-- dump date 20140620_073051 -- class Genbank::misc_feature -- table misc_feature_note -- id note 703339000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 703339000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 703339000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339000004 Walker A motif; other site 703339000005 ATP binding site [chemical binding]; other site 703339000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 703339000007 Walker B motif; other site 703339000008 arginine finger; other site 703339000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 703339000010 DnaA box-binding interface [nucleotide binding]; other site 703339000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 703339000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 703339000013 putative DNA binding surface [nucleotide binding]; other site 703339000014 dimer interface [polypeptide binding]; other site 703339000015 beta-clamp/clamp loader binding surface; other site 703339000016 beta-clamp/translesion DNA polymerase binding surface; other site 703339000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 703339000018 recF protein; Region: recf; TIGR00611 703339000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 703339000020 Walker A/P-loop; other site 703339000021 ATP binding site [chemical binding]; other site 703339000022 Q-loop/lid; other site 703339000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339000024 ABC transporter signature motif; other site 703339000025 Walker B; other site 703339000026 D-loop; other site 703339000027 H-loop/switch region; other site 703339000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 703339000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339000030 Mg2+ binding site [ion binding]; other site 703339000031 G-X-G motif; other site 703339000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 703339000033 anchoring element; other site 703339000034 dimer interface [polypeptide binding]; other site 703339000035 ATP binding site [chemical binding]; other site 703339000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 703339000037 active site 703339000038 putative metal-binding site [ion binding]; other site 703339000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 703339000040 DNA gyrase subunit A; Validated; Region: PRK05560 703339000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 703339000042 CAP-like domain; other site 703339000043 active site 703339000044 primary dimer interface [polypeptide binding]; other site 703339000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 703339000052 putative substrate binding site [chemical binding]; other site 703339000053 putative ATP binding site [chemical binding]; other site 703339000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 703339000055 active sites [active] 703339000056 tetramer interface [polypeptide binding]; other site 703339000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 703339000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 703339000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 703339000060 dimer interface [polypeptide binding]; other site 703339000061 active site 703339000062 motif 1; other site 703339000063 motif 2; other site 703339000064 motif 3; other site 703339000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 703339000066 Predicted membrane protein [Function unknown]; Region: COG4392 703339000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 703339000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 703339000069 Predicted membrane protein [Function unknown]; Region: COG4241 703339000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 703339000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 703339000072 DHH family; Region: DHH; pfam01368 703339000073 DHHA1 domain; Region: DHHA1; pfam02272 703339000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 703339000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 703339000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 703339000077 replicative DNA helicase; Region: DnaB; TIGR00665 703339000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 703339000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 703339000080 Walker A motif; other site 703339000081 ATP binding site [chemical binding]; other site 703339000082 Walker B motif; other site 703339000083 DNA binding loops [nucleotide binding] 703339000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 703339000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 703339000086 GDP-binding site [chemical binding]; other site 703339000087 ACT binding site; other site 703339000088 IMP binding site; other site 703339000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339000091 active site 703339000092 phosphorylation site [posttranslational modification] 703339000093 intermolecular recognition site; other site 703339000094 dimerization interface [polypeptide binding]; other site 703339000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339000096 DNA binding site [nucleotide binding] 703339000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 703339000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 703339000099 dimerization interface [polypeptide binding]; other site 703339000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 703339000101 putative active site [active] 703339000102 heme pocket [chemical binding]; other site 703339000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339000104 dimer interface [polypeptide binding]; other site 703339000105 phosphorylation site [posttranslational modification] 703339000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339000107 ATP binding site [chemical binding]; other site 703339000108 Mg2+ binding site [ion binding]; other site 703339000109 G-X-G motif; other site 703339000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 703339000111 YycH protein; Region: YycH; pfam07435 703339000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 703339000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 703339000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 703339000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 703339000116 putative active site [active] 703339000117 putative metal binding site [ion binding]; other site 703339000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 703339000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 703339000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 703339000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 703339000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 703339000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 703339000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 703339000125 Integrase core domain; Region: rve; pfam00665 703339000126 Replication protein; Region: Rep_1; cl02412 703339000127 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 703339000128 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 703339000129 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 703339000130 dimer interface [polypeptide binding]; other site 703339000131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 703339000132 ligand binding site [chemical binding]; other site 703339000133 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 703339000134 metal binding triad [ion binding]; metal-binding site 703339000135 KNTase C-terminal domain; Region: KNTase_C; pfam07827 703339000136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 703339000137 Integrase core domain; Region: rve; pfam00665 703339000138 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 703339000139 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 703339000140 putative active site [active] 703339000141 catalytic site [active] 703339000142 putative metal binding site [ion binding]; other site 703339000143 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 703339000144 putative active site [active] 703339000145 putative catalytic site [active] 703339000146 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 703339000147 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 703339000148 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 703339000149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 703339000150 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 703339000151 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 703339000152 Predicted transcriptional regulator [Transcription]; Region: COG3682 703339000153 MarR family; Region: MarR_2; pfam12802 703339000154 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339000155 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 703339000156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 703339000157 nucleotide binding site [chemical binding]; other site 703339000158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 703339000159 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 703339000160 active site residue [active] 703339000161 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 703339000162 CPxP motif; other site 703339000163 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 703339000164 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 703339000165 putative homodimer interface [polypeptide binding]; other site 703339000166 putative homotetramer interface [polypeptide binding]; other site 703339000167 putative metal binding site [ion binding]; other site 703339000168 putative homodimer-homodimer interface [polypeptide binding]; other site 703339000169 putative allosteric switch controlling residues; other site 703339000170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339000171 S-adenosylmethionine binding site [chemical binding]; other site 703339000172 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 703339000173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339000174 S-adenosylmethionine binding site [chemical binding]; other site 703339000175 aminoglycoside resistance protein; Provisional; Region: PRK13746 703339000176 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 703339000177 active site 703339000178 NTP binding site [chemical binding]; other site 703339000179 metal binding triad [ion binding]; metal-binding site 703339000180 antibiotic binding site [chemical binding]; other site 703339000181 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 703339000182 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 703339000183 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 703339000184 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 703339000185 Int/Topo IB signature motif; other site 703339000186 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 703339000187 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 703339000188 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 703339000189 Int/Topo IB signature motif; other site 703339000190 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 703339000191 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 703339000192 MPN+ (JAMM) motif; other site 703339000193 Zinc-binding site [ion binding]; other site 703339000194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 703339000195 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 703339000196 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 703339000197 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 703339000198 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 703339000199 catalytic residues [active] 703339000200 catalytic nucleophile [active] 703339000201 Presynaptic Site I dimer interface [polypeptide binding]; other site 703339000202 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 703339000203 Synaptic Flat tetramer interface [polypeptide binding]; other site 703339000204 Synaptic Site I dimer interface [polypeptide binding]; other site 703339000205 DNA binding site [nucleotide binding] 703339000206 Recombinase; Region: Recombinase; pfam07508 703339000207 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 703339000208 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 703339000209 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 703339000210 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 703339000211 catalytic residues [active] 703339000212 catalytic nucleophile [active] 703339000213 Recombinase; Region: Recombinase; pfam07508 703339000214 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 703339000215 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 703339000216 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 703339000217 Integrase core domain; Region: rve; pfam00665 703339000218 Integrase core domain; Region: rve_3; cl15866 703339000219 HTH-like domain; Region: HTH_21; pfam13276 703339000220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 703339000221 Homeodomain-like domain; Region: HTH_23; cl17451 703339000222 Predicted membrane protein [Function unknown]; Region: COG1288 703339000223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339000225 active site 703339000226 phosphorylation site [posttranslational modification] 703339000227 intermolecular recognition site; other site 703339000228 dimerization interface [polypeptide binding]; other site 703339000229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339000230 DNA binding site [nucleotide binding] 703339000231 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 703339000232 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 703339000233 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 703339000234 Ligand Binding Site [chemical binding]; other site 703339000235 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 703339000236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339000237 dimer interface [polypeptide binding]; other site 703339000238 phosphorylation site [posttranslational modification] 703339000239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339000240 ATP binding site [chemical binding]; other site 703339000241 Mg2+ binding site [ion binding]; other site 703339000242 G-X-G motif; other site 703339000243 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 703339000244 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 703339000245 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 703339000246 Soluble P-type ATPase [General function prediction only]; Region: COG4087 703339000247 K+-transporting ATPase, c chain; Region: KdpC; cl00944 703339000248 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 703339000249 Protein kinase domain; Region: Pkinase; pfam00069 703339000250 Catalytic domain of Protein Kinases; Region: PKc; cd00180 703339000251 active site 703339000252 ATP binding site [chemical binding]; other site 703339000253 substrate binding site [chemical binding]; other site 703339000254 activation loop (A-loop); other site 703339000255 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 703339000256 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 703339000257 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 703339000258 phosphate binding site [ion binding]; other site 703339000259 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 703339000260 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 703339000261 putative homodimer interface [polypeptide binding]; other site 703339000262 putative homotetramer interface [polypeptide binding]; other site 703339000263 putative metal binding site [ion binding]; other site 703339000264 putative homodimer-homodimer interface [polypeptide binding]; other site 703339000265 putative allosteric switch controlling residues; other site 703339000266 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 703339000267 active site residue [active] 703339000268 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 703339000269 CPxP motif; other site 703339000270 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 703339000271 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 703339000272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 703339000273 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 703339000274 active site residue [active] 703339000275 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 703339000276 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 703339000277 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 703339000278 FMN binding site [chemical binding]; other site 703339000279 active site 703339000280 catalytic residues [active] 703339000281 substrate binding site [chemical binding]; other site 703339000282 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 703339000283 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 703339000284 Part of AAA domain; Region: AAA_19; pfam13245 703339000285 AAA domain; Region: AAA_12; pfam13087 703339000286 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 703339000287 active site 703339000288 catalytic site [active] 703339000289 putative metal binding site [ion binding]; other site 703339000290 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339000291 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339000292 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339000293 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339000294 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339000295 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 703339000296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 703339000297 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 703339000298 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 703339000299 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 703339000300 metal binding site [ion binding]; metal-binding site 703339000301 dimer interface [polypeptide binding]; other site 703339000302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339000303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339000304 putative substrate translocation pore; other site 703339000305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339000306 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 703339000307 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 703339000308 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 703339000309 PhoU domain; Region: PhoU; pfam01895 703339000310 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 703339000311 EamA-like transporter family; Region: EamA; pfam00892 703339000312 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 703339000313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339000314 DNA-binding site [nucleotide binding]; DNA binding site 703339000315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339000316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339000317 homodimer interface [polypeptide binding]; other site 703339000318 catalytic residue [active] 703339000319 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 703339000320 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 703339000321 L-lactate permease; Region: Lactate_perm; cl00701 703339000322 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339000323 B domain; Region: B; pfam02216 703339000324 B domain; Region: B; pfam02216 703339000325 B domain; Region: B; pfam02216 703339000326 B domain; Region: B; pfam02216 703339000327 B domain; Region: B; pfam02216 703339000328 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339000329 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339000330 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339000331 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339000332 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339000333 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 703339000334 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339000335 ABC-ATPase subunit interface; other site 703339000336 dimer interface [polypeptide binding]; other site 703339000337 putative PBP binding regions; other site 703339000338 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 703339000339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339000340 ABC-ATPase subunit interface; other site 703339000341 dimer interface [polypeptide binding]; other site 703339000342 putative PBP binding regions; other site 703339000343 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 703339000344 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 703339000345 siderophore binding site; other site 703339000346 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 703339000347 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 703339000348 dimer interface [polypeptide binding]; other site 703339000349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339000350 catalytic residue [active] 703339000351 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 703339000352 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 703339000353 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 703339000354 IucA / IucC family; Region: IucA_IucC; pfam04183 703339000355 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 703339000356 drug efflux system protein MdtG; Provisional; Region: PRK09874 703339000357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339000358 putative substrate translocation pore; other site 703339000359 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 703339000360 IucA / IucC family; Region: IucA_IucC; pfam04183 703339000361 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 703339000362 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 703339000363 IucA / IucC family; Region: IucA_IucC; pfam04183 703339000364 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 703339000365 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 703339000366 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 703339000367 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 703339000368 dimer interface [polypeptide binding]; other site 703339000369 active site 703339000370 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 703339000371 catalytic residues [active] 703339000372 substrate binding site [chemical binding]; other site 703339000373 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 703339000374 ParB-like nuclease domain; Region: ParBc; pfam02195 703339000375 acetoin reductase; Validated; Region: PRK08643 703339000376 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 703339000377 NAD binding site [chemical binding]; other site 703339000378 homotetramer interface [polypeptide binding]; other site 703339000379 homodimer interface [polypeptide binding]; other site 703339000380 active site 703339000381 substrate binding site [chemical binding]; other site 703339000382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339000383 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 703339000384 NAD(P) binding site [chemical binding]; other site 703339000385 active site 703339000386 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 703339000387 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 703339000388 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 703339000389 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 703339000390 putative ADP-binding pocket [chemical binding]; other site 703339000391 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 703339000392 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 703339000393 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 703339000394 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 703339000395 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 703339000396 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 703339000397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339000398 DNA-binding site [nucleotide binding]; DNA binding site 703339000399 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 703339000400 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 703339000401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339000402 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 703339000403 intersubunit interface [polypeptide binding]; other site 703339000404 active site 703339000405 catalytic residue [active] 703339000406 phosphopentomutase; Provisional; Region: PRK05362 703339000407 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 703339000408 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 703339000409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339000410 dimer interface [polypeptide binding]; other site 703339000411 conserved gate region; other site 703339000412 putative PBP binding loops; other site 703339000413 ABC-ATPase subunit interface; other site 703339000414 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 703339000415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339000416 dimer interface [polypeptide binding]; other site 703339000417 conserved gate region; other site 703339000418 ABC-ATPase subunit interface; other site 703339000419 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 703339000420 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 703339000421 Walker A/P-loop; other site 703339000422 ATP binding site [chemical binding]; other site 703339000423 Q-loop/lid; other site 703339000424 ABC transporter signature motif; other site 703339000425 Walker B; other site 703339000426 D-loop; other site 703339000427 H-loop/switch region; other site 703339000428 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 703339000429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 703339000430 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 703339000431 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 703339000432 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 703339000433 active site 703339000434 metal binding site [ion binding]; metal-binding site 703339000435 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 703339000436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 703339000437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339000438 non-specific DNA binding site [nucleotide binding]; other site 703339000439 salt bridge; other site 703339000440 sequence-specific DNA binding site [nucleotide binding]; other site 703339000441 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 703339000442 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 703339000443 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 703339000444 putative catalytic cysteine [active] 703339000445 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 703339000446 putative active site [active] 703339000447 metal binding site [ion binding]; metal-binding site 703339000448 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 703339000449 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 703339000450 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 703339000451 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 703339000452 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 703339000453 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 703339000454 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 703339000455 NAD(P) binding site [chemical binding]; other site 703339000456 homodimer interface [polypeptide binding]; other site 703339000457 substrate binding site [chemical binding]; other site 703339000458 active site 703339000459 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 703339000460 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 703339000461 NAD(P) binding site [chemical binding]; other site 703339000462 homodimer interface [polypeptide binding]; other site 703339000463 substrate binding site [chemical binding]; other site 703339000464 active site 703339000465 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 703339000466 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 703339000467 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 703339000468 putative NAD(P) binding site [chemical binding]; other site 703339000469 active site 703339000470 putative substrate binding site [chemical binding]; other site 703339000471 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 703339000472 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 703339000473 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 703339000474 active site 703339000475 homodimer interface [polypeptide binding]; other site 703339000476 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 703339000477 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 703339000478 trimer interface [polypeptide binding]; other site 703339000479 active site 703339000480 substrate binding site [chemical binding]; other site 703339000481 CoA binding site [chemical binding]; other site 703339000482 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 703339000483 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 703339000484 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 703339000485 O-Antigen ligase; Region: Wzy_C; pfam04932 703339000486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 703339000487 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 703339000488 Bacterial sugar transferase; Region: Bac_transf; pfam02397 703339000489 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 703339000490 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 703339000491 putative NAD(P) binding site [chemical binding]; other site 703339000492 active site 703339000493 putative substrate binding site [chemical binding]; other site 703339000494 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 703339000495 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 703339000496 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 703339000497 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 703339000498 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 703339000499 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 703339000500 active site 703339000501 homodimer interface [polypeptide binding]; other site 703339000502 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 703339000503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 703339000504 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 703339000505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 703339000506 NAD(P) binding site [chemical binding]; other site 703339000507 catalytic residues [active] 703339000508 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 703339000509 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 703339000510 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339000511 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 703339000512 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 703339000513 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 703339000514 Walker A/P-loop; other site 703339000515 ATP binding site [chemical binding]; other site 703339000516 Q-loop/lid; other site 703339000517 ABC transporter signature motif; other site 703339000518 Walker B; other site 703339000519 D-loop; other site 703339000520 H-loop/switch region; other site 703339000521 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 703339000522 NMT1-like family; Region: NMT1_2; pfam13379 703339000523 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 703339000524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 703339000525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 703339000526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 703339000527 active site 703339000528 Uncharacterized conserved protein [Function unknown]; Region: COG5609 703339000529 formate dehydrogenase; Provisional; Region: PRK07574 703339000530 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 703339000531 dimerization interface [polypeptide binding]; other site 703339000532 ligand binding site [chemical binding]; other site 703339000533 NAD binding site [chemical binding]; other site 703339000534 catalytic site [active] 703339000535 putative transporter; Provisional; Region: PRK10054 703339000536 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 703339000537 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 703339000538 acyl-activating enzyme (AAE) consensus motif; other site 703339000539 AMP binding site [chemical binding]; other site 703339000540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 703339000541 Condensation domain; Region: Condensation; pfam00668 703339000542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 703339000543 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 703339000544 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 703339000545 acyl-activating enzyme (AAE) consensus motif; other site 703339000546 AMP binding site [chemical binding]; other site 703339000547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 703339000548 thioester reductase domain; Region: Thioester-redct; TIGR01746 703339000549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339000550 NAD(P) binding site [chemical binding]; other site 703339000551 active site 703339000552 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 703339000553 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 703339000554 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 703339000555 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 703339000556 nucleotide binding site [chemical binding]; other site 703339000557 N-acetyl-L-glutamate binding site [chemical binding]; other site 703339000558 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 703339000559 heterotetramer interface [polypeptide binding]; other site 703339000560 active site pocket [active] 703339000561 cleavage site 703339000562 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 703339000563 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 703339000564 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 703339000565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 703339000566 inhibitor-cofactor binding pocket; inhibition site 703339000567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339000568 catalytic residue [active] 703339000569 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 703339000570 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 703339000571 Isochorismatase family; Region: Isochorismatase; pfam00857 703339000572 catalytic triad [active] 703339000573 conserved cis-peptide bond; other site 703339000574 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 703339000575 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 703339000576 dimer interface [polypeptide binding]; other site 703339000577 PYR/PP interface [polypeptide binding]; other site 703339000578 TPP binding site [chemical binding]; other site 703339000579 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 703339000580 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 703339000581 TPP-binding site [chemical binding]; other site 703339000582 dimer interface [polypeptide binding]; other site 703339000583 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339000584 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 703339000585 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339000586 active site turn [active] 703339000587 phosphorylation site [posttranslational modification] 703339000588 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 703339000589 HPr interaction site; other site 703339000590 glycerol kinase (GK) interaction site [polypeptide binding]; other site 703339000591 active site 703339000592 phosphorylation site [posttranslational modification] 703339000593 Uncharacterized conserved protein [Function unknown]; Region: COG3589 703339000594 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 703339000595 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 703339000596 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 703339000597 putative active site [active] 703339000598 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 703339000599 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339000600 active site turn [active] 703339000601 phosphorylation site [posttranslational modification] 703339000602 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339000603 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 703339000604 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 703339000605 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 703339000606 putative active site [active] 703339000607 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 703339000608 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 703339000609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339000610 ATP binding site [chemical binding]; other site 703339000611 putative Mg++ binding site [ion binding]; other site 703339000612 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 703339000613 HlyD family secretion protein; Region: HlyD_3; pfam13437 703339000614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 703339000615 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339000616 Walker A/P-loop; other site 703339000617 ATP binding site [chemical binding]; other site 703339000618 Q-loop/lid; other site 703339000619 ABC transporter signature motif; other site 703339000620 Walker B; other site 703339000621 D-loop; other site 703339000622 H-loop/switch region; other site 703339000623 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 703339000624 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 703339000625 FtsX-like permease family; Region: FtsX; pfam02687 703339000626 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 703339000627 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 703339000628 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339000629 Walker A/P-loop; other site 703339000630 ATP binding site [chemical binding]; other site 703339000631 Q-loop/lid; other site 703339000632 ABC transporter signature motif; other site 703339000633 Walker B; other site 703339000634 D-loop; other site 703339000635 H-loop/switch region; other site 703339000636 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 703339000637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339000638 Walker A/P-loop; other site 703339000639 ATP binding site [chemical binding]; other site 703339000640 Q-loop/lid; other site 703339000641 ABC transporter signature motif; other site 703339000642 Walker B; other site 703339000643 D-loop; other site 703339000644 H-loop/switch region; other site 703339000645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 703339000646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339000647 Walker A/P-loop; other site 703339000648 ATP binding site [chemical binding]; other site 703339000649 Q-loop/lid; other site 703339000650 ABC transporter signature motif; other site 703339000651 Walker B; other site 703339000652 D-loop; other site 703339000653 H-loop/switch region; other site 703339000654 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 703339000655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339000656 dimer interface [polypeptide binding]; other site 703339000657 conserved gate region; other site 703339000658 putative PBP binding loops; other site 703339000659 ABC-ATPase subunit interface; other site 703339000660 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 703339000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339000662 dimer interface [polypeptide binding]; other site 703339000663 conserved gate region; other site 703339000664 ABC-ATPase subunit interface; other site 703339000665 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 703339000666 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 703339000667 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 703339000668 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 703339000669 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 703339000670 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 703339000671 azoreductase; Reviewed; Region: PRK00170 703339000672 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 703339000673 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 703339000674 Peptidase family M23; Region: Peptidase_M23; pfam01551 703339000675 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 703339000676 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 703339000677 Walker A/P-loop; other site 703339000678 ATP binding site [chemical binding]; other site 703339000679 Q-loop/lid; other site 703339000680 ABC transporter signature motif; other site 703339000681 Walker B; other site 703339000682 D-loop; other site 703339000683 H-loop/switch region; other site 703339000684 TOBE domain; Region: TOBE; pfam03459 703339000685 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 703339000686 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 703339000687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339000688 dimer interface [polypeptide binding]; other site 703339000689 conserved gate region; other site 703339000690 ABC-ATPase subunit interface; other site 703339000691 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 703339000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339000693 dimer interface [polypeptide binding]; other site 703339000694 conserved gate region; other site 703339000695 putative PBP binding loops; other site 703339000696 ABC-ATPase subunit interface; other site 703339000697 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 703339000698 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 703339000699 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 703339000700 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 703339000701 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 703339000702 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 703339000703 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 703339000704 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 703339000705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 703339000706 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 703339000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339000708 putative substrate translocation pore; other site 703339000709 Response regulator receiver domain; Region: Response_reg; pfam00072 703339000710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339000711 active site 703339000712 phosphorylation site [posttranslational modification] 703339000713 intermolecular recognition site; other site 703339000714 dimerization interface [polypeptide binding]; other site 703339000715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 703339000716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 703339000717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 703339000718 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 703339000719 Histidine kinase; Region: His_kinase; pfam06580 703339000720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339000721 ATP binding site [chemical binding]; other site 703339000722 Mg2+ binding site [ion binding]; other site 703339000723 G-X-G motif; other site 703339000724 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 703339000725 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 703339000726 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 703339000727 Pyruvate formate lyase 1; Region: PFL1; cd01678 703339000728 coenzyme A binding site [chemical binding]; other site 703339000729 active site 703339000730 catalytic residues [active] 703339000731 glycine loop; other site 703339000732 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 703339000733 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339000734 FeS/SAM binding site; other site 703339000735 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 703339000736 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 703339000737 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 703339000738 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 703339000739 putative active site [active] 703339000740 catalytic site [active] 703339000741 putative metal binding site [ion binding]; other site 703339000742 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 703339000743 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 703339000744 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 703339000745 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 703339000746 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 703339000747 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 703339000748 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 703339000749 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 703339000750 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 703339000751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 703339000752 dimer interface [polypeptide binding]; other site 703339000753 active site 703339000754 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 703339000755 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 703339000756 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 703339000757 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 703339000758 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 703339000759 substrate binding site [chemical binding]; other site 703339000760 oxyanion hole (OAH) forming residues; other site 703339000761 trimer interface [polypeptide binding]; other site 703339000762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 703339000763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 703339000764 active site 703339000765 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 703339000766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 703339000767 acyl-activating enzyme (AAE) consensus motif; other site 703339000768 AMP binding site [chemical binding]; other site 703339000769 active site 703339000770 CoA binding site [chemical binding]; other site 703339000771 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 703339000772 Coenzyme A transferase; Region: CoA_trans; smart00882 703339000773 Coenzyme A transferase; Region: CoA_trans; cl17247 703339000774 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 703339000775 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 703339000776 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 703339000777 Uncharacterized conserved protein [Function unknown]; Region: COG3189 703339000778 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 703339000779 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 703339000780 heme-binding site [chemical binding]; other site 703339000781 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 703339000782 FAD binding pocket [chemical binding]; other site 703339000783 FAD binding motif [chemical binding]; other site 703339000784 phosphate binding motif [ion binding]; other site 703339000785 beta-alpha-beta structure motif; other site 703339000786 NAD binding pocket [chemical binding]; other site 703339000787 Heme binding pocket [chemical binding]; other site 703339000788 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 703339000789 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 703339000790 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339000791 NAD binding site [chemical binding]; other site 703339000792 dimer interface [polypeptide binding]; other site 703339000793 substrate binding site [chemical binding]; other