site; other site 446470013347 catalytic residues [active] 446470013348 aspartate-rich region 1; other site 446470013349 active site lid residues [active] 446470013350 aspartate-rich region 2; other site 446470013351 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 446470013352 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470013353 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470013354 active site 446470013355 ATP binding site [chemical binding]; other site 446470013356 substrate binding site [chemical binding]; other site 446470013357 activation loop (A-loop); other site 446470013358 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 446470013359 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 446470013360 heme binding site [chemical binding]; other site 446470013361 ferroxidase pore; other site 446470013362 ferroxidase diiron center [ion binding]; other site 446470013363 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446470013364 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470013365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470013366 Walker A/P-loop; other site 446470013367 ATP binding site [chemical binding]; other site 446470013368 Q-loop/lid; other site 446470013369 ABC transporter signature motif; other site 446470013370 Walker B; other site 446470013371 D-loop; other site 446470013372 H-loop/switch region; other site 446470013373 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446470013374 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446470013375 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 446470013376 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 446470013377 tetramer interface [polypeptide binding]; other site 446470013378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470013379 catalytic residue [active] 446470013380 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 446470013381 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 446470013382 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 446470013383 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446470013384 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446470013385 homodimer interface [polypeptide binding]; other site 446470013386 NADP binding site [chemical binding]; other site 446470013387 substrate binding site [chemical binding]; other site 446470013388 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 446470013389 active site 446470013390 8-oxo-dGMP binding site [chemical binding]; other site 446470013391 nudix motif; other site 446470013392 metal binding site [ion binding]; metal-binding site 446470013393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470013394 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470013395 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 446470013396 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 446470013397 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 446470013398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470013399 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446470013400 NAD(P) binding site [chemical binding]; other site 446470013401 active site 446470013402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470013405 nudix motif; other site 446470013406 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 446470013407 phosphofructokinase; Region: PFK_mixed; TIGR02483 446470013408 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 446470013409 active site 446470013410 ADP/pyrophosphate binding site [chemical binding]; other site 446470013411 dimerization interface [polypeptide binding]; other site 446470013412 allosteric effector site; other site 446470013413 fructose-1,6-bisphosphate binding site; other site 446470013414 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446470013415 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 446470013416 ligand binding site [chemical binding]; other site 446470013417 flexible hinge region; other site 446470013418 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446470013419 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446470013420 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 446470013421 active site 446470013422 PHP Thumb interface [polypeptide binding]; other site 446470013423 metal binding site [ion binding]; metal-binding site 446470013424 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446470013425 generic binding surface II; other site 446470013426 generic binding surface I; other site 446470013427 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446470013428 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446470013429 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470013430 classical (c) SDRs; Region: SDR_c; cd05233 446470013431 NAD(P) binding site [chemical binding]; other site 446470013432 active site 446470013433 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446470013434 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446470013435 metal binding site [ion binding]; metal-binding site 446470013436 substrate binding pocket [chemical binding]; other site 446470013437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013438 D-galactonate transporter; Region: 2A0114; TIGR00893 446470013439 putative substrate translocation pore; other site 446470013440 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446470013441 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446470013442 Bacterial transcriptional regulator; Region: IclR; pfam01614 446470013443 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 446470013444 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 446470013445 THF binding site; other site 446470013446 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446470013447 substrate binding site [chemical binding]; other site 446470013448 THF binding site; other site 446470013449 zinc-binding site [ion binding]; other site 446470013450 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446470013451 active sites [active] 446470013452 tetramer interface [polypeptide binding]; other site 446470013453 phosphoenolpyruvate synthase; Validated; Region: PRK06241 446470013454 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446470013455 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446470013456 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 446470013457 active site 446470013458 catalytic residues [active] 446470013459 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470013460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470013461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470013462 MarR family; Region: MarR; pfam01047 446470013463 MarR family; Region: MarR_2; cl17246 446470013464 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446470013465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470013466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470013467 active site 446470013468 phosphorylation site [posttranslational modification] 446470013469 intermolecular recognition site; other site 446470013470 dimerization interface [polypeptide binding]; other site 446470013471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470013472 DNA binding residues [nucleotide binding] 446470013473 dimerization interface [polypeptide binding]; other site 446470013474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470013475 Histidine kinase; Region: HisKA_3; pfam07730 446470013476 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470013477 Uncharacterized conserved protein [Function unknown]; Region: COG3402 446470013478 Bacterial PH domain; Region: DUF304; pfam03703 446470013479 Bacterial PH domain; Region: DUF304; cl01348 446470013480 Bacterial PH domain; Region: DUF304; pfam03703 446470013481 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470013482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470013483 active site 446470013484 catalytic tetrad [active] 446470013485 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 446470013486 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446470013487 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470013488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013490 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 446470013491 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446470013492 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 446470013493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470013494 S-adenosylmethionine binding site [chemical binding]; other site 446470013495 Protein of unknown function (DUF419); Region: DUF419; pfam04237 446470013496 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470013497 Cytochrome P450; Region: p450; cl12078 446470013498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470013501 Serine hydrolase; Region: Ser_hydrolase; cl17834 446470013502 Right handed beta helix region; Region: Beta_helix; pfam13229 446470013503 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 446470013504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013505 metabolite-proton symporter; Region: 2A0106; TIGR00883 446470013506 putative substrate translocation pore; other site 446470013507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013509 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 446470013510 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446470013511 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446470013512 shikimate binding site; other site 446470013513 NAD(P) binding site [chemical binding]; other site 446470013514 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446470013515 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 446470013516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470013517 active site 446470013518 metal binding site [ion binding]; metal-binding site 446470013519 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470013520 active site 446470013521 metal binding site [ion binding]; metal-binding site 446470013522 Right handed beta helix region; Region: Beta_helix; pfam13229 446470013523 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 446470013524 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470013525 DNA binding residues [nucleotide binding] 446470013526 hypothetical protein; Validated; Region: PRK02101 446470013527 Ion transport protein; Region: Ion_trans; pfam00520 446470013528 DMPK coiled coil domain like; Region: DMPK_coil; pfam08826 446470013529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470013530 Coenzyme A binding pocket [chemical binding]; other site 446470013531 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470013532 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446470013533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470013534 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470013535 Walker A/P-loop; other site 446470013536 ATP binding site [chemical binding]; other site 446470013537 Q-loop/lid; other site 446470013538 ABC transporter signature motif; other site 446470013539 Walker B; other site 446470013540 D-loop; other site 446470013541 H-loop/switch region; other site 446470013542 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446470013543 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446470013544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013545 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470013546 Phosphotransferase enzyme family; Region: APH; pfam01636 446470013547 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470013548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013549 putative substrate translocation pore; other site 446470013550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470013551 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470013552 active site 446470013553 metal binding site [ion binding]; metal-binding site 446470013554 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446470013555 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 446470013556 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446470013557 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446470013558 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446470013559 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446470013560 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446470013561 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 446470013562 oligomer interface [polypeptide binding]; other site 446470013563 RNA binding site [nucleotide binding]; other site 446470013564 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446470013565 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 446470013566 RNase E interface [polypeptide binding]; other site 446470013567 trimer interface [polypeptide binding]; other site 446470013568 active site 446470013569 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446470013570 putative nucleic acid binding region [nucleotide binding]; other site 446470013571 G-X-X-G motif; other site 446470013572 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 446470013573 RNA binding site [nucleotide binding]; other site 446470013574 domain interface; other site 446470013575 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 446470013576 16S/18S rRNA binding site [nucleotide binding]; other site 446470013577 S13e-L30e interaction site [polypeptide binding]; other site 446470013578 25S rRNA binding site [nucleotide binding]; other site 446470013579 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446470013580 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446470013581 active site 446470013582 Riboflavin kinase; Region: Flavokinase; pfam01687 446470013583 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446470013584 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 446470013585 RNA binding site [nucleotide binding]; other site 446470013586 active site 446470013587 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446470013588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446470013589 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446470013590 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 446470013591 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446470013592 active site 446470013593 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 446470013594 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 446470013595 putative substrate binding region [chemical binding]; other site 446470013596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446470013597 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446470013598 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446470013599 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 446470013600 PgaD-like protein; Region: PgaD; cl14676 446470013601 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470013602 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446470013603 Walker A/P-loop; other site 446470013604 ATP binding site [chemical binding]; other site 446470013605 Q-loop/lid; other site 446470013606 ABC transporter signature motif; other site 446470013607 Walker B; other site 446470013608 D-loop; other site 446470013609 H-loop/switch region; other site 446470013610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 446470013611 Endonuclease I; Region: Endonuclease_1; pfam04231 446470013612 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 446470013613 MMPL family; Region: MMPL; pfam03176 446470013614 MMPL family; Region: MMPL; pfam03176 446470013615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013617 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470013618 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470013619 active site 446470013620 ATP binding site [chemical binding]; other site 446470013621 substrate binding site [chemical binding]; other site 446470013622 activation loop (A-loop); other site 446470013623 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470013624 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470013625 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446470013626 Walker A/P-loop; other site 446470013627 ATP binding site [chemical binding]; other site 446470013628 Q-loop/lid; other site 446470013629 ABC transporter signature motif; other site 446470013630 Walker B; other site 446470013631 D-loop; other site 446470013632 H-loop/switch region; other site 446470013633 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446470013634 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446470013635 Predicted methyltransferases [General function prediction only]; Region: COG0313 446470013636 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 446470013637 putative SAM binding site [chemical binding]; other site 446470013638 putative homodimer interface [polypeptide binding]; other site 446470013639 Restriction endonuclease; Region: Mrr_cat; pfam04471 446470013640 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470013641 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470013642 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446470013643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470013644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470013645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470013646 Coenzyme A binding pocket [chemical binding]; other site 446470013647 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 446470013648 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 446470013649 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 446470013650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 446470013651 Beta-Casp domain; Region: Beta-Casp; pfam10996 446470013652 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446470013653 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470013654 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446470013655 protein binding site [polypeptide binding]; other site 446470013656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470013657 dimerization interface [polypeptide binding]; other site 446470013658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470013659 dimer interface [polypeptide binding]; other site 446470013660 phosphorylation site [posttranslational modification] 446470013661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470013662 ATP binding site [chemical binding]; other site 446470013663 Mg2+ binding site [ion binding]; other site 446470013664 G-X-G motif; other site 446470013665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470013666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470013667 active site 446470013668 phosphorylation site [posttranslational modification] 446470013669 intermolecular recognition site; other site 446470013670 dimerization interface [polypeptide binding]; other site 446470013671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470013672 DNA binding site [nucleotide binding] 446470013673 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446470013674 anti sigma factor interaction site; other site 446470013675 regulatory phosphorylation site [posttranslational modification]; other site 446470013676 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446470013677 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446470013678 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 446470013679 TPP-binding site [chemical binding]; other site 446470013680 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 446470013681 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446470013682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446470013683 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446470013684 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470013685 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470013686 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470013687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470013688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470013689 DNA binding residues [nucleotide binding] 446470013690 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 446470013691 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 446470013692 gating phenylalanine in ion channel; other site 446470013693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470013694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470013695 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 446470013696 putative dimerization interface [polypeptide binding]; other site 446470013697 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446470013698 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446470013699 NAD(P) binding site [chemical binding]; other site 446470013700 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 446470013701 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 446470013702 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446470013703 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446470013704 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 446470013705 NAD(P) binding pocket [chemical binding]; other site 446470013706 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 446470013707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446470013708 Transcription factor WhiB; Region: Whib; pfam02467 446470013709 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446470013710 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446470013711 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446470013712 putative active site [active] 446470013713 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446470013714 active site 446470013715 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 446470013716 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446470013717 Active Sites [active] 446470013718 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 446470013719 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 446470013720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446470013721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446470013722 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446470013723 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 446470013724 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446470013725 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 446470013726 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 446470013727 putative active site [active] 446470013728 putative dimer interface [polypeptide binding]; other site 446470013729 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 446470013730 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 446470013731 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446470013732 catalytic core [active] 446470013733 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 446470013734 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 446470013735 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 446470013736 YhhN-like protein; Region: YhhN; pfam07947 446470013737 Restriction endonuclease; Region: Mrr_cat; pfam04471 446470013738 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446470013739 PAS fold; Region: PAS_4; pfam08448 446470013740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446470013741 Histidine kinase; Region: HisKA_2; pfam07568 446470013742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470013743 ATP binding site [chemical binding]; other site 446470013744 Mg2+ binding site [ion binding]; other site 446470013745 G-X-G motif; other site 446470013746 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446470013747 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 446470013748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470013749 dimer interface [polypeptide binding]; other site 446470013750 conserved gate region; other site 446470013751 ABC-ATPase subunit interface; other site 446470013752 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446470013753 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 446470013754 Walker A/P-loop; other site 446470013755 ATP binding site [chemical binding]; other site 446470013756 Q-loop/lid; other site 446470013757 ABC transporter signature motif; other site 446470013758 Walker B; other site 446470013759 D-loop; other site 446470013760 H-loop/switch region; other site 446470013761 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446470013762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470013763 dimer interface [polypeptide binding]; other site 446470013764 conserved gate region; other site 446470013765 putative PBP binding loops; other site 446470013766 ABC-ATPase subunit interface; other site 446470013767 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 446470013768 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446470013769 dimer interface [polypeptide binding]; other site 446470013770 active site 446470013771 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446470013772 dimer interface [polypeptide binding]; other site 446470013773 active site 446470013774 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446470013775 carboxyltransferase (CT) interaction site; other site 446470013776 biotinylation site [posttranslational modification]; other site 446470013777 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470013778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013779 putative substrate translocation pore; other site 446470013780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013783 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 446470013784 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446470013785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470013786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470013787 DNA binding residues [nucleotide binding] 446470013788 Transcription factor WhiB; Region: Whib; pfam02467 446470013789 Uncharacterized conserved protein [Function unknown]; Region: COG2135 446470013790 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 446470013791 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 446470013792 hinge; other site 446470013793 active site 446470013794 Predicted GTPases [General function prediction only]; Region: COG1162 446470013795 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446470013796 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446470013797 GTP/Mg2+ binding site [chemical binding]; other site 446470013798 G4 box; other site 446470013799 G5 box; other site 446470013800 G1 box; other site 446470013801 Switch I region; other site 446470013802 G2 box; other site 446470013803 G3 box; other site 446470013804 Switch II region; other site 446470013805 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446470013806 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446470013807 active site 446470013808 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 446470013809 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470013810 putative catalytic site [active] 446470013811 putative metal binding site [ion binding]; other site 446470013812 putative phosphate binding site [ion binding]; other site 446470013813 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 446470013814 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446470013815 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446470013816 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 446470013817 putative active site [active] 446470013818 putative substrate binding site [chemical binding]; other site 446470013819 putative cosubstrate binding site; other site 446470013820 catalytic site [active] 446470013821 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470013822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470013823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470013824 DNA binding residues [nucleotide binding] 446470013825 YCII-related domain; Region: YCII; cl00999 446470013826 YCII-related domain; Region: YCII; cl00999 446470013827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470013828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470013829 active site 446470013830 ATP binding site [chemical binding]; other site 446470013831 substrate binding site [chemical binding]; other site 446470013832 activation loop (A-loop); other site 446470013833 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470013834 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470013835 structural tetrad; other site 446470013836 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470013837 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470013838 active site 446470013839 ATP binding site [chemical binding]; other site 446470013840 substrate binding site [chemical binding]; other site 446470013841 activation loop (A-loop); other site 446470013842 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470013843 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446470013844 structural tetrad; other site 446470013845 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 446470013846 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 446470013847 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 446470013848 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 446470013849 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 446470013850 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 446470013851 [4Fe-4S] binding site [ion binding]; other site 446470013852 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446470013853 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446470013854 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446470013855 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 446470013856 molybdopterin cofactor binding site; other site 446470013857 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 446470013858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013859 putative substrate translocation pore; other site 446470013860 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470013861 Ligand Binding Site [chemical binding]; other site 446470013862 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446470013863 Ligand Binding Site [chemical binding]; other site 446470013864 benzoate transport; Region: 2A0115; TIGR00895 446470013865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470013866 putative substrate translocation pore; other site 446470013867 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470013868 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 446470013869 active site 446470013870 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 446470013871 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 446470013872 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 446470013873 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 446470013874 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 446470013875 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446470013876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470013877 DNA-binding site [nucleotide binding]; DNA binding site 446470013878 FCD domain; Region: FCD; pfam07729 446470013879 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 446470013880 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446470013881 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 446470013882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470013883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446470013884 dimerization interface [polypeptide binding]; other site 446470013885 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 446470013886 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 446470013887 putative Iron-sulfur protein interface [polypeptide binding]; other site 446470013888 proximal heme binding site [chemical binding]; other site 446470013889 distal heme binding site [chemical binding]; other site 446470013890 putative dimer interface [polypeptide binding]; other site 446470013891 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 446470013892 L-aspartate oxidase; Provisional; Region: PRK06175 446470013893 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446470013894 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 446470013895 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446470013896 4Fe-4S binding domain; Region: Fer4; pfam00037 446470013897 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 446470013898 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 446470013899 [2Fe-2S] cluster binding site [ion binding]; other site 446470013900 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446470013901 hydrophobic ligand binding site; other site 446470013902 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446470013903 CoenzymeA binding site [chemical binding]; other site 446470013904 subunit interaction site [polypeptide binding]; other site 446470013905 PHB binding site; other site 446470013906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470013907 Serine hydrolase; Region: Ser_hydrolase; cl17834 446470013908 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470013909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470013910 non-specific DNA binding site [nucleotide binding]; other site 446470013911 salt bridge; other site 446470013912 sequence-specific DNA binding site [nucleotide binding]; other site 446470013913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470013914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470013915 DNA binding residues [nucleotide binding] 446470013916 dimerization interface [polypeptide binding]; other site 446470013917 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446470013918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470013919 dimerization interface [polypeptide binding]; other site 446470013920 putative DNA binding site [nucleotide binding]; other site 446470013921 putative Zn2+ binding site [ion binding]; other site 446470013922 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 446470013923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470013924 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470013925 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470013926 active site 446470013927 ATP binding site [chemical binding]; other site 446470013928 substrate binding site [chemical binding]; other site 446470013929 activation loop (A-loop); other site 446470013930 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 446470013931 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470013932 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470013933 active site 446470013934 ATP binding site [chemical binding]; other site 446470013935 substrate binding site [chemical binding]; other site 446470013936 activation loop (A-loop); other site 446470013937 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 446470013938 putative active site [active] 446470013939 Zn binding site [ion binding]; other site 446470013940 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 446470013941 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446470013942 conserved cys residue [active] 446470013943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470013944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470013945 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 446470013946 Isochorismatase family; Region: Isochorismatase; pfam00857 446470013947 catalytic triad [active] 446470013948 conserved cis-peptide bond; other site 446470013949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470013950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470013951 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470013952 cleavage site 446470013953 active site 446470013954 substrate binding sites [chemical binding]; other site 446470013955 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446470013956 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 446470013957 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446470013958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446470013959 active site 446470013960 Predicted membrane protein [Function unknown]; Region: COG2246 446470013961 GtrA-like protein; Region: GtrA; pfam04138 446470013962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470013963 dimer interface [polypeptide binding]; other site 446470013964 phosphorylation site [posttranslational modification] 446470013965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470013966 ATP binding site [chemical binding]; other site 446470013967 Mg2+ binding site [ion binding]; other site 446470013968 G-X-G motif; other site 446470013969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470013970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470013971 active site 446470013972 phosphorylation site [posttranslational modification] 446470013973 intermolecular recognition site; other site 446470013974 dimerization interface [polypeptide binding]; other site 446470013975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470013976 DNA binding site [nucleotide binding] 446470013977 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 446470013978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446470013979 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446470013980 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470013981 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 446470013982 active site 446470013983 thiamine phosphate binding site [chemical binding]; other site 446470013984 pyrophosphate binding site [ion binding]; other site 446470013985 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470013986 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470013987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446470013988 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446470013989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470013990 NmrA-like family; Region: NmrA; pfam05368 446470013991 NAD(P) binding site [chemical binding]; other site 446470013992 active site 446470013993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470013994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470013995 active site 446470013996 phosphorylation site [posttranslational modification] 446470013997 intermolecular recognition site; other site 446470013998 dimerization interface [polypeptide binding]; other site 446470013999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470014000 DNA binding residues [nucleotide binding] 446470014001 dimerization interface [polypeptide binding]; other site 446470014002 Phage shock protein B; Region: PspB; cl05946 446470014003 Histidine kinase; Region: HisKA_3; pfam07730 446470014004 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470014005 Histidine kinase; Region: HisKA_3; pfam07730 446470014006 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470014007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470014008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470014009 active site 446470014010 phosphorylation site [posttranslational modification] 446470014011 intermolecular recognition site; other site 446470014012 dimerization interface [polypeptide binding]; other site 446470014013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470014014 DNA binding residues [nucleotide binding] 446470014015 dimerization interface [polypeptide binding]; other site 446470014016 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470014017 putative catalytic site [active] 446470014018 putative phosphate binding site [ion binding]; other site 446470014019 putative metal binding site [ion binding]; other site 446470014020 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470014021 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446470014022 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446470014023 G1 box; other site 446470014024 GTP/Mg2+ binding site [chemical binding]; other site 446470014025 G2 box; other site 446470014026 Switch I region; other site 446470014027 G3 box; other site 446470014028 Switch II region; other site 446470014029 G4 box; other site 446470014030 G5 box; other site 446470014031 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446470014032 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446470014033 Nitrate and nitrite sensing; Region: NIT; pfam08376 446470014034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470014035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470014036 ATP binding site [chemical binding]; other site 446470014037 Mg2+ binding site [ion binding]; other site 446470014038 G-X-G motif; other site 446470014039 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 446470014040 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 446470014041 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 446470014042 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446470014043 amidase catalytic site [active] 446470014044 Zn binding residues [ion binding]; other site 446470014045 substrate binding site [chemical binding]; other site 446470014046 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 446470014047 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 446470014048 putative active site [active] 446470014049 putative dimer interface [polypeptide binding]; other site 446470014050 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470014051 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 446470014052 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470014053 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 446470014054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446470014055 nucleotide binding site [chemical binding]; other site 446470014056 Ycf46; Provisional; Region: ycf46; CHL00195 446470014057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470014058 Walker A motif; other site 446470014059 ATP binding site [chemical binding]; other site 446470014060 Walker B motif; other site 446470014061 arginine finger; other site 446470014062 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 446470014063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470014064 FeS/SAM binding site; other site 446470014065 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 446470014066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470014067 S-adenosylmethionine binding site [chemical binding]; other site 446470014068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470014069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470014070 non-specific DNA binding site [nucleotide binding]; other site 446470014071 salt bridge; other site 446470014072 sequence-specific DNA binding site [nucleotide binding]; other site 446470014073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470014074 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446470014075 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446470014076 DNA binding site [nucleotide binding] 446470014077 catalytic residue [active] 446470014078 H2TH interface [polypeptide binding]; other site 446470014079 putative catalytic residues [active] 446470014080 turnover-facilitating residue; other site 446470014081 intercalation triad [nucleotide binding]; other site 446470014082 8OG recognition residue [nucleotide binding]; other site 446470014083 putative reading head residues; other site 446470014084 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446470014085 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446470014086 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446470014087 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446470014088 sugar efflux transporter; Region: 2A0120; TIGR00899 446470014089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014090 putative substrate translocation pore; other site 446470014091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470014092 S-adenosylmethionine binding site [chemical binding]; other site 446470014093 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470014094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470014095 non-specific DNA binding site [nucleotide binding]; other site 446470014096 salt bridge; other site 446470014097 sequence-specific DNA binding site [nucleotide binding]; other site 446470014098 Cupin domain; Region: Cupin_2; cl17218 446470014099 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446470014100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470014101 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470014102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470014103 DNA-binding site [nucleotide binding]; DNA binding site 446470014104 FCD domain; Region: FCD; pfam07729 446470014105 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 446470014106 ATP-binding site [chemical binding]; other site 446470014107 Gluconate-6-phosphate binding site [chemical binding]; other site 446470014108 GntP family permease; Region: GntP_permease; pfam02447 446470014109 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446470014110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470014111 NAD(P) binding site [chemical binding]; other site 446470014112 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446470014113 active site 446470014114 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 446470014115 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470014116 active site 446470014117 metal binding site [ion binding]; metal-binding site 446470014118 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470014119 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470014120 active site 446470014121 ATP binding site [chemical binding]; other site 446470014122 substrate binding site [chemical binding]; other site 446470014123 activation loop (A-loop); other site 446470014124 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446470014125 PQQ-like domain; Region: PQQ_2; pfam13360 446470014126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470014127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470014128 active site 446470014129 ATP binding site [chemical binding]; other site 446470014130 substrate binding site [chemical binding]; other site 446470014131 activation loop (A-loop); other site 446470014132 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 446470014133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470014134 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470014135 Caspase domain; Region: Peptidase_C14; pfam00656 446470014136 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 446470014137 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470014138 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470014139 active site 446470014140 catalytic tetrad [active] 446470014141 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 446470014142 putative Zn2+ binding site [ion binding]; other site 446470014143 hydroperoxidase II; Provisional; Region: katE; PRK11249 446470014144 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 446470014145 tetramer interface [polypeptide binding]; other site 446470014146 heme binding pocket [chemical binding]; other site 446470014147 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 446470014148 domain interactions; other site 446470014149 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470014150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470014151 Coenzyme A binding pocket [chemical binding]; other site 446470014152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446470014153 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 446470014154 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 446470014155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014157 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470014158 Cytochrome P450; Region: p450; cl12078 446470014159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014161 hypothetical protein; Provisional; Region: PRK06753 446470014162 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470014163 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446470014164 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470014165 Cytochrome P450; Region: p450; cl12078 446470014166 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446470014167 MarR family; Region: MarR; pfam01047 446470014168 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 446470014169 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446470014170 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446470014171 NAD(P) binding site [chemical binding]; other site 446470014172 substrate binding site [chemical binding]; other site 446470014173 dimer interface [polypeptide binding]; other site 446470014174 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 446470014175 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 446470014176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014177 metabolite-proton symporter; Region: 2A0106; TIGR00883 446470014178 putative substrate translocation pore; other site 446470014179 GAF domain; Region: GAF_2; pfam13185 446470014180 GAF domain; Region: GAF; pfam01590 446470014181 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446470014182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470014183 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 446470014184 NAD(P) binding site [chemical binding]; other site 446470014185 active site 446470014186 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470014187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014189 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470014190 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470014191 Walker A/P-loop; other site 446470014192 ATP binding site [chemical binding]; other site 446470014193 Q-loop/lid; other site 446470014194 ABC transporter signature motif; other site 446470014195 Walker B; other site 446470014196 D-loop; other site 446470014197 H-loop/switch region; other site 446470014198 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470014199 ABC-ATPase subunit interface; other site 446470014200 dimer interface [polypeptide binding]; other site 446470014201 putative PBP binding regions; other site 446470014202 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446470014203 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470014204 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470014205 dimer interface [polypeptide binding]; other site 446470014206 putative PBP binding regions; other site 446470014207 ABC-ATPase subunit interface; other site 446470014208 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446470014209 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446470014210 siderophore binding site; other site 446470014211 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470014212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470014213 non-specific DNA binding site [nucleotide binding]; other site 446470014214 salt bridge; other site 446470014215 sequence-specific DNA binding site [nucleotide binding]; other site 446470014216 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 446470014217 Domain of unknown function (DUF955); Region: DUF955; cl01076 446470014218 isocitrate lyase; Provisional; Region: PRK15063 446470014219 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446470014220 tetramer interface [polypeptide binding]; other site 446470014221 active site 446470014222 Mg2+/Mn2+ binding site [ion binding]; other site 446470014223 malate synthase A; Region: malate_syn_A; TIGR01344 446470014224 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446470014225 active site 446470014226 hypothetical protein; Provisional; Region: PRK07588 446470014227 hypothetical protein; Provisional; Region: PRK07236 446470014228 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 446470014229 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 446470014230 generic binding surface I; other site 446470014231 generic binding surface II; other site 446470014232 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470014233 putative catalytic site [active] 446470014234 putative metal binding site [ion binding]; other site 446470014235 putative phosphate binding site [ion binding]; other site 446470014236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470014237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470014238 active site 446470014239 phosphorylation site [posttranslational modification] 446470014240 intermolecular recognition site; other site 446470014241 dimerization interface [polypeptide binding]; other site 446470014242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470014243 DNA binding site [nucleotide binding] 446470014244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470014245 dimerization interface [polypeptide binding]; other site 446470014246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470014247 dimer interface [polypeptide binding]; other site 446470014248 phosphorylation site [posttranslational modification] 446470014249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470014250 ATP binding site [chemical binding]; other site 446470014251 Mg2+ binding site [ion binding]; other site 446470014252 G-X-G motif; other site 446470014253 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446470014254 Peptidase family M28; Region: Peptidase_M28; pfam04389 446470014255 metal binding site [ion binding]; metal-binding site 446470014256 hypothetical protein; Provisional; Region: PRK01346 446470014257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470014258 Coenzyme A binding pocket [chemical binding]; other site 446470014259 AAA ATPase domain; Region: AAA_16; pfam13191 446470014260 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470014261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470014262 DNA binding residues [nucleotide binding] 446470014263 dimerization interface [polypeptide binding]; other site 446470014264 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 446470014265 Phosphotransferase enzyme family; Region: APH; pfam01636 446470014266 putative active site [active] 446470014267 putative substrate binding site [chemical binding]; other site 446470014268 ATP binding