-- dump date   	20140620_073012
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
111780000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
111780000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
111780000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780000004	Walker A motif; other site
111780000005	ATP binding site [chemical binding]; other site
111780000006	Walker B motif; other site
111780000007	arginine finger; other site
111780000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
111780000009	DnaA box-binding interface [nucleotide binding]; other site
111780000010	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
111780000011	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
111780000012	metal ion-dependent adhesion site (MIDAS); other site
111780000013	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
111780000014	Calx-beta domain; Region: Calx-beta; cl02522
111780000015	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780000016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000017	active site
111780000018	phosphorylation site [posttranslational modification]
111780000019	intermolecular recognition site; other site
111780000020	dimerization interface [polypeptide binding]; other site
111780000021	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780000022	DNA binding site [nucleotide binding]
111780000023	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
111780000024	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
111780000025	Walker A/P-loop; other site
111780000026	ATP binding site [chemical binding]; other site
111780000027	Q-loop/lid; other site
111780000028	ABC transporter signature motif; other site
111780000029	Walker B; other site
111780000030	D-loop; other site
111780000031	H-loop/switch region; other site
111780000032	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
111780000033	PHP domain; Region: PHP; pfam02811
111780000034	active site
111780000035	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780000036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000037	active site
111780000038	phosphorylation site [posttranslational modification]
111780000039	intermolecular recognition site; other site
111780000040	dimerization interface [polypeptide binding]; other site
111780000041	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780000042	DNA binding residues [nucleotide binding]
111780000043	dimerization interface [polypeptide binding]; other site
111780000044	calcium/proton exchanger (cax); Region: cax; TIGR00378
111780000045	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
111780000046	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
111780000047	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
111780000048	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
111780000049	Competence protein; Region: Competence; pfam03772
111780000050	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
111780000051	Uncharacterized conserved protein [Function unknown]; Region: COG2442
111780000052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
111780000053	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
111780000054	Creatinine amidohydrolase; Region: Creatininase; pfam02633
111780000055	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
111780000056	Helix-turn-helix domain; Region: HTH_25; pfam13413
111780000057	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
111780000058	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
111780000059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
111780000060	RNA binding surface [nucleotide binding]; other site
111780000061	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
111780000062	active site
111780000063	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
111780000064	threonine synthase; Validated; Region: PRK07591
111780000065	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
111780000066	homodimer interface [polypeptide binding]; other site
111780000067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780000068	catalytic residue [active]
111780000069	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
111780000070	MoaE interaction surface [polypeptide binding]; other site
111780000071	MoeB interaction surface [polypeptide binding]; other site
111780000072	thiocarboxylated glycine; other site
111780000073	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
111780000074	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
111780000075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780000076	dimer interface [polypeptide binding]; other site
111780000077	conserved gate region; other site
111780000078	putative PBP binding loops; other site
111780000079	ABC-ATPase subunit interface; other site
111780000080	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
111780000081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780000082	S-adenosylmethionine binding site [chemical binding]; other site
111780000083	LabA_like proteins; Region: LabA_like; cd06167
111780000084	putative metal binding site [ion binding]; other site
111780000085	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
111780000086	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
111780000087	NAD(P) binding site [chemical binding]; other site
111780000088	catalytic residues [active]
111780000089	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
111780000090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780000091	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
111780000092	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
111780000093	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780000094	active site
111780000095	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
111780000096	PAS fold; Region: PAS_4; pfam08448
111780000097	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780000098	putative active site [active]
111780000099	heme pocket [chemical binding]; other site
111780000100	PAS domain S-box; Region: sensory_box; TIGR00229
111780000101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780000102	putative active site [active]
111780000103	heme pocket [chemical binding]; other site
111780000104	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780000105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780000106	metal binding site [ion binding]; metal-binding site
111780000107	active site
111780000108	I-site; other site
111780000109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780000110	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
111780000111	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
111780000112	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
111780000113	MgtE intracellular N domain; Region: MgtE_N; smart00924
111780000114	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
111780000115	Divalent cation transporter; Region: MgtE; pfam01769
111780000116	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
111780000117	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
111780000118	nucleotide binding site/active site [active]
111780000119	HIT family signature motif; other site
111780000120	catalytic residue [active]
111780000121	ATP adenylyltransferase; Region: ATP_transf; pfam09830
111780000122	Response regulator receiver domain; Region: Response_reg; pfam00072
111780000123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000124	active site
111780000125	phosphorylation site [posttranslational modification]
111780000126	intermolecular recognition site; other site
111780000127	dimerization interface [polypeptide binding]; other site
111780000128	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
111780000129	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
111780000130	LabA_like proteins; Region: LabA_like; cd06167
111780000131	putative metal binding site [ion binding]; other site
111780000132	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
111780000133	PhoH-like protein; Region: PhoH; pfam02562
111780000134	Thymidylate synthase complementing protein; Region: Thy1; cl03630
111780000135	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
111780000136	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
111780000137	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
111780000138	putative active site [active]
111780000139	putative NTP binding site [chemical binding]; other site
111780000140	putative nucleic acid binding site [nucleotide binding]; other site
111780000141	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
111780000142	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
111780000143	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
111780000144	active site
111780000145	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
111780000146	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
111780000147	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
111780000148	putative active site [active]
111780000149	putative NTP binding site [chemical binding]; other site
111780000150	putative nucleic acid binding site [nucleotide binding]; other site
111780000151	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
111780000152	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
111780000153	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
111780000154	active site
111780000155	Response regulator receiver domain; Region: Response_reg; pfam00072
111780000156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000157	active site
111780000158	phosphorylation site [posttranslational modification]
111780000159	intermolecular recognition site; other site
111780000160	dimerization interface [polypeptide binding]; other site
111780000161	PAS domain; Region: PAS_9; pfam13426
111780000162	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780000163	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780000164	metal binding site [ion binding]; metal-binding site
111780000165	active site
111780000166	I-site; other site
111780000167	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780000168	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780000169	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
111780000170	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
111780000171	active site
111780000172	HIGH motif; other site
111780000173	KMSKS motif; other site
111780000174	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
111780000175	anticodon binding site; other site
111780000176	tRNA binding surface [nucleotide binding]; other site
111780000177	Uncharacterized conserved protein [Function unknown]; Region: COG1432
111780000178	LabA_like proteins; Region: LabA; cd10911
111780000179	putative metal binding site [ion binding]; other site
111780000180	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
111780000181	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
111780000182	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
111780000183	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
111780000184	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
111780000185	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
111780000186	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
111780000187	active site
111780000188	dimer interface [polypeptide binding]; other site
111780000189	motif 1; other site
111780000190	motif 2; other site
111780000191	motif 3; other site
111780000192	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
111780000193	anticodon binding site; other site
111780000194	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
111780000195	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
111780000196	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
111780000197	putative active site [active]
111780000198	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
111780000199	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780000200	ATP binding site [chemical binding]; other site
111780000201	putative Mg++ binding site [ion binding]; other site
111780000202	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780000203	nucleotide binding region [chemical binding]; other site
111780000204	ATP-binding site [chemical binding]; other site
111780000205	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
111780000206	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
111780000207	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
111780000208	ABC-ATPase subunit  interface; other site
111780000209	dimer interface [polypeptide binding]; other site
111780000210	putative PBP binding regions; other site
111780000211	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
111780000212	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
111780000213	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
111780000214	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
111780000215	intersubunit interface [polypeptide binding]; other site
111780000216	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780000217	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
111780000218	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
111780000219	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
111780000220	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
111780000221	HIGH motif; other site
111780000222	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
111780000223	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
111780000224	active site
111780000225	KMSKS motif; other site
111780000226	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
111780000227	tRNA binding surface [nucleotide binding]; other site
111780000228	anticodon binding site; other site
111780000229	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
111780000230	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
111780000231	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780000232	cofactor binding site; other site
111780000233	DNA binding site [nucleotide binding]
111780000234	substrate interaction site [chemical binding]; other site
111780000235	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
111780000236	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
111780000237	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
111780000238	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
111780000239	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
111780000240	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
111780000241	dimer interface [polypeptide binding]; other site
111780000242	FMN binding site [chemical binding]; other site
111780000243	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
111780000244	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
111780000245	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
111780000246	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
111780000247	Mechanosensitive ion channel; Region: MS_channel; pfam00924
111780000248	RNA polymerase sigma factor; Validated; Region: PRK05949
111780000249	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
111780000250	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780000251	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780000252	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780000253	DNA binding residues [nucleotide binding]
111780000254	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
111780000255	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
111780000256	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
111780000257	substrate-cofactor binding pocket; other site
111780000258	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780000259	catalytic residue [active]
111780000260	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780000261	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780000262	active site
111780000263	catalytic tetrad [active]
111780000264	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
111780000265	PemK-like protein; Region: PemK; cl00995
111780000266	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
111780000267	Flavoprotein; Region: Flavoprotein; pfam02441
111780000268	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
111780000269	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
111780000270	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
111780000271	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
111780000272	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780000273	Coenzyme A binding pocket [chemical binding]; other site
111780000274	membrane protein; Provisional; Region: PRK14419
111780000275	MgtC family; Region: MgtC; pfam02308
111780000276	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
111780000277	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
111780000278	short chain dehydrogenase; Provisional; Region: PRK06701
111780000279	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780000280	NAD(P) binding site [chemical binding]; other site
111780000281	active site
111780000282	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
111780000283	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
111780000284	dimer interface [polypeptide binding]; other site
111780000285	motif 1; other site
111780000286	active site
111780000287	motif 2; other site
111780000288	motif 3; other site
111780000289	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
111780000290	anticodon binding site; other site
111780000291	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
111780000292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780000293	Walker A/P-loop; other site
111780000294	ATP binding site [chemical binding]; other site
111780000295	Q-loop/lid; other site
111780000296	ABC transporter signature motif; other site
111780000297	Walker B; other site
111780000298	D-loop; other site
111780000299	H-loop/switch region; other site
111780000300	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
111780000301	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
111780000302	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
111780000303	SLBB domain; Region: SLBB; pfam10531
111780000304	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
111780000305	SLBB domain; Region: SLBB; pfam10531
111780000306	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780000307	Chain length determinant protein; Region: Wzz; pfam02706
111780000308	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780000309	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780000310	Magnesium ion binding site [ion binding]; other site
111780000311	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
111780000312	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
111780000313	GAF domain; Region: GAF; cl17456
111780000314	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780000315	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780000316	dimer interface [polypeptide binding]; other site
111780000317	phosphorylation site [posttranslational modification]
111780000318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780000319	ATP binding site [chemical binding]; other site
111780000320	Mg2+ binding site [ion binding]; other site
111780000321	G-X-G motif; other site
111780000322	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
111780000323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780000324	dimer interface [polypeptide binding]; other site
111780000325	conserved gate region; other site
111780000326	putative PBP binding loops; other site
111780000327	ABC-ATPase subunit interface; other site
111780000328	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
111780000329	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780000330	dimerization interface [polypeptide binding]; other site
111780000331	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780000332	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780000333	active site
111780000334	ATP binding site [chemical binding]; other site
111780000335	substrate binding site [chemical binding]; other site
111780000336	activation loop (A-loop); other site
111780000337	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780000338	phosphopeptide binding site; other site
111780000339	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780000340	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780000341	phosphopeptide binding site; other site
111780000342	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
111780000343	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
111780000344	Walker A/P-loop; other site
111780000345	ATP binding site [chemical binding]; other site
111780000346	Q-loop/lid; other site
111780000347	ABC transporter signature motif; other site
111780000348	Walker B; other site
111780000349	D-loop; other site
111780000350	H-loop/switch region; other site
111780000351	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
111780000352	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780000353	active site
111780000354	ATP binding site [chemical binding]; other site
111780000355	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780000356	substrate binding site [chemical binding]; other site
111780000357	activation loop (A-loop); other site
111780000358	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
111780000359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780000360	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
111780000361	putative dimerization interface [polypeptide binding]; other site
111780000362	Predicted membrane protein [Function unknown]; Region: COG4094
111780000363	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
111780000364	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780000365	catalytic residues [active]
111780000366	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
111780000367	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
111780000368	Walker A/P-loop; other site
111780000369	ATP binding site [chemical binding]; other site
111780000370	Q-loop/lid; other site
111780000371	ABC transporter signature motif; other site
111780000372	Walker B; other site
111780000373	D-loop; other site
111780000374	H-loop/switch region; other site
111780000375	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
111780000376	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
111780000377	tellurium resistance terB-like protein; Region: terB_like; cd07177
111780000378	metal binding site [ion binding]; metal-binding site
111780000379	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
111780000380	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
111780000381	putative active site [active]
111780000382	catalytic site [active]
111780000383	putative metal binding site [ion binding]; other site
111780000384	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
111780000385	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780000386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780000387	binding surface
111780000388	TPR motif; other site
111780000389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780000390	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780000391	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
111780000392	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
111780000393	TM-ABC transporter signature motif; other site
111780000394	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780000395	putative active site [active]
111780000396	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
111780000397	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
111780000398	active site
111780000399	KGK domain; Region: KGK; pfam08872
111780000400	KGK domain; Region: KGK; pfam08872
111780000401	KGK domain; Region: KGK; pfam08872
111780000402	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
111780000403	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
111780000404	Cl- selectivity filter; other site
111780000405	Cl- binding residues [ion binding]; other site
111780000406	pore gating glutamate residue; other site
111780000407	dimer interface [polypeptide binding]; other site
111780000408	H+/Cl- coupling transport residue; other site
111780000409	FOG: CBS domain [General function prediction only]; Region: COG0517
111780000410	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
111780000411	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
111780000412	Ligand Binding Site [chemical binding]; other site
111780000413	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780000414	Ligand Binding Site [chemical binding]; other site
111780000415	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
111780000416	Ferritin-like domain; Region: Ferritin; pfam00210
111780000417	dinuclear metal binding motif [ion binding]; other site
111780000418	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
111780000419	classical (c) SDRs; Region: SDR_c; cd05233
111780000420	NAD(P) binding site [chemical binding]; other site
111780000421	active site
111780000422	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
111780000423	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780000424	NAD(P) binding site [chemical binding]; other site
111780000425	active site
111780000426	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
111780000427	CheB methylesterase; Region: CheB_methylest; pfam01339
111780000428	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
111780000429	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
111780000430	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
111780000431	PAS domain; Region: PAS_9; pfam13426
111780000432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780000433	putative active site [active]
111780000434	heme pocket [chemical binding]; other site
111780000435	PAS fold; Region: PAS; pfam00989
111780000436	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780000437	putative active site [active]
111780000438	heme pocket [chemical binding]; other site
111780000439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780000440	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780000441	putative active site [active]
111780000442	heme pocket [chemical binding]; other site
111780000443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780000444	histidine kinase; Provisional; Region: PRK13557
111780000445	putative active site [active]
111780000446	heme pocket [chemical binding]; other site
111780000447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780000448	dimer interface [polypeptide binding]; other site
111780000449	phosphorylation site [posttranslational modification]
111780000450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780000451	ATP binding site [chemical binding]; other site
111780000452	Mg2+ binding site [ion binding]; other site
111780000453	G-X-G motif; other site
111780000454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000455	active site
111780000456	phosphorylation site [posttranslational modification]
111780000457	intermolecular recognition site; other site
111780000458	dimerization interface [polypeptide binding]; other site
111780000459	Hemerythrin-like domain; Region: Hr-like; cd12108
111780000460	Fe binding site [ion binding]; other site
111780000461	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
111780000462	oxyanion hole [active]
111780000463	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
111780000464	Low molecular weight phosphatase family; Region: LMWPc; cd00115
111780000465	active site
111780000466	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
111780000467	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
111780000468	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
111780000469	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
111780000470	Cupin domain; Region: Cupin_2; cl17218
111780000471	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
111780000472	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
111780000473	dimer interface [polypeptide binding]; other site
111780000474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780000475	catalytic residue [active]
111780000476	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
111780000477	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
111780000478	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
111780000479	dimer interface [polypeptide binding]; other site
111780000480	decamer (pentamer of dimers) interface [polypeptide binding]; other site
111780000481	catalytic triad [active]
111780000482	FtsH Extracellular; Region: FtsH_ext; pfam06480
111780000483	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
111780000484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780000485	Walker A motif; other site
111780000486	ATP binding site [chemical binding]; other site
111780000487	Walker B motif; other site
111780000488	arginine finger; other site
111780000489	Peptidase family M41; Region: Peptidase_M41; pfam01434
111780000490	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
111780000491	ATP-NAD kinase; Region: NAD_kinase; pfam01513
111780000492	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780000493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000494	active site
111780000495	phosphorylation site [posttranslational modification]
111780000496	intermolecular recognition site; other site
111780000497	dimerization interface [polypeptide binding]; other site
111780000498	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780000499	DNA binding site [nucleotide binding]
111780000500	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
111780000501	GTPase RsgA; Reviewed; Region: PRK12289
111780000502	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
111780000503	RNA binding site [nucleotide binding]; other site
111780000504	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
111780000505	GTPase/Zn-binding domain interface [polypeptide binding]; other site
111780000506	GTP/Mg2+ binding site [chemical binding]; other site
111780000507	G4 box; other site
111780000508	G5 box; other site
111780000509	G1 box; other site
111780000510	Switch I region; other site
111780000511	G2 box; other site
111780000512	G3 box; other site
111780000513	Switch II region; other site
111780000514	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
111780000515	CPxP  motif; other site
111780000516	chaperone protein DnaJ; Provisional; Region: PRK14293
111780000517	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780000518	HSP70 interaction site [polypeptide binding]; other site
111780000519	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
111780000520	substrate binding site [polypeptide binding]; other site
111780000521	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
111780000522	Zn binding sites [ion binding]; other site
111780000523	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
111780000524	dimer interface [polypeptide binding]; other site
111780000525	molecular chaperone DnaK; Provisional; Region: PRK13411
111780000526	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
111780000527	nucleotide binding site [chemical binding]; other site
111780000528	NEF interaction site [polypeptide binding]; other site
111780000529	SBD interface [polypeptide binding]; other site
111780000530	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
111780000531	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
111780000532	dimer interface [polypeptide binding]; other site
111780000533	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
111780000534	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
111780000535	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
111780000536	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
111780000537	Walker A motif; other site
111780000538	ATP binding site [chemical binding]; other site
111780000539	Walker B motif; other site
111780000540	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780000541	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
111780000542	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
111780000543	Walker A motif; other site
111780000544	ATP binding site [chemical binding]; other site
111780000545	Walker B motif; other site
111780000546	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
111780000547	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
111780000548	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
111780000549	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
111780000550	elongation factor G; Reviewed; Region: PRK12740
111780000551	G1 box; other site
111780000552	putative GEF interaction site [polypeptide binding]; other site
111780000553	GTP/Mg2+ binding site [chemical binding]; other site
111780000554	Switch I region; other site
111780000555	G2 box; other site
111780000556	G3 box; other site
111780000557	Switch II region; other site
111780000558	G4 box; other site
111780000559	G5 box; other site
111780000560	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
111780000561	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
111780000562	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
111780000563	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
111780000564	RNA binding surface [nucleotide binding]; other site
111780000565	PRC-barrel domain; Region: PRC; pfam05239
111780000566	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
111780000567	Double zinc ribbon; Region: DZR; pfam12773
111780000568	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
111780000569	Uncharacterized conserved protein [Function unknown]; Region: COG3937
111780000570	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780000571	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780000572	phosphopeptide binding site; other site
111780000573	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
111780000574	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
111780000575	RNA binding surface [nucleotide binding]; other site
111780000576	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
111780000577	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
111780000578	ATP-binding site [chemical binding]; other site
111780000579	Gluconate-6-phosphate binding site [chemical binding]; other site
111780000580	Shikimate kinase; Region: SKI; pfam01202
111780000581	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780000582	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000583	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000584	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000585	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000586	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000587	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000588	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000589	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
111780000590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780000591	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
111780000592	active site
111780000593	metal binding site [ion binding]; metal-binding site
111780000594	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
111780000595	Glucose inhibited division protein A; Region: GIDA; pfam01134
111780000596	Ion channel; Region: Ion_trans_2; pfam07885
111780000597	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
111780000598	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
111780000599	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
111780000600	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
111780000601	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
111780000602	NADH(P)-binding; Region: NAD_binding_10; pfam13460
111780000603	NAD(P) binding site [chemical binding]; other site
111780000604	putative active site [active]
111780000605	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
111780000606	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
111780000607	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780000608	catalytic residue [active]
111780000609	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780000610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780000611	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
111780000612	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
111780000613	metal binding site [ion binding]; metal-binding site
111780000614	dimer interface [polypeptide binding]; other site
111780000615	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
111780000616	active site
111780000617	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
111780000618	ABC1 family; Region: ABC1; cl17513
111780000619	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
111780000620	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
111780000621	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
111780000622	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
111780000623	Response regulator receiver domain; Region: Response_reg; pfam00072
111780000624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000625	active site
111780000626	phosphorylation site [posttranslational modification]
111780000627	intermolecular recognition site; other site
111780000628	dimerization interface [polypeptide binding]; other site
111780000629	Response regulator receiver domain; Region: Response_reg; pfam00072
111780000630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000631	active site
111780000632	phosphorylation site [posttranslational modification]
111780000633	intermolecular recognition site; other site
111780000634	dimerization interface [polypeptide binding]; other site
111780000635	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
111780000636	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
111780000637	G1 box; other site
111780000638	GTP/Mg2+ binding site [chemical binding]; other site
111780000639	Switch I region; other site
111780000640	G2 box; other site
111780000641	Switch II region; other site
111780000642	G3 box; other site
111780000643	G4 box; other site
111780000644	G5 box; other site
111780000645	Domain of unknown function (DUF697); Region: DUF697; pfam05128
111780000646	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
111780000647	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
111780000648	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
111780000649	putative dimer interface [polypeptide binding]; other site
111780000650	N-terminal domain interface [polypeptide binding]; other site
111780000651	putative substrate binding pocket (H-site) [chemical binding]; other site
111780000652	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
111780000653	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
111780000654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780000655	S-adenosylmethionine binding site [chemical binding]; other site
111780000656	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
111780000657	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
111780000658	active site
111780000659	catalytic residues [active]
111780000660	metal binding site [ion binding]; metal-binding site
111780000661	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
111780000662	Mg chelatase-related protein; Region: TIGR00368
111780000663	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
111780000664	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780000665	Walker A motif; other site
111780000666	ATP binding site [chemical binding]; other site
111780000667	Walker B motif; other site
111780000668	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
111780000669	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
111780000670	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
111780000671	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780000672	active site
111780000673	NTP binding site [chemical binding]; other site
111780000674	metal binding triad [ion binding]; metal-binding site
111780000675	antibiotic binding site [chemical binding]; other site
111780000676	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
111780000677	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
111780000678	acyl-activating enzyme (AAE) consensus motif; other site
111780000679	putative AMP binding site [chemical binding]; other site
111780000680	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780000681	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
111780000682	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
111780000683	active site
111780000684	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
111780000685	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
111780000686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780000687	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
111780000688	Enoylreductase; Region: PKS_ER; smart00829
111780000689	NAD(P) binding site [chemical binding]; other site
111780000690	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
111780000691	KR domain; Region: KR; pfam08659
111780000692	putative NADP binding site [chemical binding]; other site
111780000693	active site
111780000694	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
111780000695	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
111780000696	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
111780000697	active site
111780000698	catalytic residues [active]
111780000699	metal binding site [ion binding]; metal-binding site
111780000700	BON domain; Region: BON; pfam04972
111780000701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
111780000702	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
111780000703	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780000704	P-loop; other site
111780000705	Magnesium ion binding site [ion binding]; other site
111780000706	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
111780000707	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
111780000708	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
111780000709	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
111780000710	glutamine binding [chemical binding]; other site
111780000711	catalytic triad [active]
111780000712	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
111780000713	metal-binding heat shock protein; Provisional; Region: PRK00016
111780000714	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
111780000715	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
111780000716	Haemolytic domain; Region: Haemolytic; pfam01809
111780000717	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
111780000718	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
111780000719	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
111780000720	active sites [active]
111780000721	tetramer interface [polypeptide binding]; other site
111780000722	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
111780000723	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
111780000724	acyl-activating enzyme (AAE) consensus motif; other site
111780000725	putative AMP binding site [chemical binding]; other site
111780000726	putative active site [active]
111780000727	putative CoA binding site [chemical binding]; other site
111780000728	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
111780000729	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
111780000730	PYR/PP interface [polypeptide binding]; other site
111780000731	dimer interface [polypeptide binding]; other site
111780000732	TPP binding site [chemical binding]; other site
111780000733	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
111780000734	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
111780000735	TPP-binding site [chemical binding]; other site
111780000736	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
111780000737	four helix bundle protein; Region: TIGR02436
111780000738	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
111780000739	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
111780000740	active site
111780000741	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
111780000742	homotrimer interaction site [polypeptide binding]; other site
111780000743	active site
111780000744	arogenate dehydrogenase; Region: PLN02256
111780000745	Prephenate dehydrogenase; Region: PDH; pfam02153
111780000746	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
111780000747	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780000748	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780000749	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
111780000750	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
111780000751	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780000752	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
111780000753	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
111780000754	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
111780000755	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780000756	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
111780000757	Ligand binding site; other site
111780000758	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
111780000759	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
111780000760	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
111780000761	shikimate binding site; other site
111780000762	NAD(P) binding site [chemical binding]; other site
111780000763	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
111780000764	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
111780000765	putative ligand binding site [chemical binding]; other site
111780000766	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
111780000767	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
111780000768	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
111780000769	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
111780000770	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
111780000771	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780000772	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
111780000773	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
111780000774	FAD binding domain; Region: FAD_binding_4; pfam01565
111780000775	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
111780000776	hypothetical protein; Validated; Region: PRK00153
111780000777	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
111780000778	E-class dimer interface [polypeptide binding]; other site
111780000779	P-class dimer interface [polypeptide binding]; other site
111780000780	active site
111780000781	Cu2+ binding site [ion binding]; other site
111780000782	Zn2+ binding site [ion binding]; other site
111780000783	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
111780000784	Aspartase; Region: Aspartase; cd01357
111780000785	active sites [active]
111780000786	tetramer interface [polypeptide binding]; other site
111780000787	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
111780000788	CpeS-like protein; Region: CpeS; pfam09367
111780000789	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
111780000790	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
111780000791	Phycobilisome protein; Region: Phycobilisome; cl08227
111780000792	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
111780000793	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780000794	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780000795	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780000796	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780000797	HEAT repeats; Region: HEAT_2; pfam13646
111780000798	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
111780000799	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
111780000800	HEAT repeats; Region: HEAT_2; pfam13646
111780000801	HEAT repeats; Region: HEAT_2; pfam13646
111780000802	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780000803	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
111780000804	Probable transposase; Region: OrfB_IS605; pfam01385
111780000805	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780000806	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
111780000807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780000808	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
111780000809	RNA polymerase factor sigma-70; Validated; Region: PRK06811
111780000810	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
111780000811	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
111780000812	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780000813	heat shock protein 90; Provisional; Region: PRK05218
111780000814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780000815	ATP binding site [chemical binding]; other site
111780000816	Mg2+ binding site [ion binding]; other site
111780000817	G-X-G motif; other site
111780000818	Domain of unknown function (DUF389); Region: DUF389; pfam04087
111780000819	ribonuclease Z; Region: RNase_Z; TIGR02651
111780000820	Stage II sporulation protein; Region: SpoIID; pfam08486
111780000821	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
111780000822	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
111780000823	Probable transposase; Region: OrfB_IS605; pfam01385
111780000824	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780000825	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780000826	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
111780000827	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780000828	HSP70 interaction site [polypeptide binding]; other site
111780000829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780000830	binding surface
111780000831	TPR motif; other site
111780000832	TPR repeat; Region: TPR_11; pfam13414
111780000833	H+ Antiporter protein; Region: 2A0121; TIGR00900
111780000834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780000835	putative substrate translocation pore; other site
111780000836	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780000837	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
111780000838	triosephosphate isomerase; Provisional; Region: PRK14565
111780000839	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
111780000840	substrate binding site [chemical binding]; other site
111780000841	dimer interface [polypeptide binding]; other site
111780000842	catalytic triad [active]
111780000843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780000844	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
111780000845	non-specific DNA binding site [nucleotide binding]; other site
111780000846	salt bridge; other site
111780000847	sequence-specific DNA binding site [nucleotide binding]; other site
111780000848	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
111780000849	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
111780000850	photosystem II subunit S (PsbS); Provisional; Region: PLN00084
111780000851	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
111780000852	MutS domain III; Region: MutS_III; pfam05192
111780000853	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
111780000854	Walker A/P-loop; other site
111780000855	ATP binding site [chemical binding]; other site
111780000856	Q-loop/lid; other site
111780000857	ABC transporter signature motif; other site
111780000858	Walker B; other site
111780000859	D-loop; other site
111780000860	H-loop/switch region; other site
111780000861	Smr domain; Region: Smr; pfam01713
111780000862	TonB C terminal; Region: TonB_2; pfam13103
111780000863	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
111780000864	Mechanosensitive ion channel; Region: MS_channel; pfam00924
111780000865	Predicted membrane protein [Function unknown]; Region: COG4325
111780000866	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
111780000867	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
111780000868	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
111780000869	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
111780000870	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
111780000871	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780000872	catalytic residues [active]
111780000873	adenylosuccinate lyase; Provisional; Region: PRK07380
111780000874	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
111780000875	tetramer interface [polypeptide binding]; other site
111780000876	active site
111780000877	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
111780000878	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
111780000879	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
111780000880	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
111780000881	active site residue [active]
111780000882	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
111780000883	active site residue [active]
111780000884	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
111780000885	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
111780000886	putative active site [active]
111780000887	metal binding site [ion binding]; metal-binding site
111780000888	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
111780000889	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780000890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000891	active site
111780000892	phosphorylation site [posttranslational modification]
111780000893	intermolecular recognition site; other site
111780000894	dimerization interface [polypeptide binding]; other site
111780000895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780000896	DNA binding site [nucleotide binding]
111780000897	Hpt domain; Region: Hpt; pfam01627
111780000898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000899	Response regulator receiver domain; Region: Response_reg; pfam00072
111780000900	active site
111780000901	phosphorylation site [posttranslational modification]
111780000902	intermolecular recognition site; other site
111780000903	dimerization interface [polypeptide binding]; other site
111780000904	Response regulator receiver domain; Region: Response_reg; pfam00072
111780000905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000906	active site
111780000907	phosphorylation site [posttranslational modification]
111780000908	intermolecular recognition site; other site
111780000909	dimerization interface [polypeptide binding]; other site
111780000910	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780000911	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780000912	metal binding site [ion binding]; metal-binding site
111780000913	active site
111780000914	I-site; other site
111780000915	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
111780000916	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
111780000917	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
111780000918	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
111780000919	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780000920	DNA polymerase I; Provisional; Region: PRK05755
111780000921	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
111780000922	active site
111780000923	metal binding site 1 [ion binding]; metal-binding site
111780000924	putative 5' ssDNA interaction site; other site
111780000925	metal binding site 3; metal-binding site
111780000926	metal binding site 2 [ion binding]; metal-binding site
111780000927	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
111780000928	putative DNA binding site [nucleotide binding]; other site
111780000929	putative metal binding site [ion binding]; other site
111780000930	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
111780000931	active site
111780000932	catalytic site [active]
111780000933	substrate binding site [chemical binding]; other site
111780000934	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
111780000935	active site
111780000936	DNA binding site [nucleotide binding]
111780000937	catalytic site [active]
111780000938	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
111780000939	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
111780000940	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
111780000941	putative active site [active]
111780000942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
111780000943	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
111780000944	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
111780000945	active site
111780000946	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
111780000947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780000948	Walker A motif; other site
111780000949	ATP binding site [chemical binding]; other site
111780000950	Walker B motif; other site
111780000951	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
111780000952	RxxxH motif; other site
111780000953	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
111780000954	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
111780000955	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
111780000956	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
111780000957	proposed catalytic triad [active]
111780000958	active site nucleophile [active]
111780000959	cytochrome c biogenesis protein; Region: ccsA; CHL00045
111780000960	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
111780000961	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
111780000962	Ligand Binding Site [chemical binding]; other site
111780000963	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
111780000964	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780000965	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780000966	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
111780000967	Walker A/P-loop; other site
111780000968	ATP binding site [chemical binding]; other site
111780000969	Q-loop/lid; other site
111780000970	ABC transporter signature motif; other site
111780000971	Walker B; other site
111780000972	D-loop; other site
111780000973	H-loop/switch region; other site
111780000974	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
111780000975	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
111780000976	Cupin domain; Region: Cupin_2; cl17218
111780000977	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
111780000978	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000979	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780000980	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000981	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000982	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780000983	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780000984	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
111780000985	DNA-binding interface [nucleotide binding]; DNA binding site
111780000986	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
111780000987	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
111780000988	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
111780000989	catalytic site [active]
111780000990	subunit interface [polypeptide binding]; other site
111780000991	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780000992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780000993	active site
111780000994	phosphorylation site [posttranslational modification]
111780000995	intermolecular recognition site; other site
111780000996	dimerization interface [polypeptide binding]; other site
111780000997	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780000998	DNA binding site [nucleotide binding]
111780000999	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
111780001000	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
111780001001	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
111780001002	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
111780001003	multimerization interface [polypeptide binding]; other site
111780001004	RbcX protein; Region: RcbX; pfam02341
111780001005	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
111780001006	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
111780001007	homodimer interface [polypeptide binding]; other site
111780001008	active site
111780001009	heterodimer interface [polypeptide binding]; other site
111780001010	catalytic residue [active]
111780001011	metal binding site [ion binding]; metal-binding site
111780001012	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
111780001013	putative trimer interface [polypeptide binding]; other site
111780001014	putative CoA binding site [chemical binding]; other site
111780001015	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
111780001016	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
111780001017	trimer interface [polypeptide binding]; other site
111780001018	active site
111780001019	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
111780001020	putative multimerization interface [polypeptide binding]; other site
111780001021	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
111780001022	putative multimerization interface [polypeptide binding]; other site
111780001023	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
111780001024	putative multimerization interface [polypeptide binding]; other site
111780001025	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
111780001026	putative multimerization interface [polypeptide binding]; other site
111780001027	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
111780001028	Hexamer/Pentamer interface [polypeptide binding]; other site
111780001029	central pore; other site
111780001030	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780001031	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780001032	Hexamer interface [polypeptide binding]; other site
111780001033	Hexagonal pore residue; other site
111780001034	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780001035	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780001036	Hexamer interface [polypeptide binding]; other site
111780001037	Hexagonal pore residue; other site
111780001038	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780001039	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780001040	Hexamer interface [polypeptide binding]; other site
111780001041	Hexagonal pore residue; other site
111780001042	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
111780001043	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
111780001044	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780001045	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
111780001046	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780001047	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
111780001048	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
111780001049	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780001050	ATP binding site [chemical binding]; other site
111780001051	putative Mg++ binding site [ion binding]; other site
111780001052	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
111780001053	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
111780001054	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780001055	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780001056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780001057	DNA binding residues [nucleotide binding]
111780001058	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
111780001059	feedback inhibition sensing region; other site
111780001060	homohexameric interface [polypeptide binding]; other site
111780001061	nucleotide binding site [chemical binding]; other site
111780001062	N-acetyl-L-glutamate binding site [chemical binding]; other site
111780001063	shikimate kinase; Reviewed; Region: aroK; PRK00131
111780001064	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
111780001065	ADP binding site [chemical binding]; other site
111780001066	magnesium binding site [ion binding]; other site
111780001067	putative shikimate binding site; other site
111780001068	AAA ATPase domain; Region: AAA_16; pfam13191
111780001069	aromatic acid decarboxylase; Validated; Region: PRK05920
111780001070	Flavoprotein; Region: Flavoprotein; pfam02441
111780001071	HEAT repeats; Region: HEAT_2; pfam13646
111780001072	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
111780001073	HEAT repeats; Region: HEAT_2; pfam13646
111780001074	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
111780001075	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780001076	Coenzyme A binding pocket [chemical binding]; other site
111780001077	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780001078	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780001079	active site
111780001080	ATP binding site [chemical binding]; other site
111780001081	substrate binding site [chemical binding]; other site
111780001082	activation loop (A-loop); other site
111780001083	Protein kinase domain; Region: Pkinase; pfam00069
111780001084	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780001085	active site
111780001086	ATP binding site [chemical binding]; other site
111780001087	substrate binding site [chemical binding]; other site
111780001088	activation loop (A-loop); other site
111780001089	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780001090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001091	binding surface
111780001092	TPR motif; other site
111780001093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001094	binding surface
111780001095	TPR motif; other site
111780001096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001097	binding surface
111780001098	TPR motif; other site
111780001099	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
111780001100	Clp amino terminal domain; Region: Clp_N; pfam02861
111780001101	Clp amino terminal domain; Region: Clp_N; pfam02861
111780001102	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780001103	Walker A motif; other site
111780001104	ATP binding site [chemical binding]; other site
111780001105	Walker B motif; other site
111780001106	arginine finger; other site
111780001107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780001108	Walker A motif; other site
111780001109	ATP binding site [chemical binding]; other site
111780001110	Walker B motif; other site
111780001111	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
111780001112	Sporulation related domain; Region: SPOR; cl10051
111780001113	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
111780001114	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
111780001115	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
111780001116	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780001117	Response regulator receiver domain; Region: Response_reg; pfam00072
111780001118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001119	active site
111780001120	phosphorylation site [posttranslational modification]
111780001121	intermolecular recognition site; other site
111780001122	dimerization interface [polypeptide binding]; other site
111780001123	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780001124	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780001125	PAS domain S-box; Region: sensory_box; TIGR00229
111780001126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001127	putative active site [active]
111780001128	heme pocket [chemical binding]; other site
111780001129	PAS fold; Region: PAS_4; pfam08448
111780001130	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
111780001131	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001132	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001133	putative active site [active]
111780001134	heme pocket [chemical binding]; other site
111780001135	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001136	putative active site [active]
111780001137	heme pocket [chemical binding]; other site
111780001138	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780001139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001140	dimer interface [polypeptide binding]; other site
111780001141	phosphorylation site [posttranslational modification]
111780001142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001143	ATP binding site [chemical binding]; other site
111780001144	Mg2+ binding site [ion binding]; other site
111780001145	G-X-G motif; other site
111780001146	Response regulator receiver domain; Region: Response_reg; pfam00072
111780001147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001148	active site
111780001149	phosphorylation site [posttranslational modification]
111780001150	intermolecular recognition site; other site
111780001151	dimerization interface [polypeptide binding]; other site
111780001152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780001153	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001154	dimer interface [polypeptide binding]; other site
111780001155	phosphorylation site [posttranslational modification]
111780001156	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
111780001157	KaiA domain; Region: KaiA; pfam07688
111780001158	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
111780001159	tetramer interface [polypeptide binding]; other site
111780001160	dimer interface [polypeptide binding]; other site
111780001161	circadian clock protein KaiC; Reviewed; Region: PRK09302
111780001162	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
111780001163	Walker A motif; other site
111780001164	ATP binding site [chemical binding]; other site
111780001165	Walker B motif; other site
111780001166	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780001167	ATP binding site [chemical binding]; other site
111780001168	Walker B motif; other site
111780001169	RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127
111780001170	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
111780001171	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
111780001172	ligand binding site [chemical binding]; other site
111780001173	homodimer interface [polypeptide binding]; other site
111780001174	NAD(P) binding site [chemical binding]; other site
111780001175	trimer interface B [polypeptide binding]; other site
111780001176	trimer interface A [polypeptide binding]; other site
111780001177	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
111780001178	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
111780001179	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
111780001180	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
111780001181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780001182	FeS/SAM binding site; other site
111780001183	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
111780001184	Pyruvate formate lyase 1; Region: PFL1; cd01678
111780001185	coenzyme A binding site [chemical binding]; other site
111780001186	active site
111780001187	catalytic residues [active]
111780001188	glycine loop; other site
111780001189	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
111780001190	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
111780001191	motif 1; other site
111780001192	active site
111780001193	motif 2; other site
111780001194	motif 3; other site
111780001195	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
111780001196	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
111780001197	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780001198	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
111780001199	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780001200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780001201	dimer interface [polypeptide binding]; other site
111780001202	conserved gate region; other site
111780001203	putative PBP binding loops; other site
111780001204	ABC-ATPase subunit interface; other site
111780001205	Pirin-related protein [General function prediction only]; Region: COG1741
111780001206	Pirin; Region: Pirin; pfam02678
111780001207	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
111780001208	dimer interface [polypeptide binding]; other site
111780001209	FMN binding site [chemical binding]; other site
111780001210	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
111780001211	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780001212	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
111780001213	dimerization interface [polypeptide binding]; other site
111780001214	substrate binding pocket [chemical binding]; other site
111780001215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780001216	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
111780001217	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
111780001218	domain interfaces; other site
111780001219	active site
111780001220	YceG-like family; Region: YceG; pfam02618
111780001221	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
111780001222	dimerization interface [polypeptide binding]; other site
111780001223	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
111780001224	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
111780001225	Clp protease ATP binding subunit; Region: clpC; CHL00095
111780001226	Clp amino terminal domain; Region: Clp_N; pfam02861
111780001227	Clp amino terminal domain; Region: Clp_N; pfam02861
111780001228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780001229	Walker A motif; other site
111780001230	ATP binding site [chemical binding]; other site
111780001231	Walker B motif; other site
111780001232	arginine finger; other site
111780001233	UvrB/uvrC motif; Region: UVR; pfam02151
111780001234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780001235	Walker A motif; other site
111780001236	ATP binding site [chemical binding]; other site
111780001237	Walker B motif; other site
111780001238	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
111780001239	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
111780001240	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
111780001241	diaminopimelate decarboxylase; Region: lysA; TIGR01048
111780001242	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
111780001243	active site
111780001244	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
111780001245	substrate binding site [chemical binding]; other site
111780001246	catalytic residues [active]
111780001247	dimer interface [polypeptide binding]; other site
111780001248	TIGR00159 family protein; Region: TIGR00159
111780001249	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
111780001250	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
111780001251	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780001252	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
111780001253	HSP70 interaction site [polypeptide binding]; other site
111780001254	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
111780001255	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
111780001256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780001257	Coenzyme A binding pocket [chemical binding]; other site
111780001258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
111780001259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
111780001260	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
111780001261	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780001262	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780001263	ligand binding site [chemical binding]; other site
111780001264	flexible hinge region; other site
111780001265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780001266	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
111780001267	dimer interface [polypeptide binding]; other site
111780001268	motif 1; other site
111780001269	active site
111780001270	motif 2; other site
111780001271	motif 3; other site
111780001272	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780001273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001274	active site
111780001275	phosphorylation site [posttranslational modification]
111780001276	intermolecular recognition site; other site
111780001277	dimerization interface [polypeptide binding]; other site
111780001278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780001279	DNA binding site [nucleotide binding]
111780001280	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780001281	PAS domain; Region: PAS; smart00091
111780001282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001283	dimer interface [polypeptide binding]; other site
111780001284	phosphorylation site [posttranslational modification]
111780001285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001286	ATP binding site [chemical binding]; other site
111780001287	Mg2+ binding site [ion binding]; other site
111780001288	G-X-G motif; other site
111780001289	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
111780001290	PhoU domain; Region: PhoU; pfam01895
111780001291	PhoU domain; Region: PhoU; pfam01895
111780001292	S-layer homology domain; Region: SLH; pfam00395
111780001293	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780001294	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
111780001295	Uncharacterized conserved protein [Function unknown]; Region: COG1432
111780001296	LabA_like proteins; Region: LabA; cd10911
111780001297	putative metal binding site [ion binding]; other site
111780001298	2-isopropylmalate synthase; Validated; Region: PRK00915
111780001299	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
111780001300	active site
111780001301	catalytic residues [active]
111780001302	metal binding site [ion binding]; metal-binding site
111780001303	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
111780001304	excinuclease ABC subunit B; Provisional; Region: PRK05298
111780001305	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780001306	ATP binding site [chemical binding]; other site
111780001307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780001308	nucleotide binding region [chemical binding]; other site
111780001309	ATP-binding site [chemical binding]; other site
111780001310	Ultra-violet resistance protein B; Region: UvrB; pfam12344
111780001311	UvrB/uvrC motif; Region: UVR; pfam02151
111780001312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
111780001313	DinB superfamily; Region: DinB_2; pfam12867
111780001314	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
111780001315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
111780001316	motif II; other site
111780001317	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
111780001318	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
111780001319	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
111780001320	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
111780001321	transmembrane helices; other site
111780001322	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
111780001323	putative transporter; Provisional; Region: PRK10484
111780001324	Na binding site [ion binding]; other site
111780001325	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
111780001326	hypothetical protein; Provisional; Region: PRK04194
111780001327	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
111780001328	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
111780001329	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
111780001330	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
111780001331	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780001332	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
111780001333	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
111780001334	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
111780001335	E3 interaction surface; other site
111780001336	lipoyl attachment site [posttranslational modification]; other site
111780001337	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
111780001338	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
111780001339	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
111780001340	tetramer interface [polypeptide binding]; other site
111780001341	TPP-binding site [chemical binding]; other site
111780001342	heterodimer interface [polypeptide binding]; other site
111780001343	phosphorylation loop region [posttranslational modification]
111780001344	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
111780001345	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
111780001346	PYR/PP interface [polypeptide binding]; other site
111780001347	dimer interface [polypeptide binding]; other site
111780001348	TPP binding site [chemical binding]; other site
111780001349	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
111780001350	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
111780001351	trimer interface [polypeptide binding]; other site
111780001352	active site
111780001353	substrate binding site [chemical binding]; other site
111780001354	CoA binding site [chemical binding]; other site
111780001355	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780001356	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780001357	metal binding site [ion binding]; metal-binding site
111780001358	active site
111780001359	I-site; other site
111780001360	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780001361	Ligand Binding Site [chemical binding]; other site
111780001362	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780001363	Ligand Binding Site [chemical binding]; other site
111780001364	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
111780001365	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
111780001366	Sulfate transporter family; Region: Sulfate_transp; pfam00916
111780001367	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
111780001368	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
111780001369	Subunit I/III interface [polypeptide binding]; other site
111780001370	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
111780001371	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
111780001372	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
111780001373	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
111780001374	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
111780001375	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
111780001376	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
111780001377	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
111780001378	UbiA prenyltransferase family; Region: UbiA; pfam01040
111780001379	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
111780001380	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
111780001381	Walker A/P-loop; other site
111780001382	ATP binding site [chemical binding]; other site
111780001383	Q-loop/lid; other site
111780001384	ABC transporter signature motif; other site
111780001385	Walker B; other site
111780001386	D-loop; other site
111780001387	H-loop/switch region; other site
111780001388	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
111780001389	mce related protein; Region: MCE; pfam02470
111780001390	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
111780001391	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780001392	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780001393	active site
111780001394	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
111780001395	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
111780001396	putative dimer interface [polypeptide binding]; other site
111780001397	putative anticodon binding site; other site
111780001398	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
111780001399	homodimer interface [polypeptide binding]; other site
111780001400	motif 1; other site
111780001401	motif 2; other site
111780001402	active site
111780001403	motif 3; other site
111780001404	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
111780001405	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780001406	Ligand Binding Site [chemical binding]; other site
111780001407	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
111780001408	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
111780001409	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
111780001410	peptide binding site [polypeptide binding]; other site
111780001411	dimer interface [polypeptide binding]; other site
111780001412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780001413	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780001414	putative substrate translocation pore; other site
111780001415	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780001416	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
111780001417	ligand binding site [chemical binding]; other site
111780001418	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
111780001419	putative switch regulator; other site
111780001420	non-specific DNA interactions [nucleotide binding]; other site
111780001421	DNA binding site [nucleotide binding]
111780001422	sequence specific DNA binding site [nucleotide binding]; other site
111780001423	putative cAMP binding site [chemical binding]; other site
111780001424	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780001425	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
111780001426	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
111780001427	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
111780001428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780001429	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780001430	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780001431	active site
111780001432	ATP binding site [chemical binding]; other site
111780001433	substrate binding site [chemical binding]; other site
111780001434	activation loop (A-loop); other site
111780001435	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
111780001436	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
111780001437	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
111780001438	putative dimer interface [polypeptide binding]; other site
111780001439	N-terminal domain interface [polypeptide binding]; other site
111780001440	putative substrate binding pocket (H-site) [chemical binding]; other site
111780001441	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
111780001442	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
111780001443	active site
111780001444	Predicted transcriptional regulators [Transcription]; Region: COG1733
111780001445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
111780001446	dimerization interface [polypeptide binding]; other site
111780001447	putative Zn2+ binding site [ion binding]; other site
111780001448	putative DNA binding site [nucleotide binding]; other site
111780001449	SCP-2 sterol transfer family; Region: SCP2; cl01225
111780001450	PQQ-like domain; Region: PQQ_2; pfam13360
111780001451	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
111780001452	nudix motif; other site
111780001453	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
111780001454	homotrimer interaction site [polypeptide binding]; other site
111780001455	putative active site [active]
111780001456	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
111780001457	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
111780001458	Cytochrome P450; Region: p450; cl12078
111780001459	WYL domain; Region: WYL; pfam13280
111780001460	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
111780001461	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
111780001462	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
111780001463	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
111780001464	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
111780001465	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
111780001466	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
111780001467	DDE superfamily endonuclease; Region: DDE_5; cl17874
111780001468	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
111780001469	active site clefts [active]
111780001470	zinc binding site [ion binding]; other site
111780001471	dimer interface [polypeptide binding]; other site
111780001472	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
111780001473	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
111780001474	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
111780001475	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
111780001476	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
111780001477	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
111780001478	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
111780001479	Walker A/P-loop; other site
111780001480	ATP binding site [chemical binding]; other site
111780001481	Q-loop/lid; other site
111780001482	ABC transporter signature motif; other site
111780001483	Walker B; other site
111780001484	D-loop; other site
111780001485	H-loop/switch region; other site
111780001486	PetN; Region: PetN; pfam03742
111780001487	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
111780001488	Phycobilisome protein; Region: Phycobilisome; cl08227
111780001489	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780001490	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780001491	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780001492	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780001493	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780001494	RNA methyltransferase, RsmE family; Region: TIGR00046
111780001495	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
111780001496	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
111780001497	S-layer homology domain; Region: SLH; pfam00395
111780001498	S-layer homology domain; Region: SLH; pfam00395
111780001499	Predicted transcriptional regulators [Transcription]; Region: COG1725
111780001500	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
111780001501	DNA-binding site [nucleotide binding]; DNA binding site
111780001502	EVE domain; Region: EVE; pfam01878
111780001503	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
111780001504	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
111780001505	metal ion-dependent adhesion site (MIDAS); other site
111780001506	CBD_II domain; Region: CBD_II; smart00637
111780001507	endoglucanase; Region: PLN02308
111780001508	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
111780001509	FOG: CBS domain [General function prediction only]; Region: COG0517
111780001510	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
111780001511	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780001512	GAF domain; Region: GAF; pfam01590
111780001513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
111780001514	putative active site [active]
111780001515	heme pocket [chemical binding]; other site
111780001516	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780001517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
111780001518	putative active site [active]
111780001519	heme pocket [chemical binding]; other site
111780001520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001521	dimer interface [polypeptide binding]; other site
111780001522	phosphorylation site [posttranslational modification]
111780001523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001524	ATP binding site [chemical binding]; other site
111780001525	Mg2+ binding site [ion binding]; other site
111780001526	G-X-G motif; other site
111780001527	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
111780001528	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
111780001529	NAD(P) binding site [chemical binding]; other site
111780001530	catalytic residues [active]
111780001531	GAF domain; Region: GAF_3; pfam13492
111780001532	GAF domain; Region: GAF_2; pfam13185
111780001533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780001534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001535	dimer interface [polypeptide binding]; other site
111780001536	phosphorylation site [posttranslational modification]
111780001537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001538	ATP binding site [chemical binding]; other site
111780001539	Mg2+ binding site [ion binding]; other site
111780001540	G-X-G motif; other site
111780001541	Response regulator receiver domain; Region: Response_reg; pfam00072
111780001542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001543	active site
111780001544	phosphorylation site [posttranslational modification]
111780001545	intermolecular recognition site; other site
111780001546	dimerization interface [polypeptide binding]; other site
111780001547	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001548	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001549	putative active site [active]
111780001550	heme pocket [chemical binding]; other site
111780001551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001552	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001553	putative active site [active]
111780001554	heme pocket [chemical binding]; other site
111780001555	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001557	putative active site [active]
111780001558	heme pocket [chemical binding]; other site
111780001559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001560	putative active site [active]
111780001561	heme pocket [chemical binding]; other site
111780001562	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001563	PAS fold; Region: PAS_3; pfam08447
111780001564	putative active site [active]
111780001565	heme pocket [chemical binding]; other site
111780001566	PAS fold; Region: PAS_4; pfam08448
111780001567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780001568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001569	dimer interface [polypeptide binding]; other site
111780001570	phosphorylation site [posttranslational modification]
111780001571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001572	ATP binding site [chemical binding]; other site
111780001573	Mg2+ binding site [ion binding]; other site
111780001574	G-X-G motif; other site
111780001575	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780001576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001577	active site
111780001578	phosphorylation site [posttranslational modification]
111780001579	intermolecular recognition site; other site
111780001580	dimerization interface [polypeptide binding]; other site
111780001581	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
111780001582	oligomeric interface; other site
111780001583	putative active site [active]
111780001584	homodimer interface [polypeptide binding]; other site
111780001585	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
111780001586	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
111780001587	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
111780001588	Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958
111780001589	NodB motif; other site
111780001590	putative active site [active]
111780001591	putative catalytic site [active]
111780001592	Uncharacterized conserved protein [Function unknown]; Region: COG1615
111780001593	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
111780001594	Predicted membrane protein [Function unknown]; Region: COG1971
111780001595	Domain of unknown function DUF; Region: DUF204; pfam02659
111780001596	Domain of unknown function DUF; Region: DUF204; pfam02659
111780001597	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
111780001598	nucleotide binding site/active site [active]
111780001599	HIT family signature motif; other site
111780001600	catalytic residue [active]
111780001601	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
111780001602	catalytic motif [active]
111780001603	Catalytic residue [active]
111780001604	S-layer homology domain; Region: SLH; pfam00395
111780001605	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780001606	multifunctional aminopeptidase A; Provisional; Region: PRK00913
111780001607	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
111780001608	interface (dimer of trimers) [polypeptide binding]; other site
111780001609	Substrate-binding/catalytic site; other site
111780001610	Zn-binding sites [ion binding]; other site
111780001611	rod shape-determining protein MreB; Provisional; Region: PRK13927
111780001612	MreB and similar proteins; Region: MreB_like; cd10225
111780001613	nucleotide binding site [chemical binding]; other site
111780001614	Mg binding site [ion binding]; other site
111780001615	putative protofilament interaction site [polypeptide binding]; other site
111780001616	RodZ interaction site [polypeptide binding]; other site
111780001617	rod shape-determining protein MreC; Provisional; Region: PRK13922
111780001618	rod shape-determining protein MreC; Region: MreC; pfam04085
111780001619	rod shape-determining protein MreD; Region: MreD; cl01087
111780001620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780001621	carotene isomerase; Region: carot_isom; TIGR02730
111780001622	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780001623	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
111780001624	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780001625	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
111780001626	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
111780001627	active site
111780001628	FOG: CBS domain [General function prediction only]; Region: COG0517
111780001629	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
111780001630	FOG: CBS domain [General function prediction only]; Region: COG0517
111780001631	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
111780001632	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780001633	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780001634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001635	PAS fold; Region: PAS_3; pfam08447
111780001636	putative active site [active]
111780001637	heme pocket [chemical binding]; other site
111780001638	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001640	putative active site [active]
111780001641	heme pocket [chemical binding]; other site
111780001642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001643	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001644	putative active site [active]
111780001645	heme pocket [chemical binding]; other site
111780001646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001647	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001648	putative active site [active]
111780001649	heme pocket [chemical binding]; other site
111780001650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001651	putative active site [active]
111780001652	heme pocket [chemical binding]; other site
111780001653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001654	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001655	putative active site [active]
111780001656	heme pocket [chemical binding]; other site
111780001657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001658	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780001659	putative active site [active]
111780001660	heme pocket [chemical binding]; other site
111780001661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780001662	putative active site [active]
111780001663	heme pocket [chemical binding]; other site
111780001664	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780001665	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780001666	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780001667	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001668	dimer interface [polypeptide binding]; other site
111780001669	phosphorylation site [posttranslational modification]
111780001670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001671	ATP binding site [chemical binding]; other site
111780001672	Mg2+ binding site [ion binding]; other site
111780001673	G-X-G motif; other site
111780001674	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780001675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001676	active site
111780001677	phosphorylation site [posttranslational modification]
111780001678	intermolecular recognition site; other site
111780001679	dimerization interface [polypeptide binding]; other site
111780001680	Response regulator receiver domain; Region: Response_reg; pfam00072
111780001681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001682	active site
111780001683	phosphorylation site [posttranslational modification]
111780001684	intermolecular recognition site; other site
111780001685	dimerization interface [polypeptide binding]; other site
111780001686	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780001687	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780001688	metal binding site [ion binding]; metal-binding site
111780001689	active site
111780001690	I-site; other site
111780001691	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780001692	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
111780001693	dimer interface [polypeptide binding]; other site
111780001694	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
111780001695	Histidine kinase; Region: HisKA_3; pfam07730
111780001696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001697	ATP binding site [chemical binding]; other site
111780001698	Mg2+ binding site [ion binding]; other site
111780001699	G-X-G motif; other site
111780001700	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780001701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001702	active site
111780001703	phosphorylation site [posttranslational modification]
111780001704	intermolecular recognition site; other site
111780001705	dimerization interface [polypeptide binding]; other site
111780001706	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780001707	DNA binding residues [nucleotide binding]
111780001708	dimerization interface [polypeptide binding]; other site
111780001709	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780001710	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780001711	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
111780001712	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
111780001713	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780001714	YcfA-like protein; Region: YcfA; cl00752
111780001715	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
111780001716	FAD binding domain; Region: FAD_binding_4; pfam01565
111780001717	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
111780001718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780001719	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780001720	Probable transposase; Region: OrfB_IS605; pfam01385
111780001721	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780001722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
111780001723	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
111780001724	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
111780001725	MoaE interaction surface [polypeptide binding]; other site
111780001726	MoeB interaction surface [polypeptide binding]; other site
111780001727	thiocarboxylated glycine; other site
111780001728	GTPase Era; Reviewed; Region: era; PRK00089
111780001729	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
111780001730	G1 box; other site
111780001731	GTP/Mg2+ binding site [chemical binding]; other site
111780001732	Switch I region; other site
111780001733	G2 box; other site
111780001734	Switch II region; other site
111780001735	G3 box; other site
111780001736	G4 box; other site
111780001737	G5 box; other site
111780001738	KH domain; Region: KH_2; pfam07650
111780001739	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
111780001740	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
111780001741	active site
111780001742	Zn binding site [ion binding]; other site
111780001743	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
111780001744	Peptidase family M50; Region: Peptidase_M50; pfam02163
111780001745	active site
111780001746	putative substrate binding region [chemical binding]; other site
111780001747	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780001748	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780001749	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780001750	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780001751	active site
111780001752	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
111780001753	putative metal binding site [ion binding]; other site
111780001754	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
111780001755	putative metal binding site [ion binding]; other site
111780001756	Right handed beta helix region; Region: Beta_helix; pfam13229
111780001757	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
111780001758	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
111780001759	NAD binding site [chemical binding]; other site
111780001760	homodimer interface [polypeptide binding]; other site
111780001761	active site
111780001762	substrate binding site [chemical binding]; other site