site 703339000794 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 703339000795 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339000796 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339000797 active site turn [active] 703339000798 phosphorylation site [posttranslational modification] 703339000799 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 703339000800 active site 703339000801 tetramer interface [polypeptide binding]; other site 703339000802 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 703339000803 Mga helix-turn-helix domain; Region: Mga; pfam05043 703339000804 PRD domain; Region: PRD; pfam00874 703339000805 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 703339000806 active site 703339000807 P-loop; other site 703339000808 phosphorylation site [posttranslational modification] 703339000809 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339000810 active site 703339000811 phosphorylation site [posttranslational modification] 703339000812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339000813 active site 703339000814 phosphorylation site [posttranslational modification] 703339000815 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 703339000816 active site 703339000817 P-loop; other site 703339000818 phosphorylation site [posttranslational modification] 703339000819 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 703339000820 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 703339000821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 703339000822 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 703339000823 putative NAD(P) binding site [chemical binding]; other site 703339000824 catalytic Zn binding site [ion binding]; other site 703339000825 structural Zn binding site [ion binding]; other site 703339000826 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 703339000827 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 703339000828 putative NAD(P) binding site [chemical binding]; other site 703339000829 catalytic Zn binding site [ion binding]; other site 703339000830 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 703339000831 substrate binding site; other site 703339000832 dimer interface; other site 703339000833 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 703339000834 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 703339000835 putative NAD(P) binding site [chemical binding]; other site 703339000836 putative catalytic Zn binding site [ion binding]; other site 703339000837 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 703339000838 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 703339000839 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 703339000840 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 703339000841 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 703339000842 substrate binding site; other site 703339000843 dimer interface; other site 703339000844 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 703339000845 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 703339000846 putative NAD(P) binding site [chemical binding]; other site 703339000847 putative catalytic Zn binding site [ion binding]; other site 703339000848 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 703339000849 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 703339000850 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 703339000851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 703339000852 active site 703339000853 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 703339000854 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 703339000855 Hemerythrin-like domain; Region: Hr-like; cd12108 703339000856 Fe binding site [ion binding]; other site 703339000857 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 703339000858 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 703339000859 Histidine kinase; Region: His_kinase; pfam06580 703339000860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339000861 Mg2+ binding site [ion binding]; other site 703339000862 G-X-G motif; other site 703339000863 two-component response regulator; Provisional; Region: PRK14084 703339000864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339000865 active site 703339000866 phosphorylation site [posttranslational modification] 703339000867 intermolecular recognition site; other site 703339000868 dimerization interface [polypeptide binding]; other site 703339000869 LytTr DNA-binding domain; Region: LytTR; pfam04397 703339000870 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 703339000871 antiholin-like protein LrgB; Provisional; Region: PRK04288 703339000872 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 703339000873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339000874 DNA-binding site [nucleotide binding]; DNA binding site 703339000875 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 703339000876 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 703339000877 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 703339000878 HPr interaction site; other site 703339000879 glycerol kinase (GK) interaction site [polypeptide binding]; other site 703339000880 active site 703339000881 phosphorylation site [posttranslational modification] 703339000882 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 703339000883 beta-galactosidase; Region: BGL; TIGR03356 703339000884 Methyltransferase domain; Region: Methyltransf_31; pfam13847 703339000885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339000886 S-adenosylmethionine binding site [chemical binding]; other site 703339000887 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 703339000888 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 703339000889 substrate binding site [chemical binding]; other site 703339000890 dimer interface [polypeptide binding]; other site 703339000891 ATP binding site [chemical binding]; other site 703339000892 D-ribose pyranase; Provisional; Region: PRK11797 703339000893 Sugar transport protein; Region: Sugar_transport; pfam06800 703339000894 Transcriptional regulators [Transcription]; Region: PurR; COG1609 703339000895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 703339000896 DNA binding site [nucleotide binding] 703339000897 domain linker motif; other site 703339000898 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 703339000899 dimerization interface [polypeptide binding]; other site 703339000900 ligand binding site [chemical binding]; other site 703339000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339000902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339000903 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 703339000904 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 703339000905 active site 703339000906 Surface antigen [General function prediction only]; Region: COG3942 703339000907 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 703339000908 Peptidase family M23; Region: Peptidase_M23; pfam01551 703339000909 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339000910 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 703339000911 Walker A/P-loop; other site 703339000912 ATP binding site [chemical binding]; other site 703339000913 Q-loop/lid; other site 703339000914 ABC transporter signature motif; other site 703339000915 Walker B; other site 703339000916 D-loop; other site 703339000917 H-loop/switch region; other site 703339000918 Surface antigen [General function prediction only]; Region: COG3942 703339000919 CHAP domain; Region: CHAP; pfam05257 703339000920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 703339000921 Predicted membrane protein [Function unknown]; Region: COG1511 703339000922 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 703339000923 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 703339000924 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 703339000925 Uncharacterized small protein [Function unknown]; Region: COG5417 703339000926 Predicted membrane protein [Function unknown]; Region: COG4499 703339000927 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 703339000928 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 703339000929 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 703339000930 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 703339000931 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 703339000932 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 703339000933 Uncharacterized conserved protein [Function unknown]; Region: COG5444 703339000934 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 703339000935 Protein of unknown function, DUF600; Region: DUF600; cl04640 703339000936 Protein of unknown function, DUF600; Region: DUF600; cl04640 703339000937 Protein of unknown function, DUF600; Region: DUF600; cl04640 703339000938 Protein of unknown function, DUF600; Region: DUF600; cl04640 703339000939 Protein of unknown function, DUF600; Region: DUF600; cl04640 703339000940 Protein of unknown function, DUF600; Region: DUF600; cl04640 703339000941 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 703339000942 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 703339000943 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 703339000944 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 703339000945 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 703339000946 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 703339000947 FtsX-like permease family; Region: FtsX; pfam02687 703339000948 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 703339000949 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339000950 Walker A/P-loop; other site 703339000951 ATP binding site [chemical binding]; other site 703339000952 Q-loop/lid; other site 703339000953 ABC transporter signature motif; other site 703339000954 Walker B; other site 703339000955 D-loop; other site 703339000956 H-loop/switch region; other site 703339000957 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 703339000958 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 703339000959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339000960 non-specific DNA binding site [nucleotide binding]; other site 703339000961 salt bridge; other site 703339000962 sequence-specific DNA binding site [nucleotide binding]; other site 703339000963 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 703339000964 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 703339000965 substrate binding site [chemical binding]; other site 703339000966 ATP binding site [chemical binding]; other site 703339000967 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 703339000968 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 703339000969 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 703339000970 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 703339000971 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 703339000972 putative transporter; Provisional; Region: PRK10484 703339000973 Na binding site [ion binding]; other site 703339000974 N-acetylneuraminate lyase; Provisional; Region: PRK04147 703339000975 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 703339000976 inhibitor site; inhibition site 703339000977 active site 703339000978 dimer interface [polypeptide binding]; other site 703339000979 catalytic residue [active] 703339000980 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 703339000981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 703339000982 nucleotide binding site [chemical binding]; other site 703339000983 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 703339000984 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 703339000985 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 703339000986 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 703339000987 putative active site [active] 703339000988 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 703339000989 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 703339000990 putative active site cavity [active] 703339000991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 703339000992 Nucleoside recognition; Region: Gate; pfam07670 703339000993 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 703339000994 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 703339000995 PGAP1-like protein; Region: PGAP1; pfam07819 703339000996 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 703339000997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 703339000998 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 703339000999 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 703339001000 putative active site [active] 703339001001 putative FMN binding site [chemical binding]; other site 703339001002 putative substrate binding site [chemical binding]; other site 703339001003 putative catalytic residue [active] 703339001004 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 703339001005 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 703339001006 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 703339001007 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 703339001008 lipoyl attachment site [posttranslational modification]; other site 703339001009 Replication protein C N-terminal domain; Region: RP-C; pfam03428 703339001010 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 703339001011 putative ADP-ribose binding site [chemical binding]; other site 703339001012 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 703339001013 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 703339001014 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 703339001015 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 703339001016 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 703339001017 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 703339001018 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 703339001019 NADP binding site [chemical binding]; other site 703339001020 putative substrate binding site [chemical binding]; other site 703339001021 active site 703339001022 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 703339001023 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 703339001024 active site 703339001025 P-loop; other site 703339001026 phosphorylation site [posttranslational modification] 703339001027 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339001028 active site 703339001029 phosphorylation site [posttranslational modification] 703339001030 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 703339001031 HTH domain; Region: HTH_11; pfam08279 703339001032 HTH domain; Region: HTH_11; pfam08279 703339001033 PRD domain; Region: PRD; pfam00874 703339001034 PRD domain; Region: PRD; pfam00874 703339001035 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 703339001036 active site 703339001037 P-loop; other site 703339001038 phosphorylation site [posttranslational modification] 703339001039 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339001040 active site 703339001041 phosphorylation site [posttranslational modification] 703339001042 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339001043 MarR family; Region: MarR_2; pfam12802 703339001044 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 703339001045 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 703339001046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 703339001047 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 703339001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339001049 putative substrate translocation pore; other site 703339001050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339001051 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 703339001052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 703339001053 Zn binding site [ion binding]; other site 703339001054 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 703339001055 Zn binding site [ion binding]; other site 703339001056 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 703339001057 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 703339001058 Predicted flavoprotein [General function prediction only]; Region: COG0431 703339001059 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 703339001060 Predicted membrane protein [Function unknown]; Region: COG2855 703339001061 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 703339001062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339001063 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 703339001064 Imelysin; Region: Peptidase_M75; pfam09375 703339001065 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 703339001066 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 703339001067 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 703339001068 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 703339001069 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 703339001070 Phage envelope protein [General function prediction only]; Region: COG5562 703339001071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339001072 non-specific DNA binding site [nucleotide binding]; other site 703339001073 salt bridge; other site 703339001074 sequence-specific DNA binding site [nucleotide binding]; other site 703339001075 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 703339001076 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 703339001077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339001078 Walker A/P-loop; other site 703339001079 ATP binding site [chemical binding]; other site 703339001080 Q-loop/lid; other site 703339001081 ABC transporter signature motif; other site 703339001082 Walker B; other site 703339001083 D-loop; other site 703339001084 H-loop/switch region; other site 703339001085 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 703339001086 Predicted membrane protein [Function unknown]; Region: COG4292 703339001087 putative acyltransferase; Provisional; Region: PRK05790 703339001088 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 703339001089 dimer interface [polypeptide binding]; other site 703339001090 active site 703339001091 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 703339001092 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 703339001093 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 703339001094 THF binding site; other site 703339001095 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 703339001096 substrate binding site [chemical binding]; other site 703339001097 THF binding site; other site 703339001098 zinc-binding site [ion binding]; other site 703339001099 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 703339001100 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 703339001101 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 703339001102 FAD binding site [chemical binding]; other site 703339001103 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 703339001104 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 703339001105 homodimer interface [polypeptide binding]; other site 703339001106 substrate-cofactor binding pocket; other site 703339001107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339001108 catalytic residue [active] 703339001109 cystathionine gamma-synthase; Reviewed; Region: PRK08247 703339001110 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 703339001111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339001112 catalytic residue [active] 703339001113 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 703339001114 ParB-like nuclease domain; Region: ParB; smart00470 703339001115 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 703339001116 Mechanosensitive ion channel; Region: MS_channel; pfam00924 703339001117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 703339001118 GTP-binding protein YchF; Reviewed; Region: PRK09601 703339001119 YchF GTPase; Region: YchF; cd01900 703339001120 G1 box; other site 703339001121 GTP/Mg2+ binding site [chemical binding]; other site 703339001122 Switch I region; other site 703339001123 G2 box; other site 703339001124 Switch II region; other site 703339001125 G3 box; other site 703339001126 G4 box; other site 703339001127 G5 box; other site 703339001128 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 703339001129 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 703339001130 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 703339001131 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 703339001132 dimer interface [polypeptide binding]; other site 703339001133 ssDNA binding site [nucleotide binding]; other site 703339001134 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339001135 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 703339001136 Abi-like protein; Region: Abi_2; pfam07751 703339001137 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 703339001138 DNA binding site [nucleotide binding] 703339001139 active site 703339001140 Int/Topo IB signature motif; other site 703339001141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 703339001142 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 703339001144 Predicted membrane protein [Function unknown]; Region: COG3212 703339001145 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 703339001146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 703339001147 non-specific DNA binding site [nucleotide binding]; other site 703339001148 salt bridge; other site 703339001149 sequence-specific DNA binding site [nucleotide binding]; other site 703339001150 Predicted membrane protein [Function unknown]; Region: COG2261 703339001151 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 703339001152 catalytic core [active] 703339001153 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 703339001154 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 703339001155 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 703339001156 catalytic residue [active] 703339001157 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 703339001158 catalytic residues [active] 703339001159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 703339001160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339001161 peroxiredoxin; Region: AhpC; TIGR03137 703339001162 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 703339001163 dimer interface [polypeptide binding]; other site 703339001164 decamer (pentamer of dimers) interface [polypeptide binding]; other site 703339001165 catalytic triad [active] 703339001166 peroxidatic and resolving cysteines [active] 703339001167 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 703339001168 dimer interface [polypeptide binding]; other site 703339001169 FMN binding site [chemical binding]; other site 703339001170 NADPH bind site [chemical binding]; other site 703339001171 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 703339001172 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 703339001173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339001174 active site 703339001175 xanthine permease; Region: pbuX; TIGR03173 703339001176 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 703339001177 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 703339001178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 703339001179 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 703339001180 active site 703339001181 GMP synthase; Reviewed; Region: guaA; PRK00074 703339001182 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 703339001183 AMP/PPi binding site [chemical binding]; other site 703339001184 candidate oxyanion hole; other site 703339001185 catalytic triad [active] 703339001186 potential glutamine specificity residues [chemical binding]; other site 703339001187 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 703339001188 ATP Binding subdomain [chemical binding]; other site 703339001189 Ligand Binding sites [chemical binding]; other site 703339001190 Dimerization subdomain; other site 703339001191 Pathogenicity island SaPIn2 703339001192 PemK-like protein; Region: PemK; pfam02452 703339001193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 703339001194 Transposase; Region: HTH_Tnp_1; cl17663 703339001195 Predicted membrane protein [Function unknown]; Region: COG3759 703339001196 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 703339001197 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 703339001198 NADP binding site [chemical binding]; other site 703339001199 superantigen-like protein; Reviewed; Region: PRK13037 703339001200 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001201 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001202 superantigen-like protein; Reviewed; Region: PRK13041 703339001203 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001204 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001205 superantigen-like protein; Reviewed; Region: PRK13335 703339001206 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001207 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001208 superantigen-like protein; Reviewed; Region: PRK13042 703339001209 Mucin-like glycoprotein; Region: Mucin; pfam01456 703339001210 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001211 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001212 superantigen-like protein 5; Reviewed; Region: PRK13035 703339001213 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001214 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001215 superantigen-like protein 7; Reviewed; Region: PRK13346 703339001216 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001217 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001218 superantigen-like protein; Reviewed; Region: PRK13039 703339001219 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001220 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001221 superantigen-like protein; Reviewed; Region: PRK13345 703339001222 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001223 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001224 superantigen-like protein 5; Reviewed; Region: PRK13035 703339001225 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001226 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001227 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 703339001228 HsdM N-terminal domain; Region: HsdM_N; pfam12161 703339001229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339001230 S-adenosylmethionine binding site [chemical binding]; other site 703339001231 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 703339001232 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 703339001233 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 703339001234 superantigen-like protein; Reviewed; Region: PRK13036 703339001235 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 703339001236 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339001237 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001238 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001239 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001240 Protein of unknown function, DUF576; Region: DUF576; cl04553 703339001241 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001242 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001243 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001244 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001245 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001246 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339001247 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 703339001248 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 703339001249 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 703339001250 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 703339001251 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 703339001252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 703339001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 703339001254 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 703339001255 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 703339001256 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 703339001257 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 703339001258 active site 703339001259 Esterase/lipase [General function prediction only]; Region: COG1647 703339001260 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 703339001261 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 703339001262 Na2 binding site [ion binding]; other site 703339001263 putative substrate binding site 1 [chemical binding]; other site 703339001264 Na binding site 1 [ion binding]; other site 703339001265 putative substrate binding site 2 [chemical binding]; other site 703339001266 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 703339001267 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 703339001268 dimer interface [polypeptide binding]; other site 703339001269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339001270 catalytic residue [active] 703339001271 cystathionine beta-lyase; Provisional; Region: PRK07671 703339001272 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 703339001273 homodimer interface [polypeptide binding]; other site 703339001274 substrate-cofactor binding pocket; other site 703339001275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339001276 catalytic residue [active] 703339001277 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 703339001278 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 703339001279 Walker A/P-loop; other site 703339001280 ATP binding site [chemical binding]; other site 703339001281 Q-loop/lid; other site 703339001282 ABC transporter signature motif; other site 703339001283 Walker B; other site 703339001284 D-loop; other site 703339001285 H-loop/switch region; other site 703339001286 NIL domain; Region: NIL; pfam09383 703339001287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339001288 dimer interface [polypeptide binding]; other site 703339001289 conserved gate region; other site 703339001290 ABC-ATPase subunit interface; other site 703339001291 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 703339001292 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 703339001293 LysM domain; Region: LysM; pfam01476 703339001294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339001295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339001296 Surface antigen [General function prediction only]; Region: COG3942 703339001297 CHAP domain; Region: CHAP; pfam05257 703339001298 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 703339001299 nudix motif; other site 703339001300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339001301 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 703339001302 Coenzyme A binding pocket [chemical binding]; other site 703339001303 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 703339001304 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 703339001305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 703339001306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 703339001307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 703339001308 dimerization interface [polypeptide binding]; other site 703339001309 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 703339001310 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 703339001311 active site 703339001312 dimer interface [polypeptide binding]; other site 703339001313 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 703339001314 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 703339001315 active site 703339001316 FMN binding site [chemical binding]; other site 703339001317 substrate binding site [chemical binding]; other site 703339001318 3Fe-4S cluster binding site [ion binding]; other site 703339001319 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 703339001320 domain interface; other site 703339001321 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 703339001322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 703339001323 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 703339001324 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339001325 active site turn [active] 703339001326 phosphorylation site [posttranslational modification] 703339001327 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339001328 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 703339001329 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 703339001330 Ca binding site [ion binding]; other site 703339001331 active site 703339001332 catalytic site [active] 703339001333 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 703339001334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339001335 DNA-binding site [nucleotide binding]; DNA binding site 703339001336 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 703339001337 UTRA domain; Region: UTRA; pfam07702 703339001338 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 703339001339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339001340 Coenzyme A binding pocket [chemical binding]; other site 703339001341 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 703339001342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339001343 Walker A motif; other site 703339001344 ATP binding site [chemical binding]; other site 703339001345 Walker B motif; other site 703339001346 arginine finger; other site 703339001347 hypothetical protein; Validated; Region: PRK00153 703339001348 recombination protein RecR; Reviewed; Region: recR; PRK00076 703339001349 RecR protein; Region: RecR; pfam02132 703339001350 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 703339001351 putative active site [active] 703339001352 putative metal-binding site [ion binding]; other site 703339001353 tetramer interface [polypeptide binding]; other site 703339001354 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 703339001355 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 703339001356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339001357 catalytic residue [active] 703339001358 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 703339001359 thymidylate kinase; Validated; Region: tmk; PRK00698 703339001360 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 703339001361 TMP-binding site; other site 703339001362 ATP-binding site [chemical binding]; other site 703339001363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 703339001364 DNA polymerase III subunit delta'; Validated; Region: PRK08058 703339001365 DNA polymerase III subunit delta'; Validated; Region: PRK08485 703339001366 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 703339001367 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 703339001368 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 703339001369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339001370 S-adenosylmethionine binding site [chemical binding]; other site 703339001371 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 703339001372 GIY-YIG motif/motif A; other site 703339001373 putative active site [active] 703339001374 putative metal binding site [ion binding]; other site 703339001375 Predicted methyltransferases [General function prediction only]; Region: COG0313 703339001376 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 703339001377 putative SAM binding site [chemical binding]; other site 703339001378 putative homodimer interface [polypeptide binding]; other site 703339001379 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 703339001380 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 703339001381 active site 703339001382 HIGH motif; other site 703339001383 KMSKS motif; other site 703339001384 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 703339001385 tRNA binding surface [nucleotide binding]; other site 703339001386 anticodon binding site; other site 703339001387 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 703339001388 dimer interface [polypeptide binding]; other site 703339001389 putative tRNA-binding site [nucleotide binding]; other site 703339001390 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 703339001391 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 703339001392 active site 703339001393 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 703339001394 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 703339001395 putative active site [active] 703339001396 putative metal binding site [ion binding]; other site 703339001397 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 703339001398 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 703339001399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339001400 S-adenosylmethionine binding site [chemical binding]; other site 703339001401 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 703339001402 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 703339001403 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 703339001404 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 703339001405 pur operon repressor; Provisional; Region: PRK09213 703339001406 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 703339001407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339001408 active site 703339001409 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 703339001410 homotrimer interaction site [polypeptide binding]; other site 703339001411 putative active site [active] 703339001412 regulatory protein SpoVG; Reviewed; Region: PRK13259 703339001413 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 703339001414 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 703339001415 Substrate binding site; other site 703339001416 Mg++ binding site; other site 703339001417 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 703339001418 active site 703339001419 substrate binding site [chemical binding]; other site 703339001420 CoA binding site [chemical binding]; other site 703339001421 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 703339001422 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 703339001423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339001424 active site 703339001425 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 703339001426 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 703339001427 5S rRNA interface [nucleotide binding]; other site 703339001428 CTC domain interface [polypeptide binding]; other site 703339001429 L16 interface [polypeptide binding]; other site 703339001430 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 703339001431 putative active site [active] 703339001432 catalytic residue [active] 703339001433 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 703339001434 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 703339001435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339001436 ATP binding site [chemical binding]; other site 703339001437 putative Mg++ binding site [ion binding]; other site 703339001438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339001439 nucleotide binding region [chemical binding]; other site 703339001440 ATP-binding site [chemical binding]; other site 703339001441 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 703339001442 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 703339001443 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 703339001444 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 703339001445 putative SAM binding site [chemical binding]; other site 703339001446 putative homodimer interface [polypeptide binding]; other site 703339001447 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 703339001448 homodimer interface [polypeptide binding]; other site 703339001449 metal binding site [ion binding]; metal-binding site 703339001450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339001451 RNA binding surface [nucleotide binding]; other site 703339001452 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 703339001453 Septum formation initiator; Region: DivIC; pfam04977 703339001454 hypothetical protein; Provisional; Region: PRK08582 703339001455 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 703339001456 RNA binding site [nucleotide binding]; other site 703339001457 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 703339001458 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 703339001459 Ligand Binding Site [chemical binding]; other site 703339001460 TilS substrate C-terminal domain; Region: TilS_C; smart00977 703339001461 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 703339001462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339001463 active site 703339001464 FtsH Extracellular; Region: FtsH_ext; pfam06480 703339001465 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 703339001466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339001467 Walker A motif; other site 703339001468 ATP binding site [chemical binding]; other site 703339001469 Walker B motif; other site 703339001470 arginine finger; other site 703339001471 Peptidase family M41; Region: Peptidase_M41; pfam01434 703339001472 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 703339001473 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 703339001474 dimerization interface [polypeptide binding]; other site 703339001475 domain crossover interface; other site 703339001476 redox-dependent activation switch; other site 703339001477 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 703339001478 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 703339001479 dimer interface [polypeptide binding]; other site 703339001480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339001481 catalytic residue [active] 703339001482 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 703339001483 dihydropteroate synthase; Region: DHPS; TIGR01496 703339001484 substrate binding pocket [chemical binding]; other site 703339001485 dimer interface [polypeptide binding]; other site 703339001486 inhibitor binding site; inhibition site 703339001487 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 703339001488 homooctamer interface [polypeptide binding]; other site 703339001489 active site 703339001490 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 703339001491 catalytic center binding site [active] 703339001492 ATP binding site [chemical binding]; other site 703339001493 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 703339001494 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 703339001495 dimer interface [polypeptide binding]; other site 703339001496 putative anticodon binding site; other site 703339001497 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 703339001498 motif 1; other site 703339001499 active site 703339001500 motif 2; other site 703339001501 motif 3; other site 703339001502 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 703339001503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339001504 DNA-binding site [nucleotide binding]; DNA binding site 703339001505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339001506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339001507 homodimer interface [polypeptide binding]; other site 703339001508 catalytic residue [active] 703339001509 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 703339001510 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 703339001511 active site 703339001512 multimer interface [polypeptide binding]; other site 703339001513 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 703339001514 predicted active site [active] 703339001515 catalytic triad [active] 703339001516 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 703339001517 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 703339001518 Nucleoside recognition; Region: Gate; pfam07670 703339001519 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 703339001520 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 703339001521 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 703339001522 UvrB/uvrC motif; Region: UVR; pfam02151 703339001523 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 703339001524 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 703339001525 ADP binding site [chemical binding]; other site 703339001526 phosphagen binding site; other site 703339001527 substrate specificity loop; other site 703339001528 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 703339001529 Clp amino terminal domain; Region: Clp_N; pfam02861 703339001530 Clp amino terminal domain; Region: Clp_N; pfam02861 703339001531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339001532 Walker A motif; other site 703339001533 ATP binding site [chemical binding]; other site 703339001534 Walker B motif; other site 703339001535 arginine finger; other site 703339001536 UvrB/uvrC motif; Region: UVR; pfam02151 703339001537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339001538 Walker A motif; other site 703339001539 ATP binding site [chemical binding]; other site 703339001540 Walker B motif; other site 703339001541 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 703339001542 DNA repair protein RadA; Provisional; Region: PRK11823 703339001543 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 703339001544 Walker A motif/ATP binding site; other site 703339001545 ATP binding site [chemical binding]; other site 703339001546 Walker B motif; other site 703339001547 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 703339001548 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 703339001549 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 703339001550 putative active site [active] 703339001551 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 703339001552 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 703339001553 active site 703339001554 HIGH motif; other site 703339001555 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 703339001556 active site 703339001557 KMSKS motif; other site 703339001558 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 703339001559 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 703339001560 trimer interface [polypeptide binding]; other site 703339001561 active site 703339001562 substrate binding site [chemical binding]; other site 703339001563 CoA binding site [chemical binding]; other site 703339001564 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 703339001565 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 703339001566 active site 703339001567 HIGH motif; other site 703339001568 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 703339001569 KMSKS motif; other site 703339001570 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 703339001571 tRNA binding surface [nucleotide binding]; other site 703339001572 anticodon binding site; other site 703339001573 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 703339001574 active site 703339001575 dimerization interface [polypeptide binding]; other site 703339001576 metal binding site [ion binding]; metal-binding site 703339001577 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 703339001578 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 