site [chemical binding]; other site 446470014269 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 446470014270 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446470014271 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446470014272 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446470014273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446470014274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446470014275 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 446470014276 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 446470014277 putative ligand binding site [chemical binding]; other site 446470014278 putative NAD binding site [chemical binding]; other site 446470014279 catalytic site [active] 446470014280 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 446470014281 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446470014282 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 446470014283 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 446470014284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470014285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470014286 Coenzyme A binding pocket [chemical binding]; other site 446470014287 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446470014288 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470014289 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470014290 AAA ATPase domain; Region: AAA_16; pfam13191 446470014291 NB-ARC domain; Region: NB-ARC; pfam00931 446470014292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470014293 TPR motif; other site 446470014294 binding surface 446470014295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470014296 binding surface 446470014297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470014298 TPR motif; other site 446470014299 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470014300 RibD C-terminal domain; Region: RibD_C; cl17279 446470014301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470014302 S-adenosylmethionine binding site [chemical binding]; other site 446470014303 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 446470014304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470014305 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470014306 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446470014307 DNA binding site [nucleotide binding] 446470014308 active site 446470014309 Int/Topo IB signature motif; other site 446470014310 catalytic residues [active] 446470014311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014312 dimerization interface [polypeptide binding]; other site 446470014313 putative DNA binding site [nucleotide binding]; other site 446470014314 putative Zn2+ binding site [ion binding]; other site 446470014315 mercuric reductase; Region: MerA; TIGR02053 446470014316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470014317 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446470014318 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470014319 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470014320 DNA binding residues [nucleotide binding] 446470014321 alkylmercury lyase; Provisional; Region: PRK13239 446470014322 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 446470014323 Alkylmercury lyase; Region: MerB; pfam03243 446470014324 Alkylmercury lyase; Region: MerB; pfam03243 446470014325 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446470014326 arsenical-resistance protein; Region: acr3; TIGR00832 446470014327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014328 dimerization interface [polypeptide binding]; other site 446470014329 putative DNA binding site [nucleotide binding]; other site 446470014330 putative Zn2+ binding site [ion binding]; other site 446470014331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014332 putative DNA binding site [nucleotide binding]; other site 446470014333 dimerization interface [polypeptide binding]; other site 446470014334 putative Zn2+ binding site [ion binding]; other site 446470014335 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446470014336 active site 446470014337 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446470014338 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446470014339 active site 446470014340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014341 dimerization interface [polypeptide binding]; other site 446470014342 putative DNA binding site [nucleotide binding]; other site 446470014343 putative Zn2+ binding site [ion binding]; other site 446470014344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446470014345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446470014346 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 446470014347 DNA binding residues [nucleotide binding] 446470014348 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 446470014349 dimer interface [polypeptide binding]; other site 446470014350 mercury binding site [ion binding]; other site 446470014351 hypothetical protein; Provisional; Region: PRK02237 446470014352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014353 dimerization interface [polypeptide binding]; other site 446470014354 putative DNA binding site [nucleotide binding]; other site 446470014355 putative Zn2+ binding site [ion binding]; other site 446470014356 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470014357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470014358 S-adenosylmethionine binding site [chemical binding]; other site 446470014359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470014360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014361 putative substrate translocation pore; other site 446470014362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446470014363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014364 dimerization interface [polypeptide binding]; other site 446470014365 putative DNA binding site [nucleotide binding]; other site 446470014366 putative Zn2+ binding site [ion binding]; other site 446470014367 mycothione reductase; Reviewed; Region: PRK07846 446470014368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470014369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470014370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446470014371 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 446470014372 Cation efflux family; Region: Cation_efflux; cl00316 446470014373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014374 dimerization interface [polypeptide binding]; other site 446470014375 putative DNA binding site [nucleotide binding]; other site 446470014376 putative Zn2+ binding site [ion binding]; other site 446470014377 Helix-turn-helix domain; Region: HTH_18; pfam12833 446470014378 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 446470014379 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 446470014380 TrwC relaxase; Region: TrwC; pfam08751 446470014381 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 446470014382 AAA domain; Region: AAA_30; pfam13604 446470014383 Family description; Region: UvrD_C_2; pfam13538 446470014384 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 446470014385 generic binding surface II; other site 446470014386 generic binding surface I; other site 446470014387 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 446470014388 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446470014389 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446470014390 dimer interface [polypeptide binding]; other site 446470014391 ssDNA binding site [nucleotide binding]; other site 446470014392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446470014393 DNA protecting protein DprA; Region: dprA; TIGR00732 446470014394 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446470014395 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446470014396 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446470014397 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 446470014398 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 446470014399 ParB-like nuclease domain; Region: ParB; smart00470 446470014400 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470014401 Helix-turn-helix domain; Region: HTH_31; pfam13560 446470014402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470014403 non-specific DNA binding site [nucleotide binding]; other site 446470014404 salt bridge; other site 446470014405 sequence-specific DNA binding site [nucleotide binding]; other site 446470014406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470014407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470014408 DNA binding residues [nucleotide binding] 446470014409 dimerization interface [polypeptide binding]; other site 446470014410 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 446470014411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470014412 S-adenosylmethionine binding site [chemical binding]; other site 446470014413 FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363 446470014414 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 446470014415 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 446470014416 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446470014417 active site 446470014418 zinc binding site [ion binding]; other site 446470014419 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446470014420 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446470014421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470014422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470014423 non-specific DNA binding site [nucleotide binding]; other site 446470014424 salt bridge; other site 446470014425 sequence-specific DNA binding site [nucleotide binding]; other site 446470014426 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 446470014427 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470014428 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470014429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470014430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446470014431 sequence-specific DNA binding site [nucleotide binding]; other site 446470014432 salt bridge; other site 446470014433 PrgI family protein; Region: PrgI; pfam12666 446470014434 AAA-like domain; Region: AAA_10; pfam12846 446470014435 AAA domain; Region: AAA_17; pfam13207 446470014436 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 446470014437 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 446470014438 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446470014439 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446470014440 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 446470014441 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470014442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470014443 active site 446470014444 ATP binding site [chemical binding]; other site 446470014445 substrate binding site [chemical binding]; other site 446470014446 activation loop (A-loop); other site 446470014447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470014448 active site 446470014449 ATP binding site [chemical binding]; other site 446470014450 substrate binding site [chemical binding]; other site 446470014451 activation loop (A-loop); other site 446470014452 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 446470014453 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 446470014454 Uncharacterized conserved protein [Function unknown]; Region: COG4198 446470014455 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446470014456 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446470014457 Zn binding site [ion binding]; other site 446470014458 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470014459 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 446470014460 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 446470014461 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 446470014462 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 446470014463 nucleotide binding site/active site [active] 446470014464 HIT family signature motif; other site 446470014465 catalytic residue [active] 446470014466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470014467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470014468 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 446470014469 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470014470 putative dimerization interface [polypeptide binding]; other site 446470014471 RibD C-terminal domain; Region: RibD_C; cl17279 446470014472 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 446470014473 chaperone protein DnaJ; Provisional; Region: PRK14278 446470014474 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446470014475 HSP70 interaction site [polypeptide binding]; other site 446470014476 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446470014477 Zn binding sites [ion binding]; other site 446470014478 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446470014479 dimer interface [polypeptide binding]; other site 446470014480 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446470014481 Tic20-like protein; Region: Tic20; pfam09685 446470014482 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446470014483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470014484 FeS/SAM binding site; other site 446470014485 enoyl-CoA hydratase; Provisional; Region: PRK07827 446470014486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470014487 substrate binding site [chemical binding]; other site 446470014488 oxyanion hole (OAH) forming residues; other site 446470014489 trimer interface [polypeptide binding]; other site 446470014490 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446470014491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014492 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470014493 putative substrate translocation pore; other site 446470014494 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470014495 HTH domain; Region: HTH_11; pfam08279 446470014496 WYL domain; Region: WYL; pfam13280 446470014497 GTP-binding protein LepA; Provisional; Region: PRK05433 446470014498 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 446470014499 G1 box; other site 446470014500 putative GEF interaction site [polypeptide binding]; other site 446470014501 GTP/Mg2+ binding site [chemical binding]; other site 446470014502 Switch I region; other site 446470014503 G2 box; other site 446470014504 G3 box; other site 446470014505 Switch II region; other site 446470014506 G4 box; other site 446470014507 G5 box; other site 446470014508 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 446470014509 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446470014510 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446470014511 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470014512 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 446470014513 hypothetical protein; Reviewed; Region: PRK07914 446470014514 hypothetical protein; Provisional; Region: PRK10621 446470014515 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446470014516 Competence protein; Region: Competence; pfam03772 446470014517 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 446470014518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470014519 SLBB domain; Region: SLBB; pfam10531 446470014520 comEA protein; Region: comE; TIGR01259 446470014521 Helix-hairpin-helix motif; Region: HHH; pfam00633 446470014522 EDD domain protein, DegV family; Region: DegV; TIGR00762 446470014523 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 446470014524 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446470014525 catalytic core [active] 446470014526 Oligomerisation domain; Region: Oligomerisation; cl00519 446470014527 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 446470014528 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446470014529 active site 446470014530 (T/H)XGH motif; other site 446470014531 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446470014532 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446470014533 Zn binding site [ion binding]; other site 446470014534 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446470014535 GTP1/OBG; Region: GTP1_OBG; pfam01018 446470014536 Obg GTPase; Region: Obg; cd01898 446470014537 G1 box; other site 446470014538 GTP/Mg2+ binding site [chemical binding]; other site 446470014539 Switch I region; other site 446470014540 G2 box; other site 446470014541 G3 box; other site 446470014542 Switch II region; other site 446470014543 G4 box; other site 446470014544 G5 box; other site 446470014545 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 446470014546 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 446470014547 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 446470014548 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 446470014549 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446470014550 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446470014551 homodimer interface [polypeptide binding]; other site 446470014552 oligonucleotide binding site [chemical binding]; other site 446470014553 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 446470014554 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 446470014555 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 446470014556 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446470014557 B12 binding site [chemical binding]; other site 446470014558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470014559 FeS/SAM binding site; other site 446470014560 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 446470014561 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446470014562 active site 446470014563 catalytic residues [active] 446470014564 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470014565 cleavage site 446470014566 active site 446470014567 substrate binding sites [chemical binding]; other site 446470014568 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470014569 active site 446470014570 substrate binding sites [chemical binding]; other site 446470014571 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 446470014572 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 446470014573 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446470014574 metal binding site [ion binding]; metal-binding site 446470014575 putative dimer interface [polypeptide binding]; other site 446470014576 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 446470014577 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 446470014578 putative trimer interface [polypeptide binding]; other site 446470014579 putative CoA binding site [chemical binding]; other site 446470014580 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 446470014581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470014582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470014583 homodimer interface [polypeptide binding]; other site 446470014584 catalytic residue [active] 446470014585 Ferredoxin [Energy production and conversion]; Region: COG1146 446470014586 4Fe-4S binding domain; Region: Fer4; pfam00037 446470014587 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 446470014588 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446470014589 peptide binding site [polypeptide binding]; other site 446470014590 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446470014591 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 446470014592 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470014593 Walker A/P-loop; other site 446470014594 ATP binding site [chemical binding]; other site 446470014595 Q-loop/lid; other site 446470014596 ABC transporter signature motif; other site 446470014597 Walker B; other site 446470014598 D-loop; other site 446470014599 H-loop/switch region; other site 446470014600 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446470014601 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470014602 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470014603 Walker A/P-loop; other site 446470014604 ATP binding site [chemical binding]; other site 446470014605 Q-loop/lid; other site 446470014606 ABC transporter signature motif; other site 446470014607 Walker B; other site 446470014608 D-loop; other site 446470014609 H-loop/switch region; other site 446470014610 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446470014611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470014612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470014613 putative PBP binding loops; other site 446470014614 dimer interface [polypeptide binding]; other site 446470014615 ABC-ATPase subunit interface; other site 446470014616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470014617 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446470014618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470014619 dimer interface [polypeptide binding]; other site 446470014620 conserved gate region; other site 446470014621 putative PBP binding loops; other site 446470014622 ABC-ATPase subunit interface; other site 446470014623 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446470014624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470014625 Walker A/P-loop; other site 446470014626 ATP binding site [chemical binding]; other site 446470014627 Q-loop/lid; other site 446470014628 ABC transporter signature motif; other site 446470014629 Walker B; other site 446470014630 D-loop; other site 446470014631 H-loop/switch region; other site 446470014632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470014633 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470014634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470014635 Walker A/P-loop; other site 446470014636 ATP binding site [chemical binding]; other site 446470014637 Q-loop/lid; other site 446470014638 ABC transporter signature motif; other site 446470014639 Walker B; other site 446470014640 D-loop; other site 446470014641 H-loop/switch region; other site 446470014642 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446470014643 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446470014644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470014645 dimer interface [polypeptide binding]; other site 446470014646 conserved gate region; other site 446470014647 putative PBP binding loops; other site 446470014648 ABC-ATPase subunit interface; other site 446470014649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470014650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470014651 dimer interface [polypeptide binding]; other site 446470014652 conserved gate region; other site 446470014653 putative PBP binding loops; other site 446470014654 ABC-ATPase subunit interface; other site 446470014655 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446470014656 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446470014657 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 446470014658 L-aspartate oxidase; Provisional; Region: PRK06175 446470014659 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446470014660 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 446470014661 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446470014662 catalytic loop [active] 446470014663 iron binding site [ion binding]; other site 446470014664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014665 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470014666 putative substrate translocation pore; other site 446470014667 GTP-binding protein YchF; Reviewed; Region: PRK09601 446470014668 YchF GTPase; Region: YchF; cd01900 446470014669 G1 box; other site 446470014670 GTP/Mg2+ binding site [chemical binding]; other site 446470014671 Switch I region; other site 446470014672 G2 box; other site 446470014673 Switch II region; other site 446470014674 G3 box; other site 446470014675 G4 box; other site 446470014676 G5 box; other site 446470014677 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446470014678 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 446470014679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470014680 dimerization interface [polypeptide binding]; other site 446470014681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470014682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470014683 dimer interface [polypeptide binding]; other site 446470014684 phosphorylation site [posttranslational modification] 446470014685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470014686 ATP binding site [chemical binding]; other site 446470014687 Mg2+ binding site [ion binding]; other site 446470014688 G-X-G motif; other site 446470014689 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 446470014690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470014691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470014692 active site 446470014693 phosphorylation site [posttranslational modification] 446470014694 intermolecular recognition site; other site 446470014695 dimerization interface [polypeptide binding]; other site 446470014696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470014697 DNA binding site [nucleotide binding] 446470014698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470014699 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470014700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470014701 Walker A/P-loop; other site 446470014702 ATP binding site [chemical binding]; other site 446470014703 Q-loop/lid; other site 446470014704 ABC transporter signature motif; other site 446470014705 Walker B; other site 446470014706 D-loop; other site 446470014707 H-loop/switch region; other site 446470014708 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470014709 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470014710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470014711 Walker A/P-loop; other site 446470014712 ATP binding site [chemical binding]; other site 446470014713 Q-loop/lid; other site 446470014714 ABC transporter signature motif; other site 446470014715 Walker B; other site 446470014716 D-loop; other site 446470014717 H-loop/switch region; other site 446470014718 Aerotolerance regulator N-terminal; Region: BatA; cl06567 446470014719 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446470014720 DNA binding site [nucleotide binding] 446470014721 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470014722 NB-ARC domain; Region: NB-ARC; pfam00931 446470014723 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 446470014724 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446470014725 RmuC family; Region: RmuC; pfam02646 446470014726 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446470014727 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446470014728 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446470014729 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 446470014730 