111780001763	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780001764	putative active site [active]
111780001765	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780001766	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780001767	ligand binding site [chemical binding]; other site
111780001768	flexible hinge region; other site
111780001769	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
111780001770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780001771	Walker A motif; other site
111780001772	ATP binding site [chemical binding]; other site
111780001773	Walker B motif; other site
111780001774	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
111780001775	4Fe-4S binding domain; Region: Fer4_5; pfam12801
111780001776	4Fe-4S binding domain; Region: Fer4_5; pfam12801
111780001777	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
111780001778	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
111780001779	Walker A/P-loop; other site
111780001780	ATP binding site [chemical binding]; other site
111780001781	Q-loop/lid; other site
111780001782	ABC transporter signature motif; other site
111780001783	Walker B; other site
111780001784	D-loop; other site
111780001785	H-loop/switch region; other site
111780001786	6-phosphofructokinase; Provisional; Region: PRK14071
111780001787	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
111780001788	active site
111780001789	ADP/pyrophosphate binding site [chemical binding]; other site
111780001790	dimerization interface [polypeptide binding]; other site
111780001791	allosteric effector site; other site
111780001792	fructose-1,6-bisphosphate binding site; other site
111780001793	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780001794	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
111780001795	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
111780001796	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
111780001797	trimer interface [polypeptide binding]; other site
111780001798	active site
111780001799	substrate binding site [chemical binding]; other site
111780001800	CoA binding site [chemical binding]; other site
111780001801	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
111780001802	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
111780001803	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
111780001804	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
111780001805	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
111780001806	pantothenate kinase; Reviewed; Region: PRK13331
111780001807	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
111780001808	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
111780001809	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
111780001810	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
111780001811	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780001812	SnoaL-like domain; Region: SnoaL_2; pfam12680
111780001813	hydrolase, alpha/beta fold family protein; Region: PLN02824
111780001814	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
111780001815	FeoA domain; Region: FeoA; pfam04023
111780001816	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
111780001817	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
111780001818	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780001819	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
111780001820	methionine sulfoxide reductase B; Provisional; Region: PRK00222
111780001821	SelR domain; Region: SelR; pfam01641
111780001822	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
111780001823	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
111780001824	RNA binding surface [nucleotide binding]; other site
111780001825	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
111780001826	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780001827	catalytic triad [active]
111780001828	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
111780001829	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
111780001830	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
111780001831	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
111780001832	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
111780001833	active site
111780001834	interdomain interaction site; other site
111780001835	putative metal-binding site [ion binding]; other site
111780001836	nucleotide binding site [chemical binding]; other site
111780001837	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
111780001838	domain I; other site
111780001839	phosphate binding site [ion binding]; other site
111780001840	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
111780001841	domain II; other site
111780001842	domain III; other site
111780001843	nucleotide binding site [chemical binding]; other site
111780001844	DNA binding groove [nucleotide binding]
111780001845	catalytic site [active]
111780001846	domain IV; other site
111780001847	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
111780001848	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
111780001849	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
111780001850	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
111780001851	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780001852	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001853	binding surface
111780001854	TPR motif; other site
111780001855	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780001856	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780001857	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780001858	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780001859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
111780001860	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
111780001861	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780001862	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
111780001863	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
111780001864	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
111780001865	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
111780001866	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
111780001867	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
111780001868	metal binding site [ion binding]; metal-binding site
111780001869	dimer interface [polypeptide binding]; other site
111780001870	Response regulator receiver domain; Region: Response_reg; pfam00072
111780001871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001872	active site
111780001873	phosphorylation site [posttranslational modification]
111780001874	intermolecular recognition site; other site
111780001875	dimerization interface [polypeptide binding]; other site
111780001876	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780001877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001878	dimer interface [polypeptide binding]; other site
111780001879	phosphorylation site [posttranslational modification]
111780001880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001881	ATP binding site [chemical binding]; other site
111780001882	Mg2+ binding site [ion binding]; other site
111780001883	G-X-G motif; other site
111780001884	Response regulator receiver domain; Region: Response_reg; pfam00072
111780001885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001886	active site
111780001887	phosphorylation site [posttranslational modification]
111780001888	intermolecular recognition site; other site
111780001889	dimerization interface [polypeptide binding]; other site
111780001890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780001891	dimer interface [polypeptide binding]; other site
111780001892	phosphorylation site [posttranslational modification]
111780001893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780001894	ATP binding site [chemical binding]; other site
111780001895	Mg2+ binding site [ion binding]; other site
111780001896	G-X-G motif; other site
111780001897	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
111780001898	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
111780001899	Walker A/P-loop; other site
111780001900	ATP binding site [chemical binding]; other site
111780001901	Q-loop/lid; other site
111780001902	ABC transporter signature motif; other site
111780001903	Walker B; other site
111780001904	D-loop; other site
111780001905	H-loop/switch region; other site
111780001906	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
111780001907	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780001908	Ligand Binding Site [chemical binding]; other site
111780001909	S-layer homology domain; Region: SLH; pfam00395
111780001910	S-layer homology domain; Region: SLH; pfam00395
111780001911	S-layer homology domain; Region: SLH; pfam00395
111780001912	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
111780001913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780001914	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780001915	Probable transposase; Region: OrfB_IS605; pfam01385
111780001916	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780001917	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
111780001918	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
111780001919	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
111780001920	generic binding surface I; other site
111780001921	generic binding surface II; other site
111780001922	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780001923	phosphopeptide binding site; other site
111780001924	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780001925	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780001926	active site
111780001927	catalytic tetrad [active]
111780001928	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
111780001929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780001930	Walker A motif; other site
111780001931	ATP binding site [chemical binding]; other site
111780001932	Walker B motif; other site
111780001933	arginine finger; other site
111780001934	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
111780001935	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001936	binding surface
111780001937	TPR motif; other site
111780001938	TPR repeat; Region: TPR_11; pfam13414
111780001939	TPR repeat; Region: TPR_11; pfam13414
111780001940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001941	binding surface
111780001942	TPR motif; other site
111780001943	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
111780001944	cytidine deaminase; Region: PLN02402
111780001945	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
111780001946	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
111780001947	C-terminal domain interface [polypeptide binding]; other site
111780001948	active site
111780001949	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
111780001950	active site
111780001951	N-terminal domain interface [polypeptide binding]; other site
111780001952	DNA gyrase subunit A; Validated; Region: PRK05560
111780001953	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
111780001954	CAP-like domain; other site
111780001955	active site
111780001956	primary dimer interface [polypeptide binding]; other site
111780001957	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780001958	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780001959	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780001960	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780001961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780001962	active site
111780001963	phosphorylation site [posttranslational modification]
111780001964	intermolecular recognition site; other site
111780001965	dimerization interface [polypeptide binding]; other site
111780001966	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780001967	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001968	TPR motif; other site
111780001969	binding surface
111780001970	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
111780001971	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001972	binding surface
111780001973	TPR motif; other site
111780001974	TPR repeat; Region: TPR_11; pfam13414
111780001975	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001976	binding surface
111780001977	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780001978	TPR motif; other site
111780001979	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
111780001980	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780001981	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780001982	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
111780001983	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
111780001984	FtsX-like permease family; Region: FtsX; pfam02687
111780001985	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
111780001986	catalytic core [active]
111780001987	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
111780001988	catalytic core [active]
111780001989	CAAX protease self-immunity; Region: Abi; pfam02517
111780001990	phosphoglucomutase; Region: PLN02307
111780001991	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
111780001992	substrate binding site [chemical binding]; other site
111780001993	dimer interface [polypeptide binding]; other site
111780001994	active site
111780001995	metal binding site [ion binding]; metal-binding site
111780001996	TPR repeat; Region: TPR_11; pfam13414
111780001997	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780001998	binding surface
111780001999	TPR motif; other site
111780002000	TPR repeat; Region: TPR_11; pfam13414
111780002001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780002002	binding surface
111780002003	TPR motif; other site
111780002004	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780002005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780002006	TPR motif; other site
111780002007	binding surface
111780002008	TPR repeat; Region: TPR_11; pfam13414
111780002009	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
111780002010	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
111780002011	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
111780002012	enolase; Provisional; Region: eno; PRK00077
111780002013	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
111780002014	dimer interface [polypeptide binding]; other site
111780002015	metal binding site [ion binding]; metal-binding site
111780002016	substrate binding pocket [chemical binding]; other site
111780002017	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
111780002018	homodimer interface [polypeptide binding]; other site
111780002019	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
111780002020	active site pocket [active]
111780002021	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
111780002022	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
111780002023	NAD binding site [chemical binding]; other site
111780002024	homodimer interface [polypeptide binding]; other site
111780002025	active site
111780002026	substrate binding site [chemical binding]; other site
111780002027	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
111780002028	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
111780002029	substrate binding pocket [chemical binding]; other site
111780002030	chain length determination region; other site
111780002031	substrate-Mg2+ binding site; other site
111780002032	catalytic residues [active]
111780002033	aspartate-rich region 1; other site
111780002034	active site lid residues [active]
111780002035	aspartate-rich region 2; other site
111780002036	glutamate racemase; Provisional; Region: PRK00865
111780002037	AMIN domain; Region: AMIN; pfam11741
111780002038	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
111780002039	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
111780002040	active site
111780002041	metal binding site [ion binding]; metal-binding site
111780002042	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780002043	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
111780002044	cyanate hydratase; Validated; Region: PRK02866
111780002045	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
111780002046	oligomer interface [polypeptide binding]; other site
111780002047	active site
111780002048	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
111780002049	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
111780002050	UGMP family protein; Validated; Region: PRK09604
111780002051	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
111780002052	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
111780002053	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
111780002054	oligomer interface [polypeptide binding]; other site
111780002055	metal binding site [ion binding]; metal-binding site
111780002056	metal binding site [ion binding]; metal-binding site
111780002057	Cl binding site [ion binding]; other site
111780002058	aspartate ring; other site
111780002059	basic sphincter; other site
111780002060	putative hydrophobic gate; other site
111780002061	periplasmic entrance; other site
111780002062	Predicted integral membrane protein [Function unknown]; Region: COG0392
111780002063	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780002064	Domain of unknown function DUF20; Region: UPF0118; pfam01594
111780002065	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
111780002066	MgtC family; Region: MgtC; pfam02308
111780002067	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780002068	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780002069	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780002070	ligand binding site [chemical binding]; other site
111780002071	flexible hinge region; other site
111780002072	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
111780002073	putative switch regulator; other site
111780002074	non-specific DNA interactions [nucleotide binding]; other site
111780002075	DNA binding site [nucleotide binding]
111780002076	sequence specific DNA binding site [nucleotide binding]; other site
111780002077	putative cAMP binding site [chemical binding]; other site
111780002078	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
111780002079	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
111780002080	active site pocket [active]
111780002081	putative dimer interface [polypeptide binding]; other site
111780002082	putative cataytic base [active]
111780002083	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
111780002084	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
111780002085	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
111780002086	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
111780002087	putative ligand binding site [chemical binding]; other site
111780002088	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
111780002089	active site
111780002090	catalytic triad [active]
111780002091	oxyanion hole [active]
111780002092	DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191
111780002093	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
111780002094	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
111780002095	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
111780002096	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
111780002097	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
111780002098	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
111780002099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780002100	binding surface
111780002101	TPR motif; other site
111780002102	acetolactate synthase; Reviewed; Region: PRK08322
111780002103	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
111780002104	PYR/PP interface [polypeptide binding]; other site
111780002105	dimer interface [polypeptide binding]; other site
111780002106	TPP binding site [chemical binding]; other site
111780002107	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
111780002108	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
111780002109	TPP-binding site [chemical binding]; other site
111780002110	dimer interface [polypeptide binding]; other site
111780002111	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780002112	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
111780002113	active site
111780002114	metal binding site [ion binding]; metal-binding site
111780002115	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
111780002116	AAA domain; Region: AAA_18; pfam13238
111780002117	ligand-binding site [chemical binding]; other site
111780002118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780002119	Probable transposase; Region: OrfB_IS605; pfam01385
111780002120	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780002121	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
111780002122	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
111780002123	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
111780002124	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
111780002125	DNA binding residues [nucleotide binding]
111780002126	dimer interface [polypeptide binding]; other site
111780002127	metal binding site [ion binding]; metal-binding site
111780002128	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
111780002129	L-type amino acid transporter; Region: 2A0308; TIGR00911
111780002130	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780002131	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780002132	S-adenosylmethionine binding site [chemical binding]; other site
111780002133	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
111780002134	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
111780002135	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
111780002136	FAD binding pocket [chemical binding]; other site
111780002137	FAD binding motif [chemical binding]; other site
111780002138	phosphate binding motif [ion binding]; other site
111780002139	beta-alpha-beta structure motif; other site
111780002140	NAD binding pocket [chemical binding]; other site
111780002141	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
111780002142	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780002143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002144	active site
111780002145	phosphorylation site [posttranslational modification]
111780002146	intermolecular recognition site; other site
111780002147	dimerization interface [polypeptide binding]; other site
111780002148	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780002149	DNA binding site [nucleotide binding]
111780002150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780002151	dimer interface [polypeptide binding]; other site
111780002152	phosphorylation site [posttranslational modification]
111780002153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780002154	ATP binding site [chemical binding]; other site
111780002155	Mg2+ binding site [ion binding]; other site
111780002156	G-X-G motif; other site
111780002157	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
111780002158	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780002159	Domain of unknown function DUF20; Region: UPF0118; pfam01594
111780002160	Yip1 domain; Region: Yip1; pfam04893
111780002161	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
111780002162	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780002163	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
111780002164	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
111780002165	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780002166	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
111780002167	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780002168	motif II; other site
111780002169	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
111780002170	Uncharacterized conserved protein [Function unknown]; Region: COG3461
111780002171	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
111780002172	Mechanosensitive ion channel; Region: MS_channel; pfam00924
111780002173	intracellular protease, PfpI family; Region: PfpI; TIGR01382
111780002174	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
111780002175	conserved cys residue [active]
111780002176	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
111780002177	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
111780002178	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
111780002179	Predicted transcriptional regulator [Transcription]; Region: COG3682
111780002180	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
111780002181	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
111780002182	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
111780002183	putative NAD(P) binding site [chemical binding]; other site
111780002184	Uncharacterized conserved protein [Function unknown]; Region: COG1434
111780002185	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
111780002186	putative active site [active]
111780002187	biotin synthase; Validated; Region: PRK06256
111780002188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780002189	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
111780002190	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
111780002191	Stage II sporulation protein; Region: SpoIID; pfam08486
111780002192	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780002193	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
111780002194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780002195	ATP binding site [chemical binding]; other site
111780002196	Mg2+ binding site [ion binding]; other site
111780002197	G-X-G motif; other site
111780002198	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
111780002199	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780002200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002201	active site
111780002202	phosphorylation site [posttranslational modification]
111780002203	intermolecular recognition site; other site
111780002204	dimerization interface [polypeptide binding]; other site
111780002205	Response regulator receiver domain; Region: Response_reg; pfam00072
111780002206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002207	active site
111780002208	phosphorylation site [posttranslational modification]
111780002209	intermolecular recognition site; other site
111780002210	dimerization interface [polypeptide binding]; other site
111780002211	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
111780002212	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
111780002213	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
111780002214	putative active site [active]
111780002215	putative substrate binding site [chemical binding]; other site
111780002216	putative cosubstrate binding site; other site
111780002217	catalytic site [active]
111780002218	hypothetical protein; Reviewed; Region: PRK12497
111780002219	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
111780002220	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780002221	motif II; other site
111780002222	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780002223	putative binding surface; other site
111780002224	active site
111780002225	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
111780002226	aspartate-rich region 2; other site
111780002227	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
111780002228	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
111780002229	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
111780002230	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
111780002231	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
111780002232	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
111780002233	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
111780002234	trmE is a tRNA modification GTPase; Region: trmE; cd04164
111780002235	G1 box; other site
111780002236	GTP/Mg2+ binding site [chemical binding]; other site
111780002237	Switch I region; other site
111780002238	G2 box; other site
111780002239	Switch II region; other site
111780002240	G3 box; other site
111780002241	G4 box; other site
111780002242	G5 box; other site
111780002243	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
111780002244	DNA repair protein RadA; Provisional; Region: PRK11823
111780002245	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
111780002246	Walker A motif/ATP binding site; other site
111780002247	ATP binding site [chemical binding]; other site
111780002248	Walker B motif; other site
111780002249	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
111780002250	Ycf27; Reviewed; Region: orf27; CHL00148
111780002251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002252	active site
111780002253	phosphorylation site [posttranslational modification]
111780002254	intermolecular recognition site; other site
111780002255	dimerization interface [polypeptide binding]; other site
111780002256	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780002257	DNA binding site [nucleotide binding]
111780002258	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
111780002259	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
111780002260	Integral membrane protein DUF92; Region: DUF92; pfam01940
111780002261	SnoaL-like domain; Region: SnoaL_2; pfam12680
111780002262	phosphodiesterase; Provisional; Region: PRK12704
111780002263	TPR repeat; Region: TPR_11; pfam13414
111780002264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780002265	binding surface
111780002266	TPR motif; other site
111780002267	TPR repeat; Region: TPR_11; pfam13414
111780002268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780002269	binding surface
111780002270	TPR motif; other site
111780002271	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
111780002272	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
111780002273	putative active site [active]
111780002274	Double zinc ribbon; Region: DZR; pfam12773
111780002275	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
111780002276	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
111780002277	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780002278	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780002279	phosphopeptide binding site; other site
111780002280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780002281	binding surface
111780002282	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
111780002283	TPR motif; other site
111780002284	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
111780002285	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
111780002286	N-acetyl-D-glucosamine binding site [chemical binding]; other site
111780002287	catalytic residue [active]
111780002288	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780002289	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780002290	active site
111780002291	ATP binding site [chemical binding]; other site
111780002292	substrate binding site [chemical binding]; other site
111780002293	activation loop (A-loop); other site
111780002294	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780002295	sequence-specific DNA binding site [nucleotide binding]; other site
111780002296	salt bridge; other site
111780002297	AAA domain; Region: AAA_25; pfam13481
111780002298	NACHT domain; Region: NACHT; pfam05729
111780002299	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
111780002300	Calx-beta domain; Region: Calx-beta; cl02522
111780002301	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
111780002302	active site clefts [active]
111780002303	zinc binding site [ion binding]; other site
111780002304	dimer interface [polypeptide binding]; other site
111780002305	proton extrusion protein PcxA; Provisional; Region: PRK02507
111780002306	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
111780002307	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
111780002308	putative active site [active]
111780002309	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
111780002310	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780002311	FeS/SAM binding site; other site
111780002312	HemN C-terminal domain; Region: HemN_C; pfam06969
111780002313	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
111780002314	protein I interface; other site
111780002315	D2 interface; other site
111780002316	protein T interface; other site
111780002317	chlorophyll binding site; other site
111780002318	beta carotene binding site; other site
111780002319	pheophytin binding site; other site
111780002320	manganese-stabilizing polypeptide interface; other site
111780002321	CP43 interface; other site
111780002322	protein L interface; other site
111780002323	oxygen evolving complex binding site; other site
111780002324	bromide binding site; other site
111780002325	quinone binding site; other site
111780002326	Fe binding site [ion binding]; other site
111780002327	core light harvesting interface; other site
111780002328	cytochrome b559 alpha subunit interface; other site
111780002329	cytochrome c-550 interface; other site
111780002330	protein J interface; other site
111780002331	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
111780002332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
111780002333	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780002334	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
111780002335	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
111780002336	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
111780002337	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
111780002338	SnoaL-like domain; Region: SnoaL_3; pfam13474
111780002339	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780002340	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780002341	dimerization interface [polypeptide binding]; other site
111780002342	DNA binding residues [nucleotide binding]
111780002343	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
111780002344	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780002345	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780002346	phosphopeptide binding site; other site
111780002347	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780002348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780002349	metal binding site [ion binding]; metal-binding site
111780002350	active site
111780002351	I-site; other site
111780002352	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780002353	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
111780002354	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780002355	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
111780002356	anti sigma factor interaction site; other site
111780002357	regulatory phosphorylation site [posttranslational modification]; other site
111780002358	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
111780002359	Response regulator receiver domain; Region: Response_reg; pfam00072
111780002360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002361	active site
111780002362	phosphorylation site [posttranslational modification]
111780002363	intermolecular recognition site; other site
111780002364	dimerization interface [polypeptide binding]; other site
111780002365	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
111780002366	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
111780002367	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
111780002368	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
111780002369	Mg2+ binding site [ion binding]; other site
111780002370	G-X-G motif; other site
111780002371	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
111780002372	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
111780002373	active site residue [active]
111780002374	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
111780002375	active site residue [active]
111780002376	Membrane protein of unknown function; Region: DUF360; pfam04020
111780002377	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
111780002378	phosphoribulokinase; Provisional; Region: PRK07429
111780002379	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
111780002380	active site
111780002381	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780002382	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
111780002383	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
111780002384	dimerization interface [polypeptide binding]; other site
111780002385	FAD binding pocket [chemical binding]; other site
111780002386	FAD binding motif [chemical binding]; other site
111780002387	catalytic residues [active]
111780002388	NAD binding pocket [chemical binding]; other site
111780002389	phosphate binding motif [ion binding]; other site
111780002390	beta-alpha-beta structure motif; other site
111780002391	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780002392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780002393	Walker A/P-loop; other site
111780002394	ATP binding site [chemical binding]; other site
111780002395	Q-loop/lid; other site
111780002396	ABC transporter signature motif; other site
111780002397	Walker B; other site
111780002398	D-loop; other site
111780002399	H-loop/switch region; other site
111780002400	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
111780002401	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
111780002402	active site
111780002403	dimer interface [polypeptide binding]; other site
111780002404	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
111780002405	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
111780002406	Ligand Binding Site [chemical binding]; other site
111780002407	Molecular Tunnel; other site
111780002408	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
111780002409	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780002410	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780002411	AAA ATPase domain; Region: AAA_16; pfam13191
111780002412	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780002413	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
111780002414	putative ADP-binding pocket [chemical binding]; other site
111780002415	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780002416	Chain length determinant protein; Region: Wzz; cl15801
111780002417	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
111780002418	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780002419	P-loop; other site
111780002420	Magnesium ion binding site [ion binding]; other site
111780002421	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780002422	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780002423	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780002424	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
111780002425	Walker A/P-loop; other site
111780002426	ATP binding site [chemical binding]; other site
111780002427	Q-loop/lid; other site
111780002428	ABC transporter signature motif; other site
111780002429	Walker B; other site
111780002430	D-loop; other site
111780002431	H-loop/switch region; other site
111780002432	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780002433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780002434	S-adenosylmethionine binding site [chemical binding]; other site
111780002435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780002436	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780002437	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780002438	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
111780002439	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
111780002440	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
111780002441	trimer interface [polypeptide binding]; other site
111780002442	active site
111780002443	CoA binding site [chemical binding]; other site
111780002444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780002445	S-adenosylmethionine binding site [chemical binding]; other site
111780002446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780002447	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780002448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780002449	S-adenosylmethionine binding site [chemical binding]; other site
111780002450	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780002451	active site
111780002452	NTP binding site [chemical binding]; other site
111780002453	metal binding triad [ion binding]; metal-binding site
111780002454	antibiotic binding site [chemical binding]; other site
111780002455	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780002456	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
111780002457	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780002458	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780002459	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780002460	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
111780002461	protein binding site [polypeptide binding]; other site
111780002462	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
111780002463	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
111780002464	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
111780002465	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
111780002466	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
111780002467	Double zinc ribbon; Region: DZR; pfam12773
111780002468	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
111780002469	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
111780002470	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
111780002471	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
111780002472	metal binding site [ion binding]; metal-binding site
111780002473	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
111780002474	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
111780002475	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780002476	putative active site [active]
111780002477	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
111780002478	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
111780002479	ABC-ATPase subunit  interface; other site
111780002480	dimer interface [polypeptide binding]; other site
111780002481	putative PBP binding regions; other site
111780002482	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
111780002483	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780002484	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002485	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
111780002486	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
111780002487	G1 box; other site
111780002488	GTP/Mg2+ binding site [chemical binding]; other site
111780002489	Switch I region; other site
111780002490	G2 box; other site
111780002491	Switch II region; other site
111780002492	G3 box; other site
111780002493	G4 box; other site
111780002494	G5 box; other site
111780002495	Domain of unknown function (DUF697); Region: DUF697; pfam05128
111780002496	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
111780002497	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
111780002498	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
111780002499	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
111780002500	Exoribonuclease R [Transcription]; Region: VacB; COG0557
111780002501	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
111780002502	RNB domain; Region: RNB; pfam00773
111780002503	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
111780002504	RNA binding site [nucleotide binding]; other site
111780002505	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
111780002506	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
111780002507	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
111780002508	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780002509	Coenzyme A binding pocket [chemical binding]; other site
111780002510	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
111780002511	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
111780002512	Ligand binding site; other site
111780002513	Putative Catalytic site; other site
111780002514	DXD motif; other site
111780002515	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780002516	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780002517	ligand binding site [chemical binding]; other site
111780002518	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
111780002519	CHAD domain; Region: CHAD; cl10506
111780002520	photosystem I subunit IV; Reviewed; Region: psaE; CHL00125
111780002521	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
111780002522	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
111780002523	putative ADP-binding pocket [chemical binding]; other site
111780002524	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
111780002525	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
111780002526	active site
111780002527	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
111780002528	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
111780002529	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
111780002530	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
111780002531	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
111780002532	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
111780002533	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
111780002534	Surface antigen; Region: Bac_surface_Ag; pfam01103
111780002535	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
111780002536	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
111780002537	Helix-turn-helix domain; Region: HTH_17; pfam12728
111780002538	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
111780002539	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780002540	cofactor binding site; other site
111780002541	DNA binding site [nucleotide binding]
111780002542	substrate interaction site [chemical binding]; other site
111780002543	SinI restriction endonuclease; Region: RE_SinI; pfam09570
111780002544	homoserine dehydrogenase; Provisional; Region: PRK06349
111780002545	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
111780002546	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
111780002547	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
111780002548	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
111780002549	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
111780002550	HIGH motif; other site
111780002551	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
111780002552	active site
111780002553	KMSKS motif; other site
111780002554	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
111780002555	Uncharacterized conserved protein [Function unknown]; Region: COG0432
111780002556	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
111780002557	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780002558	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
111780002559	active site
111780002560	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780002561	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
111780002562	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
111780002563	C-terminal domain interface [polypeptide binding]; other site
111780002564	GSH binding site (G-site) [chemical binding]; other site
111780002565	dimer interface [polypeptide binding]; other site
111780002566	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
111780002567	N-terminal domain interface [polypeptide binding]; other site
111780002568	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780002569	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
111780002570	active site
111780002571	metal binding site [ion binding]; metal-binding site
111780002572	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
111780002573	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
111780002574	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
111780002575	trimer interface [polypeptide binding]; other site
111780002576	putative metal binding site [ion binding]; other site
111780002577	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
111780002578	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
111780002579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780002580	ATP binding site [chemical binding]; other site
111780002581	Mg2+ binding site [ion binding]; other site
111780002582	G-X-G motif; other site
111780002583	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
111780002584	ATP binding site [chemical binding]; other site
111780002585	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
111780002586	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780002587	HSP70 interaction site [polypeptide binding]; other site
111780002588	HAS barrel domain; Region: HAS-barrel; pfam09378
111780002589	HerA helicase [Replication, recombination, and repair]; Region: COG0433
111780002590	Domain of unknown function DUF87; Region: DUF87; pfam01935
111780002591	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
111780002592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780002593	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
111780002594	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
111780002595	Uncharacterized conserved protein [Function unknown]; Region: COG1656
111780002596	Protein of unknown function DUF82; Region: DUF82; pfam01927
111780002597	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
111780002598	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
111780002599	alpha subunit interface [polypeptide binding]; other site
111780002600	TPP binding site [chemical binding]; other site
111780002601	heterodimer interface [polypeptide binding]; other site
111780002602	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
111780002603	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
111780002604	S-layer homology domain; Region: SLH; pfam00395
111780002605	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780002606	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
111780002607	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
111780002608	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
111780002609	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
111780002610	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
111780002611	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
111780002612	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
111780002613	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780002614	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
111780002615	protein binding site [polypeptide binding]; other site
111780002616	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780002617	DNA binding residues [nucleotide binding]
111780002618	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
111780002619	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
111780002620	putative ADP-binding pocket [chemical binding]; other site
111780002621	Photosystem II protein; Region: PSII; cl08223
111780002622	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780002623	Mechanosensitive ion channel; Region: MS_channel; pfam00924
111780002624	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
111780002625	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
111780002626	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
111780002627	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
111780002628	glycogen binding site [chemical binding]; other site
111780002629	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
111780002630	active site
111780002631	catalytic site [active]
111780002632	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
111780002633	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
111780002634	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
111780002635	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
111780002636	[2Fe-2S] cluster binding site [ion binding]; other site
111780002637	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
111780002638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
111780002639	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780002640	alpha-glucosidase; Provisional; Region: PRK10137
111780002641	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
111780002642	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
111780002643	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780002644	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
111780002645	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
111780002646	putative ADP-binding pocket [chemical binding]; other site
111780002647	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780002648	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780002649	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780002650	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780002651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780002652	Walker A/P-loop; other site
111780002653	ATP binding site [chemical binding]; other site
111780002654	Q-loop/lid; other site
111780002655	ABC transporter signature motif; other site
111780002656	Walker B; other site
111780002657	D-loop; other site
111780002658	H-loop/switch region; other site
111780002659	Phosphotransferase enzyme family; Region: APH; pfam01636
111780002660	S-layer homology domain; Region: SLH; pfam00395
111780002661	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780002662	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780002663	sucrose synthase; Region: sucr_synth; TIGR02470
111780002664	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
111780002665	putative ADP-binding pocket [chemical binding]; other site
111780002666	phosphoenolpyruvate synthase; Validated; Region: PRK06464
111780002667	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
111780002668	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
111780002669	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
111780002670	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
111780002671	phosphatidate cytidylyltransferase; Region: PLN02953
111780002672	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
111780002673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780002674	S-adenosylmethionine binding site [chemical binding]; other site
111780002675	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
111780002676	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
111780002677	homodimer interface [polypeptide binding]; other site
111780002678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780002679	catalytic residue [active]
111780002680	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
111780002681	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780002682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002683	active site
111780002684	phosphorylation site [posttranslational modification]
111780002685	intermolecular recognition site; other site
111780002686	dimerization interface [polypeptide binding]; other site
111780002687	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780002688	DNA binding site [nucleotide binding]
111780002689	Predicted membrane protein [Function unknown]; Region: COG1950
111780002690	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
111780002691	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
111780002692	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
111780002693	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
111780002694	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780002695	OstA-like protein; Region: OstA; cl00844
111780002696	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
111780002697	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
111780002698	intersubunit interface [polypeptide binding]; other site
111780002699	active site
111780002700	zinc binding site [ion binding]; other site
111780002701	Na+ binding site [ion binding]; other site
111780002702	Uncharacterized conserved protein [Function unknown]; Region: COG1565
111780002703	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
111780002704	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
111780002705	putative active site [active]
111780002706	substrate binding site [chemical binding]; other site
111780002707	putative cosubstrate binding site; other site
111780002708	catalytic site [active]
111780002709	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
111780002710	substrate binding site [chemical binding]; other site
111780002711	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
111780002712	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
111780002713	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
111780002714	active site
111780002715	acyl carrier protein; Provisional; Region: acpP; PRK00982
111780002716	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
111780002717	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
111780002718	dimer interface [polypeptide binding]; other site
111780002719	active site
111780002720	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
111780002721	transketolase; Region: PLN02790
111780002722	TPP-binding site [chemical binding]; other site
111780002723	dimer interface [polypeptide binding]; other site
111780002724	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
111780002725	PYR/PP interface [polypeptide binding]; other site
111780002726	dimer interface [polypeptide binding]; other site
111780002727	TPP binding site [chemical binding]; other site
111780002728	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
111780002729	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
111780002730	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
111780002731	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
111780002732	Protein of unknown function (DUF751); Region: DUF751; pfam05421
111780002733	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
111780002734	ligand binding site [chemical binding]; other site
111780002735	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
111780002736	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
111780002737	Transglutaminase/protease-like homologues; Region: TGc; smart00460
111780002738	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
111780002739	catalytic residues [active]
111780002740	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
111780002741	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780002742	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002743	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002744	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002745	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002746	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002747	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780002748	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
111780002749	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
111780002750	propionate/acetate kinase; Provisional; Region: PRK12379
111780002751	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780002752	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780002753	ligand binding site [chemical binding]; other site
111780002754	flexible hinge region; other site
111780002755	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
111780002756	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
111780002757	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
111780002758	FMN binding site [chemical binding]; other site
111780002759	active site
111780002760	catalytic residues [active]
111780002761	substrate binding site [chemical binding]; other site
111780002762	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
111780002763	putative RNA binding site [nucleotide binding]; other site
111780002764	Uncharacterized conserved protein [Function unknown]; Region: COG2928
111780002765	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
111780002766	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
111780002767	Zn2+ binding site [ion binding]; other site
111780002768	Mg2+ binding site [ion binding]; other site
111780002769	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
111780002770	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
111780002771	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
111780002772	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
111780002773	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
111780002774	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780002775	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780002776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780002777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780002778	dimer interface [polypeptide binding]; other site
111780002779	phosphorylation site [posttranslational modification]
111780002780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780002781	ATP binding site [chemical binding]; other site
111780002782	Mg2+ binding site [ion binding]; other site
111780002783	G-X-G motif; other site
111780002784	Response regulator receiver domain; Region: Response_reg; pfam00072
111780002785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002786	active site
111780002787	phosphorylation site [posttranslational modification]
111780002788	dimerization interface [polypeptide binding]; other site
111780002789	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
111780002790	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
111780002791	putative active site cavity [active]
111780002792	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
111780002793	TrkA-N domain; Region: TrkA_N; pfam02254
111780002794	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780002795	TrkA-N domain; Region: TrkA_N; pfam02254
111780002796	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
111780002797	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
111780002798	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
111780002799	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
111780002800	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780002801	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
111780002802	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
111780002803	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
111780002804	TPP-binding site [chemical binding]; other site
111780002805	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
111780002806	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
111780002807	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
111780002808	CpeS-like protein; Region: CpeS; pfam09367
111780002809	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780002810	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780002811	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780002812	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
111780002813	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
111780002814	CpeS-like protein; Region: CpeS; pfam09367
111780002815	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
111780002816	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
111780002817	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
111780002818	glucokinase; Provisional; Region: glk; PRK00292
111780002819	glucokinase, proteobacterial type; Region: glk; TIGR00749
111780002820	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
111780002821	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
111780002822	G1 box; other site
111780002823	GTP/Mg2+ binding site [chemical binding]; other site
111780002824	G2 box; other site
111780002825	Switch I region; other site
111780002826	G3 box; other site
111780002827	Switch II region; other site
111780002828	G4 box; other site
111780002829	G5 box; other site
111780002830	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
111780002831	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
111780002832	putative ligand binding site [chemical binding]; other site
111780002833	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
111780002834	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
111780002835	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
111780002836	TM-ABC transporter signature motif; other site
111780002837	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
111780002838	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
111780002839	TM-ABC transporter signature motif; other site
111780002840	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
111780002841	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
111780002842	Walker A/P-loop; other site
111780002843	ATP binding site [chemical binding]; other site
111780002844	Q-loop/lid; other site
111780002845	ABC transporter signature motif; other site
111780002846	Walker B; other site
111780002847	D-loop; other site
111780002848	H-loop/switch region; other site
111780002849	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
111780002850	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
111780002851	Walker A/P-loop; other site
111780002852	ATP binding site [chemical binding]; other site
111780002853	Q-loop/lid; other site
111780002854	ABC transporter signature motif; other site
111780002855	Walker B; other site
111780002856	D-loop; other site
111780002857	H-loop/switch region; other site
111780002858	Uncharacterized conserved protein [Function unknown]; Region: COG4095
111780002859	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
111780002860	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
111780002861	active site
111780002862	metal binding site [ion binding]; metal-binding site
111780002863	DNA binding site [nucleotide binding]
111780002864	photosystem II protein K; Region: psbK; CHL00047
111780002865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
111780002866	dimerization interface [polypeptide binding]; other site
111780002867	putative DNA binding site [nucleotide binding]; other site
111780002868	putative Zn2+ binding site [ion binding]; other site
111780002869	PBP superfamily domain; Region: PBP_like_2; cl17296
111780002870	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
111780002871	arsenical-resistance protein; Region: acr3; TIGR00832
111780002872	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
111780002873	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
111780002874	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
111780002875	Low molecular weight phosphatase family; Region: LMWPc; cl00105
111780002876	active site
111780002877	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
111780002878	Low molecular weight phosphatase family; Region: LMWPc; cd00115
111780002879	active site
111780002880	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
111780002881	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
111780002882	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
111780002883	N-terminal plug; other site
111780002884	ligand-binding site [chemical binding]; other site
111780002885	NurA domain; Region: NurA; pfam09376
111780002886	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780002887	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780002888	haemagglutination activity domain; Region: Haemagg_act; pfam05860
111780002889	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
111780002890	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780002891	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780002892	Probable transposase; Region: OrfB_IS605; pfam01385
111780002893	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780002894	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780002895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780002896	Walker A/P-loop; other site
111780002897	ATP binding site [chemical binding]; other site
111780002898	Q-loop/lid; other site
111780002899	ABC transporter signature motif; other site
111780002900	Walker B; other site
111780002901	D-loop; other site
111780002902	H-loop/switch region; other site
111780002903	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780002904	PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640
111780002905	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
111780002906	active site
111780002907	metal-binding site [ion binding]
111780002908	nucleotide-binding site [chemical binding]; other site
111780002909	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780002910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780002911	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
111780002912	active site
111780002913	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
111780002914	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
111780002915	Ligand Binding Site [chemical binding]; other site
111780002916	Molecular Tunnel; other site
111780002917	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
111780002918	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
111780002919	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
111780002920	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
111780002921	Walker A/P-loop; other site
111780002922	ATP binding site [chemical binding]; other site
111780002923	Q-loop/lid; other site
111780002924	ABC transporter signature motif; other site
111780002925	Walker B; other site
111780002926	D-loop; other site
111780002927	H-loop/switch region; other site
111780002928	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
111780002929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780002930	dimer interface [polypeptide binding]; other site
111780002931	conserved gate region; other site
111780002932	putative PBP binding loops; other site
111780002933	ABC-ATPase subunit interface; other site
111780002934	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
111780002935	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
111780002936	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
111780002937	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
111780002938	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
111780002939	agmatinase; Region: agmatinase; TIGR01230
111780002940	Agmatinase-like family; Region: Agmatinase-like; cd09990
111780002941	active site
111780002942	oligomer interface [polypeptide binding]; other site
111780002943	Mn binding site [ion binding]; other site
111780002944	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
111780002945	dimer interface [polypeptide binding]; other site
111780002946	ADP-ribose binding site [chemical binding]; other site
111780002947	active site
111780002948	nudix motif; other site
111780002949	metal binding site [ion binding]; metal-binding site
111780002950	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
111780002951	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
111780002952	active site
111780002953	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
111780002954	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
111780002955	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
111780002956	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
111780002957	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
111780002958	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
111780002959	MOSC domain; Region: MOSC; pfam03473
111780002960	amidase; Provisional; Region: PRK09201
111780002961	Amidase; Region: Amidase; cl11426
111780002962	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
111780002963	TMAO/DMSO reductase; Reviewed; Region: PRK05363
111780002964	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
111780002965	Moco binding site; other site
111780002966	metal coordination site [ion binding]; other site
111780002967	recombination protein RecR; Reviewed; Region: recR; PRK00076
111780002968	RecR protein; Region: RecR; pfam02132
111780002969	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
111780002970	putative active site [active]
111780002971	putative metal-binding site [ion binding]; other site
111780002972	tetramer interface [polypeptide binding]; other site
111780002973	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780002974	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
111780002975	cofactor binding site; other site
111780002976	DNA binding site [nucleotide binding]
111780002977	substrate interaction site [chemical binding]; other site
111780002978	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
111780002979	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
111780002980	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
111780002981	homotetramer interface [polypeptide binding]; other site
111780002982	ligand binding site [chemical binding]; other site
111780002983	catalytic site [active]
111780002984	NAD binding site [chemical binding]; other site
111780002985	Predicted membrane protein [Function unknown]; Region: COG1238
111780002986	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
111780002987	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
111780002988	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
111780002989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780002990	Coenzyme A binding pocket [chemical binding]; other site
111780002991	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
111780002992	Response regulator receiver domain; Region: Response_reg; pfam00072
111780002993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780002994	active site
111780002995	phosphorylation site [posttranslational modification]
111780002996	intermolecular recognition site; other site
111780002997	dimerization interface [polypeptide binding]; other site
111780002998	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780002999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003000	active site
111780003001	phosphorylation site [posttranslational modification]
111780003002	intermolecular recognition site; other site
111780003003	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780003004	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780003005	metal binding site [ion binding]; metal-binding site
111780003006	active site
111780003007	I-site; other site
111780003008	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780003009	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
111780003010	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780003011	substrate binding pocket [chemical binding]; other site
111780003012	membrane-bound complex binding site; other site
111780003013	hinge residues; other site
111780003014	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
111780003015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
111780003016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780003017	putative PBP binding loops; other site
111780003018	dimer interface [polypeptide binding]; other site
111780003019	ABC-ATPase subunit interface; other site
111780003020	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
111780003021	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
111780003022	TPR repeat; Region: TPR_11; pfam13414
111780003023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780003024	binding surface
111780003025	TPR motif; other site
111780003026	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780003027	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
111780003028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003029	active site
111780003030	phosphorylation site [posttranslational modification]
111780003031	intermolecular recognition site; other site
111780003032	dimerization interface [polypeptide binding]; other site
111780003033	CheB methylesterase; Region: CheB_methylest; pfam01339
111780003034	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780003035	putative binding surface; other site
111780003036	active site
111780003037	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
111780003038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780003039	ATP binding site [chemical binding]; other site
111780003040	Mg2+ binding site [ion binding]; other site
111780003041	G-X-G motif; other site
111780003042	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780003043	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780003044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003045	active site
111780003046	phosphorylation site [posttranslational modification]
111780003047	intermolecular recognition site; other site
111780003048	dimerization interface [polypeptide binding]; other site
111780003049	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780003050	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780003051	dimer interface [polypeptide binding]; other site
111780003052	putative CheW interface [polypeptide binding]; other site
111780003053	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
111780003054	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780003055	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780003056	dimer interface [polypeptide binding]; other site
111780003057	putative CheW interface [polypeptide binding]; other site
111780003058	CheW-like domain; Region: CheW; pfam01584
111780003059	CheW-like domain; Region: CheW; pfam01584
111780003060	Response regulator receiver domain; Region: Response_reg; pfam00072
111780003061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003062	active site
111780003063	phosphorylation site [posttranslational modification]
111780003064	intermolecular recognition site; other site
111780003065	dimerization interface [polypeptide binding]; other site
111780003066	Predicted membrane protein [Function unknown]; Region: COG2119
111780003067	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
111780003068	Predicted membrane protein [Function unknown]; Region: COG2119
111780003069	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
111780003070	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
111780003071	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
111780003072	O-succinylbenzoate synthase; Provisional; Region: PRK02714
111780003073	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
111780003074	active site
111780003075	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
111780003076	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
111780003077	putative di-iron ligands [ion binding]; other site
111780003078	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
111780003079	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
111780003080	catalytic residues [active]
111780003081	acyl-CoA synthetase; Validated; Region: PRK05850
111780003082	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
111780003083	acyl-activating enzyme (AAE) consensus motif; other site
111780003084	active site
111780003085	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780003086	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
111780003087	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
111780003088	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
111780003089	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
111780003090	tetramer interface [polypeptide binding]; other site
111780003091	active site
111780003092	Mg2+/Mn2+ binding site [ion binding]; other site
111780003093	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
111780003094	alpha-glucosidase; Provisional; Region: PRK10137
111780003095	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
111780003096	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
111780003097	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
111780003098	substrate binding site [chemical binding]; other site
111780003099	glutamase interaction surface [polypeptide binding]; other site
111780003100	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
111780003101	Uncharacterized conserved protein [Function unknown]; Region: COG2968
111780003102	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
111780003103	Peptidase family M48; Region: Peptidase_M48; pfam01435
111780003104	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
111780003105	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
111780003106	active site
111780003107	intersubunit interface [polypeptide binding]; other site
111780003108	catalytic residue [active]
111780003109	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
111780003110	putative active site [active]
111780003111	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
111780003112	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
111780003113	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
111780003114	active site
111780003115	putative homodimer interface [polypeptide binding]; other site
111780003116	SAM binding site [chemical binding]; other site
111780003117	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
111780003118	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
111780003119	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780003120	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
111780003121	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
111780003122	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
111780003123	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
111780003124	Walker A/P-loop; other site
111780003125	ATP binding site [chemical binding]; other site
111780003126	Q-loop/lid; other site
111780003127	ABC transporter signature motif; other site
111780003128	Walker B; other site
111780003129	D-loop; other site
111780003130	H-loop/switch region; other site
111780003131	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
111780003132	putative carbohydrate binding site [chemical binding]; other site
111780003133	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
111780003134	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
111780003135	putative glycosyl transferase; Provisional; Region: PRK10125
111780003136	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780003137	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
111780003138	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
111780003139	catalytic residues [active]
111780003140	DNA adenine methylase (dam); Region: dam; TIGR00571
111780003141	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
111780003142	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
111780003143	active site
111780003144	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
111780003145	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
111780003146	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
111780003147	PIN domain; Region: PIN_3; pfam13470
111780003148	DNA binding domain, excisionase family; Region: excise; TIGR01764
111780003149	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
111780003150	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
111780003151	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780003152	YcfA-like protein; Region: YcfA; pfam07927
111780003153	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
111780003154	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
111780003155	Ligand binding site; other site
111780003156	Putative Catalytic site; other site
111780003157	DXD motif; other site
111780003158	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780003159	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780003160	Hexamer interface [polypeptide binding]; other site
111780003161	Hexagonal pore residue; other site
111780003162	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780003163	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780003164	Hexamer interface [polypeptide binding]; other site
111780003165	Hexagonal pore residue; other site
111780003166	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780003167	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
111780003168	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
111780003169	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
111780003170	ABC transporter; Region: ABC_tran_2; pfam12848
111780003171	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
111780003172	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
111780003173	active site
111780003174	catalytic triad [active]
111780003175	oxyanion hole [active]
111780003176	Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527
111780003177	Protein-arginine deiminase (PAD); Region: PAD; pfam03068
111780003178	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
111780003179	MgtE intracellular N domain; Region: MgtE_N; smart00924
111780003180	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
111780003181	Divalent cation transporter; Region: MgtE; pfam01769
111780003182	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
111780003183	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
111780003184	catalytic residues [active]
111780003185	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780003186	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780003187	ligand binding site [chemical binding]; other site
111780003188	flexible hinge region; other site
111780003189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780003190	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
111780003191	Coenzyme A binding pocket [chemical binding]; other site
111780003192	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
111780003193	ABC1 family; Region: ABC1; cl17513
111780003194	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
111780003195	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
111780003196	Walker A/P-loop; other site
111780003197	ATP binding site [chemical binding]; other site
111780003198	Q-loop/lid; other site
111780003199	ABC transporter signature motif; other site
111780003200	Walker B; other site
111780003201	D-loop; other site
111780003202	H-loop/switch region; other site
111780003203	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
111780003204	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
111780003205	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
111780003206	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
111780003207	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
111780003208	heterotetramer interface [polypeptide binding]; other site
111780003209	active site pocket [active]
111780003210	cleavage site
111780003211	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
111780003212	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780003213	putative metal binding site [ion binding]; other site
111780003214	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780003215	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780003216	active site
111780003217	catalytic tetrad [active]
111780003218	ribosomal protein S14; Region: rps14; CHL00074
111780003219	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
111780003220	AAA domain; Region: AAA_26; pfam13500
111780003221	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
111780003222	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
111780003223	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780003224	active site
111780003225	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
111780003226	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
111780003227	Catalytic site [active]
111780003228	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
111780003229	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
111780003230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780003231	S-adenosylmethionine binding site [chemical binding]; other site
111780003232	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
111780003233	Nuclease-related domain; Region: NERD; pfam08378
111780003234	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
111780003235	Family description; Region: UvrD_C_2; pfam13538
111780003236	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780003237	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780003238	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
111780003239	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
111780003240	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
111780003241	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
111780003242	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780003243	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780003244	active site
111780003245	ATP binding site [chemical binding]; other site
111780003246	substrate binding site [chemical binding]; other site
111780003247	activation loop (A-loop); other site
111780003248	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780003249	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780003250	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780003251	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780003252	TPR repeat; Region: TPR_11; pfam13414
111780003253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780003254	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
111780003255	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
111780003256	active site
111780003257	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
111780003258	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
111780003259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780003260	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
111780003261	Enoylreductase; Region: PKS_ER; smart00829
111780003262	NAD(P) binding site [chemical binding]; other site
111780003263	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
111780003264	KR domain; Region: KR; pfam08659
111780003265	putative NADP binding site [chemical binding]; other site
111780003266	active site
111780003267	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
111780003268	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
111780003269	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
111780003270	substrate-cofactor binding pocket; other site
111780003271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780003272	catalytic residue [active]
111780003273	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
111780003274	Peptidase family M48; Region: Peptidase_M48; pfam01435
111780003275	Class I aldolases; Region: Aldolase_Class_I; cl17187
111780003276	catalytic residue [active]
111780003277	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
111780003278	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
111780003279	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
111780003280	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
111780003281	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
111780003282	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780003283	P-loop; other site
111780003284	Magnesium ion binding site [ion binding]; other site
111780003285	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780003286	Magnesium ion binding site [ion binding]; other site
111780003287	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780003288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003289	active site
111780003290	phosphorylation site [posttranslational modification]
111780003291	intermolecular recognition site; other site
111780003292	dimerization interface [polypeptide binding]; other site
111780003293	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780003294	metal binding site [ion binding]; metal-binding site
111780003295	active site
111780003296	I-site; other site
111780003297	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780003298	Cache domain; Region: Cache_1; pfam02743
111780003299	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780003300	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780003301	dimerization interface [polypeptide binding]; other site
111780003302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780003303	dimer interface [polypeptide binding]; other site
111780003304	phosphorylation site [posttranslational modification]
111780003305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780003306	ATP binding site [chemical binding]; other site
111780003307	Mg2+ binding site [ion binding]; other site
111780003308	G-X-G motif; other site
111780003309	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780003310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003311	active site
111780003312	phosphorylation site [posttranslational modification]
111780003313	intermolecular recognition site; other site
111780003314	dimerization interface [polypeptide binding]; other site
111780003315	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
111780003316	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
111780003317	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
111780003318	acyl-activating enzyme (AAE) consensus motif; other site
111780003319	active site
111780003320	AMP binding site [chemical binding]; other site
111780003321	CoA binding site [chemical binding]; other site
111780003322	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780003323	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
111780003324	active site
111780003325	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
111780003326	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780003327	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
111780003328	DXD motif; other site
111780003329	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
111780003330	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
111780003331	Ferritin-like domain; Region: Ferritin; pfam00210
111780003332	dimanganese center [ion binding]; other site
111780003333	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
111780003334	pyruvate kinase; Provisional; Region: PRK06354
111780003335	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
111780003336	domain interfaces; other site
111780003337	active site
111780003338	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
111780003339	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
111780003340	apocytochrome f; Reviewed; Region: PRK02693
111780003341	cytochrome f; Region: petA; CHL00037
111780003342	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
111780003343	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
111780003344	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
111780003345	cytochrome b subunit interaction site [polypeptide binding]; other site
111780003346	[2Fe-2S] cluster binding site [ion binding]; other site
111780003347	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
111780003348	acyl-CoA synthetase; Validated; Region: PRK05850
111780003349	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
111780003350	acyl-activating enzyme (AAE) consensus motif; other site
111780003351	active site
111780003352	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780003353	Radical SAM superfamily; Region: Radical_SAM; pfam04055
111780003354	FeS/SAM binding site; other site
111780003355	4Fe-4S binding domain; Region: Fer4_5; pfam12801
111780003356	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780003357	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780003358	ligand binding site [chemical binding]; other site
111780003359	flexible hinge region; other site
111780003360	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
111780003361	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
111780003362	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
111780003363	catalytic site [active]
111780003364	active site
111780003365	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
111780003366	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
111780003367	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
111780003368	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
111780003369	active site
111780003370	catalytic site [active]
111780003371	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
111780003372	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
111780003373	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
111780003374	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780003375	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
111780003376	catalytic residue [active]
111780003377	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780003378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780003379	Probable transposase; Region: OrfB_IS605; pfam01385
111780003380	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780003381	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780003382	Coenzyme A binding pocket [chemical binding]; other site
111780003383	maltose O-acetyltransferase; Provisional; Region: PRK10092
111780003384	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
111780003385	active site
111780003386	substrate binding site [chemical binding]; other site
111780003387	trimer interface [polypeptide binding]; other site
111780003388	CoA binding site [chemical binding]; other site
111780003389	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
111780003390	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
111780003391	dimer interface [polypeptide binding]; other site
111780003392	active site
111780003393	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
111780003394	active site
111780003395	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
111780003396	Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152
111780003397	pheophytin binding site; other site
111780003398	chlorophyll binding site; other site
111780003399	quinone binding site; other site
111780003400	Fe binding site [ion binding]; other site
111780003401	photosystem II 44 kDa protein; Region: psbC; CHL00035
111780003402	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
111780003403	HEAT repeats; Region: HEAT_2; pfam13646
111780003404	HEAT repeats; Region: HEAT_2; pfam13646
111780003405	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
111780003406	HEAT repeats; Region: HEAT_2; pfam13646
111780003407	CpeS-like protein; Region: CpeS; pfam09367
111780003408	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
111780003409	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
111780003410	CHAT domain; Region: CHAT; cl17868
111780003411	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389
111780003412	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
111780003413	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780003414	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
111780003415	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
111780003416	hypothetical protein; Provisional; Region: PRK07377
111780003417	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
111780003418	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
111780003419	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
111780003420	Cl- selectivity filter; other site
111780003421	Cl- binding residues [ion binding]; other site
111780003422	pore gating glutamate residue; other site
111780003423	dimer interface [polypeptide binding]; other site
111780003424	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780003425	histidine decarboxylase; Provisional; Region: PRK02769
111780003426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780003427	catalytic residue [active]
111780003428	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
111780003429	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
111780003430	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
111780003431	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
111780003432	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
111780003433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780003434	active site
111780003435	motif I; other site
111780003436	motif II; other site
111780003437	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
111780003438	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
111780003439	30S subunit binding site; other site
111780003440	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
111780003441	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
111780003442	dimerization interface [polypeptide binding]; other site
111780003443	active site
111780003444	metal binding site [ion binding]; metal-binding site
111780003445	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
111780003446	dsRNA binding site [nucleotide binding]; other site
111780003447	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
111780003448	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780003449	Walker A motif; other site
111780003450	ATP binding site [chemical binding]; other site
111780003451	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
111780003452	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
111780003453	Protein of unknown function (DUF565); Region: DUF565; pfam04483
111780003454	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
111780003455	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780003456	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
111780003457	Walker A motif; other site
111780003458	ATP binding site [chemical binding]; other site
111780003459	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
111780003460	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
111780003461	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
111780003462	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
111780003463	active site
111780003464	zinc binding site [ion binding]; other site
111780003465	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
111780003466	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
111780003467	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
111780003468	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
111780003469	putative active site [active]
111780003470	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780003471	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780003472	Walker A/P-loop; other site
111780003473	ATP binding site [chemical binding]; other site
111780003474	Q-loop/lid; other site
111780003475	ABC transporter signature motif; other site
111780003476	Walker B; other site
111780003477	D-loop; other site
111780003478	H-loop/switch region; other site
111780003479	AAA ATPase domain; Region: AAA_16; pfam13191
111780003480	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
111780003481	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780003482	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780003483	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
111780003484	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
111780003485	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
111780003486	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
111780003487	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
111780003488	dephospho-CoA kinase; Region: TIGR00152
111780003489	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
111780003490	CoA-binding site [chemical binding]; other site
111780003491	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
111780003492	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
111780003493	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780003494	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780003495	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780003496	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
111780003497	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
111780003498	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
111780003499	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
111780003500	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
111780003501	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780003502	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
111780003503	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
111780003504	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780003505	Growth-arrest specific micro-tubule binding; Region: GAS; pfam13851
111780003506	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780003507	TrkA-N domain; Region: TrkA_N; pfam02254
111780003508	TrkA-C domain; Region: TrkA_C; pfam02080
111780003509	Sporulation related domain; Region: SPOR; cl10051
111780003510	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
111780003511	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
111780003512	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
111780003513	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
111780003514	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
111780003515	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
111780003516	Cl- selectivity filter; other site
111780003517	Cl- binding residues [ion binding]; other site
111780003518	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
111780003519	pore gating glutamate residue; other site
111780003520	dimer interface [polypeptide binding]; other site
111780003521	FOG: CBS domain [General function prediction only]; Region: COG0517
111780003522	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