703339001579 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 703339001580 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 703339001581 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 703339001582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 703339001583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 703339001584 DNA binding residues [nucleotide binding] 703339001585 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 703339001586 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 703339001587 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 703339001588 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 703339001589 putative homodimer interface [polypeptide binding]; other site 703339001590 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 703339001591 heterodimer interface [polypeptide binding]; other site 703339001592 homodimer interface [polypeptide binding]; other site 703339001593 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 703339001594 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 703339001595 23S rRNA interface [nucleotide binding]; other site 703339001596 L7/L12 interface [polypeptide binding]; other site 703339001597 putative thiostrepton binding site; other site 703339001598 L25 interface [polypeptide binding]; other site 703339001599 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 703339001600 mRNA/rRNA interface [nucleotide binding]; other site 703339001601 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 703339001602 23S rRNA interface [nucleotide binding]; other site 703339001603 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 703339001604 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 703339001605 peripheral dimer interface [polypeptide binding]; other site 703339001606 core dimer interface [polypeptide binding]; other site 703339001607 L10 interface [polypeptide binding]; other site 703339001608 L11 interface [polypeptide binding]; other site 703339001609 putative EF-Tu interaction site [polypeptide binding]; other site 703339001610 putative EF-G interaction site [polypeptide binding]; other site 703339001611 Methyltransferase domain; Region: Methyltransf_31; pfam13847 703339001612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339001613 S-adenosylmethionine binding site [chemical binding]; other site 703339001614 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 703339001615 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 703339001616 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 703339001617 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 703339001618 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 703339001619 RPB10 interaction site [polypeptide binding]; other site 703339001620 RPB1 interaction site [polypeptide binding]; other site 703339001621 RPB11 interaction site [polypeptide binding]; other site 703339001622 RPB3 interaction site [polypeptide binding]; other site 703339001623 RPB12 interaction site [polypeptide binding]; other site 703339001624 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 703339001625 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 703339001626 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 703339001627 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 703339001628 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 703339001629 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 703339001630 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 703339001631 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 703339001632 G-loop; other site 703339001633 DNA binding site [nucleotide binding] 703339001634 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 703339001635 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 703339001636 S17 interaction site [polypeptide binding]; other site 703339001637 S8 interaction site; other site 703339001638 16S rRNA interaction site [nucleotide binding]; other site 703339001639 streptomycin interaction site [chemical binding]; other site 703339001640 23S rRNA interaction site [nucleotide binding]; other site 703339001641 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 703339001642 30S ribosomal protein S7; Validated; Region: PRK05302 703339001643 elongation factor G; Reviewed; Region: PRK00007 703339001644 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 703339001645 G1 box; other site 703339001646 putative GEF interaction site [polypeptide binding]; other site 703339001647 GTP/Mg2+ binding site [chemical binding]; other site 703339001648 Switch I region; other site 703339001649 G2 box; other site 703339001650 G3 box; other site 703339001651 Switch II region; other site 703339001652 G4 box; other site 703339001653 G5 box; other site 703339001654 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 703339001655 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 703339001656 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 703339001657 elongation factor Tu; Reviewed; Region: PRK00049 703339001658 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 703339001659 G1 box; other site 703339001660 GEF interaction site [polypeptide binding]; other site 703339001661 GTP/Mg2+ binding site [chemical binding]; other site 703339001662 Switch I region; other site 703339001663 G2 box; other site 703339001664 G3 box; other site 703339001665 Switch II region; other site 703339001666 G4 box; other site 703339001667 G5 box; other site 703339001668 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 703339001669 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 703339001670 Antibiotic Binding Site [chemical binding]; other site 703339001671 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 703339001672 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 703339001673 metal binding site [ion binding]; metal-binding site 703339001674 dimer interface [polypeptide binding]; other site 703339001675 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 703339001676 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 703339001677 substrate-cofactor binding pocket; other site 703339001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339001679 catalytic residue [active] 703339001680 chaperone protein HchA; Provisional; Region: PRK04155 703339001681 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 703339001682 dimer interface [polypeptide binding]; other site 703339001683 metal binding site [ion binding]; metal-binding site 703339001684 potential oxyanion hole; other site 703339001685 potential catalytic triad [active] 703339001686 conserved cys residue [active] 703339001687 ribulokinase; Provisional; Region: PRK04123 703339001688 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 703339001689 N- and C-terminal domain interface [polypeptide binding]; other site 703339001690 active site 703339001691 MgATP binding site [chemical binding]; other site 703339001692 catalytic site [active] 703339001693 metal binding site [ion binding]; metal-binding site 703339001694 carbohydrate binding site [chemical binding]; other site 703339001695 homodimer interface [polypeptide binding]; other site 703339001696 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 703339001697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339001698 NAD(P) binding site [chemical binding]; other site 703339001699 active site 703339001700 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 703339001701 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 703339001702 homodimer interface [polypeptide binding]; other site 703339001703 substrate-cofactor binding pocket; other site 703339001704 catalytic residue [active] 703339001705 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 703339001706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339001707 motif II; other site 703339001708 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 703339001709 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 703339001710 Substrate-binding site [chemical binding]; other site 703339001711 Substrate specificity [chemical binding]; other site 703339001712 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 703339001713 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 703339001714 Substrate-binding site [chemical binding]; other site 703339001715 Substrate specificity [chemical binding]; other site 703339001716 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 703339001717 nucleoside/Zn binding site; other site 703339001718 dimer interface [polypeptide binding]; other site 703339001719 catalytic motif [active] 703339001720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339001721 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 703339001722 active site 703339001723 motif I; other site 703339001724 motif II; other site 703339001725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339001726 Predicted flavoprotein [General function prediction only]; Region: COG0431 703339001727 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 703339001728 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339001729 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339001730 Cna protein B-type domain; Region: Cna_B; pfam05738 703339001731 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001732 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339001733 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339001734 Cna protein B-type domain; Region: Cna_B; pfam05738 703339001735 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001736 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001737 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001738 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001739 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339001740 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339001741 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001742 Cna protein B-type domain; Region: Cna_B; pfam05738 703339001743 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 703339001744 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 703339001745 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 703339001746 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 703339001747 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 703339001748 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 703339001749 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 703339001750 putative GTP cyclohydrolase; Provisional; Region: PRK13674 703339001751 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 703339001752 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 703339001753 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 703339001754 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 703339001755 active site 703339001756 trimer interface [polypeptide binding]; other site 703339001757 allosteric site; other site 703339001758 active site lid [active] 703339001759 hexamer (dimer of trimers) interface [polypeptide binding]; other site 703339001760 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 703339001761 active site 703339001762 dimer interface [polypeptide binding]; other site 703339001763 magnesium binding site [ion binding]; other site 703339001764 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 703339001765 tetramer interface [polypeptide binding]; other site 703339001766 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 703339001767 active site 703339001768 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 703339001769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339001770 motif II; other site 703339001771 proline/glycine betaine transporter; Provisional; Region: PRK10642 703339001772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339001773 putative substrate translocation pore; other site 703339001774 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 703339001775 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 703339001776 acyl-activating enzyme (AAE) consensus motif; other site 703339001777 AMP binding site [chemical binding]; other site 703339001778 active site 703339001779 CoA binding site [chemical binding]; other site 703339001780 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 703339001781 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 703339001782 dimer interface [polypeptide binding]; other site 703339001783 active site 703339001784 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 703339001785 dimer interface [polypeptide binding]; other site 703339001786 substrate binding site [chemical binding]; other site 703339001787 ATP binding site [chemical binding]; other site 703339001788 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 703339001789 ligand binding site [chemical binding]; other site 703339001790 active site 703339001791 UGI interface [polypeptide binding]; other site 703339001792 catalytic site [active] 703339001793 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 703339001794 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 703339001795 Uncharacterized conserved protein [Function unknown]; Region: COG3610 703339001796 Uncharacterized conserved protein [Function unknown]; Region: COG2966 703339001797 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 703339001798 putative heme peroxidase; Provisional; Region: PRK12276 703339001799 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 703339001800 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 703339001801 mevalonate kinase; Region: mevalon_kin; TIGR00549 703339001802 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 703339001803 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 703339001804 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 703339001805 diphosphomevalonate decarboxylase; Region: PLN02407 703339001806 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 703339001807 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 703339001808 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 703339001809 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 703339001810 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 703339001811 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 703339001812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339001813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 703339001814 Predicted transcriptional regulator [Transcription]; Region: COG1959 703339001815 Transcriptional regulator; Region: Rrf2; pfam02082 703339001816 LXG domain of WXG superfamily; Region: LXG; pfam04740 703339001817 Protein of unknown function (DUF443); Region: DUF443; pfam04276 703339001818 Protein of unknown function (DUF443); Region: DUF443; pfam04276 703339001819 Protein of unknown function (DUF443); Region: DUF443; pfam04276 703339001820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 703339001821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 703339001822 active site 703339001823 catalytic tetrad [active] 703339001824 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 703339001825 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 703339001826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 703339001827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339001828 Coenzyme A binding pocket [chemical binding]; other site 703339001829 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 703339001830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 703339001831 Zn2+ binding site [ion binding]; other site 703339001832 Mg2+ binding site [ion binding]; other site 703339001833 YwhD family; Region: YwhD; pfam08741 703339001834 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 703339001835 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 703339001836 NAD binding site [chemical binding]; other site 703339001837 substrate binding site [chemical binding]; other site 703339001838 catalytic Zn binding site [ion binding]; other site 703339001839 tetramer interface [polypeptide binding]; other site 703339001840 structural Zn binding site [ion binding]; other site 703339001841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 703339001842 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 703339001843 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 703339001844 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 703339001845 active site 703339001846 HIGH motif; other site 703339001847 KMSK motif region; other site 703339001848 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 703339001849 tRNA binding surface [nucleotide binding]; other site 703339001850 anticodon binding site; other site 703339001851 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 703339001852 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 703339001853 minor groove reading motif; other site 703339001854 helix-hairpin-helix signature motif; other site 703339001855 substrate binding pocket [chemical binding]; other site 703339001856 active site 703339001857 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 703339001858 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 703339001859 putative binding site residues; other site 703339001860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339001861 ABC-ATPase subunit interface; other site 703339001862 dimer interface [polypeptide binding]; other site 703339001863 putative PBP binding regions; other site 703339001864 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 703339001865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339001866 motif II; other site 703339001867 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 703339001868 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 703339001869 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 703339001870 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 703339001871 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339001872 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339001873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 703339001874 Protein of unknown function, DUF606; Region: DUF606; pfam04657 703339001875 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 703339001876 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 703339001877 active site 703339001878 DNA binding site [nucleotide binding] 703339001879 Int/Topo IB signature motif; other site 703339001880 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 703339001881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 703339001882 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 703339001883 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 703339001884 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 703339001885 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 703339001886 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 703339001887 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 703339001888 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 703339001889 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 703339001890 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 703339001891 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 703339001892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 703339001893 Transposase; Region: DDE_Tnp_ISL3; pfam01610 703339001894 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 703339001895 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 703339001896 metal binding site [ion binding]; metal-binding site 703339001897 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 703339001898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339001899 ABC-ATPase subunit interface; other site 703339001900 dimer interface [polypeptide binding]; other site 703339001901 putative PBP binding regions; other site 703339001902 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 703339001903 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 703339001904 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 703339001905 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 703339001906 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 703339001907 FeoA domain; Region: FeoA; pfam04023 703339001908 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 703339001909 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 703339001910 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 703339001911 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 703339001912 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 703339001913 Walker A/P-loop; other site 703339001914 ATP binding site [chemical binding]; other site 703339001915 Q-loop/lid; other site 703339001916 ABC transporter signature motif; other site 703339001917 Walker B; other site 703339001918 D-loop; other site 703339001919 H-loop/switch region; other site 703339001920 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 703339001921 ABC-2 type transporter; Region: ABC2_membrane; cl17235 703339001922 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 703339001923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 703339001924 active site 703339001925 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 703339001926 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 703339001927 active site 703339001928 nucleotide binding site [chemical binding]; other site 703339001929 HIGH motif; other site 703339001930 KMSKS motif; other site 703339001931 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 703339001932 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 703339001933 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 703339001934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 703339001935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 703339001936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339001937 Walker A/P-loop; other site 703339001938 ATP binding site [chemical binding]; other site 703339001939 Q-loop/lid; other site 703339001940 ABC transporter signature motif; other site 703339001941 Walker B; other site 703339001942 D-loop; other site 703339001943 H-loop/switch region; other site 703339001944 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 703339001945 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 703339001946 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 703339001947 Uncharacterized conserved protein [Function unknown]; Region: COG1284 703339001948 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 703339001949 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 703339001950 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 703339001951 Walker A/P-loop; other site 703339001952 ATP binding site [chemical binding]; other site 703339001953 Q-loop/lid; other site 703339001954 ABC transporter signature motif; other site 703339001955 Walker B; other site 703339001956 D-loop; other site 703339001957 H-loop/switch region; other site 703339001958 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 703339001959 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339001960 ABC-ATPase subunit interface; other site 703339001961 dimer interface [polypeptide binding]; other site 703339001962 putative PBP binding regions; other site 703339001963 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 703339001964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339001965 ABC-ATPase subunit interface; other site 703339001966 dimer interface [polypeptide binding]; other site 703339001967 putative PBP binding regions; other site 703339001968 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 703339001969 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 703339001970 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 703339001971 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 703339001972 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 703339001973 Uncharacterized membrane protein [Function unknown]; Region: COG3949 703339001974 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 703339001975 Na binding site [ion binding]; other site 703339001976 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 703339001977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 703339001978 substrate binding pocket [chemical binding]; other site 703339001979 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 703339001980 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 703339001981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339001982 Coenzyme A binding pocket [chemical binding]; other site 703339001983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339001984 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 703339001985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339001986 NAD(P) binding site [chemical binding]; other site 703339001987 active site 703339001988 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339001989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339001990 active site 703339001991 phosphorylation site [posttranslational modification] 703339001992 intermolecular recognition site; other site 703339001993 dimerization interface [polypeptide binding]; other site 703339001994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339001995 DNA binding site [nucleotide binding] 703339001996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 703339001997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 703339001998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339001999 ATP binding site [chemical binding]; other site 703339002000 Mg2+ binding site [ion binding]; other site 703339002001 G-X-G motif; other site 703339002002 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 703339002003 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339002004 Walker A/P-loop; other site 703339002005 ATP binding site [chemical binding]; other site 703339002006 Q-loop/lid; other site 703339002007 ABC transporter signature motif; other site 703339002008 Walker B; other site 703339002009 D-loop; other site 703339002010 H-loop/switch region; other site 703339002011 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 703339002012 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 703339002013 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339002014 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 703339002015 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339002016 Surface antigen [General function prediction only]; Region: COG3942 703339002017 CHAP domain; Region: CHAP; pfam05257 703339002018 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 703339002019 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 703339002020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 703339002021 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339002022 Transcriptional regulator; Region: Transcrip_reg; cl00361 703339002023 Uncharacterized conserved protein [Function unknown]; Region: COG3542 703339002024 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 703339002025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 703339002026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 703339002027 dimerization interface [polypeptide binding]; other site 703339002028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339002029 sugar efflux transporter; Region: 2A0120; TIGR00899 703339002030 putative substrate translocation pore; other site 703339002031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 703339002032 Serine incorporator (Serinc); Region: Serinc; pfam03348 703339002033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339002034 Coenzyme A binding pocket [chemical binding]; other site 703339002035 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 703339002036 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 703339002037 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 703339002038 hypothetical protein; Validated; Region: PRK00124 703339002039 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 703339002040 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 703339002041 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 703339002042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 703339002043 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 703339002044 Walker A/P-loop; other site 703339002045 ATP binding site [chemical binding]; other site 703339002046 Q-loop/lid; other site 703339002047 ABC transporter signature motif; other site 703339002048 Walker B; other site 703339002049 D-loop; other site 703339002050 H-loop/switch region; other site 703339002051 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 703339002052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 703339002053 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 703339002054 Walker A/P-loop; other site 703339002055 ATP binding site [chemical binding]; other site 703339002056 Q-loop/lid; other site 703339002057 ABC transporter signature motif; other site 703339002058 Walker B; other site 703339002059 D-loop; other site 703339002060 H-loop/switch region; other site 703339002061 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339002062 MarR family; Region: MarR; pfam01047 703339002063 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 703339002064 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 703339002065 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 703339002066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 703339002067 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 703339002068 active site 703339002069 catalytic tetrad [active] 703339002070 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 703339002071 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 703339002072 transmembrane helices; other site 703339002073 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 703339002074 DNA photolyase; Region: DNA_photolyase; pfam00875 703339002075 Predicted membrane protein [Function unknown]; Region: COG4330 703339002076 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 703339002077 trimer interface [polypeptide binding]; other site 703339002078 putative Zn binding site [ion binding]; other site 703339002079 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 703339002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339002081 putative substrate translocation pore; other site 703339002082 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 703339002083 putative deacylase active site [active] 703339002084 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 703339002085 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 703339002086 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 703339002087 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 703339002088 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 703339002089 putative substrate binding site [chemical binding]; other site 703339002090 putative ATP binding site [chemical binding]; other site 703339002091 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 703339002092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339002093 active site 703339002094 phosphorylation site [posttranslational modification] 703339002095 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 703339002096 active site 703339002097 P-loop; other site 703339002098 phosphorylation site [posttranslational modification] 703339002099 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 703339002100 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 703339002101 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 703339002102 active site 703339002103 dimer interface [polypeptide binding]; other site 703339002104 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 703339002105 Domain of unknown function DUF21; Region: DUF21; pfam01595 703339002106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 703339002107 Transporter associated domain; Region: CorC_HlyC; pfam03471 703339002108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 703339002109 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 703339002110 active site 703339002111 catalytic tetrad [active] 703339002112 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 703339002113 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 703339002114 Ligand binding site; other site 703339002115 Putative Catalytic site; other site 703339002116 DXD motif; other site 703339002117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 703339002118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339002119 dimer interface [polypeptide binding]; other site 703339002120 phosphorylation site [posttranslational modification] 703339002121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339002122 ATP binding site [chemical binding]; other site 703339002123 Mg2+ binding site [ion binding]; other site 703339002124 G-X-G motif; other site 703339002125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339002126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339002127 active site 703339002128 phosphorylation site [posttranslational modification] 703339002129 intermolecular recognition site; other site 703339002130 dimerization interface [polypeptide binding]; other site 703339002131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339002132 DNA binding site [nucleotide binding] 703339002133 Electron transfer DM13; Region: DM13; pfam10517 703339002134 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 703339002135 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 703339002136 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 703339002137 active site 703339002138 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 703339002139 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 703339002140 Ligand Binding Site [chemical binding]; other site 703339002141 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 703339002142 Glutamine amidotransferase class-I; Region: GATase; pfam00117 703339002143 glutamine binding [chemical binding]; other site 703339002144 catalytic triad [active] 703339002145 aminodeoxychorismate synthase; Provisional; Region: PRK07508 703339002146 chorismate binding enzyme; Region: Chorismate_bind; cl10555 703339002147 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 703339002148 substrate-cofactor binding pocket; other site 703339002149 Aminotransferase class IV; Region: Aminotran_4; pfam01063 703339002150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339002151 catalytic residue [active] 703339002152 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 703339002153 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 703339002154 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 703339002155 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 703339002156 Sulfatase; Region: Sulfatase; pfam00884 703339002157 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 703339002158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339002159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339002160 ABC transporter; Region: ABC_tran_2; pfam12848 703339002161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339002162 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 703339002163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339002164 ATP binding site [chemical binding]; other site 703339002165 putative Mg++ binding site [ion binding]; other site 703339002166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339002167 nucleotide binding region [chemical binding]; other site 703339002168 ATP-binding site [chemical binding]; other site 703339002169 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 703339002170 HRDC domain; Region: HRDC; pfam00570 703339002171 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 703339002172 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 703339002173 Walker A/P-loop; other site 703339002174 ATP binding site [chemical binding]; other site 703339002175 Q-loop/lid; other site 703339002176 ABC transporter signature motif; other site 703339002177 Walker B; other site 703339002178 D-loop; other site 703339002179 H-loop/switch region; other site 703339002180 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 703339002181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339002182 dimer interface [polypeptide binding]; other site 703339002183 conserved gate region; other site 703339002184 ABC-ATPase subunit interface; other site 703339002185 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 703339002186 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 703339002187 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 703339002188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339002189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339002190 homodimer interface [polypeptide binding]; other site 703339002191 catalytic residue [active] 703339002192 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339002193 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 703339002194 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 703339002195 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 703339002196 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 703339002197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339002198 putative substrate translocation pore; other site 703339002199 POT family; Region: PTR2; cl17359 703339002200 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 703339002201 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 703339002202 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 703339002203 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 703339002204 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 703339002205 Class I ribonucleotide reductase; Region: RNR_I; cd01679 703339002206 active site 703339002207 dimer interface [polypeptide binding]; other site 703339002208 catalytic residues [active] 703339002209 effector binding site; other site 703339002210 R2 peptide binding site; other site 703339002211 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 703339002212 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 703339002213 dimer interface [polypeptide binding]; other site 703339002214 putative radical transfer pathway; other site 703339002215 diiron center [ion binding]; other site 703339002216 tyrosyl radical; other site 703339002217 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339002218 ABC-ATPase subunit interface; other site 703339002219 dimer interface [polypeptide binding]; other site 703339002220 putative PBP binding regions; other site 703339002221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339002222 ABC-ATPase subunit interface; other site 703339002223 dimer interface [polypeptide binding]; other site 703339002224 putative PBP binding regions; other site 703339002225 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 703339002226 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 703339002227 Walker A/P-loop; other site 703339002228 ATP binding site [chemical binding]; other site 703339002229 Q-loop/lid; other site 703339002230 ABC transporter signature motif; other site 703339002231 Walker B; other site 703339002232 D-loop; other site 703339002233 H-loop/switch region; other site 703339002234 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 703339002235 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 703339002236 putative ligand binding residues [chemical binding]; other site 703339002237 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 703339002238 CHY zinc finger; Region: zf-CHY; pfam05495 703339002239 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 703339002240 FAD binding domain; Region: FAD_binding_4; pfam01565 703339002241 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 703339002242 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 703339002243 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 703339002244 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 703339002245 peptidase T; Region: peptidase-T; TIGR01882 703339002246 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 703339002247 metal binding site [ion binding]; metal-binding site 703339002248 dimer interface [polypeptide binding]; other site 703339002249 Uncharacterized conserved protein [Function unknown]; Region: COG3610 703339002250 Uncharacterized conserved protein [Function unknown]; Region: COG2966 703339002251 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 703339002252 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 703339002253 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 703339002254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 703339002255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 703339002256 metal binding site [ion binding]; metal-binding site 703339002257 active site 703339002258 I-site; other site 703339002259 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 703339002260 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 703339002261 Mg++ binding site [ion binding]; other site 703339002262 putative catalytic motif [active] 703339002263 substrate binding site [chemical binding]; other site 703339002264 Uncharacterized conserved protein [Function unknown]; Region: COG1739 703339002265 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 703339002266 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 703339002267 EDD domain protein, DegV family; Region: DegV; TIGR00762 703339002268 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 703339002269 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 703339002270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 703339002271 putative Mg++ binding site [ion binding]; other site 703339002272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339002273 nucleotide binding region [chemical binding]; other site 703339002274 ATP-binding site [chemical binding]; other site 703339002275 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 703339002276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339002277 active site 703339002278 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 703339002279 30S subunit binding site; other site 703339002280 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 703339002281 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 703339002282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 703339002283 nucleotide binding region [chemical binding]; other site 703339002284 ATP-binding site [chemical binding]; other site 703339002285 SEC-C motif; Region: SEC-C; pfam02810 703339002286 peptide chain release factor 2; Provisional; Region: PRK06746 703339002287 This domain is found in peptide chain release factors; Region: PCRF; smart00937 703339002288 RF-1 domain; Region: RF-1; pfam00472 703339002289 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 703339002290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339002291 Surface antigen [General function prediction only]; Region: COG3942 703339002292 CHAP domain; Region: CHAP; pfam05257 703339002293 HD domain; Region: HD_3; cl17350 703339002294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 703339002295 excinuclease ABC subunit B; Provisional; Region: PRK05298 703339002296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339002297 ATP binding site [chemical binding]; other site 703339002298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339002299 nucleotide binding region [chemical binding]; other site 703339002300 ATP-binding site [chemical binding]; other site 703339002301 Ultra-violet resistance protein B; Region: UvrB; pfam12344 703339002302 UvrB/uvrC motif; Region: UVR; pfam02151 703339002303 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 703339002304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 703339002305 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 703339002306 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 703339002307 HPr kinase/phosphorylase; Provisional; Region: PRK05428 703339002308 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 703339002309 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 703339002310 Hpr binding site; other site 703339002311 active site 703339002312 homohexamer subunit interaction site [polypeptide binding]; other site 703339002313 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 703339002314 putative acyl transferase; Provisional; Region: PRK10191 703339002315 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 703339002316 trimer interface [polypeptide binding]; other site 703339002317 active site 703339002318 substrate binding site [chemical binding]; other site 703339002319 CoA binding site [chemical binding]; other site 703339002320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 703339002321 binding surface 703339002322 TPR motif; other site 703339002323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 703339002324 TPR motif; other site 703339002325 binding surface 703339002326 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 703339002327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 703339002328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339002329 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 703339002330 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 703339002331 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 703339002332 phosphate binding site [ion binding]; other site 703339002333 dimer interface [polypeptide binding]; other site 703339002334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 703339002335 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 703339002336 Clp protease; Region: CLP_protease; pfam00574 703339002337 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 703339002338 oligomer interface [polypeptide binding]; other site 703339002339 active site residues [active] 703339002340 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 703339002341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339002342 NAD(P) binding site [chemical binding]; other site 703339002343 active site 703339002344 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 703339002345 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 703339002346 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 703339002347 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 703339002348 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 703339002349 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 703339002350 Phosphoglycerate kinase; Region: PGK; pfam00162 703339002351 substrate binding site [chemical binding]; other site 703339002352 hinge regions; other site 703339002353 ADP binding site [chemical binding]; other site 703339002354 catalytic site [active] 703339002355 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 703339002356 triosephosphate isomerase; Provisional; Region: PRK14565 703339002357 substrate binding site [chemical binding]; other site 703339002358 dimer interface [polypeptide binding]; other site 703339002359 catalytic triad [active] 703339002360 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 703339002361 phosphoglyceromutase; Provisional; Region: PRK05434 703339002362 enolase; Provisional; Region: eno; PRK00077 703339002363 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 703339002364 dimer interface [polypeptide binding]; other site 703339002365 metal binding site [ion binding]; metal-binding site 703339002366 substrate binding pocket [chemical binding]; other site 703339002367 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 703339002368 Esterase/lipase [General function prediction only]; Region: COG1647 703339002369 ribonuclease R; Region: RNase_R; TIGR02063 703339002370 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 703339002371 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 703339002372 RNB domain; Region: RNB; pfam00773 703339002373 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 703339002374 RNA binding site [nucleotide binding]; other site 703339002375 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 703339002376 SmpB-tmRNA interface; other site 703339002377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339002378 Coenzyme A binding pocket [chemical binding]; other site 703339002379 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339002380 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339002381 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 703339002382 Staphylococcal nuclease homologues; Region: SNc; smart00318 703339002383 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 703339002384 Catalytic site; other site 703339002385 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 703339002386 DNA-binding site [nucleotide binding]; DNA binding site 703339002387 RNA-binding motif; other site 703339002388 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 703339002389 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 703339002390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 703339002391 catalytic core [active] 703339002392 Lysine efflux permease [General function prediction only]; Region: COG1279 703339002393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339002394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 703339002395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339002396 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 703339002397 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 703339002398 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 703339002399 active site 703339002400 catalytic residue [active] 703339002401 dimer interface [polypeptide binding]; other site 703339002402 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 703339002403 putative FMN binding site [chemical binding]; other site 703339002404 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 703339002405 catalytic residues [active] 703339002406 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 703339002407 ArsC family; Region: ArsC; pfam03960 703339002408 putative ArsC-like catalytic residues; other site 703339002409 putative TRX-like catalytic residues [active] 703339002410 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 703339002411 lipoyl attachment site [posttranslational modification]; other site 703339002412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 703339002413 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 703339002414 putative active site [active] 703339002415 putative metal binding site [ion binding]; other site 703339002416 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 703339002417 catalytic residues [active] 703339002418 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 703339002419 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 703339002420 Walker A/P-loop; other site 703339002421 ATP binding site [chemical binding]; other site 703339002422 Q-loop/lid; other site 703339002423 ABC transporter signature motif; other site 703339002424 Walker B; other site 703339002425 D-loop; other site 703339002426 H-loop/switch region; other site 703339002427 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 703339002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339002429 dimer interface [polypeptide binding]; other site 703339002430 conserved gate region; other site 703339002431 ABC-ATPase subunit interface; other site 703339002432 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 703339002433 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 703339002434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 703339002435 Predicted membrane protein [Function unknown]; Region: COG2035 703339002436 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 703339002437 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 703339002438 Walker A/P-loop; other site 703339002439 ATP binding site [chemical binding]; other site 703339002440 Q-loop/lid; other site 703339002441 ABC transporter signature motif; other site 703339002442 Walker B; other site 703339002443 D-loop; other site 703339002444 H-loop/switch region; other site 703339002445 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 703339002446 FeS assembly protein SufD; Region: sufD; TIGR01981 703339002447 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 703339002448 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 703339002449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339002450 catalytic residue [active] 703339002451 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 703339002452 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 703339002453 trimerization site [polypeptide binding]; other site 703339002454 active site 703339002455 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 703339002456 FeS assembly protein SufB; Region: sufB; TIGR01980 703339002457 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 703339002458 active site 703339002459 DNA binding site [nucleotide binding] 703339002460 Int/Topo IB signature motif; other site 703339002461 Short C-terminal domain; Region: SHOCT; pfam09851 703339002462 Domain of unknown function (DUF955); Region: DUF955; pfam06114 703339002463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 703339002464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339002465 non-specific DNA binding site [nucleotide binding]; other site 703339002466 salt bridge; other site 703339002467 sequence-specific DNA binding site [nucleotide binding]; other site 703339002468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339002469 non-specific DNA binding site [nucleotide binding]; other site 703339002470 salt bridge; other site 703339002471 sequence-specific DNA binding site [nucleotide binding]; other site 703339002472 BRO family, N-terminal domain; Region: Bro-N; smart01040 703339002473 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 703339002474 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 703339002475 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 703339002476 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 703339002477 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 703339002478 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 703339002479 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 703339002480 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 703339002481 dimer interface [polypeptide binding]; other site 703339002482 ssDNA binding site [nucleotide binding]; other site 703339002483 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339002484 Protein of unknown function (DUF968); Region: DUF968; pfam06147 703339002485 Helix-turn-helix domain; Region: HTH_36; pfam13730 703339002486 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 703339002487 hypothetical protein; Validated; Region: PRK08116 703339002488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339002489 Walker A motif; other site 703339002490 ATP binding site [chemical binding]; other site 703339002491 Walker B motif; other site 703339002492 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 703339002493 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 703339002494 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 703339002495 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 703339002496 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 703339002497 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 703339002498 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 703339002499 trimer interface [polypeptide binding]; other site 703339002500 active site 703339002501 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 703339002502 Transcriptional activator RinB; Region: RinB; pfam06116 703339002503 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 703339002504 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 703339002505 Terminase small subunit; Region: Terminase_2; pfam03592 703339002506 Phage terminase large subunit; Region: Terminase_3; cl12054 703339002507 Terminase-like family; Region: Terminase_6; pfam03237 703339002508 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 703339002509 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 703339002510 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 703339002511 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 703339002512 Phage capsid family; Region: Phage_capsid; pfam05065 703339002513 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 703339002514 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 703339002515 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 703339002516 Phage protein; Region: DUF3647; pfam12363 703339002517 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 703339002518 Phage-related protein [Function unknown]; Region: COG5412 703339002519 membrane protein P6; Region: PHA01399 703339002520 Phage tail protein; Region: Sipho_tail; pfam05709 703339002521 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 703339002522 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 703339002523 active site 703339002524 catalytic triad [active] 703339002525 oxyanion hole [active] 703339002526 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 703339002527 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 703339002528 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 703339002529 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 703339002530 CHAP domain; Region: CHAP; pfam05257 703339002531 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 703339002532 Lysozyme subfamily 2; Region: LYZ2; smart00047 703339002533 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 703339002534 Phage tail repeat like; Region: PTR; pfam12789 703339002535 holin, SPP1 family; Region: holin_SPP1; TIGR01592 703339002536 CHAP domain; Region: CHAP; pfam05257 703339002537 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 703339002538 active site 703339002539 metal binding site [ion binding]; metal-binding site 703339002540 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 703339002541 Domain of unknown function DUF21; Region: DUF21; pfam01595 703339002542 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 703339002543 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 703339002544 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 703339002545 FMN binding site [chemical binding]; other site 703339002546 substrate binding site [chemical binding]; other site 703339002547 putative catalytic residue [active] 703339002548 Uncharacterized conserved protein [Function unknown]; Region: COG1801 703339002549 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 703339002550 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 703339002551 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 703339002552 active site 703339002553 metal binding site [ion binding]; metal-binding site 703339002554 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 703339002555 lipoyl synthase; Provisional; Region: PRK05481 703339002556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339002557 FeS/SAM binding site; other site 703339002558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 703339002559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 703339002560 Transposase; Region: DDE_Tnp_ISL3; pfam01610 703339002561 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 703339002562 Uncharacterized conserved protein [Function unknown]; Region: COG2445 703339002563 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 703339002564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339002565 active site 703339002566 motif I; other site 703339002567 motif II; other site 703339002568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339002569 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 703339002570 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 703339002571 dimerization interface [polypeptide binding]; other site 703339002572 ligand binding site [chemical binding]; other site 703339002573 NADP binding site [chemical binding]; other site 703339002574 catalytic site [active] 703339002575 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 703339002576 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 703339002577 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 703339002578 acyl-activating enzyme (AAE) consensus motif; other site 703339002579 AMP binding site [chemical binding]; other site 703339002580 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 703339002581 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 703339002582 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 703339002583 DltD N-terminal region; Region: DltD_N; pfam04915 703339002584 DltD central region; Region: DltD_M; pfam04918 703339002585 DltD C-terminal region; Region: DltD_C; pfam04914 703339002586 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 703339002587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 703339002588 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 703339002589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339002590 hypothetical protein; Provisional; Region: PRK13669 703339002591 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 703339002592 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 703339002593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339002594 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 703339002595 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 703339002596 interface (dimer of trimers) [polypeptide binding]; other site 703339002597 Substrate-binding/catalytic site; other site 703339002598 Zn-binding sites [ion binding]; other site 703339002599 Predicted permease [General function prediction only]; Region: COG2056 703339002600 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 703339002601 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 703339002602 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 703339002603 CoenzymeA binding site [chemical binding]; other site 703339002604 subunit interaction site [polypeptide binding]; other site 703339002605 PHB binding site; other site 703339002606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 703339002607 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 703339002608 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 703339002609 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 703339002610 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 703339002611 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 703339002612 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 703339002613 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 703339002614 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 703339002615 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 703339002616 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 703339002617 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 703339002618 Kinase associated protein B; Region: KapB; pfam08810 703339002619 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 703339002620 active site 703339002621 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 703339002622 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 703339002623 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 703339002624 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 703339002625 putative active site [active] 703339002626 putative FMN binding site [chemical binding]; other site 703339002627 putative substrate binding site [chemical binding]; other site 703339002628 putative catalytic residue [active] 703339002629 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 703339002630 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 703339002631 inhibitor-cofactor binding pocket; inhibition site 703339002632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339002633 catalytic residue [active] 703339002634 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 703339002635 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 703339002636 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 703339002637 NAD(P) binding site [chemical binding]; other site 703339002638 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 703339002639 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 703339002640 active site 703339002641 catalytic site [active] 703339002642 metal binding site [ion binding]; metal-binding site 703339002643 argininosuccinate lyase; Provisional; Region: PRK00855 703339002644 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 703339002645 active sites [active] 703339002646 tetramer interface [polypeptide binding]; other site 703339002647 argininosuccinate synthase; Provisional; Region: PRK13820 703339002648 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 703339002649 ANP binding site [chemical binding]; other site 703339002650 Substrate Binding Site II [chemical binding]; other site 703339002651 Substrate Binding Site I [chemical binding]; other site 703339002652 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 703339002653 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 703339002654 active site 703339002655 dimer interface [polypeptide binding]; other site 703339002656 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 703339002657 dimer interface [polypeptide binding]; other site 703339002658 active site 703339002659 Uncharacterized conserved protein [Function unknown]; Region: COG0398 703339002660 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 703339002661 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 703339002662 Catalytic site [active] 703339002663 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 703339002664 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 703339002665 Catalytic site [active] 703339002666 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 703339002667 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 703339002668 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 703339002669 Part of AAA domain; Region: AAA_19; pfam13245 703339002670 Family description; Region: UvrD_C_2; pfam13538 703339002671 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 703339002672 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 703339002673 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 703339002674 hypothetical protein; Provisional; Region: PRK13673 703339002675 coenzyme A disulfide reductase; Provisional; Region: PRK13512 703339002676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 703339002677 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339002678 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 703339002679 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 703339002680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339002681 active site 703339002682 motif I; other site 703339002683 motif II; other site 703339002684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339002685 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 703339002686 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 703339002687 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 703339002688 catalytic triad [active] 703339002689 catalytic triad [active] 703339002690 oxyanion hole [active] 703339002691 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 703339002692 Clp amino terminal domain; Region: Clp_N; pfam02861 703339002693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339002694 Walker A motif; other site 703339002695 ATP binding site [chemical binding]; other site 703339002696 Walker B motif; other site 703339002697 arginine finger; other site 703339002698 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 703339002699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339002700 Walker A motif; other site 703339002701 ATP binding site [chemical binding]; other site 703339002702 Walker B motif; other site 703339002703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 703339002704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 703339002705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 703339002706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 703339002707 dimerization interface [polypeptide binding]; other site 703339002708 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 703339002709 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 703339002710 active site 703339002711 catalytic residues [active] 703339002712 metal binding site [ion binding]; metal-binding site 703339002713 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 703339002714 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 703339002715 substrate binding site [chemical binding]; other site 703339002716 MAP domain; Region: MAP; pfam03642 703339002717 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 703339002718 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 703339002719 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 703339002720 dimer interface [polypeptide binding]; other site 703339002721 active site 703339002722 CoA binding pocket [chemical binding]; other site 703339002723 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 703339002724 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 703339002725 dimer interface [polypeptide binding]; other site 703339002726 active site 703339002727 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 703339002728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 703339002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339002730 dimer interface [polypeptide binding]; other site 703339002731 conserved gate region; other site 703339002732 putative PBP binding loops; other site 703339002733 ABC-ATPase subunit interface; other site 703339002734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 703339002735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339002736 dimer interface [polypeptide binding]; other site 703339002737 conserved gate region; other site 703339002738 putative PBP binding loops; other site 703339002739 ABC-ATPase subunit interface; other site 703339002740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 703339002741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339002742 Walker A/P-loop; other site 703339002743 ATP binding site [chemical binding]; other site 703339002744 Q-loop/lid; other site 703339002745 ABC transporter signature motif; other site 703339002746 Walker B; other site 703339002747 D-loop; other site 703339002748 H-loop/switch region; other site 703339002749 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 703339002750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 703339002751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339002752 Walker A/P-loop; other site 703339002753 ATP binding site [chemical binding]; other site 703339002754 Q-loop/lid; other site 703339002755 ABC transporter signature motif; other site 703339002756 Walker B; other site 703339002757 D-loop; other site 703339002758 H-loop/switch region; other site 703339002759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 703339002760 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 703339002761 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 703339002762 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 703339002763 peptide binding site [polypeptide binding]; other site 703339002764 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 703339002765 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 703339002766 peptide binding site [polypeptide binding]; other site 703339002767 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 703339002768 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339002769 Walker A/P-loop; other site 703339002770 ATP binding site [chemical binding]; other site 703339002771 Q-loop/lid; other site 703339002772 ABC transporter signature motif; other site 703339002773 Walker B; other site 703339002774 D-loop; other site 703339002775 H-loop/switch region; other site 703339002776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 703339002777 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 703339002778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339002779 Walker A/P-loop; other site 703339002780 ATP binding site [chemical binding]; other site 703339002781 Q-loop/lid; other site 703339002782 ABC transporter signature motif; other site 703339002783 Walker B; other site 703339002784 D-loop; other site 703339002785 H-loop/switch region; other site 703339002786 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 703339002787 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 703339002788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339002789 dimer interface [polypeptide binding]; other site 703339002790 conserved gate region; other site 703339002791 putative PBP binding loops; other site 703339002792 ABC-ATPase subunit interface; other site 703339002793 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 703339002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339002795 dimer interface [polypeptide binding]; other site 703339002796 conserved gate region; other site 703339002797 putative PBP binding loops; other site 703339002798 ABC-ATPase subunit interface; other site 703339002799 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 703339002800 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 703339002801 active site 703339002802 HIGH motif; other site 703339002803 dimer interface [polypeptide binding]; other site 703339002804 KMSKS motif; other site 703339002805 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 703339002806 ArsC family; Region: ArsC; pfam03960 703339002807 putative catalytic residues [active] 703339002808 thiol/disulfide switch; other site 703339002809 adaptor protein; Provisional; Region: PRK02315 703339002810 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 703339002811 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 703339002812 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 703339002813 active site 703339002814 Zn binding site [ion binding]; other site 703339002815 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 703339002816 Thioredoxin; Region: Thioredoxin_5; pfam13743 703339002817 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 703339002818 apolar tunnel; other site 703339002819 heme binding site [chemical binding]; other site 703339002820 dimerization interface [polypeptide binding]; other site 703339002821 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 703339002822 putative active site [active] 703339002823 putative metal binding residues [ion binding]; other site 703339002824 signature motif; other site 703339002825 putative triphosphate binding site [ion binding]; other site 703339002826 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 703339002827 synthetase active site [active] 703339002828 NTP binding site [chemical binding]; other site 703339002829 metal binding site [ion binding]; metal-binding site 703339002830 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 703339002831 ATP-NAD kinase; Region: NAD_kinase; pfam01513 703339002832 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 703339002833 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 703339002834 active site 703339002835 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 703339002836 MgtE intracellular N domain; Region: MgtE_N; smart00924 703339002837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 703339002838 Divalent cation transporter; Region: MgtE; pfam01769 703339002839 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 703339002840 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 703339002841 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 703339002842 TrkA-N domain; Region: TrkA_N; pfam02254 703339002843 TrkA-C domain; Region: TrkA_C; pfam02080 703339002844 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 703339002845 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 703339002846 NAD binding site [chemical binding]; other site 703339002847 homotetramer interface [polypeptide binding]; other site 703339002848 homodimer interface [polypeptide binding]; other site 703339002849 substrate binding site [chemical binding]; other site 703339002850 active site 703339002851 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 703339002852 Domain of unknown function DUF20; Region: UPF0118; pfam01594 703339002853 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 703339002854 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 703339002855 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 703339002856 Putative esterase; Region: Esterase; pfam00756 703339002857 hypothetical protein; Provisional; Region: PRK13679 703339002858 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 703339002859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339002860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339002861 putative substrate translocation pore; other site 703339002862 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 703339002863 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 703339002864 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 703339002865 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 703339002866 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 703339002867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 703339002868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 703339002869 YueH-like protein; Region: YueH; pfam14166 703339002870 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 703339002871 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 703339002872 G1 box; other site 703339002873 putative GEF interaction site [polypeptide binding]; other site 703339002874 GTP/Mg2+ binding site [chemical binding]; other site 703339002875 Switch I region; other site 703339002876 G2 box; other site 703339002877 G3 box; other site 703339002878 Switch II region; other site 703339002879 G4 box; other site 703339002880 G5 box; other site 703339002881 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 703339002882 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 703339002883 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 703339002884 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 703339002885 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 703339002886 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 703339002887 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 703339002888 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 703339002889 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 703339002890 active site 703339002891 metal binding site [ion binding]; metal-binding site 703339002892 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 703339002893 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 703339002894 IDEAL domain; Region: IDEAL; pfam08858 703339002895 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 703339002896 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 703339002897 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 703339002898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 703339002899 CAAX protease self-immunity; Region: Abi; pfam02517 703339002900 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 703339002901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 703339002902 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 703339002903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 703339002904 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339002905 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 703339002906 Walker A/P-loop; other site 703339002907 ATP binding site [chemical binding]; other site 703339002908 Q-loop/lid; other site 703339002909 ABC transporter signature motif; other site 703339002910 Walker B; other site 703339002911 D-loop; other site 703339002912 H-loop/switch region; other site 703339002913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 703339002914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 703339002915 Predicted membrane protein [Function unknown]; Region: COG2259 703339002916 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 703339002917 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 703339002918 siderophore binding site; other site 703339002919 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 703339002920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339002921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 703339002922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339002923 Coenzyme A binding pocket [chemical binding]; other site 703339002924 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 703339002925 UbiA prenyltransferase family; Region: UbiA; pfam01040 703339002926 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 703339002927 isochorismate synthases; Region: isochor_syn; TIGR00543 703339002928 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 703339002929 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 703339002930 dimer interface [polypeptide binding]; other site 703339002931 tetramer interface [polypeptide binding]; other site 703339002932 PYR/PP interface [polypeptide binding]; other site 703339002933 TPP binding site [chemical binding]; other site 703339002934 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 703339002935 TPP-binding site; other site 703339002936 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 703339002937 PGAP1-like protein; Region: PGAP1; pfam07819 703339002938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 703339002939 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 703339002940 substrate binding site [chemical binding]; other site 703339002941 oxyanion hole (OAH) forming residues; other site 703339002942 trimer interface [polypeptide binding]; other site 703339002943 Staphostatin B; Region: Staphostatin_B; pfam09023 703339002944 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 703339002945 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339002946 aminotransferase A; Validated; Region: PRK07683 703339002947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339002948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339002949 homodimer interface [polypeptide binding]; other site 703339002950 catalytic residue [active] 703339002951 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 703339002952 Acyltransferase family; Region: Acyl_transf_3; pfam01757 703339002953 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339002954 MarR family; Region: MarR; pfam01047 703339002955 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 703339002956 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 703339002957 amidase catalytic site [active] 703339002958 Zn binding residues [ion binding]; other site 703339002959 substrate binding site [chemical binding]; other site 703339002960 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 703339002961 Lysozyme subfamily 2; Region: LYZ2; smart00047 703339002962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339002963 Coenzyme A binding pocket [chemical binding]; other site 703339002964 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 703339002965 Transcriptional regulator [Transcription]; Region: LytR; COG1316 703339002966 Beta-lactamase; Region: Beta-lactamase; pfam00144 703339002967 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 703339002968 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 703339002969 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 703339002970 Subunit I/III interface [polypeptide binding]; other site 703339002971 Subunit III/IV interface [polypeptide binding]; other site 703339002972 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 703339002973 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 703339002974 D-pathway; other site 703339002975 Putative ubiquinol binding site [chemical binding]; other site 703339002976 Low-spin heme (heme b) binding site [chemical binding]; other site 703339002977 Putative water exit pathway; other site 703339002978 Binuclear center (heme o3/CuB) [ion binding]; other site 703339002979 K-pathway; other site 703339002980 Putative proton exit pathway; other site 703339002981 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 703339002982 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 703339002983 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 703339002984 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 703339002985 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339002986 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 703339002987 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 703339002988 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 703339002989 homodimer interface [polypeptide binding]; other site 703339002990 NADP binding site [chemical binding]; other site 703339002991 substrate binding site [chemical binding]; other site 703339002992 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 703339002993 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 703339002994 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 703339002995 NAD binding site [chemical binding]; other site 703339002996 ATP-grasp domain; Region: ATP-grasp; pfam02222 703339002997 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 703339002998 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 703339002999 ATP binding site [chemical binding]; other site 703339003000 active site 703339003001 substrate binding site [chemical binding]; other site 703339003002 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 703339003003 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 703339003004 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 703339003005 putative active site [active] 703339003006 catalytic triad [active] 703339003007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 703339003008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 703339003009 dimerization interface [polypeptide binding]; other site 703339003010 ATP binding site [chemical binding]; other site 703339003011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 703339003012 dimerization interface [polypeptide binding]; other site 703339003013 ATP binding site [chemical binding]; other site 703339003014 amidophosphoribosyltransferase; Provisional; Region: PRK07272 703339003015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 703339003016 active site 703339003017 tetramer interface [polypeptide binding]; other site 703339003018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339003019 active site 703339003020 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 703339003021 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 703339003022 dimerization interface [polypeptide binding]; other site 703339003023 putative ATP binding site [chemical binding]; other site 703339003024 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 703339003025 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 703339003026 active site 703339003027 substrate binding site [chemical binding]; other site 703339003028 cosubstrate binding site; other site 703339003029 catalytic site [active] 703339003030 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 703339003031 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 703339003032 purine monophosphate binding site [chemical binding]; other site 703339003033 dimer interface [polypeptide binding]; other site 703339003034 putative catalytic residues [active] 703339003035 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 703339003036 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 703339003037 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 703339003038 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 703339003039 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 703339003040 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 703339003041 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 703339003042 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 703339003043 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 703339003044 Walker A/P-loop; other site 703339003045 ATP binding site [chemical binding]; other site 703339003046 Q-loop/lid; other site 703339003047 ABC transporter signature motif; other site 703339003048 Walker B; other site 703339003049 D-loop; other site 703339003050 H-loop/switch region; other site 703339003051 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 703339003052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 703339003053 Walker A/P-loop; other site 703339003054 ATP binding site [chemical binding]; other site 703339003055 Q-loop/lid; other site 703339003056 ABC transporter signature motif; other site 703339003057 Walker B; other site 703339003058 D-loop; other site 703339003059 H-loop/switch region; other site 703339003060 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 703339003061 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 703339003062 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 703339003063 putative RNA binding site [nucleotide binding]; other site 703339003064 Methyltransferase domain; Region: Methyltransf_26; pfam13659 703339003065 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 703339003066 dimerization domain swap beta strand [polypeptide binding]; other site 703339003067 regulatory protein interface [polypeptide binding]; other site 703339003068 active site 703339003069 regulatory phosphorylation site [posttranslational modification]; other site 703339003070 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 703339003071 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 703339003072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 703339003073 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 703339003074 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 703339003075 catalytic residues [active] 703339003076 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 703339003077 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 703339003078 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 703339003079 TrkA-N domain; Region: TrkA_N; pfam02254 703339003080 TrkA-C domain; Region: TrkA_C; pfam02080 703339003081 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339003082 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 703339003083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 703339003084 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 703339003085 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 703339003086 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 703339003087 active site 703339003088 catalytic residues [active] 703339003089 metal binding site [ion binding]; metal-binding site 703339003090 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 703339003091 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 703339003092 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 703339003093 TPP-binding site [chemical binding]; other site 703339003094 tetramer interface [polypeptide binding]; other site 703339003095 heterodimer interface [polypeptide binding]; other site 703339003096 phosphorylation loop region [posttranslational modification] 703339003097 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 703339003098 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 703339003099 alpha subunit interface [polypeptide binding]; other site 703339003100 TPP binding site [chemical binding]; other site 703339003101 heterodimer interface [polypeptide binding]; other site 703339003102 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 703339003103 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 703339003104 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 703339003105 E3 interaction surface; other site 703339003106 lipoyl attachment site [posttranslational modification]; other site 703339003107 e3 binding domain; Region: E3_binding; pfam02817 703339003108 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 703339003109 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 703339003110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 703339003111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339003112 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 703339003113 hypothetical protein; Provisional; Region: PRK04387 703339003114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 703339003115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339003116 non-specific DNA binding site [nucleotide binding]; other site 703339003117 salt bridge; other site 703339003118 sequence-specific DNA binding site [nucleotide binding]; other site 703339003119 Cupin domain; Region: Cupin_2; pfam07883 703339003120 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 703339003121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339003122 Walker A/P-loop; other site 703339003123 ATP binding site [chemical binding]; other site 703339003124 Q-loop/lid; other site 703339003125 ABC transporter signature motif; other site 703339003126 Walker B; other site 703339003127 D-loop; other site 703339003128 H-loop/switch region; other site 703339003129 TOBE domain; Region: TOBE_2; pfam08402 703339003130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339003131 putative PBP binding loops; other site 703339003132 dimer interface [polypeptide binding]; other site 703339003133 ABC-ATPase subunit interface; other site 703339003134 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 703339003135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339003136 dimer interface [polypeptide binding]; other site 703339003137 conserved gate region; other site 703339003138 putative PBP binding loops; other site 703339003139 ABC-ATPase subunit interface; other site 703339003140 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 703339003141 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 703339003142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 703339003143 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 703339003144 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 703339003145 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 703339003146 manganese transport protein MntH; Reviewed; Region: PRK00701 703339003147 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 703339003148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 703339003149 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 703339003150 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 703339003151 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 