generic binding surface II; other site 446470014731 generic binding surface I; other site 446470014732 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 446470014733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470014734 short chain dehydrogenase; Provisional; Region: PRK12747 446470014735 NAD(P) binding site [chemical binding]; other site 446470014736 active site 446470014737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014739 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 446470014740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470014741 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470014742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470014743 threonine synthase; Reviewed; Region: PRK06721 446470014744 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446470014745 homodimer interface [polypeptide binding]; other site 446470014746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470014747 catalytic residue [active] 446470014748 homoserine dehydrogenase; Provisional; Region: PRK06349 446470014749 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 446470014750 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446470014751 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446470014752 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446470014753 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446470014754 active site 446470014755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446470014756 substrate binding site [chemical binding]; other site 446470014757 catalytic residues [active] 446470014758 dimer interface [polypeptide binding]; other site 446470014759 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 446470014760 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 446470014761 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446470014762 active site 446470014763 HIGH motif; other site 446470014764 KMSK motif region; other site 446470014765 DALR anticodon binding domain; Region: DALR_1; smart00836 446470014766 anticodon binding site; other site 446470014767 tRNA binding surface [nucleotide binding]; other site 446470014768 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 446470014769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470014770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470014771 active site 446470014772 phosphorylation site [posttranslational modification] 446470014773 intermolecular recognition site; other site 446470014774 dimerization interface [polypeptide binding]; other site 446470014775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470014776 DNA binding residues [nucleotide binding] 446470014777 dimerization interface [polypeptide binding]; other site 446470014778 Histidine kinase; Region: HisKA_3; pfam07730 446470014779 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470014780 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470014781 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470014782 Walker A/P-loop; other site 446470014783 ATP binding site [chemical binding]; other site 446470014784 Q-loop/lid; other site 446470014785 ABC transporter signature motif; other site 446470014786 Walker B; other site 446470014787 D-loop; other site 446470014788 H-loop/switch region; other site 446470014789 short chain dehydrogenase; Provisional; Region: PRK06523 446470014790 classical (c) SDRs; Region: SDR_c; cd05233 446470014791 NAD(P) binding site [chemical binding]; other site 446470014792 active site 446470014793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470014794 DNA-binding site [nucleotide binding]; DNA binding site 446470014795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014797 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470014798 hypothetical protein; Validated; Region: PRK05868 446470014799 hypothetical protein; Provisional; Region: PRK07236 446470014800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470014801 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446470014802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470014803 NAD(P) binding site [chemical binding]; other site 446470014804 active site 446470014805 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446470014806 Peptidase family M28; Region: Peptidase_M28; pfam04389 446470014807 active site 446470014808 metal binding site [ion binding]; metal-binding site 446470014809 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 446470014810 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446470014811 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446470014812 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446470014813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014815 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446470014816 dimer interface [polypeptide binding]; other site 446470014817 putative radical transfer pathway; other site 446470014818 diiron center [ion binding]; other site 446470014819 tyrosyl radical; other site 446470014820 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 446470014821 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446470014822 active site 446470014823 dimer interface [polypeptide binding]; other site 446470014824 catalytic residues [active] 446470014825 effector binding site; other site 446470014826 R2 peptide binding site; other site 446470014827 CAAX protease self-immunity; Region: Abi; pfam02517 446470014828 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 446470014829 A new structural DNA glycosylase; Region: AlkD_like; cd06561 446470014830 active site 446470014831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014832 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 446470014833 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446470014834 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446470014835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470014836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470014838 putative substrate translocation pore; other site 446470014839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014840 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 446470014841 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 446470014842 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 446470014843 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470014844 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446470014845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470014846 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470014847 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 446470014848 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 446470014849 Multicopper oxidase; Region: Cu-oxidase; pfam00394 446470014850 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 446470014851 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470014852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014853 putative substrate translocation pore; other site 446470014854 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 446470014855 putative deacylase active site [active] 446470014856 Phosphotransferase enzyme family; Region: APH; pfam01636 446470014857 Fructosamine kinase; Region: Fructosamin_kin; cl17579 446470014858 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446470014859 MgtE intracellular N domain; Region: MgtE_N; smart00924 446470014860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446470014861 Divalent cation transporter; Region: MgtE; cl00786 446470014862 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470014863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470014864 putative DNA binding site [nucleotide binding]; other site 446470014865 putative Zn2+ binding site [ion binding]; other site 446470014866 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446470014867 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446470014868 AsnC family; Region: AsnC_trans_reg; pfam01037 446470014869 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446470014870 hypothetical protein; Provisional; Region: PRK07236 446470014871 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470014872 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446470014873 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446470014874 DinB superfamily; Region: DinB_2; pfam12867 446470014875 AAA ATPase domain; Region: AAA_16; pfam13191 446470014876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446470014877 binding surface 446470014878 TPR motif; other site 446470014879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470014880 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446470014881 active site 446470014882 metal binding site [ion binding]; metal-binding site 446470014883 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446470014884 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446470014885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470014886 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470014887 Walker A/P-loop; other site 446470014888 ATP binding site [chemical binding]; other site 446470014889 Q-loop/lid; other site 446470014890 ABC transporter signature motif; other site 446470014891 Walker B; other site 446470014892 D-loop; other site 446470014893 H-loop/switch region; other site 446470014894 EXLDI protein; Region: EXLDI; TIGR04342 446470014895 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470014896 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470014897 FAD binding domain; Region: FAD_binding_3; pfam01494 446470014898 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470014899 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470014900 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470014901 Histidine kinase; Region: HisKA_3; pfam07730 446470014902 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470014903 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470014904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470014905 active site 446470014906 phosphorylation site [posttranslational modification] 446470014907 intermolecular recognition site; other site 446470014908 dimerization interface [polypeptide binding]; other site 446470014909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470014910 DNA binding residues [nucleotide binding] 446470014911 dimerization interface [polypeptide binding]; other site 446470014912 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 446470014913 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470014914 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470014915 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446470014916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470014917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470014918 ATP binding site [chemical binding]; other site 446470014919 Mg2+ binding site [ion binding]; other site 446470014920 G-X-G motif; other site 446470014921 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446470014922 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446470014923 Walker A/P-loop; other site 446470014924 ATP binding site [chemical binding]; other site 446470014925 Q-loop/lid; other site 446470014926 ABC transporter signature motif; other site 446470014927 Walker B; other site 446470014928 D-loop; other site 446470014929 H-loop/switch region; other site 446470014930 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446470014931 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446470014932 TM-ABC transporter signature motif; other site 446470014933 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446470014934 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446470014935 Walker A/P-loop; other site 446470014936 ATP binding site [chemical binding]; other site 446470014937 Q-loop/lid; other site 446470014938 ABC transporter signature motif; other site 446470014939 Walker B; other site 446470014940 D-loop; other site 446470014941 H-loop/switch region; other site 446470014942 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446470014943 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446470014944 TM-ABC transporter signature motif; other site 446470014945 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446470014946 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446470014947 Amidohydrolase; Region: Amidohydro_2; pfam04909 446470014948 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446470014949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470014950 dimer interface [polypeptide binding]; other site 446470014951 conserved gate region; other site 446470014952 putative PBP binding loops; other site 446470014953 ABC-ATPase subunit interface; other site 446470014954 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446470014955 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446470014956 Walker A/P-loop; other site 446470014957 ATP binding site [chemical binding]; other site 446470014958 Q-loop/lid; other site 446470014959 ABC transporter signature motif; other site 446470014960 Walker B; other site 446470014961 D-loop; other site 446470014962 H-loop/switch region; other site 446470014963 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446470014964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470014965 dimer interface [polypeptide binding]; other site 446470014966 conserved gate region; other site 446470014967 putative PBP binding loops; other site 446470014968 ABC-ATPase subunit interface; other site 446470014969 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 446470014970 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470014971 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470014972 DNA binding site [nucleotide binding] 446470014973 domain linker motif; other site 446470014974 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470014975 ligand binding site [chemical binding]; other site 446470014976 dimerization interface [polypeptide binding]; other site 446470014977 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 446470014978 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470014979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470014980 NAD(P) binding site [chemical binding]; other site 446470014981 active site 446470014982 phosphoenolpyruvate synthase; Validated; Region: PRK06241 446470014983 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446470014984 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446470014985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470014986 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470014987 DNA binding site [nucleotide binding] 446470014988 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470014989 AAA ATPase domain; Region: AAA_16; pfam13191 446470014990 Predicted ATPase [General function prediction only]; Region: COG3903 446470014991 CAAX protease self-immunity; Region: Abi; pfam02517 446470014992 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470014993 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470014994 MarR family; Region: MarR_2; pfam12802 446470014995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470014997 putative substrate translocation pore; other site 446470014998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470014999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015001 Carboxylesterase family; Region: COesterase; pfam00135 446470015002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446470015003 substrate binding pocket [chemical binding]; other site 446470015004 catalytic triad [active] 446470015005 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446470015006 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446470015007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470015008 DNA-binding site [nucleotide binding]; DNA binding site 446470015009 FCD domain; Region: FCD; pfam07729 446470015010 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 446470015011 active site 446470015012 Mn binding site [ion binding]; other site 446470015013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470015014 NmrA-like family; Region: NmrA; pfam05368 446470015015 NAD(P) binding site [chemical binding]; other site 446470015016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470015017 TPR motif; other site 446470015018 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470015019 binding surface 446470015020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470015021 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446470015022 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446470015023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470015024 DNA-binding site [nucleotide binding]; DNA binding site 446470015025 UTRA domain; Region: UTRA; pfam07702 446470015026 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 446470015027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470015028 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446470015029 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470015030 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470015031 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 446470015032 FAD binding domain; Region: FAD_binding_4; pfam01565 446470015033 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446470015034 FtsX-like permease family; Region: FtsX; pfam02687 446470015035 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470015036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470015037 Walker A/P-loop; other site 446470015038 ATP binding site [chemical binding]; other site 446470015039 Q-loop/lid; other site 446470015040 ABC transporter signature motif; other site 446470015041 Walker B; other site 446470015042 D-loop; other site 446470015043 H-loop/switch region; other site 446470015044 Histidine kinase; Region: HisKA_3; pfam07730 446470015045 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446470015046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470015047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470015048 active site 446470015049 phosphorylation site [posttranslational modification] 446470015050 intermolecular recognition site; other site 446470015051 dimerization interface [polypeptide binding]; other site 446470015052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470015053 DNA binding residues [nucleotide binding] 446470015054 dimerization interface [polypeptide binding]; other site 446470015055 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470015056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470015057 active site 446470015058 phosphorylation site [posttranslational modification] 446470015059 intermolecular recognition site; other site 446470015060 dimerization interface [polypeptide binding]; other site 446470015061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470015062 DNA binding residues [nucleotide binding] 446470015063 dimerization interface [polypeptide binding]; other site 446470015064 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 446470015065 Putative sensor; Region: Sensor; pfam13796 446470015066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470015067 Histidine kinase; Region: HisKA_3; pfam07730 446470015068 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 446470015069 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446470015070 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446470015071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470015072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470015073 active site 446470015074 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 446470015075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470015076 DNA-binding site [nucleotide binding]; DNA binding site 446470015077 FCD domain; Region: FCD; pfam07729 446470015078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 446470015079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470015080 putative metal binding site [ion binding]; other site 446470015081 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 446470015082 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470015083 NAD(P) binding site [chemical binding]; other site 446470015084 putative active site [active] 446470015085 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 446470015086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470015087 FeS/SAM binding site; other site 446470015088 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 446470015089 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 446470015090 Flavoprotein; Region: Flavoprotein; pfam02441 446470015091 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470015092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470015093 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 446470015094 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 446470015095 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 446470015096 putative active site [active] 446470015097 metal binding site [ion binding]; metal-binding site 446470015098 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446470015099 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 446470015100 PYR/PP interface [polypeptide binding]; other site 446470015101 dimer interface [polypeptide binding]; other site 446470015102 TPP binding site [chemical binding]; other site 446470015103 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 446470015104 TPP-binding site; other site 446470015105 cytidylyltransferase; Region: cytidylyltransferase; cd02170 446470015106 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 446470015107 active site 446470015108 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446470015109 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446470015110 tetramer interface [polypeptide binding]; other site 446470015111 active site 446470015112 Mg2+/Mn2+ binding site [ion binding]; other site 446470015113 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446470015114 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446470015115 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446470015116 substrate binding site; other site 446470015117 dimer interface; other site 446470015118 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446470015119 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446470015120 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446470015121 Walker A/P-loop; other site 446470015122 ATP binding site [chemical binding]; other site 446470015123 Q-loop/lid; other site 446470015124 ABC transporter signature motif; other site 446470015125 Walker B; other site 446470015126 D-loop; other site 446470015127 H-loop/switch region; other site 446470015128 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446470015129 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 446470015130 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 446470015131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470015132 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446470015133 putative ADP-binding pocket [chemical binding]; other site 446470015134 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446470015135 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446470015136 putative catalytic site [active] 446470015137 putative metal binding site [ion binding]; other site 446470015138 putative phosphate binding site [ion binding]; other site 446470015139 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 446470015140 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446470015141 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446470015142 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446470015143 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446470015144 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 446470015145 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 446470015146 active site 446470015147 metal binding site [ion binding]; metal-binding site 446470015148 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 446470015149 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 446470015150 active site 446470015151 metal-binding site 446470015152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470015153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470015154 DNA binding residues [nucleotide binding] 446470015155 dimerization interface [polypeptide binding]; other site 446470015156 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446470015157 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 446470015158 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 446470015159 Imelysin; Region: Peptidase_M75; pfam09375 446470015160 Iron permease FTR1 family; Region: FTR1; cl00475 446470015161 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 446470015162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470015163 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 446470015164 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446470015165 putative dimerization interface [polypeptide binding]; other site 446470015166 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446470015167 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 446470015168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470015169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470015170 DNA binding residues [nucleotide binding] 446470015171 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 446470015172 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446470015173 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446470015174 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 446470015175 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 446470015176 CoA binding domain; Region: CoA_binding; pfam02629 446470015177 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 446470015178 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 446470015179 tRNA; other site 446470015180 putative tRNA binding site [nucleotide binding]; other site 446470015181 putative NADP binding site [chemical binding]; other site 446470015182 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 446470015183 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 446470015184 active site 446470015185 homodimer interface [polypeptide binding]; other site 446470015186 SAM binding site [chemical binding]; other site 446470015187 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 446470015188 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446470015189 active site 446470015190 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446470015191 dimer interface [polypeptide binding]; other site 446470015192 active site 446470015193 Schiff base residues; other site 446470015194 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470015195 DinB superfamily; Region: DinB_2; pfam12867 446470015196 bile acid transporter; Region: bass; TIGR00841 446470015197 Sodium Bile acid symporter family; Region: SBF; cl17470 446470015198 FAD binding domain; Region: FAD_binding_4; pfam01565 446470015199 