111780003523	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780003524	Protein of unknown function DUF262; Region: DUF262; pfam03235
111780003525	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780003526	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
111780003527	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
111780003528	homodimer interface [polypeptide binding]; other site
111780003529	metal binding site [ion binding]; metal-binding site
111780003530	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
111780003531	homodimer interface [polypeptide binding]; other site
111780003532	active site
111780003533	putative chemical substrate binding site [chemical binding]; other site
111780003534	metal binding site [ion binding]; metal-binding site
111780003535	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
111780003536	Precorrin-8X methylmutase; Region: CbiC; pfam02570
111780003537	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
111780003538	active site
111780003539	SAM binding site [chemical binding]; other site
111780003540	homodimer interface [polypeptide binding]; other site
111780003541	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
111780003542	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
111780003543	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
111780003544	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
111780003545	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780003546	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
111780003547	active site
111780003548	VanZ like family; Region: VanZ; pfam04892
111780003549	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780003550	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780003551	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
111780003552	HicB family; Region: HicB; pfam05534
111780003553	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
111780003554	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
111780003555	NAD binding site [chemical binding]; other site
111780003556	ATP-grasp domain; Region: ATP-grasp; pfam02222
111780003557	PAS fold; Region: PAS; pfam00989
111780003558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780003559	putative active site [active]
111780003560	heme pocket [chemical binding]; other site
111780003561	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780003562	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780003563	metal binding site [ion binding]; metal-binding site
111780003564	active site
111780003565	I-site; other site
111780003566	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780003567	AAA ATPase domain; Region: AAA_16; pfam13191
111780003568	NACHT domain; Region: NACHT; pfam05729
111780003569	Walker A motif; other site
111780003570	ATP binding site [chemical binding]; other site
111780003571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780003572	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780003573	TPR motif; other site
111780003574	binding surface
111780003575	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780003576	VanZ like family; Region: VanZ; cl01971
111780003577	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
111780003578	DNA gyrase subunit A; Validated; Region: PRK05560
111780003579	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
111780003580	CAP-like domain; other site
111780003581	active site
111780003582	primary dimer interface [polypeptide binding]; other site
111780003583	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780003584	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780003585	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780003586	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780003587	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780003588	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
111780003589	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
111780003590	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
111780003591	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
111780003592	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
111780003593	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
111780003594	substrate-cofactor binding pocket; other site
111780003595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780003596	catalytic residue [active]
111780003597	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
111780003598	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
111780003599	dimer interface [polypeptide binding]; other site
111780003600	active site
111780003601	catalytic residue [active]
111780003602	metal binding site [ion binding]; metal-binding site
111780003603	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780003604	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780003605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780003606	S-adenosylmethionine binding site [chemical binding]; other site
111780003607	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780003608	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
111780003609	Coenzyme A binding pocket [chemical binding]; other site
111780003610	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
111780003611	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
111780003612	DHH family; Region: DHH; pfam01368
111780003613	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
111780003614	FOG: CBS domain [General function prediction only]; Region: COG0517
111780003615	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
111780003616	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
111780003617	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
111780003618	active site
111780003619	NTP binding site [chemical binding]; other site
111780003620	metal binding triad [ion binding]; metal-binding site
111780003621	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
111780003622	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
111780003623	citrate synthase; Provisional; Region: PRK14036
111780003624	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
111780003625	dimer interface [polypeptide binding]; other site
111780003626	active site
111780003627	citrylCoA binding site [chemical binding]; other site
111780003628	oxalacetate/citrate binding site [chemical binding]; other site
111780003629	coenzyme A binding site [chemical binding]; other site
111780003630	catalytic triad [active]
111780003631	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
111780003632	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
111780003633	E3 interaction surface; other site
111780003634	lipoyl attachment site [posttranslational modification]; other site
111780003635	e3 binding domain; Region: E3_binding; pfam02817
111780003636	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
111780003637	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
111780003638	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
111780003639	Response regulator receiver domain; Region: Response_reg; pfam00072
111780003640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003641	active site
111780003642	phosphorylation site [posttranslational modification]
111780003643	intermolecular recognition site; other site
111780003644	dimerization interface [polypeptide binding]; other site
111780003645	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780003646	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780003647	PAS fold; Region: PAS_4; pfam08448
111780003648	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780003649	putative active site [active]
111780003650	heme pocket [chemical binding]; other site
111780003651	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780003652	GAF domain; Region: GAF; pfam01590
111780003653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780003654	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780003655	putative active site [active]
111780003656	heme pocket [chemical binding]; other site
111780003657	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780003658	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780003659	putative active site [active]
111780003660	heme pocket [chemical binding]; other site
111780003661	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780003662	dimer interface [polypeptide binding]; other site
111780003663	phosphorylation site [posttranslational modification]
111780003664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780003665	ATP binding site [chemical binding]; other site
111780003666	Mg2+ binding site [ion binding]; other site
111780003667	G-X-G motif; other site
111780003668	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780003669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003670	active site
111780003671	phosphorylation site [posttranslational modification]
111780003672	intermolecular recognition site; other site
111780003673	dimerization interface [polypeptide binding]; other site
111780003674	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780003675	DNA binding site [nucleotide binding]
111780003676	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780003677	putative binding surface; other site
111780003678	active site
111780003679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003680	active site
111780003681	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
111780003682	phosphorylation site [posttranslational modification]
111780003683	intermolecular recognition site; other site
111780003684	dimerization interface [polypeptide binding]; other site
111780003685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003686	active site
111780003687	phosphorylation site [posttranslational modification]
111780003688	intermolecular recognition site; other site
111780003689	dimerization interface [polypeptide binding]; other site
111780003690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780003691	metal binding site [ion binding]; metal-binding site
111780003692	active site
111780003693	I-site; other site
111780003694	replicative DNA helicase; Region: DnaB; TIGR00665
111780003695	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
111780003696	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
111780003697	Walker A motif; other site
111780003698	ATP binding site [chemical binding]; other site
111780003699	Walker B motif; other site
111780003700	DNA binding loops [nucleotide binding]
111780003701	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780003702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003703	active site
111780003704	phosphorylation site [posttranslational modification]
111780003705	intermolecular recognition site; other site
111780003706	dimerization interface [polypeptide binding]; other site
111780003707	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780003708	DNA binding site [nucleotide binding]
111780003709	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780003710	putative binding surface; other site
111780003711	active site
111780003712	Response regulator receiver domain; Region: Response_reg; pfam00072
111780003713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003714	active site
111780003715	phosphorylation site [posttranslational modification]
111780003716	intermolecular recognition site; other site
111780003717	dimerization interface [polypeptide binding]; other site
111780003718	Response regulator receiver domain; Region: Response_reg; pfam00072
111780003719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003720	active site
111780003721	phosphorylation site [posttranslational modification]
111780003722	intermolecular recognition site; other site
111780003723	dimerization interface [polypeptide binding]; other site
111780003724	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
111780003725	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
111780003726	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780003727	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
111780003728	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780003729	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
111780003730	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
111780003731	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
111780003732	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
111780003733	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780003734	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780003735	Probable transposase; Region: OrfB_IS605; pfam01385
111780003736	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780003737	Protein kinase domain; Region: Pkinase; pfam00069
111780003738	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780003739	active site
111780003740	ATP binding site [chemical binding]; other site
111780003741	substrate binding site [chemical binding]; other site
111780003742	activation loop (A-loop); other site
111780003743	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780003744	Protein kinase domain; Region: Pkinase; pfam00069
111780003745	active site
111780003746	ATP binding site [chemical binding]; other site
111780003747	substrate binding site [chemical binding]; other site
111780003748	activation loop (A-loop); other site
111780003749	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780003750	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780003751	binding surface
111780003752	TPR motif; other site
111780003753	TPR repeat; Region: TPR_11; pfam13414
111780003754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780003755	binding surface
111780003756	TPR motif; other site
111780003757	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780003758	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780003759	binding surface
111780003760	TPR motif; other site
111780003761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780003762	binding surface
111780003763	TPR motif; other site
111780003764	Fasciclin domain; Region: Fasciclin; pfam02469
111780003765	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
111780003766	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780003767	allophycocyanin beta subunit; Region: apcB; CHL00088
111780003768	Phycobilisome protein; Region: Phycobilisome; cl08227
111780003769	phycobillisome linker protein; Region: apcE; CHL00091
111780003770	Phycobilisome protein; Region: Phycobilisome; cl08227
111780003771	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780003772	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780003773	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780003774	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
111780003775	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
111780003776	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780003777	catalytic residue [active]
111780003778	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
111780003779	FeS assembly protein SufD; Region: sufD; TIGR01981
111780003780	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
111780003781	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
111780003782	Walker A/P-loop; other site
111780003783	ATP binding site [chemical binding]; other site
111780003784	Q-loop/lid; other site
111780003785	ABC transporter signature motif; other site
111780003786	Walker B; other site
111780003787	D-loop; other site
111780003788	H-loop/switch region; other site
111780003789	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
111780003790	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
111780003791	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
111780003792	putative active site [active]
111780003793	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
111780003794	UbiA prenyltransferase family; Region: UbiA; pfam01040
111780003795	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780003796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003797	active site
111780003798	phosphorylation site [posttranslational modification]
111780003799	intermolecular recognition site; other site
111780003800	dimerization interface [polypeptide binding]; other site
111780003801	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780003802	DNA binding site [nucleotide binding]
111780003803	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
111780003804	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
111780003805	putative catalytic residue [active]
111780003806	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
111780003807	catalytic center binding site [active]
111780003808	ATP binding site [chemical binding]; other site
111780003809	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
111780003810	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
111780003811	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
111780003812	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
111780003813	putative phosphate acyltransferase; Provisional; Region: PRK05331
111780003814	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
111780003815	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
111780003816	dimer interface [polypeptide binding]; other site
111780003817	active site
111780003818	CoA binding pocket [chemical binding]; other site
111780003819	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
111780003820	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
111780003821	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
111780003822	Uncharacterized protein involved in cysteine biosynthesis [Amino acid transport and metabolism]; Region: CysZ; COG2981
111780003823	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
111780003824	classical (c) SDRs; Region: SDR_c; cd05233
111780003825	NAD(P) binding site [chemical binding]; other site
111780003826	active site
111780003827	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
111780003828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
111780003829	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780003830	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780003831	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
111780003832	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
111780003833	dimer interface [polypeptide binding]; other site
111780003834	anticodon binding site; other site
111780003835	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
111780003836	homodimer interface [polypeptide binding]; other site
111780003837	motif 1; other site
111780003838	active site
111780003839	motif 2; other site
111780003840	GAD domain; Region: GAD; pfam02938
111780003841	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
111780003842	active site
111780003843	motif 3; other site
111780003844	Protein of function (DUF2518); Region: DUF2518; pfam10726
111780003845	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
111780003846	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
111780003847	domain interfaces; other site
111780003848	active site
111780003849	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
111780003850	DHH family; Region: DHH; pfam01368
111780003851	DHHA1 domain; Region: DHHA1; pfam02272
111780003852	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
111780003853	Sodium Bile acid symporter family; Region: SBF; cl17470
111780003854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780003855	Probable transposase; Region: OrfB_IS605; pfam01385
111780003856	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780003857	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780003858	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
111780003859	hydrophobic ligand binding site; other site
111780003860	Conserved TM helix; Region: TM_helix; pfam05552
111780003861	Conserved TM helix; Region: TM_helix; pfam05552
111780003862	Conserved TM helix; Region: TM_helix; pfam05552
111780003863	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780003864	Ligand Binding Site [chemical binding]; other site
111780003865	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
111780003866	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780003867	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
111780003868	Uncharacterized conserved protein [Function unknown]; Region: COG1434
111780003869	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
111780003870	putative active site [active]
111780003871	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
111780003872	proposed catalytic triad [active]
111780003873	active site nucleophile [active]
111780003874	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
111780003875	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780003876	active site
111780003877	Putative methyltransferase; Region: Methyltransf_4; cl17290
111780003878	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780003879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780003880	S-adenosylmethionine binding site [chemical binding]; other site
111780003881	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
111780003882	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780003883	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780003884	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780003885	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780003886	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
111780003887	cyclase homology domain; Region: CHD; cd07302
111780003888	nucleotidyl binding site; other site
111780003889	metal binding site [ion binding]; metal-binding site
111780003890	dimer interface [polypeptide binding]; other site
111780003891	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
111780003892	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780003893	Coenzyme A binding pocket [chemical binding]; other site
111780003894	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
111780003895	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
111780003896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780003897	dimer interface [polypeptide binding]; other site
111780003898	conserved gate region; other site
111780003899	putative PBP binding loops; other site
111780003900	ABC-ATPase subunit interface; other site
111780003901	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
111780003902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780003903	dimer interface [polypeptide binding]; other site
111780003904	conserved gate region; other site
111780003905	putative PBP binding loops; other site
111780003906	ABC-ATPase subunit interface; other site
111780003907	Predicted permeases [General function prediction only]; Region: COG0701
111780003908	TIGR03943 family protein; Region: TIGR03943
111780003909	Bacterial Ig-like domain; Region: Big_5; pfam13205
111780003910	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780003911	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
111780003912	Coenzyme A binding pocket [chemical binding]; other site
111780003913	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
111780003914	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780003915	FeS/SAM binding site; other site
111780003916	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
111780003917	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
111780003918	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
111780003919	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
111780003920	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780003921	putative ADP-binding pocket [chemical binding]; other site
111780003922	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780003923	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780003924	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
111780003925	Walker A/P-loop; other site
111780003926	ATP binding site [chemical binding]; other site
111780003927	Q-loop/lid; other site
111780003928	ABC transporter signature motif; other site
111780003929	Walker B; other site
111780003930	D-loop; other site
111780003931	H-loop/switch region; other site
111780003932	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
111780003933	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
111780003934	putative Iron-sulfur protein interface [polypeptide binding]; other site
111780003935	proximal heme binding site [chemical binding]; other site
111780003936	distal heme binding site [chemical binding]; other site
111780003937	putative dimer interface [polypeptide binding]; other site
111780003938	Response regulator receiver domain; Region: Response_reg; pfam00072
111780003939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780003940	active site
111780003941	phosphorylation site [posttranslational modification]
111780003942	intermolecular recognition site; other site
111780003943	dimerization interface [polypeptide binding]; other site
111780003944	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
111780003945	catalytic residues [active]
111780003946	dimer interface [polypeptide binding]; other site
111780003947	Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152
111780003948	pheophytin binding site; other site
111780003949	chlorophyll binding site; other site
111780003950	quinone binding site; other site
111780003951	Fe binding site [ion binding]; other site
111780003952	hypothetical protein; Provisional; Region: PRK13683
111780003953	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
111780003954	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
111780003955	Walker A/P-loop; other site
111780003956	ATP binding site [chemical binding]; other site
111780003957	Q-loop/lid; other site
111780003958	ABC transporter signature motif; other site
111780003959	Walker B; other site
111780003960	D-loop; other site
111780003961	H-loop/switch region; other site
111780003962	YacP-like NYN domain; Region: NYN_YacP; pfam05991
111780003963	ornithine carbamoyltransferase; Provisional; Region: PRK00779
111780003964	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
111780003965	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
111780003966	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
111780003967	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
111780003968	NAD binding site [chemical binding]; other site
111780003969	homodimer interface [polypeptide binding]; other site
111780003970	active site
111780003971	substrate binding site [chemical binding]; other site
111780003972	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780003973	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780003974	structural tetrad; other site
111780003975	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
111780003976	ADP-ribose binding site [chemical binding]; other site
111780003977	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
111780003978	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
111780003979	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
111780003980	active site
111780003981	HIGH motif; other site
111780003982	nucleotide binding site [chemical binding]; other site
111780003983	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
111780003984	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
111780003985	active site
111780003986	KMSKS motif; other site
111780003987	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
111780003988	tRNA binding surface [nucleotide binding]; other site
111780003989	anticodon binding site; other site
111780003990	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
111780003991	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
111780003992	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
111780003993	putative dimer interface [polypeptide binding]; other site
111780003994	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
111780003995	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
111780003996	quinone interaction residues [chemical binding]; other site
111780003997	active site
111780003998	catalytic residues [active]
111780003999	FMN binding site [chemical binding]; other site
111780004000	substrate binding site [chemical binding]; other site
111780004001	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
111780004002	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780004003	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780004004	active site
111780004005	ATP binding site [chemical binding]; other site
111780004006	substrate binding site [chemical binding]; other site
111780004007	activation loop (A-loop); other site
111780004008	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
111780004009	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
111780004010	Walker A/P-loop; other site
111780004011	ATP binding site [chemical binding]; other site
111780004012	Q-loop/lid; other site
111780004013	ABC transporter signature motif; other site
111780004014	Walker B; other site
111780004015	D-loop; other site
111780004016	H-loop/switch region; other site
111780004017	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
111780004018	oligomeric interface; other site
111780004019	putative active site [active]
111780004020	homodimer interface [polypeptide binding]; other site
111780004021	DevC protein; Region: devC; TIGR01185
111780004022	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
111780004023	FtsX-like permease family; Region: FtsX; pfam02687
111780004024	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
111780004025	Peptidase family M23; Region: Peptidase_M23; pfam01551
111780004026	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780004027	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
111780004028	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
111780004029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
111780004030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
111780004031	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
111780004032	putative hydrophobic ligand binding site [chemical binding]; other site
111780004033	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
111780004034	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
111780004035	putative active site [active]
111780004036	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780004037	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
111780004038	Walker A/P-loop; other site
111780004039	ATP binding site [chemical binding]; other site
111780004040	Q-loop/lid; other site
111780004041	ABC transporter signature motif; other site
111780004042	Walker B; other site
111780004043	D-loop; other site
111780004044	H-loop/switch region; other site
111780004045	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
111780004046	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780004047	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780004048	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
111780004049	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
111780004050	dimerization interface [polypeptide binding]; other site
111780004051	DPS ferroxidase diiron center [ion binding]; other site
111780004052	ion pore; other site
111780004053	ChaB; Region: ChaB; pfam06150
111780004054	Rubredoxin [Energy production and conversion]; Region: COG1773
111780004055	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
111780004056	iron binding site [ion binding]; other site
111780004057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
111780004058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
111780004059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
111780004060	geranylgeranyl reductase; Region: ChlP; TIGR02028
111780004061	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
111780004062	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
111780004063	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
111780004064	CheB methylesterase; Region: CheB_methylest; pfam01339
111780004065	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
111780004066	Family description; Region: UvrD_C_2; pfam13538
111780004067	Family description; Region: UvrD_C_2; pfam13538
111780004068	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
111780004069	Bacterial SH3 domain homologues; Region: SH3b; smart00287
111780004070	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
111780004071	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
111780004072	active site
111780004073	metal binding site [ion binding]; metal-binding site
111780004074	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
111780004075	putative metal binding site [ion binding]; other site
111780004076	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
111780004077	putative metal binding site [ion binding]; other site
111780004078	Radical SAM superfamily; Region: Radical_SAM; pfam04055
111780004079	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780004080	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
111780004081	putative NAD(P) binding site [chemical binding]; other site
111780004082	active site
111780004083	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
111780004084	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
111780004085	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
111780004086	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
111780004087	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
111780004088	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
111780004089	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
111780004090	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780004091	active site
111780004092	metal binding site [ion binding]; metal-binding site
111780004093	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
111780004094	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
111780004095	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
111780004096	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
111780004097	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
111780004098	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
111780004099	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
111780004100	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
111780004101	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
111780004102	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780004103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780004104	S-adenosylmethionine binding site [chemical binding]; other site
111780004105	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780004106	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780004107	active site
111780004108	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
111780004109	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
111780004110	Ligand binding site; other site
111780004111	Putative Catalytic site; other site
111780004112	DXD motif; other site
111780004113	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
111780004114	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
111780004115	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780004116	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
111780004117	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
111780004118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780004119	Walker A/P-loop; other site
111780004120	ATP binding site [chemical binding]; other site
111780004121	Q-loop/lid; other site
111780004122	ABC transporter signature motif; other site
111780004123	Walker B; other site
111780004124	D-loop; other site
111780004125	H-loop/switch region; other site
111780004126	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
111780004127	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
111780004128	putative dimer interface [polypeptide binding]; other site
111780004129	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
111780004130	FAD binding domain; Region: FAD_binding_4; pfam01565
111780004131	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
111780004132	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
111780004133	Cysteine-rich domain; Region: CCG; pfam02754
111780004134	Cysteine-rich domain; Region: CCG; pfam02754
111780004135	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780004136	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780004137	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
111780004138	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
111780004139	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
111780004140	dimer interface [polypeptide binding]; other site
111780004141	motif 1; other site
111780004142	active site
111780004143	motif 2; other site
111780004144	motif 3; other site
111780004145	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
111780004146	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
111780004147	proline aminopeptidase P II; Provisional; Region: PRK10879
111780004148	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
111780004149	active site
111780004150	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
111780004151	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
111780004152	putative ABC transporter; Region: ycf24; CHL00085
111780004153	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780004154	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780004155	active site
111780004156	ATP binding site [chemical binding]; other site
111780004157	substrate binding site [chemical binding]; other site
111780004158	activation loop (A-loop); other site
111780004159	PBP superfamily domain; Region: PBP_like_2; pfam12849
111780004160	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
111780004161	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
111780004162	active site
111780004163	dimerization interface [polypeptide binding]; other site
111780004164	Staphylococcal nuclease homologues; Region: SNc; smart00318
111780004165	Catalytic site; other site
111780004166	Staphylococcal nuclease homologue; Region: SNase; pfam00565
111780004167	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780004168	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780004169	catalytic loop [active]
111780004170	iron binding site [ion binding]; other site
111780004171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
111780004172	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780004173	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780004174	Probable transposase; Region: OrfB_IS605; pfam01385
111780004175	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780004176	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780004177	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
111780004178	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780004179	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780004180	Hexamer interface [polypeptide binding]; other site
111780004181	Hexagonal pore residue; other site
111780004182	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
111780004183	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
111780004184	Hexamer interface [polypeptide binding]; other site
111780004185	Hexagonal pore residue; other site
111780004186	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
111780004187	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
111780004188	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
111780004189	Domain of unknown function DUF21; Region: DUF21; pfam01595
111780004190	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
111780004191	Transporter associated domain; Region: CorC_HlyC; smart01091
111780004192	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
111780004193	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
111780004194	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780004195	dimerization interface [polypeptide binding]; other site
111780004196	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780004197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004198	putative active site [active]
111780004199	heme pocket [chemical binding]; other site
111780004200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780004201	dimer interface [polypeptide binding]; other site
111780004202	phosphorylation site [posttranslational modification]
111780004203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780004204	ATP binding site [chemical binding]; other site
111780004205	Mg2+ binding site [ion binding]; other site
111780004206	G-X-G motif; other site
111780004207	Iron permease FTR1 family; Region: FTR1; cl00475
111780004208	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
111780004209	CHASE2 domain; Region: CHASE2; pfam05226
111780004210	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780004211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780004212	metal binding site [ion binding]; metal-binding site
111780004213	active site
111780004214	I-site; other site
111780004215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780004216	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
111780004217	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
111780004218	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780004219	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780004220	Chain length determinant protein; Region: Wzz; pfam02706
111780004221	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
111780004222	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780004223	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780004224	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
111780004225	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
111780004226	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
111780004227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780004228	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
111780004229	O-Antigen ligase; Region: Wzy_C; pfam04932
111780004230	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
111780004231	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780004232	NAD binding site [chemical binding]; other site
111780004233	homotetramer interface [polypeptide binding]; other site
111780004234	homodimer interface [polypeptide binding]; other site
111780004235	active site
111780004236	substrate binding site [chemical binding]; other site
111780004237	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780004238	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780004239	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
111780004240	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
111780004241	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
111780004242	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
111780004243	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
111780004244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780004245	active site
111780004246	motif I; other site
111780004247	motif II; other site
111780004248	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
111780004249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780004250	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780004251	Probable transposase; Region: OrfB_IS605; pfam01385
111780004252	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780004253	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
111780004254	histidinol dehydrogenase; Region: hisD; TIGR00069
111780004255	NAD binding site [chemical binding]; other site
111780004256	dimerization interface [polypeptide binding]; other site
111780004257	product binding site; other site
111780004258	substrate binding site [chemical binding]; other site
111780004259	zinc binding site [ion binding]; other site
111780004260	catalytic residues [active]
111780004261	ribosomal protein S20; Region: rps20; CHL00102
111780004262	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
111780004263	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
111780004264	active site
111780004265	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
111780004266	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
111780004267	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
111780004268	RPB1 interaction site [polypeptide binding]; other site
111780004269	RPB10 interaction site [polypeptide binding]; other site
111780004270	RPB11 interaction site [polypeptide binding]; other site
111780004271	RPB3 interaction site [polypeptide binding]; other site
111780004272	RPB12 interaction site [polypeptide binding]; other site
111780004273	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
111780004274	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
111780004275	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
111780004276	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
111780004277	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
111780004278	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
111780004279	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
111780004280	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
111780004281	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
111780004282	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
111780004283	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
111780004284	DNA binding site [nucleotide binding]
111780004285	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
111780004286	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
111780004287	putative homodimer interface [polypeptide binding]; other site
111780004288	putative homotetramer interface [polypeptide binding]; other site
111780004289	putative metal binding site [ion binding]; other site
111780004290	putative homodimer-homodimer interface [polypeptide binding]; other site
111780004291	putative allosteric switch controlling residues; other site
111780004292	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
111780004293	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
111780004294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780004295	dimer interface [polypeptide binding]; other site
111780004296	conserved gate region; other site
111780004297	putative PBP binding loops; other site
111780004298	ABC-ATPase subunit interface; other site
111780004299	hydroxyglutarate oxidase; Provisional; Region: PRK11728
111780004300	Predicted dehydrogenase [General function prediction only]; Region: COG0579
111780004301	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780004302	Methyltransferase domain; Region: Methyltransf_12; pfam08242
111780004303	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
111780004304	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
111780004305	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780004306	Methyltransferase domain; Region: Methyltransf_12; pfam08242
111780004307	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
111780004308	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780004309	extended (e) SDRs; Region: SDR_e; cd08946
111780004310	NAD(P) binding site [chemical binding]; other site
111780004311	active site
111780004312	substrate binding site [chemical binding]; other site
111780004313	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
111780004314	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
111780004315	substrate binding site; other site
111780004316	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
111780004317	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
111780004318	Protein kinase domain; Region: Pkinase; pfam00069
111780004319	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780004320	active site
111780004321	ATP binding site [chemical binding]; other site
111780004322	substrate binding site [chemical binding]; other site
111780004323	activation loop (A-loop); other site
111780004324	AAA ATPase domain; Region: AAA_16; pfam13191
111780004325	Predicted ATPase [General function prediction only]; Region: COG3899
111780004326	Walker A motif; other site
111780004327	ATP binding site [chemical binding]; other site
111780004328	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780004329	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780004330	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780004331	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780004332	metal binding site [ion binding]; metal-binding site
111780004333	active site
111780004334	I-site; other site
111780004335	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
111780004336	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780004337	putative ADP-binding pocket [chemical binding]; other site
111780004338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004339	binding surface
111780004340	TPR motif; other site
111780004341	HEAT repeats; Region: HEAT_2; pfam13646
111780004342	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
111780004343	EamA-like transporter family; Region: EamA; pfam00892
111780004344	EamA-like transporter family; Region: EamA; pfam00892
111780004345	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
111780004346	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
111780004347	tandem repeat interface [polypeptide binding]; other site
111780004348	oligomer interface [polypeptide binding]; other site
111780004349	active site residues [active]
111780004350	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
111780004351	homotrimer interaction site [polypeptide binding]; other site
111780004352	active site
111780004353	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
111780004354	Strictosidine synthase; Region: Str_synth; pfam03088
111780004355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780004356	Probable transposase; Region: OrfB_IS605; pfam01385
111780004357	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
111780004358	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
111780004359	putative catalytic residues [active]
111780004360	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
111780004361	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
111780004362	Walker A/P-loop; other site
111780004363	ATP binding site [chemical binding]; other site
111780004364	Q-loop/lid; other site
111780004365	ABC transporter signature motif; other site
111780004366	Walker B; other site
111780004367	D-loop; other site
111780004368	H-loop/switch region; other site
111780004369	TOBE domain; Region: TOBE_2; pfam08402
111780004370	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
111780004371	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
111780004372	active site
111780004373	catalytic motif [active]
111780004374	Zn binding site [ion binding]; other site
111780004375	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
111780004376	nitrilase; Region: PLN02798
111780004377	putative active site [active]
111780004378	catalytic triad [active]
111780004379	dimer interface [polypeptide binding]; other site
111780004380	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
111780004381	DDE superfamily endonuclease; Region: DDE_5; cl17874
111780004382	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
111780004383	Replication initiation factor; Region: Rep_trans; pfam02486
111780004384	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
111780004385	active site
111780004386	catalytic residues [active]
111780004387	DNA binding site [nucleotide binding]
111780004388	Int/Topo IB signature motif; other site
111780004389	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
111780004390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780004391	dimer interface [polypeptide binding]; other site
111780004392	conserved gate region; other site
111780004393	putative PBP binding loops; other site
111780004394	ABC-ATPase subunit interface; other site
111780004395	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
111780004396	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
111780004397	Dehydroquinase class II; Region: DHquinase_II; pfam01220
111780004398	active site
111780004399	trimer interface [polypeptide binding]; other site
111780004400	dimer interface [polypeptide binding]; other site
111780004401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
111780004402	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
111780004403	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
111780004404	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
111780004405	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
111780004406	PAS fold; Region: PAS_4; pfam08448
111780004407	PAS domain S-box; Region: sensory_box; TIGR00229
111780004408	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004409	putative active site [active]
111780004410	heme pocket [chemical binding]; other site
111780004411	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780004412	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780004413	metal binding site [ion binding]; metal-binding site
111780004414	active site
111780004415	I-site; other site
111780004416	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780004417	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
111780004418	putative active site [active]
111780004419	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
111780004420	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
111780004421	Catalytic site [active]
111780004422	dihydrodipicolinate reductase; Provisional; Region: PRK00048
111780004423	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
111780004424	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
111780004425	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
111780004426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
111780004427	Histidine kinase; Region: HisKA_2; pfam07568
111780004428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780004429	ATP binding site [chemical binding]; other site
111780004430	Mg2+ binding site [ion binding]; other site
111780004431	G-X-G motif; other site
111780004432	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
111780004433	Precorrin-8X methylmutase; Region: CbiC; pfam02570
111780004434	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
111780004435	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
111780004436	active site
111780004437	ATP binding site [chemical binding]; other site
111780004438	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
111780004439	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
111780004440	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
111780004441	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
111780004442	NMT1-like family; Region: NMT1_2; pfam13379
111780004443	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
111780004444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780004445	putative PBP binding loops; other site
111780004446	dimer interface [polypeptide binding]; other site
111780004447	ABC-ATPase subunit interface; other site
111780004448	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
111780004449	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
111780004450	Walker A/P-loop; other site
111780004451	ATP binding site [chemical binding]; other site
111780004452	Q-loop/lid; other site
111780004453	ABC transporter signature motif; other site
111780004454	Walker B; other site
111780004455	D-loop; other site
111780004456	H-loop/switch region; other site
111780004457	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
111780004458	NMT1-like family; Region: NMT1_2; pfam13379
111780004459	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
111780004460	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
111780004461	Walker A/P-loop; other site
111780004462	ATP binding site [chemical binding]; other site
111780004463	Q-loop/lid; other site
111780004464	ABC transporter signature motif; other site
111780004465	Walker B; other site
111780004466	D-loop; other site
111780004467	H-loop/switch region; other site
111780004468	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
111780004469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780004470	putative substrate translocation pore; other site
111780004471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780004472	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
111780004473	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
111780004474	[4Fe-4S] binding site [ion binding]; other site
111780004475	molybdopterin cofactor binding site; other site
111780004476	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
111780004477	molybdopterin cofactor binding site; other site
111780004478	signal recognition particle protein; Provisional; Region: PRK10867
111780004479	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
111780004480	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
111780004481	GTP binding site [chemical binding]; other site
111780004482	Signal peptide binding domain; Region: SRP_SPB; pfam02978
111780004483	ribosomal protein S16; Region: rps16; CHL00005
111780004484	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
111780004485	KH domain; Region: KH_4; pfam13083
111780004486	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
111780004487	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
111780004488	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
111780004489	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780004490	Thf1-like protein; Reviewed; Region: PRK13266
111780004491	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
111780004492	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780004493	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
111780004494	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
111780004495	Ligand Binding Site [chemical binding]; other site
111780004496	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780004497	Ligand Binding Site [chemical binding]; other site
111780004498	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780004499	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
111780004500	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
111780004501	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
111780004502	Sulfate transporter family; Region: Sulfate_transp; pfam00916
111780004503	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
111780004504	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780004505	Phycobilisome protein; Region: Phycobilisome; cl08227
111780004506	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
111780004507	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
111780004508	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
111780004509	dinuclear metal binding motif [ion binding]; other site
111780004510	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780004511	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
111780004512	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780004513	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
111780004514	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
111780004515	active site
111780004516	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780004517	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
111780004518	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
111780004519	NADP-binding site; other site
111780004520	homotetramer interface [polypeptide binding]; other site
111780004521	substrate binding site [chemical binding]; other site
111780004522	homodimer interface [polypeptide binding]; other site
111780004523	active site
111780004524	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
111780004525	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780004526	Response regulator receiver domain; Region: Response_reg; pfam00072
111780004527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004528	active site
111780004529	phosphorylation site [posttranslational modification]
111780004530	intermolecular recognition site; other site
111780004531	dimerization interface [polypeptide binding]; other site
111780004532	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780004533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004534	active site
111780004535	phosphorylation site [posttranslational modification]
111780004536	intermolecular recognition site; other site
111780004537	dimerization interface [polypeptide binding]; other site
111780004538	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780004539	DNA binding site [nucleotide binding]
111780004540	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780004541	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780004542	dimerization interface [polypeptide binding]; other site
111780004543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780004544	dimer interface [polypeptide binding]; other site
111780004545	phosphorylation site [posttranslational modification]
111780004546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780004547	ATP binding site [chemical binding]; other site
111780004548	Mg2+ binding site [ion binding]; other site
111780004549	G-X-G motif; other site
111780004550	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780004551	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
111780004552	putative NAD(P) binding site [chemical binding]; other site
111780004553	active site
111780004554	putative substrate binding site [chemical binding]; other site
111780004555	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
111780004556	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004557	binding surface
111780004558	TPR motif; other site
111780004559	TPR repeat; Region: TPR_11; pfam13414
111780004560	TPR repeat; Region: TPR_11; pfam13414
111780004561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004562	TPR motif; other site
111780004563	binding surface
111780004564	TPR repeat; Region: TPR_11; pfam13414
111780004565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004566	binding surface
111780004567	TPR motif; other site
111780004568	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780004569	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
111780004570	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
111780004571	Walker A/P-loop; other site
111780004572	ATP binding site [chemical binding]; other site
111780004573	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
111780004574	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
111780004575	ABC transporter signature motif; other site
111780004576	Walker B; other site
111780004577	D-loop; other site
111780004578	H-loop/switch region; other site
111780004579	MraW methylase family; Region: Methyltransf_5; cl17771
111780004580	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
111780004581	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
111780004582	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780004583	ATP-grasp domain; Region: ATP-grasp_4; cl17255
111780004584	tellurium resistance terB-like protein; Region: terB_like; cd07177
111780004585	metal binding site [ion binding]; metal-binding site
111780004586	16S rRNA methyltransferase B; Provisional; Region: PRK14901
111780004587	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
111780004588	putative RNA binding site [nucleotide binding]; other site
111780004589	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780004590	S-adenosylmethionine binding site [chemical binding]; other site
111780004591	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
111780004592	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
111780004593	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
111780004594	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780004595	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
111780004596	anthranilate synthase component I-like protein; Validated; Region: PRK05940
111780004597	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
111780004598	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
111780004599	plastocyanin; Provisional; Region: PRK02710
111780004600	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
111780004601	cytochrome c6; Provisional; Region: PRK13697
111780004602	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
111780004603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004604	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780004605	TPR motif; other site
111780004606	binding surface
111780004607	TPR repeat; Region: TPR_11; pfam13414
111780004608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004609	TPR motif; other site
111780004610	binding surface
111780004611	TPR repeat; Region: TPR_11; pfam13414
111780004612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780004613	binding surface
111780004614	TPR motif; other site
111780004615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004616	TPR motif; other site
111780004617	TPR repeat; Region: TPR_11; pfam13414
111780004618	binding surface
111780004619	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780004620	binding surface
111780004621	TPR motif; other site
111780004622	TPR repeat; Region: TPR_11; pfam13414
111780004623	Tetratricopeptide repeat; Region: TPR_9; pfam13371
111780004624	Transposase IS200 like; Region: Y1_Tnp; cl00848
111780004625	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
111780004626	Clp amino terminal domain; Region: Clp_N; pfam02861
111780004627	Clp amino terminal domain; Region: Clp_N; pfam02861
111780004628	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780004629	Walker A motif; other site
111780004630	ATP binding site [chemical binding]; other site
111780004631	Walker B motif; other site
111780004632	arginine finger; other site
111780004633	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780004634	Walker A motif; other site
111780004635	ATP binding site [chemical binding]; other site
111780004636	Walker B motif; other site
111780004637	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
111780004638	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
111780004639	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
111780004640	tandem repeat interface [polypeptide binding]; other site
111780004641	oligomer interface [polypeptide binding]; other site
111780004642	active site residues [active]
111780004643	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
111780004644	tandem repeat interface [polypeptide binding]; other site
111780004645	oligomer interface [polypeptide binding]; other site
111780004646	active site residues [active]
111780004647	Protein of unknown function, DUF479; Region: DUF479; cl01203
111780004648	hypothetical protein; Provisional; Region: PRK07236
111780004649	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
111780004650	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
111780004651	ABC1 family; Region: ABC1; pfam03109
111780004652	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
111780004653	active site
111780004654	ATP binding site [chemical binding]; other site
111780004655	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
111780004656	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
111780004657	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
111780004658	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780004659	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
111780004660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780004661	Coenzyme A binding pocket [chemical binding]; other site
111780004662	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
111780004663	classical (c) SDRs; Region: SDR_c; cd05233
111780004664	NAD(P) binding site [chemical binding]; other site
111780004665	active site
111780004666	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
111780004667	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
111780004668	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780004669	NIL domain; Region: NIL; pfam09383
111780004670	4Fe-4S binding domain; Region: Fer4; pfam00037
111780004671	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
111780004672	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
111780004673	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780004674	catalytic residues [active]
111780004675	short chain dehydrogenase; Provisional; Region: PRK06701
111780004676	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
111780004677	NAD binding site [chemical binding]; other site
111780004678	metal binding site [ion binding]; metal-binding site
111780004679	active site
111780004680	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780004681	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
111780004682	active site
111780004683	metal binding site [ion binding]; metal-binding site
111780004684	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
111780004685	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780004686	Response regulator receiver domain; Region: Response_reg; pfam00072
111780004687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004688	active site
111780004689	phosphorylation site [posttranslational modification]
111780004690	intermolecular recognition site; other site
111780004691	dimerization interface [polypeptide binding]; other site
111780004692	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780004693	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780004694	metal binding site [ion binding]; metal-binding site
111780004695	active site
111780004696	I-site; other site
111780004697	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
111780004698	TIGR02588 family protein; Region: TIGR02588
111780004699	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
111780004700	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
111780004701	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
111780004702	RNA binding surface [nucleotide binding]; other site
111780004703	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
111780004704	active site
111780004705	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
111780004706	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
111780004707	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
111780004708	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
111780004709	active site
111780004710	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780004711	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004712	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004713	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004714	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
111780004715	Domain of unknown function (DUF202); Region: DUF202; pfam02656
111780004716	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
111780004717	Cadmium resistance transporter; Region: Cad; pfam03596
111780004718	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
111780004719	Cadmium resistance transporter; Region: Cad; pfam03596
111780004720	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
111780004721	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
111780004722	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
111780004723	Walker A/P-loop; other site
111780004724	ATP binding site [chemical binding]; other site
111780004725	Q-loop/lid; other site
111780004726	ABC transporter signature motif; other site
111780004727	Walker B; other site
111780004728	D-loop; other site
111780004729	H-loop/switch region; other site
111780004730	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780004731	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
111780004732	putative switch regulator; other site
111780004733	non-specific DNA interactions [nucleotide binding]; other site
111780004734	DNA binding site [nucleotide binding]
111780004735	sequence specific DNA binding site [nucleotide binding]; other site
111780004736	putative cAMP binding site [chemical binding]; other site
111780004737	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
111780004738	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
111780004739	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
111780004740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780004741	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
111780004742	putative dimerization interface [polypeptide binding]; other site
111780004743	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
111780004744	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
111780004745	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
111780004746	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
111780004747	putative active site [active]
111780004748	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
111780004749	putative active site [active]
111780004750	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
111780004751	pseudouridine synthase; Region: TIGR00093
111780004752	active site
111780004753	Predicted GTPase [General function prediction only]; Region: COG3596
111780004754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780004755	YfjP GTPase; Region: YfjP; cd11383
111780004756	G1 box; other site
111780004757	Walker A/P-loop; other site
111780004758	GTP/Mg2+ binding site [chemical binding]; other site
111780004759	ATP binding site [chemical binding]; other site
111780004760	Switch I region; other site
111780004761	G2 box; other site
111780004762	Switch II region; other site
111780004763	G3 box; other site
111780004764	G4 box; other site
111780004765	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
111780004766	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
111780004767	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
111780004768	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
111780004769	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
111780004770	catalytic motif [active]
111780004771	Zn binding site [ion binding]; other site
111780004772	RibD C-terminal domain; Region: RibD_C; cl17279
111780004773	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
111780004774	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780004775	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780004776	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780004777	DNA binding residues [nucleotide binding]
111780004778	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
111780004779	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
111780004780	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
111780004781	active site
111780004782	substrate binding site [chemical binding]; other site
111780004783	metal binding site [ion binding]; metal-binding site
111780004784	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
111780004785	active site
111780004786	dimerization interface [polypeptide binding]; other site
111780004787	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
111780004788	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780004789	Predicted membrane protein [Function unknown]; Region: COG1808
111780004790	hypothetical protein; Provisional; Region: PRK06849
111780004791	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780004792	ATP-grasp domain; Region: ATP-grasp_4; cl17255
111780004793	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
111780004794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780004795	S-adenosylmethionine binding site [chemical binding]; other site
111780004796	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
111780004797	active site
111780004798	NAD binding site [chemical binding]; other site
111780004799	metal binding site [ion binding]; metal-binding site
111780004800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004801	PAS domain; Region: PAS_9; pfam13426
111780004802	putative active site [active]
111780004803	heme pocket [chemical binding]; other site
111780004804	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780004805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004806	active site
111780004807	phosphorylation site [posttranslational modification]
111780004808	intermolecular recognition site; other site
111780004809	hypothetical protein; Provisional; Region: PRK13560
111780004810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004811	putative active site [active]
111780004812	heme pocket [chemical binding]; other site
111780004813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004814	putative active site [active]
111780004815	heme pocket [chemical binding]; other site
111780004816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004817	putative active site [active]
111780004818	heme pocket [chemical binding]; other site
111780004819	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004820	putative active site [active]
111780004821	heme pocket [chemical binding]; other site
111780004822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780004823	dimer interface [polypeptide binding]; other site
111780004824	phosphorylation site [posttranslational modification]
111780004825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780004826	ATP binding site [chemical binding]; other site
111780004827	Mg2+ binding site [ion binding]; other site
111780004828	G-X-G motif; other site
111780004829	Response regulator receiver domain; Region: Response_reg; pfam00072
111780004830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004831	active site
111780004832	phosphorylation site [posttranslational modification]
111780004833	intermolecular recognition site; other site
111780004834	dimerization interface [polypeptide binding]; other site
111780004835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004836	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780004837	active site
111780004838	phosphorylation site [posttranslational modification]
111780004839	intermolecular recognition site; other site
111780004840	dimerization interface [polypeptide binding]; other site
111780004841	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
111780004842	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
111780004843	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
111780004844	ThiS interaction site; other site
111780004845	putative active site [active]
111780004846	tetramer interface [polypeptide binding]; other site
111780004847	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780004848	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780004849	active site
111780004850	ATP binding site [chemical binding]; other site
111780004851	substrate binding site [chemical binding]; other site
111780004852	activation loop (A-loop); other site
111780004853	GUN4-like; Region: GUN4; pfam05419
111780004854	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
111780004855	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
111780004856	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
111780004857	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
111780004858	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780004859	FeS/SAM binding site; other site
111780004860	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
111780004861	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
111780004862	HD domain; Region: HD_5; pfam13487
111780004863	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780004864	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004865	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780004866	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004867	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004868	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780004869	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
111780004870	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780004871	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780004872	ligand binding site [chemical binding]; other site
111780004873	flexible hinge region; other site
111780004874	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
111780004875	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
111780004876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780004877	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780004878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004879	active site
111780004880	phosphorylation site [posttranslational modification]
111780004881	intermolecular recognition site; other site
111780004882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780004883	DNA binding site [nucleotide binding]
111780004884	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
111780004885	Cache domain; Region: Cache_1; pfam02743
111780004886	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780004887	dimerization interface [polypeptide binding]; other site
111780004888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004889	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780004890	putative active site [active]
111780004891	heme pocket [chemical binding]; other site
111780004892	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004893	putative active site [active]
111780004894	heme pocket [chemical binding]; other site
111780004895	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780004896	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780004897	PAS domain S-box; Region: sensory_box; TIGR00229
111780004898	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780004899	putative active site [active]
111780004900	heme pocket [chemical binding]; other site
111780004901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780004902	dimer interface [polypeptide binding]; other site
111780004903	phosphorylation site [posttranslational modification]
111780004904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780004905	ATP binding site [chemical binding]; other site
111780004906	Mg2+ binding site [ion binding]; other site
111780004907	G-X-G motif; other site
111780004908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004909	active site
111780004910	phosphorylation site [posttranslational modification]
111780004911	intermolecular recognition site; other site
111780004912	dimerization interface [polypeptide binding]; other site
111780004913	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780004914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780004915	active site
111780004916	phosphorylation site [posttranslational modification]
111780004917	intermolecular recognition site; other site
111780004918	dimerization interface [polypeptide binding]; other site
111780004919	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
111780004920	arginine deiminase; Provisional; Region: PRK01388
111780004921	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
111780004922	proposed catalytic triad [active]
111780004923	active site nucleophile [active]
111780004924	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
111780004925	Predicted deacylase [General function prediction only]; Region: COG3608
111780004926	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
111780004927	active site
111780004928	Zn binding site [ion binding]; other site
111780004929	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
111780004930	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
111780004931	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780004932	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780004933	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
111780004934	protein binding site [polypeptide binding]; other site
111780004935	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
111780004936	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
111780004937	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
111780004938	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
111780004939	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
111780004940	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
111780004941	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
111780004942	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
111780004943	hinge; other site
111780004944	active site
111780004945	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
111780004946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780004947	Walker A/P-loop; other site
111780004948	ATP binding site [chemical binding]; other site
111780004949	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
111780004950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
111780004951	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
111780004952	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
111780004953	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
111780004954	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
111780004955	homodimer interface [polypeptide binding]; other site
111780004956	NADP binding site [chemical binding]; other site
111780004957	substrate binding site [chemical binding]; other site
111780004958	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
111780004959	nudix motif; other site
111780004960	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
111780004961	C-terminal peptidase (prc); Region: prc; TIGR00225
111780004962	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
111780004963	protein binding site [polypeptide binding]; other site
111780004964	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
111780004965	Catalytic dyad [active]
111780004966	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
111780004967	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
111780004968	metal binding site 2 [ion binding]; metal-binding site
111780004969	putative DNA binding helix; other site
111780004970	metal binding site 1 [ion binding]; metal-binding site
111780004971	dimer interface [polypeptide binding]; other site
111780004972	structural Zn2+ binding site [ion binding]; other site
111780004973	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
111780004974	substrate binding pocket [chemical binding]; other site
111780004975	substrate-Mg2+ binding site; other site
111780004976	aspartate-rich region 1; other site
111780004977	aspartate-rich region 2; other site
111780004978	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780004979	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780004980	catalytic loop [active]
111780004981	iron binding site [ion binding]; other site
111780004982	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780004983	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
111780004984	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
111780004985	putative active site [active]
111780004986	putative metal binding site [ion binding]; other site
111780004987	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
111780004988	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780004989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780004990	homodimer interface [polypeptide binding]; other site
111780004991	catalytic residue [active]
111780004992	ribonuclease PH; Reviewed; Region: rph; PRK00173
111780004993	Ribonuclease PH; Region: RNase_PH_bact; cd11362
111780004994	hexamer interface [polypeptide binding]; other site
111780004995	active site
111780004996	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
111780004997	Ycf35; Provisional; Region: ycf35; CHL00193
111780004998	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
111780004999	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
111780005000	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
111780005001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005002	PAS fold; Region: PAS_3; pfam08447
111780005003	putative active site [active]
111780005004	heme pocket [chemical binding]; other site
111780005005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005006	PAS fold; Region: PAS_3; pfam08447
111780005007	putative active site [active]
111780005008	heme pocket [chemical binding]; other site
111780005009	PAS fold; Region: PAS_4; pfam08448
111780005010	PAS fold; Region: PAS_4; pfam08448
111780005011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
111780005012	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005014	active site
111780005015	phosphorylation site [posttranslational modification]
111780005016	intermolecular recognition site; other site
111780005017	dimerization interface [polypeptide binding]; other site
111780005018	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780005019	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780005020	active site
111780005021	ATP binding site [chemical binding]; other site
111780005022	substrate binding site [chemical binding]; other site
111780005023	activation loop (A-loop); other site
111780005024	Predicted ATPase [General function prediction only]; Region: COG3899
111780005025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780005026	Walker A motif; other site
111780005027	ATP binding site [chemical binding]; other site
111780005028	Walker B motif; other site
111780005029	arginine finger; other site
111780005030	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780005031	GAF domain; Region: GAF; pfam01590
111780005032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005033	dimer interface [polypeptide binding]; other site
111780005034	phosphorylation site [posttranslational modification]
111780005035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005036	ATP binding site [chemical binding]; other site
111780005037	Mg2+ binding site [ion binding]; other site
111780005038	G-X-G motif; other site
111780005039	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780005040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005041	active site
111780005042	phosphorylation site [posttranslational modification]
111780005043	intermolecular recognition site; other site
111780005044	dimerization interface [polypeptide binding]; other site
111780005045	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005047	active site
111780005048	phosphorylation site [posttranslational modification]
111780005049	intermolecular recognition site; other site
111780005050	dimerization interface [polypeptide binding]; other site
111780005051	PAS domain S-box; Region: sensory_box; TIGR00229
111780005052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005053	putative active site [active]
111780005054	heme pocket [chemical binding]; other site
111780005055	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
111780005056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005057	putative active site [active]
111780005058	heme pocket [chemical binding]; other site
111780005059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005060	dimer interface [polypeptide binding]; other site
111780005061	phosphorylation site [posttranslational modification]
111780005062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005063	ATP binding site [chemical binding]; other site
111780005064	Mg2+ binding site [ion binding]; other site
111780005065	G-X-G motif; other site
111780005066	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005068	active site
111780005069	phosphorylation site [posttranslational modification]
111780005070	intermolecular recognition site; other site
111780005071	dimerization interface [polypeptide binding]; other site
111780005072	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
111780005073	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
111780005074	proline aminopeptidase P II; Provisional; Region: PRK10879
111780005075	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
111780005076	active site
111780005077	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
111780005078	active site
111780005079	catalytic triad [active]
111780005080	oxyanion hole [active]
111780005081	S-layer homology domain; Region: SLH; pfam00395
111780005082	Spherulation-specific family 4; Region: Spherulin4; pfam12138
111780005083	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
111780005084	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
111780005085	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780005086	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005088	active site
111780005089	phosphorylation site [posttranslational modification]
111780005090	intermolecular recognition site; other site
111780005091	dimerization interface [polypeptide binding]; other site
111780005092	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780005093	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
111780005094	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
111780005095	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
111780005096	Mg++ binding site [ion binding]; other site
111780005097	putative catalytic motif [active]
111780005098	putative substrate binding site [chemical binding]; other site
111780005099	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
111780005100	Uncharacterized conserved protein [Function unknown]; Region: COG1434
111780005101	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
111780005102	putative active site [active]
111780005103	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
111780005104	Transglycosylase; Region: Transgly; pfam00912
111780005105	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
111780005106	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
111780005107	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
111780005108	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
111780005109	molybdopterin cofactor binding site; other site
111780005110	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
111780005111	molybdopterin cofactor binding site; other site
111780005112	aspartate aminotransferase; Provisional; Region: PRK05764
111780005113	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780005114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780005115	homodimer interface [polypeptide binding]; other site
111780005116	catalytic residue [active]
111780005117	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
111780005118	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
111780005119	Walker A/P-loop; other site
111780005120	ATP binding site [chemical binding]; other site
111780005121	Q-loop/lid; other site
111780005122	ABC transporter signature motif; other site
111780005123	Walker B; other site
111780005124	D-loop; other site
111780005125	H-loop/switch region; other site
111780005126	TOBE domain; Region: TOBE_2; pfam08402
111780005127	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
111780005128	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
111780005129	active site
111780005130	homodimer interface [polypeptide binding]; other site
111780005131	catalytic site [active]
111780005132	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
111780005133	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
111780005134	dimerization interface [polypeptide binding]; other site
111780005135	putative DNA binding site [nucleotide binding]; other site
111780005136	putative Zn2+ binding site [ion binding]; other site
111780005137	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
111780005138	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
111780005139	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
111780005140	heme-binding site [chemical binding]; other site
111780005141	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780005142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780005143	S-adenosylmethionine binding site [chemical binding]; other site
111780005144	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
111780005145	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
111780005146	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780005147	YcfA-like protein; Region: YcfA; cl00752
111780005148	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
111780005149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780005150	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
111780005151	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
111780005152	active site
111780005153	ATP binding site [chemical binding]; other site
111780005154	substrate binding site [chemical binding]; other site
111780005155	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
111780005156	L10 interface [polypeptide binding]; other site
111780005157	core dimer interface [polypeptide binding]; other site
111780005158	L11 interface [polypeptide binding]; other site
111780005159	putative EF-Tu interaction site [polypeptide binding]; other site
111780005160	putative EF-G interaction site [polypeptide binding]; other site
111780005161	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
111780005162	23S rRNA interface [nucleotide binding]; other site
111780005163	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
111780005164	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
111780005165	mRNA/rRNA interface [nucleotide binding]; other site
111780005166	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
111780005167	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
111780005168	23S rRNA interface [nucleotide binding]; other site
111780005169	L7/L12 interface [polypeptide binding]; other site
111780005170	putative thiostrepton binding site; other site
111780005171	L25 interface [polypeptide binding]; other site
111780005172	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
111780005173	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
111780005174	putative homodimer interface [polypeptide binding]; other site
111780005175	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
111780005176	heterodimer interface [polypeptide binding]; other site
111780005177	homodimer interface [polypeptide binding]; other site
111780005178	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
111780005179	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
111780005180	NIMA-related protein kinase; Provisional; Region: PTZ00266
111780005181	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
111780005182	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
111780005183	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
111780005184	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
111780005185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
111780005186	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
111780005187	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
111780005188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780005189	S-adenosylmethionine binding site [chemical binding]; other site
111780005190	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
111780005191	Cytochrome P450; Region: p450; cl12078
111780005192	AAA domain; Region: AAA_33; pfam13671
111780005193	AAA domain; Region: AAA_17; pfam13207
111780005194	pyrroline-5-carboxylate reductase; Region: PLN02688
111780005195	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
111780005196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
111780005197	Uncharacterized conserved protein [Function unknown]; Region: COG0432
111780005198	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
111780005199	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
111780005200	Walker A/P-loop; other site
111780005201	ATP binding site [chemical binding]; other site
111780005202	Q-loop/lid; other site
111780005203	ABC transporter signature motif; other site
111780005204	Walker B; other site
111780005205	D-loop; other site
111780005206	H-loop/switch region; other site
111780005207	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
111780005208	active site
111780005209	catalytic triad [active]
111780005210	ATP synthase A chain; Region: ATP-synt_A; cl00413
111780005211	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
111780005212	Catalytic site [active]
111780005213	Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609
111780005214	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
111780005215	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
111780005216	hinge; other site
111780005217	active site
111780005218	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
111780005219	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
111780005220	Tetramer interface [polypeptide binding]; other site
111780005221	active site
111780005222	FMN-binding site [chemical binding]; other site
111780005223	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
111780005224	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
111780005225	putative catalytic cysteine [active]
111780005226	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
111780005227	homooctamer interface [polypeptide binding]; other site
111780005228	active site
111780005229	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
111780005230	pentamer interface [polypeptide binding]; other site
111780005231	dodecaamer interface [polypeptide binding]; other site
111780005232	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
111780005233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780005234	Walker A motif; other site
111780005235	ATP binding site [chemical binding]; other site
111780005236	Walker B motif; other site
111780005237	arginine finger; other site
111780005238	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
111780005239	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780005240	active site
111780005241	NTP binding site [chemical binding]; other site
111780005242	metal binding triad [ion binding]; metal-binding site
111780005243	antibiotic binding site [chemical binding]; other site
111780005244	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780005245	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005246	dimer interface [polypeptide binding]; other site
111780005247	phosphorylation site [posttranslational modification]
111780005248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005249	ATP binding site [chemical binding]; other site
111780005250	Mg2+ binding site [ion binding]; other site
111780005251	G-X-G motif; other site
111780005252	short chain dehydrogenase; Provisional; Region: PRK06123
111780005253	classical (c) SDRs; Region: SDR_c; cd05233
111780005254	NAD(P) binding site [chemical binding]; other site
111780005255	active site
111780005256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780005257	Coenzyme A binding pocket [chemical binding]; other site
111780005258	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
111780005259	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
111780005260	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
111780005261	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
111780005262	putative catalytic site [active]
111780005263	putative phosphate binding site [ion binding]; other site
111780005264	active site
111780005265	metal binding site A [ion binding]; metal-binding site
111780005266	DNA binding site [nucleotide binding]
111780005267	putative AP binding site [nucleotide binding]; other site
111780005268	putative metal binding site B [ion binding]; other site
111780005269	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
111780005270	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
111780005271	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
111780005272	ring oligomerisation interface [polypeptide binding]; other site
111780005273	ATP/Mg binding site [chemical binding]; other site
111780005274	stacking interactions; other site
111780005275	hinge regions; other site
111780005276	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
111780005277	oligomerisation interface [polypeptide binding]; other site
111780005278	mobile loop; other site
111780005279	roof hairpin; other site
111780005280	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
111780005281	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
111780005282	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
111780005283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780005284	Walker A motif; other site
111780005285	ATP binding site [chemical binding]; other site
111780005286	Walker B motif; other site
111780005287	arginine finger; other site
111780005288	Peptidase family M41; Region: Peptidase_M41; pfam01434
111780005289	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
111780005290	homotrimer interaction site [polypeptide binding]; other site
111780005291	putative active site [active]
111780005292	PemK-like protein; Region: PemK; pfam02452
111780005293	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780005294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780005295	binding surface
111780005296	TPR motif; other site
111780005297	CHAT domain; Region: CHAT; cl17868
111780005298	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
111780005299	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
111780005300	Surface antigen; Region: Bac_surface_Ag; pfam01103
111780005301	glycogen branching enzyme; Provisional; Region: PRK05402
111780005302	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
111780005303	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