703339003152 active site 703339003153 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 703339003154 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 703339003155 G1 box; other site 703339003156 putative GEF interaction site [polypeptide binding]; other site 703339003157 GTP/Mg2+ binding site [chemical binding]; other site 703339003158 Switch I region; other site 703339003159 G2 box; other site 703339003160 G3 box; other site 703339003161 Switch II region; other site 703339003162 G4 box; other site 703339003163 G5 box; other site 703339003164 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 703339003165 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 703339003166 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 703339003167 hypothetical protein; Provisional; Region: PRK13666 703339003168 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 703339003169 pyruvate carboxylase; Reviewed; Region: PRK12999 703339003170 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 703339003171 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 703339003172 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 703339003173 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 703339003174 active site 703339003175 catalytic residues [active] 703339003176 metal binding site [ion binding]; metal-binding site 703339003177 homodimer binding site [polypeptide binding]; other site 703339003178 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 703339003179 carboxyltransferase (CT) interaction site; other site 703339003180 biotinylation site [posttranslational modification]; other site 703339003181 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 703339003182 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 703339003183 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 703339003184 UbiA prenyltransferase family; Region: UbiA; pfam01040 703339003185 Predicted membrane protein [Function unknown]; Region: COG2322 703339003186 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 703339003187 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 703339003188 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 703339003189 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 703339003190 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 703339003191 putative active site [active] 703339003192 catalytic site [active] 703339003193 putative metal binding site [ion binding]; other site 703339003194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 703339003195 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 703339003196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339003197 S-adenosylmethionine binding site [chemical binding]; other site 703339003198 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 703339003199 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 703339003200 active site 703339003201 (T/H)XGH motif; other site 703339003202 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 703339003203 hypothetical protein; Provisional; Region: PRK13670 703339003204 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 703339003205 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 703339003206 heme uptake protein IsdB; Region: IsdB; TIGR03657 703339003207 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339003208 NEAr Transporter domain; Region: NEAT; smart00725 703339003209 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 703339003210 heme-binding site [chemical binding]; other site 703339003211 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 703339003212 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 703339003213 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 703339003214 heme-binding site [chemical binding]; other site 703339003215 heme uptake protein IsdC; Region: IsdC; TIGR03656 703339003216 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 703339003217 heme-binding site [chemical binding]; other site 703339003218 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 703339003219 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 703339003220 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 703339003221 intersubunit interface [polypeptide binding]; other site 703339003222 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 703339003223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339003224 ABC-ATPase subunit interface; other site 703339003225 dimer interface [polypeptide binding]; other site 703339003226 putative PBP binding regions; other site 703339003227 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 703339003228 active site 703339003229 catalytic site [active] 703339003230 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 703339003231 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 703339003232 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 703339003233 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 703339003234 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 703339003235 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 703339003236 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 703339003237 dimer interface [polypeptide binding]; other site 703339003238 motif 1; other site 703339003239 active site 703339003240 motif 2; other site 703339003241 motif 3; other site 703339003242 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 703339003243 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 703339003244 putative tRNA-binding site [nucleotide binding]; other site 703339003245 B3/4 domain; Region: B3_4; pfam03483 703339003246 tRNA synthetase B5 domain; Region: B5; smart00874 703339003247 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 703339003248 dimer interface [polypeptide binding]; other site 703339003249 motif 1; other site 703339003250 motif 3; other site 703339003251 motif 2; other site 703339003252 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 703339003253 ribonuclease HIII; Provisional; Region: PRK00996 703339003254 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 703339003255 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 703339003256 RNA/DNA hybrid binding site [nucleotide binding]; other site 703339003257 active site 703339003258 Cell division protein ZapA; Region: ZapA; cl01146 703339003259 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 703339003260 Colicin V production protein; Region: Colicin_V; pfam02674 703339003261 hypothetical protein; Provisional; Region: PRK08609 703339003262 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 703339003263 active site 703339003264 primer binding site [nucleotide binding]; other site 703339003265 NTP binding site [chemical binding]; other site 703339003266 metal binding triad [ion binding]; metal-binding site 703339003267 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 703339003268 active site 703339003269 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 703339003270 MutS domain III; Region: MutS_III; pfam05192 703339003271 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 703339003272 Walker A/P-loop; other site 703339003273 ATP binding site [chemical binding]; other site 703339003274 Q-loop/lid; other site 703339003275 ABC transporter signature motif; other site 703339003276 Walker B; other site 703339003277 D-loop; other site 703339003278 H-loop/switch region; other site 703339003279 Smr domain; Region: Smr; pfam01713 703339003280 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 703339003281 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 703339003282 catalytic residues [active] 703339003283 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 703339003284 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 703339003285 GIY-YIG motif/motif A; other site 703339003286 active site 703339003287 catalytic site [active] 703339003288 putative DNA binding site [nucleotide binding]; other site 703339003289 metal binding site [ion binding]; metal-binding site 703339003290 UvrB/uvrC motif; Region: UVR; pfam02151 703339003291 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 703339003292 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 703339003293 putative Iron-sulfur protein interface [polypeptide binding]; other site 703339003294 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 703339003295 proximal heme binding site [chemical binding]; other site 703339003296 distal heme binding site [chemical binding]; other site 703339003297 putative dimer interface [polypeptide binding]; other site 703339003298 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 703339003299 L-aspartate oxidase; Provisional; Region: PRK06175 703339003300 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 703339003301 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 703339003302 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 703339003303 glutamate racemase; Provisional; Region: PRK00865 703339003304 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 703339003305 active site 703339003306 dimerization interface [polypeptide binding]; other site 703339003307 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 703339003308 active site 703339003309 metal binding site [ion binding]; metal-binding site 703339003310 homotetramer interface [polypeptide binding]; other site 703339003311 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 703339003312 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 703339003313 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 703339003314 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 703339003315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 703339003316 Transposase; Region: DDE_Tnp_ISL3; pfam01610 703339003317 beta-channel forming cytolysin; Region: hlyII; TIGR01002 703339003318 superantigen-like protein; Reviewed; Region: PRK13350 703339003319 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339003320 superantigen-like protein; Reviewed; Region: PRK13349 703339003321 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339003322 superantigen-like protein; Reviewed; Region: PRK13043 703339003323 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339003324 ornithine carbamoyltransferase; Provisional; Region: PRK04284 703339003325 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 703339003326 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 703339003327 carbamate kinase; Reviewed; Region: PRK12686 703339003328 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 703339003329 putative substrate binding site [chemical binding]; other site 703339003330 nucleotide binding site [chemical binding]; other site 703339003331 nucleotide binding site [chemical binding]; other site 703339003332 homodimer interface [polypeptide binding]; other site 703339003333 Predicted membrane protein [Function unknown]; Region: COG1288 703339003334 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 703339003335 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 703339003336 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 703339003337 gating phenylalanine in ion channel; other site 703339003338 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 703339003339 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 703339003340 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 703339003341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339003342 motif II; other site 703339003343 hypothetical protein; Provisional; Region: PRK13688 703339003344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 703339003345 Coenzyme A binding pocket [chemical binding]; other site 703339003346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 703339003347 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 703339003348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 703339003349 MraZ protein; Region: MraZ; pfam02381 703339003350 MraZ protein; Region: MraZ; pfam02381 703339003351 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 703339003352 MraW methylase family; Region: Methyltransf_5; pfam01795 703339003353 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 703339003354 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 703339003355 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 703339003356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 703339003357 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 703339003358 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 703339003359 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 703339003360 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 703339003361 Mg++ binding site [ion binding]; other site 703339003362 putative catalytic motif [active] 703339003363 putative substrate binding site [chemical binding]; other site 703339003364 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 703339003365 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 703339003366 NAD binding site [chemical binding]; other site 703339003367 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 703339003368 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 703339003369 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 703339003370 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 703339003371 Cell division protein FtsQ; Region: FtsQ; pfam03799 703339003372 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 703339003373 Cell division protein FtsA; Region: FtsA; smart00842 703339003374 Cell division protein FtsA; Region: FtsA; pfam14450 703339003375 cell division protein FtsZ; Validated; Region: PRK09330 703339003376 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 703339003377 nucleotide binding site [chemical binding]; other site 703339003378 SulA interaction site; other site 703339003379 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 703339003380 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 703339003381 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 703339003382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 703339003383 catalytic residue [active] 703339003384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 703339003385 YGGT family; Region: YGGT; pfam02325 703339003386 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 703339003387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339003388 RNA binding surface [nucleotide binding]; other site 703339003389 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 703339003390 DivIVA domain; Region: DivI1A_domain; TIGR03544 703339003391 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 703339003392 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 703339003393 HIGH motif; other site 703339003394 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 703339003395 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 703339003396 active site 703339003397 KMSKS motif; other site 703339003398 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 703339003399 tRNA binding surface [nucleotide binding]; other site 703339003400 anticodon binding site; other site 703339003401 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 703339003402 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 703339003403 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 703339003404 active site 703339003405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 703339003406 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 703339003407 lipoprotein signal peptidase; Provisional; Region: PRK14787 703339003408 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 703339003409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339003410 RNA binding surface [nucleotide binding]; other site 703339003411 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 703339003412 active site 703339003413 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 703339003414 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 703339003415 uracil transporter; Provisional; Region: PRK10720 703339003416 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 703339003417 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 703339003418 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 703339003419 dihydroorotase; Validated; Region: pyrC; PRK09357 703339003420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 703339003421 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 703339003422 active site 703339003423 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 703339003424 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 703339003425 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 703339003426 catalytic site [active] 703339003427 subunit interface [polypeptide binding]; other site 703339003428 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 703339003429 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 703339003430 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 703339003431 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 703339003432 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 703339003433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 703339003434 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 703339003435 IMP binding site; other site 703339003436 dimer interface [polypeptide binding]; other site 703339003437 interdomain contacts; other site 703339003438 partial ornithine binding site; other site 703339003439 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 703339003440 active site 703339003441 dimer interface [polypeptide binding]; other site 703339003442 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339003443 active site 703339003444 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 703339003445 dimer interface [polypeptide binding]; other site 703339003446 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 703339003447 Domain of unknown function (DUF814); Region: DUF814; pfam05670 703339003448 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 703339003449 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 703339003450 catalytic site [active] 703339003451 G-X2-G-X-G-K; other site 703339003452 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 703339003453 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 703339003454 Flavoprotein; Region: Flavoprotein; pfam02441 703339003455 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 703339003456 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 703339003457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339003458 ATP binding site [chemical binding]; other site 703339003459 putative Mg++ binding site [ion binding]; other site 703339003460 helicase superfamily c-terminal domain; Region: HELICc; smart00490 703339003461 nucleotide binding region [chemical binding]; other site 703339003462 ATP-binding site [chemical binding]; other site 703339003463 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 703339003464 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 703339003465 active site 703339003466 catalytic residues [active] 703339003467 metal binding site [ion binding]; metal-binding site 703339003468 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 703339003469 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 703339003470 putative active site [active] 703339003471 substrate binding site [chemical binding]; other site 703339003472 putative cosubstrate binding site; other site 703339003473 catalytic site [active] 703339003474 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 703339003475 substrate binding site [chemical binding]; other site 703339003476 16S rRNA methyltransferase B; Provisional; Region: PRK14902 703339003477 NusB family; Region: NusB; pfam01029 703339003478 putative RNA binding site [nucleotide binding]; other site 703339003479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339003480 S-adenosylmethionine binding site [chemical binding]; other site 703339003481 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 703339003482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339003483 FeS/SAM binding site; other site 703339003484 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 703339003485 Protein phosphatase 2C; Region: PP2C; pfam00481 703339003486 active site 703339003487 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 703339003488 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 703339003489 active site 703339003490 ATP binding site [chemical binding]; other site 703339003491 substrate binding site [chemical binding]; other site 703339003492 activation loop (A-loop); other site 703339003493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 703339003494 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 703339003495 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 703339003496 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 703339003497 Predicted GTPases [General function prediction only]; Region: COG1162 703339003498 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 703339003499 RNA binding site [nucleotide binding]; other site 703339003500 homodimer interface [polypeptide binding]; other site 703339003501 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 703339003502 GTPase/Zn-binding domain interface [polypeptide binding]; other site 703339003503 GTP/Mg2+ binding site [chemical binding]; other site 703339003504 G4 box; other site 703339003505 G5 box; other site 703339003506 G1 box; other site 703339003507 Switch I region; other site 703339003508 G2 box; other site 703339003509 G3 box; other site 703339003510 Switch II region; other site 703339003511 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 703339003512 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 703339003513 substrate binding site [chemical binding]; other site 703339003514 hexamer interface [polypeptide binding]; other site 703339003515 metal binding site [ion binding]; metal-binding site 703339003516 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 703339003517 Thiamine pyrophosphokinase; Region: TPK; cd07995 703339003518 active site 703339003519 dimerization interface [polypeptide binding]; other site 703339003520 thiamine binding site [chemical binding]; other site 703339003521 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 703339003522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 703339003523 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 703339003524 DAK2 domain; Region: Dak2; pfam02734 703339003525 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 703339003526 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 703339003527 generic binding surface II; other site 703339003528 ssDNA binding site; other site 703339003529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339003530 ATP binding site [chemical binding]; other site 703339003531 putative Mg++ binding site [ion binding]; other site 703339003532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339003533 nucleotide binding region [chemical binding]; other site 703339003534 ATP-binding site [chemical binding]; other site 703339003535 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 703339003536 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 703339003537 active site 2 [active] 703339003538 active site 1 [active] 703339003539 putative phosphate acyltransferase; Provisional; Region: PRK05331 703339003540 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 703339003541 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 703339003542 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 703339003543 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 703339003544 NAD(P) binding site [chemical binding]; other site 703339003545 homotetramer interface [polypeptide binding]; other site 703339003546 homodimer interface [polypeptide binding]; other site 703339003547 active site 703339003548 acyl carrier protein; Provisional; Region: acpP; PRK00982 703339003549 ribonuclease III; Reviewed; Region: rnc; PRK00102 703339003550 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 703339003551 dimerization interface [polypeptide binding]; other site 703339003552 active site 703339003553 metal binding site [ion binding]; metal-binding site 703339003554 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 703339003555 dsRNA binding site [nucleotide binding]; other site 703339003556 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 703339003557 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 703339003558 Walker A/P-loop; other site 703339003559 ATP binding site [chemical binding]; other site 703339003560 Q-loop/lid; other site 703339003561 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 703339003562 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 703339003563 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 703339003564 ABC transporter signature motif; other site 703339003565 Walker B; other site 703339003566 D-loop; other site 703339003567 H-loop/switch region; other site 703339003568 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 703339003569 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 703339003570 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 703339003571 P loop; other site 703339003572 GTP binding site [chemical binding]; other site 703339003573 putative DNA-binding protein; Validated; Region: PRK00118 703339003574 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 703339003575 signal recognition particle protein; Provisional; Region: PRK10867 703339003576 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 703339003577 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 703339003578 P loop; other site 703339003579 GTP binding site [chemical binding]; other site 703339003580 Signal peptide binding domain; Region: SRP_SPB; pfam02978 703339003581 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 703339003582 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 703339003583 RimM N-terminal domain; Region: RimM; pfam01782 703339003584 PRC-barrel domain; Region: PRC; pfam05239 703339003585 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 703339003586 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 703339003587 Predicted membrane protein [Function unknown]; Region: COG4485 703339003588 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 703339003589 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 703339003590 GTP/Mg2+ binding site [chemical binding]; other site 703339003591 G4 box; other site 703339003592 G5 box; other site 703339003593 G1 box; other site 703339003594 Switch I region; other site 703339003595 G2 box; other site 703339003596 G3 box; other site 703339003597 Switch II region; other site 703339003598 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 703339003599 RNA/DNA hybrid binding site [nucleotide binding]; other site 703339003600 active site 703339003601 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 703339003602 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 703339003603 CoA-ligase; Region: Ligase_CoA; pfam00549 703339003604 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 703339003605 CoA binding domain; Region: CoA_binding; pfam02629 703339003606 CoA-ligase; Region: Ligase_CoA; pfam00549 703339003607 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 703339003608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339003609 CHAP domain; Region: CHAP; pfam05257 703339003610 FemAB family; Region: FemAB; pfam02388 703339003611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 703339003612 DNA protecting protein DprA; Region: dprA; TIGR00732 703339003613 DNA topoisomerase I; Validated; Region: PRK05582 703339003614 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 703339003615 active site 703339003616 interdomain interaction site; other site 703339003617 putative metal-binding site [ion binding]; other site 703339003618 nucleotide binding site [chemical binding]; other site 703339003619 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 703339003620 domain I; other site 703339003621 DNA binding groove [nucleotide binding] 703339003622 phosphate binding site [ion binding]; other site 703339003623 domain II; other site 703339003624 domain III; other site 703339003625 nucleotide binding site [chemical binding]; other site 703339003626 catalytic site [active] 703339003627 domain IV; other site 703339003628 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 703339003629 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 703339003630 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 703339003631 Glucose inhibited division protein A; Region: GIDA; pfam01134 703339003632 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 703339003633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 703339003634 active site 703339003635 DNA binding site [nucleotide binding] 703339003636 Int/Topo IB signature motif; other site 703339003637 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 703339003638 active site 703339003639 HslU subunit interaction site [polypeptide binding]; other site 703339003640 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 703339003641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339003642 Walker A motif; other site 703339003643 ATP binding site [chemical binding]; other site 703339003644 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 703339003645 Walker B motif; other site 703339003646 arginine finger; other site 703339003647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 703339003648 transcriptional repressor CodY; Validated; Region: PRK04158 703339003649 CodY GAF-like domain; Region: CodY; pfam06018 703339003650 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 703339003651 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 703339003652 rRNA interaction site [nucleotide binding]; other site 703339003653 S8 interaction site; other site 703339003654 putative laminin-1 binding site; other site 703339003655 elongation factor Ts; Provisional; Region: tsf; PRK09377 703339003656 UBA/TS-N domain; Region: UBA; pfam00627 703339003657 Elongation factor TS; Region: EF_TS; pfam00889 703339003658 Elongation factor TS; Region: EF_TS; pfam00889 703339003659 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 703339003660 putative nucleotide binding site [chemical binding]; other site 703339003661 uridine monophosphate binding site [chemical binding]; other site 703339003662 homohexameric interface [polypeptide binding]; other site 703339003663 ribosome recycling factor; Reviewed; Region: frr; PRK00083 703339003664 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 703339003665 hinge region; other site 703339003666 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 703339003667 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 703339003668 catalytic residue [active] 703339003669 putative FPP diphosphate binding site; other site 703339003670 putative FPP binding hydrophobic cleft; other site 703339003671 dimer interface [polypeptide binding]; other site 703339003672 putative IPP diphosphate binding site; other site 703339003673 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 703339003674 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 703339003675 RIP metalloprotease RseP; Region: TIGR00054 703339003676 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 703339003677 active site 703339003678 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 703339003679 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 703339003680 protein binding site [polypeptide binding]; other site 703339003681 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 703339003682 putative substrate binding region [chemical binding]; other site 703339003683 prolyl-tRNA synthetase; Provisional; Region: PRK09194 703339003684 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 703339003685 dimer interface [polypeptide binding]; other site 703339003686 motif 1; other site 703339003687 active site 703339003688 motif 2; other site 703339003689 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 703339003690 putative deacylase active site [active] 703339003691 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 703339003692 active site 703339003693 motif 3; other site 703339003694 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 703339003695 anticodon binding site; other site 703339003696 DNA polymerase III PolC; Validated; Region: polC; PRK00448 703339003697 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 703339003698 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 703339003699 generic binding surface II; other site 703339003700 generic binding surface I; other site 703339003701 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 703339003702 active site 703339003703 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 703339003704 active site 703339003705 catalytic site [active] 703339003706 substrate binding site [chemical binding]; other site 703339003707 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 703339003708 ribosome maturation protein RimP; Reviewed; Region: PRK00092 703339003709 Sm and related proteins; Region: Sm_like; cl00259 703339003710 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 703339003711 putative oligomer interface [polypeptide binding]; other site 703339003712 putative RNA binding site [nucleotide binding]; other site 703339003713 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 703339003714 NusA N-terminal domain; Region: NusA_N; pfam08529 703339003715 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 703339003716 RNA binding site [nucleotide binding]; other site 703339003717 homodimer interface [polypeptide binding]; other site 703339003718 NusA-like KH domain; Region: KH_5; pfam13184 703339003719 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 703339003720 G-X-X-G motif; other site 703339003721 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 703339003722 putative RNA binding cleft [nucleotide binding]; other site 703339003723 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 703339003724 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 703339003725 translation initiation factor IF-2; Region: IF-2; TIGR00487 703339003726 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 703339003727 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 703339003728 G1 box; other site 703339003729 putative GEF interaction site [polypeptide binding]; other site 703339003730 GTP/Mg2+ binding site [chemical binding]; other site 703339003731 Switch I region; other site 703339003732 G2 box; other site 703339003733 G3 box; other site 703339003734 Switch II region; other site 703339003735 G4 box; other site 703339003736 G5 box; other site 703339003737 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 703339003738 Translation-initiation factor 2; Region: IF-2; pfam11987 703339003739 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 703339003740 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 703339003741 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 703339003742 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 703339003743 RNA binding site [nucleotide binding]; other site 703339003744 active site 703339003745 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 703339003746 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 703339003747 active site 703339003748 Riboflavin kinase; Region: Flavokinase; smart00904 703339003749 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 703339003750 16S/18S rRNA binding site [nucleotide binding]; other site 703339003751 S13e-L30e interaction site [polypeptide binding]; other site 703339003752 25S rRNA binding site [nucleotide binding]; other site 703339003753 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 703339003754 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 703339003755 RNase E interface [polypeptide binding]; other site 703339003756 trimer interface [polypeptide binding]; other site 703339003757 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 703339003758 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 703339003759 RNase E interface [polypeptide binding]; other site 703339003760 trimer interface [polypeptide binding]; other site 703339003761 active site 703339003762 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 703339003763 putative nucleic acid binding region [nucleotide binding]; other site 703339003764 G-X-X-G motif; other site 703339003765 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 703339003766 RNA binding site [nucleotide binding]; other site 703339003767 domain interface; other site 703339003768 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 703339003769 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 703339003770 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 703339003771 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 703339003772 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 703339003773 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 703339003774 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 703339003775 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 703339003776 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 703339003777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 703339003778 DNA-binding site [nucleotide binding]; DNA binding site 703339003779 UTRA domain; Region: UTRA; pfam07702 703339003780 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 703339003781 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 703339003782 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 703339003783 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 703339003784 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 703339003785 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 703339003786 classical (c) SDRs; Region: SDR_c; cd05233 703339003787 NAD(P) binding site [chemical binding]; other site 703339003788 active site 703339003789 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 703339003790 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 703339003791 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 703339003792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339003793 non-specific DNA binding site [nucleotide binding]; other site 703339003794 salt bridge; other site 703339003795 sequence-specific DNA binding site [nucleotide binding]; other site 703339003796 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 703339003797 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 703339003798 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 703339003799 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 703339003800 putative MPT binding site; other site 703339003801 recombinase A; Provisional; Region: recA; PRK09354 703339003802 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 703339003803 hexamer interface [polypeptide binding]; other site 703339003804 Walker A motif; other site 703339003805 ATP binding site [chemical binding]; other site 703339003806 Walker B motif; other site 703339003807 phosphodiesterase; Provisional; Region: PRK12704 703339003808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 703339003809 Zn2+ binding site [ion binding]; other site 703339003810 Mg2+ binding site [ion binding]; other site 703339003811 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 703339003812 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 703339003813 putative active site [active] 703339003814 metal binding site [ion binding]; metal-binding site 703339003815 homodimer binding site [polypeptide binding]; other site 703339003816 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 703339003817 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 703339003818 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 703339003819 dimer interface [polypeptide binding]; other site 703339003820 PYR/PP interface [polypeptide binding]; other site 703339003821 TPP binding site [chemical binding]; other site 703339003822 substrate binding site [chemical binding]; other site 703339003823 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 703339003824 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 703339003825 TPP-binding site [chemical binding]; other site 703339003826 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 703339003827 Uncharacterized conserved protein [Function unknown]; Region: COG0011 703339003828 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 703339003829 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 703339003830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339003831 FeS/SAM binding site; other site 703339003832 TRAM domain; Region: TRAM; pfam01938 703339003833 Predicted membrane protein [Function unknown]; Region: COG4550 703339003834 Predicted membrane protein [Function unknown]; Region: COG4732 703339003835 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 703339003836 MutS domain I; Region: MutS_I; pfam01624 703339003837 MutS domain II; Region: MutS_II; pfam05188 703339003838 MutS domain III; Region: MutS_III; pfam05192 703339003839 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 703339003840 Walker A/P-loop; other site 703339003841 ATP binding site [chemical binding]; other site 703339003842 Q-loop/lid; other site 703339003843 ABC transporter signature motif; other site 703339003844 Walker B; other site 703339003845 D-loop; other site 703339003846 H-loop/switch region; other site 703339003847 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 703339003848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339003849 ATP binding site [chemical binding]; other site 703339003850 Mg2+ binding site [ion binding]; other site 703339003851 G-X-G motif; other site 703339003852 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 703339003853 ATP binding site [chemical binding]; other site 703339003854 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 703339003855 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 703339003856 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 703339003857 amphipathic channel; other site 703339003858 Asn-Pro-Ala signature motifs; other site 703339003859 glycerol kinase; Provisional; Region: glpK; PRK00047 703339003860 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 703339003861 N- and C-terminal domain interface [polypeptide binding]; other site 703339003862 active site 703339003863 MgATP binding site [chemical binding]; other site 703339003864 catalytic site [active] 703339003865 metal binding site [ion binding]; metal-binding site 703339003866 glycerol binding site [chemical binding]; other site 703339003867 homotetramer interface [polypeptide binding]; other site 703339003868 homodimer interface [polypeptide binding]; other site 703339003869 FBP binding site [chemical binding]; other site 703339003870 protein IIAGlc interface [polypeptide binding]; other site 703339003871 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 703339003872 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 703339003873 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 703339003874 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 703339003875 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 703339003876 bacterial Hfq-like; Region: Hfq; cd01716 703339003877 hexamer interface [polypeptide binding]; other site 703339003878 Sm1 motif; other site 703339003879 RNA binding site [nucleotide binding]; other site 703339003880 Sm2 motif; other site 703339003881 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 703339003882 catalytic residues [active] 703339003883 dimer interface [polypeptide binding]; other site 703339003884 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 703339003885 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 703339003886 HflX GTPase family; Region: HflX; cd01878 703339003887 G1 box; other site 703339003888 GTP/Mg2+ binding site [chemical binding]; other site 703339003889 Switch I region; other site 703339003890 G2 box; other site 703339003891 G3 box; other site 703339003892 Switch II region; other site 703339003893 G4 box; other site 703339003894 G5 box; other site 703339003895 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 703339003896 Aluminium resistance protein; Region: Alum_res; pfam06838 703339003897 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 703339003898 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 703339003899 DNA binding residues [nucleotide binding] 703339003900 putative dimer interface [polypeptide binding]; other site 703339003901 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 703339003902 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 703339003903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 703339003904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 703339003905 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 703339003906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 703339003907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339003908 catalytic residue [active] 703339003909 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 703339003910 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 703339003911 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 703339003912 putative active site [active] 703339003913 catalytic site [active] 703339003914 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 703339003915 putative active site [active] 703339003916 catalytic site [active] 703339003917 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 703339003918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339003919 Walker A/P-loop; other site 703339003920 ATP binding site [chemical binding]; other site 703339003921 Q-loop/lid; other site 703339003922 ABC transporter signature motif; other site 703339003923 Walker B; other site 703339003924 D-loop; other site 703339003925 H-loop/switch region; other site 703339003926 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 703339003927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 703339003928 Histidine kinase; Region: HisKA_3; pfam07730 703339003929 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 703339003930 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 703339003931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339003932 active site 703339003933 phosphorylation site [posttranslational modification] 703339003934 intermolecular recognition site; other site 703339003935 dimerization interface [polypeptide binding]; other site 703339003936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 703339003937 DNA binding residues [nucleotide binding] 703339003938 dimerization interface [polypeptide binding]; other site 703339003939 Staphylococcal nuclease homologues; Region: SNc; smart00318 703339003940 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 703339003941 Catalytic site; other site 703339003942 AAA domain; Region: AAA_11; pfam13086 703339003943 aspartate kinase; Reviewed; Region: PRK09034 703339003944 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 703339003945 putative catalytic residues [active] 703339003946 putative nucleotide binding site [chemical binding]; other site 703339003947 putative aspartate binding site [chemical binding]; other