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 446470015200 AAA domain; Region: AAA_18; pfam13238 446470015201 AAA domain; Region: AAA_17; pfam13207 446470015202 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446470015203 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 446470015204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470015205 catalytic residue [active] 446470015206 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446470015207 metal binding site 2 [ion binding]; metal-binding site 446470015208 putative DNA binding helix; other site 446470015209 metal binding site 1 [ion binding]; metal-binding site 446470015210 dimer interface [polypeptide binding]; other site 446470015211 structural Zn2+ binding site [ion binding]; other site 446470015212 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 446470015213 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446470015214 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446470015215 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470015216 PLD-like domain; Region: PLDc_2; pfam13091 446470015217 putative active site [active] 446470015218 catalytic site [active] 446470015219 PLD-like domain; Region: PLDc_2; pfam13091 446470015220 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446470015221 putative active site [active] 446470015222 catalytic site [active] 446470015223 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 446470015224 Transglycosylase; Region: Transgly; pfam00912 446470015225 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446470015226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446470015227 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 446470015228 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446470015229 putative active site [active] 446470015230 putative metal binding site [ion binding]; other site 446470015231 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446470015232 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 446470015233 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446470015234 active site 446470015235 HIGH motif; other site 446470015236 KMSKS motif; other site 446470015237 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446470015238 tRNA binding surface [nucleotide binding]; other site 446470015239 anticodon binding site; other site 446470015240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015242 WHG domain; Region: WHG; pfam13305 446470015243 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 446470015244 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 446470015245 NADP binding site [chemical binding]; other site 446470015246 putative substrate binding site [chemical binding]; other site 446470015247 active site 446470015248 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446470015249 Peptidase family M28; Region: Peptidase_M28; pfam04389 446470015250 active site 446470015251 metal binding site [ion binding]; metal-binding site 446470015252 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 446470015253 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446470015254 MarR family; Region: MarR; pfam01047 446470015255 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 446470015256 agmatinase; Region: agmatinase; TIGR01230 446470015257 Agmatinase-like family; Region: Agmatinase-like; cd09990 446470015258 active site 446470015259 oligomer interface [polypeptide binding]; other site 446470015260 Mn binding site [ion binding]; other site 446470015261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470015262 putative DNA binding site [nucleotide binding]; other site 446470015263 putative Zn2+ binding site [ion binding]; other site 446470015264 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470015265 putative DNA binding site [nucleotide binding]; other site 446470015266 putative Zn2+ binding site [ion binding]; other site 446470015267 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 446470015268 putative hydrophobic ligand binding site [chemical binding]; other site 446470015269 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470015270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470015271 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446470015272 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470015273 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470015274 DNA binding residues [nucleotide binding] 446470015275 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470015276 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470015277 RibD C-terminal domain; Region: RibD_C; cl17279 446470015278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470015279 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470015280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015282 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446470015283 RibD C-terminal domain; Region: RibD_C; cl17279 446470015284 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470015285 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470015286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470015287 non-specific DNA binding site [nucleotide binding]; other site 446470015288 salt bridge; other site 446470015289 sequence-specific DNA binding site [nucleotide binding]; other site 446470015290 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446470015291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470015292 S-adenosylmethionine binding site [chemical binding]; other site 446470015293 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446470015294 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 446470015295 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446470015296 MMPL family; Region: MMPL; pfam03176 446470015297 MMPL family; Region: MMPL; pfam03176 446470015298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470015299 Walker A/P-loop; other site 446470015300 ATP binding site [chemical binding]; other site 446470015301 Q-loop/lid; other site 446470015302 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470015303 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446470015304 YCII-related domain; Region: YCII; cl00999 446470015305 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446470015306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470015307 Predicted transcriptional regulator [Transcription]; Region: COG1959 446470015308 Transcriptional regulator; Region: Rrf2; pfam02082 446470015309 Transcriptional regulator; Region: Rrf2; cl17282 446470015310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470015311 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446470015312 NAD(P) binding site [chemical binding]; other site 446470015313 active site 446470015314 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446470015315 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446470015316 structural tetrad; other site 446470015317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015319 RibD C-terminal domain; Region: RibD_C; cl17279 446470015320 MFS transport protein AraJ; Provisional; Region: PRK10091 446470015321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470015322 putative substrate translocation pore; other site 446470015323 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 446470015324 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446470015325 putative ligand binding site [chemical binding]; other site 446470015326 putative NAD binding site [chemical binding]; other site 446470015327 catalytic site [active] 446470015328 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446470015329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470015330 dimer interface [polypeptide binding]; other site 446470015331 conserved gate region; other site 446470015332 ABC-ATPase subunit interface; other site 446470015333 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470015334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470015335 dimer interface [polypeptide binding]; other site 446470015336 conserved gate region; other site 446470015337 putative PBP binding loops; other site 446470015338 ABC-ATPase subunit interface; other site 446470015339 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446470015340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470015341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470015342 DNA binding site [nucleotide binding] 446470015343 domain linker motif; other site 446470015344 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446470015345 dimerization interface [polypeptide binding]; other site 446470015346 ligand binding site [chemical binding]; other site 446470015347 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446470015348 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446470015349 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 446470015350 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470015351 Proline dehydrogenase; Region: Pro_dh; cl03282 446470015352 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446470015353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470015354 non-specific DNA binding site [nucleotide binding]; other site 446470015355 salt bridge; other site 446470015356 sequence-specific DNA binding site [nucleotide binding]; other site 446470015357 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 446470015358 DNA binding domain, excisionase family; Region: excise; TIGR01764 446470015359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470015360 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446470015361 NAD(P) binding site [chemical binding]; other site 446470015362 active site 446470015363 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470015364 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 446470015365 putative acyl-acceptor binding pocket; other site 446470015366 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 446470015367 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 446470015368 allantoate amidohydrolase; Reviewed; Region: PRK09290 446470015369 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 446470015370 active site 446470015371 metal binding site [ion binding]; metal-binding site 446470015372 dimer interface [polypeptide binding]; other site 446470015373 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 446470015374 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446470015375 active site 446470015376 Cytochrome C biogenesis protein; Region: CcmH; cl01179 446470015377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470015378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470015379 putative substrate translocation pore; other site 446470015380 Phosphotransferase enzyme family; Region: APH; pfam01636 446470015381 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 446470015382 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446470015383 catalytic residues [active] 446470015384 Predicted integral membrane protein [Function unknown]; Region: COG5660 446470015385 Putative zinc-finger; Region: zf-HC2; pfam13490 446470015386 CopC domain; Region: CopC; pfam04234 446470015387 Copper resistance protein D; Region: CopD; cl00563 446470015388 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 446470015389 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 446470015390 Part of AAA domain; Region: AAA_19; pfam13245 446470015391 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446470015392 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446470015393 calcium binding site 2 [ion binding]; other site 446470015394 active site 446470015395 catalytic triad [active] 446470015396 calcium binding site 1 [ion binding]; other site 446470015397 CAAX protease self-immunity; Region: Abi; pfam02517 446470015398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470015399 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 446470015400 Histidine kinase; Region: HisKA_3; pfam07730 446470015401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470015402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470015403 active site 446470015404 phosphorylation site [posttranslational modification] 446470015405 intermolecular recognition site; other site 446470015406 dimerization interface [polypeptide binding]; other site 446470015407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470015408 DNA binding residues [nucleotide binding] 446470015409 dimerization interface [polypeptide binding]; other site 446470015410 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446470015411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470015412 motif II; other site 446470015413 Predicted transcriptional regulator [Transcription]; Region: COG2378 446470015414 HTH domain; Region: HTH_11; pfam08279 446470015415 WYL domain; Region: WYL; pfam13280 446470015416 hypothetical protein; Provisional; Region: PRK08317 446470015417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470015418 S-adenosylmethionine binding site [chemical binding]; other site 446470015419 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470015420 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470015421 DNA binding residues [nucleotide binding] 446470015422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470015423 Coenzyme A binding pocket [chemical binding]; other site 446470015424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470015425 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470015426 active site 446470015427 catalytic tetrad [active] 446470015428 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446470015429 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 446470015430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470015431 ABC transporter signature motif; other site 446470015432 Walker B; other site 446470015433 D-loop; other site 446470015434 H-loop/switch region; other site 446470015435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470015436 Walker A/P-loop; other site 446470015437 ATP binding site [chemical binding]; other site 446470015438 Q-loop/lid; other site 446470015439 ABC transporter signature motif; other site 446470015440 Walker B; other site 446470015441 D-loop; other site 446470015442 H-loop/switch region; other site 446470015443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015444 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470015445 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 446470015446 NADP+ binding site [chemical binding]; other site 446470015447 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470015448 Cytochrome P450; Region: p450; cl12078 446470015449 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 446470015450 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 446470015451 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 446470015452 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 446470015453 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446470015454 active site 446470015455 nucleotide binding site [chemical binding]; other site 446470015456 HIGH motif; other site 446470015457 KMSKS motif; other site 446470015458 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 446470015459 ligand-binding site [chemical binding]; other site 446470015460 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 446470015461 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 446470015462 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 446470015463 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 446470015464 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446470015465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470015466 ATP binding site [chemical binding]; other site 446470015467 putative Mg++ binding site [ion binding]; other site 446470015468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470015469 nucleotide binding region [chemical binding]; other site 446470015470 ATP-binding site [chemical binding]; other site 446470015471 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 446470015472 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 446470015473 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 446470015474 homodimer interface [polypeptide binding]; other site 446470015475 metal binding site [ion binding]; metal-binding site 446470015476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470015477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470015478 Coenzyme A binding pocket [chemical binding]; other site 446470015479 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446470015480 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446470015481 inhibitor-cofactor binding pocket; inhibition site 446470015482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470015483 catalytic residue [active] 446470015484 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 446470015485 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446470015486 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 446470015487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446470015488 binding surface 446470015489 TPR motif; other site 446470015490 enolase; Provisional; Region: eno; PRK00077 446470015491 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446470015492 dimer interface [polypeptide binding]; other site 446470015493 metal binding site [ion binding]; metal-binding site 446470015494 substrate binding pocket [chemical binding]; other site 446470015495 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446470015496 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470015497 active site 446470015498 substrate binding sites [chemical binding]; other site 446470015499 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446470015500 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446470015501 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446470015502 Septum formation initiator; Region: DivIC; pfam04977 446470015503 Protein of unknown function (DUF501); Region: DUF501; pfam04417 446470015504 exopolyphosphatase; Region: exo_poly_only; TIGR03706 446470015505 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446470015506 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 446470015507 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446470015508 active site 446470015509 catalytic triad [active] 446470015510 oxyanion hole [active] 446470015511 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 446470015512 CGNR zinc finger; Region: zf-CGNR; pfam11706 446470015513 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470015514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470015515 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446470015516 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446470015517 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446470015518 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 446470015519 catalytic site [active] 446470015520 BNR repeat-like domain; Region: BNR_2; pfam13088 446470015521 Asp-box motif; other site 446470015522 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 446470015523 generic binding surface I; other site 446470015524 generic binding surface II; other site 446470015525 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 446470015526 putative active site [active] 446470015527 putative catalytic site [active] 446470015528 putative Mg binding site IVb [ion binding]; other site 446470015529 putative phosphate binding site [ion binding]; other site 446470015530 putative DNA binding site [nucleotide binding]; other site 446470015531 putative Mg binding site IVa [ion binding]; other site 446470015532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446470015533 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446470015534 metal-binding site [ion binding] 446470015535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446470015536 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 446470015537 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446470015538 metal-binding site [ion binding] 446470015539 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470015540 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 446470015541 active site 446470015542 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446470015543 active site 446470015544 catalytic triad [active] 446470015545 oxyanion hole [active] 446470015546 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446470015547 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446470015548 active site 446470015549 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 446470015550 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446470015551 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 446470015552 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446470015553 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470015554 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470015555 H+ Antiporter protein; Region: 2A0121; TIGR00900 446470015556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470015557 putative substrate translocation pore; other site 446470015558 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470015559 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446470015560 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446470015561 hypothetical protein; Provisional; Region: PRK08236 446470015562 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 446470015563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470015564 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470015565 active site 446470015566 ATP binding site [chemical binding]; other site 446470015567 substrate binding site [chemical binding]; other site 446470015568 activation loop (A-loop); other site 446470015569 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446470015570 DNA-binding site [nucleotide binding]; DNA binding site 446470015571 RNA-binding motif; other site 446470015572 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446470015573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015574 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446470015575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470015576 NAD(P) binding site [chemical binding]; other site 446470015577 active site 446470015578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015580 SnoaL-like domain; Region: SnoaL_4; pfam13577 446470015581 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 446470015582 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 446470015583 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 446470015584 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446470015585 Type II/IV secretion system protein; Region: T2SE; pfam00437 446470015586 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446470015587 hexamer interface [polypeptide binding]; other site 446470015588 Walker B motif; other site 446470015589 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446470015590 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 446470015591 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 446470015592 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446470015593 active site 446470015594 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446470015595 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 446470015596 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446470015597 active site 446470015598 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470015599 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470015600 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446470015601 NlpC/P60 family; Region: NLPC_P60; pfam00877 446470015602 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446470015603 putative homotetramer interface [polypeptide binding]; other site 446470015604 putative homodimer interface [polypeptide binding]; other site 446470015605 putative allosteric switch controlling residues; other site 446470015606 putative metal binding site [ion binding]; other site 446470015607 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446470015608 metal-binding site [ion binding] 446470015609 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446470015610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470015611 S-adenosylmethionine binding site [chemical binding]; other site 446470015612 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470015613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470015614 dimer interface [polypeptide binding]; other site 446470015615 conserved gate region; other site 446470015616 putative PBP binding loops; other site 446470015617 ABC-ATPase subunit interface; other site 446470015618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470015619 dimer interface [polypeptide binding]; other site 446470015620 conserved gate region; other site 446470015621 ABC-ATPase subunit interface; other site 446470015622 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 446470015623 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470015624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470015625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470015626 DNA binding site [nucleotide binding] 446470015627 domain linker motif; other site 446470015628 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 446470015629 putative dimerization interface [polypeptide binding]; other site 446470015630 putative ligand binding site [chemical binding]; other site 446470015631 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446470015632 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446470015633 active site 446470015634 catalytic site [active] 446470015635 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446470015636 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446470015637 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 446470015638 hypothetical protein; Provisional; Region: PRK06185 446470015639 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470015640 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446470015641 Domain of unknown function DUF21; Region: DUF21; pfam01595 446470015642 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446470015643 Transporter associated domain; Region: CorC_HlyC; smart01091 446470015644 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446470015645 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 446470015646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470015647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470015648 DNA binding residues [nucleotide binding] 446470015649 Anti-sigma-K factor rskA; Region: RskA; pfam10099 446470015650 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 446470015651 DNA photolyase; Region: DNA_photolyase; pfam00875 446470015652 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 446470015653 Fasciclin domain; Region: Fasciclin; pfam02469 446470015654 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 446470015655 Moco binding site; other site 446470015656 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446470015657 