111780005304	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
111780005305	active site
111780005306	catalytic site [active]
111780005307	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
111780005308	Chromate transporter; Region: Chromate_transp; pfam02417
111780005309	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
111780005310	Chromate transporter; Region: Chromate_transp; pfam02417
111780005311	AAA ATPase domain; Region: AAA_16; pfam13191
111780005312	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780005313	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780005314	structural tetrad; other site
111780005315	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780005316	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780005317	structural tetrad; other site
111780005318	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
111780005319	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
111780005320	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780005321	active site
111780005322	motif I; other site
111780005323	motif II; other site
111780005324	ferrochelatase; Reviewed; Region: hemH; PRK00035
111780005325	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
111780005326	active site
111780005327	C-terminal domain interface [polypeptide binding]; other site
111780005328	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
111780005329	active site
111780005330	N-terminal domain interface [polypeptide binding]; other site
111780005331	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
111780005332	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
111780005333	GSH binding site [chemical binding]; other site
111780005334	catalytic residues [active]
111780005335	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
111780005336	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
111780005337	active site
111780005338	dimer interface [polypeptide binding]; other site
111780005339	AIR carboxylase; Region: AIRC; pfam00731
111780005340	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780005341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780005342	binding surface
111780005343	TPR motif; other site
111780005344	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780005345	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780005346	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
111780005347	MviN-like protein; Region: MVIN; pfam03023
111780005348	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
111780005349	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
111780005350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780005351	motif II; other site
111780005352	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
111780005353	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780005354	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780005355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780005356	Walker A/P-loop; other site
111780005357	ATP binding site [chemical binding]; other site
111780005358	Q-loop/lid; other site
111780005359	ABC transporter signature motif; other site
111780005360	Walker B; other site
111780005361	D-loop; other site
111780005362	H-loop/switch region; other site
111780005363	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780005364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780005365	non-specific DNA binding site [nucleotide binding]; other site
111780005366	salt bridge; other site
111780005367	sequence-specific DNA binding site [nucleotide binding]; other site
111780005368	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
111780005369	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
111780005370	HIGH motif; other site
111780005371	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
111780005372	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
111780005373	active site
111780005374	KMSKS motif; other site
111780005375	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
111780005376	tRNA binding surface [nucleotide binding]; other site
111780005377	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
111780005378	homoserine kinase; Provisional; Region: PRK01212
111780005379	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
111780005380	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
111780005381	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
111780005382	putative active site [active]
111780005383	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
111780005384	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
111780005385	tRNA; other site
111780005386	putative tRNA binding site [nucleotide binding]; other site
111780005387	putative NADP binding site [chemical binding]; other site
111780005388	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
111780005389	aspartate aminotransferase; Provisional; Region: PRK05957
111780005390	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780005391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780005392	homodimer interface [polypeptide binding]; other site
111780005393	catalytic residue [active]
111780005394	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
111780005395	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
111780005396	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
111780005397	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
111780005398	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
111780005399	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
111780005400	dimerization interface [polypeptide binding]; other site
111780005401	active site
111780005402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780005403	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780005404	Probable transposase; Region: OrfB_IS605; pfam01385
111780005405	haemagglutination activity domain; Region: Haemagg_act; pfam05860
111780005406	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
111780005407	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
111780005408	dimer interface [polypeptide binding]; other site
111780005409	ADP-ribose binding site [chemical binding]; other site
111780005410	active site
111780005411	nudix motif; other site
111780005412	metal binding site [ion binding]; metal-binding site
111780005413	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
111780005414	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780005415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780005416	homodimer interface [polypeptide binding]; other site
111780005417	catalytic residue [active]
111780005418	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
111780005419	RimM N-terminal domain; Region: RimM; pfam01782
111780005420	PRC-barrel domain; Region: PRC; pfam05239
111780005421	ABC-2 type transporter; Region: ABC2_membrane; cl17235
111780005422	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
111780005423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780005424	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
111780005425	Walker A/P-loop; other site
111780005426	ATP binding site [chemical binding]; other site
111780005427	Q-loop/lid; other site
111780005428	ABC transporter signature motif; other site
111780005429	Walker B; other site
111780005430	D-loop; other site
111780005431	H-loop/switch region; other site
111780005432	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
111780005433	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780005434	active site
111780005435	ATP binding site [chemical binding]; other site
111780005436	substrate binding site [chemical binding]; other site
111780005437	activation loop (A-loop); other site
111780005438	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
111780005439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780005440	NAD(P) binding site [chemical binding]; other site
111780005441	active site
111780005442	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
111780005443	substrate binding site [chemical binding]; other site
111780005444	active site
111780005445	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
111780005446	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780005447	active site
111780005448	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
111780005449	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
111780005450	homotetramer interface [polypeptide binding]; other site
111780005451	FMN binding site [chemical binding]; other site
111780005452	homodimer contacts [polypeptide binding]; other site
111780005453	putative active site [active]
111780005454	putative substrate binding site [chemical binding]; other site
111780005455	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
111780005456	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780005457	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780005458	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
111780005459	O-Antigen ligase; Region: Wzy_C; pfam04932
111780005460	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780005461	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
111780005462	putative ADP-binding pocket [chemical binding]; other site
111780005463	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780005464	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780005465	active site
111780005466	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
111780005467	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
111780005468	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780005469	Chain length determinant protein; Region: Wzz; pfam02706
111780005470	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
111780005471	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780005472	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780005473	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780005474	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780005475	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
111780005476	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
111780005477	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
111780005478	thiamine phosphate binding site [chemical binding]; other site
111780005479	active site
111780005480	pyrophosphate binding site [ion binding]; other site
111780005481	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
111780005482	thiS-thiF/thiG interaction site; other site
111780005483	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
111780005484	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
111780005485	homotrimer interface [polypeptide binding]; other site
111780005486	Walker A motif; other site
111780005487	GTP binding site [chemical binding]; other site
111780005488	Walker B motif; other site
111780005489	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
111780005490	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780005491	putative metal binding site; other site
111780005492	putative acyl transferase; Provisional; Region: PRK10502
111780005493	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
111780005494	putative trimer interface [polypeptide binding]; other site
111780005495	putative active site [active]
111780005496	putative substrate binding site [chemical binding]; other site
111780005497	putative CoA binding site [chemical binding]; other site
111780005498	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
111780005499	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
111780005500	glycogen binding site [chemical binding]; other site
111780005501	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
111780005502	active site
111780005503	catalytic site [active]
111780005504	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
111780005505	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780005506	EamA-like transporter family; Region: EamA; pfam00892
111780005507	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780005508	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780005509	DNA binding residues [nucleotide binding]
111780005510	dimerization interface [polypeptide binding]; other site
111780005511	MAPEG family; Region: MAPEG; cl09190
111780005512	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
111780005513	MutS domain I; Region: MutS_I; pfam01624
111780005514	MutS domain II; Region: MutS_II; pfam05188
111780005515	MutS domain III; Region: MutS_III; pfam05192
111780005516	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
111780005517	Walker A/P-loop; other site
111780005518	ATP binding site [chemical binding]; other site
111780005519	Q-loop/lid; other site
111780005520	ABC transporter signature motif; other site
111780005521	Walker B; other site
111780005522	D-loop; other site
111780005523	H-loop/switch region; other site
111780005524	classical (c) SDRs; Region: SDR_c; cd05233
111780005525	NAD(P) binding site [chemical binding]; other site
111780005526	active site
111780005527	Predicted metal-binding protein [General function prediction only]; Region: COG3019
111780005528	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
111780005529	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780005530	Multicopper oxidase; Region: Cu-oxidase; pfam00394
111780005531	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780005532	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
111780005533	high affinity sulphate transporter 1; Region: sulP; TIGR00815
111780005534	Sulfate transporter family; Region: Sulfate_transp; pfam00916
111780005535	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
111780005536	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
111780005537	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
111780005538	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780005539	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
111780005540	active site clefts [active]
111780005541	zinc binding site [ion binding]; other site
111780005542	dimer interface [polypeptide binding]; other site
111780005543	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
111780005544	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780005545	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
111780005546	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
111780005547	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
111780005548	Fasciclin domain; Region: Fasciclin; pfam02469
111780005549	proton extrusion protein PcxA; Provisional; Region: PRK02507
111780005550	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
111780005551	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
111780005552	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
111780005553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780005554	binding surface
111780005555	TPR repeat; Region: TPR_11; pfam13414
111780005556	TPR motif; other site
111780005557	TPR repeat; Region: TPR_11; pfam13414
111780005558	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
111780005559	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780005560	substrate binding pocket [chemical binding]; other site
111780005561	membrane-bound complex binding site; other site
111780005562	hinge residues; other site
111780005563	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
111780005564	23S rRNA binding site [nucleotide binding]; other site
111780005565	L21 binding site [polypeptide binding]; other site
111780005566	L13 binding site [polypeptide binding]; other site
111780005567	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
111780005568	cell division protein; Validated; Region: ftsH; CHL00176
111780005569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780005570	Walker A motif; other site
111780005571	ATP binding site [chemical binding]; other site
111780005572	Walker B motif; other site
111780005573	arginine finger; other site
111780005574	Peptidase family M41; Region: Peptidase_M41; pfam01434
111780005575	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
111780005576	S-layer homology domain; Region: SLH; pfam00395
111780005577	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780005578	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
111780005579	Double zinc ribbon; Region: DZR; pfam12773
111780005580	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780005581	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005582	dimer interface [polypeptide binding]; other site
111780005583	phosphorylation site [posttranslational modification]
111780005584	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
111780005585	L-aspartate oxidase; Provisional; Region: PRK06175
111780005586	L-aspartate oxidase; Provisional; Region: PRK07395
111780005587	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
111780005588	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780005589	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780005590	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
111780005591	trimer interface [polypeptide binding]; other site
111780005592	active site
111780005593	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
111780005594	putative hydrophobic ligand binding site [chemical binding]; other site
111780005595	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
111780005596	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
111780005597	active site
111780005598	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
111780005599	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
111780005600	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780005601	ATP binding site [chemical binding]; other site
111780005602	putative Mg++ binding site [ion binding]; other site
111780005603	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780005604	nucleotide binding region [chemical binding]; other site
111780005605	ATP-binding site [chemical binding]; other site
111780005606	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
111780005607	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
111780005608	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
111780005609	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780005610	active site
111780005611	catalytic tetrad [active]
111780005612	Bifunctional nuclease; Region: DNase-RNase; pfam02577
111780005613	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
111780005614	Lumazine binding domain; Region: Lum_binding; pfam00677
111780005615	Lumazine binding domain; Region: Lum_binding; pfam00677
111780005616	Late competence development protein ComFB; Region: ComFB; pfam10719
111780005617	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
111780005618	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
111780005619	active site
111780005620	glycogen synthase; Provisional; Region: glgA; PRK00654
111780005621	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
111780005622	ADP-binding pocket [chemical binding]; other site
111780005623	homodimer interface [polypeptide binding]; other site
111780005624	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
111780005625	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
111780005626	hexamer interface [polypeptide binding]; other site
111780005627	ligand binding site [chemical binding]; other site
111780005628	putative active site [active]
111780005629	NAD(P) binding site [chemical binding]; other site
111780005630	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780005631	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780005632	Probable transposase; Region: OrfB_IS605; pfam01385
111780005633	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780005634	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
111780005635	Domain of unknown function DUF21; Region: DUF21; pfam01595
111780005636	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
111780005637	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
111780005638	phosphoenolpyruvate synthase; Validated; Region: PRK06241
111780005639	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
111780005640	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
111780005641	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
111780005642	Repair protein; Region: Repair_PSII; pfam04536
111780005643	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780005644	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
111780005645	catalytic site [active]
111780005646	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
111780005647	homotrimer interaction site [polypeptide binding]; other site
111780005648	zinc binding site [ion binding]; other site
111780005649	CDP-binding sites; other site
111780005650	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
111780005651	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
111780005652	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780005653	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780005654	ligand binding site [chemical binding]; other site
111780005655	flexible hinge region; other site
111780005656	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
111780005657	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
111780005658	putative active site [active]
111780005659	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780005660	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780005661	Walker A/P-loop; other site
111780005662	ATP binding site [chemical binding]; other site
111780005663	Q-loop/lid; other site
111780005664	ABC transporter signature motif; other site
111780005665	Walker B; other site
111780005666	D-loop; other site
111780005667	H-loop/switch region; other site
111780005668	S-formylglutathione hydrolase; Region: PLN02442
111780005669	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
111780005670	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
111780005671	glutamine synthetase, type I; Region: GlnA; TIGR00653
111780005672	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
111780005673	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
111780005674	allophycocyanin, beta subunit; Region: apcB; TIGR01337
111780005675	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
111780005676	protein I interface; other site
111780005677	D2 interface; other site
111780005678	protein T interface; other site
111780005679	chlorophyll binding site; other site
111780005680	beta carotene binding site; other site
111780005681	pheophytin binding site; other site
111780005682	manganese-stabilizing polypeptide interface; other site
111780005683	CP43 interface; other site
111780005684	protein L interface; other site
111780005685	oxygen evolving complex binding site; other site
111780005686	bromide binding site; other site
111780005687	quinone binding site; other site
111780005688	Fe binding site [ion binding]; other site
111780005689	core light harvesting interface; other site
111780005690	cytochrome b559 alpha subunit interface; other site
111780005691	cytochrome c-550 interface; other site
111780005692	protein J interface; other site
111780005693	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
111780005694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780005695	FeS/SAM binding site; other site
111780005696	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
111780005697	active site
111780005698	catalytic residues [active]
111780005699	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
111780005700	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
111780005701	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
111780005702	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
111780005703	active site
111780005704	dimer interface [polypeptide binding]; other site
111780005705	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
111780005706	dimer interface [polypeptide binding]; other site
111780005707	active site
111780005708	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
111780005709	Dihaem cytochrome c; Region: DHC; pfam09626
111780005710	Putative transcription activator [Transcription]; Region: TenA; COG0819
111780005711	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
111780005712	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
111780005713	substrate binding site [chemical binding]; other site
111780005714	dimer interface [polypeptide binding]; other site
111780005715	ATP binding site [chemical binding]; other site
111780005716	quinolinate synthetase; Provisional; Region: PRK09375
111780005717	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
111780005718	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
111780005719	dimer interface [polypeptide binding]; other site
111780005720	substrate binding site [chemical binding]; other site
111780005721	metal binding sites [ion binding]; metal-binding site
111780005722	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
111780005723	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
111780005724	RNA binding site [nucleotide binding]; other site
111780005725	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
111780005726	RNA binding site [nucleotide binding]; other site
111780005727	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
111780005728	RNA binding site [nucleotide binding]; other site
111780005729	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
111780005730	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
111780005731	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
111780005732	SNF2 Helicase protein; Region: DUF3670; pfam12419
111780005733	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780005734	ATP binding site [chemical binding]; other site
111780005735	putative Mg++ binding site [ion binding]; other site
111780005736	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780005737	nucleotide binding region [chemical binding]; other site
111780005738	ATP-binding site [chemical binding]; other site
111780005739	ribonuclease E; Reviewed; Region: rne; PRK10811
111780005740	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
111780005741	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
111780005742	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
111780005743	ATP-grasp domain; Region: ATP-grasp; pfam02222
111780005744	YCII-related domain; Region: YCII; cl00999
111780005745	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
111780005746	Nitrogen regulatory protein P-II; Region: P-II; smart00938
111780005747	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
111780005748	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
111780005749	substrate binding site [chemical binding]; other site
111780005750	ligand binding site [chemical binding]; other site
111780005751	Domain of unknown function (DUF897); Region: DUF897; pfam05982
111780005752	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
111780005753	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
111780005754	active site clefts [active]
111780005755	zinc binding site [ion binding]; other site
111780005756	dimer interface [polypeptide binding]; other site
111780005757	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
111780005758	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
111780005759	RNase E interface [polypeptide binding]; other site
111780005760	trimer interface [polypeptide binding]; other site
111780005761	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
111780005762	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
111780005763	RNase E interface [polypeptide binding]; other site
111780005764	trimer interface [polypeptide binding]; other site
111780005765	active site
111780005766	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
111780005767	putative nucleic acid binding region [nucleotide binding]; other site
111780005768	G-X-X-G motif; other site
111780005769	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
111780005770	RNA binding site [nucleotide binding]; other site
111780005771	domain interface; other site
111780005772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005773	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005774	active site
111780005775	phosphorylation site [posttranslational modification]
111780005776	intermolecular recognition site; other site
111780005777	dimerization interface [polypeptide binding]; other site
111780005778	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005779	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780005780	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005781	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005782	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780005783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005784	active site
111780005785	phosphorylation site [posttranslational modification]
111780005786	intermolecular recognition site; other site
111780005787	dimerization interface [polypeptide binding]; other site
111780005788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780005789	DNA binding site [nucleotide binding]
111780005790	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780005791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005792	active site
111780005793	phosphorylation site [posttranslational modification]
111780005794	intermolecular recognition site; other site
111780005795	dimerization interface [polypeptide binding]; other site
111780005796	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780005797	GAF domain; Region: GAF; pfam01590
111780005798	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780005799	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780005800	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780005801	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780005802	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780005803	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780005804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005805	dimer interface [polypeptide binding]; other site
111780005806	phosphorylation site [posttranslational modification]
111780005807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005808	ATP binding site [chemical binding]; other site
111780005809	Mg2+ binding site [ion binding]; other site
111780005810	G-X-G motif; other site
111780005811	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
111780005812	Septum formation initiator; Region: DivIC; cl17659
111780005813	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
111780005814	seryl-tRNA synthetase; Provisional; Region: PRK05431
111780005815	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
111780005816	dimer interface [polypeptide binding]; other site
111780005817	active site
111780005818	motif 1; other site
111780005819	motif 2; other site
111780005820	motif 3; other site
111780005821	TROVE domain; Region: TROVE; pfam05731
111780005822	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
111780005823	trimer interface [polypeptide binding]; other site
111780005824	dimer interface [polypeptide binding]; other site
111780005825	putative active site [active]
111780005826	2TM domain; Region: 2TM; pfam13239
111780005827	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
111780005828	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
111780005829	dimer interface [polypeptide binding]; other site
111780005830	[2Fe-2S] cluster binding site [ion binding]; other site
111780005831	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780005832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005833	putative active site [active]
111780005834	heme pocket [chemical binding]; other site
111780005835	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005836	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780005837	putative active site [active]
111780005838	heme pocket [chemical binding]; other site
111780005839	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
111780005840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780005841	putative active site [active]
111780005842	heme pocket [chemical binding]; other site
111780005843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005844	dimer interface [polypeptide binding]; other site
111780005845	phosphorylation site [posttranslational modification]
111780005846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005847	ATP binding site [chemical binding]; other site
111780005848	Mg2+ binding site [ion binding]; other site
111780005849	G-X-G motif; other site
111780005850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005851	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005852	active site
111780005853	phosphorylation site [posttranslational modification]
111780005854	intermolecular recognition site; other site
111780005855	dimerization interface [polypeptide binding]; other site
111780005856	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
111780005857	tetramer interface [polypeptide binding]; other site
111780005858	dimer interface [polypeptide binding]; other site
111780005859	circadian clock protein KaiC; Reviewed; Region: PRK09302
111780005860	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780005861	Walker A motif; other site
111780005862	ATP binding site [chemical binding]; other site
111780005863	Walker B motif; other site
111780005864	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780005865	Walker A motif; other site
111780005866	Walker A motif; other site
111780005867	ATP binding site [chemical binding]; other site
111780005868	Walker B motif; other site
111780005869	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780005870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005871	active site
111780005872	phosphorylation site [posttranslational modification]
111780005873	intermolecular recognition site; other site
111780005874	dimerization interface [polypeptide binding]; other site
111780005875	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780005876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780005877	dimer interface [polypeptide binding]; other site
111780005878	phosphorylation site [posttranslational modification]
111780005879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005880	ATP binding site [chemical binding]; other site
111780005881	Mg2+ binding site [ion binding]; other site
111780005882	G-X-G motif; other site
111780005883	Response regulator receiver domain; Region: Response_reg; pfam00072
111780005884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005885	active site
111780005886	phosphorylation site [posttranslational modification]
111780005887	intermolecular recognition site; other site
111780005888	dimerization interface [polypeptide binding]; other site
111780005889	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780005890	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780005891	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
111780005892	protein binding site [polypeptide binding]; other site
111780005893	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
111780005894	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
111780005895	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
111780005896	active site
111780005897	homotetramer interface [polypeptide binding]; other site
111780005898	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
111780005899	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
111780005900	DinB family; Region: DinB; cl17821
111780005901	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780005902	active site
111780005903	ATP binding site [chemical binding]; other site
111780005904	substrate binding site [chemical binding]; other site
111780005905	activation loop (A-loop); other site
111780005906	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
111780005907	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780005908	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780005909	active site
111780005910	ATP binding site [chemical binding]; other site
111780005911	substrate binding site [chemical binding]; other site
111780005912	activation loop (A-loop); other site
111780005913	Right handed beta helix region; Region: Beta_helix; pfam13229
111780005914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
111780005915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780005916	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780005917	Probable transposase; Region: OrfB_IS605; pfam01385
111780005918	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780005919	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
111780005920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780005921	Mg2+ binding site [ion binding]; other site
111780005922	G-X-G motif; other site
111780005923	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
111780005924	anchoring element; other site
111780005925	dimer interface [polypeptide binding]; other site
111780005926	ATP binding site [chemical binding]; other site
111780005927	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
111780005928	active site
111780005929	putative metal-binding site [ion binding]; other site
111780005930	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
111780005931	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
111780005932	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
111780005933	DNA polymerase III subunit delta; Validated; Region: PRK07452
111780005934	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
111780005935	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780005936	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
111780005937	putative metal binding site; other site
111780005938	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780005939	hypothetical protein; Provisional; Region: PRK07394
111780005940	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
111780005941	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
111780005942	Transcriptional regulator [Transcription]; Region: LysR; COG0583
111780005943	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780005944	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
111780005945	dimerization interface [polypeptide binding]; other site
111780005946	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
111780005947	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
111780005948	active site
111780005949	homodimer interface [polypeptide binding]; other site
111780005950	catalytic site [active]
111780005951	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
111780005952	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
111780005953	metal ion-dependent adhesion site (MIDAS); other site
111780005954	YcfA-like protein; Region: YcfA; cl00752
111780005955	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
111780005956	hypothetical protein; Validated; Region: PRK07411
111780005957	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
111780005958	ATP binding site [chemical binding]; other site
111780005959	substrate interface [chemical binding]; other site
111780005960	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
111780005961	active site residue [active]
111780005962	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005963	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780005964	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005965	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005966	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780005967	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780005968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780005969	active site
111780005970	phosphorylation site [posttranslational modification]
111780005971	intermolecular recognition site; other site
111780005972	dimerization interface [polypeptide binding]; other site
111780005973	PAS fold; Region: PAS_4; pfam08448
111780005974	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780005975	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780005976	metal binding site [ion binding]; metal-binding site
111780005977	active site
111780005978	I-site; other site
111780005979	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780005980	TrkA-N domain; Region: TrkA_N; pfam02254
111780005981	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
111780005982	TrkA-N domain; Region: TrkA_N; pfam02254
111780005983	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
111780005984	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
111780005985	light-harvesting-like protein 3; Provisional; Region: PLN00014
111780005986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780005987	binding surface
111780005988	TPR motif; other site
111780005989	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
111780005990	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
111780005991	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780005992	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780005993	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
111780005994	substrate binding site; other site
111780005995	dimer interface; other site
111780005996	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
111780005997	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
111780005998	substrate binding site [chemical binding]; other site
111780005999	active site
111780006000	catalytic residues [active]
111780006001	heterodimer interface [polypeptide binding]; other site
111780006002	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
111780006003	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
111780006004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780006005	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780006006	Probable transposase; Region: OrfB_IS605; pfam01385
111780006007	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780006008	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
111780006009	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
111780006010	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
111780006011	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
111780006012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780006013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780006014	dimer interface [polypeptide binding]; other site
111780006015	phosphorylation site [posttranslational modification]
111780006016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780006017	ATP binding site [chemical binding]; other site
111780006018	Mg2+ binding site [ion binding]; other site
111780006019	G-X-G motif; other site
111780006020	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780006021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006022	active site
111780006023	phosphorylation site [posttranslational modification]
111780006024	intermolecular recognition site; other site
111780006025	dimerization interface [polypeptide binding]; other site
111780006026	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
111780006027	glutathione reductase; Validated; Region: PRK06116
111780006028	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780006029	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
111780006030	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
111780006031	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
111780006032	dimerization interface [polypeptide binding]; other site
111780006033	DPS ferroxidase diiron center [ion binding]; other site
111780006034	ion pore; other site
111780006035	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
111780006036	catalytic triad [active]
111780006037	dimer interface [polypeptide binding]; other site
111780006038	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780006039	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780006040	active site
111780006041	ATP binding site [chemical binding]; other site
111780006042	substrate binding site [chemical binding]; other site
111780006043	activation loop (A-loop); other site
111780006044	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
111780006045	active site
111780006046	catalytic triad [active]
111780006047	oxyanion hole [active]
111780006048	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
111780006049	active site
111780006050	catalytic site [active]
111780006051	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
111780006052	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
111780006053	GTP/Mg2+ binding site [chemical binding]; other site
111780006054	G4 box; other site
111780006055	G5 box; other site
111780006056	G1 box; other site
111780006057	Switch I region; other site
111780006058	G2 box; other site
111780006059	G3 box; other site
111780006060	Switch II region; other site
111780006061	Predicted deacylase [General function prediction only]; Region: COG3608
111780006062	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
111780006063	putative active site [active]
111780006064	Zn binding site [ion binding]; other site
111780006065	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
111780006066	RimK-like ATP-grasp domain; Region: RimK; pfam08443
111780006067	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
111780006068	putative hydrolase; Provisional; Region: PRK11460
111780006069	Predicted esterase [General function prediction only]; Region: COG0400
111780006070	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
111780006071	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
111780006072	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
111780006073	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780006074	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
111780006075	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780006076	motif II; other site
111780006077	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
111780006078	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
111780006079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780006080	dimer interface [polypeptide binding]; other site
111780006081	conserved gate region; other site
111780006082	putative PBP binding loops; other site
111780006083	ABC-ATPase subunit interface; other site
111780006084	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
111780006085	NMT1-like family; Region: NMT1_2; pfam13379
111780006086	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
111780006087	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
111780006088	Walker A/P-loop; other site
111780006089	ATP binding site [chemical binding]; other site
111780006090	Q-loop/lid; other site
111780006091	ABC transporter signature motif; other site
111780006092	Walker B; other site
111780006093	D-loop; other site
111780006094	H-loop/switch region; other site
111780006095	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
111780006096	Clp protease; Region: CLP_protease; pfam00574
111780006097	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
111780006098	oligomer interface [polypeptide binding]; other site
111780006099	active site residues [active]
111780006100	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
111780006101	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
111780006102	catalytic site [active]
111780006103	G-X2-G-X-G-K; other site
111780006104	hypothetical protein; Provisional; Region: PRK04323
111780006105	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
111780006106	Domain of unknown function (DUF814); Region: DUF814; pfam05670
111780006107	putative phosphoketolase; Provisional; Region: PRK05261
111780006108	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
111780006109	TPP-binding site; other site
111780006110	XFP C-terminal domain; Region: XFP_C; pfam09363
111780006111	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
111780006112	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
111780006113	putative ligand binding site [chemical binding]; other site
111780006114	putative NAD binding site [chemical binding]; other site
111780006115	catalytic site [active]
111780006116	Response regulator receiver domain; Region: Response_reg; pfam00072
111780006117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006118	active site
111780006119	phosphorylation site [posttranslational modification]
111780006120	intermolecular recognition site; other site
111780006121	dimerization interface [polypeptide binding]; other site
111780006122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
111780006123	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
111780006124	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780006125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
111780006126	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
111780006127	Protein of unknown function, DUF399; Region: DUF399; pfam04187
111780006128	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
111780006129	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
111780006130	putative active site [active]
111780006131	catalytic triad [active]
111780006132	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
111780006133	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
111780006134	Response regulator receiver domain; Region: Response_reg; pfam00072
111780006135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006136	active site
111780006137	phosphorylation site [posttranslational modification]
111780006138	intermolecular recognition site; other site
111780006139	dimerization interface [polypeptide binding]; other site
111780006140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780006141	PAS fold; Region: PAS_3; pfam08447
111780006142	putative active site [active]
111780006143	heme pocket [chemical binding]; other site
111780006144	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780006145	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780006146	metal binding site [ion binding]; metal-binding site
111780006147	active site
111780006148	I-site; other site
111780006149	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780006150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780006151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780006152	dimer interface [polypeptide binding]; other site
111780006153	phosphorylation site [posttranslational modification]
111780006154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780006155	ATP binding site [chemical binding]; other site
111780006156	G-X-G motif; other site
111780006157	Response regulator receiver domain; Region: Response_reg; pfam00072
111780006158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006159	active site
111780006160	phosphorylation site [posttranslational modification]
111780006161	dimerization interface [polypeptide binding]; other site
111780006162	circadian clock protein KaiC; Reviewed; Region: PRK09302
111780006163	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780006164	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780006165	Walker A motif; other site
111780006166	Walker A motif; other site
111780006167	ATP binding site [chemical binding]; other site
111780006168	Walker B motif; other site
111780006169	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
111780006170	Walker A motif; other site
111780006171	ATP binding site [chemical binding]; other site
111780006172	Walker B motif; other site
111780006173	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
111780006174	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
111780006175	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
111780006176	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
111780006177	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
111780006178	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
111780006179	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
111780006180	dimerization interface [polypeptide binding]; other site
111780006181	domain crossover interface; other site
111780006182	redox-dependent activation switch; other site
111780006183	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
111780006184	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
111780006185	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780006186	DNA binding residues [nucleotide binding]
111780006187	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
111780006188	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
111780006189	active site residue [active]
111780006190	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780006191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006192	active site
111780006193	phosphorylation site [posttranslational modification]
111780006194	intermolecular recognition site; other site
111780006195	dimerization interface [polypeptide binding]; other site
111780006196	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780006197	DNA binding site [nucleotide binding]
111780006198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780006199	dimer interface [polypeptide binding]; other site
111780006200	phosphorylation site [posttranslational modification]
111780006201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780006202	ATP binding site [chemical binding]; other site
111780006203	Mg2+ binding site [ion binding]; other site
111780006204	G-X-G motif; other site
111780006205	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780006206	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780006207	active site
111780006208	catalytic tetrad [active]
111780006209	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
111780006210	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
111780006211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780006212	Probable transposase; Region: OrfB_IS605; pfam01385
111780006213	haemagglutination activity domain; Region: Haemagg_act; pfam05860
111780006214	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
111780006215	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
111780006216	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780006217	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780006218	active site
111780006219	ATP binding site [chemical binding]; other site
111780006220	substrate binding site [chemical binding]; other site
111780006221	activation loop (A-loop); other site
111780006222	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
111780006223	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780006224	catalytic triad [active]
111780006225	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
111780006226	ATP-sulfurylase; Region: ATPS; cd00517
111780006227	active site
111780006228	HXXH motif; other site
111780006229	flexible loop; other site
111780006230	Caspase domain; Region: Peptidase_C14; pfam00656
111780006231	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
111780006232	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
111780006233	Probable Catalytic site; other site
111780006234	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
111780006235	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
111780006236	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780006237	catalytic residue [active]
111780006238	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
111780006239	RNase_H superfamily; Region: RNase_H_2; pfam13482
111780006240	photosystem I subunit VII; Region: psaC; CHL00065
111780006241	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
111780006242	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
111780006243	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
111780006244	putative hydrophobic ligand binding site [chemical binding]; other site
111780006245	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
111780006246	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
111780006247	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
111780006248	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
111780006249	putative active site [active]
111780006250	catalytic triad [active]
111780006251	putative dimer interface [polypeptide binding]; other site
111780006252	Ion channel; Region: Ion_trans_2; pfam07885
111780006253	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780006254	TrkA-N domain; Region: TrkA_N; pfam02254
111780006255	TrkA-C domain; Region: TrkA_C; pfam02080
111780006256	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
111780006257	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
111780006258	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
111780006259	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780006260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780006261	homodimer interface [polypeptide binding]; other site
111780006262	catalytic residue [active]
111780006263	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
111780006264	Ankyrin repeat; Region: Ank; pfam00023
111780006265	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
111780006266	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
111780006267	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
111780006268	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
111780006269	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
111780006270	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
111780006271	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
111780006272	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
111780006273	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
111780006274	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
111780006275	CBD_II domain; Region: CBD_II; smart00637
111780006276	CBD_II domain; Region: CBD_II; smart00637
111780006277	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
111780006278	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
111780006279	Amidinotransferase; Region: Amidinotransf; cl12043
111780006280	Uncharacterized conserved protein [Function unknown]; Region: COG1915
111780006281	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
111780006282	homodimer interface [polypeptide binding]; other site
111780006283	cytosine deaminase-like protein; Validated; Region: PRK07583
111780006284	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
111780006285	active site
111780006286	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
111780006287	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
111780006288	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
111780006289	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
111780006290	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780006291	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
111780006292	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
111780006293	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
111780006294	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
111780006295	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780006296	DRTGG domain; Region: DRTGG; pfam07085
111780006297	carotene isomerase; Region: carot_isom; TIGR02730
111780006298	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780006299	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780006300	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780006301	active site
111780006302	ATP binding site [chemical binding]; other site
111780006303	substrate binding site [chemical binding]; other site
111780006304	activation loop (A-loop); other site
111780006305	GAF domain; Region: GAF_2; pfam13185
111780006306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780006307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780006308	dimer interface [polypeptide binding]; other site
111780006309	phosphorylation site [posttranslational modification]
111780006310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780006311	ATP binding site [chemical binding]; other site
111780006312	Mg2+ binding site [ion binding]; other site
111780006313	G-X-G motif; other site
111780006314	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
111780006315	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
111780006316	active site
111780006317	catalytic site [active]
111780006318	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
111780006319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006320	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
111780006321	putative ADP-binding pocket [chemical binding]; other site
111780006322	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
111780006323	Clp protease ATP binding subunit; Region: clpC; CHL00095
111780006324	Clp amino terminal domain; Region: Clp_N; pfam02861
111780006325	Clp amino terminal domain; Region: Clp_N; pfam02861
111780006326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780006327	Walker A motif; other site
111780006328	ATP binding site [chemical binding]; other site
111780006329	Walker B motif; other site
111780006330	arginine finger; other site
111780006331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780006332	Walker A motif; other site
111780006333	ATP binding site [chemical binding]; other site
111780006334	Walker B motif; other site
111780006335	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
111780006336	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
111780006337	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
111780006338	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
111780006339	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780006340	Probable transposase; Region: OrfB_IS605; pfam01385
111780006341	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780006342	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
111780006343	active site
111780006344	dimer interface [polypeptide binding]; other site
111780006345	metal binding site [ion binding]; metal-binding site
111780006346	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
111780006347	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
111780006348	active site
111780006349	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780006350	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780006351	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
111780006352	Walker A/P-loop; other site
111780006353	ATP binding site [chemical binding]; other site
111780006354	Q-loop/lid; other site
111780006355	ABC transporter signature motif; other site
111780006356	Walker B; other site
111780006357	D-loop; other site
111780006358	H-loop/switch region; other site
111780006359	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
111780006360	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
111780006361	Tetramer interface [polypeptide binding]; other site
111780006362	active site
111780006363	FMN-binding site [chemical binding]; other site
111780006364	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
111780006365	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
111780006366	putative di-iron ligands [ion binding]; other site
111780006367	Cache domain; Region: Cache_1; pfam02743
111780006368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780006369	dimerization interface [polypeptide binding]; other site
111780006370	PAS domain S-box; Region: sensory_box; TIGR00229
111780006371	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780006372	putative active site [active]
111780006373	heme pocket [chemical binding]; other site
111780006374	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
111780006375	glutaminase A; Region: Gln_ase; TIGR03814
111780006376	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
111780006377	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780006378	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
111780006379	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
111780006380	acyl-activating enzyme (AAE) consensus motif; other site
111780006381	active site
111780006382	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
111780006383	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
111780006384	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
111780006385	P loop; other site
111780006386	Nucleotide binding site [chemical binding]; other site
111780006387	DTAP/Switch II; other site
111780006388	Switch I; other site
111780006389	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
111780006390	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
111780006391	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
111780006392	nucleoside/Zn binding site; other site
111780006393	dimer interface [polypeptide binding]; other site
111780006394	catalytic motif [active]
111780006395	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780006396	TrkA-N domain; Region: TrkA_N; pfam02254
111780006397	TrkA-C domain; Region: TrkA_C; pfam02080
111780006398	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
111780006399	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
111780006400	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780006401	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780006402	active site
111780006403	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780006404	TPR repeat; Region: TPR_11; pfam13414
111780006405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006406	binding surface
111780006407	TPR motif; other site
111780006408	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780006409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006410	binding surface
111780006411	TPR motif; other site
111780006412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006413	binding surface
111780006414	TPR motif; other site
111780006415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006416	binding surface
111780006417	TPR motif; other site
111780006418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006419	binding surface
111780006420	TPR motif; other site
111780006421	TPR repeat; Region: TPR_11; pfam13414
111780006422	Protein of unknown function (DUF563); Region: DUF563; pfam04577
111780006423	TPR repeat; Region: TPR_11; pfam13414
111780006424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006425	binding surface
111780006426	TPR repeat; Region: TPR_11; pfam13414
111780006427	TPR motif; other site
111780006428	TPR repeat; Region: TPR_11; pfam13414
111780006429	TPR repeat; Region: TPR_11; pfam13414
111780006430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006431	binding surface
111780006432	TPR motif; other site
111780006433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780006434	Methyltransferase domain; Region: Methyltransf_24; pfam13578
111780006435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006436	binding surface
111780006437	TPR motif; other site
111780006438	TPR repeat; Region: TPR_11; pfam13414
111780006439	TPR repeat; Region: TPR_11; pfam13414
111780006440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006441	binding surface
111780006442	TPR motif; other site
111780006443	TPR repeat; Region: TPR_11; pfam13414
111780006444	TPR repeat; Region: TPR_11; pfam13414
111780006445	TPR repeat; Region: TPR_11; pfam13414
111780006446	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006447	binding surface
111780006448	TPR motif; other site
111780006449	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780006450	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006451	binding surface
111780006452	TPR motif; other site
111780006453	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
111780006454	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
111780006455	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780006456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780006457	S-adenosylmethionine binding site [chemical binding]; other site
111780006458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780006459	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
111780006460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780006461	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780006462	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780006463	dimerization interface [polypeptide binding]; other site
111780006464	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780006465	dimer interface [polypeptide binding]; other site
111780006466	phosphorylation site [posttranslational modification]
111780006467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780006468	ATP binding site [chemical binding]; other site
111780006469	Mg2+ binding site [ion binding]; other site
111780006470	G-X-G motif; other site
111780006471	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
111780006472	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
111780006473	NAD(P) binding site [chemical binding]; other site
111780006474	homotetramer interface [polypeptide binding]; other site
111780006475	homodimer interface [polypeptide binding]; other site
111780006476	active site
111780006477	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
111780006478	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
111780006479	NADP binding site [chemical binding]; other site
111780006480	active site
111780006481	putative substrate binding site [chemical binding]; other site
111780006482	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780006483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006484	active site
111780006485	phosphorylation site [posttranslational modification]
111780006486	intermolecular recognition site; other site
111780006487	dimerization interface [polypeptide binding]; other site
111780006488	lipoyl synthase; Provisional; Region: PRK12928
111780006489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780006490	FeS/SAM binding site; other site
111780006491	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
111780006492	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
111780006493	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
111780006494	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
111780006495	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
111780006496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006497	binding surface
111780006498	TPR motif; other site
111780006499	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
111780006500	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
111780006501	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780006502	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780006503	active site
111780006504	catalytic tetrad [active]
111780006505	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780006506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780006507	metal binding site [ion binding]; metal-binding site
111780006508	active site
111780006509	I-site; other site
111780006510	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780006511	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780006512	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780006513	metal binding site [ion binding]; metal-binding site
111780006514	active site
111780006515	I-site; other site
111780006516	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
111780006517	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
111780006518	Family description; Region: UvrD_C_2; pfam13538
111780006519	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
111780006520	PIN domain; Region: PIN_3; pfam13470
111780006521	Response regulator receiver domain; Region: Response_reg; pfam00072
111780006522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006523	active site
111780006524	phosphorylation site [posttranslational modification]
111780006525	intermolecular recognition site; other site
111780006526	dimerization interface [polypeptide binding]; other site
111780006527	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
111780006528	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
111780006529	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780006530	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
111780006531	ligand binding site [chemical binding]; other site
111780006532	flexible hinge region; other site
111780006533	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
111780006534	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
111780006535	putative active site [active]
111780006536	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780006537	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
111780006538	Walker A/P-loop; other site
111780006539	ATP binding site [chemical binding]; other site
111780006540	Q-loop/lid; other site
111780006541	ABC transporter signature motif; other site
111780006542	Walker B; other site
111780006543	D-loop; other site
111780006544	H-loop/switch region; other site
111780006545	Homeodomain-like domain; Region: HTH_23; pfam13384
111780006546	Winged helix-turn helix; Region: HTH_29; pfam13551
111780006547	Winged helix-turn helix; Region: HTH_33; pfam13592
111780006548	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
111780006549	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
111780006550	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
111780006551	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
111780006552	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780006553	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780006554	active site
111780006555	catalytic tetrad [active]
111780006556	Phosphotransferase enzyme family; Region: APH; pfam01636
111780006557	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
111780006558	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
111780006559	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
111780006560	putative active site [active]
111780006561	PRC-barrel domain; Region: PRC; pfam05239
111780006562	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
111780006563	PRC-barrel domain; Region: PRC; pfam05239
111780006564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
111780006565	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
111780006566	Response regulator receiver domain; Region: Response_reg; pfam00072
111780006567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006568	active site
111780006569	phosphorylation site [posttranslational modification]
111780006570	intermolecular recognition site; other site
111780006571	dimerization interface [polypeptide binding]; other site
111780006572	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
111780006573	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780006574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780006575	S-adenosylmethionine binding site [chemical binding]; other site
111780006576	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
111780006577	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
111780006578	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
111780006579	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780006580	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006581	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
111780006582	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006583	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
111780006584	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780006585	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006586	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
111780006587	putative ADP-binding pocket [chemical binding]; other site
111780006588	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780006589	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
111780006590	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006591	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780006592	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
111780006593	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006594	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
111780006595	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780006596	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
111780006597	putative ADP-binding pocket [chemical binding]; other site
111780006598	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780006599	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
111780006600	putative metal binding site; other site
111780006601	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
111780006602	active site
111780006603	catalytic site [active]
111780006604	substrate binding site [chemical binding]; other site
111780006605	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
111780006606	glyoxylate reductase; Reviewed; Region: PRK13243
111780006607	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
111780006608	dimerization interface [polypeptide binding]; other site
111780006609	ligand binding site [chemical binding]; other site
111780006610	NADP binding site [chemical binding]; other site
111780006611	catalytic site [active]
111780006612	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
111780006613	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
111780006614	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
111780006615	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
111780006616	Tetratricopeptide repeat; Region: TPR_6; pfam13174
111780006617	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
111780006618	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
111780006619	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
111780006620	N-acetyl-D-glucosamine binding site [chemical binding]; other site
111780006621	catalytic residue [active]
111780006622	Predicted membrane protein [Function unknown]; Region: COG2149
111780006623	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
111780006624	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780006625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780006626	S-adenosylmethionine binding site [chemical binding]; other site
111780006627	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780006628	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
111780006629	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
111780006630	active site
111780006631	dimer interface [polypeptide binding]; other site
111780006632	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
111780006633	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
111780006634	active site
111780006635	FMN binding site [chemical binding]; other site
111780006636	substrate binding site [chemical binding]; other site
111780006637	3Fe-4S cluster binding site [ion binding]; other site
111780006638	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
111780006639	domain interface; other site
111780006640	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
111780006641	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780006642	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
111780006643	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
111780006644	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
111780006645	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
111780006646	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
111780006647	ATP-grasp domain; Region: ATP-grasp_4; cl17255
111780006648	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
111780006649	IMP binding site; other site
111780006650	dimer interface [polypeptide binding]; other site
111780006651	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
111780006652	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
111780006653	putative active site [active]
111780006654	PhoH-like protein; Region: PhoH; pfam02562
111780006655	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780006656	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
111780006657	dihydroorotase; Provisional; Region: PRK07369
111780006658	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
111780006659	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
111780006660	active site
111780006661	4-alpha-glucanotransferase; Provisional; Region: PRK14508
111780006662	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
111780006663	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
111780006664	G1 box; other site
111780006665	GTP/Mg2+ binding site [chemical binding]; other site
111780006666	Switch I region; other site
111780006667	G2 box; other site
111780006668	Switch II region; other site
111780006669	G3 box; other site
111780006670	G4 box; other site
111780006671	G5 box; other site
111780006672	Domain of unknown function (DUF697); Region: DUF697; pfam05128
111780006673	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
111780006674	putative active site pocket [active]
111780006675	dimerization interface [polypeptide binding]; other site
111780006676	putative catalytic residue [active]
111780006677	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
111780006678	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
111780006679	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
111780006680	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
111780006681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780006682	dimer interface [polypeptide binding]; other site
111780006683	conserved gate region; other site
111780006684	putative PBP binding loops; other site
111780006685	ABC-ATPase subunit interface; other site
111780006686	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
111780006687	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
111780006688	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
111780006689	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
111780006690	TM-ABC transporter signature motif; other site
111780006691	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
111780006692	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
111780006693	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780006694	motif II; other site
111780006695	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
111780006696	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
111780006697	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
111780006698	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
111780006699	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780006700	catalytic residue [active]
111780006701	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
111780006702	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
111780006703	homodimer interface [polypeptide binding]; other site
111780006704	oligonucleotide binding site [chemical binding]; other site
111780006705	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
111780006706	RNA/DNA hybrid binding site [nucleotide binding]; other site
111780006707	active site
111780006708	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
111780006709	prephenate dehydratase; Provisional; Region: PRK11898
111780006710	Prephenate dehydratase; Region: PDT; pfam00800
111780006711	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
111780006712	putative L-Phe binding site [chemical binding]; other site
111780006713	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
111780006714	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
111780006715	elongation factor Tu; Region: tufA; CHL00071
111780006716	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
111780006717	G1 box; other site
111780006718	GEF interaction site [polypeptide binding]; other site
111780006719	GTP/Mg2+ binding site [chemical binding]; other site
111780006720	Switch I region; other site
111780006721	G2 box; other site
111780006722	G3 box; other site
111780006723	Switch II region; other site
111780006724	G4 box; other site
111780006725	G5 box; other site
111780006726	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
111780006727	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
111780006728	Antibiotic Binding Site [chemical binding]; other site
111780006729	elongation factor G; Reviewed; Region: PRK00007
111780006730	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
111780006731	G1 box; other site
111780006732	putative GEF interaction site [polypeptide binding]; other site
111780006733	GTP/Mg2+ binding site [chemical binding]; other site
111780006734	Switch I region; other site
111780006735	G2 box; other site
111780006736	G3 box; other site
111780006737	Switch II region; other site
111780006738	G4 box; other site
111780006739	G5 box; other site
111780006740	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
111780006741	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
111780006742	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
111780006743	30S ribosomal protein S7; Validated; Region: PRK05302
111780006744	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
111780006745	S17 interaction site [polypeptide binding]; other site
111780006746	S8 interaction site; other site
111780006747	16S rRNA interaction site [nucleotide binding]; other site
111780006748	streptomycin interaction site [chemical binding]; other site
111780006749	23S rRNA interaction site [nucleotide binding]; other site
111780006750	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
111780006751	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
111780006752	Cupin domain; Region: Cupin_2; cl17218
111780006753	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
111780006754	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
111780006755	active site
111780006756	dimer interface [polypeptide binding]; other site
111780006757	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
111780006758	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
111780006759	active site
111780006760	FMN binding site [chemical binding]; other site
111780006761	substrate binding site [chemical binding]; other site
111780006762	3Fe-4S cluster binding site [ion binding]; other site
111780006763	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
111780006764	domain interface; other site
111780006765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780006766	Probable transposase; Region: OrfB_IS605; pfam01385
111780006767	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780006768	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
111780006769	active site
111780006770	Predicted membrane protein [Function unknown]; Region: COG2324
111780006771	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
111780006772	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
111780006773	putative anticodon binding site; other site
111780006774	dimer interface [polypeptide binding]; other site
111780006775	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
111780006776	motif 1; other site
111780006777	active site
111780006778	motif 2; other site
111780006779	motif 3; other site
111780006780	KTSC domain; Region: KTSC; pfam13619
111780006781	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780006782	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780006783	active site
111780006784	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780006785	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
111780006786	Tic20-like protein; Region: Tic20; pfam09685
111780006787	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
111780006788	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
111780006789	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
111780006790	S-layer homology domain; Region: SLH; pfam00395
111780006791	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780006792	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780006793	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
111780006794	substrate binding pocket [chemical binding]; other site
111780006795	membrane-bound complex binding site; other site
111780006796	hinge residues; other site
111780006797	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
111780006798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780006799	dimer interface [polypeptide binding]; other site
111780006800	conserved gate region; other site
111780006801	putative PBP binding loops; other site
111780006802	ABC-ATPase subunit interface; other site
111780006803	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
111780006804	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
111780006805	Walker A/P-loop; other site
111780006806	ATP binding site [chemical binding]; other site
111780006807	Q-loop/lid; other site
111780006808	ABC transporter signature motif; other site
111780006809	Walker B; other site
111780006810	D-loop; other site
111780006811	H-loop/switch region; other site
111780006812	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
111780006813	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
111780006814	Walker A/P-loop; other site
111780006815	ATP binding site [chemical binding]; other site
111780006816	Q-loop/lid; other site
111780006817	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
111780006818	ABC transporter signature motif; other site
111780006819	Walker B; other site
111780006820	D-loop; other site
111780006821	H-loop/switch region; other site
111780006822	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
111780006823	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
111780006824	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
111780006825	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
111780006826	active site
111780006827	SAM binding site [chemical binding]; other site
111780006828	homodimer interface [polypeptide binding]; other site
111780006829	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
111780006830	Cytochrome c; Region: Cytochrom_C; cl11414
111780006831	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
111780006832	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
111780006833	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
111780006834	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
111780006835	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
111780006836	Walker A/P-loop; other site
111780006837	ATP binding site [chemical binding]; other site
111780006838	Q-loop/lid; other site
111780006839	ABC transporter signature motif; other site
111780006840	Walker B; other site
111780006841	D-loop; other site
111780006842	H-loop/switch region; other site
111780006843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006844	TPR motif; other site
111780006845	binding surface
111780006846	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
111780006847	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
111780006848	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
111780006849	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
111780006850	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
111780006851	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
111780006852	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
111780006853	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
111780006854	active site
111780006855	NTP binding site [chemical binding]; other site
111780006856	metal binding triad [ion binding]; metal-binding site
111780006857	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
111780006858	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
111780006859	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
111780006860	nudix motif; other site
111780006861	argininosuccinate lyase; Provisional; Region: PRK00855
111780006862	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
111780006863	active sites [active]
111780006864	tetramer interface [polypeptide binding]; other site
111780006865	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780006866	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
111780006867	GAF domain; Region: GAF; cl17456
111780006868	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
111780006869	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
111780006870	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
111780006871	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780006872	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
111780006873	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
111780006874	active site
111780006875	HIGH motif; other site
111780006876	dimer interface [polypeptide binding]; other site
111780006877	KMSKS motif; other site
111780006878	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
111780006879	FAD binding site [chemical binding]; other site
111780006880	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780006881	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780006882	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780006883	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780006884	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780006885	active site
111780006886	ATP binding site [chemical binding]; other site
111780006887	substrate binding site [chemical binding]; other site
111780006888	activation loop (A-loop); other site
111780006889	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780006890	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
111780006891	active site
111780006892	metal binding site [ion binding]; metal-binding site
111780006893	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
111780006894	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
111780006895	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
111780006896	nucleotide binding site [chemical binding]; other site
111780006897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780006898	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780006899	putative substrate translocation pore; other site
111780006900	light-harvesting-like protein 3; Provisional; Region: PLN00014
111780006901	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
111780006902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780006903	putative active site [active]
111780006904	heme pocket [chemical binding]; other site
111780006905	GAF domain; Region: GAF; pfam01590
111780006906	Phytochrome region; Region: PHY; pfam00360
111780006907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780006908	dimer interface [polypeptide binding]; other site
111780006909	phosphorylation site [posttranslational modification]
111780006910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780006911	ATP binding site [chemical binding]; other site
111780006912	Mg2+ binding site [ion binding]; other site
111780006913	G-X-G motif; other site
111780006914	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780006915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006916	active site
111780006917	phosphorylation site [posttranslational modification]
111780006918	intermolecular recognition site; other site
111780006919	dimerization interface [polypeptide binding]; other site
111780006920	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780006921	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780006922	ligand binding site [chemical binding]; other site
111780006923	flexible hinge region; other site
111780006924	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
111780006925	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
111780006926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780006927	active site
111780006928	phosphorylation site [posttranslational modification]
111780006929	intermolecular recognition site; other site
111780006930	dimerization interface [polypeptide binding]; other site
111780006931	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
111780006932	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
111780006933	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780006934	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
111780006935	putative metal binding site; other site
111780006936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006937	binding surface
111780006938	TPR motif; other site
111780006939	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
111780006940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780006941	binding surface
111780006942	TPR motif; other site
111780006943	TPR repeat; Region: TPR_11; pfam13414
111780006944	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
111780006945	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
111780006946	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
111780006947	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
111780006948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780006949	BT1 family; Region: BT1; pfam03092
111780006950	putative substrate translocation pore; other site
111780006951	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780006952	Ligand Binding Site [chemical binding]; other site
111780006953	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780006954	Ligand Binding Site [chemical binding]; other site
111780006955	cobalamin synthase; Reviewed; Region: cobS; PRK00235
111780006956	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
111780006957	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
111780006958	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780006959	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780006960	ligand binding site [chemical binding]; other site
111780006961	flexible hinge region; other site
111780006962	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
111780006963	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
111780006964	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
111780006965	protein binding site [polypeptide binding]; other site
111780006966	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
111780006967	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
111780006968	homodimer interface [polypeptide binding]; other site
111780006969	substrate-cofactor binding pocket; other site
111780006970	catalytic residue [active]
111780006971	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
111780006972	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
111780006973	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
111780006974	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
111780006975	UbiA prenyltransferase family; Region: UbiA; pfam01040
111780006976	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
111780006977	chorismate binding enzyme; Region: Chorismate_bind; cl10555
111780006978	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
111780006979	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
111780006980	dimer interface [polypeptide binding]; other site
111780006981	tetramer interface [polypeptide binding]; other site
111780006982	PYR/PP interface [polypeptide binding]; other site
111780006983	TPP binding site [chemical binding]; other site
111780006984	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
111780006985	TPP-binding site; other site
111780006986	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
111780006987	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780006988	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780006989	phosphopeptide binding site; other site
111780006990	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780006991	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780006992	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780006993	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780006994	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
111780006995	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
111780006996	arginine decarboxylase; Provisional; Region: PRK05354
111780006997	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
111780006998	active site
111780006999	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
111780007000	catalytic residues [active]
111780007001	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
111780007002	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
111780007003	PemK-like protein; Region: PemK; pfam02452
111780007004	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
111780007005	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
111780007006	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
111780007007	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
111780007008	metal binding site [ion binding]; metal-binding site
111780007009	DDE superfamily endonuclease; Region: DDE_4; pfam13359
111780007010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
111780007011	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
111780007012	Uncharacterized conserved protein [Function unknown]; Region: COG2308
111780007013	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
111780007014	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
111780007015	NAD(P) binding site [chemical binding]; other site
111780007016	putative active site [active]
111780007017	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
111780007018	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
111780007019	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780007020	dimer interface [polypeptide binding]; other site
111780007021	conserved gate region; other site
111780007022	putative PBP binding loops; other site
111780007023	ABC-ATPase subunit interface; other site
111780007024	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
111780007025	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780007026	cofactor binding site; other site
111780007027	DNA binding site [nucleotide binding]
111780007028	substrate interaction site [chemical binding]; other site
111780007029	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780007030	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
111780007031	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
111780007032	active site
111780007033	substrate binding site [chemical binding]; other site
111780007034	cosubstrate binding site; other site
111780007035	catalytic site [active]
111780007036	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780007037	putative active site [active]
111780007038	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
111780007039	Part of AAA domain; Region: AAA_19; pfam13245
111780007040	Family description; Region: UvrD_C_2; pfam13538
111780007041	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780007042	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780007043	putative active site [active]
111780007044	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
111780007045	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
111780007046	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
111780007047	putative active site [active]
111780007048	aspartate kinase; Provisional; Region: PRK07431
111780007049	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
111780007050	putative catalytic residues [active]
111780007051	putative nucleotide binding site [chemical binding]; other site
111780007052	putative aspartate binding site [chemical binding]; other site
111780007053	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
111780007054	putative allosteric regulatory site; other site
111780007055	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
111780007056	putative allosteric regulatory residue; other site
111780007057	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
111780007058	putative allosteric regulatory site; other site
111780007059	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
111780007060	putative allosteric regulatory residue; other site
111780007061	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
111780007062	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780007063	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
111780007064	Sulfatase; Region: Sulfatase; pfam00884
111780007065	DNA polymerase III subunit delta'; Validated; Region: PRK07399
111780007066	DNA polymerase III subunit delta'; Validated; Region: PRK08485
111780007067	ScpA/B protein; Region: ScpA_ScpB; cl00598
111780007068	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
111780007069	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
111780007070	active site
111780007071	Substrate binding site; other site
111780007072	Mg++ binding site; other site
111780007073	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
111780007074	putative trimer interface [polypeptide binding]; other site
111780007075	putative CoA binding site [chemical binding]; other site
111780007076	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780007077	HSP70 interaction site [polypeptide binding]; other site
111780007078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780007079	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780007080	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780007081	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
111780007082	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
111780007083	Walker A/P-loop; other site
111780007084	ATP binding site [chemical binding]; other site
111780007085	Q-loop/lid; other site
111780007086	ABC transporter signature motif; other site
111780007087	Walker B; other site
111780007088	D-loop; other site
111780007089	H-loop/switch region; other site
111780007090	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