site 703339003948 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 703339003949 allosteric regulatory residue; other site 703339003950 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 703339003951 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 703339003952 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 703339003953 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 703339003954 threonine synthase; Reviewed; Region: PRK06721 703339003955 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 703339003956 homodimer interface [polypeptide binding]; other site 703339003957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339003958 catalytic residue [active] 703339003959 homoserine kinase; Provisional; Region: PRK01212 703339003960 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 703339003961 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 703339003962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339003963 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 703339003964 active site 703339003965 motif I; other site 703339003966 motif II; other site 703339003967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 703339003968 lysine transporter; Provisional; Region: PRK10836 703339003969 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 703339003970 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 703339003971 tetramer interface [polypeptide binding]; other site 703339003972 heme binding pocket [chemical binding]; other site 703339003973 NADPH binding site [chemical binding]; other site 703339003974 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 703339003975 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 703339003976 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 703339003977 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 703339003978 active site 703339003979 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 703339003980 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 703339003981 LexA repressor; Validated; Region: PRK00215 703339003982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 703339003983 putative DNA binding site [nucleotide binding]; other site 703339003984 putative Zn2+ binding site [ion binding]; other site 703339003985 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 703339003986 Catalytic site [active] 703339003987 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 703339003988 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 703339003989 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 703339003990 TPP-binding site [chemical binding]; other site 703339003991 dimer interface [polypeptide binding]; other site 703339003992 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 703339003993 PYR/PP interface [polypeptide binding]; other site 703339003994 dimer interface [polypeptide binding]; other site 703339003995 TPP binding site [chemical binding]; other site 703339003996 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 703339003997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 703339003998 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 703339003999 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 703339004000 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 703339004001 active site 703339004002 metal binding site [ion binding]; metal-binding site 703339004003 DNA binding site [nucleotide binding] 703339004004 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 703339004005 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 703339004006 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 703339004007 Walker A/P-loop; other site 703339004008 ATP binding site [chemical binding]; other site 703339004009 Q-loop/lid; other site 703339004010 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 703339004011 ABC transporter signature motif; other site 703339004012 Walker B; other site 703339004013 D-loop; other site 703339004014 H-loop/switch region; other site 703339004015 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 703339004016 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 703339004017 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 703339004018 aconitate hydratase; Validated; Region: PRK09277 703339004019 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 703339004020 substrate binding site [chemical binding]; other site 703339004021 ligand binding site [chemical binding]; other site 703339004022 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 703339004023 substrate binding site [chemical binding]; other site 703339004024 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 703339004025 active site 703339004026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 703339004027 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 703339004028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 703339004029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339004030 ATP binding site [chemical binding]; other site 703339004031 Mg2+ binding site [ion binding]; other site 703339004032 G-X-G motif; other site 703339004033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 703339004034 anchoring element; other site 703339004035 dimer interface [polypeptide binding]; other site 703339004036 ATP binding site [chemical binding]; other site 703339004037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 703339004038 active site 703339004039 putative metal-binding site [ion binding]; other site 703339004040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 703339004041 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 703339004042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 703339004043 CAP-like domain; other site 703339004044 active site 703339004045 primary dimer interface [polypeptide binding]; other site 703339004046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 703339004047 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 703339004048 amino acid carrier protein; Region: agcS; TIGR00835 703339004049 CAT RNA binding domain; Region: CAT_RBD; smart01061 703339004050 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 703339004051 PRD domain; Region: PRD; pfam00874 703339004052 PRD domain; Region: PRD; pfam00874 703339004053 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 703339004054 Domain of unknown function DUF20; Region: UPF0118; pfam01594 703339004055 Predicted integral membrane protein [Function unknown]; Region: COG0392 703339004056 Uncharacterized conserved protein [Function unknown]; Region: COG2898 703339004057 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 703339004058 methionine sulfoxide reductase A; Provisional; Region: PRK14054 703339004059 Transcriptional regulator [Transcription]; Region: LytR; COG1316 703339004060 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 703339004061 active site 1 [active] 703339004062 dimer interface [polypeptide binding]; other site 703339004063 hexamer interface [polypeptide binding]; other site 703339004064 active site 2 [active] 703339004065 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 703339004066 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 703339004067 active site 703339004068 DNA binding site [nucleotide binding] 703339004069 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 703339004070 prephenate dehydrogenase; Validated; Region: PRK06545 703339004071 prephenate dehydrogenase; Validated; Region: PRK08507 703339004072 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 703339004073 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 703339004074 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 703339004075 putative oligomer interface [polypeptide binding]; other site 703339004076 putative active site [active] 703339004077 metal binding site [ion binding]; metal-binding site 703339004078 anthranilate synthase component I; Provisional; Region: PRK13567 703339004079 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 703339004080 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 703339004081 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 703339004082 Glutamine amidotransferase class-I; Region: GATase; pfam00117 703339004083 glutamine binding [chemical binding]; other site 703339004084 catalytic triad [active] 703339004085 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 703339004086 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 703339004087 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 703339004088 active site 703339004089 ribulose/triose binding site [chemical binding]; other site 703339004090 phosphate binding site [ion binding]; other site 703339004091 substrate (anthranilate) binding pocket [chemical binding]; other site 703339004092 product (indole) binding pocket [chemical binding]; other site 703339004093 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 703339004094 active site 703339004095 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 703339004096 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 703339004097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339004098 catalytic residue [active] 703339004099 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 703339004100 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 703339004101 substrate binding site [chemical binding]; other site 703339004102 active site 703339004103 catalytic residues [active] 703339004104 heterodimer interface [polypeptide binding]; other site 703339004105 FemAB family; Region: FemAB; pfam02388 703339004106 FlxA-like protein; Region: FlxA; pfam14282 703339004107 FemAB family; Region: FemAB; pfam02388 703339004108 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 703339004109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339004110 active site 703339004111 motif I; other site 703339004112 motif II; other site 703339004113 SWIM zinc finger; Region: SWIM; pfam04434 703339004114 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 703339004115 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339004116 Walker A/P-loop; other site 703339004117 ATP binding site [chemical binding]; other site 703339004118 Q-loop/lid; other site 703339004119 ABC transporter signature motif; other site 703339004120 Walker B; other site 703339004121 D-loop; other site 703339004122 H-loop/switch region; other site 703339004123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339004124 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 703339004125 Walker A/P-loop; other site 703339004126 ATP binding site [chemical binding]; other site 703339004127 Q-loop/lid; other site 703339004128 ABC transporter signature motif; other site 703339004129 Walker B; other site 703339004130 D-loop; other site 703339004131 H-loop/switch region; other site 703339004132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 703339004133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339004134 dimer interface [polypeptide binding]; other site 703339004135 conserved gate region; other site 703339004136 putative PBP binding loops; other site 703339004137 ABC-ATPase subunit interface; other site 703339004138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 703339004139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339004140 dimer interface [polypeptide binding]; other site 703339004141 conserved gate region; other site 703339004142 putative PBP binding loops; other site 703339004143 ABC-ATPase subunit interface; other site 703339004144 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 703339004145 oligoendopeptidase F; Region: pepF; TIGR00181 703339004146 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 703339004147 active site 703339004148 Zn binding site [ion binding]; other site 703339004149 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 703339004150 PhoU domain; Region: PhoU; pfam01895 703339004151 PhoU domain; Region: PhoU; pfam01895 703339004152 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 703339004153 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 703339004154 Walker A/P-loop; other site 703339004155 ATP binding site [chemical binding]; other site 703339004156 Q-loop/lid; other site 703339004157 ABC transporter signature motif; other site 703339004158 Walker B; other site 703339004159 D-loop; other site 703339004160 H-loop/switch region; other site 703339004161 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 703339004162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339004163 dimer interface [polypeptide binding]; other site 703339004164 conserved gate region; other site 703339004165 putative PBP binding loops; other site 703339004166 ABC-ATPase subunit interface; other site 703339004167 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 703339004168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339004169 dimer interface [polypeptide binding]; other site 703339004170 conserved gate region; other site 703339004171 ABC-ATPase subunit interface; other site 703339004172 phosphate binding protein; Region: ptsS_2; TIGR02136 703339004173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 703339004174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 703339004175 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 703339004176 S1 domain; Region: S1_2; pfam13509 703339004177 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 703339004178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339004179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339004180 ABC transporter; Region: ABC_tran_2; pfam12848 703339004181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339004182 aspartate kinase; Reviewed; Region: PRK06635 703339004183 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 703339004184 putative nucleotide binding site [chemical binding]; other site 703339004185 putative catalytic residues [active] 703339004186 putative Mg ion binding site [ion binding]; other site 703339004187 putative aspartate binding site [chemical binding]; other site 703339004188 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 703339004189 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 703339004190 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 703339004191 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 703339004192 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 703339004193 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 703339004194 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 703339004195 dimer interface [polypeptide binding]; other site 703339004196 active site 703339004197 catalytic residue [active] 703339004198 dihydrodipicolinate reductase; Provisional; Region: PRK00048 703339004199 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 703339004200 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 703339004201 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 703339004202 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 703339004203 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 703339004204 active site 703339004205 trimer interface [polypeptide binding]; other site 703339004206 substrate binding site [chemical binding]; other site 703339004207 CoA binding site [chemical binding]; other site 703339004208 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 703339004209 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 703339004210 metal binding site [ion binding]; metal-binding site 703339004211 dimer interface [polypeptide binding]; other site 703339004212 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 703339004213 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 703339004214 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 703339004215 catalytic residue [active] 703339004216 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 703339004217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 703339004218 active site 703339004219 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 703339004220 substrate binding site [chemical binding]; other site 703339004221 catalytic residues [active] 703339004222 dimer interface [polypeptide binding]; other site 703339004223 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 703339004224 DNA-binding site [nucleotide binding]; DNA binding site 703339004225 RNA-binding motif; other site 703339004226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 703339004227 acylphosphatase; Provisional; Region: PRK14431 703339004228 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 703339004229 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 703339004230 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 703339004231 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 703339004232 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 703339004233 metal ion-dependent adhesion site (MIDAS); other site 703339004234 MoxR-like ATPases [General function prediction only]; Region: COG0714 703339004235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339004236 Walker A motif; other site 703339004237 ATP binding site [chemical binding]; other site 703339004238 Walker B motif; other site 703339004239 arginine finger; other site 703339004240 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 703339004241 active site 703339004242 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 703339004243 active site 703339004244 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 703339004245 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 703339004246 E3 interaction surface; other site 703339004247 lipoyl attachment site [posttranslational modification]; other site 703339004248 e3 binding domain; Region: E3_binding; pfam02817 703339004249 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 703339004250 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 703339004251 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 703339004252 TPP-binding site [chemical binding]; other site 703339004253 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 703339004254 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 703339004255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 703339004256 HAMP domain; Region: HAMP; pfam00672 703339004257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339004258 dimer interface [polypeptide binding]; other site 703339004259 phosphorylation site [posttranslational modification] 703339004260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339004261 ATP binding site [chemical binding]; other site 703339004262 Mg2+ binding site [ion binding]; other site 703339004263 G-X-G motif; other site 703339004264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339004265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339004266 active site 703339004267 phosphorylation site [posttranslational modification] 703339004268 intermolecular recognition site; other site 703339004269 dimerization interface [polypeptide binding]; other site 703339004270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339004271 DNA binding site [nucleotide binding] 703339004272 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 703339004273 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 703339004274 active site 703339004275 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 703339004276 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 703339004277 active site 703339004278 homodimer interface [polypeptide binding]; other site 703339004279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339004280 Coenzyme A binding pocket [chemical binding]; other site 703339004281 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 703339004282 C-terminal peptidase (prc); Region: prc; TIGR00225 703339004283 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 703339004284 protein binding site [polypeptide binding]; other site 703339004285 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 703339004286 Catalytic dyad [active] 703339004287 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 703339004288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 703339004289 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 703339004290 HPr interaction site; other site 703339004291 glycerol kinase (GK) interaction site [polypeptide binding]; other site 703339004292 active site 703339004293 phosphorylation site [posttranslational modification] 703339004294 methionine sulfoxide reductase B; Provisional; Region: PRK00222 703339004295 SelR domain; Region: SelR; pfam01641 703339004296 methionine sulfoxide reductase A; Provisional; Region: PRK13014 703339004297 EDD domain protein, DegV family; Region: DegV; TIGR00762 703339004298 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 703339004299 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 703339004300 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 703339004301 folate binding site [chemical binding]; other site 703339004302 NADP+ binding site [chemical binding]; other site 703339004303 thymidylate synthase; Region: thym_sym; TIGR03284 703339004304 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 703339004305 dimerization interface [polypeptide binding]; other site 703339004306 active site 703339004307 Disulphide isomerase; Region: Disulph_isomer; pfam06491 703339004308 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 703339004309 Virulence factor; Region: Virulence_fact; pfam13769 703339004310 HEAT repeats; Region: HEAT_2; pfam13646 703339004311 HEAT repeat; Region: HEAT; pfam02985 703339004312 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 703339004313 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 703339004314 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 703339004315 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 703339004316 RNA/DNA hybrid binding site [nucleotide binding]; other site 703339004317 active site 703339004318 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339004319 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339004320 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339004321 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339004322 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 703339004323 GA module; Region: GA; smart00844 703339004324 GA module; Region: GA; smart00844 703339004325 GA module; Region: GA; smart00844 703339004326 GA module; Region: GA; smart00844 703339004327 GA module; Region: GA; smart00844 703339004328 GA module; Region: GA; smart00844 703339004329 GA module; Region: GA; smart00844 703339004330 GA module; Region: GA; smart00844 703339004331 GA module; Region: GA; smart00844 703339004332 GA module; Region: GA; smart00844 703339004333 GA module; Region: GA; smart00844 703339004334 GA module; Region: GA; smart00844 703339004335 GA module; Region: GA; smart00844 703339004336 GA module; Region: GA; smart00844 703339004337 GA module; Region: GA; smart00844 703339004338 GA module; Region: GA; smart00844 703339004339 GA module; Region: GA; smart00844 703339004340 GA module; Region: GA; smart00844 703339004341 GA module; Region: GA; smart00844 703339004342 GA module; Region: GA; smart00844 703339004343 GA module; Region: GA; smart00844 703339004344 GA module; Region: GA; smart00844 703339004345 GA module; Region: GA; smart00844 703339004346 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 703339004347 GA module; Region: GA; smart00844 703339004348 GA module; Region: GA; smart00844 703339004349 GA module; Region: GA; pfam01468 703339004350 GA module; Region: GA; smart00844 703339004351 GA module; Region: GA; smart00844 703339004352 GA module; Region: GA; smart00844 703339004353 GA module; Region: GA; smart00844 703339004354 GA module; Region: GA; pfam01468 703339004355 GA module; Region: GA; smart00844 703339004356 GA module; Region: GA; smart00844 703339004357 GA module; Region: GA; smart00844 703339004358 GA module; Region: GA; smart00844 703339004359 GA module; Region: GA; smart00844 703339004360 GA module; Region: GA; smart00844 703339004361 chromosome segregation protein; Provisional; Region: PRK02224 703339004362 GA module; Region: GA; smart00844 703339004363 GA module; Region: GA; smart00844 703339004364 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 703339004365 GA module; Region: GA; pfam01468 703339004366 GA module; Region: GA; smart00844 703339004367 GA module; Region: GA; smart00844 703339004368 GA module; Region: GA; smart00844 703339004369 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 703339004370 Amino acid permease; Region: AA_permease_2; pfam13520 703339004371 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 703339004372 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 703339004373 tetramer interface [polypeptide binding]; other site 703339004374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339004375 catalytic residue [active] 703339004376 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 703339004377 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 703339004378 hexamer interface [polypeptide binding]; other site 703339004379 ligand binding site [chemical binding]; other site 703339004380 putative active site [active] 703339004381 NAD(P) binding site [chemical binding]; other site 703339004382 5'-3' exonuclease; Region: 53EXOc; smart00475 703339004383 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 703339004384 active site 703339004385 metal binding site 1 [ion binding]; metal-binding site 703339004386 putative 5' ssDNA interaction site; other site 703339004387 metal binding site 3; metal-binding site 703339004388 metal binding site 2 [ion binding]; metal-binding site 703339004389 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 703339004390 putative DNA binding site [nucleotide binding]; other site 703339004391 putative metal binding site [ion binding]; other site 703339004392 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 703339004393 Dynamin family; Region: Dynamin_N; pfam00350 703339004394 G1 box; other site 703339004395 GTP/Mg2+ binding site [chemical binding]; other site 703339004396 G2 box; other site 703339004397 Switch I region; other site 703339004398 G3 box; other site 703339004399 Switch II region; other site 703339004400 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 703339004401 G4 box; other site 703339004402 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 703339004403 Dynamin family; Region: Dynamin_N; pfam00350 703339004404 G1 box; other site 703339004405 GTP/Mg2+ binding site [chemical binding]; other site 703339004406 G2 box; other site 703339004407 Switch I region; other site 703339004408 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 703339004409 G3 box; other site 703339004410 Switch II region; other site 703339004411 GTP/Mg2+ binding site [chemical binding]; other site 703339004412 G4 box; other site 703339004413 G5 box; other site 703339004414 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 703339004415 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 703339004416 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 703339004417 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 703339004418 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 703339004419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 703339004420 cell division protein GpsB; Provisional; Region: PRK14127 703339004421 DivIVA domain; Region: DivI1A_domain; TIGR03544 703339004422 hypothetical protein; Provisional; Region: PRK13660 703339004423 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 703339004424 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 703339004425 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 703339004426 Transglycosylase; Region: Transgly; pfam00912 703339004427 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 703339004428 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 703339004429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 703339004430 minor groove reading motif; other site 703339004431 helix-hairpin-helix signature motif; other site 703339004432 substrate binding pocket [chemical binding]; other site 703339004433 active site 703339004434 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 703339004435 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 703339004436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 703339004437 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 703339004438 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 703339004439 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 703339004440 putative dimer interface [polypeptide binding]; other site 703339004441 putative anticodon binding site; other site 703339004442 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 703339004443 homodimer interface [polypeptide binding]; other site 703339004444 motif 1; other site 703339004445 motif 2; other site 703339004446 active site 703339004447 motif 3; other site 703339004448 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 703339004449 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 703339004450 active site 703339004451 catalytic site [active] 703339004452 substrate binding site [chemical binding]; other site 703339004453 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 703339004454 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 703339004455 Biotin operon repressor [Transcription]; Region: BirA; COG1654 703339004456 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 703339004457 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 703339004458 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 703339004459 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 703339004460 active site 703339004461 NTP binding site [chemical binding]; other site 703339004462 metal binding triad [ion binding]; metal-binding site 703339004463 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 703339004464 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 703339004465 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 703339004466 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 703339004467 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 703339004468 homodimer interface [polypeptide binding]; other site 703339004469 metal binding site [ion binding]; metal-binding site 703339004470 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 703339004471 Predicted membrane protein [Function unknown]; Region: COG4347 703339004472 Uncharacterized conserved protein [Function unknown]; Region: COG5582 703339004473 UPF0302 domain; Region: UPF0302; pfam08864 703339004474 A short protein domain of unknown function; Region: IDEAL; smart00914 703339004475 TPR repeat; Region: TPR_11; pfam13414 703339004476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 703339004477 binding surface 703339004478 TPR motif; other site 703339004479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 703339004480 TPR motif; other site 703339004481 binding surface 703339004482 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 703339004483 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 703339004484 hinge; other site 703339004485 active site 703339004486 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 703339004487 active site 703339004488 NAD binding site [chemical binding]; other site 703339004489 metal binding site [ion binding]; metal-binding site 703339004490 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 703339004491 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 703339004492 Tetramer interface [polypeptide binding]; other site 703339004493 active site 703339004494 FMN-binding site [chemical binding]; other site 703339004495 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 703339004496 active site 703339004497 multimer interface [polypeptide binding]; other site 703339004498 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 703339004499 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 703339004500 substrate binding pocket [chemical binding]; other site 703339004501 chain length determination region; other site 703339004502 substrate-Mg2+ binding site; other site 703339004503 catalytic residues [active] 703339004504 aspartate-rich region 1; other site 703339004505 active site lid residues [active] 703339004506 aspartate-rich region 2; other site 703339004507 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 703339004508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339004509 S-adenosylmethionine binding site [chemical binding]; other site 703339004510 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 703339004511 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 703339004512 IHF dimer interface [polypeptide binding]; other site 703339004513 IHF - DNA interface [nucleotide binding]; other site 703339004514 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 703339004515 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 703339004516 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 703339004517 GTP-binding protein Der; Reviewed; Region: PRK00093 703339004518 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 703339004519 G1 box; other site 703339004520 GTP/Mg2+ binding site [chemical binding]; other site 703339004521 Switch I region; other site 703339004522 G2 box; other site 703339004523 Switch II region; other site 703339004524 G3 box; other site 703339004525 G4 box; other site 703339004526 G5 box; other site 703339004527 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 703339004528 G1 box; other site 703339004529 GTP/Mg2+ binding site [chemical binding]; other site 703339004530 Switch I region; other site 703339004531 G2 box; other site 703339004532 G3 box; other site 703339004533 Switch II region; other site 703339004534 G4 box; other site 703339004535 G5 box; other site 703339004536 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 703339004537 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 703339004538 RNA binding site [nucleotide binding]; other site 703339004539 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 703339004540 RNA binding site [nucleotide binding]; other site 703339004541 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 703339004542 RNA binding site [nucleotide binding]; other site 703339004543 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 703339004544 RNA binding site [nucleotide binding]; other site 703339004545 cytidylate kinase; Provisional; Region: cmk; PRK00023 703339004546 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 703339004547 CMP-binding site; other site 703339004548 The sites determining sugar specificity; other site 703339004549 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 703339004550 active site 703339004551 homotetramer interface [polypeptide binding]; other site 703339004552 homodimer interface [polypeptide binding]; other site 703339004553 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 703339004554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 703339004555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339004556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 703339004557 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 703339004558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339004559 ATP binding site [chemical binding]; other site 703339004560 putative Mg++ binding site [ion binding]; other site 703339004561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339004562 nucleotide binding region [chemical binding]; other site 703339004563 ATP-binding site [chemical binding]; other site 703339004564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 703339004565 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 703339004566 Predicted membrane protein [Function unknown]; Region: COG3601 703339004567 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 703339004568 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 703339004569 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 703339004570 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 703339004571 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 703339004572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 703339004573 dimerization interface [polypeptide binding]; other site 703339004574 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 703339004575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339004576 dimer interface [polypeptide binding]; other site 703339004577 phosphorylation site [posttranslational modification] 703339004578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339004579 ATP binding site [chemical binding]; other site 703339004580 Mg2+ binding site [ion binding]; other site 703339004581 G-X-G motif; other site 703339004582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339004583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339004584 active site 703339004585 phosphorylation site [posttranslational modification] 703339004586 intermolecular recognition site; other site 703339004587 dimerization interface [polypeptide binding]; other site 703339004588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339004589 DNA binding site [nucleotide binding] 703339004590 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 703339004591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339004592 RNA binding surface [nucleotide binding]; other site 703339004593 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 703339004594 active site 703339004595 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 703339004596 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 703339004597 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 703339004598 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 703339004599 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 703339004600 active site 703339004601 Int/Topo IB signature motif; other site 703339004602 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 703339004603 metal binding site 2 [ion binding]; metal-binding site 703339004604 putative DNA binding helix; other site 703339004605 metal binding site 1 [ion binding]; metal-binding site 703339004606 dimer interface [polypeptide binding]; other site 703339004607 structural Zn2+ binding site [ion binding]; other site 703339004608 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 703339004609 dimer interface [polypeptide binding]; other site 703339004610 ADP-ribose binding site [chemical binding]; other site 703339004611 active site 703339004612 nudix motif; other site 703339004613 metal binding site [ion binding]; metal-binding site 703339004614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 703339004615 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 703339004616 active site 703339004617 catalytic tetrad [active] 703339004618 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 703339004619 classical (c) SDRs; Region: SDR_c; cd05233 703339004620 NAD(P) binding site [chemical binding]; other site 703339004621 active site 703339004622 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 703339004623 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 703339004624 ribonuclease Z; Region: RNase_Z; TIGR02651 703339004625 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 703339004626 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 703339004627 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 703339004628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 703339004629 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 703339004630 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 703339004631 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 703339004632 Ca binding site [ion binding]; other site 703339004633 active site 703339004634 catalytic site [active] 703339004635 Transcriptional regulators [Transcription]; Region: PurR; COG1609 703339004636 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 703339004637 DNA binding site [nucleotide binding] 703339004638 domain linker motif; other site 703339004639 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 703339004640 putative ligand binding site [chemical binding]; other site 703339004641 putative dimerization interface [polypeptide binding]; other site 703339004642 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 703339004643 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 703339004644 H+ Antiporter protein; Region: 2A0121; TIGR00900 703339004645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339004646 putative substrate translocation pore; other site 703339004647 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 703339004648 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 703339004649 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 703339004650 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 703339004651 peptidase T-like protein; Region: PepT-like; TIGR01883 703339004652 metal binding site [ion binding]; metal-binding site 703339004653 putative dimer interface [polypeptide binding]; other site 703339004654 Predicted membrane protein [Function unknown]; Region: COG4129 703339004655 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 703339004656 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 703339004657 Disulphide isomerase; Region: Disulph_isomer; pfam06491 703339004658 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 703339004659 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 703339004660 E3 interaction surface; other site 703339004661 lipoyl attachment site [posttranslational modification]; other site 703339004662 e3 binding domain; Region: E3_binding; pfam02817 703339004663 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 703339004664 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 703339004665 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 703339004666 alpha subunit interface [polypeptide binding]; other site 703339004667 TPP binding site [chemical binding]; other site 703339004668 heterodimer interface [polypeptide binding]; other site 703339004669 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 703339004670 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 703339004671 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 703339004672 tetramer interface [polypeptide binding]; other site 703339004673 TPP-binding site [chemical binding]; other site 703339004674 heterodimer interface [polypeptide binding]; other site 703339004675 phosphorylation loop region [posttranslational modification] 703339004676 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 703339004677 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 703339004678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339004679 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 703339004680 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 703339004681 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 703339004682 Walker A/P-loop; other site 703339004683 ATP binding site [chemical binding]; other site 703339004684 Q-loop/lid; other site 703339004685 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 703339004686 ABC transporter signature motif; other site 703339004687 Walker B; other site 703339004688 D-loop; other site 703339004689 H-loop/switch region; other site 703339004690 arginine repressor; Provisional; Region: PRK04280 703339004691 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 703339004692 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 703339004693 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 703339004694 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 703339004695 substrate binding pocket [chemical binding]; other site 703339004696 chain length determination region; other site 703339004697 substrate-Mg2+ binding site; other site 703339004698 catalytic residues [active] 703339004699 aspartate-rich region 1; other site 703339004700 active site lid residues [active] 703339004701 aspartate-rich region 2; other site 703339004702 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 703339004703 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 703339004704 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 703339004705 generic binding surface II; other site 703339004706 generic binding surface I; other site 703339004707 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 703339004708 putative RNA binding site [nucleotide binding]; other site 703339004709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 703339004710 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 703339004711 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 703339004712 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 703339004713 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 703339004714 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 703339004715 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 703339004716 carboxyltransferase (CT) interaction site; other site 703339004717 biotinylation site [posttranslational modification]; other site 703339004718 elongation factor P; Validated; Region: PRK00529 703339004719 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 703339004720 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 703339004721 RNA binding site [nucleotide binding]; other site 703339004722 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 703339004723 RNA binding site [nucleotide binding]; other site 703339004724 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 703339004725 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 703339004726 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 703339004727 active site 703339004728 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 703339004729 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 703339004730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 703339004731 active site residue [active] 703339004732 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 703339004733 tetramer interface [polypeptide binding]; other site 703339004734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339004735 catalytic residue [active] 703339004736 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 703339004737 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 703339004738 tetramer interface [polypeptide binding]; other site 703339004739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339004740 catalytic residue [active] 703339004741 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 703339004742 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 703339004743 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 703339004744 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 703339004745 ADP binding site [chemical binding]; other site 703339004746 magnesium binding site [ion binding]; other site 703339004747 putative shikimate binding site; other site 703339004748 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 703339004749 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 703339004750 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 703339004751 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 703339004752 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 703339004753 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 703339004754 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 