metal coordination site [ion binding]; other site 446470015658 dimerization interface [polypeptide binding]; other site 446470015659 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 446470015660 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446470015661 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446470015662 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446470015663 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446470015664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446470015665 substrate binding site [chemical binding]; other site 446470015666 oxyanion hole (OAH) forming residues; other site 446470015667 trimer interface [polypeptide binding]; other site 446470015668 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 446470015669 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 446470015670 putative molybdopterin cofactor binding site [chemical binding]; other site 446470015671 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 446470015672 putative molybdopterin cofactor binding site; other site 446470015673 Conserved TM helix; Region: TM_helix; pfam05552 446470015674 Conserved TM helix; Region: TM_helix; pfam05552 446470015675 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446470015676 trimer interface [polypeptide binding]; other site 446470015677 active site 446470015678 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 446470015679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470015680 Coenzyme A binding pocket [chemical binding]; other site 446470015681 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446470015682 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 446470015683 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 446470015684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470015685 active site 446470015686 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 446470015687 Transglycosylase; Region: Transgly; pfam00912 446470015688 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446470015689 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446470015690 Predicted transcriptional regulators [Transcription]; Region: COG1695 446470015691 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446470015692 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 446470015693 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 446470015694 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470015695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470015696 active site 446470015697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015699 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 446470015700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470015701 putative substrate translocation pore; other site 446470015702 hypothetical protein; Provisional; Region: PRK07236 446470015703 hypothetical protein; Provisional; Region: PRK07588 446470015704 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446470015705 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446470015706 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470015707 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446470015708 catalytic site [active] 446470015709 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 446470015710 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 446470015711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470015712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446470015713 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470015714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470015715 active site 446470015716 ATP binding site [chemical binding]; other site 446470015717 substrate binding site [chemical binding]; other site 446470015718 activation loop (A-loop); other site 446470015719 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 446470015720 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470015721 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470015722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470015723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470015724 dimerization interface [polypeptide binding]; other site 446470015725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470015726 dimer interface [polypeptide binding]; other site 446470015727 phosphorylation site [posttranslational modification] 446470015728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470015729 ATP binding site [chemical binding]; other site 446470015730 Mg2+ binding site [ion binding]; other site 446470015731 G-X-G motif; other site 446470015732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470015733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470015734 active site 446470015735 phosphorylation site [posttranslational modification] 446470015736 intermolecular recognition site; other site 446470015737 dimerization interface [polypeptide binding]; other site 446470015738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470015739 DNA binding site [nucleotide binding] 446470015740 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470015741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446470015742 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446470015743 Walker A/P-loop; other site 446470015744 ATP binding site [chemical binding]; other site 446470015745 Q-loop/lid; other site 446470015746 ABC transporter signature motif; other site 446470015747 Walker B; other site 446470015748 D-loop; other site 446470015749 H-loop/switch region; other site 446470015750 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446470015751 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446470015752 FtsX-like permease family; Region: FtsX; pfam02687 446470015753 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446470015754 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 446470015755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470015756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470015757 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446470015758 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446470015759 substrate binding pocket [chemical binding]; other site 446470015760 chain length determination region; other site 446470015761 substrate-Mg2+ binding site; other site 446470015762 catalytic residues [active] 446470015763 aspartate-rich region 1; other site 446470015764 active site lid residues [active] 446470015765 aspartate-rich region 2; other site 446470015766 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446470015767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470015768 Coenzyme A binding pocket [chemical binding]; other site 446470015769 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 446470015770 4Fe-4S binding domain; Region: Fer4; pfam00037 446470015771 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446470015772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470015773 Walker A/P-loop; other site 446470015774 ATP binding site [chemical binding]; other site 446470015775 ABC transporter signature motif; other site 446470015776 Walker B; other site 446470015777 D-loop; other site 446470015778 H-loop/switch region; other site 446470015779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470015780 Walker A/P-loop; other site 446470015781 ATP binding site [chemical binding]; other site 446470015782 Q-loop/lid; other site 446470015783 ABC transporter signature motif; other site 446470015784 Walker B; other site 446470015785 D-loop; other site 446470015786 H-loop/switch region; other site 446470015787 malonic semialdehyde reductase; Provisional; Region: PRK10538 446470015788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470015789 NAD(P) binding site [chemical binding]; other site 446470015790 active site 446470015791 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446470015792 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446470015793 putative ADP-binding pocket [chemical binding]; other site 446470015794 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446470015795 Phytase; Region: Phytase; cl17685 446470015796 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446470015797 RibD C-terminal domain; Region: RibD_C; cl17279 446470015798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015800 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470015801 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 446470015802 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446470015803 cleavage site 446470015804 active site 446470015805 substrate binding sites [chemical binding]; other site 446470015806 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446470015807 core dimer interface [polypeptide binding]; other site 446470015808 peripheral dimer interface [polypeptide binding]; other site 446470015809 L10 interface [polypeptide binding]; other site 446470015810 L11 interface [polypeptide binding]; other site 446470015811 putative EF-Tu interaction site [polypeptide binding]; other site 446470015812 putative EF-G interaction site [polypeptide binding]; other site 446470015813 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 446470015814 23S rRNA interface [nucleotide binding]; other site 446470015815 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 446470015816 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 446470015817 mRNA/rRNA interface [nucleotide binding]; other site 446470015818 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446470015819 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446470015820 23S rRNA interface [nucleotide binding]; other site 446470015821 L7/L12 interface [polypeptide binding]; other site 446470015822 putative thiostrepton binding site; other site 446470015823 L25 interface [polypeptide binding]; other site 446470015824 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446470015825 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446470015826 putative homodimer interface [polypeptide binding]; other site 446470015827 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 446470015828 heterodimer interface [polypeptide binding]; other site 446470015829 homodimer interface [polypeptide binding]; other site 446470015830 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 446470015831 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446470015832 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 446470015833 NADH dehydrogenase subunit B; Validated; Region: PRK06411 446470015834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 446470015835 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 446470015836 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 446470015837 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 446470015838 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 446470015839 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 446470015840 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446470015841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470015842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470015843 DNA binding residues [nucleotide binding] 446470015844 AAA domain; Region: AAA_31; pfam13614 446470015845 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446470015846 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446470015847 DNA binding residues [nucleotide binding] 446470015848 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 446470015849 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446470015850 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 446470015851 NAD binding site [chemical binding]; other site 446470015852 Phe binding site; other site 446470015853 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 446470015854 Subtilisin inhibitor-like; Region: SSI; cl11594 446470015855 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446470015856 nucleoside/Zn binding site; other site 446470015857 dimer interface [polypeptide binding]; other site 446470015858 catalytic motif [active] 446470015859 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 446470015860 PQQ-like domain; Region: PQQ_2; pfam13360 446470015861 Protease prsW family; Region: PrsW-protease; pfam13367 446470015862 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446470015863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446470015864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446470015865 catalytic residue [active] 446470015866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015868 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446470015869 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 446470015870 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 446470015871 HIGH motif; other site 446470015872 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446470015873 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 446470015874 active site 446470015875 KMSKS motif; other site 446470015876 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446470015877 tRNA binding surface [nucleotide binding]; other site 446470015878 anticodon binding site; other site 446470015879 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 446470015880 DoxX-like family; Region: DoxX_2; pfam13564 446470015881 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 446470015882 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 446470015883 Walker A; other site 446470015884 putative acyltransferase; Provisional; Region: PRK05790 446470015885 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446470015886 dimer interface [polypeptide binding]; other site 446470015887 active site 446470015888 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470015889 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 446470015890 dimer interface [polypeptide binding]; other site 446470015891 substrate binding site [chemical binding]; other site 446470015892 metal binding site [ion binding]; metal-binding site 446470015893 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470015894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470015895 NAD(P) binding site [chemical binding]; other site 446470015896 active site 446470015897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470015898 MarR family; Region: MarR_2; pfam12802 446470015899 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 446470015900 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446470015901 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446470015902 Cation efflux family; Region: Cation_efflux; pfam01545 446470015903 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446470015904 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 446470015905 dimer interface [polypeptide binding]; other site 446470015906 active site 446470015907 Uncharacterized conserved protein [Function unknown]; Region: COG2835 446470015908 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446470015909 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446470015910 active site 446470015911 substrate binding site [chemical binding]; other site 446470015912 metal binding site [ion binding]; metal-binding site 446470015913 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446470015914 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 446470015915 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 446470015916 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 446470015917 Substrate binding site; other site 446470015918 Cupin domain; Region: Cupin_2; cl17218 446470015919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470015920 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 446470015921 Ribosomal L18 C-terminal region; Region: Ribosomal_L18_c; pfam14204 446470015922 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 446470015923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470015924 acyl-activating enzyme (AAE) consensus motif; other site 446470015925 AMP binding site [chemical binding]; other site 446470015926 active site 446470015927 CoA binding site [chemical binding]; other site 446470015928 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446470015929 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446470015930 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470015931 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470015932 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470015933 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470015934 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446470015935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446470015936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470015937 active site 446470015938 phosphorylation site [posttranslational modification] 446470015939 intermolecular recognition site; other site 446470015940 dimerization interface [polypeptide binding]; other site 446470015941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470015942 DNA binding site [nucleotide binding] 446470015943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446470015944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446470015945 dimerization interface [polypeptide binding]; other site 446470015946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446470015947 dimer interface [polypeptide binding]; other site 446470015948 phosphorylation site [posttranslational modification] 446470015949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470015950 ATP binding site [chemical binding]; other site 446470015951 Mg2+ binding site [ion binding]; other site 446470015952 G-X-G motif; other site 446470015953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470015954 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470015955 active site 446470015956 FAD binding domain; Region: FAD_binding_3; pfam01494 446470015957 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470015958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470015959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470015960 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 446470015961 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 446470015962 catalytic residues [active] 446470015963 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470015964 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 446470015965 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 446470015966 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470015967 active site 446470015968 metal binding site [ion binding]; metal-binding site 446470015969 hexamer interface [polypeptide binding]; other site 446470015970 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470015971 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446470015972 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446470015973 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446470015974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470015975 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446470015976 Beta propeller domain; Region: Beta_propel; pfam09826 446470015977 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446470015978 Amidinotransferase; Region: Amidinotransf; cl12043 446470015979 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 446470015980 ATP binding site [chemical binding]; other site 446470015981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446470015982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446470015983 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446470015984 dimerization interface [polypeptide binding]; other site 446470015985 substrate binding pocket [chemical binding]; other site 446470015986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470015987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470015988 Coenzyme A binding pocket [chemical binding]; other site 446470015989 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446470015990 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446470015991 active site 446470015992 catalytic site [active] 446470015993 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 446470015994 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446470015995 active site 446470015996 YopR Core; Region: YopR_core; cl07585 446470015997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470015998 S-adenosylmethionine binding site [chemical binding]; other site 446470015999 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446470016000 dimer interface [polypeptide binding]; other site 446470016001 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446470016002 FAD binding domain; Region: FAD_binding_4; pfam01565 446470016003 Berberine and berberine like; Region: BBE; pfam08031 446470016004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470016005 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470016006 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470016007 DNA binding residues [nucleotide binding] 446470016008 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470016009 Serine hydrolase; Region: Ser_hydrolase; cl17834 446470016010 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 446470016011 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 446470016012 putative active site [active] 446470016013 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446470016014 active site 446470016015 catalytic triad [active] 446470016016 oxyanion hole [active] 446470016017 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446470016018 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446470016019 putative sugar binding sites [chemical binding]; other site 446470016020 Q-X-W motif; other site 446470016021 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470016022 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 446470016023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470016024 Walker A/P-loop; other site 446470016025 ATP binding site [chemical binding]; other site 446470016026 Q-loop/lid; other site 446470016027 ABC transporter signature motif; other site 446470016028 Walker B; other site 446470016029 D-loop; other site 446470016030 H-loop/switch region; other site 446470016031 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470016032 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446470016033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470016034 Walker A/P-loop; other site 446470016035 ATP binding site [chemical binding]; other site 446470016036 Q-loop/lid; other site 446470016037 ABC transporter signature motif; other site 446470016038 Walker B; other site 446470016039 D-loop; other site 446470016040 H-loop/switch region; other site 446470016041 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446470016042 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446470016043 TPP-binding site [chemical binding]; other site 446470016044 tetramer interface [polypeptide binding]; other site 446470016045 heterodimer interface [polypeptide binding]; other site 446470016046 phosphorylation loop region [posttranslational modification] 446470016047 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446470016048 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446470016049 alpha subunit interface [polypeptide binding]; other site 446470016050 TPP binding site [chemical binding]; other site 446470016051 heterodimer interface [polypeptide binding]; other site 446470016052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446470016053 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446470016054 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446470016055 E3 interaction surface; other site 446470016056 lipoyl attachment site [posttranslational modification]; other site 446470016057 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446470016058 putative acetyltransferase; Provisional; Region: PRK03624 446470016059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016060 Coenzyme A binding pocket [chemical binding]; other site 446470016061 Peptidase family M48; Region: Peptidase_M48; cl12018 446470016062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470016063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470016064 putative substrate translocation pore; other site 446470016065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446470016066 MarR family; Region: MarR; pfam01047 446470016067 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 446470016068 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 446470016069 Ligand Binding Site [chemical binding]; other site 446470016070 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446470016071 PspC domain; Region: PspC; pfam04024 446470016072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446470016073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470016074 ATP binding site [chemical binding]; other site 446470016075 G-X-G motif; other site 446470016076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446470016077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446470016078 active site 446470016079 phosphorylation site [posttranslational modification] 446470016080 intermolecular recognition site; other site 446470016081 dimerization interface [polypeptide binding]; other site 446470016082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446470016083 DNA binding residues [nucleotide binding] 446470016084 dimerization interface [polypeptide binding]; other site 446470016085 Chorismate mutase type II; Region: CM_2; cl00693 446470016086 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 446470016087 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446470016088 Part of AAA domain; Region: AAA_19; pfam13245 446470016089 Family description; Region: UvrD_C_2; pfam13538 446470016090 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470016091 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470016092 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470016093 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470016094 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446470016095 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446470016096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446470016097 ATP binding site [chemical binding]; other site 446470016098 putative Mg++ binding site [ion binding]; other site 446470016099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446470016100 nucleotide binding region [chemical binding]; other site 446470016101 ATP-binding site [chemical binding]; other site 446470016102 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446470016103 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446470016104 Radical SAM superfamily; Region: Radical_SAM; pfam04055 446470016105 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446470016106 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446470016107 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446470016108 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446470016109 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446470016110 inhibitor site; inhibition site 446470016111 active