111780007091	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
111780007092	Walker A/P-loop; other site
111780007093	ATP binding site [chemical binding]; other site
111780007094	Q-loop/lid; other site
111780007095	ABC transporter signature motif; other site
111780007096	Walker B; other site
111780007097	D-loop; other site
111780007098	H-loop/switch region; other site
111780007099	mbt repeat; Region: MBT; cl17705
111780007100	Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573
111780007101	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
111780007102	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780007103	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
111780007104	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780007105	ATP binding site [chemical binding]; other site
111780007106	putative Mg++ binding site [ion binding]; other site
111780007107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780007108	nucleotide binding region [chemical binding]; other site
111780007109	ATP-binding site [chemical binding]; other site
111780007110	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
111780007111	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
111780007112	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
111780007113	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
111780007114	putative NAD(P) binding site [chemical binding]; other site
111780007115	putative active site [active]
111780007116	PUCC protein; Region: PUCC; pfam03209
111780007117	carboxylate-amine ligase; Provisional; Region: PRK13517
111780007118	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
111780007119	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
111780007120	dimer interface [polypeptide binding]; other site
111780007121	catalytic triad [active]
111780007122	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
111780007123	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
111780007124	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
111780007125	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
111780007126	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
111780007127	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
111780007128	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
111780007129	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
111780007130	nucleotide binding site [chemical binding]; other site
111780007131	NEF interaction site [polypeptide binding]; other site
111780007132	SBD interface [polypeptide binding]; other site
111780007133	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
111780007134	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780007135	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
111780007136	active site
111780007137	catalytic residues [active]
111780007138	DNA binding site [nucleotide binding]
111780007139	Int/Topo IB signature motif; other site
111780007140	D5 N terminal like; Region: D5_N; smart00885
111780007141	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
111780007142	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780007143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007144	active site
111780007145	phosphorylation site [posttranslational modification]
111780007146	intermolecular recognition site; other site
111780007147	dimerization interface [polypeptide binding]; other site
111780007148	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780007149	DNA binding residues [nucleotide binding]
111780007150	dimerization interface [polypeptide binding]; other site
111780007151	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
111780007152	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
111780007153	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
111780007154	active site
111780007155	PHP Thumb interface [polypeptide binding]; other site
111780007156	metal binding site [ion binding]; metal-binding site
111780007157	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
111780007158	protein-splicing catalytic site; other site
111780007159	thioester formation/cholesterol transfer; other site
111780007160	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
111780007161	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
111780007162	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
111780007163	YcfA-like protein; Region: YcfA; cl00752
111780007164	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780007165	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780007166	active site
111780007167	NTP binding site [chemical binding]; other site
111780007168	metal binding triad [ion binding]; metal-binding site
111780007169	antibiotic binding site [chemical binding]; other site
111780007170	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
111780007171	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780007172	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
111780007173	cofactor binding site; other site
111780007174	DNA binding site [nucleotide binding]
111780007175	substrate interaction site [chemical binding]; other site
111780007176	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780007177	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
111780007178	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780007179	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780007180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007181	active site
111780007182	phosphorylation site [posttranslational modification]
111780007183	intermolecular recognition site; other site
111780007184	dimerization interface [polypeptide binding]; other site
111780007185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780007186	DNA binding site [nucleotide binding]
111780007187	HAMP domain; Region: HAMP; pfam00672
111780007188	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780007189	dimer interface [polypeptide binding]; other site
111780007190	phosphorylation site [posttranslational modification]
111780007191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780007192	ATP binding site [chemical binding]; other site
111780007193	Mg2+ binding site [ion binding]; other site
111780007194	G-X-G motif; other site
111780007195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780007196	non-specific DNA binding site [nucleotide binding]; other site
111780007197	salt bridge; other site
111780007198	sequence-specific DNA binding site [nucleotide binding]; other site
111780007199	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
111780007200	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
111780007201	active site
111780007202	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780007203	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
111780007204	putative ADP-binding pocket [chemical binding]; other site
111780007205	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
111780007206	Phosphoglycerate kinase; Region: PGK; pfam00162
111780007207	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
111780007208	substrate binding site [chemical binding]; other site
111780007209	hinge regions; other site
111780007210	ADP binding site [chemical binding]; other site
111780007211	catalytic site [active]
111780007212	YGGT family; Region: YGGT; pfam02325
111780007213	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
111780007214	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780007215	DDE superfamily endonuclease; Region: DDE_5; cl17874
111780007216	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
111780007217	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
111780007218	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780007219	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780007220	homodimer interface [polypeptide binding]; other site
111780007221	catalytic residue [active]
111780007222	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
111780007223	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
111780007224	dimerization interface [polypeptide binding]; other site
111780007225	active site
111780007226	metal binding site [ion binding]; metal-binding site
111780007227	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
111780007228	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
111780007229	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
111780007230	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
111780007231	2TM domain; Region: 2TM; pfam13239
111780007232	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
111780007233	Peptidase family M50; Region: Peptidase_M50; pfam02163
111780007234	active site
111780007235	putative substrate binding region [chemical binding]; other site
111780007236	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
111780007237	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
111780007238	active site
111780007239	SAM binding site [chemical binding]; other site
111780007240	homodimer interface [polypeptide binding]; other site
111780007241	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
111780007242	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
111780007243	active site
111780007244	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
111780007245	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
111780007246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780007247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
111780007248	Ion channel; Region: Ion_trans_2; pfam07885
111780007249	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780007250	TrkA-N domain; Region: TrkA_N; pfam02254
111780007251	TrkA-C domain; Region: TrkA_C; pfam02080
111780007252	acetylornithine aminotransferase; Provisional; Region: PRK02627
111780007253	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
111780007254	inhibitor-cofactor binding pocket; inhibition site
111780007255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780007256	catalytic residue [active]
111780007257	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
111780007258	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780007259	structural tetrad; other site
111780007260	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780007261	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
111780007262	catalytic residues [active]
111780007263	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
111780007264	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
111780007265	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780007266	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
111780007267	ligand binding site [chemical binding]; other site
111780007268	flexible hinge region; other site
111780007269	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
111780007270	putative switch regulator; other site
111780007271	non-specific DNA interactions [nucleotide binding]; other site
111780007272	DNA binding site [nucleotide binding]
111780007273	sequence specific DNA binding site [nucleotide binding]; other site
111780007274	putative cAMP binding site [chemical binding]; other site
111780007275	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
111780007276	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
111780007277	NAD binding site [chemical binding]; other site
111780007278	homotetramer interface [polypeptide binding]; other site
111780007279	homodimer interface [polypeptide binding]; other site
111780007280	substrate binding site [chemical binding]; other site
111780007281	active site
111780007282	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
111780007283	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
111780007284	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
111780007285	chaperone protein DnaJ; Provisional; Region: PRK14299
111780007286	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780007287	HSP70 interaction site [polypeptide binding]; other site
111780007288	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
111780007289	substrate binding site [polypeptide binding]; other site
111780007290	dimer interface [polypeptide binding]; other site
111780007291	molecular chaperone DnaK; Provisional; Region: PRK13410
111780007292	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
111780007293	nucleotide binding site [chemical binding]; other site
111780007294	NEF interaction site [polypeptide binding]; other site
111780007295	SBD interface [polypeptide binding]; other site
111780007296	Uncharacterized conserved protein [Function unknown]; Region: COG2836
111780007297	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
111780007298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
111780007299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780007300	Probable transposase; Region: OrfB_IS605; pfam01385
111780007301	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
111780007302	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
111780007303	Response regulator receiver domain; Region: Response_reg; pfam00072
111780007304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007305	active site
111780007306	phosphorylation site [posttranslational modification]
111780007307	intermolecular recognition site; other site
111780007308	dimerization interface [polypeptide binding]; other site
111780007309	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780007310	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780007311	putative active site [active]
111780007312	heme pocket [chemical binding]; other site
111780007313	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780007314	dimer interface [polypeptide binding]; other site
111780007315	phosphorylation site [posttranslational modification]
111780007316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780007317	ATP binding site [chemical binding]; other site
111780007318	Mg2+ binding site [ion binding]; other site
111780007319	G-X-G motif; other site
111780007320	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
111780007321	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
111780007322	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
111780007323	G-X-X-G motif; other site
111780007324	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
111780007325	RxxxH motif; other site
111780007326	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
111780007327	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
111780007328	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
111780007329	Bacterial PH domain; Region: DUF304; pfam03703
111780007330	ribonuclease P; Reviewed; Region: rnpA; PRK03031
111780007331	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
111780007332	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
111780007333	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
111780007334	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
111780007335	DXD motif; other site
111780007336	Cellulose synthase-like protein; Region: PLN02893
111780007337	PilZ domain; Region: PilZ; pfam07238
111780007338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
111780007339	Protein of unknown function, DUF482; Region: DUF482; pfam04339
111780007340	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
111780007341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
111780007342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780007343	Coenzyme A binding pocket [chemical binding]; other site
111780007344	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780007345	putative active site [active]
111780007346	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
111780007347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780007348	Walker A/P-loop; other site
111780007349	ATP binding site [chemical binding]; other site
111780007350	Q-loop/lid; other site
111780007351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780007352	ABC transporter signature motif; other site
111780007353	Walker B; other site
111780007354	D-loop; other site
111780007355	H-loop/switch region; other site
111780007356	hypothetical protein; Provisional; Region: PRK06850
111780007357	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
111780007358	Active Sites [active]
111780007359	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
111780007360	active site
111780007361	DGQHR domain; Region: DGQHR; TIGR03187
111780007362	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
111780007363	putative active site [active]
111780007364	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
111780007365	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
111780007366	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780007367	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780007368	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780007369	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780007370	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
111780007371	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
111780007372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780007373	Walker A motif; other site
111780007374	ATP binding site [chemical binding]; other site
111780007375	Walker B motif; other site
111780007376	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
111780007377	Clp protease; Region: CLP_protease; pfam00574
111780007378	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
111780007379	oligomer interface [polypeptide binding]; other site
111780007380	active site residues [active]
111780007381	trigger factor; Provisional; Region: tig; PRK01490
111780007382	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
111780007383	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
111780007384	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
111780007385	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
111780007386	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
111780007387	dihydrodipicolinate synthase; Region: dapA; TIGR00674
111780007388	dimer interface [polypeptide binding]; other site
111780007389	active site
111780007390	catalytic residue [active]
111780007391	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
111780007392	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
111780007393	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
111780007394	ribosomal protein L32; Validated; Region: rpl32; CHL00152
111780007395	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
111780007396	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
111780007397	Moco binding site; other site
111780007398	metal coordination site [ion binding]; other site
111780007399	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
111780007400	heme binding pocket [chemical binding]; other site
111780007401	heme ligand [chemical binding]; other site
111780007402	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
111780007403	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
111780007404	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780007405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007406	active site
111780007407	phosphorylation site [posttranslational modification]
111780007408	intermolecular recognition site; other site
111780007409	dimerization interface [polypeptide binding]; other site
111780007410	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780007411	DNA binding site [nucleotide binding]
111780007412	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
111780007413	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
111780007414	purine monophosphate binding site [chemical binding]; other site
111780007415	dimer interface [polypeptide binding]; other site
111780007416	putative catalytic residues [active]
111780007417	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
111780007418	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
111780007419	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
111780007420	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780007421	binding surface
111780007422	TPR motif; other site
111780007423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007424	TPR repeat; Region: TPR_11; pfam13414
111780007425	binding surface
111780007426	TPR motif; other site
111780007427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007428	binding surface
111780007429	TPR motif; other site
111780007430	TPR repeat; Region: TPR_11; pfam13414
111780007431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007432	binding surface
111780007433	TPR motif; other site
111780007434	TPR repeat; Region: TPR_11; pfam13414
111780007435	V4R domain; Region: V4R; cl15268
111780007436	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
111780007437	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
111780007438	G1 box; other site
111780007439	GTP/Mg2+ binding site [chemical binding]; other site
111780007440	G2 box; other site
111780007441	Switch I region; other site
111780007442	G3 box; other site
111780007443	Switch II region; other site
111780007444	G4 box; other site
111780007445	G5 box; other site
111780007446	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
111780007447	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780007448	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
111780007449	Proline dehydrogenase; Region: Pro_dh; pfam01619
111780007450	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
111780007451	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
111780007452	Glutamate binding site [chemical binding]; other site
111780007453	homodimer interface [polypeptide binding]; other site
111780007454	NAD binding site [chemical binding]; other site
111780007455	catalytic residues [active]
111780007456	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780007457	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780007458	active site
111780007459	ATP binding site [chemical binding]; other site
111780007460	substrate binding site [chemical binding]; other site
111780007461	activation loop (A-loop); other site
111780007462	YcxB-like protein; Region: YcxB; pfam14317
111780007463	TPR repeat; Region: TPR_11; pfam13414
111780007464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007465	TPR motif; other site
111780007466	binding surface
111780007467	TPR repeat; Region: TPR_11; pfam13414
111780007468	Tetratricopeptide repeat; Region: TPR_1; pfam00515
111780007469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007470	binding surface
111780007471	TPR motif; other site
111780007472	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780007473	Tetratricopeptide repeat; Region: TPR_1; pfam00515
111780007474	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007475	binding surface
111780007476	TPR motif; other site
111780007477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007478	binding surface
111780007479	TPR motif; other site
111780007480	TPR repeat; Region: TPR_11; pfam13414
111780007481	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007482	binding surface
111780007483	TPR motif; other site
111780007484	TPR repeat; Region: TPR_11; pfam13414
111780007485	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780007486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007487	binding surface
111780007488	TPR motif; other site
111780007489	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007490	binding surface
111780007491	TPR motif; other site
111780007492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007493	binding surface
111780007494	TPR motif; other site
111780007495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007496	binding surface
111780007497	TPR motif; other site
111780007498	TPR repeat; Region: TPR_11; pfam13414
111780007499	YcxB-like protein; Region: YcxB; pfam14317
111780007500	YcxB-like protein; Region: YcxB; pfam14317
111780007501	YcxB-like protein; Region: YcxB; pfam14317
111780007502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780007503	TPR motif; other site
111780007504	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
111780007505	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
111780007506	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
111780007507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007508	TPR motif; other site
111780007509	TPR repeat; Region: TPR_11; pfam13414
111780007510	binding surface
111780007511	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
111780007512	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
111780007513	amphipathic channel; other site
111780007514	Asn-Pro-Ala signature motifs; other site
111780007515	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
111780007516	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
111780007517	putative substrate binding pocket [chemical binding]; other site
111780007518	dimer interface [polypeptide binding]; other site
111780007519	phosphate binding site [ion binding]; other site
111780007520	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
111780007521	Cytochrome B6-F complex subunit 5; Region: PetG; cl03637
111780007522	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
111780007523	Cytochrome c; Region: Cytochrom_C; pfam00034
111780007524	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
111780007525	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
111780007526	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
111780007527	Ligand Binding Site [chemical binding]; other site
111780007528	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
111780007529	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780007530	FeS/SAM binding site; other site
111780007531	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
111780007532	L-aspartate oxidase; Provisional; Region: PRK06175
111780007533	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
111780007534	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
111780007535	active site
111780007536	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780007537	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
111780007538	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
111780007539	active site
111780007540	catalytic site [active]
111780007541	Aamy_C domain; Region: Aamy_C; smart00632
111780007542	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
111780007543	starch-binding site 2 [chemical binding]; other site
111780007544	starch-binding site 1 [chemical binding]; other site
111780007545	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780007546	Predicted membrane protein [Function unknown]; Region: COG2259
111780007547	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
111780007548	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
111780007549	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
111780007550	Mechanosensitive ion channel; Region: MS_channel; pfam00924
111780007551	Response regulator receiver domain; Region: Response_reg; pfam00072
111780007552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007553	active site
111780007554	phosphorylation site [posttranslational modification]
111780007555	intermolecular recognition site; other site
111780007556	dimerization interface [polypeptide binding]; other site
111780007557	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
111780007558	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
111780007559	putative acyl-acceptor binding pocket; other site
111780007560	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
111780007561	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780007562	cofactor binding site; other site
111780007563	DNA binding site [nucleotide binding]
111780007564	substrate interaction site [chemical binding]; other site
111780007565	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780007566	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780007567	active site
111780007568	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
111780007569	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
111780007570	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
111780007571	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
111780007572	active site
111780007573	hydrophilic channel; other site
111780007574	dimerization interface [polypeptide binding]; other site
111780007575	catalytic residues [active]
111780007576	active site lid [active]
111780007577	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
111780007578	putative active site [active]
111780007579	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
111780007580	Rhomboid family; Region: Rhomboid; pfam01694
111780007581	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
111780007582	tartrate dehydrogenase; Region: TTC; TIGR02089
111780007583	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
111780007584	four helix bundle protein; Region: TIGR02436
111780007585	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
111780007586	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
111780007587	protein-splicing catalytic site; other site
111780007588	thioester formation/cholesterol transfer; other site
111780007589	HNH endonuclease; Region: HNH_3; pfam13392
111780007590	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
111780007591	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
111780007592	recombination protein F; Reviewed; Region: recF; PRK00064
111780007593	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
111780007594	Walker A/P-loop; other site
111780007595	ATP binding site [chemical binding]; other site
111780007596	Q-loop/lid; other site
111780007597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780007598	ABC transporter signature motif; other site
111780007599	Walker B; other site
111780007600	D-loop; other site
111780007601	H-loop/switch region; other site
111780007602	putative glycosyl transferase; Provisional; Region: PRK10307
111780007603	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
111780007604	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780007605	Chain length determinant protein; Region: Wzz; pfam02706
111780007606	Chain length determinant protein; Region: Wzz; cl15801
111780007607	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780007608	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780007609	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780007610	active site
111780007611	NTP binding site [chemical binding]; other site
111780007612	metal binding triad [ion binding]; metal-binding site
111780007613	antibiotic binding site [chemical binding]; other site
111780007614	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
111780007615	ABC-2 type transporter; Region: ABC2_membrane; cl17235
111780007616	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
111780007617	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
111780007618	Walker A/P-loop; other site
111780007619	ATP binding site [chemical binding]; other site
111780007620	Q-loop/lid; other site
111780007621	ABC transporter signature motif; other site
111780007622	Walker B; other site
111780007623	D-loop; other site
111780007624	H-loop/switch region; other site
111780007625	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
111780007626	putative carbohydrate binding site [chemical binding]; other site
111780007627	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780007628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780007629	S-adenosylmethionine binding site [chemical binding]; other site
111780007630	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
111780007631	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
111780007632	ligand binding site; other site
111780007633	tetramer interface; other site
111780007634	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
111780007635	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
111780007636	NeuB family; Region: NeuB; pfam03102
111780007637	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
111780007638	NeuB binding interface [polypeptide binding]; other site
111780007639	putative substrate binding site [chemical binding]; other site
111780007640	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
111780007641	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780007642	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
111780007643	active site
111780007644	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780007645	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
111780007646	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780007647	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780007648	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780007649	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780007650	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780007651	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
111780007652	active site
111780007653	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
111780007654	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780007655	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
111780007656	active site
111780007657	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
111780007658	transmembrane helices; other site
111780007659	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
111780007660	TrkA-C domain; Region: TrkA_C; pfam02080
111780007661	TrkA-C domain; Region: TrkA_C; pfam02080
111780007662	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
111780007663	Predicted permeases [General function prediction only]; Region: COG0795
111780007664	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
111780007665	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
111780007666	CoA binding domain; Region: CoA_binding_2; pfam13380
111780007667	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
111780007668	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
111780007669	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780007670	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780007671	Coenzyme A binding pocket [chemical binding]; other site
111780007672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780007673	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
111780007674	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
111780007675	HD domain; Region: HD_3; cl17350
111780007676	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
111780007677	UbiA prenyltransferase family; Region: UbiA; pfam01040
111780007678	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
111780007679	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
111780007680	Switch I; other site
111780007681	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
111780007682	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
111780007683	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
111780007684	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
111780007685	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
111780007686	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
111780007687	Walker A/P-loop; other site
111780007688	ATP binding site [chemical binding]; other site
111780007689	Q-loop/lid; other site
111780007690	ABC transporter signature motif; other site
111780007691	Walker B; other site
111780007692	D-loop; other site
111780007693	H-loop/switch region; other site
111780007694	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
111780007695	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780007696	active site
111780007697	Methyltransferase domain; Region: Methyltransf_24; pfam13578
111780007698	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
111780007699	Probable Catalytic site; other site
111780007700	metal-binding site
111780007701	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780007702	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
111780007703	Probable Catalytic site; other site
111780007704	metal-binding site
111780007705	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
111780007706	active site
111780007707	Rhomboid family; Region: Rhomboid; pfam01694
111780007708	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
111780007709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780007710	Coenzyme A binding pocket [chemical binding]; other site
111780007711	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
111780007712	active site
111780007713	dinuclear metal binding site [ion binding]; other site
111780007714	dimerization interface [polypeptide binding]; other site
111780007715	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
111780007716	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
111780007717	active site
111780007718	metal binding site [ion binding]; metal-binding site
111780007719	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
111780007720	aromatic arch; other site
111780007721	DCoH dimer interaction site [polypeptide binding]; other site
111780007722	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
111780007723	DCoH tetramer interaction site [polypeptide binding]; other site
111780007724	substrate binding site [chemical binding]; other site
111780007725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
111780007726	hypothetical protein; Validated; Region: PRK00029
111780007727	Uncharacterized conserved protein [Function unknown]; Region: COG0397
111780007728	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
111780007729	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
111780007730	glutaminase active site [active]
111780007731	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
111780007732	dimer interface [polypeptide binding]; other site
111780007733	active site
111780007734	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
111780007735	dimer interface [polypeptide binding]; other site
111780007736	active site
111780007737	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780007738	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780007739	phosphopeptide binding site; other site
111780007740	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780007741	haemagglutination activity domain; Region: Haemagg_act; pfam05860
111780007742	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
111780007743	CHAT domain; Region: CHAT; cl17868
111780007744	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
111780007745	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
111780007746	Surface antigen; Region: Bac_surface_Ag; pfam01103
111780007747	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780007748	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780007749	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780007750	active site
111780007751	ATP binding site [chemical binding]; other site
111780007752	substrate binding site [chemical binding]; other site
111780007753	activation loop (A-loop); other site
111780007754	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
111780007755	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780007756	substrate binding pocket [chemical binding]; other site
111780007757	Ion channel; Region: Ion_trans_2; pfam07885
111780007758	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780007759	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
111780007760	membrane-bound complex binding site; other site
111780007761	hinge residues; other site
111780007762	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780007763	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780007764	phosphopeptide binding site; other site
111780007765	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780007766	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780007767	structural tetrad; other site
111780007768	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
111780007769	phosphodiesterase; Provisional; Region: PRK12704
111780007770	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
111780007771	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
111780007772	Walker A/P-loop; other site
111780007773	ATP binding site [chemical binding]; other site
111780007774	Q-loop/lid; other site
111780007775	ABC transporter signature motif; other site
111780007776	Walker B; other site
111780007777	D-loop; other site
111780007778	H-loop/switch region; other site
111780007779	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
111780007780	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
111780007781	ABC-ATPase subunit  interface; other site
111780007782	dimer interface [polypeptide binding]; other site
111780007783	putative PBP binding regions; other site
111780007784	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
111780007785	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
111780007786	ABC-ATPase subunit  interface; other site
111780007787	dimer interface [polypeptide binding]; other site
111780007788	putative PBP binding regions; other site
111780007789	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
111780007790	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
111780007791	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
111780007792	Penicillin amidase; Region: Penicil_amidase; pfam01804
111780007793	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
111780007794	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
111780007795	active site
111780007796	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
111780007797	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
111780007798	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
111780007799	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
111780007800	inhibitor-cofactor binding pocket; inhibition site
111780007801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780007802	catalytic residue [active]
111780007803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780007804	S-adenosylmethionine binding site [chemical binding]; other site
111780007805	Condensation domain; Region: Condensation; pfam00668
111780007806	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
111780007807	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
111780007808	acyl-activating enzyme (AAE) consensus motif; other site
111780007809	AMP binding site [chemical binding]; other site
111780007810	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007811	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
111780007812	putative NAD(P) binding site [chemical binding]; other site
111780007813	active site
111780007814	putative substrate binding site [chemical binding]; other site
111780007815	Condensation domain; Region: Condensation; pfam00668
111780007816	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007817	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
111780007818	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
111780007819	acyl-activating enzyme (AAE) consensus motif; other site
111780007820	AMP binding site [chemical binding]; other site
111780007821	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007822	Condensation domain; Region: Condensation; pfam00668
111780007823	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007824	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
111780007825	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
111780007826	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
111780007827	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
111780007828	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
111780007829	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
111780007830	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
111780007831	acyl-activating enzyme (AAE) consensus motif; other site
111780007832	acyl-activating enzyme (AAE) consensus motif; other site
111780007833	AMP binding site [chemical binding]; other site
111780007834	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007835	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
111780007836	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
111780007837	inhibitor-cofactor binding pocket; inhibition site
111780007838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780007839	catalytic residue [active]
111780007840	Condensation domain; Region: Condensation; pfam00668
111780007841	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007842	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
111780007843	acyl-activating enzyme (AAE) consensus motif; other site
111780007844	AMP binding site [chemical binding]; other site
111780007845	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007846	Condensation domain; Region: Condensation; pfam00668
111780007847	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007848	Condensation domain; Region: Condensation; pfam00668
111780007849	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007850	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
111780007851	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
111780007852	acyl-activating enzyme (AAE) consensus motif; other site
111780007853	AMP binding site [chemical binding]; other site
111780007854	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007855	Condensation domain; Region: Condensation; pfam00668
111780007856	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007857	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
111780007858	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
111780007859	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
111780007860	active site
111780007861	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
111780007862	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
111780007863	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
111780007864	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
111780007865	putative NADP binding site [chemical binding]; other site
111780007866	active site
111780007867	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007868	acyl-CoA synthetase; Validated; Region: PRK05850
111780007869	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
111780007870	acyl-activating enzyme (AAE) consensus motif; other site
111780007871	active site
111780007872	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
111780007873	Condensation domain; Region: Condensation; pfam00668
111780007874	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
111780007875	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
111780007876	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
111780007877	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
111780007878	acyl-activating enzyme (AAE) consensus motif; other site
111780007879	AMP binding site [chemical binding]; other site
111780007880	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780007881	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
111780007882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780007883	AMIN domain; Region: AMIN; pfam11741
111780007884	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
111780007885	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
111780007886	N-terminal plug; other site
111780007887	ligand-binding site [chemical binding]; other site
111780007888	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
111780007889	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
111780007890	siderophore binding site; other site
111780007891	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
111780007892	H+ Antiporter protein; Region: 2A0121; TIGR00900
111780007893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780007894	putative substrate translocation pore; other site
111780007895	NIL domain; Region: NIL; pfam09383
111780007896	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
111780007897	ResB-like family; Region: ResB; pfam05140
111780007898	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
111780007899	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
111780007900	TPR repeat; Region: TPR_11; pfam13414
111780007901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007902	binding surface
111780007903	TPR motif; other site
111780007904	TPR repeat; Region: TPR_11; pfam13414
111780007905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007906	binding surface
111780007907	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780007908	TPR motif; other site
111780007909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007910	binding surface
111780007911	TPR motif; other site
111780007912	TPR repeat; Region: TPR_11; pfam13414
111780007913	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780007914	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
111780007915	TPR repeat; Region: TPR_11; pfam13414
111780007916	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780007917	binding surface
111780007918	TPR motif; other site
111780007919	hypothetical protein; Reviewed; Region: PRK00024
111780007920	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
111780007921	MPN+ (JAMM) motif; other site
111780007922	Zinc-binding site [ion binding]; other site
111780007923	Response regulator receiver domain; Region: Response_reg; pfam00072
111780007924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007925	active site
111780007926	phosphorylation site [posttranslational modification]
111780007927	intermolecular recognition site; other site
111780007928	dimerization interface [polypeptide binding]; other site
111780007929	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780007930	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780007931	metal binding site [ion binding]; metal-binding site
111780007932	active site
111780007933	I-site; other site
111780007934	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780007935	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780007936	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780007937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780007938	dimer interface [polypeptide binding]; other site
111780007939	phosphorylation site [posttranslational modification]
111780007940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780007941	ATP binding site [chemical binding]; other site
111780007942	Mg2+ binding site [ion binding]; other site
111780007943	G-X-G motif; other site
111780007944	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780007945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780007946	active site
111780007947	phosphorylation site [posttranslational modification]
111780007948	intermolecular recognition site; other site
111780007949	dimerization interface [polypeptide binding]; other site
111780007950	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
111780007951	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
111780007952	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
111780007953	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
111780007954	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
111780007955	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
111780007956	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892
111780007957	CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893
111780007958	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
111780007959	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
111780007960	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
111780007961	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782
111780007962	Uncharacterized conserved protein [Function unknown]; Region: COG2361
111780007963	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780007964	active site
111780007965	NTP binding site [chemical binding]; other site
111780007966	metal binding triad [ion binding]; metal-binding site
111780007967	antibiotic binding site [chemical binding]; other site
111780007968	Predicted transcriptional regulator [Transcription]; Region: COG2378
111780007969	WYL domain; Region: WYL; pfam13280
111780007970	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
111780007971	C-terminal peptidase (prc); Region: prc; TIGR00225
111780007972	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
111780007973	protein binding site [polypeptide binding]; other site
111780007974	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
111780007975	Catalytic dyad [active]
111780007976	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
111780007977	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
111780007978	Qi binding site; other site
111780007979	intrachain domain interface; other site
111780007980	interchain domain interface [polypeptide binding]; other site
111780007981	heme bH binding site [chemical binding]; other site
111780007982	heme bL binding site [chemical binding]; other site
111780007983	Qo binding site; other site
111780007984	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
111780007985	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
111780007986	interchain domain interface [polypeptide binding]; other site
111780007987	intrachain domain interface; other site
111780007988	Qi binding site; other site
111780007989	Qo binding site; other site
111780007990	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
111780007991	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
111780007992	G1 box; other site
111780007993	putative GEF interaction site [polypeptide binding]; other site
111780007994	GTP/Mg2+ binding site [chemical binding]; other site
111780007995	Switch I region; other site
111780007996	G2 box; other site
111780007997	G3 box; other site
111780007998	Switch II region; other site
111780007999	G4 box; other site
111780008000	G5 box; other site
111780008001	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
111780008002	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
111780008003	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780008004	hydroxyglutarate oxidase; Provisional; Region: PRK11728
111780008005	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
111780008006	active site
111780008007	Fe-S cluster binding site [ion binding]; other site
111780008008	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
111780008009	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
111780008010	substrate binding site [chemical binding]; other site
111780008011	hexamer interface [polypeptide binding]; other site
111780008012	metal binding site [ion binding]; metal-binding site
111780008013	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
111780008014	putative rRNA binding site [nucleotide binding]; other site
111780008015	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
111780008016	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
111780008017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780008018	dimer interface [polypeptide binding]; other site
111780008019	conserved gate region; other site
111780008020	putative PBP binding loops; other site
111780008021	ABC-ATPase subunit interface; other site
111780008022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780008023	dimer interface [polypeptide binding]; other site
111780008024	conserved gate region; other site
111780008025	putative PBP binding loops; other site
111780008026	ABC-ATPase subunit interface; other site
111780008027	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
111780008028	active site
111780008029	metal binding site [ion binding]; metal-binding site
111780008030	dimerization interface [polypeptide binding]; other site
111780008031	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
111780008032	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
111780008033	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
111780008034	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
111780008035	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780008036	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
111780008037	Type II transport protein GspH; Region: GspH; pfam12019
111780008038	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
111780008039	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
111780008040	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
111780008041	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
111780008042	TPR repeat; Region: TPR_11; pfam13414
111780008043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008044	binding surface
111780008045	TPR motif; other site
111780008046	TPR repeat; Region: TPR_11; pfam13414
111780008047	TPR repeat; Region: TPR_11; pfam13414
111780008048	Tetratricopeptide repeats; Region: TPR; smart00028
111780008049	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
111780008050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008051	binding surface
111780008052	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780008053	TPR motif; other site
111780008054	TPR repeat; Region: TPR_11; pfam13414
111780008055	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780008056	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008057	binding surface
111780008058	TPR motif; other site
111780008059	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
111780008060	TPR repeat; Region: TPR_11; pfam13414
111780008061	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008062	binding surface
111780008063	TPR motif; other site
111780008064	TPR repeat; Region: TPR_11; pfam13414
111780008065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008066	binding surface
111780008067	TPR motif; other site
111780008068	TPR repeat; Region: TPR_11; pfam13414
111780008069	TPR repeat; Region: TPR_11; pfam13414
111780008070	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008071	binding surface
111780008072	TPR motif; other site
111780008073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008074	TPR motif; other site
111780008075	TPR repeat; Region: TPR_11; pfam13414
111780008076	binding surface
111780008077	TPR repeat; Region: TPR_11; pfam13414
111780008078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008079	binding surface
111780008080	TPR motif; other site
111780008081	TPR repeat; Region: TPR_11; pfam13414
111780008082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008083	binding surface
111780008084	TPR motif; other site
111780008085	TPR repeat; Region: TPR_11; pfam13414
111780008086	TPR repeat; Region: TPR_11; pfam13414
111780008087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008088	TPR motif; other site
111780008089	binding surface
111780008090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008091	binding surface
111780008092	TPR motif; other site
111780008093	TPR repeat; Region: TPR_11; pfam13414
111780008094	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780008095	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780008096	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780008097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008098	TPR motif; other site
111780008099	TPR repeat; Region: TPR_11; pfam13414
111780008100	binding surface
111780008101	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780008102	TPR repeat; Region: TPR_11; pfam13414
111780008103	TPR repeat; Region: TPR_11; pfam13414
111780008104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008105	binding surface
111780008106	TPR motif; other site
111780008107	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780008108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008109	binding surface
111780008110	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780008111	TPR motif; other site
111780008112	TPR repeat; Region: TPR_11; pfam13414
111780008113	TPR repeat; Region: TPR_11; pfam13414
111780008114	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008115	binding surface
111780008116	TPR motif; other site
111780008117	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780008118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008119	binding surface
111780008120	TPR motif; other site
111780008121	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780008122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008123	binding surface
111780008124	TPR motif; other site
111780008125	TPR repeat; Region: TPR_11; pfam13414
111780008126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008127	TPR repeat; Region: TPR_11; pfam13414
111780008128	binding surface
111780008129	TPR motif; other site
111780008130	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780008131	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
111780008132	active site
111780008133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008134	TPR repeat; Region: TPR_11; pfam13414
111780008135	binding surface
111780008136	TPR motif; other site
111780008137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008138	binding surface
111780008139	TPR repeat; Region: TPR_11; pfam13414
111780008140	TPR motif; other site
111780008141	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780008142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008143	binding surface
111780008144	TPR motif; other site
111780008145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008146	binding surface
111780008147	TPR motif; other site
111780008148	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780008149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008150	binding surface
111780008151	TPR motif; other site
111780008152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008153	binding surface
111780008154	TPR motif; other site
111780008155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008156	binding surface
111780008157	TPR motif; other site
111780008158	TPR repeat; Region: TPR_11; pfam13414
111780008159	TPR repeat; Region: TPR_11; pfam13414
111780008160	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008161	binding surface
111780008162	TPR motif; other site
111780008163	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780008164	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
111780008165	Probable Catalytic site; other site
111780008166	metal-binding site
111780008167	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
111780008168	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
111780008169	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
111780008170	NAD binding site [chemical binding]; other site
111780008171	substrate binding site [chemical binding]; other site
111780008172	homodimer interface [polypeptide binding]; other site
111780008173	active site
111780008174	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
111780008175	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
111780008176	substrate binding site; other site
111780008177	metal-binding site
111780008178	Oligomer interface; other site
111780008179	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
111780008180	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
111780008181	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
111780008182	NADP binding site [chemical binding]; other site
111780008183	active site
111780008184	putative substrate binding site [chemical binding]; other site
111780008185	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
111780008186	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
111780008187	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
111780008188	putative NADP binding site [chemical binding]; other site
111780008189	putative substrate binding site [chemical binding]; other site
111780008190	active site
111780008191	Right handed beta helix region; Region: Beta_helix; pfam13229
111780008192	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780008193	active site
111780008194	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
111780008195	Domain of unknown function DUF21; Region: DUF21; pfam01595
111780008196	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
111780008197	Transporter associated domain; Region: CorC_HlyC; pfam03471
111780008198	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
111780008199	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
111780008200	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
111780008201	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
111780008202	Uncharacterized conserved protein [Function unknown]; Region: COG1434
111780008203	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
111780008204	putative active site [active]
111780008205	S-layer homology domain; Region: SLH; pfam00395
111780008206	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
111780008207	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
111780008208	tetramer interface [polypeptide binding]; other site
111780008209	dimer interface [polypeptide binding]; other site
111780008210	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
111780008211	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
111780008212	Walker A motif; other site
111780008213	ATP binding site [chemical binding]; other site
111780008214	Walker B motif; other site
111780008215	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
111780008216	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
111780008217	active site
111780008218	homodimer interface [polypeptide binding]; other site
111780008219	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
111780008220	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
111780008221	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
111780008222	active site
111780008223	homodimer interface [polypeptide binding]; other site
111780008224	Predicted methyltransferases [General function prediction only]; Region: COG0313
111780008225	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
111780008226	putative SAM binding site [chemical binding]; other site
111780008227	putative homodimer interface [polypeptide binding]; other site
111780008228	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
111780008229	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
111780008230	substrate binding site [chemical binding]; other site
111780008231	ATP binding site [chemical binding]; other site
111780008232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008233	Response regulator receiver domain; Region: Response_reg; pfam00072
111780008234	active site
111780008235	phosphorylation site [posttranslational modification]
111780008236	intermolecular recognition site; other site
111780008237	dimerization interface [polypeptide binding]; other site
111780008238	Response regulator receiver domain; Region: Response_reg; pfam00072
111780008239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008240	active site
111780008241	phosphorylation site [posttranslational modification]
111780008242	intermolecular recognition site; other site
111780008243	dimerization interface [polypeptide binding]; other site
111780008244	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
111780008245	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008246	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008247	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008248	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008249	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008250	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008251	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008252	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008253	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008254	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008255	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008256	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008257	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
111780008258	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780008259	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780008260	dimer interface [polypeptide binding]; other site
111780008261	putative CheW interface [polypeptide binding]; other site
111780008262	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780008263	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780008264	putative binding surface; other site
111780008265	active site
111780008266	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
111780008267	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780008268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780008269	ATP binding site [chemical binding]; other site
111780008270	Mg2+ binding site [ion binding]; other site
111780008271	G-X-G motif; other site
111780008272	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780008273	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780008274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008275	active site
111780008276	phosphorylation site [posttranslational modification]
111780008277	intermolecular recognition site; other site
111780008278	dimerization interface [polypeptide binding]; other site
111780008279	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008280	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008281	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008282	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008283	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780008284	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780008285	active site
111780008286	ATP binding site [chemical binding]; other site
111780008287	substrate binding site [chemical binding]; other site
111780008288	activation loop (A-loop); other site
111780008289	Uncharacterized conserved protein [Function unknown]; Region: COG1262
111780008290	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
111780008291	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780008292	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
111780008293	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
111780008294	Ligand Binding Site [chemical binding]; other site
111780008295	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
111780008296	active site
111780008297	phosphorylation site [posttranslational modification]
111780008298	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780008299	Ligand Binding Site [chemical binding]; other site
111780008300	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
111780008301	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
111780008302	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
111780008303	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780008304	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
111780008305	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780008306	substrate binding pocket [chemical binding]; other site
111780008307	membrane-bound complex binding site; other site
111780008308	hinge residues; other site
111780008309	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
111780008310	Peptidase family M50; Region: Peptidase_M50; pfam02163
111780008311	active site
111780008312	putative substrate binding region [chemical binding]; other site
111780008313	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780008314	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
111780008315	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
111780008316	dihydropteroate synthase; Region: DHPS; TIGR01496
111780008317	substrate binding pocket [chemical binding]; other site
111780008318	dimer interface [polypeptide binding]; other site
111780008319	inhibitor binding site; inhibition site
111780008320	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
111780008321	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
111780008322	phosphoglyceromutase; Provisional; Region: PRK05434
111780008323	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
111780008324	Cache domain; Region: Cache_1; pfam02743
111780008325	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780008326	dimerization interface [polypeptide binding]; other site
111780008327	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780008328	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780008329	dimer interface [polypeptide binding]; other site
111780008330	putative CheW interface [polypeptide binding]; other site
111780008331	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780008332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008333	active site
111780008334	phosphorylation site [posttranslational modification]
111780008335	intermolecular recognition site; other site
111780008336	dimerization interface [polypeptide binding]; other site
111780008337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780008338	DNA binding site [nucleotide binding]
111780008339	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
111780008340	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
111780008341	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
111780008342	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
111780008343	Transcriptional regulator [Transcription]; Region: LysR; COG0583
111780008344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780008345	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
111780008346	putative dimerization interface [polypeptide binding]; other site
111780008347	Predicted membrane protein [Function unknown]; Region: COG3431
111780008348	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
111780008349	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
111780008350	active site residue [active]
111780008351	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
111780008352	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
111780008353	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780008354	active site
111780008355	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
111780008356	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780008357	active site
111780008358	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
111780008359	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
111780008360	putative active site [active]
111780008361	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
111780008362	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
111780008363	Walker A/P-loop; other site
111780008364	ATP binding site [chemical binding]; other site
111780008365	Q-loop/lid; other site
111780008366	ABC transporter signature motif; other site
111780008367	Walker B; other site
111780008368	D-loop; other site
111780008369	H-loop/switch region; other site
111780008370	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
111780008371	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
111780008372	Walker A/P-loop; other site
111780008373	ATP binding site [chemical binding]; other site
111780008374	Q-loop/lid; other site
111780008375	ABC transporter signature motif; other site
111780008376	Walker B; other site
111780008377	D-loop; other site
111780008378	H-loop/switch region; other site
111780008379	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
111780008380	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
111780008381	AAA domain; Region: AAA_17; pfam13207
111780008382	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
111780008383	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
111780008384	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
111780008385	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
111780008386	O-Antigen ligase; Region: Wzy_C; pfam04932
111780008387	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
111780008388	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
111780008389	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
111780008390	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
111780008391	RuvA N terminal domain; Region: RuvA_N; pfam01330
111780008392	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
111780008393	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
111780008394	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
111780008395	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
111780008396	active site
111780008397	motif I; other site
111780008398	motif II; other site
111780008399	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
111780008400	putative hexamer interface [polypeptide binding]; other site
111780008401	putative hexagonal pore; other site
111780008402	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
111780008403	Hexamer interface [polypeptide binding]; other site
111780008404	Hexagonal pore residue; other site
111780008405	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780008406	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008407	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008408	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780008409	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008410	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008411	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780008412	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008413	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780008414	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008415	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
111780008416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780008417	active site
111780008418	motif I; other site
111780008419	motif II; other site
111780008420	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
111780008421	WAHD domain of WASH complex; Region: WASH_WAHD; pfam11945
111780008422	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
111780008423	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
111780008424	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
111780008425	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780008426	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
111780008427	NAD binding site [chemical binding]; other site
111780008428	putative substrate binding site 2 [chemical binding]; other site
111780008429	putative substrate binding site 1 [chemical binding]; other site
111780008430	active site
111780008431	FO synthase subunit 2; Reviewed; Region: PRK07360
111780008432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780008433	FeS/SAM binding site; other site
111780008434	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
111780008435	active site
111780008436	GIY-YIG motif/motif A; other site
111780008437	catalytic site [active]
111780008438	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
111780008439	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
111780008440	substrate binding site [chemical binding]; other site
111780008441	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
111780008442	substrate binding site [chemical binding]; other site
111780008443	ligand binding site [chemical binding]; other site
111780008444	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
111780008445	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
111780008446	ATP-grasp domain; Region: ATP-grasp_4; cl17255
111780008447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780008448	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780008449	Probable transposase; Region: OrfB_IS605; pfam01385
111780008450	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780008451	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
111780008452	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780008453	Inward rectifier potassium channel; Region: IRK; pfam01007
111780008454	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
111780008455	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
111780008456	C-terminal domain interface [polypeptide binding]; other site
111780008457	GSH binding site (G-site) [chemical binding]; other site
111780008458	dimer interface [polypeptide binding]; other site
111780008459	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
111780008460	N-terminal domain interface [polypeptide binding]; other site
111780008461	putative dimer interface [polypeptide binding]; other site
111780008462	active site
111780008463	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780008464	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780008465	catalytic loop [active]
111780008466	iron binding site [ion binding]; other site
111780008467	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
111780008468	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
111780008469	recombinase A; Provisional; Region: recA; PRK09354
111780008470	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
111780008471	hexamer interface [polypeptide binding]; other site
111780008472	Walker A motif; other site
111780008473	ATP binding site [chemical binding]; other site
111780008474	Walker B motif; other site
111780008475	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
111780008476	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
111780008477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
111780008478	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780008479	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008480	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008481	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008482	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008483	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008484	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780008485	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008486	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
111780008487	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
111780008488	substrate binding site [chemical binding]; other site
111780008489	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
111780008490	Cadmium resistance transporter; Region: Cad; pfam03596
111780008491	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
111780008492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780008493	NAD(P) binding site [chemical binding]; other site
111780008494	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
111780008495	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
111780008496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780008497	active site
111780008498	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780008499	CpeS-like protein; Region: CpeS; pfam09367
111780008500	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
111780008501	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
111780008502	MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299
111780008503	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780008504	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
111780008505	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
111780008506	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
111780008507	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
111780008508	putative active site [active]
111780008509	catalytic site [active]
111780008510	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
111780008511	putative ligand binding site [chemical binding]; other site
111780008512	adhesin; Provisional; Region: PRK09752
111780008513	adhesin; Provisional; Region: PRK09752
111780008514	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
111780008515	Peptidase family M48; Region: Peptidase_M48; pfam01435
111780008516	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780008517	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780008518	Probable transposase; Region: OrfB_IS605; pfam01385
111780008519	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780008520	Bacterial SH3 domain homologues; Region: SH3b; smart00287
111780008521	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
111780008522	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283
111780008523	nad+ binding pocket [chemical binding]; other site
111780008524	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
111780008525	oligomeric interface; other site
111780008526	putative active site [active]
111780008527	homodimer interface [polypeptide binding]; other site
111780008528	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780008529	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780008530	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780008531	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780008532	TPR repeat; Region: TPR_11; pfam13414
111780008533	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008534	binding surface
111780008535	TPR motif; other site
111780008536	TPR repeat; Region: TPR_11; pfam13414
111780008537	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780008538	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780008539	active site
111780008540	ATP binding site [chemical binding]; other site
111780008541	substrate binding site [chemical binding]; other site
111780008542	activation loop (A-loop); other site
111780008543	Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329
111780008544	aromatic arch; other site
111780008545	DCoH dimer interaction site [polypeptide binding]; other site
111780008546	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
111780008547	DCoH tetramer interaction site [polypeptide binding]; other site
111780008548	substrate binding site [chemical binding]; other site
111780008549	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
111780008550	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
111780008551	FMN binding site [chemical binding]; other site
111780008552	active site
111780008553	catalytic residues [active]
111780008554	substrate binding site [chemical binding]; other site
111780008555	SOS regulatory protein LexA; Region: lexA; TIGR00498
111780008556	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
111780008557	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
111780008558	Catalytic site [active]
111780008559	acetyl-CoA synthetase; Provisional; Region: PRK00174
111780008560	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
111780008561	active site
111780008562	CoA binding site [chemical binding]; other site
111780008563	acyl-activating enzyme (AAE) consensus motif; other site
111780008564	AMP binding site [chemical binding]; other site
111780008565	acetate binding site [chemical binding]; other site
111780008566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
111780008567	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
111780008568	DNA methylase; Region: N6_N4_Mtase; pfam01555
111780008569	Restriction endonuclease; Region: Mrr_cat; pfam04471
111780008570	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
111780008571	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
111780008572	active site
111780008573	Zn binding site [ion binding]; other site
111780008574	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780008575	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780008576	catalytic loop [active]
111780008577	iron binding site [ion binding]; other site
111780008578	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
111780008579	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
111780008580	putative substrate binding pocket [chemical binding]; other site
111780008581	AC domain interface; other site
111780008582	catalytic triad [active]
111780008583	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
111780008584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780008585	Walker B motif; other site
111780008586	arginine finger; other site
111780008587	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
111780008588	metal ion-dependent adhesion site (MIDAS); other site
111780008589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780008590	Probable transposase; Region: OrfB_IS605; pfam01385
111780008591	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780008592	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
111780008593	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
111780008594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780008595	motif II; other site
111780008596	transketolase; Reviewed; Region: PRK05899
111780008597	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
111780008598	TPP-binding site [chemical binding]; other site
111780008599	dimer interface [polypeptide binding]; other site
111780008600	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
111780008601	PYR/PP interface [polypeptide binding]; other site
111780008602	dimer interface [polypeptide binding]; other site
111780008603	TPP binding site [chemical binding]; other site
111780008604	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
111780008605	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
111780008606	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
111780008607	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008608	GAF domain; Region: GAF; pfam01590
111780008609	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
111780008610	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
111780008611	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
111780008612	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
111780008613	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
111780008614	metal-binding site [ion binding]
111780008615	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780008616	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780008617	motif II; other site
111780008618	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780008619	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780008620	phosphopeptide binding site; other site
111780008621	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
111780008622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780008623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780008624	homodimer interface [polypeptide binding]; other site
111780008625	catalytic residue [active]
111780008626	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
111780008627	DNA protecting protein DprA; Region: dprA; TIGR00732
111780008628	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
111780008629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780008630	S-adenosylmethionine binding site [chemical binding]; other site
111780008631	Ycf46; Provisional; Region: ycf46; CHL00195
111780008632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780008633	Walker A motif; other site
111780008634	ATP binding site [chemical binding]; other site
111780008635	Walker B motif; other site
111780008636	arginine finger; other site
111780008637	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
111780008638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780008639	NAD(P) binding site [chemical binding]; other site
111780008640	active site
111780008641	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
111780008642	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
111780008643	putative acyl-acceptor binding pocket; other site
111780008644	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
111780008645	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
111780008646	active site
111780008647	Riboflavin kinase; Region: Flavokinase; pfam01687
111780008648	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
111780008649	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780008650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008651	active site
111780008652	phosphorylation site [posttranslational modification]
111780008653	intermolecular recognition site; other site
111780008654	dimerization interface [polypeptide binding]; other site
111780008655	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780008656	metal binding site [ion binding]; metal-binding site
111780008657	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
111780008658	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780008659	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
111780008660	Uncharacterized conserved protein [Function unknown]; Region: COG0398
111780008661	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
111780008662	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780008663	Domain of unknown function DUF20; Region: UPF0118; pfam01594
111780008664	Domain of unknown function DUF39; Region: DUF39; pfam01837
111780008665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008666	binding surface
111780008667	TPR motif; other site
111780008668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780008669	TPR motif; other site
111780008670	TPR repeat; Region: TPR_11; pfam13414
111780008671	binding surface
111780008672	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
111780008673	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
111780008674	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
111780008675	alpha subunit interaction interface [polypeptide binding]; other site
111780008676	Walker A motif; other site
111780008677	ATP binding site [chemical binding]; other site
111780008678	Walker B motif; other site
111780008679	inhibitor binding site; inhibition site
111780008680	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
111780008681	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
111780008682	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
111780008683	gamma subunit interface [polypeptide binding]; other site
111780008684	epsilon subunit interface [polypeptide binding]; other site
111780008685	LBP interface [polypeptide binding]; other site
111780008686	hypothetical protein; Provisional; Region: PRK02724
111780008687	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
111780008688	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
111780008689	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
111780008690	active site
111780008691	8-oxo-dGMP binding site [chemical binding]; other site
111780008692	nudix motif; other site
111780008693	metal binding site [ion binding]; metal-binding site
111780008694	Protein of unknown function (DUF760); Region: DUF760; pfam05542
111780008695	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
111780008696	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
111780008697	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780008698	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780008699	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780008700	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780008701	DNA binding residues [nucleotide binding]
111780008702	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
111780008703	catalytic core [active]
111780008704	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
111780008705	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
111780008706	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780008707	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780008708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780008709	DNA binding residues [nucleotide binding]
111780008710	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
111780008711	glucose-1-dehydrogenase; Provisional; Region: PRK08936
111780008712	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
111780008713	NAD binding site [chemical binding]; other site
111780008714	homodimer interface [polypeptide binding]; other site
111780008715	active site
111780008716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008717	active site
111780008718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780008719	phosphorylation site [posttranslational modification]
111780008720	intermolecular recognition site; other site
111780008721	dimerization interface [polypeptide binding]; other site
111780008722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780008723	ATP binding site [chemical binding]; other site
111780008724	Mg2+ binding site [ion binding]; other site
111780008725	G-X-G motif; other site
111780008726	Response regulator receiver domain; Region: Response_reg; pfam00072
111780008727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008728	active site
111780008729	phosphorylation site [posttranslational modification]
111780008730	intermolecular recognition site; other site
111780008731	dimerization interface [polypeptide binding]; other site
111780008732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780008733	dimer interface [polypeptide binding]; other site
111780008734	phosphorylation site [posttranslational modification]
111780008735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780008736	ATP binding site [chemical binding]; other site
111780008737	Mg2+ binding site [ion binding]; other site
111780008738	G-X-G motif; other site
111780008739	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780008740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008741	active site
111780008742	phosphorylation site [posttranslational modification]
111780008743	intermolecular recognition site; other site
111780008744	dimerization interface [polypeptide binding]; other site
111780008745	PAS fold; Region: PAS; pfam00989
111780008746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780008747	putative active site [active]
111780008748	heme pocket [chemical binding]; other site
111780008749	PAS domain S-box; Region: sensory_box; TIGR00229
111780008750	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780008751	putative active site [active]
111780008752	heme pocket [chemical binding]; other site
111780008753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780008754	PAS domain; Region: PAS_9; pfam13426
111780008755	putative active site [active]
111780008756	heme pocket [chemical binding]; other site
111780008757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780008758	PAS fold; Region: PAS_3; pfam08447
111780008759	putative active site [active]
111780008760	heme pocket [chemical binding]; other site
111780008761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780008762	dimer interface [polypeptide binding]; other site
111780008763	phosphorylation site [posttranslational modification]
111780008764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780008765	ATP binding site [chemical binding]; other site
111780008766	Mg2+ binding site [ion binding]; other site
111780008767	G-X-G motif; other site
111780008768	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780008769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008770	active site
111780008771	phosphorylation site [posttranslational modification]
111780008772	intermolecular recognition site; other site
111780008773	dimerization interface [polypeptide binding]; other site
111780008774	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780008775	DNA binding residues [nucleotide binding]
111780008776	dimerization interface [polypeptide binding]; other site
111780008777	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
111780008778	Response regulator receiver domain; Region: Response_reg; pfam00072
111780008779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008780	active site
111780008781	phosphorylation site [posttranslational modification]
111780008782	intermolecular recognition site; other site
111780008783	dimerization interface [polypeptide binding]; other site
111780008784	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
111780008785	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
111780008786	Phycobilisome protein; Region: Phycobilisome; cl08227
111780008787	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
111780008788	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780008789	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780008790	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
111780008791	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780008792	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
111780008793	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
111780008794	PAS domain S-box; Region: sensory_box; TIGR00229
111780008795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780008796	putative active site [active]
111780008797	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008798	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008799	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
111780008800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
111780008801	putative active site [active]
111780008802	heme pocket [chemical binding]; other site
111780008803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780008804	dimer interface [polypeptide binding]; other site
111780008805	phosphorylation site [posttranslational modification]
111780008806	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780008807	ATP binding site [chemical binding]; other site
111780008808	Mg2+ binding site [ion binding]; other site
111780008809	G-X-G motif; other site
111780008810	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780008811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008812	active site
111780008813	phosphorylation site [posttranslational modification]
111780008814	intermolecular recognition site; other site
111780008815	dimerization interface [polypeptide binding]; other site
111780008816	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780008817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008818	active site
111780008819	phosphorylation site [posttranslational modification]
111780008820	intermolecular recognition site; other site
111780008821	dimerization interface [polypeptide binding]; other site
111780008822	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780008823	DNA binding site [nucleotide binding]
111780008824	Hpt domain; Region: Hpt; pfam01627
111780008825	putative binding surface; other site
111780008826	active site
111780008827	Response regulator receiver domain; Region: Response_reg; pfam00072
111780008828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008829	active site
111780008830	phosphorylation site [posttranslational modification]
111780008831	intermolecular recognition site; other site
111780008832	dimerization interface [polypeptide binding]; other site
111780008833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780008834	Response regulator receiver domain; Region: Response_reg; pfam00072
111780008835	active site
111780008836	phosphorylation site [posttranslational modification]
111780008837	intermolecular recognition site; other site
111780008838	dimerization interface [polypeptide binding]; other site
111780008839	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
111780008840	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
111780008841	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
111780008842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780008843	catalytic residue [active]
111780008844	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
111780008845	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
111780008846	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
111780008847	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
111780008848	catalytic site [active]
111780008849	putative active site [active]
111780008850	putative substrate binding site [chemical binding]; other site
111780008851	HPP family; Region: HPP; pfam04982
111780008852	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
111780008853	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
111780008854	acyl-CoA synthetase; Validated; Region: PRK05850
111780008855	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
111780008856	acyl-activating enzyme (AAE) consensus motif; other site
111780008857	active site
111780008858	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
111780008859	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
111780008860	active site
111780008861	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
111780008862	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
111780008863	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
111780008864	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
111780008865	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780008866	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
111780008867	Protein of unknown function, DUF393; Region: DUF393; pfam04134
111780008868	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
111780008869	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
111780008870	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
111780008871	DNA photolyase; Region: DNA_photolyase; pfam00875
111780008872	Protein of unknown function (DUF938); Region: DUF938; pfam06080
111780008873	urease subunit alpha; Reviewed; Region: ureC; PRK13207
111780008874	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
111780008875	subunit interactions [polypeptide binding]; other site
111780008876	active site
111780008877	flap region; other site
111780008878	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
111780008879	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
111780008880	Predicted transcriptional regulators [Transcription]; Region: COG1733
111780008881	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
111780008882	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780008883	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
111780008884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780008885	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