703339004755 Type II/IV secretion system protein; Region: T2SE; pfam00437 703339004756 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 703339004757 Walker A motif; other site 703339004758 ATP binding site [chemical binding]; other site 703339004759 Walker B motif; other site 703339004760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 703339004761 Uncharacterized conserved protein [Function unknown]; Region: COG0011 703339004762 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 703339004763 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 703339004764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 703339004765 Rhomboid family; Region: Rhomboid; pfam01694 703339004766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 703339004767 binding surface 703339004768 TPR motif; other site 703339004769 Tetratricopeptide repeat; Region: TPR_16; pfam13432 703339004770 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 703339004771 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 703339004772 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 703339004773 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 703339004774 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 703339004775 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 703339004776 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 703339004777 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 703339004778 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 703339004779 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 703339004780 metal binding site 2 [ion binding]; metal-binding site 703339004781 putative DNA binding helix; other site 703339004782 metal binding site 1 [ion binding]; metal-binding site 703339004783 dimer interface [polypeptide binding]; other site 703339004784 structural Zn2+ binding site [ion binding]; other site 703339004785 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 703339004786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339004787 ABC-ATPase subunit interface; other site 703339004788 dimer interface [polypeptide binding]; other site 703339004789 putative PBP binding regions; other site 703339004790 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 703339004791 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 703339004792 endonuclease IV; Provisional; Region: PRK01060 703339004793 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 703339004794 AP (apurinic/apyrimidinic) site pocket; other site 703339004795 DNA interaction; other site 703339004796 Metal-binding active site; metal-binding site 703339004797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 703339004798 DEAD-like helicases superfamily; Region: DEXDc; smart00487 703339004799 ATP binding site [chemical binding]; other site 703339004800 putative Mg++ binding site [ion binding]; other site 703339004801 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339004802 nucleotide binding region [chemical binding]; other site 703339004803 ATP-binding site [chemical binding]; other site 703339004804 Uncharacterized conserved protein [Function unknown]; Region: COG0327 703339004805 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 703339004806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 703339004807 Uncharacterized conserved protein [Function unknown]; Region: COG0327 703339004808 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 703339004809 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 703339004810 Family of unknown function (DUF633); Region: DUF633; pfam04816 703339004811 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 703339004812 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 703339004813 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 703339004814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 703339004815 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 703339004816 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 703339004817 DNA binding residues [nucleotide binding] 703339004818 DNA primase, catalytic core; Region: dnaG; TIGR01391 703339004819 CHC2 zinc finger; Region: zf-CHC2; pfam01807 703339004820 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 703339004821 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 703339004822 active site 703339004823 metal binding site [ion binding]; metal-binding site 703339004824 interdomain interaction site; other site 703339004825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 703339004826 HTH domain; Region: HTH_11; pfam08279 703339004827 FOG: CBS domain [General function prediction only]; Region: COG0517 703339004828 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 703339004829 glycyl-tRNA synthetase; Provisional; Region: PRK04173 703339004830 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 703339004831 motif 1; other site 703339004832 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 703339004833 active site 703339004834 motif 2; other site 703339004835 motif 3; other site 703339004836 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 703339004837 anticodon binding site; other site 703339004838 DNA repair protein RecO; Region: reco; TIGR00613 703339004839 Recombination protein O N terminal; Region: RecO_N; pfam11967 703339004840 Recombination protein O C terminal; Region: RecO_C; pfam02565 703339004841 GTPase Era; Reviewed; Region: era; PRK00089 703339004842 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 703339004843 G1 box; other site 703339004844 GTP/Mg2+ binding site [chemical binding]; other site 703339004845 Switch I region; other site 703339004846 G2 box; other site 703339004847 Switch II region; other site 703339004848 G3 box; other site 703339004849 G4 box; other site 703339004850 G5 box; other site 703339004851 KH domain; Region: KH_2; pfam07650 703339004852 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 703339004853 active site 703339004854 catalytic motif [active] 703339004855 Zn binding site [ion binding]; other site 703339004856 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 703339004857 metal-binding heat shock protein; Provisional; Region: PRK00016 703339004858 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 703339004859 PhoH-like protein; Region: PhoH; pfam02562 703339004860 hypothetical protein; Provisional; Region: PRK13665 703339004861 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 703339004862 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 703339004863 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 703339004864 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 703339004865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339004866 FeS/SAM binding site; other site 703339004867 TRAM domain; Region: TRAM; cl01282 703339004868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 703339004869 RNA methyltransferase, RsmE family; Region: TIGR00046 703339004870 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 703339004871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339004872 S-adenosylmethionine binding site [chemical binding]; other site 703339004873 chaperone protein DnaJ; Provisional; Region: PRK14280 703339004874 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 703339004875 HSP70 interaction site [polypeptide binding]; other site 703339004876 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 703339004877 substrate binding site [polypeptide binding]; other site 703339004878 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 703339004879 Zn binding sites [ion binding]; other site 703339004880 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 703339004881 dimer interface [polypeptide binding]; other site 703339004882 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 703339004883 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 703339004884 nucleotide binding site [chemical binding]; other site 703339004885 NEF interaction site [polypeptide binding]; other site 703339004886 SBD interface [polypeptide binding]; other site 703339004887 heat shock protein GrpE; Provisional; Region: PRK14140 703339004888 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 703339004889 dimer interface [polypeptide binding]; other site 703339004890 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 703339004891 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 703339004892 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 703339004893 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 703339004894 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 703339004895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339004896 FeS/SAM binding site; other site 703339004897 HemN C-terminal domain; Region: HemN_C; pfam06969 703339004898 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339004899 GTP-binding protein LepA; Provisional; Region: PRK05433 703339004900 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 703339004901 G1 box; other site 703339004902 putative GEF interaction site [polypeptide binding]; other site 703339004903 GTP/Mg2+ binding site [chemical binding]; other site 703339004904 Switch I region; other site 703339004905 G2 box; other site 703339004906 G3 box; other site 703339004907 Switch II region; other site 703339004908 G4 box; other site 703339004909 G5 box; other site 703339004910 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 703339004911 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 703339004912 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 703339004913 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 703339004914 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 703339004915 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 703339004916 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 703339004917 Competence protein; Region: Competence; pfam03772 703339004918 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 703339004919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 703339004920 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 703339004921 catalytic motif [active] 703339004922 Zn binding site [ion binding]; other site 703339004923 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 703339004924 Helix-hairpin-helix motif; Region: HHH; pfam00633 703339004925 Methyltransferase domain; Region: Methyltransf_31; pfam13847 703339004926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339004927 S-adenosylmethionine binding site [chemical binding]; other site 703339004928 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 703339004929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 703339004930 Zn2+ binding site [ion binding]; other site 703339004931 Mg2+ binding site [ion binding]; other site 703339004932 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 703339004933 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 703339004934 active site 703339004935 (T/H)XGH motif; other site 703339004936 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 703339004937 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 703339004938 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 703339004939 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 703339004940 shikimate binding site; other site 703339004941 NAD(P) binding site [chemical binding]; other site 703339004942 GTPase YqeH; Provisional; Region: PRK13796 703339004943 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 703339004944 GTP/Mg2+ binding site [chemical binding]; other site 703339004945 G4 box; other site 703339004946 G5 box; other site 703339004947 G1 box; other site 703339004948 Switch I region; other site 703339004949 G2 box; other site 703339004950 G3 box; other site 703339004951 Switch II region; other site 703339004952 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 703339004953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339004954 active site 703339004955 motif I; other site 703339004956 motif II; other site 703339004957 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 703339004958 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 703339004959 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339004960 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339004961 Fic family protein [Function unknown]; Region: COG3177 703339004962 Fic/DOC family; Region: Fic; pfam02661 703339004963 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 703339004964 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 703339004965 putative active site [active] 703339004966 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 703339004967 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 703339004968 ATP-grasp domain; Region: ATP-grasp_4; cl17255 703339004969 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 703339004970 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 703339004971 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 703339004972 carboxyltransferase (CT) interaction site; other site 703339004973 biotinylation site [posttranslational modification]; other site 703339004974 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 703339004975 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 703339004976 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 703339004977 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 703339004978 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 703339004979 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 703339004980 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 703339004981 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 703339004982 Sugar specificity; other site 703339004983 Pyrimidine base specificity; other site 703339004984 ATP-binding site [chemical binding]; other site 703339004985 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 703339004986 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 703339004987 Peptidase family U32; Region: Peptidase_U32; pfam01136 703339004988 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 703339004989 Peptidase family U32; Region: Peptidase_U32; pfam01136 703339004990 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 703339004991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339004992 S-adenosylmethionine binding site [chemical binding]; other site 703339004993 hypothetical protein; Provisional; Region: PRK13678 703339004994 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 703339004995 hypothetical protein; Provisional; Region: PRK05473 703339004996 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 703339004997 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 703339004998 motif 1; other site 703339004999 active site 703339005000 motif 2; other site 703339005001 motif 3; other site 703339005002 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 703339005003 DHHA1 domain; Region: DHHA1; pfam02272 703339005004 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 703339005005 AAA domain; Region: AAA_30; pfam13604 703339005006 Family description; Region: UvrD_C_2; pfam13538 703339005007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 703339005008 binding surface 703339005009 TPR motif; other site 703339005010 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 703339005011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 703339005012 binding surface 703339005013 TPR motif; other site 703339005014 TPR repeat; Region: TPR_11; pfam13414 703339005015 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 703339005016 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 703339005017 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 703339005018 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 703339005019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339005020 catalytic residue [active] 703339005021 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 703339005022 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 703339005023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 703339005024 Predicted transcriptional regulator [Transcription]; Region: COG1959 703339005025 Transcriptional regulator; Region: Rrf2; pfam02082 703339005026 recombination factor protein RarA; Reviewed; Region: PRK13342 703339005027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339005028 Walker A motif; other site 703339005029 ATP binding site [chemical binding]; other site 703339005030 Walker B motif; other site 703339005031 arginine finger; other site 703339005032 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 703339005033 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 703339005034 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 703339005035 putative ATP binding site [chemical binding]; other site 703339005036 putative substrate interface [chemical binding]; other site 703339005037 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 703339005038 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 703339005039 dimer interface [polypeptide binding]; other site 703339005040 anticodon binding site; other site 703339005041 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 703339005042 homodimer interface [polypeptide binding]; other site 703339005043 motif 1; other site 703339005044 active site 703339005045 motif 2; other site 703339005046 GAD domain; Region: GAD; pfam02938 703339005047 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 703339005048 motif 3; other site 703339005049 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 703339005050 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 703339005051 dimer interface [polypeptide binding]; other site 703339005052 motif 1; other site 703339005053 active site 703339005054 motif 2; other site 703339005055 motif 3; other site 703339005056 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 703339005057 anticodon binding site; other site 703339005058 Bacterial SH3 domain homologues; Region: SH3b; smart00287 703339005059 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 703339005060 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 703339005061 active site 703339005062 metal binding site [ion binding]; metal-binding site 703339005063 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 703339005064 putative active site [active] 703339005065 dimerization interface [polypeptide binding]; other site 703339005066 putative tRNAtyr binding site [nucleotide binding]; other site 703339005067 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 703339005068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 703339005069 Zn2+ binding site [ion binding]; other site 703339005070 Mg2+ binding site [ion binding]; other site 703339005071 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 703339005072 synthetase active site [active] 703339005073 NTP binding site [chemical binding]; other site 703339005074 metal binding site [ion binding]; metal-binding site 703339005075 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 703339005076 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 703339005077 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339005078 active site 703339005079 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 703339005080 DHH family; Region: DHH; pfam01368 703339005081 DHHA1 domain; Region: DHHA1; pfam02272 703339005082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 703339005083 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 703339005084 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 703339005085 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 703339005086 Protein export membrane protein; Region: SecD_SecF; pfam02355 703339005087 Preprotein translocase subunit; Region: YajC; pfam02699 703339005088 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 703339005089 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 703339005090 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 703339005091 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 703339005092 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 703339005093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339005094 Walker A motif; other site 703339005095 ATP binding site [chemical binding]; other site 703339005096 Walker B motif; other site 703339005097 arginine finger; other site 703339005098 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 703339005099 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 703339005100 RuvA N terminal domain; Region: RuvA_N; pfam01330 703339005101 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 703339005102 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 703339005103 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 703339005104 GTPase CgtA; Reviewed; Region: obgE; PRK12297 703339005105 GTP1/OBG; Region: GTP1_OBG; pfam01018 703339005106 Obg GTPase; Region: Obg; cd01898 703339005107 G1 box; other site 703339005108 GTP/Mg2+ binding site [chemical binding]; other site 703339005109 Switch I region; other site 703339005110 G2 box; other site 703339005111 G3 box; other site 703339005112 Switch II region; other site 703339005113 G4 box; other site 703339005114 G5 box; other site 703339005115 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 703339005116 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 703339005117 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 703339005118 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 703339005119 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 703339005120 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 703339005121 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 703339005122 rod shape-determining protein MreC; Region: MreC; pfam04085 703339005123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005124 S-adenosylmethionine binding site [chemical binding]; other site 703339005125 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 703339005126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005127 S-adenosylmethionine binding site [chemical binding]; other site 703339005128 aminoglycoside resistance protein; Provisional; Region: PRK13746 703339005129 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 703339005130 active site 703339005131 NTP binding site [chemical binding]; other site 703339005132 metal binding triad [ion binding]; metal-binding site 703339005133 antibiotic binding site [chemical binding]; other site 703339005134 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 703339005135 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 703339005136 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 703339005137 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 703339005138 Int/Topo IB signature motif; other site 703339005139 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 703339005140 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 703339005141 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 703339005142 Int/Topo IB signature motif; other site 703339005143 hypothetical protein; Reviewed; Region: PRK00024 703339005144 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 703339005145 MPN+ (JAMM) motif; other site 703339005146 Zinc-binding site [ion binding]; other site 703339005147 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 703339005148 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 703339005149 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 703339005150 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 703339005151 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 703339005152 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 703339005153 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 703339005154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 703339005155 active site 703339005156 HIGH motif; other site 703339005157 nucleotide binding site [chemical binding]; other site 703339005158 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 703339005159 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 703339005160 active site 703339005161 KMSKS motif; other site 703339005162 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 703339005163 tRNA binding surface [nucleotide binding]; other site 703339005164 anticodon binding site; other site 703339005165 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 703339005166 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 703339005167 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 703339005168 Putative ammonia monooxygenase; Region: AmoA; pfam05145 703339005169 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 703339005170 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 703339005171 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 703339005172 inhibitor-cofactor binding pocket; inhibition site 703339005173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339005174 catalytic residue [active] 703339005175 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 703339005176 dimer interface [polypeptide binding]; other site 703339005177 active site 703339005178 Schiff base residues; other site 703339005179 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 703339005180 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 703339005181 active site 703339005182 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 703339005183 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 703339005184 domain interfaces; other site 703339005185 active site 703339005186 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 703339005187 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 703339005188 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 703339005189 tRNA; other site 703339005190 putative tRNA binding site [nucleotide binding]; other site 703339005191 putative NADP binding site [chemical binding]; other site 703339005192 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 703339005193 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 703339005194 G1 box; other site 703339005195 GTP/Mg2+ binding site [chemical binding]; other site 703339005196 Switch I region; other site 703339005197 G2 box; other site 703339005198 G3 box; other site 703339005199 Switch II region; other site 703339005200 G4 box; other site 703339005201 G5 box; other site 703339005202 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 703339005203 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 703339005204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339005205 Walker A motif; other site 703339005206 ATP binding site [chemical binding]; other site 703339005207 Walker B motif; other site 703339005208 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 703339005209 trigger factor; Provisional; Region: tig; PRK01490 703339005210 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 703339005211 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 703339005212 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 703339005213 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 703339005214 23S rRNA binding site [nucleotide binding]; other site 703339005215 L21 binding site [polypeptide binding]; other site 703339005216 L13 binding site [polypeptide binding]; other site 703339005217 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 703339005218 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 703339005219 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 703339005220 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 703339005221 lysine transporter; Provisional; Region: PRK10836 703339005222 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 703339005223 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 703339005224 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 703339005225 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 703339005226 active site 703339005227 dimer interface [polypeptide binding]; other site 703339005228 motif 1; other site 703339005229 motif 2; other site 703339005230 motif 3; other site 703339005231 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 703339005232 anticodon binding site; other site 703339005233 primosomal protein DnaI; Reviewed; Region: PRK08939 703339005234 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 703339005235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339005236 Walker A motif; other site 703339005237 ATP binding site [chemical binding]; other site 703339005238 Walker B motif; other site 703339005239 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 703339005240 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 703339005241 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 703339005242 ATP cone domain; Region: ATP-cone; pfam03477 703339005243 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 703339005244 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 703339005245 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 703339005246 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 703339005247 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 703339005248 CoA-binding site [chemical binding]; other site 703339005249 ATP-binding [chemical binding]; other site 703339005250 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 703339005251 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 703339005252 DNA binding site [nucleotide binding] 703339005253 catalytic residue [active] 703339005254 H2TH interface [polypeptide binding]; other site 703339005255 putative catalytic residues [active] 703339005256 turnover-facilitating residue; other site 703339005257 intercalation triad [nucleotide binding]; other site 703339005258 8OG recognition residue [nucleotide binding]; other site 703339005259 putative reading head residues; other site 703339005260 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 703339005261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 703339005262 DNA polymerase I; Provisional; Region: PRK05755 703339005263 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 703339005264 active site 703339005265 metal binding site 1 [ion binding]; metal-binding site 703339005266 putative 5' ssDNA interaction site; other site 703339005267 metal binding site 3; metal-binding site 703339005268 metal binding site 2 [ion binding]; metal-binding site 703339005269 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 703339005270 putative DNA binding site [nucleotide binding]; other site 703339005271 putative metal binding site [ion binding]; other site 703339005272 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 703339005273 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 703339005274 active site 703339005275 DNA binding site [nucleotide binding] 703339005276 catalytic site [active] 703339005277 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 703339005278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339005279 dimer interface [polypeptide binding]; other site 703339005280 phosphorylation site [posttranslational modification] 703339005281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339005282 ATP binding site [chemical binding]; other site 703339005283 Mg2+ binding site [ion binding]; other site 703339005284 G-X-G motif; other site 703339005285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339005286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339005287 active site 703339005288 phosphorylation site [posttranslational modification] 703339005289 intermolecular recognition site; other site 703339005290 dimerization interface [polypeptide binding]; other site 703339005291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339005292 DNA binding site [nucleotide binding] 703339005293 isocitrate dehydrogenase; Reviewed; Region: PRK07006 703339005294 isocitrate dehydrogenase; Validated; Region: PRK07362 703339005295 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 703339005296 dimer interface [polypeptide binding]; other site 703339005297 Citrate synthase; Region: Citrate_synt; pfam00285 703339005298 active site 703339005299 citrylCoA binding site [chemical binding]; other site 703339005300 oxalacetate/citrate binding site [chemical binding]; other site 703339005301 coenzyme A binding site [chemical binding]; other site 703339005302 catalytic triad [active] 703339005303 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 703339005304 pyruvate kinase; Provisional; Region: PRK06354 703339005305 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 703339005306 domain interfaces; other site 703339005307 active site 703339005308 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 703339005309 6-phosphofructokinase; Provisional; Region: PRK03202 703339005310 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 703339005311 dimerization interface [polypeptide binding]; other site 703339005312 allosteric effector site; other site 703339005313 active site 703339005314 ADP/pyrophosphate binding site [chemical binding]; other site 703339005315 fructose-1,6-bisphosphate binding site; other site 703339005316 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 703339005317 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 703339005318 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 703339005319 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 703339005320 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 703339005321 Malic enzyme, N-terminal domain; Region: malic; pfam00390 703339005322 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 703339005323 putative NAD(P) binding site [chemical binding]; other site 703339005324 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 703339005325 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 703339005326 active site 703339005327 PHP Thumb interface [polypeptide binding]; other site 703339005328 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 703339005329 generic binding surface I; other site 703339005330 generic binding surface II; other site 703339005331 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 703339005332 DHH family; Region: DHH; pfam01368 703339005333 DHHA1 domain; Region: DHHA1; pfam02272 703339005334 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 703339005335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 703339005336 DNA-binding site [nucleotide binding]; DNA binding site 703339005337 DRTGG domain; Region: DRTGG; pfam07085 703339005338 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 703339005339 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 703339005340 active site 2 [active] 703339005341 active site 1 [active] 703339005342 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 703339005343 Ligand Binding Site [chemical binding]; other site 703339005344 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 703339005345 metal-dependent hydrolase; Provisional; Region: PRK00685 703339005346 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 703339005347 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 703339005348 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 703339005349 active site 703339005350 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 703339005351 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 703339005352 hexamer interface [polypeptide binding]; other site 703339005353 ligand binding site [chemical binding]; other site 703339005354 putative active site [active] 703339005355 NAD(P) binding site [chemical binding]; other site 703339005356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 703339005357 Ligand Binding Site [chemical binding]; other site 703339005358 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 703339005359 propionate/acetate kinase; Provisional; Region: PRK12379 703339005360 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 703339005361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005362 S-adenosylmethionine binding site [chemical binding]; other site 703339005363 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 703339005364 dimer interface [polypeptide binding]; other site 703339005365 catalytic triad [active] 703339005366 peroxidatic and resolving cysteines [active] 703339005367 hypothetical protein; Provisional; Region: PRK10621 703339005368 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 703339005369 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 703339005370 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 703339005371 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 703339005372 Ligand Binding Site [chemical binding]; other site 703339005373 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 703339005374 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 703339005375 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339005376 catalytic residue [active] 703339005377 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 703339005378 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 703339005379 GAF domain; Region: GAF_2; pfam13185 703339005380 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 703339005381 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 703339005382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339005383 RNA binding surface [nucleotide binding]; other site 703339005384 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 703339005385 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 703339005386 active site 703339005387 catalytic site [active] 703339005388 OsmC-like protein; Region: OsmC; cl00767 703339005389 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 703339005390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339005391 catalytic residue [active] 703339005392 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 703339005393 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 703339005394 ligand binding site [chemical binding]; other site 703339005395 NAD binding site [chemical binding]; other site 703339005396 dimerization interface [polypeptide binding]; other site 703339005397 catalytic site [active] 703339005398 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 703339005399 putative L-serine binding site [chemical binding]; other site 703339005400 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 703339005401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339005402 motif II; other site 703339005403 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 703339005404 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339005405 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339005406 active site turn [active] 703339005407 phosphorylation site [posttranslational modification] 703339005408 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 703339005409 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 703339005410 putative acyl-acceptor binding pocket; other site 703339005411 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 703339005412 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 703339005413 protein binding site [polypeptide binding]; other site 703339005414 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 703339005415 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 703339005416 active site 703339005417 HIGH motif; other site 703339005418 dimer interface [polypeptide binding]; other site 703339005419 KMSKS motif; other site 703339005420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339005421 RNA binding surface [nucleotide binding]; other site 703339005422 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 703339005423 Transglycosylase; Region: Transgly; pfam00912 703339005424 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 703339005425 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 703339005426 NEAr Transporter domain; Region: NEAT; smart00725 703339005427 NEAr Transporter domain; Region: NEAT; smart00725 703339005428 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 703339005429 heme-binding site [chemical binding]; other site 703339005430 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 703339005431 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 703339005432 Potassium binding sites [ion binding]; other site 703339005433 Cesium cation binding sites [ion binding]; other site 703339005434 acetyl-CoA synthetase; Provisional; Region: PRK04319 703339005435 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 703339005436 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 703339005437 active site 703339005438 acyl-activating enzyme (AAE) consensus motif; other site 703339005439 putative CoA binding site [chemical binding]; other site 703339005440 AMP binding site [chemical binding]; other site 703339005441 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 703339005442 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 703339005443 active site 703339005444 Zn binding site [ion binding]; other site 703339005445 catabolite control protein A; Region: ccpA; TIGR01481 703339005446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 703339005447 DNA binding site [nucleotide binding] 703339005448 domain linker motif; other site 703339005449 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 703339005450 dimerization interface [polypeptide binding]; other site 703339005451 effector binding site; other site 703339005452 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 703339005453 Chorismate mutase type II; Region: CM_2; cl00693 703339005454 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 703339005455 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 703339005456 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 703339005457 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 703339005458 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 703339005459 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 703339005460 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 703339005461 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 703339005462 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 703339005463 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 703339005464 putative tRNA-binding site [nucleotide binding]; other site 703339005465 hypothetical protein; Provisional; Region: PRK13668 703339005466 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 703339005467 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 703339005468 catalytic residues [active] 703339005469 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 703339005470 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 703339005471 oligomer interface [polypeptide binding]; other site 703339005472 active site 703339005473 metal binding site [ion binding]; metal-binding site 703339005474 Predicted small secreted protein [Function unknown]; Region: COG5584 703339005475 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 703339005476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005477 S-adenosylmethionine binding site [chemical binding]; other site 703339005478 Phosphotransferase enzyme family; Region: APH; pfam01636 703339005479 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 703339005480 active site 703339005481 substrate binding site [chemical binding]; other site 703339005482 ATP binding site [chemical binding]; other site 703339005483 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 703339005484 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 703339005485 homodimer interface [polypeptide binding]; other site 703339005486 substrate-cofactor binding pocket; other site 703339005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339005488 catalytic residue [active] 703339005489 dipeptidase PepV; Reviewed; Region: PRK07318 703339005490 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 703339005491 active site 703339005492 metal binding site [ion binding]; metal-binding site 703339005493 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 703339005494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 703339005495 RNA binding surface [nucleotide binding]; other site 703339005496 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 703339005497 active site 703339005498 uracil binding [chemical binding]; other site 703339005499 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 703339005500 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 703339005501 HI0933-like protein; Region: HI0933_like; pfam03486 703339005502 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339005503 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 703339005504 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005505 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005506 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005507 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005508 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005509 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005510 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005511 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005512 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005513 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005514 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005515 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005516 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005517 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005518 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339005519 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 703339005520 active site residue [active] 703339005521 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 703339005522 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 703339005523 HIGH motif; other site 703339005524 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 703339005525 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 703339005526 active site 703339005527 KMSKS motif; other site 703339005528 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 703339005529 tRNA binding surface [nucleotide binding]; other site 703339005530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339005531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339005532 putative substrate translocation pore; other site 703339005533 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 703339005534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005535 S-adenosylmethionine binding site [chemical binding]; other site 703339005536 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339005537 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 703339005538 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 703339005539 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 703339005540 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 703339005541 homopentamer interface [polypeptide binding]; other site 703339005542 active site 703339005543 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 703339005544 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 703339005545 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 703339005546 dimerization interface [polypeptide binding]; other site 703339005547 active site 703339005548 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 703339005549 Lumazine binding domain; Region: Lum_binding; pfam00677 703339005550 Lumazine binding domain; Region: Lum_binding; pfam00677 