site 446470016112 dimer interface [polypeptide binding]; other site 446470016113 catalytic residue [active] 446470016114 putative sialic acid transporter; Provisional; Region: PRK03893 446470016115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470016116 putative substrate translocation pore; other site 446470016117 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446470016118 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446470016119 inhibitor site; inhibition site 446470016120 active site 446470016121 dimer interface [polypeptide binding]; other site 446470016122 catalytic residue [active] 446470016123 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470016124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470016125 DNA-binding site [nucleotide binding]; DNA binding site 446470016126 FCD domain; Region: FCD; pfam07729 446470016127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470016128 Walker A/P-loop; other site 446470016129 ATP binding site [chemical binding]; other site 446470016130 Q-loop/lid; other site 446470016131 ABC transporter signature motif; other site 446470016132 Walker B; other site 446470016133 D-loop; other site 446470016134 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446470016135 Predicted membrane protein [Function unknown]; Region: COG1511 446470016136 Predicted membrane protein [Function unknown]; Region: COG1511 446470016137 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446470016138 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 446470016139 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446470016140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016141 Coenzyme A binding pocket [chemical binding]; other site 446470016142 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 446470016143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016144 Coenzyme A binding pocket [chemical binding]; other site 446470016145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470016146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016147 Coenzyme A binding pocket [chemical binding]; other site 446470016148 putative acetyltransferase; Provisional; Region: PRK03624 446470016149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016150 Coenzyme A binding pocket [chemical binding]; other site 446470016151 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470016152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016153 Coenzyme A binding pocket [chemical binding]; other site 446470016154 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470016155 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 446470016156 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446470016157 NAD(P) binding site [chemical binding]; other site 446470016158 catalytic residues [active] 446470016159 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446470016160 DNA-binding site [nucleotide binding]; DNA binding site 446470016161 RNA-binding motif; other site 446470016162 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446470016163 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446470016164 ring oligomerisation interface [polypeptide binding]; other site 446470016165 ATP/Mg binding site [chemical binding]; other site 446470016166 stacking interactions; other site 446470016167 hinge regions; other site 446470016168 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470016169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470016170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470016171 DNA binding residues [nucleotide binding] 446470016172 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446470016173 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470016174 DNA binding residues [nucleotide binding] 446470016175 CutC family; Region: CutC; cl01218 446470016176 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 446470016177 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 446470016178 active site 446470016179 dimer interface [polypeptide binding]; other site 446470016180 SnoaL-like domain; Region: SnoaL_2; pfam12680 446470016181 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470016182 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470016183 active site 446470016184 catalytic tetrad [active] 446470016185 L-asparaginase II; Region: Asparaginase_II; pfam06089 446470016186 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 446470016187 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 446470016188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470016189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470016190 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 446470016191 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 446470016192 active site 446470016193 catalytic site [active] 446470016194 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446470016195 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446470016196 glutamine binding [chemical binding]; other site 446470016197 catalytic triad [active] 446470016198 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 446470016199 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 446470016200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470016201 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446470016202 active site 446470016203 CoA binding site [chemical binding]; other site 446470016204 AMP binding site [chemical binding]; other site 446470016205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446470016206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446470016207 non-specific DNA binding site [nucleotide binding]; other site 446470016208 salt bridge; other site 446470016209 sequence-specific DNA binding site [nucleotide binding]; other site 446470016210 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 446470016211 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 446470016212 dimerization interface [polypeptide binding]; other site 446470016213 putative ATP binding site [chemical binding]; other site 446470016214 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446470016215 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446470016216 active site 446470016217 tetramer interface [polypeptide binding]; other site 446470016218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470016219 active site 446470016220 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446470016221 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446470016222 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446470016223 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 446470016224 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446470016225 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446470016226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470016227 Walker A motif; other site 446470016228 ATP binding site [chemical binding]; other site 446470016229 Walker B motif; other site 446470016230 arginine finger; other site 446470016231 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446470016232 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 446470016233 recombination protein RecR; Reviewed; Region: recR; PRK00076 446470016234 RecR protein; Region: RecR; pfam02132 446470016235 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446470016236 putative active site [active] 446470016237 putative metal-binding site [ion binding]; other site 446470016238 tetramer interface [polypeptide binding]; other site 446470016239 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 446470016240 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446470016241 peptide binding site [polypeptide binding]; other site 446470016242 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446470016243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470016244 dimer interface [polypeptide binding]; other site 446470016245 conserved gate region; other site 446470016246 putative PBP binding loops; other site 446470016247 ABC-ATPase subunit interface; other site 446470016248 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446470016249 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446470016250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470016251 putative PBP binding loops; other site 446470016252 dimer interface [polypeptide binding]; other site 446470016253 ABC-ATPase subunit interface; other site 446470016254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446470016255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470016256 Walker A/P-loop; other site 446470016257 ATP binding site [chemical binding]; other site 446470016258 Q-loop/lid; other site 446470016259 ABC transporter signature motif; other site 446470016260 Walker B; other site 446470016261 D-loop; other site 446470016262 H-loop/switch region; other site 446470016263 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446470016264 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446470016265 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446470016266 Walker A/P-loop; other site 446470016267 ATP binding site [chemical binding]; other site 446470016268 Q-loop/lid; other site 446470016269 ABC transporter signature motif; other site 446470016270 Walker B; other site 446470016271 D-loop; other site 446470016272 H-loop/switch region; other site 446470016273 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446470016274 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 446470016275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470016276 S-adenosylmethionine binding site [chemical binding]; other site 446470016277 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 446470016278 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446470016279 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 446470016280 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 446470016281 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470016282 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 446470016283 acyl-activating enzyme (AAE) consensus motif; other site 446470016284 acyl-activating enzyme (AAE) consensus motif; other site 446470016285 putative AMP binding site [chemical binding]; other site 446470016286 putative active site [active] 446470016287 putative CoA binding site [chemical binding]; other site 446470016288 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446470016289 CoA binding domain; Region: CoA_binding_2; pfam13380 446470016290 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446470016291 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470016292 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470016293 DNA binding residues [nucleotide binding] 446470016294 hypothetical protein; Provisional; Region: PRK06126 446470016295 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446470016296 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 446470016297 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 446470016298 active site 446470016299 octamer interface [polypeptide binding]; other site 446470016300 Cytochrome P450; Region: p450; cl12078 446470016301 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470016302 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 446470016303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470016304 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 446470016305 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446470016306 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446470016307 seryl-tRNA synthetase; Provisional; Region: PRK05431 446470016308 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470016309 motif 1; other site 446470016310 dimer interface [polypeptide binding]; other site 446470016311 active site 446470016312 motif 2; other site 446470016313 motif 3; other site 446470016314 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 446470016315 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446470016316 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446470016317 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 446470016318 putative DNA binding site [nucleotide binding]; other site 446470016319 catalytic residue [active] 446470016320 putative H2TH interface [polypeptide binding]; other site 446470016321 putative catalytic residues [active] 446470016322 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446470016323 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446470016324 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 446470016325 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446470016326 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446470016327 DNA binding residues [nucleotide binding] 446470016328 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 446470016329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446470016330 DNA binding residues [nucleotide binding] 446470016331 putative dimer interface [polypeptide binding]; other site 446470016332 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446470016333 Copper resistance protein D; Region: CopD; pfam05425 446470016334 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446470016335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470016336 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470016337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446470016338 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470016339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470016340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470016341 active site 446470016342 metal binding site [ion binding]; metal-binding site 446470016343 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 446470016344 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446470016345 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 446470016346 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446470016347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470016348 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446470016349 NAD(P) binding site [chemical binding]; other site 446470016350 active site 446470016351 Cupin; Region: Cupin_6; pfam12852 446470016352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470016353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470016354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470016355 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446470016356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470016357 S-adenosylmethionine binding site [chemical binding]; other site 446470016358 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 446470016359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446470016360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016361 Coenzyme A binding pocket [chemical binding]; other site 446470016362 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446470016363 active site 446470016364 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 446470016365 Uncharacterized conserved protein [Function unknown]; Region: COG3391 446470016366 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446470016367 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446470016368 active site 446470016369 catalytic tetrad [active] 446470016370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470016371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470016372 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446470016373 PQQ-like domain; Region: PQQ_2; pfam13360 446470016374 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 446470016375 HIT family signature motif; other site 446470016376 catalytic residue [active] 446470016377 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 446470016378 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470016379 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470016380 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 446470016381 intersubunit interface [polypeptide binding]; other site 446470016382 active site 446470016383 zinc binding site [ion binding]; other site 446470016384 Na+ binding site [ion binding]; other site 446470016385 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 446470016386 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446470016387 putative substrate binding site [chemical binding]; other site 446470016388 putative ATP binding site [chemical binding]; other site 446470016389 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 446470016390 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 446470016391 active site 446470016392 dimer interface [polypeptide binding]; other site 446470016393 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446470016394 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446470016395 nucleotide binding site [chemical binding]; other site 446470016396 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446470016397 dimer interface [polypeptide binding]; other site 446470016398 active site 446470016399 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446470016400 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446470016401 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446470016402 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446470016403 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 446470016404 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446470016405 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446470016406 catalytic center binding site [active] 446470016407 ATP binding site [chemical binding]; other site 446470016408 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 446470016409 homooctamer interface [polypeptide binding]; other site 446470016410 active site 446470016411 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446470016412 dihydropteroate synthase; Region: DHPS; TIGR01496 446470016413 substrate binding pocket [chemical binding]; other site 446470016414 dimer interface [polypeptide binding]; other site 446470016415 inhibitor binding site; inhibition site 446470016416 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446470016417 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446470016418 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 446470016419 B12 binding site [chemical binding]; other site 446470016420 cobalt ligand [ion binding]; other site 446470016421 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446470016422 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 446470016423 heme-binding site [chemical binding]; other site 446470016424 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 446470016425 FAD binding pocket [chemical binding]; other site 446470016426 conserved FAD binding motif [chemical binding]; other site 446470016427 phosphate binding motif [ion binding]; other site 446470016428 beta-alpha-beta structure motif; other site 446470016429 NAD binding pocket [chemical binding]; other site 446470016430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016431 Coenzyme A binding pocket [chemical binding]; other site 446470016432 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446470016433 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446470016434 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 446470016435 cyclase homology domain; Region: CHD; cd07302 446470016436 nucleotidyl binding site; other site 446470016437 metal binding site [ion binding]; metal-binding site 446470016438 dimer interface [polypeptide binding]; other site 446470016439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446470016440 Predicted ATPase [General function prediction only]; Region: COG3903 446470016441 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 446470016442 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 446470016443 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470016444 active site 446470016445 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446470016446 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446470016447 dimer interface [polypeptide binding]; other site 446470016448 substrate binding site [chemical binding]; other site 446470016449 metal binding sites [ion binding]; metal-binding site 446470016450 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 446470016451 Scramblase; Region: Scramblase; pfam03803 446470016452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446470016453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470016454 putative substrate translocation pore; other site 446470016455 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446470016456 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470016457 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446470016458 active site 446470016459 Int/Topo IB signature motif; other site 446470016460 DNA binding site [nucleotide binding] 446470016461 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446470016462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470016463 DNA-binding site [nucleotide binding]; DNA binding site 446470016464 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 446470016465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446470016466 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446470016467 NAD(P) binding site [chemical binding]; other site 446470016468 active site 446470016469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470016470 DNA-binding site [nucleotide binding]; DNA binding site 446470016471 Helix-turn-helix domain; Region: HTH_17; pfam12728 446470016472 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 446470016473 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 446470016474 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 446470016475 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 446470016476 replicative DNA helicase; Region: DnaB; TIGR00665 446470016477 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446470016478 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446470016479 Walker A motif; other site 446470016480 ATP binding site [chemical binding]; other site 446470016481 Walker B motif; other site 446470016482 DNA binding loops [nucleotide binding] 446470016483 Helix-turn-helix domain; Region: HTH_36; pfam13730 446470016484 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446470016485 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446470016486 cofactor binding site; other site 446470016487 DNA binding site [nucleotide binding] 446470016488 substrate interaction site [chemical binding]; other site 446470016489 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446470016490 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 446470016491 DNA methylase; Region: N6_N4_Mtase; pfam01555 446470016492 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446470016493 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 446470016494 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446470016495 TAP-like protein; Region: Abhydrolase_4; pfam08386 446470016496 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470016497 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 446470016498 Predicted transcriptional regulators [Transcription]; Region: COG1733 446470016499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470016500 dimerization interface [polypeptide binding]; other site 446470016501 putative DNA binding site [nucleotide binding]; other site 446470016502 putative Zn2+ binding site [ion binding]; other site 446470016503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446470016504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446470016505 DNA binding site [nucleotide binding] 446470016506 domain linker motif; other site 446470016507 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446470016508 putative dimerization interface [polypeptide binding]; other site 446470016509 putative ligand binding site [chemical binding]; other site 446470016510 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446470016511 beta-galactosidase; Region: BGL; TIGR03356 446470016512 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446470016513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470016514 dimer interface [polypeptide binding]; other site 446470016515 conserved gate region; other site 446470016516 putative PBP binding loops; other site 446470016517 ABC-ATPase subunit interface; other site 446470016518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446470016519 dimer interface [polypeptide binding]; other site 446470016520 conserved gate region; other site 446470016521 putative PBP binding loops; other site 446470016522 ABC-ATPase subunit interface; other site 446470016523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446470016524 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446470016525 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 446470016526 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446470016527 intersubunit interface [polypeptide binding]; other site 446470016528 PQQ-like domain; Region: PQQ_2; pfam13360 446470016529 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446470016530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470016531 ABC-ATPase subunit interface; other site 446470016532 dimer interface [polypeptide binding]; other site 446470016533 putative PBP binding regions; other site 446470016534 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446470016535 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446470016536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470016537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470016538 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470016539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470016540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470016541 Walker A/P-loop; other site 446470016542 ATP binding site [chemical binding]; other site 446470016543 Q-loop/lid; other site 446470016544 ABC transporter signature motif; other site 446470016545 Walker B; other site 446470016546 D-loop; other site 446470016547 H-loop/switch region; other site 446470016548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446470016549 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446470016550 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 446470016551 Walker A/P-loop; other site 446470016552 ATP binding site [chemical binding]; other site 446470016553 Q-loop/lid; other site 446470016554 ABC transporter signature motif; other site 446470016555 Walker B; other site 446470016556 D-loop; other site 446470016557 H-loop/switch region; other site 446470016558 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 446470016559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470016560 dimerization interface [polypeptide binding]; other site 446470016561 putative DNA binding site [nucleotide binding]; other site 446470016562 putative Zn2+ binding site [ion binding]; other site 446470016563 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446470016564 hydrophobic ligand binding site; other site 446470016565 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446470016566 