111780008886	Haemolysin XhlA; Region: XhlA; pfam10779
111780008887	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
111780008888	HflK protein; Region: hflK; TIGR01933
111780008889	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
111780008890	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
111780008891	DNA binding residues [nucleotide binding]
111780008892	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
111780008893	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
111780008894	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
111780008895	Trehalase; Region: Trehalase; cl17346
111780008896	ferredoxin-sulfite reductase; Region: sir; TIGR02042
111780008897	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
111780008898	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
111780008899	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
111780008900	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
111780008901	CoA binding domain; Region: CoA_binding; smart00881
111780008902	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
111780008903	ABC-2 type transporter; Region: ABC2_membrane; cl17235
111780008904	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
111780008905	Protein of unknown function (DUF760); Region: DUF760; pfam05542
111780008906	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
111780008907	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
111780008908	dimer interface [polypeptide binding]; other site
111780008909	substrate binding site [chemical binding]; other site
111780008910	ATP binding site [chemical binding]; other site
111780008911	cell division protein FtsZ; Validated; Region: PRK09330
111780008912	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
111780008913	nucleotide binding site [chemical binding]; other site
111780008914	SulA interaction site; other site
111780008915	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
111780008916	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
111780008917	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
111780008918	C-terminal peptidase (prc); Region: prc; TIGR00225
111780008919	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
111780008920	protein binding site [polypeptide binding]; other site
111780008921	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
111780008922	Catalytic dyad [active]
111780008923	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
111780008924	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
111780008925	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
111780008926	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
111780008927	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
111780008928	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
111780008929	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
111780008930	putative active site [active]
111780008931	transaldolase; Provisional; Region: PRK03903
111780008932	catalytic residue [active]
111780008933	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
111780008934	AMP binding site [chemical binding]; other site
111780008935	metal binding site [ion binding]; metal-binding site
111780008936	active site
111780008937	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
111780008938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780008939	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
111780008940	G1 box; other site
111780008941	GTP/Mg2+ binding site [chemical binding]; other site
111780008942	G2 box; other site
111780008943	Switch I region; other site
111780008944	G3 box; other site
111780008945	Switch II region; other site
111780008946	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
111780008947	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
111780008948	Aluminium resistance protein; Region: Alum_res; pfam06838
111780008949	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
111780008950	Fatty acid desaturase; Region: FA_desaturase; pfam00487
111780008951	Di-iron ligands [ion binding]; other site
111780008952	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
111780008953	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
111780008954	putative acyl-acceptor binding pocket; other site
111780008955	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
111780008956	active site
111780008957	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
111780008958	homodimer interface [polypeptide binding]; other site
111780008959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780008960	catalytic residue [active]
111780008961	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
111780008962	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
111780008963	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
111780008964	Phycobilisome protein; Region: Phycobilisome; cl08227
111780008965	HEAT repeats; Region: HEAT_2; pfam13646
111780008966	HEAT repeats; Region: HEAT_2; pfam13646
111780008967	CpeS-like protein; Region: CpeS; pfam09367
111780008968	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780008969	Predicted permease [General function prediction only]; Region: COG3329
111780008970	Repair protein; Region: Repair_PSII; pfam04536
111780008971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
111780008972	MORN repeat; Region: MORN; cl14787
111780008973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
111780008974	MORN repeat; Region: MORN; cl14787
111780008975	MORN repeat; Region: MORN; cl14787
111780008976	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
111780008977	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
111780008978	cell division protein; Validated; Region: ftsH; CHL00176
111780008979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780008980	Walker A motif; other site
111780008981	ATP binding site [chemical binding]; other site
111780008982	Walker B motif; other site
111780008983	arginine finger; other site
111780008984	Peptidase family M41; Region: Peptidase_M41; pfam01434
111780008985	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
111780008986	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008987	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780008988	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008989	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780008990	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
111780008991	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780008992	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780008993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780008994	dimer interface [polypeptide binding]; other site
111780008995	phosphorylation site [posttranslational modification]
111780008996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780008997	ATP binding site [chemical binding]; other site
111780008998	Mg2+ binding site [ion binding]; other site
111780008999	G-X-G motif; other site
111780009000	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
111780009001	active site
111780009002	dimerization interface [polypeptide binding]; other site
111780009003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
111780009004	dimerization interface [polypeptide binding]; other site
111780009005	putative DNA binding site [nucleotide binding]; other site
111780009006	putative Zn2+ binding site [ion binding]; other site
111780009007	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
111780009008	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
111780009009	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
111780009010	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780009011	ATP binding site [chemical binding]; other site
111780009012	putative Mg++ binding site [ion binding]; other site
111780009013	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780009014	nucleotide binding region [chemical binding]; other site
111780009015	ATP-binding site [chemical binding]; other site
111780009016	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
111780009017	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780009018	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780009019	active site
111780009020	ATP binding site [chemical binding]; other site
111780009021	substrate binding site [chemical binding]; other site
111780009022	activation loop (A-loop); other site
111780009023	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
111780009024	DDE superfamily endonuclease; Region: DDE_5; cl17874
111780009025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780009026	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
111780009027	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780009028	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780009029	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780009030	DNA binding residues [nucleotide binding]
111780009031	dimerization interface [polypeptide binding]; other site
111780009032	Response regulator receiver domain; Region: Response_reg; pfam00072
111780009033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009034	active site
111780009035	phosphorylation site [posttranslational modification]
111780009036	intermolecular recognition site; other site
111780009037	dimerization interface [polypeptide binding]; other site
111780009038	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780009039	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780009040	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780009041	PAS fold; Region: PAS_3; pfam08447
111780009042	putative active site [active]
111780009043	heme pocket [chemical binding]; other site
111780009044	PAS fold; Region: PAS_4; pfam08448
111780009045	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780009046	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
111780009047	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780009048	putative active site [active]
111780009049	heme pocket [chemical binding]; other site
111780009050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780009051	putative active site [active]
111780009052	heme pocket [chemical binding]; other site
111780009053	PAS domain S-box; Region: sensory_box; TIGR00229
111780009054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780009055	putative active site [active]
111780009056	heme pocket [chemical binding]; other site
111780009057	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780009058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780009059	dimer interface [polypeptide binding]; other site
111780009060	phosphorylation site [posttranslational modification]
111780009061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780009062	ATP binding site [chemical binding]; other site
111780009063	Mg2+ binding site [ion binding]; other site
111780009064	G-X-G motif; other site
111780009065	Response regulator receiver domain; Region: Response_reg; pfam00072
111780009066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009067	active site
111780009068	phosphorylation site [posttranslational modification]
111780009069	intermolecular recognition site; other site
111780009070	dimerization interface [polypeptide binding]; other site
111780009071	GTP-binding protein Der; Reviewed; Region: PRK00093
111780009072	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
111780009073	G1 box; other site
111780009074	GTP/Mg2+ binding site [chemical binding]; other site
111780009075	Switch I region; other site
111780009076	G2 box; other site
111780009077	Switch II region; other site
111780009078	G3 box; other site
111780009079	G4 box; other site
111780009080	G5 box; other site
111780009081	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
111780009082	G1 box; other site
111780009083	GTP/Mg2+ binding site [chemical binding]; other site
111780009084	Switch I region; other site
111780009085	G2 box; other site
111780009086	G3 box; other site
111780009087	Switch II region; other site
111780009088	G4 box; other site
111780009089	G5 box; other site
111780009090	L-asparaginase II; Region: Asparaginase_II; cl01842
111780009091	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
111780009092	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
111780009093	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
111780009094	Zn2+ binding site [ion binding]; other site
111780009095	Mg2+ binding site [ion binding]; other site
111780009096	putative glycosyl transferase; Provisional; Region: PRK10307
111780009097	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
111780009098	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
111780009099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780009100	ATP binding site [chemical binding]; other site
111780009101	Mg2+ binding site [ion binding]; other site
111780009102	G-X-G motif; other site
111780009103	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
111780009104	anti sigma factor interaction site; other site
111780009105	regulatory phosphorylation site [posttranslational modification]; other site
111780009106	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
111780009107	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780009108	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
111780009109	Bacitracin resistance protein BacA; Region: BacA; pfam02673
111780009110	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
111780009111	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
111780009112	Protein of unknown function (DUF512); Region: DUF512; pfam04459
111780009113	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
111780009114	BioY family; Region: BioY; pfam02632
111780009115	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780009116	HSP70 interaction site [polypeptide binding]; other site
111780009117	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780009118	TPR repeat; Region: TPR_11; pfam13414
111780009119	binding surface
111780009120	TPR motif; other site
111780009121	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
111780009122	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
111780009123	dimer interface [polypeptide binding]; other site
111780009124	motif 1; other site
111780009125	active site
111780009126	motif 2; other site
111780009127	motif 3; other site
111780009128	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780009129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009130	active site
111780009131	phosphorylation site [posttranslational modification]
111780009132	intermolecular recognition site; other site
111780009133	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
111780009134	ABC1 family; Region: ABC1; pfam03109
111780009135	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
111780009136	active site
111780009137	ATP binding site [chemical binding]; other site
111780009138	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
111780009139	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
111780009140	active site
111780009141	catalytic residues [active]
111780009142	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
111780009143	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780009144	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780009145	phosphopeptide binding site; other site
111780009146	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780009147	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780009148	active site
111780009149	ATP binding site [chemical binding]; other site
111780009150	substrate binding site [chemical binding]; other site
111780009151	activation loop (A-loop); other site
111780009152	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
111780009153	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
111780009154	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
111780009155	active site
111780009156	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
111780009157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780009158	NAD(P) binding site [chemical binding]; other site
111780009159	active site
111780009160	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
111780009161	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
111780009162	NADH(P)-binding; Region: NAD_binding_10; pfam13460
111780009163	NAD(P) binding site [chemical binding]; other site
111780009164	putative active site [active]
111780009165	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
111780009166	N-acetyl-D-glucosamine binding site [chemical binding]; other site
111780009167	catalytic residue [active]
111780009168	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780009169	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009170	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780009171	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009172	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009173	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009174	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
111780009175	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
111780009176	inhibitor-cofactor binding pocket; inhibition site
111780009177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780009178	catalytic residue [active]
111780009179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
111780009180	Predicted kinase [General function prediction only]; Region: COG0645
111780009181	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
111780009182	ATP-binding site [chemical binding]; other site
111780009183	Gluconate-6-phosphate binding site [chemical binding]; other site
111780009184	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780009185	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
111780009186	putative NAD(P) binding site [chemical binding]; other site
111780009187	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
111780009188	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
111780009189	Recombinase; Region: Recombinase; pfam07508
111780009190	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
111780009191	Yqey-like protein; Region: YqeY; pfam09424
111780009192	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
111780009193	putative active site [active]
111780009194	catalytic residue [active]
111780009195	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
111780009196	Uncharacterized conserved protein [Function unknown]; Region: COG0062
111780009197	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
111780009198	putative substrate binding site [chemical binding]; other site
111780009199	putative ATP binding site [chemical binding]; other site
111780009200	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
111780009201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780009202	Walker A/P-loop; other site
111780009203	ATP binding site [chemical binding]; other site
111780009204	Q-loop/lid; other site
111780009205	ABC transporter signature motif; other site
111780009206	Walker B; other site
111780009207	D-loop; other site
111780009208	H-loop/switch region; other site
111780009209	TOBE domain; Region: TOBE_2; pfam08402
111780009210	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
111780009211	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
111780009212	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
111780009213	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780009214	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
111780009215	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780009216	putative cation:proton antiport protein; Provisional; Region: PRK10669
111780009217	TrkA-N domain; Region: TrkA_N; pfam02254
111780009218	TrkA-C domain; Region: TrkA_C; pfam02080
111780009219	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780009220	HSP70 interaction site [polypeptide binding]; other site
111780009221	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
111780009222	HicB family; Region: HicB; pfam05534
111780009223	Ycf46; Provisional; Region: ycf46; CHL00195
111780009224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780009225	Walker A motif; other site
111780009226	ATP binding site [chemical binding]; other site
111780009227	Walker B motif; other site
111780009228	arginine finger; other site
111780009229	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
111780009230	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780009231	active site
111780009232	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780009233	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780009234	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780009235	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780009236	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
111780009237	Walker A/P-loop; other site
111780009238	ATP binding site [chemical binding]; other site
111780009239	Q-loop/lid; other site
111780009240	ABC transporter signature motif; other site
111780009241	Walker B; other site
111780009242	D-loop; other site
111780009243	H-loop/switch region; other site
111780009244	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780009245	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
111780009246	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
111780009247	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
111780009248	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
111780009249	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
111780009250	HEAT repeats; Region: HEAT_2; pfam13646
111780009251	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
111780009252	gamma-glutamyl kinase; Provisional; Region: PRK05429
111780009253	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
111780009254	nucleotide binding site [chemical binding]; other site
111780009255	homotetrameric interface [polypeptide binding]; other site
111780009256	putative phosphate binding site [ion binding]; other site
111780009257	putative allosteric binding site; other site
111780009258	PUA domain; Region: PUA; pfam01472
111780009259	Peptidase family M41; Region: Peptidase_M41; pfam01434
111780009260	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
111780009261	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
111780009262	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
111780009263	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
111780009264	protein I interface; other site
111780009265	D2 interface; other site
111780009266	protein T interface; other site
111780009267	chlorophyll binding site; other site
111780009268	beta carotene binding site; other site
111780009269	pheophytin binding site; other site
111780009270	manganese-stabilizing polypeptide interface; other site
111780009271	CP43 interface; other site
111780009272	protein L interface; other site
111780009273	oxygen evolving complex binding site; other site
111780009274	bromide binding site; other site
111780009275	quinone binding site; other site
111780009276	Fe binding site [ion binding]; other site
111780009277	core light harvesting interface; other site
111780009278	cytochrome b559 alpha subunit interface; other site
111780009279	cytochrome c-550 interface; other site
111780009280	protein J interface; other site
111780009281	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780009282	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780009283	active site
111780009284	catalytic tetrad [active]
111780009285	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
111780009286	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
111780009287	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
111780009288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
111780009289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780009290	S-adenosylmethionine binding site [chemical binding]; other site
111780009291	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
111780009292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780009293	motif II; other site
111780009294	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
111780009295	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
111780009296	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
111780009297	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
111780009298	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
111780009299	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
111780009300	Ligand Binding Site [chemical binding]; other site
111780009301	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
111780009302	Response regulator receiver domain; Region: Response_reg; pfam00072
111780009303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009304	active site
111780009305	phosphorylation site [posttranslational modification]
111780009306	intermolecular recognition site; other site
111780009307	dimerization interface [polypeptide binding]; other site
111780009308	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
111780009309	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780009310	ATP binding site [chemical binding]; other site
111780009311	putative Mg++ binding site [ion binding]; other site
111780009312	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780009313	nucleotide binding region [chemical binding]; other site
111780009314	ATP-binding site [chemical binding]; other site
111780009315	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780009316	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780009317	phosphopeptide binding site; other site
111780009318	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
111780009319	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
111780009320	FAD binding pocket [chemical binding]; other site
111780009321	FAD binding motif [chemical binding]; other site
111780009322	phosphate binding motif [ion binding]; other site
111780009323	beta-alpha-beta structure motif; other site
111780009324	NAD binding pocket [chemical binding]; other site
111780009325	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780009326	catalytic loop [active]
111780009327	iron binding site [ion binding]; other site
111780009328	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
111780009329	MoaE homodimer interface [polypeptide binding]; other site
111780009330	MoaD interaction [polypeptide binding]; other site
111780009331	active site residues [active]
111780009332	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
111780009333	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
111780009334	Permease; Region: Permease; cl00510
111780009335	amidophosphoribosyltransferase; Provisional; Region: PRK07349
111780009336	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
111780009337	active site
111780009338	tetramer interface [polypeptide binding]; other site
111780009339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780009340	active site
111780009341	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
111780009342	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
111780009343	dimerization interface [polypeptide binding]; other site
111780009344	ATP binding site [chemical binding]; other site
111780009345	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
111780009346	dimerization interface [polypeptide binding]; other site
111780009347	ATP binding site [chemical binding]; other site
111780009348	Protein of unknown function (DUF497); Region: DUF497; pfam04365
111780009349	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780009350	putative active site [active]
111780009351	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
111780009352	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
111780009353	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
111780009354	trimer interface [polypeptide binding]; other site
111780009355	active site
111780009356	UDP-GlcNAc binding site [chemical binding]; other site
111780009357	lipid binding site [chemical binding]; lipid-binding site
111780009358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780009359	S-adenosylmethionine binding site [chemical binding]; other site
111780009360	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
111780009361	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
111780009362	Ligand Binding Site [chemical binding]; other site
111780009363	TIGR00269 family protein; Region: TIGR00269
111780009364	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
111780009365	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
111780009366	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780009367	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
111780009368	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
111780009369	dimer interface [polypeptide binding]; other site
111780009370	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
111780009371	active site
111780009372	Fe binding site [ion binding]; other site
111780009373	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780009374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780009375	S-adenosylmethionine binding site [chemical binding]; other site
111780009376	lipoyl synthase; Provisional; Region: PRK05481
111780009377	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
111780009378	FeS/SAM binding site; other site
111780009379	D5 N terminal like; Region: D5_N; smart00885
111780009380	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
111780009381	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780009382	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780009383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780009384	S-adenosylmethionine binding site [chemical binding]; other site
111780009385	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780009386	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
111780009387	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780009388	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
111780009389	metal-binding site
111780009390	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780009391	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
111780009392	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780009393	Methyltransferase domain; Region: Methyltransf_12; pfam08242
111780009394	GNT-I family; Region: GNT-I; pfam03071
111780009395	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780009396	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
111780009397	Probable transposase; Region: OrfB_IS605; pfam01385
111780009398	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780009399	Uncharacterized conserved protein [Function unknown]; Region: COG3791
111780009400	Predicted membrane protein [Function unknown]; Region: COG4270
111780009401	UV-endonuclease UvdE; Region: UvdE; cl10036
111780009402	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
111780009403	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
111780009404	NADH(P)-binding; Region: NAD_binding_10; pfam13460
111780009405	NAD(P) binding site [chemical binding]; other site
111780009406	putative active site [active]
111780009407	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
111780009408	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
111780009409	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
111780009410	active site
111780009411	substrate binding site [chemical binding]; other site
111780009412	Mg2+ binding site [ion binding]; other site
111780009413	Haemolytic domain; Region: Haemolytic; cl00506
111780009414	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
111780009415	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873
111780009416	metal binding site [ion binding]; metal-binding site
111780009417	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
111780009418	Mechanosensitive ion channel; Region: MS_channel; pfam00924
111780009419	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
111780009420	ATP-NAD kinase; Region: NAD_kinase; pfam01513
111780009421	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780009422	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
111780009423	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
111780009424	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
111780009425	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
111780009426	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
111780009427	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
111780009428	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
111780009429	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
111780009430	N- and C-terminal domain interface [polypeptide binding]; other site
111780009431	active site
111780009432	MgATP binding site [chemical binding]; other site
111780009433	catalytic site [active]
111780009434	metal binding site [ion binding]; metal-binding site
111780009435	glycerol binding site [chemical binding]; other site
111780009436	homotetramer interface [polypeptide binding]; other site
111780009437	homodimer interface [polypeptide binding]; other site
111780009438	FBP binding site [chemical binding]; other site
111780009439	protein IIAGlc interface [polypeptide binding]; other site
111780009440	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
111780009441	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
111780009442	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
111780009443	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
111780009444	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
111780009445	homodimer interface [polypeptide binding]; other site
111780009446	Walker A motif; other site
111780009447	ATP binding site [chemical binding]; other site
111780009448	hydroxycobalamin binding site [chemical binding]; other site
111780009449	Walker B motif; other site
111780009450	CsbD-like; Region: CsbD; pfam05532
111780009451	heat shock protein HtpX; Provisional; Region: PRK03982
111780009452	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
111780009453	putative lipid kinase; Reviewed; Region: PRK13057
111780009454	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
111780009455	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
111780009456	catalytic residue [active]
111780009457	putative FPP diphosphate  binding site; other site
111780009458	putative FPP binding hydrophobic cleft; other site
111780009459	dimer interface [polypeptide binding]; other site
111780009460	putative IPP diphosphate binding site; other site
111780009461	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
111780009462	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
111780009463	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
111780009464	diaminopimelate epimerase; Region: PLN02536
111780009465	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
111780009466	Sm and related proteins; Region: Sm_like; cl00259
111780009467	heptamer interface [polypeptide binding]; other site
111780009468	Sm1 motif; other site
111780009469	hexamer interface [polypeptide binding]; other site
111780009470	RNA binding site [nucleotide binding]; other site
111780009471	Sm2 motif; other site
111780009472	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780009473	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
111780009474	Coenzyme A binding pocket [chemical binding]; other site
111780009475	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
111780009476	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780009477	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
111780009478	dimerization interface [polypeptide binding]; other site
111780009479	substrate binding pocket [chemical binding]; other site
111780009480	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
111780009481	putative active site [active]
111780009482	catalytic site [active]
111780009483	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
111780009484	PLD-like domain; Region: PLDc_2; pfam13091
111780009485	putative active site [active]
111780009486	catalytic site [active]
111780009487	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780009488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009489	active site
111780009490	phosphorylation site [posttranslational modification]
111780009491	intermolecular recognition site; other site
111780009492	dimerization interface [polypeptide binding]; other site
111780009493	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
111780009494	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
111780009495	ATP binding site [chemical binding]; other site
111780009496	putative Mg++ binding site [ion binding]; other site
111780009497	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
111780009498	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
111780009499	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780009500	dimerization interface [polypeptide binding]; other site
111780009501	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780009502	PAS domain; Region: PAS; smart00091
111780009503	putative active site [active]
111780009504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780009505	dimer interface [polypeptide binding]; other site
111780009506	phosphorylation site [posttranslational modification]
111780009507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780009508	ATP binding site [chemical binding]; other site
111780009509	Mg2+ binding site [ion binding]; other site
111780009510	G-X-G motif; other site
111780009511	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
111780009512	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
111780009513	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
111780009514	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
111780009515	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780009516	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009517	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780009518	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009519	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009520	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009521	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
111780009522	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
111780009523	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
111780009524	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780009525	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780009526	Walker A/P-loop; other site
111780009527	ATP binding site [chemical binding]; other site
111780009528	Q-loop/lid; other site
111780009529	ABC transporter signature motif; other site
111780009530	Walker B; other site
111780009531	D-loop; other site
111780009532	H-loop/switch region; other site
111780009533	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
111780009534	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
111780009535	putative active site [active]
111780009536	oxyanion strand; other site
111780009537	catalytic triad [active]
111780009538	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
111780009539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780009540	S-adenosylmethionine binding site [chemical binding]; other site
111780009541	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
111780009542	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
111780009543	TPP-binding site; other site
111780009544	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
111780009545	PYR/PP interface [polypeptide binding]; other site
111780009546	dimer interface [polypeptide binding]; other site
111780009547	TPP binding site [chemical binding]; other site
111780009548	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
111780009549	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
111780009550	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780009551	ATP binding site [chemical binding]; other site
111780009552	putative Mg++ binding site [ion binding]; other site
111780009553	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780009554	nucleotide binding region [chemical binding]; other site
111780009555	ATP-binding site [chemical binding]; other site
111780009556	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
111780009557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
111780009558	HRDC domain; Region: HRDC; pfam00570
111780009559	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
111780009560	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
111780009561	active site
111780009562	purine riboside binding site [chemical binding]; other site
111780009563	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
111780009564	core domain interface [polypeptide binding]; other site
111780009565	delta subunit interface [polypeptide binding]; other site
111780009566	epsilon subunit interface [polypeptide binding]; other site
111780009567	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
111780009568	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
111780009569	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
111780009570	beta subunit interaction interface [polypeptide binding]; other site
111780009571	Walker A motif; other site
111780009572	ATP binding site [chemical binding]; other site
111780009573	Walker B motif; other site
111780009574	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
111780009575	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
111780009576	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
111780009577	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
111780009578	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
111780009579	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
111780009580	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
111780009581	ATP synthase CF0 C subunit; Region: atpH; CHL00061
111780009582	ATP synthase CF0 A subunit; Region: atpI; CHL00046
111780009583	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
111780009584	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780009585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780009586	S-adenosylmethionine binding site [chemical binding]; other site
111780009587	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
111780009588	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
111780009589	Walker A/P-loop; other site
111780009590	ATP binding site [chemical binding]; other site
111780009591	Q-loop/lid; other site
111780009592	ABC transporter signature motif; other site
111780009593	Walker B; other site
111780009594	D-loop; other site
111780009595	H-loop/switch region; other site
111780009596	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
111780009597	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
111780009598	Walker A/P-loop; other site
111780009599	ATP binding site [chemical binding]; other site
111780009600	Q-loop/lid; other site
111780009601	ABC transporter signature motif; other site
111780009602	Walker B; other site
111780009603	D-loop; other site
111780009604	H-loop/switch region; other site
111780009605	NMT1-like family; Region: NMT1_2; pfam13379
111780009606	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
111780009607	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
111780009608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780009609	dimer interface [polypeptide binding]; other site
111780009610	conserved gate region; other site
111780009611	putative PBP binding loops; other site
111780009612	ABC-ATPase subunit interface; other site
111780009613	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
111780009614	NMT1-like family; Region: NMT1_2; pfam13379
111780009615	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
111780009616	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
111780009617	Response regulator receiver domain; Region: Response_reg; pfam00072
111780009618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009619	active site
111780009620	phosphorylation site [posttranslational modification]
111780009621	intermolecular recognition site; other site
111780009622	dimerization interface [polypeptide binding]; other site
111780009623	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
111780009624	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780009625	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780009626	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780009627	ligand binding site [chemical binding]; other site
111780009628	flexible hinge region; other site
111780009629	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
111780009630	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
111780009631	putative active site [active]
111780009632	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
111780009633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780009634	Walker A/P-loop; other site
111780009635	ATP binding site [chemical binding]; other site
111780009636	Q-loop/lid; other site
111780009637	ABC transporter signature motif; other site
111780009638	Walker B; other site
111780009639	D-loop; other site
111780009640	H-loop/switch region; other site
111780009641	Homeodomain-like domain; Region: HTH_23; pfam13384
111780009642	Winged helix-turn helix; Region: HTH_29; pfam13551
111780009643	HTH-like domain; Region: HTH_21; pfam13276
111780009644	Phosphotransferase enzyme family; Region: APH; pfam01636
111780009645	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
111780009646	substrate binding site [chemical binding]; other site
111780009647	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
111780009648	endonuclease III; Region: ENDO3c; smart00478
111780009649	minor groove reading motif; other site
111780009650	helix-hairpin-helix signature motif; other site
111780009651	substrate binding pocket [chemical binding]; other site
111780009652	active site
111780009653	ketol-acid reductoisomerase; Provisional; Region: PRK05479
111780009654	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
111780009655	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
111780009656	Predicted membrane protein [Function unknown]; Region: COG1950
111780009657	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
111780009658	short chain dehydrogenase; Validated; Region: PRK06182
111780009659	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
111780009660	NADP binding site [chemical binding]; other site
111780009661	active site
111780009662	steroid binding site; other site
111780009663	GMP synthase; Reviewed; Region: guaA; PRK00074
111780009664	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
111780009665	AMP/PPi binding site [chemical binding]; other site
111780009666	candidate oxyanion hole; other site
111780009667	catalytic triad [active]
111780009668	potential glutamine specificity residues [chemical binding]; other site
111780009669	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
111780009670	ATP Binding subdomain [chemical binding]; other site
111780009671	Ligand Binding sites [chemical binding]; other site
111780009672	Dimerization subdomain; other site
111780009673	Response regulator receiver domain; Region: Response_reg; pfam00072
111780009674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780009675	active site
111780009676	phosphorylation site [posttranslational modification]
111780009677	intermolecular recognition site; other site
111780009678	dimerization interface [polypeptide binding]; other site
111780009679	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
111780009680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780009681	FeS/SAM binding site; other site
111780009682	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
111780009683	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
111780009684	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
111780009685	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
111780009686	RNA binding surface [nucleotide binding]; other site
111780009687	PEP-CTERM motif; Region: VPEP; pfam07589
111780009688	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
111780009689	GxxExxY protein; Region: GxxExxY; TIGR04256
111780009690	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
111780009691	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
111780009692	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
111780009693	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
111780009694	active site
111780009695	SAM binding site [chemical binding]; other site
111780009696	homodimer interface [polypeptide binding]; other site
111780009697	CP12 domain; Region: CP12; pfam02672
111780009698	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
111780009699	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
111780009700	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
111780009701	active site
111780009702	substrate binding site [chemical binding]; other site
111780009703	metal binding site [ion binding]; metal-binding site
111780009704	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780009705	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
111780009706	ligand binding site [chemical binding]; other site
111780009707	flexible hinge region; other site
111780009708	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
111780009709	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
111780009710	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
111780009711	sulfate transport protein; Provisional; Region: cysT; CHL00187
111780009712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780009713	dimer interface [polypeptide binding]; other site
111780009714	conserved gate region; other site
111780009715	putative PBP binding loops; other site
111780009716	ABC-ATPase subunit interface; other site
111780009717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780009718	dimer interface [polypeptide binding]; other site
111780009719	conserved gate region; other site
111780009720	putative PBP binding loops; other site
111780009721	ABC-ATPase subunit interface; other site
111780009722	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
111780009723	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
111780009724	Walker A/P-loop; other site
111780009725	ATP binding site [chemical binding]; other site
111780009726	Q-loop/lid; other site
111780009727	ABC transporter signature motif; other site
111780009728	Walker B; other site
111780009729	D-loop; other site
111780009730	H-loop/switch region; other site
111780009731	TOBE-like domain; Region: TOBE_3; pfam12857
111780009732	adaptive-response sensory kinase; Validated; Region: PRK09303
111780009733	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
111780009734	tetramer interface [polypeptide binding]; other site
111780009735	dimer interface [polypeptide binding]; other site
111780009736	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780009737	dimer interface [polypeptide binding]; other site
111780009738	phosphorylation site [posttranslational modification]
111780009739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780009740	ATP binding site [chemical binding]; other site
111780009741	Mg2+ binding site [ion binding]; other site
111780009742	G-X-G motif; other site
111780009743	Uncharacterized conserved protein [Function unknown]; Region: COG1543
111780009744	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
111780009745	active site
111780009746	substrate binding site [chemical binding]; other site
111780009747	catalytic site [active]
111780009748	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
111780009749	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
111780009750	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
111780009751	dimer interface [polypeptide binding]; other site
111780009752	putative functional site; other site
111780009753	putative MPT binding site; other site
111780009754	RDD family; Region: RDD; pfam06271
111780009755	ribosomal protein L33; Region: rpl33; CHL00104
111780009756	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
111780009757	Exoribonuclease R [Transcription]; Region: VacB; COG0557
111780009758	RNB domain; Region: RNB; pfam00773
111780009759	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
111780009760	anti sigma factor interaction site; other site
111780009761	regulatory phosphorylation site [posttranslational modification]; other site
111780009762	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
111780009763	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
111780009764	B12 binding site [chemical binding]; other site
111780009765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780009766	FeS/SAM binding site; other site
111780009767	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
111780009768	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
111780009769	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
111780009770	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
111780009771	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
111780009772	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
111780009773	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
111780009774	dimer interface [polypeptide binding]; other site
111780009775	decamer (pentamer of dimers) interface [polypeptide binding]; other site
111780009776	catalytic triad [active]
111780009777	peroxidatic and resolving cysteines [active]
111780009778	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
111780009779	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780009780	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780009781	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780009782	DNA binding residues [nucleotide binding]
111780009783	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
111780009784	active site lid residues [active]
111780009785	substrate binding pocket [chemical binding]; other site
111780009786	catalytic residues [active]
111780009787	substrate-Mg2+ binding site; other site
111780009788	aspartate-rich region 1; other site
111780009789	aspartate-rich region 2; other site
111780009790	phytoene desaturase; Region: phytoene_desat; TIGR02731
111780009791	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780009792	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
111780009793	DNA polymerase III subunit beta; Validated; Region: PRK05643
111780009794	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
111780009795	putative DNA binding surface [nucleotide binding]; other site
111780009796	dimer interface [polypeptide binding]; other site
111780009797	beta-clamp/clamp loader binding surface; other site
111780009798	beta-clamp/translesion DNA polymerase binding surface; other site
111780009799	Src homology 2 (SH2) domain; Region: SH2; cl15255
111780009800	phosphotyrosine binding pocket [polypeptide binding]; other site
111780009801	hydrophobic binding pocket [polypeptide binding]; other site
111780009802	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
111780009803	putative GSH binding site [chemical binding]; other site
111780009804	catalytic residues [active]
111780009805	BolA-like protein; Region: BolA; pfam01722
111780009806	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
111780009807	PLD-like domain; Region: PLDc_2; pfam13091
111780009808	putative active site [active]
111780009809	catalytic site [active]
111780009810	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
111780009811	PLD-like domain; Region: PLDc_2; pfam13091
111780009812	putative active site [active]
111780009813	catalytic site [active]
111780009814	Phosphotransferase enzyme family; Region: APH; pfam01636
111780009815	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
111780009816	active site
111780009817	ATP binding site [chemical binding]; other site
111780009818	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
111780009819	substrate binding site [chemical binding]; other site
111780009820	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
111780009821	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
111780009822	Cupin domain; Region: Cupin_2; pfam07883
111780009823	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
111780009824	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
111780009825	active site
111780009826	dimer interface [polypeptide binding]; other site
111780009827	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780009828	active site
111780009829	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780009830	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009831	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009832	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780009833	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009834	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780009835	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780009836	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780009837	active site
111780009838	ATP binding site [chemical binding]; other site
111780009839	substrate binding site [chemical binding]; other site
111780009840	activation loop (A-loop); other site
111780009841	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
111780009842	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780009843	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
111780009844	Nucleotide binding site [chemical binding]; other site
111780009845	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
111780009846	SLBB domain; Region: SLBB; pfam10531
111780009847	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
111780009848	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
111780009849	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
111780009850	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
111780009851	inhibitor-cofactor binding pocket; inhibition site
111780009852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780009853	catalytic residue [active]
111780009854	Protein required for attachment to host cells; Region: Host_attach; pfam10116
111780009855	elongation factor G; Reviewed; Region: PRK00007
111780009856	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
111780009857	G1 box; other site
111780009858	putative GEF interaction site [polypeptide binding]; other site
111780009859	GTP/Mg2+ binding site [chemical binding]; other site
111780009860	Switch I region; other site
111780009861	G2 box; other site
111780009862	G3 box; other site
111780009863	Switch II region; other site
111780009864	G4 box; other site
111780009865	G5 box; other site
111780009866	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
111780009867	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
111780009868	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
111780009869	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
111780009870	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
111780009871	O-Antigen ligase; Region: Wzy_C; pfam04932
111780009872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
111780009873	Protein kinase domain; Region: Pkinase; pfam00069
111780009874	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780009875	active site
111780009876	ATP binding site [chemical binding]; other site
111780009877	substrate binding site [chemical binding]; other site
111780009878	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
111780009879	substrate binding site [chemical binding]; other site
111780009880	activation loop (A-loop); other site
111780009881	activation loop (A-loop); other site
111780009882	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
111780009883	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
111780009884	putative catalytic cysteine [active]
111780009885	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
111780009886	putative active site [active]
111780009887	metal binding site [ion binding]; metal-binding site
111780009888	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
111780009889	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
111780009890	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780009891	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780009892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780009893	dimer interface [polypeptide binding]; other site
111780009894	phosphorylation site [posttranslational modification]
111780009895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780009896	ATP binding site [chemical binding]; other site
111780009897	Mg2+ binding site [ion binding]; other site
111780009898	G-X-G motif; other site
111780009899	GTP-binding protein LepA; Provisional; Region: PRK05433
111780009900	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
111780009901	G1 box; other site
111780009902	putative GEF interaction site [polypeptide binding]; other site
111780009903	GTP/Mg2+ binding site [chemical binding]; other site
111780009904	Switch I region; other site
111780009905	G2 box; other site
111780009906	G3 box; other site
111780009907	Switch II region; other site
111780009908	G4 box; other site
111780009909	G5 box; other site
111780009910	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
111780009911	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
111780009912	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
111780009913	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
111780009914	GIY-YIG motif/motif A; other site
111780009915	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780009916	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780009917	active site
111780009918	ATP binding site [chemical binding]; other site
111780009919	substrate binding site [chemical binding]; other site
111780009920	activation loop (A-loop); other site
111780009921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780009922	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780009923	putative substrate translocation pore; other site
111780009924	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
111780009925	ATP cone domain; Region: ATP-cone; pfam03477
111780009926	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
111780009927	Class I ribonucleotide reductase; Region: RNR_I; cd01679
111780009928	active site
111780009929	dimer interface [polypeptide binding]; other site
111780009930	catalytic residues [active]
111780009931	effector binding site; other site
111780009932	R2 peptide binding site; other site
111780009933	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780009934	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
111780009935	dimer interface [polypeptide binding]; other site
111780009936	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
111780009937	putative radical transfer pathway; other site
111780009938	diiron center [ion binding]; other site
111780009939	tyrosyl radical; other site
111780009940	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
111780009941	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
111780009942	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780009943	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
111780009944	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
111780009945	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
111780009946	substrate binding site [chemical binding]; other site
111780009947	putative active site [active]
111780009948	redox center [active]
111780009949	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
111780009950	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
111780009951	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
111780009952	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780009953	FeS/SAM binding site; other site
111780009954	TRAM domain; Region: TRAM; cl01282
111780009955	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
111780009956	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
111780009957	ATP binding site [chemical binding]; other site
111780009958	Mg++ binding site [ion binding]; other site
111780009959	motif III; other site
111780009960	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780009961	nucleotide binding region [chemical binding]; other site
111780009962	ATP-binding site [chemical binding]; other site
111780009963	threonine synthase; Reviewed; Region: PRK06721
111780009964	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
111780009965	homodimer interface [polypeptide binding]; other site
111780009966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780009967	catalytic residue [active]
111780009968	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
111780009969	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
111780009970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780009971	Walker A motif; other site
111780009972	ATP binding site [chemical binding]; other site
111780009973	Walker B motif; other site
111780009974	Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887
111780009975	Predicted integral membrane protein [Function unknown]; Region: COG0762
111780009976	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
111780009977	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
111780009978	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
111780009979	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
111780009980	HEAT repeats; Region: HEAT_2; pfam13646
111780009981	HEAT repeats; Region: HEAT_2; pfam13646
111780009982	Phycobilisome protein; Region: Phycobilisome; cl08227
111780009983	Phycobilisome protein; Region: Phycobilisome; cl08227
111780009984	FecR protein; Region: FecR; pfam04773
111780009985	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
111780009986	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780009987	Transglycosylase; Region: Transgly; pfam00912
111780009988	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
111780009989	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
111780009990	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
111780009991	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
111780009992	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780009993	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780009994	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
111780009995	protein binding site [polypeptide binding]; other site
111780009996	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780009997	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
111780009998	active site
111780009999	metal binding site [ion binding]; metal-binding site
111780010000	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
111780010001	active site
111780010002	metal binding site [ion binding]; metal-binding site
111780010003	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
111780010004	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
111780010005	GIY-YIG motif/motif A; other site
111780010006	active site
111780010007	catalytic site [active]
111780010008	putative DNA binding site [nucleotide binding]; other site
111780010009	metal binding site [ion binding]; metal-binding site
111780010010	UvrB/uvrC motif; Region: UVR; pfam02151
111780010011	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
111780010012	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
111780010013	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
111780010014	putative active site [active]
111780010015	putative metal binding site [ion binding]; other site
111780010016	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
111780010017	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
111780010018	homodimer interface [polypeptide binding]; other site
111780010019	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
111780010020	active site pocket [active]
111780010021	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
111780010022	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
111780010023	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
111780010024	active site
111780010025	metal binding site [ion binding]; metal-binding site
111780010026	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
111780010027	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
111780010028	metal binding site 2 [ion binding]; metal-binding site
111780010029	putative DNA binding helix; other site
111780010030	metal binding site 1 [ion binding]; metal-binding site
111780010031	dimer interface [polypeptide binding]; other site
111780010032	structural Zn2+ binding site [ion binding]; other site
111780010033	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
111780010034	intracellular protease, PfpI family; Region: PfpI; TIGR01382
111780010035	proposed catalytic triad [active]
111780010036	conserved cys residue [active]
111780010037	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
111780010038	Predicted integral membrane protein [Function unknown]; Region: COG5637
111780010039	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
111780010040	putative hydrophobic ligand binding site [chemical binding]; other site
111780010041	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
111780010042	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
111780010043	NAD binding site [chemical binding]; other site
111780010044	catalytic Zn binding site [ion binding]; other site
111780010045	structural Zn binding site [ion binding]; other site
111780010046	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
111780010047	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780010048	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
111780010049	Predicted membrane protein [Function unknown]; Region: COG4244
111780010050	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
111780010051	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
111780010052	active site
111780010053	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
111780010054	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780010055	PGAP1-like protein; Region: PGAP1; pfam07819
111780010056	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
111780010057	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780010058	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780010059	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
111780010060	Cache domain; Region: Cache_2; cl07034
111780010061	HAMP domain; Region: HAMP; pfam00672
111780010062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780010063	dimer interface [polypeptide binding]; other site
111780010064	phosphorylation site [posttranslational modification]
111780010065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
111780010066	Mg2+ binding site [ion binding]; other site
111780010067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010068	ATP binding site [chemical binding]; other site
111780010069	G-X-G motif; other site
111780010070	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
111780010071	RibD C-terminal domain; Region: RibD_C; cl17279
111780010072	FOG: CBS domain [General function prediction only]; Region: COG0517
111780010073	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
111780010074	HEAT repeats; Region: HEAT_2; pfam13646
111780010075	HEAT repeats; Region: HEAT_2; pfam13646
111780010076	HEAT repeats; Region: HEAT_2; pfam13646
111780010077	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
111780010078	threonine dehydratase; Reviewed; Region: PRK09224
111780010079	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
111780010080	tetramer interface [polypeptide binding]; other site
111780010081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780010082	catalytic residue [active]
111780010083	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
111780010084	putative Ile/Val binding site [chemical binding]; other site
111780010085	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
111780010086	putative Ile/Val binding site [chemical binding]; other site
111780010087	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
111780010088	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
111780010089	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
111780010090	active site
111780010091	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
111780010092	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
111780010093	homopentamer interface [polypeptide binding]; other site
111780010094	active site
111780010095	spermidine synthase; Provisional; Region: PRK00811
111780010096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780010097	S-adenosylmethionine binding site [chemical binding]; other site
111780010098	replicative DNA helicase; Region: DnaB; TIGR00665
111780010099	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
111780010100	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
111780010101	Walker A motif; other site
111780010102	ATP binding site [chemical binding]; other site
111780010103	Walker B motif; other site
111780010104	DNA binding loops [nucleotide binding]
111780010105	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
111780010106	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780010107	active site
111780010108	DNA binding site [nucleotide binding]
111780010109	Int/Topo IB signature motif; other site
111780010110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780010111	Probable transposase; Region: OrfB_IS605; pfam01385
111780010112	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780010113	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780010114	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
111780010115	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780010116	structural tetrad; other site
111780010117	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780010118	structural tetrad; other site
111780010119	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780010120	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
111780010121	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
111780010122	active site
111780010123	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
111780010124	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
111780010125	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780010126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010127	binding surface
111780010128	TPR repeat; Region: TPR_11; pfam13414
111780010129	TPR motif; other site
111780010130	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780010131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010132	binding surface
111780010133	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780010134	TPR motif; other site
111780010135	TPR repeat; Region: TPR_11; pfam13414
111780010136	TPR repeat; Region: TPR_11; pfam13414
111780010137	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
111780010138	Protein of unknown function (DUF790); Region: DUF790; pfam05626
111780010139	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
111780010140	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
111780010141	Walker A/P-loop; other site
111780010142	ATP binding site [chemical binding]; other site
111780010143	Q-loop/lid; other site
111780010144	ABC transporter signature motif; other site
111780010145	Walker B; other site
111780010146	D-loop; other site
111780010147	H-loop/switch region; other site
111780010148	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
111780010149	Clp protease; Region: CLP_protease; pfam00574
111780010150	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
111780010151	oligomer interface [polypeptide binding]; other site
111780010152	active site residues [active]
111780010153	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
111780010154	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
111780010155	oligomer interface [polypeptide binding]; other site
111780010156	active site residues [active]
111780010157	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
111780010158	active site
111780010159	dimer interfaces [polypeptide binding]; other site
111780010160	catalytic residues [active]
111780010161	putative lipid kinase; Reviewed; Region: PRK00861
111780010162	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
111780010163	YcfA-like protein; Region: YcfA; pfam07927
111780010164	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
111780010165	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
111780010166	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
111780010167	MltA specific insert domain; Region: MltA; pfam03562
111780010168	3D domain; Region: 3D; pfam06725
111780010169	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
111780010170	metal-binding site [ion binding]
111780010171	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780010172	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780010173	putative binding surface; other site
111780010174	active site
111780010175	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780010176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010177	ATP binding site [chemical binding]; other site
111780010178	Mg2+ binding site [ion binding]; other site
111780010179	G-X-G motif; other site
111780010180	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780010181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010182	Response regulator receiver domain; Region: Response_reg; pfam00072
111780010183	active site
111780010184	phosphorylation site [posttranslational modification]
111780010185	intermolecular recognition site; other site
111780010186	dimerization interface [polypeptide binding]; other site
111780010187	Cache domain; Region: Cache_1; pfam02743
111780010188	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780010189	dimerization interface [polypeptide binding]; other site
111780010190	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780010191	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780010192	dimer interface [polypeptide binding]; other site
111780010193	putative CheW interface [polypeptide binding]; other site
111780010194	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
111780010195	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780010196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010197	active site
111780010198	phosphorylation site [posttranslational modification]
111780010199	intermolecular recognition site; other site
111780010200	dimerization interface [polypeptide binding]; other site
111780010201	Response regulator receiver domain; Region: Response_reg; pfam00072
111780010202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010203	active site
111780010204	phosphorylation site [posttranslational modification]
111780010205	intermolecular recognition site; other site
111780010206	dimerization interface [polypeptide binding]; other site
111780010207	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
111780010208	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
111780010209	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
111780010210	catalytic triad [active]
111780010211	S-layer homology domain; Region: SLH; pfam00395
111780010212	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780010213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010214	binding surface
111780010215	TPR repeat; Region: TPR_11; pfam13414
111780010216	TPR motif; other site
111780010217	TPR repeat; Region: TPR_11; pfam13414
111780010218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010219	binding surface
111780010220	TPR motif; other site
111780010221	TPR repeat; Region: TPR_11; pfam13414
111780010222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010223	TPR motif; other site
111780010224	binding surface
111780010225	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
111780010226	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
111780010227	substrate binding pocket [chemical binding]; other site
111780010228	chain length determination region; other site
111780010229	substrate-Mg2+ binding site; other site
111780010230	catalytic residues [active]
111780010231	aspartate-rich region 1; other site
111780010232	active site lid residues [active]
111780010233	aspartate-rich region 2; other site
111780010234	Divergent PAP2 family; Region: DUF212; pfam02681
111780010235	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
111780010236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780010237	S-adenosylmethionine binding site [chemical binding]; other site
111780010238	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
111780010239	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
111780010240	active site
111780010241	HIGH motif; other site
111780010242	dimer interface [polypeptide binding]; other site
111780010243	KMSKS motif; other site
111780010244	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
111780010245	active site
111780010246	dimer interface [polypeptide binding]; other site
111780010247	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
111780010248	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
111780010249	NADP binding site [chemical binding]; other site
111780010250	active site
111780010251	steroid binding site; other site
111780010252	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780010253	Coenzyme A binding pocket [chemical binding]; other site
111780010254	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780010255	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
111780010256	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
111780010257	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
111780010258	AIR carboxylase; Region: AIRC; smart01001
111780010259	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
111780010260	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
111780010261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780010262	dimer interface [polypeptide binding]; other site
111780010263	conserved gate region; other site
111780010264	ABC-ATPase subunit interface; other site
111780010265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780010266	non-specific DNA binding site [nucleotide binding]; other site
111780010267	salt bridge; other site
111780010268	sequence-specific DNA binding site [nucleotide binding]; other site
111780010269	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
111780010270	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
111780010271	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
111780010272	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
111780010273	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
111780010274	active site
111780010275	multimer interface [polypeptide binding]; other site
111780010276	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
111780010277	RNA/DNA hybrid binding site [nucleotide binding]; other site
111780010278	active site
111780010279	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780010280	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780010281	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
111780010282	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
111780010283	ligand binding site [chemical binding]; other site
111780010284	NAD binding site [chemical binding]; other site
111780010285	dimerization interface [polypeptide binding]; other site
111780010286	catalytic site [active]
111780010287	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
111780010288	putative L-serine binding site [chemical binding]; other site
111780010289	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
111780010290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780010291	S-adenosylmethionine binding site [chemical binding]; other site
111780010292	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
111780010293	active site
111780010294	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
111780010295	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780010296	Ligand Binding Site [chemical binding]; other site
111780010297	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780010298	Ligand Binding Site [chemical binding]; other site
111780010299	Family description; Region: VCBS; pfam13517
111780010300	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
111780010301	FG-GAP repeat; Region: FG-GAP; cl15299
111780010302	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
111780010303	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
111780010304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010305	TPR motif; other site
111780010306	TPR repeat; Region: TPR_11; pfam13414
111780010307	binding surface
111780010308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780010309	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780010310	Probable transposase; Region: OrfB_IS605; pfam01385
111780010311	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780010312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010313	TPR repeat; Region: TPR_11; pfam13414
111780010314	binding surface
111780010315	TPR motif; other site
111780010316	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
111780010317	Integral membrane protein TerC family; Region: TerC; cl10468
111780010318	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
111780010319	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
111780010320	HflX GTPase family; Region: HflX; cd01878
111780010321	G1 box; other site
111780010322	GTP/Mg2+ binding site [chemical binding]; other site
111780010323	Switch I region; other site
111780010324	G2 box; other site
111780010325	G3 box; other site
111780010326	Switch II region; other site
111780010327	G4 box; other site
111780010328	G5 box; other site
111780010329	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
111780010330	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
111780010331	acyl-activating enzyme (AAE) consensus motif; other site
111780010332	putative AMP binding site [chemical binding]; other site
111780010333	putative active site [active]
111780010334	putative CoA binding site [chemical binding]; other site
111780010335	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
111780010336	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
111780010337	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
111780010338	putative substrate binding site [chemical binding]; other site
111780010339	putative ATP binding site [chemical binding]; other site
111780010340	DALR anticodon binding domain; Region: DALR_1; smart00836
111780010341	anticodon binding site; other site
111780010342	tRNA binding surface [nucleotide binding]; other site
111780010343	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780010344	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
111780010345	putative switch regulator; other site
111780010346	non-specific DNA interactions [nucleotide binding]; other site
111780010347	DNA binding site [nucleotide binding]
111780010348	sequence specific DNA binding site [nucleotide binding]; other site
111780010349	putative cAMP binding site [chemical binding]; other site
111780010350	PAS domain; Region: PAS; smart00091
111780010351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780010352	PAS fold; Region: PAS_3; pfam08447
111780010353	putative active site [active]
111780010354	heme pocket [chemical binding]; other site
111780010355	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780010356	PAS domain; Region: PAS; smart00091
111780010357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780010358	dimer interface [polypeptide binding]; other site
111780010359	phosphorylation site [posttranslational modification]
111780010360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010361	ATP binding site [chemical binding]; other site
111780010362	Mg2+ binding site [ion binding]; other site
111780010363	G-X-G motif; other site
111780010364	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
111780010365	FAD binding domain; Region: FAD_binding_4; pfam01565
111780010366	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
111780010367	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780010368	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
111780010369	magnesium chelatase subunit H; Provisional; Region: PLN03241
111780010370	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
111780010371	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
111780010372	YcfA-like protein; Region: YcfA; pfam07927
111780010373	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
111780010374	PIN domain; Region: PIN_3; pfam13470
111780010375	DNA binding domain, excisionase family; Region: excise; TIGR01764
111780010376	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780010377	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780010378	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
111780010379	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
111780010380	hydroxyglutarate oxidase; Provisional; Region: PRK11728
111780010381	hypothetical protein; Validated; Region: PRK00110
111780010382	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
111780010383	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
111780010384	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780010385	putative active site [active]
111780010386	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780010387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780010388	Coenzyme A binding pocket [chemical binding]; other site
111780010389	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
111780010390	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
111780010391	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
111780010392	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
111780010393	putative NAD(P) binding site [chemical binding]; other site
111780010394	putative substrate binding site [chemical binding]; other site
111780010395	catalytic Zn binding site [ion binding]; other site
111780010396	structural Zn binding site [ion binding]; other site
111780010397	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
111780010398	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780010399	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780010400	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
111780010401	putative acyl-acceptor binding pocket; other site
111780010402	Phosphate acyltransferases; Region: PlsC; smart00563
111780010403	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
111780010404	PemK-like protein; Region: PemK; cl00995
111780010405	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
111780010406	Fatty acid desaturase; Region: FA_desaturase; pfam00487
111780010407	Di-iron ligands [ion binding]; other site
111780010408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
111780010409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
111780010410	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780010411	CAAX protease self-immunity; Region: Abi; pfam02517
111780010412	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
111780010413	hydrolase, alpha/beta fold family protein; Region: PLN02824
111780010414	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
111780010415	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
111780010416	catalytic site [active]
111780010417	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
111780010418	Ferredoxin [Energy production and conversion]; Region: COG1146
111780010419	Cache domain; Region: Cache_1; pfam02743
111780010420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780010421	HAMP domain; Region: HAMP; pfam00672
111780010422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780010423	dimer interface [polypeptide binding]; other site
111780010424	phosphorylation site [posttranslational modification]
111780010425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010426	ATP binding site [chemical binding]; other site
111780010427	Mg2+ binding site [ion binding]; other site
111780010428	G-X-G motif; other site
111780010429	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
111780010430	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
111780010431	NADP binding site [chemical binding]; other site
111780010432	active site
111780010433	putative substrate binding site [chemical binding]; other site
111780010434	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
111780010435	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
111780010436	NADP-binding site; other site
111780010437	homotetramer interface [polypeptide binding]; other site
111780010438	substrate binding site [chemical binding]; other site
111780010439	homodimer interface [polypeptide binding]; other site
111780010440	active site
111780010441	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780010442	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
111780010443	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780010444	putative ADP-binding pocket [chemical binding]; other site
111780010445	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
111780010446	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
111780010447	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780010448	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
111780010449	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
111780010450	dimer interface [polypeptide binding]; other site
111780010451	ssDNA binding site [nucleotide binding]; other site
111780010452	tetramer (dimer of dimers) interface [polypeptide binding]; other site
111780010453	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
111780010454	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
111780010455	putative catalytic cysteine [active]
111780010456	Holliday junction resolvasome, endonuclease subunit [DNA replication, recombination, and repair]; Region: RuvC; COG0817
111780010457	active site
111780010458	putative DNA-binding cleft [nucleotide binding]; other site
111780010459	dimer interface [polypeptide binding]; other site
111780010460	aspartate aminotransferase; Provisional; Region: PRK05942
111780010461	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780010462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780010463	homodimer interface [polypeptide binding]; other site
111780010464	catalytic residue [active]
111780010465	glycogen synthase; Provisional; Region: glgA; PRK00654
111780010466	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
111780010467	ADP-binding pocket [chemical binding]; other site
111780010468	homodimer interface [polypeptide binding]; other site
111780010469	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
111780010470	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
111780010471	ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857
111780010472	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
111780010473	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
111780010474	active site
111780010475	catalytic residues [active]
111780010476	metal binding site [ion binding]; metal-binding site
111780010477	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
111780010478	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
111780010479	active site residue [active]
111780010480	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
111780010481	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
111780010482	substrate binding site [chemical binding]; other site
111780010483	catalytic Zn binding site [ion binding]; other site
111780010484	NAD binding site [chemical binding]; other site
111780010485	structural Zn binding site [ion binding]; other site
111780010486	dimer interface [polypeptide binding]; other site
111780010487	cytochrome c-550; Provisional; Region: psbV; PRK13621
111780010488	cytochrome c-550; Region: PS_II_C550; TIGR03045
111780010489	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
111780010490	active site
111780010491	SAM binding site [chemical binding]; other site
111780010492	homodimer interface [polypeptide binding]; other site
111780010493	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
111780010494	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
111780010495	putative active site [active]
111780010496	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
111780010497	putative active site [active]
111780010498	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780010499	Chain length determinant protein; Region: Wzz; pfam02706
111780010500	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
111780010501	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780010502	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780010503	active site
111780010504	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
111780010505	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
111780010506	GDP-binding site [chemical binding]; other site
111780010507	ACT binding site; other site
111780010508	IMP binding site; other site
111780010509	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
111780010510	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
111780010511	5S rRNA interface [nucleotide binding]; other site
111780010512	CTC domain interface [polypeptide binding]; other site
111780010513	L16 interface [polypeptide binding]; other site
111780010514	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
111780010515	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
111780010516	iron-sulfur cluster [ion binding]; other site
111780010517	[2Fe-2S] cluster binding site [ion binding]; other site
111780010518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
111780010519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
111780010520	prolyl-tRNA synthetase; Provisional; Region: PRK09194
111780010521	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
111780010522	dimer interface [polypeptide binding]; other site
111780010523	motif 1; other site
111780010524	active site
111780010525	motif 2; other site
111780010526	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
111780010527	putative deacylase active site [active]
111780010528	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
111780010529	active site
111780010530	motif 3; other site
111780010531	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
111780010532	anticodon binding site; other site
111780010533	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
111780010534	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
111780010535	Response regulator receiver domain; Region: Response_reg; pfam00072
111780010536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010537	active site
111780010538	phosphorylation site [posttranslational modification]
111780010539	intermolecular recognition site; other site
111780010540	dimerization interface [polypeptide binding]; other site
111780010541	Response regulator receiver domain; Region: Response_reg; pfam00072
111780010542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010543	active site
111780010544	phosphorylation site [posttranslational modification]
111780010545	intermolecular recognition site; other site
111780010546	dimerization interface [polypeptide binding]; other site
111780010547	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780010548	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780010549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010550	binding surface
111780010551	TPR motif; other site
111780010552	HAMP domain; Region: HAMP; pfam00672
111780010553	dimerization interface [polypeptide binding]; other site
111780010554	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780010555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780010556	dimer interface [polypeptide binding]; other site
111780010557	putative CheW interface [polypeptide binding]; other site
111780010558	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
111780010559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780010560	dimer interface [polypeptide binding]; other site
111780010561	ABC-ATPase subunit interface; other site
111780010562	putative PBP binding loops; other site
111780010563	PA14 domain; Region: PA14; cl08459
111780010564	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
111780010565	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
111780010566	Zn binding site [ion binding]; other site
111780010567	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
111780010568	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
111780010569	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780010570	catalytic residue [active]
111780010571	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
111780010572	methionine sulfoxide reductase A; Provisional; Region: PRK00058
111780010573	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
111780010574	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
111780010575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780010576	Walker A/P-loop; other site
111780010577	ATP binding site [chemical binding]; other site
111780010578	Q-loop/lid; other site
111780010579	ABC transporter signature motif; other site
111780010580	Walker B; other site
111780010581	D-loop; other site
111780010582	H-loop/switch region; other site
111780010583	TOBE domain; Region: TOBE_2; pfam08402
111780010584	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
111780010585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780010586	motif II; other site
111780010587	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
111780010588	Active_site [active]
111780010589	PAS domain S-box; Region: sensory_box; TIGR00229
111780010590	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780010591	putative active site [active]
111780010592	heme pocket [chemical binding]; other site
111780010593	GAF domain; Region: GAF_2; pfam13185
111780010594	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
111780010595	cyclase homology domain; Region: CHD; cd07302
111780010596	nucleotidyl binding site; other site
111780010597	metal binding site [ion binding]; metal-binding site
111780010598	dimer interface [polypeptide binding]; other site
111780010599	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
111780010600	Rab subfamily motif 1 (RabSF1); other site
111780010601	G1 box; other site
111780010602	GTP/Mg2+ binding site [chemical binding]; other site
111780010603	Rab subfamily motif 2 (RabSF2); other site
111780010604	Switch I region; other site
111780010605	G2 box; other site
111780010606	effector interaction site; other site
111780010607	GDI interaction site; other site
111780010608	Rab family motif 1 (RabF1); other site
111780010609	GEF interaction site [polypeptide binding]; other site
111780010610	Rab family motif 2 (RabF2); other site
111780010611	G3 box; other site
111780010612	Switch II region; other site
111780010613	Rab family motif 3 (RabF3); other site
111780010614	Rab family motif 4 (RabF4); other site
111780010615	Rab family motif 5 (RabF5); other site
111780010616	Rab subfamily motif 3 (RabSF3); other site
111780010617	G4 box; other site
111780010618	G5 box; other site
111780010619	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
111780010620	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
111780010621	ligand binding site [chemical binding]; other site
111780010622	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
111780010623	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780010624	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780010625	putative active site [active]
111780010626	heme pocket [chemical binding]; other site
111780010627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780010628	dimer interface [polypeptide binding]; other site
111780010629	phosphorylation site [posttranslational modification]
111780010630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010631	ATP binding site [chemical binding]; other site
111780010632	G-X-G motif; other site
111780010633	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
111780010634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
111780010635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
111780010636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
111780010637	catalytic residue [active]
111780010638	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
111780010639	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
111780010640	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
111780010641	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
111780010642	minor groove reading motif; other site
111780010643	helix-hairpin-helix signature motif; other site
111780010644	substrate binding pocket [chemical binding]; other site
111780010645	active site
111780010646	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
111780010647	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
111780010648	active site
111780010649	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
111780010650	protein binding site [polypeptide binding]; other site
111780010651	RIP metalloprotease RseP; Region: TIGR00054
111780010652	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