Beta-lactamase; Region: Beta-lactamase; pfam00144 446470016567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446470016568 HipA N-terminal domain; Region: Couple_hipA; pfam13657 446470016569 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 446470016570 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446470016571 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446470016572 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446470016573 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446470016574 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446470016575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470016576 Walker A/P-loop; other site 446470016577 ATP binding site [chemical binding]; other site 446470016578 Q-loop/lid; other site 446470016579 ABC transporter signature motif; other site 446470016580 Walker B; other site 446470016581 D-loop; other site 446470016582 H-loop/switch region; other site 446470016583 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446470016584 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446470016585 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 446470016586 heme-binding site [chemical binding]; other site 446470016587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470016588 UMP phosphatase; Provisional; Region: PRK10444 446470016589 active site 446470016590 motif I; other site 446470016591 motif II; other site 446470016592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470016593 motif II; other site 446470016594 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 446470016595 active site 446470016596 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 446470016597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446470016598 FeS/SAM binding site; other site 446470016599 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 446470016600 putative ligand binding pocket/active site [active] 446470016601 putative metal binding site [ion binding]; other site 446470016602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470016603 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446470016604 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446470016605 dimer interface [polypeptide binding]; other site 446470016606 putative anticodon binding site; other site 446470016607 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446470016608 motif 1; other site 446470016609 dimer interface [polypeptide binding]; other site 446470016610 active site 446470016611 motif 2; other site 446470016612 motif 3; other site 446470016613 Lsr2; Region: Lsr2; pfam11774 446470016614 Clp protease ATP binding subunit; Region: clpC; CHL00095 446470016615 Clp amino terminal domain; Region: Clp_N; pfam02861 446470016616 Clp amino terminal domain; Region: Clp_N; pfam02861 446470016617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470016618 Walker A motif; other site 446470016619 ATP binding site [chemical binding]; other site 446470016620 Walker B motif; other site 446470016621 arginine finger; other site 446470016622 UvrB/uvrC motif; Region: UVR; pfam02151 446470016623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470016624 Walker A motif; other site 446470016625 ATP binding site [chemical binding]; other site 446470016626 Walker B motif; other site 446470016627 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446470016628 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 446470016629 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 446470016630 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446470016631 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446470016632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470016633 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446470016634 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446470016635 dimer interface [polypeptide binding]; other site 446470016636 putative functional site; other site 446470016637 putative MPT binding site; other site 446470016638 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 446470016639 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 446470016640 active site 446470016641 tetramer interface; other site 446470016642 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 446470016643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446470016644 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446470016645 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470016646 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470016647 metal binding site [ion binding]; metal-binding site 446470016648 active site 446470016649 I-site; other site 446470016650 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 446470016651 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 446470016652 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446470016653 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 446470016654 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446470016655 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446470016656 Walker A/P-loop; other site 446470016657 ATP binding site [chemical binding]; other site 446470016658 Q-loop/lid; other site 446470016659 ABC transporter signature motif; other site 446470016660 Walker B; other site 446470016661 D-loop; other site 446470016662 H-loop/switch region; other site 446470016663 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446470016664 dimer interface [polypeptide binding]; other site 446470016665 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446470016666 putative PBP binding regions; other site 446470016667 ABC-ATPase subunit interface; other site 446470016668 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 446470016669 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446470016670 putative binding site residues; other site 446470016671 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446470016672 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 446470016673 trimer interface [polypeptide binding]; other site 446470016674 dimer interface [polypeptide binding]; other site 446470016675 putative active site [active] 446470016676 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 446470016677 MPT binding site; other site 446470016678 trimer interface [polypeptide binding]; other site 446470016679 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446470016680 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446470016681 dimer interface [polypeptide binding]; other site 446470016682 putative functional site; other site 446470016683 putative MPT binding site; other site 446470016684 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446470016685 MoaE homodimer interface [polypeptide binding]; other site 446470016686 MoaD interaction [polypeptide binding]; other site 446470016687 active site residues [active] 446470016688 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446470016689 Cytochrome P450; Region: p450; cl12078 446470016690 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446470016691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446470016692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446470016693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470016694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446470016695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470016696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470016697 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446470016698 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 446470016699 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 446470016700 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 446470016701 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 446470016702 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 446470016703 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470016704 AAA ATPase domain; Region: AAA_16; pfam13191 446470016705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446470016706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470016707 active site 446470016708 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 446470016709 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 446470016710 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446470016711 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 446470016712 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 446470016713 putative active site [active] 446470016714 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 446470016715 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 446470016716 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446470016717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446470016718 DNA-binding site [nucleotide binding]; DNA binding site 446470016719 FCD domain; Region: FCD; pfam07729 446470016720 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446470016721 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446470016722 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446470016723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470016724 putative substrate translocation pore; other site 446470016725 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446470016726 nucleotide binding site [chemical binding]; other site 446470016727 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446470016728 SBD interface [polypeptide binding]; other site 446470016729 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 446470016730 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446470016731 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 446470016732 DNA binding residues [nucleotide binding] 446470016733 dimer interface [polypeptide binding]; other site 446470016734 [2Fe-2S] cluster binding site [ion binding]; other site 446470016735 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446470016736 TPP-binding site [chemical binding]; other site 446470016737 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 446470016738 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446470016739 PYR/PP interface [polypeptide binding]; other site 446470016740 dimer interface [polypeptide binding]; other site 446470016741 TPP binding site [chemical binding]; other site 446470016742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446470016743 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446470016744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446470016745 motif II; other site 446470016746 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446470016747 active site 2 [active] 446470016748 active site 1 [active] 446470016749 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446470016750 active site 446470016751 catalytic site [active] 446470016752 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 446470016753 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446470016754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446470016755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446470016756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446470016757 metal binding site [ion binding]; metal-binding site 446470016758 active site 446470016759 I-site; other site 446470016760 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446470016761 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446470016762 Peptidase family M23; Region: Peptidase_M23; pfam01551 446470016763 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446470016764 amidase catalytic site [active] 446470016765 Zn binding residues [ion binding]; other site 446470016766 substrate binding site [chemical binding]; other site 446470016767 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 446470016768 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 446470016769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446470016770 DNA binding site [nucleotide binding] 446470016771 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446470016772 DNA binding site [nucleotide binding] 446470016773 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446470016774 Predicted ATPase [General function prediction only]; Region: COG3903 446470016775 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446470016776 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446470016777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446470016778 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446470016779 Walker A/P-loop; other site 446470016780 ATP binding site [chemical binding]; other site 446470016781 Q-loop/lid; other site 446470016782 ABC transporter signature motif; other site 446470016783 Walker B; other site 446470016784 D-loop; other site 446470016785 H-loop/switch region; other site 446470016786 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446470016787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016788 Coenzyme A binding pocket [chemical binding]; other site 446470016789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446470016790 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 446470016791 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446470016792 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446470016793 putative acyl-acceptor binding pocket; other site 446470016794 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446470016795 active site 446470016796 fumarate hydratase; Provisional; Region: PRK15389 446470016797 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 446470016798 Fumarase C-terminus; Region: Fumerase_C; pfam05683 446470016799 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446470016800 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446470016801 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446470016802 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446470016803 Bacterial sugar transferase; Region: Bac_transf; pfam02397 446470016804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446470016805 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446470016806 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446470016807 FOG: CBS domain [General function prediction only]; Region: COG0517 446470016808 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 446470016809 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446470016810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016811 Coenzyme A binding pocket [chemical binding]; other site 446470016812 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 446470016813 Glyco_18 domain; Region: Glyco_18; smart00636 446470016814 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446470016815 active site 446470016816 hypothetical protein; Provisional; Region: PRK09256 446470016817 prephenate dehydratase; Provisional; Region: PRK11898 446470016818 Prephenate dehydratase; Region: PDT; pfam00800 446470016819 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 446470016820 putative L-Phe binding site [chemical binding]; other site 446470016821 Domain of unknown function DUF21; Region: DUF21; pfam01595 446470016822 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446470016823 FOG: CBS domain [General function prediction only]; Region: COG0517 446470016824 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446470016825 Domain of unknown function DUF21; Region: DUF21; pfam01595 446470016826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446470016827 Transporter associated domain; Region: CorC_HlyC; smart01091 446470016828 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446470016829 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 446470016830 dimerization interface [polypeptide binding]; other site 446470016831 ATP binding site [chemical binding]; other site 446470016832 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 446470016833 dimerization interface [polypeptide binding]; other site 446470016834 ATP binding site [chemical binding]; other site 446470016835 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 446470016836 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446470016837 putative active site [active] 446470016838 catalytic triad [active] 446470016839 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 446470016840 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446470016841 Lyase; Region: Lyase_1; pfam00206 446470016842 tetramer interface [polypeptide binding]; other site 446470016843 BCCT family transporter; Region: BCCT; pfam02028 446470016844 sugar efflux transporter; Region: 2A0120; TIGR00899 446470016845 Predicted integral membrane protein [Function unknown]; Region: COG5650 446470016846 endonuclease IV; Provisional; Region: PRK01060 446470016847 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 446470016848 AP (apurinic/apyrimidinic) site pocket; other site 446470016849 DNA interaction; other site 446470016850 Metal-binding active site; metal-binding site 446470016851 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446470016852 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446470016853 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446470016854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446470016855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446470016856 active site 446470016857 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446470016858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446470016859 dimerization interface [polypeptide binding]; other site 446470016860 putative DNA binding site [nucleotide binding]; other site 446470016861 putative Zn2+ binding site [ion binding]; other site 446470016862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446470016863 active site 446470016864 classical (c) SDRs; Region: SDR_c; cd05233 446470016865 NAD(P) binding site [chemical binding]; other site 446470016866 active site 446470016867 Interferon-induced transmembrane protein; Region: CD225; pfam04505 446470016868 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 446470016869 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 446470016870 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446470016871 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446470016872 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446470016873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446470016874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446470016875 homodimer interface [polypeptide binding]; other site 446470016876 catalytic residue [active] 446470016877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446470016878 NIPSNAP; Region: NIPSNAP; pfam07978 446470016879 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446470016880 catalytic residues [active] 446470016881 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446470016882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446470016883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446470016884 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 446470016885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446470016886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446470016887 DNA binding residues [nucleotide binding] 446470016888 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446470016889 active site 446470016890 ATP binding site [chemical binding]; other site 446470016891 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 446470016892 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 446470016893 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 446470016894 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446470016895 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446470016896 active site 446470016897 NTP binding site [chemical binding]; other site 446470016898 metal binding triad [ion binding]; metal-binding site 446470016899 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446470016900 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446470016901 Zn2+ binding site [ion binding]; other site 446470016902 Mg2+ binding site [ion binding]; other site 446470016903 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 446470016904 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446470016905 substrate binding site [chemical binding]; other site 446470016906 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 446470016907 Phosphotransferase enzyme family; Region: APH; pfam01636 446470016908 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446470016909 active site 446470016910 ATP binding site [chemical binding]; other site 446470016911 substrate binding site [chemical binding]; other site 446470016912 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 446470016913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446470016914 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446470016915 haloalkane dehalogenase; Provisional; Region: PRK03592 446470016916 arginine deiminase; Provisional; Region: PRK01388 446470016917 MarR family; Region: MarR_2; pfam12802 446470016918 Chitin binding Peritrophin-A domain; Region: CBM_14; pfam01607 446470016919 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446470016920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446470016921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446470016922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446470016923 putative substrate translocation pore; other site 446470016924 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446470016925 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 446470016926 acyl-activating enzyme (AAE) consensus motif; other site 446470016927 AMP binding site [chemical binding]; other site 446470016928 active site 446470016929 CoA binding site [chemical binding]; other site 446470016930 PaaX-like protein; Region: PaaX; pfam07848 446470016931 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 446470016932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446470016933 classical (c) SDRs; Region: SDR_c; cd05233 446470016934 NAD(P) binding site [chemical binding]; other site 446470016935 active site 446470016936 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446470016937 Clp amino terminal domain; Region: Clp_N; pfam02861 446470016938 Clp amino terminal domain; Region: Clp_N; pfam02861 446470016939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470016940 Walker A motif; other site 446470016941 ATP binding site [chemical binding]; other site 446470016942 Walker B motif; other site 446470016943 arginine finger; other site 446470016944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446470016945 Walker A motif; other site 446470016946 ATP binding site [chemical binding]; other site 446470016947 Walker B motif; other site 446470016948 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446470016949 Predicted membrane protein [Function unknown]; Region: COG2119 446470016950 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 446470016951 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 446470016952 hypothetical protein; Provisional; Region: PRK04194 446470016953 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 446470016954 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 446470016955 AIR carboxylase; Region: AIRC; smart01001 446470016956 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446470016957 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446470016958 active site 446470016959 catalytic site [active] 446470016960 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446470016961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446470016962 ATP binding site [chemical binding]; other site 446470016963 Mg2+ binding site [ion binding]; other site 446470016964 G-X-G motif; other site 446470016965 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 446470016966 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 446470016967 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 446470016968 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 446470016969 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446470016970 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470016971 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446470016972 active site 446470016973 ATP binding site [chemical binding]; other site 446470016974 substrate binding site [chemical binding]; other site 446470016975 activation loop (A-loop); other site 446470016976 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470016977 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470016978 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446470016979 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446470016980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446470016981 active site 446470016982 ATP binding site [chemical binding]; other site 446470016983 substrate binding site [chemical binding]; other site 446470016984 activation loop (A-loop); other site 446470016985 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446470016986 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446470016987 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446470016988 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 446470016989 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446470016990 active site 446470016991 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446470016992 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446470016993 phosphopeptide binding site; other site 446470016994 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446470016995 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446470016996 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446470016997 phosphopeptide binding site; other site 446470016998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446470016999 Coenzyme A binding pocket [chemical binding]; other site 446470017000 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446470017001 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 446470017002 ParB-like nuclease domain; Region: ParB; smart00470 446470017003 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446470017004 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446470017005 P-loop; other site 446470017006 Magnesium ion binding site [ion binding]; other site 446470017007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446470017008 Magnesium ion binding site [ion binding]; other site 446470017009 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 446470017010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446470017011 S-adenosylmethionine binding site [chemical binding]; other site 446470017012 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 446470017013 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446470017014 G-X-X-G motif; other site 446470017015 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446470017016 RxxxH motif; other site 446470017017 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446470017018 Haemolytic domain; Region: Haemolytic; pfam01809 446470017019 Ribonuclease P; Region: Ribonuclease_P; cl00457 446470017020 Ribosomal protein L34; Region: Ribosomal_L34; cl00370