111780010653	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
111780010654	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780010655	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780010656	Probable transposase; Region: OrfB_IS605; pfam01385
111780010657	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780010658	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
111780010659	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
111780010660	dimer interface [polypeptide binding]; other site
111780010661	ssDNA binding site [nucleotide binding]; other site
111780010662	tetramer (dimer of dimers) interface [polypeptide binding]; other site
111780010663	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
111780010664	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
111780010665	active site
111780010666	Substrate binding site; other site
111780010667	Mg++ binding site; other site
111780010668	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
111780010669	putative trimer interface [polypeptide binding]; other site
111780010670	putative CoA binding site [chemical binding]; other site
111780010671	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
111780010672	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
111780010673	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
111780010674	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
111780010675	Pantoate-beta-alanine ligase; Region: PanC; cd00560
111780010676	active site
111780010677	ATP-binding site [chemical binding]; other site
111780010678	pantoate-binding site; other site
111780010679	HXXH motif; other site
111780010680	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
111780010681	CMP-binding site; other site
111780010682	The sites determining sugar specificity; other site
111780010683	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
111780010684	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
111780010685	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
111780010686	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
111780010687	dimerization interface [polypeptide binding]; other site
111780010688	putative ATP binding site [chemical binding]; other site
111780010689	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
111780010690	HD domain; Region: HD_4; pfam13328
111780010691	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
111780010692	synthetase active site [active]
111780010693	NTP binding site [chemical binding]; other site
111780010694	metal binding site [ion binding]; metal-binding site
111780010695	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
111780010696	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
111780010697	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
111780010698	competence damage-inducible protein A; Provisional; Region: PRK00549
111780010699	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
111780010700	putative MPT binding site; other site
111780010701	Competence-damaged protein; Region: CinA; pfam02464
111780010702	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
111780010703	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
111780010704	Mg++ binding site [ion binding]; other site
111780010705	putative catalytic motif [active]
111780010706	substrate binding site [chemical binding]; other site
111780010707	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
111780010708	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
111780010709	dimer interface [polypeptide binding]; other site
111780010710	active site
111780010711	glycine-pyridoxal phosphate binding site [chemical binding]; other site
111780010712	folate binding site [chemical binding]; other site
111780010713	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
111780010714	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
111780010715	active site
111780010716	HIGH motif; other site
111780010717	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
111780010718	KMSKS motif; other site
111780010719	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
111780010720	tRNA binding surface [nucleotide binding]; other site
111780010721	anticodon binding site; other site
111780010722	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
111780010723	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780010724	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
111780010725	Cytotoxic; Region: Cytotoxic; pfam09000
111780010726	DDE superfamily endonuclease; Region: DDE_5; cl17874
111780010727	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
111780010728	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
111780010729	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
111780010730	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780010731	motif II; other site
111780010732	epoxyqueuosine reductase; Region: TIGR00276
111780010733	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
111780010734	Rubrerythrin [Energy production and conversion]; Region: COG1592
111780010735	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780010736	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
111780010737	putative ADP-binding pocket [chemical binding]; other site
111780010738	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780010739	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
111780010740	DXD motif; other site
111780010741	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
111780010742	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
111780010743	short chain dehydrogenase; Provisional; Region: PRK12367
111780010744	NAD(P) binding site [chemical binding]; other site
111780010745	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
111780010746	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
111780010747	Walker A/P-loop; other site
111780010748	ATP binding site [chemical binding]; other site
111780010749	Q-loop/lid; other site
111780010750	ABC transporter signature motif; other site
111780010751	Walker B; other site
111780010752	D-loop; other site
111780010753	H-loop/switch region; other site
111780010754	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
111780010755	CHASE3 domain; Region: CHASE3; pfam05227
111780010756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
111780010757	dimer interface [polypeptide binding]; other site
111780010758	phosphorylation site [posttranslational modification]
111780010759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010760	ATP binding site [chemical binding]; other site
111780010761	Mg2+ binding site [ion binding]; other site
111780010762	G-X-G motif; other site
111780010763	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
111780010764	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
111780010765	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
111780010766	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780010767	active site
111780010768	ATP binding site [chemical binding]; other site
111780010769	substrate binding site [chemical binding]; other site
111780010770	activation loop (A-loop); other site
111780010771	PAC2 family; Region: PAC2; cl00847
111780010772	TPR repeat; Region: TPR_11; pfam13414
111780010773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780010774	binding surface
111780010775	TPR motif; other site
111780010776	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780010777	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780010778	catalytic loop [active]
111780010779	iron binding site [ion binding]; other site
111780010780	Phycobilisome protein; Region: Phycobilisome; cl08227
111780010781	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780010782	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780010783	catalytic loop [active]
111780010784	iron binding site [ion binding]; other site
111780010785	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
111780010786	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
111780010787	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
111780010788	V4R domain; Region: V4R; pfam02830
111780010789	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
111780010790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780010791	ABC-ATPase subunit interface; other site
111780010792	putative PBP binding loops; other site
111780010793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780010794	dimer interface [polypeptide binding]; other site
111780010795	conserved gate region; other site
111780010796	putative PBP binding loops; other site
111780010797	ABC-ATPase subunit interface; other site
111780010798	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
111780010799	Protein export membrane protein; Region: SecD_SecF; pfam02355
111780010800	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
111780010801	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
111780010802	hypothetical protein; Provisional; Region: PRK02509
111780010803	Uncharacterized conserved protein [Function unknown]; Region: COG1615
111780010804	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780010805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780010806	S-adenosylmethionine binding site [chemical binding]; other site
111780010807	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
111780010808	Cytochrome P450; Region: p450; cl12078
111780010809	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780010810	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
111780010811	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
111780010812	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
111780010813	YcfA-like protein; Region: YcfA; cl00752
111780010814	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
111780010815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780010816	Walker A/P-loop; other site
111780010817	ATP binding site [chemical binding]; other site
111780010818	Q-loop/lid; other site
111780010819	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
111780010820	ABC transporter signature motif; other site
111780010821	Walker B; other site
111780010822	D-loop; other site
111780010823	ABC transporter; Region: ABC_tran_2; pfam12848
111780010824	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
111780010825	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780010826	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780010827	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780010828	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
111780010829	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
111780010830	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780010831	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
111780010832	TAP-like protein; Region: Abhydrolase_4; pfam08386
111780010833	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780010834	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
111780010835	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780010836	active site
111780010837	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
111780010838	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780010839	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
111780010840	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780010841	active site
111780010842	Acyltransferase family; Region: Acyl_transf_3; pfam01757
111780010843	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
111780010844	putative catalytic site [active]
111780010845	putative metal binding site [ion binding]; other site
111780010846	putative phosphate binding site [ion binding]; other site
111780010847	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
111780010848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
111780010849	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
111780010850	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
111780010851	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
111780010852	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
111780010853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780010854	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780010855	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
111780010856	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
111780010857	active site
111780010858	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
111780010859	active site
111780010860	catalytic triad [active]
111780010861	oxyanion hole [active]
111780010862	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
111780010863	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
111780010864	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
111780010865	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
111780010866	Sodium Bile acid symporter family; Region: SBF; cl17470
111780010867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780010868	putative substrate translocation pore; other site
111780010869	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780010870	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
111780010871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780010872	non-specific DNA binding site [nucleotide binding]; other site
111780010873	salt bridge; other site
111780010874	sequence-specific DNA binding site [nucleotide binding]; other site
111780010875	PBP superfamily domain; Region: PBP_like; pfam12727
111780010876	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
111780010877	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
111780010878	UbiA prenyltransferase family; Region: UbiA; pfam01040
111780010879	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
111780010880	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
111780010881	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780010882	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780010883	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780010884	DNA binding residues [nucleotide binding]
111780010885	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
111780010886	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
111780010887	substrate binding pocket [chemical binding]; other site
111780010888	membrane-bound complex binding site; other site
111780010889	hinge residues; other site
111780010890	Predicted flavoprotein [General function prediction only]; Region: COG0431
111780010891	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
111780010892	S-layer homology domain; Region: SLH; pfam00395
111780010893	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
111780010894	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
111780010895	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
111780010896	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
111780010897	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
111780010898	TMP-binding site; other site
111780010899	ATP-binding site [chemical binding]; other site
111780010900	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
111780010901	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780010902	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
111780010903	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
111780010904	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
111780010905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780010906	homodimer interface [polypeptide binding]; other site
111780010907	catalytic residue [active]
111780010908	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
111780010909	IHF dimer interface [polypeptide binding]; other site
111780010910	IHF - DNA interface [nucleotide binding]; other site
111780010911	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
111780010912	Secretin and TonB N terminus short domain; Region: STN; pfam07660
111780010913	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
111780010914	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
111780010915	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
111780010916	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
111780010917	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
111780010918	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
111780010919	TM2 domain; Region: TM2; pfam05154
111780010920	Peptidase family M48; Region: Peptidase_M48; pfam01435
111780010921	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
111780010922	CAAX protease self-immunity; Region: Abi; pfam02517
111780010923	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780010924	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
111780010925	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
111780010926	translation initiation factor IF-2; Region: IF-2; TIGR00487
111780010927	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
111780010928	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
111780010929	G1 box; other site
111780010930	putative GEF interaction site [polypeptide binding]; other site
111780010931	GTP/Mg2+ binding site [chemical binding]; other site
111780010932	Switch I region; other site
111780010933	G2 box; other site
111780010934	G3 box; other site
111780010935	Switch II region; other site
111780010936	G4 box; other site
111780010937	G5 box; other site
111780010938	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
111780010939	Translation-initiation factor 2; Region: IF-2; pfam11987
111780010940	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
111780010941	Protein of unknown function (DUF448); Region: DUF448; pfam04296
111780010942	putative RNA binding cleft [nucleotide binding]; other site
111780010943	transcription elongation factor NusA; Provisional; Region: nusA; PRK12329
111780010944	NusA N-terminal domain; Region: NusA_N; pfam08529
111780010945	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
111780010946	RNA binding site [nucleotide binding]; other site
111780010947	homodimer interface [polypeptide binding]; other site
111780010948	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
111780010949	G-X-X-G motif; other site
111780010950	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
111780010951	G-X-X-G motif; other site
111780010952	ribosome maturation protein RimP; Reviewed; Region: PRK00092
111780010953	Sm and related proteins; Region: Sm_like; cl00259
111780010954	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
111780010955	putative oligomer interface [polypeptide binding]; other site
111780010956	putative RNA binding site [nucleotide binding]; other site
111780010957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
111780010958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
111780010959	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
111780010960	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
111780010961	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
111780010962	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
111780010963	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
111780010964	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
111780010965	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780010966	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
111780010967	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
111780010968	RNA binding site [nucleotide binding]; other site
111780010969	active site
111780010970	PAS domain S-box; Region: sensory_box; TIGR00229
111780010971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780010972	putative active site [active]
111780010973	heme pocket [chemical binding]; other site
111780010974	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780010975	PAS fold; Region: PAS_4; pfam08448
111780010976	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780010977	putative active site [active]
111780010978	heme pocket [chemical binding]; other site
111780010979	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780010980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780010981	dimer interface [polypeptide binding]; other site
111780010982	phosphorylation site [posttranslational modification]
111780010983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780010984	ATP binding site [chemical binding]; other site
111780010985	Mg2+ binding site [ion binding]; other site
111780010986	G-X-G motif; other site
111780010987	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780010988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010989	active site
111780010990	phosphorylation site [posttranslational modification]
111780010991	intermolecular recognition site; other site
111780010992	dimerization interface [polypeptide binding]; other site
111780010993	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780010994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780010995	active site
111780010996	phosphorylation site [posttranslational modification]
111780010997	intermolecular recognition site; other site
111780010998	dimerization interface [polypeptide binding]; other site
111780010999	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780011000	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780011001	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780011002	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780011003	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780011004	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780011005	metal binding site [ion binding]; metal-binding site
111780011006	active site
111780011007	I-site; other site
111780011008	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
111780011009	Family of unknown function (DUF490); Region: DUF490; pfam04357
111780011010	Family of unknown function (DUF490); Region: DUF490; pfam04357
111780011011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780011012	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
111780011013	dimer interface [polypeptide binding]; other site
111780011014	active site
111780011015	metal binding site [ion binding]; metal-binding site
111780011016	glutathione binding site [chemical binding]; other site
111780011017	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780011018	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780011019	phosphopeptide binding site; other site
111780011020	Transglycosylase; Region: Transgly; pfam00912
111780011021	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
111780011022	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
111780011023	endoglucanase; Region: PLN02420
111780011024	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
111780011025	Cellulose binding domain; Region: CBM_3; smart01067
111780011026	Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917
111780011027	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
111780011028	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
111780011029	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
111780011030	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
111780011031	O-Antigen ligase; Region: Wzy_C; pfam04932
111780011032	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780011033	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
111780011034	active site
111780011035	Uncharacterized conserved protein [Function unknown]; Region: COG3379
111780011036	Uncharacterized conserved protein [Function unknown]; Region: COG3379
111780011037	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780011038	Chain length determinant protein; Region: Wzz; pfam02706
111780011039	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
111780011040	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780011041	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780011042	Domain of unknown function (DUF955); Region: DUF955; pfam06114
111780011043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780011044	non-specific DNA binding site [nucleotide binding]; other site
111780011045	salt bridge; other site
111780011046	sequence-specific DNA binding site [nucleotide binding]; other site
111780011047	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780011048	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780011049	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780011050	active site
111780011051	ATP binding site [chemical binding]; other site
111780011052	substrate binding site [chemical binding]; other site
111780011053	activation loop (A-loop); other site
111780011054	TPR repeat; Region: TPR_11; pfam13414
111780011055	Tetratricopeptide repeat; Region: TPR_1; pfam00515
111780011056	TPR repeat; Region: TPR_11; pfam13414
111780011057	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780011058	binding surface
111780011059	TPR motif; other site
111780011060	TPR repeat; Region: TPR_11; pfam13414
111780011061	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
111780011062	isocitrate dehydrogenase; Validated; Region: PRK07362
111780011063	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780011064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011065	active site
111780011066	phosphorylation site [posttranslational modification]
111780011067	intermolecular recognition site; other site
111780011068	dimerization interface [polypeptide binding]; other site
111780011069	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780011070	DNA binding residues [nucleotide binding]
111780011071	dimerization interface [polypeptide binding]; other site
111780011072	GUN4-like; Region: GUN4; pfam05419
111780011073	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780011074	GAF domain; Region: GAF; pfam01590
111780011075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780011076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780011077	dimer interface [polypeptide binding]; other site
111780011078	phosphorylation site [posttranslational modification]
111780011079	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
111780011080	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
111780011081	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
111780011082	SmpB-tmRNA interface; other site
111780011083	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
111780011084	Glycoprotease family; Region: Peptidase_M22; pfam00814
111780011085	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
111780011086	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
111780011087	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
111780011088	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
111780011089	NAD(P) binding site [chemical binding]; other site
111780011090	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
111780011091	Predicted dehydrogenase [General function prediction only]; Region: COG0579
111780011092	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
111780011093	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780011094	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
111780011095	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
111780011096	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
111780011097	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
111780011098	active site
111780011099	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
111780011100	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
111780011101	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
111780011102	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
111780011103	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
111780011104	Surface antigen; Region: Bac_surface_Ag; pfam01103
111780011105	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
111780011106	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
111780011107	ATP binding site [chemical binding]; other site
111780011108	active site
111780011109	substrate binding site [chemical binding]; other site
111780011110	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
111780011111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780011112	dimer interface [polypeptide binding]; other site
111780011113	conserved gate region; other site
111780011114	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
111780011115	ABC-ATPase subunit interface; other site
111780011116	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
111780011117	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
111780011118	short chain dehydrogenase; Provisional; Region: PRK07454
111780011119	classical (c) SDRs; Region: SDR_c; cd05233
111780011120	NAD(P) binding site [chemical binding]; other site
111780011121	active site
111780011122	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
111780011123	homodecamer interface [polypeptide binding]; other site
111780011124	GTP cyclohydrolase I; Provisional; Region: PLN03044
111780011125	active site
111780011126	putative catalytic site residues [active]
111780011127	zinc binding site [ion binding]; other site
111780011128	GTP-CH-I/GFRP interaction surface; other site
111780011129	HPP family; Region: HPP; pfam04982
111780011130	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
111780011131	rRNA interaction site [nucleotide binding]; other site
111780011132	S8 interaction site; other site
111780011133	putative laminin-1 binding site; other site
111780011134	elongation factor Ts; Reviewed; Region: tsf; PRK12332
111780011135	UBA/TS-N domain; Region: UBA; pfam00627
111780011136	Elongation factor TS; Region: EF_TS; pfam00889
111780011137	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
111780011138	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
111780011139	generic binding surface II; other site
111780011140	ssDNA binding site; other site
111780011141	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780011142	ATP binding site [chemical binding]; other site
111780011143	putative Mg++ binding site [ion binding]; other site
111780011144	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780011145	nucleotide binding region [chemical binding]; other site
111780011146	ATP-binding site [chemical binding]; other site
111780011147	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
111780011148	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011149	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780011150	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011151	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780011152	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011153	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
111780011154	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
111780011155	putative NAD(P) binding site [chemical binding]; other site
111780011156	active site
111780011157	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
111780011158	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
111780011159	P-loop; other site
111780011160	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
111780011161	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
111780011162	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780011163	PemK-like protein; Region: PemK; pfam02452
111780011164	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
111780011165	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
111780011166	putative acyl-acceptor binding pocket; other site
111780011167	MEKHLA domain; Region: MEKHLA; pfam08670
111780011168	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
111780011169	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
111780011170	dimer interface [polypeptide binding]; other site
111780011171	putative metal binding site [ion binding]; other site
111780011172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780011173	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780011174	putative substrate translocation pore; other site
111780011175	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780011176	HSP70 interaction site [polypeptide binding]; other site
111780011177	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
111780011178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
111780011179	septum formation inhibitor; Reviewed; Region: minC; PRK00513
111780011180	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
111780011181	septum site-determining protein MinD; Region: minD_bact; TIGR01968
111780011182	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
111780011183	Switch I; other site
111780011184	Switch II; other site
111780011185	Septum formation topological specificity factor MinE; Region: MinE; cl00538
111780011186	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
111780011187	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
111780011188	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
111780011189	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
111780011190	DNA primase; Validated; Region: dnaG; PRK05667
111780011191	CHC2 zinc finger; Region: zf-CHC2; pfam01807
111780011192	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
111780011193	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
111780011194	active site
111780011195	metal binding site [ion binding]; metal-binding site
111780011196	interdomain interaction site; other site
111780011197	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
111780011198	ATP binding site [chemical binding]; other site
111780011199	putative Mg++ binding site [ion binding]; other site
111780011200	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
111780011201	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
111780011202	nucleotide binding region [chemical binding]; other site
111780011203	ATP-binding site [chemical binding]; other site
111780011204	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
111780011205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780011206	non-specific DNA binding site [nucleotide binding]; other site
111780011207	salt bridge; other site
111780011208	sequence-specific DNA binding site [nucleotide binding]; other site
111780011209	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
111780011210	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
111780011211	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
111780011212	PemK-like protein; Region: PemK; pfam02452
111780011213	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
111780011214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
111780011215	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780011216	Coenzyme A binding pocket [chemical binding]; other site
111780011217	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
111780011218	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
111780011219	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
111780011220	dimer interface [polypeptide binding]; other site
111780011221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780011222	catalytic residue [active]
111780011223	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
111780011224	GSH binding site [chemical binding]; other site
111780011225	catalytic residues [active]
111780011226	glutathione synthetase; Provisional; Region: PRK05246
111780011227	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
111780011228	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
111780011229	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
111780011230	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
111780011231	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
111780011232	catalytic triad [active]
111780011233	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
111780011234	oligomerization interface [polypeptide binding]; other site
111780011235	active site
111780011236	metal binding site [ion binding]; metal-binding site
111780011237	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
111780011238	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
111780011239	active site
111780011240	catalytic site [active]
111780011241	substrate binding site [chemical binding]; other site
111780011242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780011243	AAA domain; Region: AAA_22; pfam13401
111780011244	Walker A motif; other site
111780011245	ATP binding site [chemical binding]; other site
111780011246	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
111780011247	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
111780011248	arginine-tRNA ligase; Region: PLN02286
111780011249	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
111780011250	active site
111780011251	HIGH motif; other site
111780011252	KMSK motif region; other site
111780011253	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
111780011254	tRNA binding surface [nucleotide binding]; other site
111780011255	anticodon binding site; other site
111780011256	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
111780011257	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
111780011258	putative dimer interface [polypeptide binding]; other site
111780011259	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
111780011260	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780011261	ligand binding site [chemical binding]; other site
111780011262	flexible hinge region; other site
111780011263	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
111780011264	non-specific DNA interactions [nucleotide binding]; other site
111780011265	DNA binding site [nucleotide binding]
111780011266	sequence specific DNA binding site [nucleotide binding]; other site
111780011267	putative cAMP binding site [chemical binding]; other site
111780011268	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
111780011269	Nitrogen regulatory protein P-II; Region: P-II; smart00938
111780011270	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780011271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780011272	dimerization interface [polypeptide binding]; other site
111780011273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780011274	dimer interface [polypeptide binding]; other site
111780011275	phosphorylation site [posttranslational modification]
111780011276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780011277	ATP binding site [chemical binding]; other site
111780011278	Mg2+ binding site [ion binding]; other site
111780011279	G-X-G motif; other site
111780011280	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
111780011281	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
111780011282	active site
111780011283	(T/H)XGH motif; other site
111780011284	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
111780011285	DHH family; Region: DHH; pfam01368
111780011286	DHHA1 domain; Region: DHHA1; pfam02272
111780011287	Transcriptional regulator [Transcription]; Region: LytR; COG1316
111780011288	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
111780011289	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
111780011290	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
111780011291	GTP binding site; other site
111780011292	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
111780011293	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
111780011294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011295	active site
111780011296	phosphorylation site [posttranslational modification]
111780011297	intermolecular recognition site; other site
111780011298	dimerization interface [polypeptide binding]; other site
111780011299	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
111780011300	Zn2+ binding site [ion binding]; other site
111780011301	Mg2+ binding site [ion binding]; other site
111780011302	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
111780011303	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
111780011304	Substrate binding site; other site
111780011305	Mg++ binding site; other site
111780011306	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
111780011307	active site
111780011308	substrate binding site [chemical binding]; other site
111780011309	CoA binding site [chemical binding]; other site
111780011310	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
111780011311	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
111780011312	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
111780011313	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
111780011314	ligand binding site [chemical binding]; other site
111780011315	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
111780011316	dimer interface [polypeptide binding]; other site
111780011317	active site
111780011318	Schiff base residues; other site
111780011319	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
111780011320	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
111780011321	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
111780011322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
111780011323	dimer interface [polypeptide binding]; other site
111780011324	conserved gate region; other site
111780011325	putative PBP binding loops; other site
111780011326	ABC-ATPase subunit interface; other site
111780011327	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780011328	Probable transposase; Region: OrfB_IS605; pfam01385
111780011329	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780011330	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780011331	Tic22-like family; Region: Tic22; pfam04278
111780011332	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
111780011333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780011334	S-adenosylmethionine binding site [chemical binding]; other site
111780011335	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
111780011336	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
111780011337	Cytochrome P450; Region: p450; cl12078
111780011338	RNA polymerase sigma factor; Provisional; Region: PRK12518
111780011339	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780011340	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780011341	DNA binding residues [nucleotide binding]
111780011342	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
111780011343	dimer interface [polypeptide binding]; other site
111780011344	Protein of unknown function (DUF98); Region: DUF98; pfam01947
111780011345	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
111780011346	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
111780011347	putative active site pocket [active]
111780011348	4-fold oligomerization interface [polypeptide binding]; other site
111780011349	metal binding residues [ion binding]; metal-binding site
111780011350	3-fold/trimer interface [polypeptide binding]; other site
111780011351	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
111780011352	Peptidase family M23; Region: Peptidase_M23; pfam01551
111780011353	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780011354	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
111780011355	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
111780011356	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780011357	active site
111780011358	DNA binding site [nucleotide binding]
111780011359	Int/Topo IB signature motif; other site
111780011360	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
111780011361	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780011362	active site
111780011363	DNA binding site [nucleotide binding]
111780011364	Int/Topo IB signature motif; other site
111780011365	replicative DNA helicase; Region: DnaB; TIGR00665
111780011366	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
111780011367	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
111780011368	Walker A motif; other site
111780011369	ATP binding site [chemical binding]; other site
111780011370	Walker B motif; other site
111780011371	DNA binding loops [nucleotide binding]
111780011372	HEAT repeats; Region: HEAT_2; pfam13646
111780011373	HEAT repeats; Region: HEAT_2; pfam13646
111780011374	HEAT repeats; Region: HEAT_2; pfam13646
111780011375	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
111780011376	protein binding surface [polypeptide binding]; other site
111780011377	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
111780011378	D-xylulose kinase; Region: XylB; TIGR01312
111780011379	nucleotide binding site [chemical binding]; other site
111780011380	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
111780011381	putative active site pocket [active]
111780011382	dimerization interface [polypeptide binding]; other site
111780011383	putative catalytic residue [active]
111780011384	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
111780011385	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
111780011386	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
111780011387	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
111780011388	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780011389	FeS/SAM binding site; other site
111780011390	TRAM domain; Region: TRAM; pfam01938
111780011391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
111780011392	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
111780011393	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780011394	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
111780011395	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
111780011396	Predicted membrane protein [Function unknown]; Region: COG3431
111780011397	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
111780011398	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780011399	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
111780011400	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
111780011401	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780011402	active site
111780011403	catalytic tetrad [active]
111780011404	phosphodiesterase; Provisional; Region: PRK12704
111780011405	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
111780011406	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
111780011407	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
111780011408	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
111780011409	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
111780011410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780011411	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780011412	putative substrate translocation pore; other site
111780011413	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780011414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780011415	putative active site [active]
111780011416	heme pocket [chemical binding]; other site
111780011417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780011418	dimer interface [polypeptide binding]; other site
111780011419	phosphorylation site [posttranslational modification]
111780011420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780011421	ATP binding site [chemical binding]; other site
111780011422	Mg2+ binding site [ion binding]; other site
111780011423	G-X-G motif; other site
111780011424	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780011425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011426	active site
111780011427	phosphorylation site [posttranslational modification]
111780011428	intermolecular recognition site; other site
111780011429	dimerization interface [polypeptide binding]; other site
111780011430	SnoaL-like domain; Region: SnoaL_2; pfam12680
111780011431	PsbP; Region: PsbP; pfam01789
111780011432	Maf-like protein; Region: Maf; pfam02545
111780011433	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
111780011434	active site
111780011435	dimer interface [polypeptide binding]; other site
111780011436	Uncharacterized conserved protein [Function unknown]; Region: COG4279
111780011437	SWIM zinc finger; Region: SWIM; pfam04434
111780011438	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
111780011439	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
111780011440	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
111780011441	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
111780011442	EVE domain; Region: EVE; cl00728
111780011443	hydroxyglutarate oxidase; Provisional; Region: PRK11728
111780011444	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
111780011445	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
111780011446	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
111780011447	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
111780011448	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
111780011449	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
111780011450	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
111780011451	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
111780011452	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
111780011453	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780011454	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011455	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011456	Transcriptional regulator [Transcription]; Region: LytR; COG1316
111780011457	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
111780011458	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
111780011459	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
111780011460	Substrate binding site; other site
111780011461	Cupin domain; Region: Cupin_2; cl17218
111780011462	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
111780011463	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
111780011464	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
111780011465	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
111780011466	PsaD; Region: PsaD; pfam02531
111780011467	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
111780011468	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780011469	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780011470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780011471	dimer interface [polypeptide binding]; other site
111780011472	phosphorylation site [posttranslational modification]
111780011473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780011474	ATP binding site [chemical binding]; other site
111780011475	Mg2+ binding site [ion binding]; other site
111780011476	G-X-G motif; other site
111780011477	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
111780011478	Peptidase family M23; Region: Peptidase_M23; pfam01551
111780011479	Late competence development protein ComFB; Region: ComFB; pfam10719
111780011480	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
111780011481	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780011482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780011483	DNA binding residues [nucleotide binding]
111780011484	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
111780011485	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
111780011486	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
111780011487	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
111780011488	GTPase CgtA; Reviewed; Region: obgE; PRK12299
111780011489	GTP1/OBG; Region: GTP1_OBG; pfam01018
111780011490	Obg GTPase; Region: Obg; cd01898
111780011491	G1 box; other site
111780011492	GTP/Mg2+ binding site [chemical binding]; other site
111780011493	Switch I region; other site
111780011494	G2 box; other site
111780011495	G3 box; other site
111780011496	Switch II region; other site
111780011497	G4 box; other site
111780011498	G5 box; other site
111780011499	tellurium resistance terB-like protein; Region: terB_like; cd07177
111780011500	metal binding site [ion binding]; metal-binding site
111780011501	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
111780011502	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
111780011503	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780011504	active site
111780011505	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
111780011506	Domain of unknown function (DUF309); Region: DUF309; pfam03745
111780011507	OstA-like protein; Region: OstA; pfam03968
111780011508	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
111780011509	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
111780011510	Walker A/P-loop; other site
111780011511	ATP binding site [chemical binding]; other site
111780011512	Q-loop/lid; other site
111780011513	ABC transporter signature motif; other site
111780011514	Walker B; other site
111780011515	D-loop; other site
111780011516	H-loop/switch region; other site
111780011517	Predicted permeases [General function prediction only]; Region: COG0795
111780011518	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
111780011519	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
111780011520	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
111780011521	active site
111780011522	ribulose/triose binding site [chemical binding]; other site
111780011523	phosphate binding site [ion binding]; other site
111780011524	substrate (anthranilate) binding pocket [chemical binding]; other site
111780011525	product (indole) binding pocket [chemical binding]; other site
111780011526	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
111780011527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780011528	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
111780011529	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
111780011530	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
111780011531	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
111780011532	active site
111780011533	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
111780011534	active site
111780011535	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780011536	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
111780011537	HSP70 interaction site [polypeptide binding]; other site
111780011538	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
111780011539	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780011540	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
111780011541	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
111780011542	active site
111780011543	dimer interface [polypeptide binding]; other site
111780011544	catalytic nucleophile [active]
111780011545	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
111780011546	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
111780011547	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
111780011548	Domain of unknown function (DUF697); Region: DUF697; pfam05128
111780011549	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
111780011550	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
111780011551	Response regulator receiver domain; Region: Response_reg; pfam00072
111780011552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011553	active site
111780011554	phosphorylation site [posttranslational modification]
111780011555	intermolecular recognition site; other site
111780011556	dimerization interface [polypeptide binding]; other site
111780011557	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
111780011558	dimer interface [polypeptide binding]; other site
111780011559	[2Fe-2S] cluster binding site [ion binding]; other site
111780011560	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
111780011561	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
111780011562	dimerization interface [polypeptide binding]; other site
111780011563	DPS ferroxidase diiron center [ion binding]; other site
111780011564	ion pore; other site
111780011565	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
111780011566	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
111780011567	Active site cavity [active]
111780011568	catalytic acid [active]
111780011569	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
111780011570	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
111780011571	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
111780011572	Peptidase family M23; Region: Peptidase_M23; pfam01551
111780011573	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
111780011574	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
111780011575	agmatinase; Region: agmatinase; TIGR01230
111780011576	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
111780011577	putative active site [active]
111780011578	Mn binding site [ion binding]; other site
111780011579	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
111780011580	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780011581	putative catalytic residue [active]
111780011582	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
111780011583	putative nucleotide binding site [chemical binding]; other site
111780011584	uridine monophosphate binding site [chemical binding]; other site
111780011585	homohexameric interface [polypeptide binding]; other site
111780011586	ribosome recycling factor; Reviewed; Region: frr; PRK00083
111780011587	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
111780011588	hinge region; other site
111780011589	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
111780011590	tetramer (dimer of dimers) interface [polypeptide binding]; other site
111780011591	active site
111780011592	dimer interface [polypeptide binding]; other site
111780011593	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
111780011594	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
111780011595	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
111780011596	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780011597	Ligand Binding Site [chemical binding]; other site
111780011598	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780011599	Ligand Binding Site [chemical binding]; other site
111780011600	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
111780011601	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
111780011602	MPT binding site; other site
111780011603	trimer interface [polypeptide binding]; other site
111780011604	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
111780011605	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
111780011606	Malic enzyme, N-terminal domain; Region: malic; pfam00390
111780011607	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
111780011608	putative NAD(P) binding site [chemical binding]; other site
111780011609	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
111780011610	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
111780011611	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
111780011612	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
111780011613	lipoyl attachment site [posttranslational modification]; other site
111780011614	glycine dehydrogenase; Provisional; Region: PRK05367
111780011615	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
111780011616	tetramer interface [polypeptide binding]; other site
111780011617	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780011618	catalytic residue [active]
111780011619	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
111780011620	tetramer interface [polypeptide binding]; other site
111780011621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780011622	catalytic residue [active]
111780011623	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
111780011624	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
111780011625	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780011626	Domain of unknown function DUF20; Region: UPF0118; pfam01594
111780011627	CTP synthetase; Validated; Region: pyrG; PRK05380
111780011628	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
111780011629	Catalytic site [active]
111780011630	active site
111780011631	UTP binding site [chemical binding]; other site
111780011632	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
111780011633	active site
111780011634	putative oxyanion hole; other site
111780011635	catalytic triad [active]
111780011636	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
111780011637	intersubunit interface [polypeptide binding]; other site
111780011638	active site
111780011639	Zn2+ binding site [ion binding]; other site
111780011640	Protein of unknown function, DUF393; Region: DUF393; pfam04134
111780011641	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
111780011642	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
111780011643	C factor cell-cell signaling protein; Provisional; Region: PRK09009
111780011644	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
111780011645	NADP binding site [chemical binding]; other site
111780011646	homodimer interface [polypeptide binding]; other site
111780011647	active site
111780011648	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
111780011649	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
111780011650	Walker A/P-loop; other site
111780011651	ATP binding site [chemical binding]; other site
111780011652	Q-loop/lid; other site
111780011653	ABC transporter signature motif; other site
111780011654	Walker B; other site
111780011655	D-loop; other site
111780011656	H-loop/switch region; other site
111780011657	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
111780011658	cobalt transport protein CbiM; Validated; Region: PRK06265
111780011659	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
111780011660	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
111780011661	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
111780011662	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
111780011663	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
111780011664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
111780011665	DNA binding residues [nucleotide binding]
111780011666	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
111780011667	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
111780011668	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
111780011669	cobyric acid synthase; Provisional; Region: PRK00784
111780011670	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
111780011671	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
111780011672	catalytic triad [active]
111780011673	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
111780011674	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
111780011675	catalytic loop [active]
111780011676	iron binding site [ion binding]; other site
111780011677	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
111780011678	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
111780011679	nucleotide binding site [chemical binding]; other site
111780011680	putative NEF/HSP70 interaction site [polypeptide binding]; other site
111780011681	SBD interface [polypeptide binding]; other site
111780011682	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
111780011683	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
111780011684	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
111780011685	UreF; Region: UreF; pfam01730
111780011686	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
111780011687	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
111780011688	dimer interface [polypeptide binding]; other site
111780011689	catalytic residues [active]
111780011690	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
111780011691	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
111780011692	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780011693	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
111780011694	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
111780011695	putative dimer interface [polypeptide binding]; other site
111780011696	Uncharacterized conserved protein [Function unknown]; Region: COG2006
111780011697	Domain of unknown function (DUF362); Region: DUF362; pfam04015
111780011698	S-adenosylmethionine synthetase; Validated; Region: PRK05250
111780011699	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
111780011700	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
111780011701	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
111780011702	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
111780011703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780011704	motif II; other site
111780011705	30S ribosomal protein S1; Reviewed; Region: PRK07400
111780011706	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
111780011707	RNA binding site [nucleotide binding]; other site
111780011708	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
111780011709	RNA binding site [nucleotide binding]; other site
111780011710	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
111780011711	RNA binding site [nucleotide binding]; other site
111780011712	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
111780011713	ATP cone domain; Region: ATP-cone; pfam03477
111780011714	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
111780011715	photosystem II 47 kDa protein; Region: psbB; CHL00062
111780011716	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780011717	metal binding site [ion binding]; metal-binding site
111780011718	active site
111780011719	I-site; other site
111780011720	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780011721	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
111780011722	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
111780011723	active site
111780011724	catalytic tetrad [active]
111780011725	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780011726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011727	active site
111780011728	phosphorylation site [posttranslational modification]
111780011729	intermolecular recognition site; other site
111780011730	dimerization interface [polypeptide binding]; other site
111780011731	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780011732	DNA binding residues [nucleotide binding]
111780011733	dimerization interface [polypeptide binding]; other site
111780011734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780011735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780011736	dimer interface [polypeptide binding]; other site
111780011737	phosphorylation site [posttranslational modification]
111780011738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780011739	ATP binding site [chemical binding]; other site
111780011740	Mg2+ binding site [ion binding]; other site
111780011741	G-X-G motif; other site
111780011742	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
111780011743	PemK-like protein; Region: PemK; pfam02452
111780011744	Protein of unknown function (DUF433); Region: DUF433; pfam04255
111780011745	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
111780011746	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
111780011747	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
111780011748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780011749	Coenzyme A binding pocket [chemical binding]; other site
111780011750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
111780011751	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
111780011752	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780011753	Soluble P-type ATPase [General function prediction only]; Region: COG4087
111780011754	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
111780011755	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
111780011756	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
111780011757	Coenzyme A binding pocket [chemical binding]; other site
111780011758	PemK-like protein; Region: PemK; pfam02452
111780011759	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
111780011760	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780011761	sequence-specific DNA binding site [nucleotide binding]; other site
111780011762	salt bridge; other site
111780011763	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
111780011764	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
111780011765	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
111780011766	Ligand Binding Site [chemical binding]; other site
111780011767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780011768	TPR motif; other site
111780011769	TPR repeat; Region: TPR_11; pfam13414
111780011770	binding surface
111780011771	TPR repeat; Region: TPR_11; pfam13414
111780011772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780011773	binding surface
111780011774	TPR motif; other site
111780011775	TPR repeat; Region: TPR_11; pfam13414
111780011776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780011777	binding surface
111780011778	TPR motif; other site
111780011779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780011780	TPR motif; other site
111780011781	TPR repeat; Region: TPR_11; pfam13414
111780011782	binding surface
111780011783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
111780011784	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
111780011785	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
111780011786	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
111780011787	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780011788	putative active site [active]
111780011789	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780011790	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
111780011791	Caspase domain; Region: Peptidase_C14; pfam00656
111780011792	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780011793	structural tetrad; other site
111780011794	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780011795	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780011796	structural tetrad; other site
111780011797	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
111780011798	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
111780011799	putative active site [active]
111780011800	Uncharacterized conserved protein [Function unknown]; Region: COG2361
111780011801	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780011802	active site
111780011803	NTP binding site [chemical binding]; other site
111780011804	metal binding triad [ion binding]; metal-binding site
111780011805	antibiotic binding site [chemical binding]; other site
111780011806	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
111780011807	HD domain; Region: HD_4; pfam13328
111780011808	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
111780011809	putative active site pocket [active]
111780011810	dimerization interface [polypeptide binding]; other site
111780011811	putative catalytic residue [active]
111780011812	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
111780011813	active site
111780011814	YciI-like protein; Reviewed; Region: PRK12864
111780011815	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
111780011816	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
111780011817	FMN binding site [chemical binding]; other site
111780011818	active site
111780011819	substrate binding site [chemical binding]; other site
111780011820	catalytic residue [active]
111780011821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
111780011822	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
111780011823	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
111780011824	putative tRNA-binding site [nucleotide binding]; other site
111780011825	B3/4 domain; Region: B3_4; pfam03483
111780011826	tRNA synthetase B5 domain; Region: B5; smart00874
111780011827	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
111780011828	dimer interface [polypeptide binding]; other site
111780011829	motif 1; other site
111780011830	motif 3; other site
111780011831	motif 2; other site
111780011832	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
111780011833	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780011834	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780011835	active site
111780011836	ATP binding site [chemical binding]; other site
111780011837	substrate binding site [chemical binding]; other site
111780011838	activation loop (A-loop); other site
111780011839	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011840	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780011841	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011842	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780011843	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
111780011844	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
111780011845	gamma-beta subunit interface [polypeptide binding]; other site
111780011846	alpha-beta subunit interface [polypeptide binding]; other site
111780011847	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
111780011848	alpha-gamma subunit interface [polypeptide binding]; other site
111780011849	beta-gamma subunit interface [polypeptide binding]; other site
111780011850	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780011851	Domain of unknown function DUF20; Region: UPF0118; pfam01594
111780011852	NAD synthetase; Provisional; Region: PRK13981
111780011853	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
111780011854	multimer interface [polypeptide binding]; other site
111780011855	active site
111780011856	catalytic triad [active]
111780011857	protein interface 1 [polypeptide binding]; other site
111780011858	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
111780011859	homodimer interface [polypeptide binding]; other site
111780011860	NAD binding pocket [chemical binding]; other site
111780011861	ATP binding pocket [chemical binding]; other site
111780011862	Mg binding site [ion binding]; other site
111780011863	active-site loop [active]
111780011864	isochorismate-pyruvate lyase; Reviewed; Region: PRK07075
111780011865	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
111780011866	nudix motif; other site
111780011867	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
111780011868	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
111780011869	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
111780011870	active site
111780011871	(T/H)XGH motif; other site
111780011872	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
111780011873	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
111780011874	active site
111780011875	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780011876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780011877	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780011878	Probable transposase; Region: OrfB_IS605; pfam01385
111780011879	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
111780011880	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
111780011881	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780011882	active site
111780011883	DNA binding site [nucleotide binding]
111780011884	Int/Topo IB signature motif; other site
111780011885	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
111780011886	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780011887	active site
111780011888	DNA binding site [nucleotide binding]
111780011889	Int/Topo IB signature motif; other site
111780011890	replicative DNA helicase; Region: DnaB; TIGR00665
111780011891	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
111780011892	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
111780011893	Walker A motif; other site
111780011894	ATP binding site [chemical binding]; other site
111780011895	Walker B motif; other site
111780011896	DNA binding loops [nucleotide binding]
111780011897	exonuclease SbcC; Region: sbcc; TIGR00618
111780011898	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780011899	Walker A/P-loop; other site
111780011900	ATP binding site [chemical binding]; other site
111780011901	Q-loop/lid; other site
111780011902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
111780011903	ABC transporter signature motif; other site
111780011904	Walker B; other site
111780011905	D-loop; other site
111780011906	H-loop/switch region; other site
111780011907	ATP-grasp domain; Region: ATP-grasp_4; cl17255
111780011908	CheW-like domain; Region: CheW; pfam01584
111780011909	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780011910	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780011911	putative binding surface; other site
111780011912	active site
111780011913	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
111780011914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780011915	ATP binding site [chemical binding]; other site
111780011916	Mg2+ binding site [ion binding]; other site
111780011917	G-X-G motif; other site
111780011918	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780011919	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780011920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011921	active site
111780011922	phosphorylation site [posttranslational modification]
111780011923	intermolecular recognition site; other site
111780011924	dimerization interface [polypeptide binding]; other site
111780011925	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780011926	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780011927	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780011928	GAF domain; Region: GAF; pfam01590
111780011929	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780011930	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780011931	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
111780011932	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780011933	dimer interface [polypeptide binding]; other site
111780011934	putative CheW interface [polypeptide binding]; other site
111780011935	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780011936	Response regulator receiver domain; Region: Response_reg; pfam00072
111780011937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011938	active site
111780011939	phosphorylation site [posttranslational modification]
111780011940	intermolecular recognition site; other site
111780011941	dimerization interface [polypeptide binding]; other site
111780011942	Response regulator receiver domain; Region: Response_reg; pfam00072
111780011943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780011944	active site
111780011945	phosphorylation site [posttranslational modification]
111780011946	intermolecular recognition site; other site
111780011947	dimerization interface [polypeptide binding]; other site
111780011948	peptide chain release factor 1; Validated; Region: prfA; PRK00591
111780011949	This domain is found in peptide chain release factors; Region: PCRF; smart00937
111780011950	RF-1 domain; Region: RF-1; pfam00472
111780011951	ribosomal protein L31; Validated; Region: rpl31; CHL00136
111780011952	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
111780011953	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
111780011954	23S rRNA interface [nucleotide binding]; other site
111780011955	L3 interface [polypeptide binding]; other site
111780011956	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
111780011957	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
111780011958	dimerization interface 3.5A [polypeptide binding]; other site
111780011959	active site
111780011960	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
111780011961	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
111780011962	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
111780011963	alphaNTD homodimer interface [polypeptide binding]; other site
111780011964	alphaNTD - beta interaction site [polypeptide binding]; other site
111780011965	alphaNTD - beta' interaction site [polypeptide binding]; other site
111780011966	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
111780011967	30S ribosomal protein S11; Validated; Region: PRK05309
111780011968	ribosomal protein S13; Validated; Region: rps13; CHL00137
111780011969	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
111780011970	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
111780011971	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
111780011972	rRNA binding site [nucleotide binding]; other site
111780011973	predicted 30S ribosome binding site; other site
111780011974	adenylate kinase; Provisional; Region: adk; PRK02496
111780011975	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
111780011976	AMP-binding site [chemical binding]; other site
111780011977	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
111780011978	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
111780011979	SecY translocase; Region: SecY; pfam00344
111780011980	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
111780011981	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
111780011982	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
111780011983	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
111780011984	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
111780011985	23S rRNA interface [nucleotide binding]; other site
111780011986	L21e interface [polypeptide binding]; other site
111780011987	5S rRNA interface [nucleotide binding]; other site
111780011988	L27 interface [polypeptide binding]; other site
111780011989	L5 interface [polypeptide binding]; other site
111780011990	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
111780011991	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
111780011992	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
111780011993	ribosomal protein S8; Region: rps8; CHL00042
111780011994	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
111780011995	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
111780011996	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
111780011997	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
111780011998	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
111780011999	RNA binding site [nucleotide binding]; other site
111780012000	ribosomal protein L14; Region: rpl14; CHL00057
111780012001	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
111780012002	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
111780012003	L23 interface [polypeptide binding]; other site
111780012004	signal recognition particle (SRP54) interaction site; other site
111780012005	trigger factor interaction site; other site
111780012006	23S rRNA interface [nucleotide binding]; other site
111780012007	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
111780012008	23S rRNA interface [nucleotide binding]; other site
111780012009	5S rRNA interface [nucleotide binding]; other site
111780012010	putative antibiotic binding site [chemical binding]; other site
111780012011	L25 interface [polypeptide binding]; other site
111780012012	L27 interface [polypeptide binding]; other site
111780012013	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
111780012014	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
111780012015	G-X-X-G motif; other site
111780012016	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
111780012017	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
111780012018	putative translocon binding site; other site
111780012019	protein-rRNA interface [nucleotide binding]; other site
111780012020	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
111780012021	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
111780012022	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
111780012023	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
111780012024	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
111780012025	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
111780012026	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
111780012027	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
111780012028	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
111780012029	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
111780012030	putative valine binding site [chemical binding]; other site
111780012031	dimer interface [polypeptide binding]; other site
111780012032	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
111780012033	hydrolase, alpha/beta fold family protein; Region: PLN02824
111780012034	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
111780012035	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
111780012036	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
111780012037	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780012038	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
111780012039	active site
111780012040	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
111780012041	Calx-beta domain; Region: Calx-beta; pfam03160
111780012042	Calx-beta domain; Region: Calx-beta; cl02522
111780012043	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
111780012044	Cna protein B-type domain; Region: Cna_B; pfam05738
111780012045	TPR repeat; Region: TPR_11; pfam13414
111780012046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012047	binding surface
111780012048	TPR motif; other site
111780012049	TPR repeat; Region: TPR_11; pfam13414
111780012050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012051	binding surface
111780012052	TPR repeat; Region: TPR_11; pfam13414
111780012053	TPR motif; other site
111780012054	TPR repeat; Region: TPR_11; pfam13414
111780012055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012056	binding surface
111780012057	TPR motif; other site
111780012058	TPR repeat; Region: TPR_11; pfam13414
111780012059	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
111780012060	active site
111780012061	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
111780012062	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
111780012063	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
111780012064	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
111780012065	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
111780012066	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780012067	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
111780012068	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780012069	motif II; other site
111780012070	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
111780012071	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
111780012072	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
111780012073	Ligand binding site; other site
111780012074	Putative Catalytic site; other site
111780012075	DXD motif; other site
111780012076	Predicted membrane protein [Function unknown]; Region: COG2246
111780012077	GtrA-like protein; Region: GtrA; pfam04138
111780012078	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
111780012079	acyl-CoA synthetase; Validated; Region: PRK05850
111780012080	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
111780012081	acyl-activating enzyme (AAE) consensus motif; other site
111780012082	active site
111780012083	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
111780012084	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
111780012085	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
111780012086	active site
111780012087	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
111780012088	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
111780012089	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
111780012090	KR domain; Region: KR; pfam08659
111780012091	putative NADP binding site [chemical binding]; other site
111780012092	active site
111780012093	Phosphopantetheine attachment site; Region: PP-binding; cl09936
111780012094	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
111780012095	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780012096	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780012097	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
111780012098	lipoprotein signal peptidase; Provisional; Region: PRK14787
111780012099	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
111780012100	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
111780012101	G1 box; other site
111780012102	putative GEF interaction site [polypeptide binding]; other site
111780012103	GTP/Mg2+ binding site [chemical binding]; other site
111780012104	Switch I region; other site
111780012105	G2 box; other site
111780012106	G3 box; other site
111780012107	Switch II region; other site
111780012108	G4 box; other site
111780012109	G5 box; other site
111780012110	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
111780012111	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
111780012112	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
111780012113	NifU-like domain; Region: NifU; pfam01106
111780012114	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
111780012115	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
111780012116	GatB domain; Region: GatB_Yqey; smart00845
111780012117	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
111780012118	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
111780012119	ligand binding site; other site
111780012120	oligomer interface; other site
111780012121	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
111780012122	dimer interface [polypeptide binding]; other site
111780012123	N-terminal domain interface [polypeptide binding]; other site
111780012124	sulfate 1 binding site; other site
111780012125	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
111780012126	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
111780012127	metal binding site 2 [ion binding]; metal-binding site
111780012128	putative DNA binding helix; other site
111780012129	metal binding site 1 [ion binding]; metal-binding site
111780012130	dimer interface [polypeptide binding]; other site
111780012131	structural Zn2+ binding site [ion binding]; other site
111780012132	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012133	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780012134	Predicted membrane protein [Function unknown]; Region: COG3463
111780012135	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
111780012136	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
111780012137	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
111780012138	catalytic residues [active]
111780012139	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
111780012140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
111780012141	conserved hypothetical protein; Region: TIGR03492
111780012142	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780012143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780012144	S-adenosylmethionine binding site [chemical binding]; other site
111780012145	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
111780012146	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
111780012147	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
111780012148	active site
111780012149	catalytic residues [active]
111780012150	metal binding site [ion binding]; metal-binding site
111780012151	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
111780012152	metal ion-dependent adhesion site (MIDAS); other site
111780012153	Uncharacterized conserved protein [Function unknown]; Region: COG1359
111780012154	Predicted permeases [General function prediction only]; Region: COG0679
111780012155	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
111780012156	short chain dehydrogenase; Provisional; Region: PRK06181
111780012157	putative NAD(P) binding site [chemical binding]; other site
111780012158	homotetramer interface [polypeptide binding]; other site
111780012159	active site
111780012160	homodimer interface [polypeptide binding]; other site
111780012161	Sporulation and spore germination; Region: Germane; pfam10646
111780012162	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
111780012163	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
111780012164	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
111780012165	carboxyltransferase (CT) interaction site; other site
111780012166	biotinylation site [posttranslational modification]; other site
111780012167	elongation factor P; Validated; Region: PRK00529
111780012168	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
111780012169	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
111780012170	RNA binding site [nucleotide binding]; other site
111780012171	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
111780012172	RNA binding site [nucleotide binding]; other site
111780012173	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
111780012174	active site
111780012175	thiamine monophosphate kinase; Provisional; Region: PRK05731
111780012176	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
111780012177	ATP binding site [chemical binding]; other site
111780012178	dimerization interface [polypeptide binding]; other site
111780012179	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780012180	GAF domain; Region: GAF; pfam01590
111780012181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012183	dimer interface [polypeptide binding]; other site
111780012184	phosphorylation site [posttranslational modification]
111780012185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012186	ATP binding site [chemical binding]; other site
111780012187	Mg2+ binding site [ion binding]; other site
111780012188	G-X-G motif; other site
111780012189	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
111780012190	ABC1 family; Region: ABC1; cl17513
111780012191	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
111780012192	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
111780012193	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
111780012194	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
111780012195	RNA binding site [nucleotide binding]; other site
111780012196	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
111780012197	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
111780012198	Surface antigen; Region: Bac_surface_Ag; pfam01103
111780012199	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
111780012200	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
111780012201	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
111780012202	NAD(P) binding site [chemical binding]; other site
111780012203	homodimer interface [polypeptide binding]; other site
111780012204	substrate binding site [chemical binding]; other site
111780012205	active site
111780012206	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780012207	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
111780012208	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
111780012209	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012210	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
111780012211	putative ADP-binding pocket [chemical binding]; other site
111780012212	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012213	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
111780012214	putative ADP-binding pocket [chemical binding]; other site
111780012215	O-Antigen ligase; Region: Wzy_C; pfam04932
111780012216	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
111780012217	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012218	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
111780012219	putative ADP-binding pocket [chemical binding]; other site
111780012220	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
111780012221	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
111780012222	putative ADP-binding pocket [chemical binding]; other site
111780012223	Bacterial sugar transferase; Region: Bac_transf; pfam02397
111780012224	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
111780012225	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
111780012226	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
111780012227	FemAB family; Region: FemAB; pfam02388
111780012228	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012229	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
111780012230	putative ADP-binding pocket [chemical binding]; other site
111780012231	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780012232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780012233	NAD(P) binding site [chemical binding]; other site
111780012234	active site
111780012235	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
111780012236	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
111780012237	Mg++ binding site [ion binding]; other site
111780012238	putative catalytic motif [active]
111780012239	putative substrate binding site [chemical binding]; other site
111780012240	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
111780012241	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
111780012242	inhibitor-cofactor binding pocket; inhibition site
111780012243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780012244	catalytic residue [active]
111780012245	Chain length determinant protein; Region: Wzz; pfam02706
111780012246	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
111780012247	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
111780012248	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
111780012249	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
111780012250	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
111780012251	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
111780012252	tetramer interface [polypeptide binding]; other site
111780012253	TPP-binding site [chemical binding]; other site
111780012254	heterodimer interface [polypeptide binding]; other site
111780012255	phosphorylation loop region [posttranslational modification]
111780012256	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
111780012257	putative active site [active]
111780012258	dimerization interface [polypeptide binding]; other site
111780012259	putative tRNAtyr binding site [nucleotide binding]; other site
111780012260	TPR repeat; Region: TPR_11; pfam13414
111780012261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012262	binding surface
111780012263	TPR motif; other site
111780012264	TPR repeat; Region: TPR_11; pfam13414
111780012265	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012266	binding surface
111780012267	TPR motif; other site
111780012268	TPR repeat; Region: TPR_11; pfam13414
111780012269	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012270	binding surface
111780012271	TPR motif; other site
111780012272	TPR repeat; Region: TPR_11; pfam13414
111780012273	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
111780012274	tetramerization interface [polypeptide binding]; other site
111780012275	active site
111780012276	S-layer homology domain; Region: SLH; pfam00395
111780012277	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780012278	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
111780012279	classical (c) SDRs; Region: SDR_c; cd05233
111780012280	NAD(P) binding site [chemical binding]; other site
111780012281	active site
111780012282	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
111780012283	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
111780012284	acyl-activating enzyme (AAE) consensus motif; other site
111780012285	AMP binding site [chemical binding]; other site
111780012286	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780012287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780012288	S-adenosylmethionine binding site [chemical binding]; other site
111780012289	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
111780012290	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
111780012291	thioester reductase domain; Region: Thioester-redct; TIGR01746
111780012292	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
111780012293	putative NAD(P) binding site [chemical binding]; other site
111780012294	active site
111780012295	putative substrate binding site [chemical binding]; other site
111780012296	Cache domain; Region: Cache_1; pfam02743
111780012297	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
111780012298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012299	dimer interface [polypeptide binding]; other site
111780012300	phosphorylation site [posttranslational modification]
111780012301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012302	ATP binding site [chemical binding]; other site
111780012303	Mg2+ binding site [ion binding]; other site
111780012304	G-X-G motif; other site
111780012305	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012307	active site
111780012308	phosphorylation site [posttranslational modification]
111780012309	intermolecular recognition site; other site
111780012310	dimerization interface [polypeptide binding]; other site
111780012311	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012313	active site
111780012314	phosphorylation site [posttranslational modification]
111780012315	intermolecular recognition site; other site
111780012316	dimerization interface [polypeptide binding]; other site
111780012317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012319	dimer interface [polypeptide binding]; other site
111780012320	phosphorylation site [posttranslational modification]
111780012321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012322	ATP binding site [chemical binding]; other site
111780012323	Mg2+ binding site [ion binding]; other site
111780012324	G-X-G motif; other site
111780012325	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012327	active site
111780012328	phosphorylation site [posttranslational modification]
111780012329	intermolecular recognition site; other site
111780012330	dimerization interface [polypeptide binding]; other site
111780012331	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780012332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012333	active site
111780012334	phosphorylation site [posttranslational modification]
111780012335	intermolecular recognition site; other site
111780012336	dimerization interface [polypeptide binding]; other site
111780012337	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780012338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012339	active site
111780012340	phosphorylation site [posttranslational modification]
111780012341	intermolecular recognition site; other site
111780012342	dimerization interface [polypeptide binding]; other site
111780012343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012344	dimer interface [polypeptide binding]; other site
111780012345	phosphorylation site [posttranslational modification]
111780012346	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012348	active site
111780012349	phosphorylation site [posttranslational modification]
111780012350	intermolecular recognition site; other site
111780012351	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
111780012352	dimerization interface [polypeptide binding]; other site
111780012353	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
111780012354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
111780012355	Uncharacterized conserved protein [Function unknown]; Region: COG5439
111780012356	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
111780012357	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
111780012358	Active Sites [active]
111780012359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012360	active site
111780012361	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012362	phosphorylation site [posttranslational modification]
111780012363	intermolecular recognition site; other site
111780012364	dimerization interface [polypeptide binding]; other site
111780012365	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012366	dimer interface [polypeptide binding]; other site
111780012367	phosphorylation site [posttranslational modification]
111780012368	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012369	ATP binding site [chemical binding]; other site
111780012370	Mg2+ binding site [ion binding]; other site
111780012371	G-X-G motif; other site
111780012372	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012374	active site
111780012375	phosphorylation site [posttranslational modification]
111780012376	intermolecular recognition site; other site
111780012377	dimerization interface [polypeptide binding]; other site
111780012378	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
111780012379	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780012380	Phytochrome region; Region: PHY; pfam00360
111780012381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012382	dimer interface [polypeptide binding]; other site
111780012383	phosphorylation site [posttranslational modification]
111780012384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012385	ATP binding site [chemical binding]; other site
111780012386	Mg2+ binding site [ion binding]; other site
111780012387	G-X-G motif; other site
111780012388	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
111780012389	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
111780012390	acyl-activating enzyme (AAE) consensus motif; other site
111780012391	putative AMP binding site [chemical binding]; other site
111780012392	putative active site [active]
111780012393	putative CoA binding site [chemical binding]; other site
111780012394	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
111780012395	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
111780012396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780012397	Probable transposase; Region: OrfB_IS605; pfam01385
111780012398	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780012399	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
111780012400	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
111780012401	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
111780012402	active site
111780012403	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
111780012404	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
111780012405	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
111780012406	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
111780012407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012409	dimer interface [polypeptide binding]; other site
111780012410	phosphorylation site [posttranslational modification]
111780012411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012412	ATP binding site [chemical binding]; other site
111780012413	Mg2+ binding site [ion binding]; other site
111780012414	G-X-G motif; other site
111780012415	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
111780012416	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
111780012417	active site
111780012418	Zn binding site [ion binding]; other site
111780012419	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
111780012420	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
111780012421	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
111780012422	Transcription initiation factor IIE; Region: TFIIE; smart00531
111780012423	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
111780012424	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
111780012425	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
111780012426	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
111780012427	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
111780012428	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
111780012429	metal-binding site [ion binding]
111780012430	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780012431	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780012432	motif II; other site
111780012433	tocopherol O-methyltransferase; Region: PLN02244
111780012434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780012435	S-adenosylmethionine binding site [chemical binding]; other site
111780012436	Uncharacterized conserved protein [Function unknown]; Region: COG3937
111780012437	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
111780012438	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
111780012439	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780012440	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
111780012441	active site
111780012442	catalytic triad [active]
111780012443	oxyanion hole [active]
111780012444	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
111780012445	DNA photolyase; Region: DNA_photolyase; pfam00875
111780012446	Protein of unknown function (DUF561); Region: DUF561; pfam04481
111780012447	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
111780012448	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
111780012449	inhibitor-cofactor binding pocket; inhibition site
111780012450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780012451	catalytic residue [active]
111780012452	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
111780012453	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780012454	putative active site [active]
111780012455	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
111780012456	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
111780012457	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
111780012458	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
111780012459	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012460	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012461	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012462	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012463	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012464	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012465	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012466	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
111780012467	Cna protein B-type domain; Region: Cna_B; pfam05738
111780012468	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
111780012469	putative metal binding site [ion binding]; other site
111780012470	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
111780012471	putative metal binding site [ion binding]; other site
111780012472	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
111780012473	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780012474	FeS/SAM binding site; other site
111780012475	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
111780012476	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
111780012477	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
111780012478	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780012479	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780012480	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
111780012481	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
111780012482	putative metal binding site [ion binding]; other site
111780012483	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
111780012484	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
111780012485	putative metal binding site [ion binding]; other site
111780012486	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
111780012487	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
111780012488	Uncharacterized conserved protein [Function unknown]; Region: COG0393
111780012489	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
111780012490	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
111780012491	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
111780012492	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
111780012493	Zn2+ binding site [ion binding]; other site
111780012494	Mg2+ binding site [ion binding]; other site
111780012495	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
111780012496	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
111780012497	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
111780012498	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
111780012499	FeS/SAM binding site; other site
111780012500	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
111780012501	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
111780012502	substrate binding site [chemical binding]; other site
111780012503	oxyanion hole (OAH) forming residues; other site
111780012504	trimer interface [polypeptide binding]; other site
111780012505	Protein of unknown function (DUF721); Region: DUF721; cl02324
111780012506	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
111780012507	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
111780012508	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
111780012509	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
111780012510	putative DNA binding site [nucleotide binding]; other site
111780012511	putative Zn2+ binding site [ion binding]; other site
111780012512	AsnC family; Region: AsnC_trans_reg; pfam01037
111780012513	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
111780012514	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
111780012515	dimer interface [polypeptide binding]; other site
111780012516	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
111780012517	active site
111780012518	Fe binding site [ion binding]; other site
111780012519	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
111780012520	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780012521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780012522	NAD(P) binding site [chemical binding]; other site
111780012523	active site
111780012524	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
111780012525	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
111780012526	substrate-cofactor binding pocket; other site
111780012527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780012528	catalytic residue [active]
111780012529	threonine dehydratase; Provisional; Region: PRK07334
111780012530	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
111780012531	tetramer interface [polypeptide binding]; other site
111780012532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780012533	catalytic residue [active]
111780012534	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
111780012535	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
111780012536	acetate--CoA ligase; Provisional; Region: PLN03052
111780012537	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
111780012538	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
111780012539	acyl-activating enzyme (AAE) consensus motif; other site
111780012540	AMP binding site [chemical binding]; other site
111780012541	active site
111780012542	CoA binding site [chemical binding]; other site
111780012543	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
111780012544	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
111780012545	dimer interface [polypeptide binding]; other site
111780012546	active site
111780012547	Biofilm formation and stress response factor; Region: BsmA; pfam10014
111780012548	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
111780012549	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
111780012550	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
111780012551	catalytic residue [active]
111780012552	fumarylacetoacetase; Region: PLN02856
111780012553	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
111780012554	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
111780012555	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
111780012556	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
111780012557	active site
111780012558	substrate binding pocket [chemical binding]; other site
111780012559	dimer interface [polypeptide binding]; other site
111780012560	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780012561	Major Facilitator Superfamily; Region: MFS_1; pfam07690
111780012562	putative substrate translocation pore; other site
111780012563	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
111780012564	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
111780012565	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
111780012566	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
111780012567	catalytic core [active]
111780012568	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
111780012569	DHH family; Region: DHH; pfam01368
111780012570	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
111780012571	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
111780012572	active site
111780012573	alanine racemase; Reviewed; Region: alr; PRK00053
111780012574	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
111780012575	active site
111780012576	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
111780012577	dimer interface [polypeptide binding]; other site
111780012578	substrate binding site [chemical binding]; other site
111780012579	catalytic residues [active]
111780012580	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
111780012581	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
111780012582	dimerization interface [polypeptide binding]; other site
111780012583	active site
111780012584	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780012585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012586	active site
111780012587	phosphorylation site [posttranslational modification]
111780012588	intermolecular recognition site; other site
111780012589	dimerization interface [polypeptide binding]; other site
111780012590	PAS fold; Region: PAS_7; pfam12860
111780012591	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
111780012592	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
111780012593	metal binding site [ion binding]; metal-binding site
111780012594	active site
111780012595	I-site; other site
111780012596	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
111780012597	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012599	active site
111780012600	phosphorylation site [posttranslational modification]
111780012601	intermolecular recognition site; other site
111780012602	dimerization interface [polypeptide binding]; other site
111780012603	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780012604	GAF domain; Region: GAF; pfam01590
111780012605	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012606	dimer interface [polypeptide binding]; other site
111780012607	phosphorylation site [posttranslational modification]
111780012608	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012610	ATP binding site [chemical binding]; other site
111780012611	Mg2+ binding site [ion binding]; other site
111780012612	G-X-G motif; other site
111780012613	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012614	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
111780012615	H+ Antiporter protein; Region: 2A0121; TIGR00900
111780012616	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
111780012617	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
111780012618	Recombination protein O N terminal; Region: RecO_N; pfam11967
111780012619	Recombination protein O C terminal; Region: RecO_C; pfam02565
111780012620	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
111780012621	intersubunit interface [polypeptide binding]; other site
111780012622	active site
111780012623	catalytic residue [active]
111780012624	hydrolase, alpha/beta fold family protein; Region: PLN02824
111780012625	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
111780012626	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
111780012627	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
111780012628	putative active site; other site
111780012629	catalytic residue [active]
111780012630	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
111780012631	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
111780012632	HEAT repeats; Region: HEAT_2; pfam13646
111780012633	HEAT repeats; Region: HEAT_2; pfam13646
111780012634	HEAT repeats; Region: HEAT_2; pfam13646
111780012635	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
111780012636	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
111780012637	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
111780012638	PYR/PP interface [polypeptide binding]; other site
111780012639	dimer interface [polypeptide binding]; other site
111780012640	TPP binding site [chemical binding]; other site
111780012641	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
111780012642	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
111780012643	TPP-binding site [chemical binding]; other site
111780012644	dimer interface [polypeptide binding]; other site
111780012645	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
111780012646	arogenate dehydrogenase; Reviewed; Region: PRK07417
111780012647	prephenate dehydrogenase; Validated; Region: PRK08507
111780012648	Ion channel; Region: Ion_trans_2; pfam07885
111780012649	Double zinc ribbon; Region: DZR; pfam12773
111780012650	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
111780012651	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
111780012652	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
111780012653	active site
111780012654	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
111780012655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780012656	binding surface
111780012657	TPR motif; other site
111780012658	Tetratricopeptide repeat; Region: TPR_9; pfam13371
111780012659	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
111780012660	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
111780012661	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
111780012662	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
111780012663	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
111780012664	DctM-like transporters; Region: DctM; pfam06808
111780012665	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
111780012666	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
111780012667	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
111780012668	active site
111780012669	Na/Ca binding site [ion binding]; other site
111780012670	catalytic site [active]
111780012671	Uncharacterized conserved protein [Function unknown]; Region: COG0432
111780012672	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780012673	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780012674	GUN4-like; Region: GUN4; pfam05419
111780012675	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780012676	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780012677	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
111780012678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780012679	S-adenosylmethionine binding site [chemical binding]; other site
111780012680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
111780012681	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
111780012682	diiron binding motif [ion binding]; other site
111780012683	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
111780012684	putative tRNA-binding site [nucleotide binding]; other site
111780012685	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
111780012686	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
111780012687	Ligand Binding Site [chemical binding]; other site
111780012688	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012690	dimer interface [polypeptide binding]; other site
111780012691	phosphorylation site [posttranslational modification]
111780012692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012693	ATP binding site [chemical binding]; other site
111780012694	Mg2+ binding site [ion binding]; other site
111780012695	G-X-G motif; other site
111780012696	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
111780012697	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
111780012698	active site
111780012699	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
111780012700	putative active site [active]
111780012701	putative metal binding residues [ion binding]; other site
111780012702	signature motif; other site
111780012703	putative dimer interface [polypeptide binding]; other site
111780012704	putative phosphate binding site [ion binding]; other site
111780012705	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
111780012706	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
111780012707	active site
111780012708	catalytic site [active]
111780012709	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
111780012710	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
111780012711	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
111780012712	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
111780012713	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
111780012714	16S/18S rRNA binding site [nucleotide binding]; other site
111780012715	S13e-L30e interaction site [polypeptide binding]; other site
111780012716	25S rRNA binding site [nucleotide binding]; other site
111780012717	Domain of unknown function DUF29; Region: DUF29; pfam01724
111780012718	flavoprotein, HI0933 family; Region: TIGR00275
111780012719	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
111780012720	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
111780012721	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
111780012722	argininosuccinate synthase; Provisional; Region: PRK13820
111780012723	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
111780012724	ANP binding site [chemical binding]; other site
111780012725	Substrate Binding Site II [chemical binding]; other site
111780012726	Substrate Binding Site I [chemical binding]; other site
111780012727	tartrate dehydrogenase; Region: TTC; TIGR02089
111780012728	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
111780012729	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
111780012730	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
111780012731	nucleotide binding pocket [chemical binding]; other site
111780012732	K-X-D-G motif; other site
111780012733	catalytic site [active]
111780012734	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
111780012735	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
111780012736	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
111780012737	Dimer interface [polypeptide binding]; other site
111780012738	BRCT sequence motif; other site
111780012739	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
111780012740	putative FMN binding site [chemical binding]; other site
111780012741	response regulator FixJ; Provisional; Region: fixJ; PRK09390
111780012742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012743	active site
111780012744	phosphorylation site [posttranslational modification]
111780012745	intermolecular recognition site; other site
111780012746	dimerization interface [polypeptide binding]; other site
111780012747	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780012748	DNA binding residues [nucleotide binding]
111780012749	dimerization interface [polypeptide binding]; other site
111780012750	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
111780012751	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
111780012752	ring oligomerisation interface [polypeptide binding]; other site
111780012753	ATP/Mg binding site [chemical binding]; other site
111780012754	stacking interactions; other site
111780012755	hinge regions; other site
111780012756	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
111780012757	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780012758	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
111780012759	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
111780012760	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
111780012761	Acylphosphatase; Region: Acylphosphatase; pfam00708
111780012762	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
111780012763	Part of AAA domain; Region: AAA_19; pfam13245
111780012764	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
111780012765	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
111780012766	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
111780012767	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780012768	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012769	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012770	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780012771	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012772	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012773	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780012774	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012775	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
111780012776	PemK-like protein; Region: PemK; pfam02452
111780012777	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
111780012778	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
111780012779	Protein of unknown function, DUF608; Region: DUF608; pfam04685
111780012780	GXWXG protein; Region: GXWXG; pfam14231
111780012781	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
111780012782	tellurite resistance protein terB; Region: terB; cd07176
111780012783	putative metal binding site [ion binding]; other site
111780012784	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
111780012785	oligomeric interface; other site
111780012786	putative active site [active]
111780012787	homodimer interface [polypeptide binding]; other site
111780012788	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
111780012789	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
111780012790	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
111780012791	substrate binding pocket [chemical binding]; other site
111780012792	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
111780012793	B12 binding site [chemical binding]; other site
111780012794	cobalt ligand [ion binding]; other site
111780012795	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
111780012796	Domain of unknown function DUF20; Region: UPF0118; pfam01594
111780012797	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
111780012798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780012799	binding surface
111780012800	TPR motif; other site
111780012801	TPR repeat; Region: TPR_11; pfam13414
111780012802	Uncharacterized conserved protein [Function unknown]; Region: COG0398
111780012803	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
111780012804	mercuric reductase; Validated; Region: PRK06370
111780012805	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
111780012806	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780012807	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
111780012808	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
111780012809	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
111780012810	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
111780012811	Domain of unknown function DUF59; Region: DUF59; pfam01883
111780012812	antiporter inner membrane protein; Provisional; Region: PRK11670
111780012813	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
111780012814	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
111780012815	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
111780012816	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
111780012817	homodimer interface [polypeptide binding]; other site
111780012818	substrate-cofactor binding pocket; other site
111780012819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
111780012820	catalytic residue [active]
111780012821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
111780012822	Protein of unknown function (DUF433); Region: DUF433; pfam04255
111780012823	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
111780012824	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
111780012825	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
111780012826	ribosomal protein L21; Region: rpl21; CHL00075
111780012827	chaperone protein DnaJ; Provisional; Region: PRK14299
111780012828	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780012829	HSP70 interaction site [polypeptide binding]; other site
111780012830	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
111780012831	substrate binding site [polypeptide binding]; other site
111780012832	dimer interface [polypeptide binding]; other site
111780012833	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
111780012834	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
111780012835	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780012836	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
111780012837	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
111780012838	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
111780012839	TrkA-N domain; Region: TrkA_N; pfam02254
111780012840	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
111780012841	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
111780012842	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
111780012843	Predicted transcriptional regulator [Transcription]; Region: COG1959
111780012844	Transcriptional regulator; Region: Rrf2; cl17282
111780012845	Uncharacterized conserved protein [Function unknown]; Region: COG3791
111780012846	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
111780012847	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780012848	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780012849	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780012850	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780012851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
111780012852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780012853	dimer interface [polypeptide binding]; other site
111780012854	phosphorylation site [posttranslational modification]
111780012855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012856	ATP binding site [chemical binding]; other site
111780012857	Mg2+ binding site [ion binding]; other site
111780012858	G-X-G motif; other site
111780012859	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
111780012860	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012861	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012862	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012863	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012864	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012865	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012866	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780012867	putative active site [active]
111780012868	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
111780012869	DNA methylase; Region: N6_N4_Mtase; pfam01555
111780012870	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
111780012871	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
111780012872	cofactor binding site; other site
111780012873	DNA binding site [nucleotide binding]
111780012874	substrate interaction site [chemical binding]; other site
111780012875	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780012876	Ligand Binding Site [chemical binding]; other site
111780012877	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780012878	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012879	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780012880	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
111780012881	substrate binding site [chemical binding]; other site
111780012882	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
111780012883	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
111780012884	substrate binding site [chemical binding]; other site
111780012885	ligand binding site [chemical binding]; other site
111780012886	Cupin domain; Region: Cupin_2; pfam07883
111780012887	Predicted transcriptional regulators [Transcription]; Region: COG1733
111780012888	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
111780012889	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
111780012890	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
111780012891	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
111780012892	C-terminal domain interface [polypeptide binding]; other site
111780012893	GSH binding site (G-site) [chemical binding]; other site
111780012894	dimer interface [polypeptide binding]; other site
111780012895	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
111780012896	substrate binding pocket (H-site) [chemical binding]; other site
111780012897	N-terminal domain interface [polypeptide binding]; other site
111780012898	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
111780012899	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
111780012900	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
111780012901	NAD binding site [chemical binding]; other site
111780012902	substrate binding site [chemical binding]; other site
111780012903	active site
111780012904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
111780012905	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
111780012906	Family of unknown function (DUF490); Region: DUF490; pfam04357
111780012907	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
111780012908	Protein of unknown function (DUF554); Region: DUF554; pfam04474
111780012909	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
111780012910	5' RNA guide strand anchoring site; other site
111780012911	active site
111780012912	Transposase IS200 like; Region: Y1_Tnp; cl00848
111780012913	magnesium chelatase subunit H; Provisional; Region: PRK12493
111780012914	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
111780012915	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
111780012916	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
111780012917	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
111780012918	catalytic triad [active]
111780012919	phosphoribulokinase; Provisional; Region: PRK07429
111780012920	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
111780012921	active site
111780012922	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780012923	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780012924	putative binding surface; other site
111780012925	active site
111780012926	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780012927	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
111780012928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012929	ATP binding site [chemical binding]; other site
111780012930	Mg2+ binding site [ion binding]; other site
111780012931	G-X-G motif; other site
111780012932	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780012933	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780012934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012935	active site
111780012936	phosphorylation site [posttranslational modification]
111780012937	intermolecular recognition site; other site
111780012938	dimerization interface [polypeptide binding]; other site
111780012939	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780012940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012941	active site
111780012942	phosphorylation site [posttranslational modification]
111780012943	intermolecular recognition site; other site
111780012944	dimerization interface [polypeptide binding]; other site
111780012945	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780012946	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780012947	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
111780012948	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780012949	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780012950	dimer interface [polypeptide binding]; other site
111780012951	putative CheW interface [polypeptide binding]; other site
111780012952	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780012953	dimerization interface [polypeptide binding]; other site
111780012954	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780012955	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780012956	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780012957	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780012958	dimer interface [polypeptide binding]; other site
111780012959	putative CheW interface [polypeptide binding]; other site
111780012960	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780012961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012962	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012963	active site
111780012964	phosphorylation site [posttranslational modification]
111780012965	intermolecular recognition site; other site
111780012966	dimerization interface [polypeptide binding]; other site
111780012967	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
111780012968	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012970	active site
111780012971	phosphorylation site [posttranslational modification]
111780012972	intermolecular recognition site; other site
111780012973	dimerization interface [polypeptide binding]; other site
111780012974	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
111780012975	dimerization interface [polypeptide binding]; other site
111780012976	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780012977	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780012978	dimer interface [polypeptide binding]; other site
111780012979	putative CheW interface [polypeptide binding]; other site
111780012980	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
111780012981	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
111780012982	putative binding surface; other site
111780012983	active site
111780012984	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
111780012985	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
111780012986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780012987	ATP binding site [chemical binding]; other site
111780012988	Mg2+ binding site [ion binding]; other site
111780012989	G-X-G motif; other site
111780012990	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
111780012991	Response regulator receiver domain; Region: Response_reg; pfam00072
111780012992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780012993	active site
111780012994	phosphorylation site [posttranslational modification]
111780012995	intermolecular recognition site; other site
111780012996	dimerization interface [polypeptide binding]; other site
111780012997	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
111780012998	dimerization interface [polypeptide binding]; other site
111780012999	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
111780013000	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
111780013001	dimer interface [polypeptide binding]; other site
111780013002	putative CheW interface [polypeptide binding]; other site
111780013003	Response regulator receiver domain; Region: Response_reg; pfam00072
111780013004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013005	active site
111780013006	phosphorylation site [posttranslational modification]
111780013007	intermolecular recognition site; other site
111780013008	dimerization interface [polypeptide binding]; other site
111780013009	Response regulator receiver domain; Region: Response_reg; pfam00072
111780013010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013011	active site
111780013012	phosphorylation site [posttranslational modification]
111780013013	intermolecular recognition site; other site
111780013014	dimerization interface [polypeptide binding]; other site
111780013015	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
111780013016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013017	active site
111780013018	phosphorylation site [posttranslational modification]
111780013019	intermolecular recognition site; other site
111780013020	dimerization interface [polypeptide binding]; other site
111780013021	ParB-like nuclease domain; Region: ParBc; cl02129
111780013022	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
111780013023	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
111780013024	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
111780013025	photosystem II reaction center protein J; Provisional; Region: PRK02565
111780013026	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
111780013027	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
111780013028	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
111780013029	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
111780013030	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
111780013031	Ycf48-like protein; Provisional; Region: PRK13684
111780013032	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
111780013033	Rubredoxin; Region: Rubredoxin; pfam00301
111780013034	iron binding site [ion binding]; other site
111780013035	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
111780013036	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
111780013037	hinge; other site
111780013038	active site
111780013039	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
111780013040	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
111780013041	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
111780013042	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
111780013043	polyphosphate kinase; Provisional; Region: PRK05443
111780013044	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
111780013045	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
111780013046	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
111780013047	putative domain interface [polypeptide binding]; other site
111780013048	putative active site [active]
111780013049	catalytic site [active]
111780013050	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
111780013051	putative domain interface [polypeptide binding]; other site
111780013052	putative active site [active]
111780013053	catalytic site [active]
111780013054	Response regulator receiver domain; Region: Response_reg; pfam00072
111780013055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013056	active site
111780013057	phosphorylation site [posttranslational modification]
111780013058	intermolecular recognition site; other site
111780013059	dimerization interface [polypeptide binding]; other site
111780013060	light-harvesting-like protein 3; Provisional; Region: PLN00014
111780013061	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780013062	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
111780013063	M28 Zn-Peptidases; Region: M28_like_1; cd05640
111780013064	Peptidase family M28; Region: Peptidase_M28; pfam04389
111780013065	metal binding site [ion binding]; metal-binding site
111780013066	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
111780013067	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
111780013068	DNA binding site [nucleotide binding]
111780013069	catalytic residue [active]
111780013070	H2TH interface [polypeptide binding]; other site
111780013071	putative catalytic residues [active]
111780013072	turnover-facilitating residue; other site
111780013073	intercalation triad [nucleotide binding]; other site
111780013074	8OG recognition residue [nucleotide binding]; other site
111780013075	putative reading head residues; other site
111780013076	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
111780013077	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
111780013078	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
111780013079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
111780013080	Coenzyme A binding pocket [chemical binding]; other site
111780013081	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
111780013082	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
111780013083	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
111780013084	Surface antigen; Region: Bac_surface_Ag; pfam01103
111780013085	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
111780013086	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
111780013087	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
111780013088	oligomeric interface; other site
111780013089	homodimer interface [polypeptide binding]; other site
111780013090	putative active site [active]
111780013091	Helix-turn-helix domain; Region: HTH_17; pfam12728
111780013092	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780013093	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780013094	Tetratricopeptide repeat; Region: TPR_12; pfam13424
111780013095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
111780013096	TPR motif; other site
111780013097	binding surface
111780013098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
111780013099	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
111780013100	Helix-turn-helix domain; Region: HTH_37; pfam13744
111780013101	non-specific DNA binding site [nucleotide binding]; other site
111780013102	salt bridge; other site
111780013103	sequence-specific DNA binding site [nucleotide binding]; other site
111780013104	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
111780013105	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
111780013106	CHASE2 domain; Region: CHASE2; pfam05226
111780013107	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
111780013108	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
111780013109	ATP binding site [chemical binding]; other site
111780013110	Mg2+ binding site [ion binding]; other site
111780013111	G-X-G motif; other site
111780013112	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780013113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013114	active site
111780013115	phosphorylation site [posttranslational modification]
111780013116	intermolecular recognition site; other site
111780013117	dimerization interface [polypeptide binding]; other site
111780013118	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
111780013119	putative chaperone; Provisional; Region: PRK11678
111780013120	nucleotide binding site [chemical binding]; other site
111780013121	putative NEF/HSP70 interaction site [polypeptide binding]; other site
111780013122	SBD interface [polypeptide binding]; other site
111780013123	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
111780013124	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780013125	active site
111780013126	ATP binding site [chemical binding]; other site
111780013127	substrate binding site [chemical binding]; other site
111780013128	activation loop (A-loop); other site
111780013129	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013130	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013131	structural tetrad; other site
111780013132	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780013133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780013134	Probable transposase; Region: OrfB_IS605; pfam01385
111780013135	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780013136	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
111780013137	Dynamin family; Region: Dynamin_N; pfam00350
111780013138	G1 box; other site
111780013139	GTP/Mg2+ binding site [chemical binding]; other site
111780013140	G2 box; other site
111780013141	Switch I region; other site
111780013142	G3 box; other site
111780013143	Switch II region; other site
111780013144	G4 box; other site
111780013145	G5 box; other site
111780013146	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
111780013147	Dynamin family; Region: Dynamin_N; pfam00350
111780013148	G1 box; other site
111780013149	GTP/Mg2+ binding site [chemical binding]; other site
111780013150	G2 box; other site
111780013151	Switch I region; other site
111780013152	G3 box; other site
111780013153	Switch II region; other site
111780013154	G4 box; other site
111780013155	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
111780013156	dimer interface [polypeptide binding]; other site
111780013157	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
111780013158	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780013159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013160	active site
111780013161	phosphorylation site [posttranslational modification]
111780013162	intermolecular recognition site; other site
111780013163	dimerization interface [polypeptide binding]; other site
111780013164	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
111780013165	DNA binding residues [nucleotide binding]
111780013166	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
111780013167	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
111780013168	nucleotide binding site [chemical binding]; other site
111780013169	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
111780013170	active site
111780013171	catalytic residues [active]
111780013172	metal binding site [ion binding]; metal-binding site
111780013173	ParA-like protein; Provisional; Region: PHA02518
111780013174	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013175	P-loop; other site
111780013176	Magnesium ion binding site [ion binding]; other site
111780013177	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
111780013178	ParB-like nuclease domain; Region: ParB; smart00470
111780013179	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
111780013180	LabA_like proteins; Region: LabA_like; cd06167
111780013181	putative metal binding site [ion binding]; other site
111780013182	Predicted flavoprotein [General function prediction only]; Region: COG0431
111780013183	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
111780013184	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
111780013185	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
111780013186	catalytic residues [active]
111780013187	catalytic nucleophile [active]
111780013188	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
111780013189	Homeodomain-like domain; Region: HTH_23; cl17451
111780013190	Winged helix-turn helix; Region: HTH_29; pfam13551
111780013191	Homeodomain-like domain; Region: HTH_32; pfam13565
111780013192	Integrase core domain; Region: rve; pfam00665
111780013193	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
111780013194	multiple promoter invertase; Provisional; Region: mpi; PRK13413
111780013195	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
111780013196	catalytic residues [active]
111780013197	catalytic nucleophile [active]
111780013198	Presynaptic Site I dimer interface [polypeptide binding]; other site
111780013199	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
111780013200	Synaptic Flat tetramer interface [polypeptide binding]; other site
111780013201	Synaptic Site I dimer interface [polypeptide binding]; other site
111780013202	DNA binding site [nucleotide binding]
111780013203	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
111780013204	DNA-binding interface [nucleotide binding]; DNA binding site
111780013205	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780013206	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
111780013207	phosphopeptide binding site; other site
111780013208	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780013209	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780013210	active site
111780013211	ATP binding site [chemical binding]; other site
111780013212	substrate binding site [chemical binding]; other site
111780013213	activation loop (A-loop); other site
111780013214	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780013215	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780013216	active site
111780013217	ATP binding site [chemical binding]; other site
111780013218	substrate binding site [chemical binding]; other site
111780013219	activation loop (A-loop); other site
111780013220	Protein kinase domain; Region: Pkinase; pfam00069
111780013221	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780013222	active site
111780013223	ATP binding site [chemical binding]; other site
111780013224	substrate binding site [chemical binding]; other site
111780013225	activation loop (A-loop); other site
111780013226	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
111780013227	Uncharacterized conserved protein [Function unknown]; Region: COG1262
111780013228	Caspase domain; Region: Peptidase_C14; pfam00656
111780013229	WD domain, G-beta repeat; Region: WD40; pfam00400
111780013230	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013231	structural tetrad; other site
111780013232	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013233	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013234	structural tetrad; other site
111780013235	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
111780013236	Protein of unknown function (DUF497); Region: DUF497; cl01108
111780013237	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
111780013238	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
111780013239	YcfA-like protein; Region: YcfA; pfam07927
111780013240	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
111780013241	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
111780013242	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
111780013243	AAA ATPase domain; Region: AAA_16; pfam13191
111780013244	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013245	structural tetrad; other site
111780013246	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013247	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013248	structural tetrad; other site
111780013249	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
111780013250	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013251	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013252	structural tetrad; other site
111780013253	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
111780013254	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
111780013255	HSP70 interaction site [polypeptide binding]; other site
111780013256	TPR repeat; Region: TPR_11; pfam13414
111780013257	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
111780013258	metal ion-dependent adhesion site (MIDAS); other site
111780013259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
111780013260	DNA adenine methylase (dam); Region: dam; TIGR00571
111780013261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
111780013262	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
111780013263	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
111780013264	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
111780013265	active site
111780013266	catalytic site [active]
111780013267	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
111780013268	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780013269	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
111780013270	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
111780013271	active site
111780013272	substrate binding site [chemical binding]; other site
111780013273	Mg2+ binding site [ion binding]; other site
111780013274	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
111780013275	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
111780013276	active site
111780013277	Transcriptional regulator [Transcription]; Region: LysR; COG0583
111780013278	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
111780013279	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
111780013280	putative effector binding pocket; other site
111780013281	dimerization interface [polypeptide binding]; other site
111780013282	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
111780013283	NmrA-like family; Region: NmrA; pfam05368
111780013284	NADP binding site [chemical binding]; other site
111780013285	active site
111780013286	regulatory binding site [polypeptide binding]; other site
111780013287	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
111780013288	NADH(P)-binding; Region: NAD_binding_10; pfam13460
111780013289	NAD binding site [chemical binding]; other site
111780013290	substrate binding site [chemical binding]; other site
111780013291	putative active site [active]
111780013292	ParB-like nuclease domain; Region: ParBc; pfam02195
111780013293	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
111780013294	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013295	P-loop; other site
111780013296	Magnesium ion binding site [ion binding]; other site
111780013297	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013298	Magnesium ion binding site [ion binding]; other site
111780013299	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
111780013300	catalytic triad [active]
111780013301	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
111780013302	oligomeric interface; other site
111780013303	putative active site [active]
111780013304	homodimer interface [polypeptide binding]; other site
111780013305	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
111780013306	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
111780013307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780013308	non-specific DNA binding site [nucleotide binding]; other site
111780013309	salt bridge; other site
111780013310	sequence-specific DNA binding site [nucleotide binding]; other site
111780013311	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
111780013312	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780013313	active site
111780013314	DNA binding site [nucleotide binding]
111780013315	Int/Topo IB signature motif; other site
111780013316	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
111780013317	protein binding site [polypeptide binding]; other site
111780013318	CHAT domain; Region: CHAT; pfam12770
111780013319	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
111780013320	Uncharacterized conserved protein [Function unknown]; Region: COG4278
111780013321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780013322	S-adenosylmethionine binding site [chemical binding]; other site
111780013323	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
111780013324	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
111780013325	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
111780013326	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
111780013327	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
111780013328	Winged helix-turn helix; Region: HTH_29; pfam13551
111780013329	Winged helix-turn helix; Region: HTH_33; pfam13592
111780013330	DDE superfamily endonuclease; Region: DDE_3; pfam13358
111780013331	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
111780013332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780013333	non-specific DNA binding site [nucleotide binding]; other site
111780013334	salt bridge; other site
111780013335	sequence-specific DNA binding site [nucleotide binding]; other site
111780013336	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
111780013337	protein-splicing catalytic site; other site
111780013338	thioester formation/cholesterol transfer; other site
111780013339	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
111780013340	active site
111780013341	metal binding site [ion binding]; metal-binding site
111780013342	D5 N terminal like; Region: D5_N; pfam08706
111780013343	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
111780013344	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
111780013345	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
111780013346	protein-splicing catalytic site; other site
111780013347	thioester formation/cholesterol transfer; other site
111780013348	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
111780013349	Family description; Region: UvrD_C_2; pfam13538
111780013350	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
111780013351	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013352	P-loop; other site
111780013353	Magnesium ion binding site [ion binding]; other site
111780013354	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013355	Magnesium ion binding site [ion binding]; other site
111780013356	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
111780013357	ParB-like nuclease domain; Region: ParB; smart00470
111780013358	WGR domain; Region: WGR; cl01581
111780013359	Septin; Region: Septin; pfam00735
111780013360	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780013361	AAA domain; Region: AAA_22; pfam13401
111780013362	Walker A motif; other site
111780013363	ATP binding site [chemical binding]; other site
111780013364	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
111780013365	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
111780013366	HerA helicase [Replication, recombination, and repair]; Region: COG0433
111780013367	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
111780013368	GIY-YIG motif/motif A; other site
111780013369	active site
111780013370	catalytic site [active]
111780013371	metal binding site [ion binding]; metal-binding site
111780013372	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
111780013373	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
111780013374	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780013375	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
111780013376	active site
111780013377	DNA binding site [nucleotide binding]
111780013378	Int/Topo IB signature motif; other site
111780013379	Staphylococcal nuclease homologues; Region: SNc; smart00318
111780013380	Catalytic site; other site
111780013381	Staphylococcal nuclease homologue; Region: SNase; pfam00565
111780013382	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
111780013383	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780013384	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780013385	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
111780013386	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
111780013387	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
111780013388	DNA binding residues [nucleotide binding]
111780013389	dimer interface [polypeptide binding]; other site
111780013390	Membrane transport protein MerF; Region: Transport_MerF; pfam11431
111780013391	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780013392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780013393	S-adenosylmethionine binding site [chemical binding]; other site
111780013394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780013395	dimer interface [polypeptide binding]; other site
111780013396	phosphorylation site [posttranslational modification]
111780013397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780013398	ATP binding site [chemical binding]; other site
111780013399	Mg2+ binding site [ion binding]; other site
111780013400	G-X-G motif; other site
111780013401	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780013402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013403	active site
111780013404	phosphorylation site [posttranslational modification]
111780013405	intermolecular recognition site; other site
111780013406	dimerization interface [polypeptide binding]; other site
111780013407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780013408	DNA binding site [nucleotide binding]
111780013409	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
111780013410	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
111780013411	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780013412	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780013413	YtkA-like; Region: YtkA; pfam13115
111780013414	YtkA-like; Region: YtkA; pfam13115
111780013415	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
111780013416	Methyltransferase domain; Region: Methyltransf_23; pfam13489
111780013417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780013418	S-adenosylmethionine binding site [chemical binding]; other site
111780013419	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780013420	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
111780013421	Multicopper oxidase; Region: Cu-oxidase; pfam00394
111780013422	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780013423	Predicted metal-binding protein [General function prediction only]; Region: COG3019
111780013424	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
111780013425	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
111780013426	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
111780013427	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780013428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013429	active site
111780013430	phosphorylation site [posttranslational modification]
111780013431	intermolecular recognition site; other site
111780013432	dimerization interface [polypeptide binding]; other site
111780013433	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780013434	DNA binding site [nucleotide binding]
111780013435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780013436	dimer interface [polypeptide binding]; other site
111780013437	phosphorylation site [posttranslational modification]
111780013438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780013439	ATP binding site [chemical binding]; other site
111780013440	Mg2+ binding site [ion binding]; other site
111780013441	G-X-G motif; other site
111780013442	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
111780013443	putative active site [active]
111780013444	EamA-like transporter family; Region: EamA; pfam00892
111780013445	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
111780013446	EamA-like transporter family; Region: EamA; pfam00892
111780013447	CAAX protease self-immunity; Region: Abi; pfam02517
111780013448	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780013449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013450	binding surface
111780013451	TPR motif; other site
111780013452	TPR repeat; Region: TPR_11; pfam13414
111780013453	TPR repeat; Region: TPR_11; pfam13414
111780013454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013455	binding surface
111780013456	TPR motif; other site
111780013457	TPR repeat; Region: TPR_11; pfam13414
111780013458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013459	binding surface
111780013460	TPR motif; other site
111780013461	TPR repeat; Region: TPR_11; pfam13414
111780013462	hypothetical protein; Provisional; Region: PRK02237
111780013463	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
111780013464	putative active site [active]
111780013465	substrate binding site [chemical binding]; other site
111780013466	redox center [active]
111780013467	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
111780013468	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
111780013469	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780013470	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
111780013471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
111780013472	dimerization interface [polypeptide binding]; other site
111780013473	putative DNA binding site [nucleotide binding]; other site
111780013474	putative Zn2+ binding site [ion binding]; other site
111780013475	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
111780013476	Methylamine utilisation protein MauE; Region: MauE; pfam07291
111780013477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780013478	dimer interface [polypeptide binding]; other site
111780013479	phosphorylation site [posttranslational modification]
111780013480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780013481	ATP binding site [chemical binding]; other site
111780013482	Mg2+ binding site [ion binding]; other site
111780013483	G-X-G motif; other site
111780013484	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780013485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013486	active site
111780013487	phosphorylation site [posttranslational modification]
111780013488	intermolecular recognition site; other site
111780013489	dimerization interface [polypeptide binding]; other site
111780013490	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780013491	DNA binding site [nucleotide binding]
111780013492	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
111780013493	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
111780013494	HlyD family secretion protein; Region: HlyD_3; pfam13437
111780013495	YtkA-like; Region: YtkA; pfam13115
111780013496	YtkA-like; Region: YtkA; pfam13115
111780013497	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
111780013498	Predicted metal-binding protein [General function prediction only]; Region: COG3019
111780013499	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
111780013500	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780013501	Multicopper oxidase; Region: Cu-oxidase; pfam00394
111780013502	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780013503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
111780013504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780013505	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780013506	Probable transposase; Region: OrfB_IS605; pfam01385
111780013507	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
111780013508	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
111780013509	DNA binding residues [nucleotide binding]
111780013510	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
111780013511	catalytic residues [active]
111780013512	catalytic nucleophile [active]
111780013513	RES domain; Region: RES; pfam08808
111780013514	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780013515	active site
111780013516	Int/Topo IB signature motif; other site
111780013517	DNA binding site [nucleotide binding]
111780013518	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
111780013519	RRXRR protein; Region: RRXRR; pfam14239
111780013520	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
111780013521	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013522	P-loop; other site
111780013523	Magnesium ion binding site [ion binding]; other site
111780013524	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780013525	Magnesium ion binding site [ion binding]; other site
111780013526	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
111780013527	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
111780013528	ATP binding site [chemical binding]; other site
111780013529	substrate interface [chemical binding]; other site
111780013530	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
111780013531	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
111780013532	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
111780013533	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
111780013534	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
111780013535	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
111780013536	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
111780013537	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
111780013538	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
111780013539	Protein of unknown function (DUF433); Region: DUF433; cl01030
111780013540	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
111780013541	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
111780013542	Protein of unknown function (DUF433); Region: DUF433; pfam04255
111780013543	WYL domain; Region: WYL; pfam13280
111780013544	AAA-like domain; Region: AAA_10; pfam12846
111780013545	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
111780013546	active site
111780013547	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
111780013548	RHS Repeat; Region: RHS_repeat; pfam05593
111780013549	RHS Repeat; Region: RHS_repeat; pfam05593
111780013550	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
111780013551	RHS Repeat; Region: RHS_repeat; pfam05593
111780013552	RHS Repeat; Region: RHS_repeat; pfam05593
111780013553	RHS Repeat; Region: RHS_repeat; pfam05593
111780013554	RHS Repeat; Region: RHS_repeat; pfam05593
111780013555	RHS Repeat; Region: RHS_repeat; pfam05593
111780013556	RHS Repeat; Region: RHS_repeat; pfam05593
111780013557	RHS Repeat; Region: RHS_repeat; cl11982
111780013558	RHS Repeat; Region: RHS_repeat; pfam05593
111780013559	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
111780013560	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
111780013561	Fe-S cluster binding site [ion binding]; other site
111780013562	active site
111780013563	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
111780013564	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780013565	non-specific DNA binding site [nucleotide binding]; other site
111780013566	salt bridge; other site
111780013567	sequence-specific DNA binding site [nucleotide binding]; other site
111780013568	AAA domain; Region: AAA_11; pfam13086
111780013569	AAA domain; Region: AAA_30; pfam13604
111780013570	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
111780013571	DNA polymerase III subunit beta; Validated; Region: PRK05643
111780013572	putative DNA binding surface [nucleotide binding]; other site
111780013573	dimer interface [polypeptide binding]; other site
111780013574	beta-clamp/translesion DNA polymerase binding surface; other site
111780013575	beta-clamp/clamp loader binding surface; other site
111780013576	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
111780013577	replicative DNA helicase; Region: DnaB; TIGR00665
111780013578	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
111780013579	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
111780013580	Walker A motif; other site
111780013581	ATP binding site [chemical binding]; other site
111780013582	Walker B motif; other site
111780013583	DNA binding loops [nucleotide binding]
111780013584	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
111780013585	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780013586	active site
111780013587	DNA binding site [nucleotide binding]
111780013588	Int/Topo IB signature motif; other site
111780013589	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
111780013590	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
111780013591	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780013592	active site
111780013593	DNA binding site [nucleotide binding]
111780013594	Int/Topo IB signature motif; other site
111780013595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780013596	Probable transposase; Region: OrfB_IS605; pfam01385
111780013597	Transposase IS200 like; Region: Y1_Tnp; pfam01797
111780013598	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
111780013599	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
111780013600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780013601	Walker A motif; other site
111780013602	ATP binding site [chemical binding]; other site
111780013603	Walker B motif; other site
111780013604	arginine finger; other site
111780013605	DNA polymerase III subunit delta; Validated; Region: PRK07452
111780013606	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
111780013607	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
111780013608	DNA binding residues [nucleotide binding]
111780013609	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780013610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013611	active site
111780013612	phosphorylation site [posttranslational modification]
111780013613	intermolecular recognition site; other site
111780013614	dimerization interface [polypeptide binding]; other site
111780013615	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780013616	DNA binding residues [nucleotide binding]
111780013617	dimerization interface [polypeptide binding]; other site
111780013618	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
111780013619	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
111780013620	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
111780013621	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
111780013622	active site
111780013623	catalytic site [active]
111780013624	substrate binding site [chemical binding]; other site
111780013625	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
111780013626	active site
111780013627	DNA binding site [nucleotide binding]
111780013628	catalytic site [active]
111780013629	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
111780013630	PemK-like protein; Region: PemK; pfam02452
111780013631	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
111780013632	metal ion-dependent adhesion site (MIDAS); other site
111780013633	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
111780013634	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
111780013635	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780013636	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
111780013637	Catalytic domain of Protein Kinases; Region: PKc; cd00180
111780013638	active site
111780013639	ATP binding site [chemical binding]; other site
111780013640	substrate binding site [chemical binding]; other site
111780013641	activation loop (A-loop); other site
111780013642	GUN4-like; Region: GUN4; pfam05419
111780013643	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780013644	putative active site [active]
111780013645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780013646	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780013647	Probable transposase; Region: OrfB_IS605; pfam01385
111780013648	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780013649	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
111780013650	phosphopeptide binding site; other site
111780013651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780013652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
111780013653	DNA binding site [nucleotide binding]
111780013654	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780013655	Circadian oscillating protein COP23; Region: COP23; pfam14218
111780013656	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780013657	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
111780013658	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
111780013659	TPR repeat; Region: TPR_11; pfam13414
111780013660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013661	binding surface
111780013662	TPR motif; other site
111780013663	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780013664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013665	TPR motif; other site
111780013666	binding surface
111780013667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013668	binding surface
111780013669	TPR motif; other site
111780013670	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
111780013671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013672	binding surface
111780013673	TPR motif; other site
111780013674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013675	binding surface
111780013676	TPR motif; other site
111780013677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
111780013678	binding surface
111780013679	TPR motif; other site
111780013680	Tetratricopeptide repeat; Region: TPR_16; pfam13432
111780013681	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
111780013682	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
111780013683	active site
111780013684	NTP binding site [chemical binding]; other site
111780013685	metal binding triad [ion binding]; metal-binding site
111780013686	antibiotic binding site [chemical binding]; other site
111780013687	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780013688	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780013689	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780013690	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
111780013691	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
111780013692	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
111780013693	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
111780013694	putative ligand binding site [chemical binding]; other site
111780013695	CHAT domain; Region: CHAT; cl17868
111780013696	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
111780013697	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
111780013698	AzlC protein; Region: AzlC; cl00570
111780013699	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
111780013700	putative active site [active]
111780013701	Ycf46; Provisional; Region: ycf46; CHL00195
111780013702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
111780013703	SprT homologues; Region: SprT; cl01182
111780013704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780013705	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
111780013706	Probable transposase; Region: OrfB_IS605; pfam01385
111780013707	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
111780013708	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
111780013709	DNA binding residues [nucleotide binding]
111780013710	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
111780013711	catalytic residues [active]
111780013712	catalytic nucleophile [active]
111780013713	Fic family protein [Function unknown]; Region: COG3177
111780013714	Fic/DOC family; Region: Fic; pfam02661
111780013715	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
111780013716	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
111780013717	active site
111780013718	metal binding site [ion binding]; metal-binding site
111780013719	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
111780013720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013721	active site
111780013722	phosphorylation site [posttranslational modification]
111780013723	intermolecular recognition site; other site
111780013724	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
111780013725	DNA binding residues [nucleotide binding]
111780013726	dimerization interface [polypeptide binding]; other site
111780013727	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
111780013728	Mg binding site [ion binding]; other site
111780013729	nucleotide binding site [chemical binding]; other site
111780013730	putative protofilament interface [polypeptide binding]; other site
111780013731	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
111780013732	RES domain; Region: RES; pfam08808
111780013733	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
111780013734	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
111780013735	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
111780013736	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780013737	putative active site [active]
111780013738	Helix-turn-helix domain; Region: HTH_37; pfam13744
111780013739	non-specific DNA binding site [nucleotide binding]; other site
111780013740	salt bridge; other site
111780013741	sequence-specific DNA binding site [nucleotide binding]; other site
111780013742	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
111780013743	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
111780013744	active site
111780013745	catalytic residues [active]
111780013746	DNA binding site [nucleotide binding]
111780013747	Int/Topo IB signature motif; other site
111780013748	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780013749	Probable transposase; Region: OrfB_IS605; pfam01385
111780013750	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
111780013751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780013752	non-specific DNA binding site [nucleotide binding]; other site
111780013753	salt bridge; other site
111780013754	sequence-specific DNA binding site [nucleotide binding]; other site
111780013755	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
111780013756	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
111780013757	Zn binding site [ion binding]; other site
111780013758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780013759	Walker A motif; other site
111780013760	ATP binding site [chemical binding]; other site
111780013761	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
111780013762	active site
111780013763	metal binding site [ion binding]; metal-binding site
111780013764	interdomain interaction site; other site
111780013765	AAA domain; Region: AAA_30; pfam13604
111780013766	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
111780013767	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780013768	non-specific DNA binding site [nucleotide binding]; other site
111780013769	salt bridge; other site
111780013770	sequence-specific DNA binding site [nucleotide binding]; other site
111780013771	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
111780013772	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
111780013773	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
111780013774	putative active site [active]
111780013775	metal binding site [ion binding]; metal-binding site
111780013776	PAS domain; Region: PAS_9; pfam13426
111780013777	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780013778	putative active site [active]
111780013779	heme pocket [chemical binding]; other site
111780013780	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
111780013781	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
111780013782	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
111780013783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
111780013784	putative active site [active]
111780013785	heme pocket [chemical binding]; other site
111780013786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780013787	dimer interface [polypeptide binding]; other site
111780013788	phosphorylation site [posttranslational modification]
111780013789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780013790	ATP binding site [chemical binding]; other site
111780013791	Mg2+ binding site [ion binding]; other site
111780013792	G-X-G motif; other site
111780013793	Response regulator receiver domain; Region: Response_reg; pfam00072
111780013794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013795	active site
111780013796	phosphorylation site [posttranslational modification]
111780013797	intermolecular recognition site; other site
111780013798	dimerization interface [polypeptide binding]; other site
111780013799	phosphoenolpyruvate synthase; Validated; Region: PRK06464
111780013800	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
111780013801	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
111780013802	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
111780013803	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
111780013804	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
111780013805	NAD binding site [chemical binding]; other site
111780013806	dimer interface [polypeptide binding]; other site
111780013807	substrate binding site [chemical binding]; other site
111780013808	tetramer (dimer of dimers) interface [polypeptide binding]; other site
111780013809	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
111780013810	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
111780013811	putative active site [active]
111780013812	putative FMN binding site [chemical binding]; other site
111780013813	putative substrate binding site [chemical binding]; other site
111780013814	Response regulator receiver domain; Region: Response_reg; pfam00072
111780013815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013816	active site
111780013817	phosphorylation site [posttranslational modification]
111780013818	dimerization interface [polypeptide binding]; other site
111780013819	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780013820	active site
111780013821	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780013822	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
111780013823	active site
111780013824	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
111780013825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780013826	Walker A motif; other site
111780013827	ATP binding site [chemical binding]; other site
111780013828	Walker B motif; other site
111780013829	arginine finger; other site
111780013830	Peptidase family M41; Region: Peptidase_M41; pfam01434
111780013831	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
111780013832	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
111780013833	Cytochrome P450; Region: p450; cl12078
111780013834	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
111780013835	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
111780013836	Domain of unknown function (DUF305); Region: DUF305; cl17794
111780013837	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
111780013838	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
111780013839	putative dimer interface [polypeptide binding]; other site
111780013840	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780013841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013842	active site
111780013843	phosphorylation site [posttranslational modification]
111780013844	intermolecular recognition site; other site
111780013845	dimerization interface [polypeptide binding]; other site
111780013846	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780013847	DNA binding site [nucleotide binding]
111780013848	Hpt domain; Region: Hpt; pfam01627
111780013849	putative binding surface; other site
111780013850	active site
111780013851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013852	active site
111780013853	phosphorylation site [posttranslational modification]
111780013854	intermolecular recognition site; other site
111780013855	Response regulator receiver domain; Region: Response_reg; pfam00072
111780013856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780013857	active site
111780013858	phosphorylation site [posttranslational modification]
111780013859	intermolecular recognition site; other site
111780013860	dimerization interface [polypeptide binding]; other site
111780013861	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
111780013862	putative active site [active]
111780013863	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780013864	Ligand Binding Site [chemical binding]; other site
111780013865	Rubrerythrin [Energy production and conversion]; Region: COG1592
111780013866	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
111780013867	iron binding site [ion binding]; other site
111780013868	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
111780013869	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
111780013870	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
111780013871	dimerization interface [polypeptide binding]; other site
111780013872	DPS ferroxidase diiron center [ion binding]; other site
111780013873	ion pore; other site
111780013874	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780013875	Ligand Binding Site [chemical binding]; other site
111780013876	YwiC-like protein; Region: YwiC; pfam14256
111780013877	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
111780013878	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
111780013879	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
111780013880	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
111780013881	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
111780013882	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
111780013883	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
111780013884	iron-sulfur cluster [ion binding]; other site
111780013885	[2Fe-2S] cluster binding site [ion binding]; other site
111780013886	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
111780013887	pheophytin binding site; other site
111780013888	chlorophyll binding site; other site
111780013889	quinone binding site; other site
111780013890	Fe binding site [ion binding]; other site
111780013891	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
111780013892	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
111780013893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780013894	S-adenosylmethionine binding site [chemical binding]; other site
111780013895	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
111780013896	L-lactate permease; Region: Lactate_perm; cl00701
111780013897	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
111780013898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
111780013899	MOSC domain; Region: MOSC; pfam03473
111780013900	3-alpha domain; Region: 3-alpha; pfam03475
111780013901	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
111780013902	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
111780013903	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780013904	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780013905	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
111780013906	Soluble P-type ATPase [General function prediction only]; Region: COG4087
111780013907	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
111780013908	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
111780013909	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
111780013910	ligand binding site [chemical binding]; other site
111780013911	flexible hinge region; other site
111780013912	HPP family; Region: HPP; pfam04982
111780013913	Methyltransferase domain; Region: Methyltransf_31; pfam13847
111780013914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780013915	S-adenosylmethionine binding site [chemical binding]; other site
111780013916	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
111780013917	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
111780013918	heme-binding site [chemical binding]; other site
111780013919	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
111780013920	nucleoside/Zn binding site; other site
111780013921	dimer interface [polypeptide binding]; other site
111780013922	catalytic motif [active]
111780013923	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
111780013924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780013925	NAD(P) binding site [chemical binding]; other site
111780013926	active site
111780013927	Homeodomain-like domain; Region: HTH_23; pfam13384
111780013928	Winged helix-turn helix; Region: HTH_29; pfam13551
111780013929	Homeodomain-like domain; Region: HTH_32; pfam13565
111780013930	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
111780013931	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780013932	NAD(P) binding site [chemical binding]; other site
111780013933	active site
111780013934	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
111780013935	active site
111780013936	homotetramer interface [polypeptide binding]; other site
111780013937	META domain; Region: META; pfam03724
111780013938	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
111780013939	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
111780013940	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
111780013941	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
111780013942	active site
111780013943	substrate binding site [chemical binding]; other site
111780013944	Mg2+ binding site [ion binding]; other site
111780013945	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013946	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013947	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013948	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013949	FOG: PKD repeat [General function prediction only]; Region: COG3291
111780013950	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013951	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013952	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
111780013953	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013954	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013955	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013956	FOG: PKD repeat [General function prediction only]; Region: COG3291
111780013957	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013958	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013959	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
111780013960	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
111780013961	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780013962	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780013963	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780013964	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
111780013965	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
111780013966	AAA domain; Region: AAA_17; pfam13207
111780013967	AAA domain; Region: AAA_33; pfam13671
111780013968	WYL domain; Region: WYL; pfam13280
111780013969	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
111780013970	DDE superfamily endonuclease; Region: DDE_3; pfam13358
111780013971	Winged helix-turn helix; Region: HTH_29; pfam13551
111780013972	Homeodomain-like domain; Region: HTH_23; pfam13384
111780013973	Caspase domain; Region: Peptidase_C14; pfam00656
111780013974	AAA ATPase domain; Region: AAA_16; pfam13191
111780013975	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013976	WD domain, G-beta repeat; Region: WD40; pfam00400
111780013977	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013978	structural tetrad; other site
111780013979	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
111780013980	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013981	structural tetrad; other site
111780013982	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
111780013983	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
111780013984	FOG: WD40 repeat [General function prediction only]; Region: COG2319
111780013985	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
111780013986	DDE superfamily endonuclease; Region: DDE_3; pfam13358
111780013987	Winged helix-turn helix; Region: HTH_29; pfam13551
111780013988	Homeodomain-like domain; Region: HTH_23; pfam13384
111780013989	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
111780013990	aromatic arch; other site
111780013991	DCoH dimer interaction site [polypeptide binding]; other site
111780013992	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
111780013993	DCoH tetramer interaction site [polypeptide binding]; other site
111780013994	substrate binding site [chemical binding]; other site
111780013995	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
111780013996	ParB-like nuclease domain; Region: ParBc; pfam02195
111780013997	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
111780013998	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
111780013999	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
111780014000	P-loop; other site
111780014001	Magnesium ion binding site [ion binding]; other site
111780014002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
111780014003	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
111780014004	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
111780014005	active site
111780014006	DNA binding site [nucleotide binding]
111780014007	Int/Topo IB signature motif; other site
111780014008	YEATS family; Region: YEATS; pfam03366
111780014009	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
111780014010	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
111780014011	Transposase [DNA replication, recombination, and repair]; Region: COG5433
111780014012	Transposase [DNA replication, recombination, and repair]; Region: COG5433
111780014013	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
111780014014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780014015	non-specific DNA binding site [nucleotide binding]; other site
111780014016	salt bridge; other site
111780014017	sequence-specific DNA binding site [nucleotide binding]; other site
111780014018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
111780014019	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
111780014020	Zn binding site [ion binding]; other site
111780014021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
111780014022	Walker A motif; other site
111780014023	ATP binding site [chemical binding]; other site
111780014024	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
111780014025	active site
111780014026	metal binding site [ion binding]; metal-binding site
111780014027	interdomain interaction site; other site
111780014028	AAA domain; Region: AAA_30; pfam13604
111780014029	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
111780014030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
111780014031	non-specific DNA binding site [nucleotide binding]; other site
111780014032	salt bridge; other site
111780014033	sequence-specific DNA binding site [nucleotide binding]; other site
111780014034	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
111780014035	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780014036	Multicopper oxidase; Region: Cu-oxidase; pfam00394
111780014037	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780014038	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
111780014039	S-layer homology domain; Region: SLH; pfam00395
111780014040	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
111780014041	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
111780014042	metal-binding site [ion binding]
111780014043	Uncharacterized conserved protein [Function unknown]; Region: COG3350
111780014044	Uncharacterized conserved protein [Function unknown]; Region: COG3350
111780014045	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
111780014046	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780014047	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
111780014048	motif II; other site
111780014049	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
111780014050	Ligand Binding Site [chemical binding]; other site
111780014051	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
111780014052	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
111780014053	Multicopper oxidase; Region: Cu-oxidase; pfam00394
111780014054	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
111780014055	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
111780014056	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
111780014057	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
111780014058	Uncharacterized conserved protein [Function unknown]; Region: COG0398
111780014059	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
111780014060	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
111780014061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
111780014062	S-adenosylmethionine binding site [chemical binding]; other site
111780014063	YHS domain; Region: YHS; pfam04945
111780014064	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
111780014065	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
111780014066	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
111780014067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
111780014068	NAD(P) binding site [chemical binding]; other site
111780014069	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
111780014070	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
111780014071	DNA binding residues [nucleotide binding]
111780014072	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
111780014073	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780014074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780014075	active site
111780014076	phosphorylation site [posttranslational modification]
111780014077	intermolecular recognition site; other site
111780014078	dimerization interface [polypeptide binding]; other site
111780014079	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780014080	DNA binding site [nucleotide binding]
111780014081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780014082	dimer interface [polypeptide binding]; other site
111780014083	phosphorylation site [posttranslational modification]
111780014084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780014085	ATP binding site [chemical binding]; other site
111780014086	Mg2+ binding site [ion binding]; other site
111780014087	G-X-G motif; other site
111780014088	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
111780014089	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780014090	Soluble P-type ATPase [General function prediction only]; Region: COG4087
111780014091	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
111780014092	dimerization interface [polypeptide binding]; other site
111780014093	Domain of unknown function (DUF305); Region: DUF305; cl17794
111780014094	Ion channel; Region: Ion_trans_2; pfam07885
111780014095	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
111780014096	metal-binding site [ion binding]
111780014097	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
111780014098	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
111780014099	metal-binding site [ion binding]
111780014100	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
111780014101	Soluble P-type ATPase [General function prediction only]; Region: COG4087
111780014102	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
111780014103	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
111780014104	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
111780014105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
111780014106	dimer interface [polypeptide binding]; other site
111780014107	phosphorylation site [posttranslational modification]
111780014108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
111780014109	ATP binding site [chemical binding]; other site
111780014110	Mg2+ binding site [ion binding]; other site
111780014111	G-X-G motif; other site
111780014112	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
111780014113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
111780014114	active site
111780014115	phosphorylation site [posttranslational modification]
111780014116	intermolecular recognition site; other site
111780014117	dimerization interface [polypeptide binding]; other site
111780014118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
111780014119	DNA binding site [nucleotide binding]
111780014120	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
111780014121	Probable transposase; Region: OrfB_IS605; pfam01385
111780014122	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
111780014123	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
111780014124	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
111780014125	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
111780014126	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
111780014127	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
111780014128	active site
111780014129	metal-binding site