703339005551 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 703339005552 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 703339005553 catalytic motif [active] 703339005554 Zn binding site [ion binding]; other site 703339005555 RibD C-terminal domain; Region: RibD_C; cl17279 703339005556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 703339005557 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 703339005558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 703339005559 dimerization interface [polypeptide binding]; other site 703339005560 putative DNA binding site [nucleotide binding]; other site 703339005561 putative Zn2+ binding site [ion binding]; other site 703339005562 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 703339005563 arsenical pump membrane protein; Provisional; Region: PRK15445 703339005564 transmembrane helices; other site 703339005565 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 703339005566 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 703339005567 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 703339005568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 703339005569 DNA binding residues [nucleotide binding] 703339005570 CAAX protease self-immunity; Region: Abi; pfam02517 703339005571 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 703339005572 active site 703339005573 intersubunit interactions; other site 703339005574 catalytic residue [active] 703339005575 camphor resistance protein CrcB; Provisional; Region: PRK14201 703339005576 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 703339005577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 703339005578 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 703339005579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 703339005580 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 703339005581 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 703339005582 active site 703339005583 catalytic tetrad [active] 703339005584 S-adenosylmethionine synthetase; Validated; Region: PRK05250 703339005585 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 703339005586 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 703339005587 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 703339005588 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 703339005589 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 703339005590 active site 703339005591 substrate-binding site [chemical binding]; other site 703339005592 metal-binding site [ion binding] 703339005593 ATP binding site [chemical binding]; other site 703339005594 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 703339005595 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 703339005596 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 703339005597 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 703339005598 nudix motif; other site 703339005599 Haemolytic domain; Region: Haemolytic; pfam01809 703339005600 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 703339005601 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 703339005602 metal binding site [ion binding]; metal-binding site 703339005603 substrate binding pocket [chemical binding]; other site 703339005604 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 703339005605 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 703339005606 acyl-activating enzyme (AAE) consensus motif; other site 703339005607 putative AMP binding site [chemical binding]; other site 703339005608 putative active site [active] 703339005609 putative CoA binding site [chemical binding]; other site 703339005610 Excalibur calcium-binding domain; Region: Excalibur; smart00894 703339005611 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 703339005612 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 703339005613 Pathogenicity island SaPIn3 703339005614 Integrase core domain; Region: rve; pfam00665 703339005615 DDE domain; Region: DDE_Tnp_IS240; pfam13610 703339005616 Integrase core domain; Region: rve_3; pfam13683 703339005617 putative transposase OrfB; Reviewed; Region: PHA02517 703339005618 Winged helix-turn helix; Region: HTH_29; pfam13551 703339005619 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 703339005620 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 703339005621 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 703339005622 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 703339005623 HsdM N-terminal domain; Region: HsdM_N; pfam12161 703339005624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005625 S-adenosylmethionine binding site [chemical binding]; other site 703339005626 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339005627 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 703339005628 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339005629 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 703339005630 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339005631 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339005632 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339005633 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 703339005634 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 703339005635 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 703339005636 beta-channel forming cytolysin; Region: hlyII; TIGR01002 703339005637 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 703339005638 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 703339005639 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 703339005640 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 703339005641 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 703339005642 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339005643 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339005644 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339005645 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339005646 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339005647 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339005648 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339005649 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339005650 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339005651 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339005652 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339005653 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339005654 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 703339005655 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 703339005656 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 703339005657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 703339005658 ferrochelatase; Provisional; Region: PRK12435 703339005659 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 703339005660 C-terminal domain interface [polypeptide binding]; other site 703339005661 active site 703339005662 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 703339005663 active site 703339005664 N-terminal domain interface [polypeptide binding]; other site 703339005665 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 703339005666 substrate binding site [chemical binding]; other site 703339005667 active site 703339005668 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 703339005669 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 703339005670 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 703339005671 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339005672 Walker A/P-loop; other site 703339005673 ATP binding site [chemical binding]; other site 703339005674 Q-loop/lid; other site 703339005675 ABC transporter signature motif; other site 703339005676 Walker B; other site 703339005677 D-loop; other site 703339005678 H-loop/switch region; other site 703339005679 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 703339005680 HIT family signature motif; other site 703339005681 catalytic residue [active] 703339005682 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 703339005683 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 703339005684 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 703339005685 SurA N-terminal domain; Region: SurA_N_3; cl07813 703339005686 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 703339005687 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 703339005688 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 703339005689 generic binding surface II; other site 703339005690 generic binding surface I; other site 703339005691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 703339005692 Zn2+ binding site [ion binding]; other site 703339005693 Mg2+ binding site [ion binding]; other site 703339005694 Uncharacterized conserved protein [Function unknown]; Region: COG4717 703339005695 P-loop containing region of AAA domain; Region: AAA_29; cl17516 703339005696 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 703339005697 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 703339005698 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 703339005699 active site 703339005700 metal binding site [ion binding]; metal-binding site 703339005701 DNA binding site [nucleotide binding] 703339005702 hypothetical protein; Provisional; Region: PRK13676 703339005703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 703339005704 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 703339005705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339005706 non-specific DNA binding site [nucleotide binding]; other site 703339005707 salt bridge; other site 703339005708 sequence-specific DNA binding site [nucleotide binding]; other site 703339005709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 703339005710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339005711 active site 703339005712 phosphorylation site [posttranslational modification] 703339005713 intermolecular recognition site; other site 703339005714 dimerization interface [polypeptide binding]; other site 703339005715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 703339005716 DNA binding residues [nucleotide binding] 703339005717 dimerization interface [polypeptide binding]; other site 703339005718 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 703339005719 GAF domain; Region: GAF_3; pfam13492 703339005720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 703339005721 Histidine kinase; Region: HisKA_3; pfam07730 703339005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339005723 ATP binding site [chemical binding]; other site 703339005724 Mg2+ binding site [ion binding]; other site 703339005725 G-X-G motif; other site 703339005726 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 703339005727 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 703339005728 active site 703339005729 fumarate hydratase; Reviewed; Region: fumC; PRK00485 703339005730 Class II fumarases; Region: Fumarase_classII; cd01362 703339005731 active site 703339005732 tetramer interface [polypeptide binding]; other site 703339005733 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 703339005734 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 703339005735 active site 703339005736 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 703339005737 epoxyqueuosine reductase; Region: TIGR00276 703339005738 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 703339005739 HEAT repeats; Region: HEAT_2; pfam13646 703339005740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 703339005741 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 703339005742 Walker A/P-loop; other site 703339005743 ATP binding site [chemical binding]; other site 703339005744 Q-loop/lid; other site 703339005745 ABC transporter signature motif; other site 703339005746 Walker B; other site 703339005747 D-loop; other site 703339005748 H-loop/switch region; other site 703339005749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 703339005750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 703339005751 substrate binding pocket [chemical binding]; other site 703339005752 membrane-bound complex binding site; other site 703339005753 hinge residues; other site 703339005754 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 703339005755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339005756 dimer interface [polypeptide binding]; other site 703339005757 conserved gate region; other site 703339005758 putative PBP binding loops; other site 703339005759 ABC-ATPase subunit interface; other site 703339005760 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 703339005761 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 703339005762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 703339005763 Transposase; Region: DDE_Tnp_ISL3; pfam01610 703339005764 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 703339005765 metal binding site 2 [ion binding]; metal-binding site 703339005766 putative DNA binding helix; other site 703339005767 metal binding site 1 [ion binding]; metal-binding site 703339005768 dimer interface [polypeptide binding]; other site 703339005769 structural Zn2+ binding site [ion binding]; other site 703339005770 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 703339005771 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 703339005772 putative ligand binding site [chemical binding]; other site 703339005773 NAD binding site [chemical binding]; other site 703339005774 catalytic site [active] 703339005775 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 703339005776 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 703339005777 catalytic triad [active] 703339005778 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 703339005779 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 703339005780 inhibitor-cofactor binding pocket; inhibition site 703339005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339005782 catalytic residue [active] 703339005783 Predicted membrane protein [Function unknown]; Region: COG4129 703339005784 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 703339005785 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 703339005786 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 703339005787 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 703339005788 Walker A/P-loop; other site 703339005789 ATP binding site [chemical binding]; other site 703339005790 Q-loop/lid; other site 703339005791 ABC transporter signature motif; other site 703339005792 Walker B; other site 703339005793 D-loop; other site 703339005794 H-loop/switch region; other site 703339005795 hypothetical protein; Provisional; Region: PRK13662 703339005796 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 703339005797 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 703339005798 minor groove reading motif; other site 703339005799 helix-hairpin-helix signature motif; other site 703339005800 substrate binding pocket [chemical binding]; other site 703339005801 active site 703339005802 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 703339005803 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 703339005804 DNA binding and oxoG recognition site [nucleotide binding] 703339005805 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 703339005806 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 703339005807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339005808 Walker A/P-loop; other site 703339005809 ATP binding site [chemical binding]; other site 703339005810 Q-loop/lid; other site 703339005811 ABC transporter signature motif; other site 703339005812 Walker B; other site 703339005813 H-loop/switch region; other site 703339005814 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 703339005815 recombination regulator RecX; Provisional; Region: recX; PRK14135 703339005816 glycosyltransferase; Provisional; Region: PRK13481 703339005817 Transglycosylase; Region: Transgly; pfam00912 703339005818 intracellular protease, PfpI family; Region: PfpI; TIGR01382 703339005819 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 703339005820 proposed catalytic triad [active] 703339005821 conserved cys residue [active] 703339005822 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 703339005823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339005824 FeS/SAM binding site; other site 703339005825 YfkB-like domain; Region: YfkB; pfam08756 703339005826 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 703339005827 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 703339005828 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 703339005829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 703339005830 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 703339005831 Low molecular weight phosphatase family; Region: LMWPc; cd00115 703339005832 active site 703339005833 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 703339005834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 703339005835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339005836 active site 703339005837 phosphorylation site [posttranslational modification] 703339005838 intermolecular recognition site; other site 703339005839 dimerization interface [polypeptide binding]; other site 703339005840 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 703339005841 DNA binding residues [nucleotide binding] 703339005842 dimerization interface [polypeptide binding]; other site 703339005843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 703339005844 Histidine kinase; Region: HisKA_3; pfam07730 703339005845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339005846 ATP binding site [chemical binding]; other site 703339005847 Mg2+ binding site [ion binding]; other site 703339005848 G-X-G motif; other site 703339005849 Predicted membrane protein [Function unknown]; Region: COG4758 703339005850 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 703339005851 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 703339005852 active site 703339005853 Predicted membrane protein [Function unknown]; Region: COG4129 703339005854 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 703339005855 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 703339005856 catalytic triad [active] 703339005857 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 703339005858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 703339005859 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 703339005860 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 703339005861 Ferritin-like domain; Region: Ferritin; pfam00210 703339005862 ferroxidase diiron center [ion binding]; other site 703339005863 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 703339005864 active site 703339005865 catalytic site [active] 703339005866 substrate binding site [chemical binding]; other site 703339005867 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 703339005868 active site 703339005869 DNA polymerase IV; Validated; Region: PRK02406 703339005870 DNA binding site [nucleotide binding] 703339005871 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 703339005872 TRAM domain; Region: TRAM; cl01282 703339005873 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 703339005874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339005875 S-adenosylmethionine binding site [chemical binding]; other site 703339005876 putative lipid kinase; Reviewed; Region: PRK13337 703339005877 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 703339005878 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 703339005879 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 703339005880 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 703339005881 GatB domain; Region: GatB_Yqey; pfam02637 703339005882 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 703339005883 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 703339005884 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 703339005885 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 703339005886 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 703339005887 Na binding site [ion binding]; other site 703339005888 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 703339005889 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 703339005890 putative dimer interface [polypeptide binding]; other site 703339005891 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 703339005892 putative dimer interface [polypeptide binding]; other site 703339005893 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 703339005894 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 703339005895 nucleotide binding pocket [chemical binding]; other site 703339005896 K-X-D-G motif; other site 703339005897 catalytic site [active] 703339005898 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 703339005899 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 703339005900 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 703339005901 Dimer interface [polypeptide binding]; other site 703339005902 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 703339005903 Part of AAA domain; Region: AAA_19; pfam13245 703339005904 Family description; Region: UvrD_C_2; pfam13538 703339005905 PcrB family; Region: PcrB; pfam01884 703339005906 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 703339005907 substrate binding site [chemical binding]; other site 703339005908 putative active site [active] 703339005909 dimer interface [polypeptide binding]; other site 703339005910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 703339005911 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 703339005912 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 703339005913 tetramer interface [polypeptide binding]; other site 703339005914 active site 703339005915 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 703339005916 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 703339005917 Staphostatin A; Region: Staphostatin_A; pfam09022 703339005918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 703339005919 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 703339005920 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 703339005921 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 703339005922 homodimer interface [polypeptide binding]; other site 703339005923 NAD binding pocket [chemical binding]; other site 703339005924 ATP binding pocket [chemical binding]; other site 703339005925 Mg binding site [ion binding]; other site 703339005926 active-site loop [active] 703339005927 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 703339005928 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 703339005929 active site 703339005930 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 703339005931 active site 703339005932 dimer interface [polypeptide binding]; other site 703339005933 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 703339005934 Prephenate dehydratase; Region: PDT; pfam00800 703339005935 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 703339005936 putative L-Phe binding site [chemical binding]; other site 703339005937 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 703339005938 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 703339005939 transmembrane helices; other site 703339005940 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 703339005941 Isochorismatase family; Region: Isochorismatase; pfam00857 703339005942 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 703339005943 catalytic triad [active] 703339005944 conserved cis-peptide bond; other site 703339005945 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 703339005946 DHH family; Region: DHH; pfam01368 703339005947 DHHA2 domain; Region: DHHA2; pfam02833 703339005948 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 703339005949 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 703339005950 NAD(P) binding site [chemical binding]; other site 703339005951 catalytic residues [active] 703339005952 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 703339005953 YolD-like protein; Region: YolD; pfam08863 703339005954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 703339005955 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 703339005956 active site 703339005957 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 703339005958 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 703339005959 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 703339005960 Bacterial PH domain; Region: DUF304; cl01348 703339005961 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 703339005962 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 703339005963 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339005964 Walker A/P-loop; other site 703339005965 ATP binding site [chemical binding]; other site 703339005966 Q-loop/lid; other site 703339005967 ABC transporter signature motif; other site 703339005968 Walker B; other site 703339005969 D-loop; other site 703339005970 H-loop/switch region; other site 703339005971 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 703339005972 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 703339005973 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 703339005974 Walker A/P-loop; other site 703339005975 ATP binding site [chemical binding]; other site 703339005976 Q-loop/lid; other site 703339005977 ABC transporter signature motif; other site 703339005978 Walker B; other site 703339005979 D-loop; other site 703339005980 H-loop/switch region; other site 703339005981 Predicted transcriptional regulators [Transcription]; Region: COG1725 703339005982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339005983 DNA-binding site [nucleotide binding]; DNA binding site 703339005984 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 703339005985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339005986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339005987 homodimer interface [polypeptide binding]; other site 703339005988 catalytic residue [active] 703339005989 MAP domain; Region: MAP; pfam03642 703339005990 MAP domain; Region: MAP; pfam03642 703339005991 MAP domain; Region: MAP; pfam03642 703339005992 MAP domain; Region: MAP; pfam03642 703339005993 MAP domain; Region: MAP; pfam03642 703339005994 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 703339005995 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 703339005996 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 703339005997 Bacterial SH3 domain homologues; Region: SH3b; smart00287 703339005998 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 703339005999 CHAP domain; Region: CHAP; pfam05257 703339006000 Small integral membrane protein [Function unknown]; Region: COG5546 703339006001 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 703339006002 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 703339006003 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 703339006004 Ligand-gated ion channel; Region: Lig_chan; pfam00060 703339006005 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 703339006006 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 703339006007 Phage tail protein; Region: Sipho_tail; cl17486 703339006008 Phage tail protein; Region: Sipho_tail; cl17486 703339006009 Phage-related minor tail protein [Function unknown]; Region: COG5280 703339006010 Phage-related protein [Function unknown]; Region: COG5412 703339006011 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 703339006012 Peptidase family M23; Region: Peptidase_M23; pfam01551 703339006013 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 703339006014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 703339006015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 703339006016 catalytic residue [active] 703339006017 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 703339006018 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 703339006019 Translocation protein Sec62; Region: Sec62; cl02170 703339006020 Phage capsid family; Region: Phage_capsid; pfam05065 703339006021 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 703339006022 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 703339006023 oligomer interface [polypeptide binding]; other site 703339006024 active site residues [active] 703339006025 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 703339006026 Phage-related protein [Function unknown]; Region: COG4695; cl01923 703339006027 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 703339006028 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 703339006029 HNH endonuclease; Region: HNH; pfam01844 703339006030 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 703339006031 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 703339006032 Transcriptional activator RinB; Region: RinB; pfam06116 703339006033 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 703339006034 dUTPase; Region: dUTPase_2; pfam08761 703339006035 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 703339006036 active site 703339006037 homodimer interface [polypeptide binding]; other site 703339006038 metal binding site [ion binding]; metal-binding site 703339006039 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 703339006040 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 703339006041 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 703339006042 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 703339006043 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 703339006044 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 703339006045 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 703339006046 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 703339006047 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 703339006048 dimer interface [polypeptide binding]; other site 703339006049 ssDNA binding site [nucleotide binding]; other site 703339006050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339006051 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 703339006052 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 703339006053 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 703339006054 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 703339006055 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 703339006056 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 703339006057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 703339006058 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 703339006059 Phage anti-repressor protein [Transcription]; Region: COG3561 703339006060 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 703339006061 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 703339006062 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 703339006063 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 703339006064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339006065 non-specific DNA binding site [nucleotide binding]; other site 703339006066 salt bridge; other site 703339006067 sequence-specific DNA binding site [nucleotide binding]; other site 703339006068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339006069 non-specific DNA binding site [nucleotide binding]; other site 703339006070 salt bridge; other site 703339006071 sequence-specific DNA binding site [nucleotide binding]; other site 703339006072 Predicted transcriptional regulator [Transcription]; Region: COG2932 703339006073 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 703339006074 Catalytic site [active] 703339006075 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 703339006076 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 703339006077 active site 703339006078 catalytic site [active] 703339006079 substrate binding site [chemical binding]; other site 703339006080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 703339006081 active site 703339006082 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 703339006083 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 703339006084 Int/Topo IB signature motif; other site 703339006085 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 703339006086 putative catalytic site [active] 703339006087 phosphate binding site [ion binding]; other site 703339006088 metal binding site A [ion binding]; metal-binding site 703339006089 metal binding site C [ion binding]; metal-binding site 703339006090 metal binding site B [ion binding]; metal-binding site 703339006091 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 703339006092 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 703339006093 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 703339006094 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 703339006095 metal binding site [ion binding]; metal-binding site 703339006096 dimer interface [polypeptide binding]; other site 703339006097 Cation transport protein; Region: TrkH; cl17365 703339006098 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 703339006099 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 703339006100 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 703339006101 ring oligomerisation interface [polypeptide binding]; other site 703339006102 ATP/Mg binding site [chemical binding]; other site 703339006103 stacking interactions; other site 703339006104 hinge regions; other site 703339006105 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 703339006106 oligomerisation interface [polypeptide binding]; other site 703339006107 mobile loop; other site 703339006108 roof hairpin; other site 703339006109 CAAX protease self-immunity; Region: Abi; pfam02517 703339006110 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 703339006111 dimer interface [polypeptide binding]; other site 703339006112 FMN binding site [chemical binding]; other site 703339006113 Predicted amidohydrolase [General function prediction only]; Region: COG0388 703339006114 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 703339006115 putative active site [active] 703339006116 catalytic triad [active] 703339006117 putative dimer interface [polypeptide binding]; other site 703339006118 delta-hemolysin; Provisional; Region: PRK14752 703339006119 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 703339006120 Staphylococcal AgrD protein; Region: AgrD; pfam05931 703339006121 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 703339006122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339006123 Mg2+ binding site [ion binding]; other site 703339006124 G-X-G motif; other site 703339006125 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 703339006126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339006127 active site 703339006128 phosphorylation site [posttranslational modification] 703339006129 intermolecular recognition site; other site 703339006130 dimerization interface [polypeptide binding]; other site 703339006131 LytTr DNA-binding domain; Region: LytTR; pfam04397 703339006132 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 703339006133 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 703339006134 putative substrate binding site [chemical binding]; other site 703339006135 putative ATP binding site [chemical binding]; other site 703339006136 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 703339006137 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 703339006138 substrate binding [chemical binding]; other site 703339006139 active site 703339006140 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 703339006141 Transcriptional regulators [Transcription]; Region: PurR; COG1609 703339006142 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 703339006143 DNA binding site [nucleotide binding] 703339006144 domain linker motif; other site 703339006145 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 703339006146 dimerization interface [polypeptide binding]; other site 703339006147 ligand binding site [chemical binding]; other site 703339006148 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 703339006149 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 703339006150 CPxP motif; other site 703339006151 Predicted transporter component [General function prediction only]; Region: COG2391 703339006152 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 703339006153 Sulphur transport; Region: Sulf_transp; pfam04143 703339006154 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 703339006155 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 703339006156 CoA binding domain; Region: CoA_binding; pfam02629 703339006157 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 703339006158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339006159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339006160 ABC transporter; Region: ABC_tran_2; pfam12848 703339006161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 703339006162 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 703339006163 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 703339006164 Walker A/P-loop; other site 703339006165 ATP binding site [chemical binding]; other site 703339006166 Q-loop/lid; other site 703339006167 ABC transporter signature motif; other site 703339006168 Walker B; other site 703339006169 D-loop; other site 703339006170 H-loop/switch region; other site 703339006171 UGMP family protein; Validated; Region: PRK09604 703339006172 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 703339006173 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 703339006174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339006175 Coenzyme A binding pocket [chemical binding]; other site 703339006176 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 703339006177 Glycoprotease family; Region: Peptidase_M22; pfam00814 703339006178 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 703339006179 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 703339006180 6-phosphogluconate dehydratase; Region: edd; TIGR01196 703339006181 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 703339006182 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 703339006183 PYR/PP interface [polypeptide binding]; other site 703339006184 dimer interface [polypeptide binding]; other site 703339006185 TPP binding site [chemical binding]; other site 703339006186 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 703339006187 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 703339006188 TPP-binding site [chemical binding]; other site 703339006189 dimer interface [polypeptide binding]; other site 703339006190 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 703339006191 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 703339006192 ketol-acid reductoisomerase; Provisional; Region: PRK05479 703339006193 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 703339006194 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 703339006195 2-isopropylmalate synthase; Validated; Region: PRK00915 703339006196 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 703339006197 active site 703339006198 catalytic residues [active] 703339006199 metal binding site [ion binding]; metal-binding site 703339006200 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 703339006201 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 703339006202 tartrate dehydrogenase; Region: TTC; TIGR02089 703339006203 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 703339006204 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 703339006205 substrate binding site [chemical binding]; other site 703339006206 ligand binding site [chemical binding]; other site 703339006207 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 703339006208 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 703339006209 substrate binding site [chemical binding]; other site 703339006210 threonine dehydratase; Validated; Region: PRK08639 703339006211 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 703339006212 tetramer interface [polypeptide binding]; other site 703339006213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339006214 catalytic residue [active] 703339006215 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 703339006216 putative Ile/Val binding site [chemical binding]; other site 703339006217 hypothetical protein; Provisional; Region: PRK04351 703339006218 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 703339006219 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 703339006220 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 703339006221 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 703339006222 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 703339006223 RNA binding site [nucleotide binding]; other site 703339006224 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 703339006225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 703339006226 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 703339006227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 703339006228 DNA binding residues [nucleotide binding] 703339006229 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 703339006230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339006231 ATP binding site [chemical binding]; other site 703339006232 Mg2+ binding site [ion binding]; other site 703339006233 G-X-G motif; other site 703339006234 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 703339006235 anti sigma factor interaction site; other site 703339006236 regulatory phosphorylation site [posttranslational modification]; other site 703339006237 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 703339006238 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 703339006239 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 703339006240 PemK-like protein; Region: PemK; pfam02452 703339006241 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 703339006242 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 703339006243 active site 703339006244 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 703339006245 dimer interface [polypeptide binding]; other site 703339006246 substrate binding site [chemical binding]; other site 703339006247 catalytic residues [active] 703339006248 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 703339006249 Uncharacterized conserved protein [Function unknown]; Region: COG3402 703339006250 Predicted membrane protein [Function unknown]; Region: COG3428 703339006251 Bacterial PH domain; Region: DUF304; pfam03703 703339006252 Bacterial PH domain; Region: DUF304; pfam03703 703339006253 Bacterial PH domain; Region: DUF304; cl01348 703339006254 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 703339006255 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 703339006256 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 703339006257 Soluble P-type ATPase [General function prediction only]; Region: COG4087 703339006258 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 703339006259 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 703339006260 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 703339006261 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 703339006262 Ligand Binding Site [chemical binding]; other site 703339006263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339006264 dimer interface [polypeptide binding]; other site 703339006265 phosphorylation site [posttranslational modification] 703339006266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339006267 ATP binding site [chemical binding]; other site 703339006268 Mg2+ binding site [ion binding]; other site 703339006269 G-X-G motif; other site 703339006270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339006271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339006272 active site 703339006273 phosphorylation site [posttranslational modification] 703339006274 intermolecular recognition site; other site 703339006275 dimerization interface [polypeptide binding]; other site 703339006276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339006277 DNA binding site [nucleotide binding] 703339006278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 703339006279 Transposase; Region: DDE_Tnp_ISL3; pfam01610 703339006280 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 703339006281 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 703339006282 ATP binding site [chemical binding]; other site 703339006283 Mg++ binding site [ion binding]; other site 703339006284 motif III; other site 703339006285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339006286 nucleotide binding region [chemical binding]; other site 703339006287 ATP-binding site [chemical binding]; other site 703339006288 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 703339006289 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 703339006290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 703339006291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 703339006292 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 703339006293 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 703339006294 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 703339006295 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 703339006296 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 703339006297 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 703339006298 putative homodimer interface [polypeptide binding]; other site 703339006299 putative homotetramer interface [polypeptide binding]; other site 703339006300 allosteric switch controlling residues; other site 703339006301 putative metal binding site [ion binding]; other site 703339006302 putative homodimer-homodimer interface [polypeptide binding]; other site 703339006303 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 703339006304 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 703339006305 putative active site [active] 703339006306 catalytic site [active] 703339006307 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 703339006308 putative active site [active] 703339006309 catalytic site [active] 703339006310 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 703339006311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 703339006312 Zn2+ binding site [ion binding]; other site 703339006313 Mg2+ binding site [ion binding]; other site 703339006314 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 703339006315 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 703339006316 thiamine phosphate binding site [chemical binding]; other site 703339006317 active site 703339006318 pyrophosphate binding site [ion binding]; other site 703339006319 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 703339006320 substrate binding site [chemical binding]; other site 703339006321 multimerization interface [polypeptide binding]; other site 703339006322 ATP binding site [chemical binding]; other site 703339006323 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 703339006324 dimer interface [polypeptide binding]; other site 703339006325 substrate binding site [chemical binding]; other site 703339006326 ATP binding site [chemical binding]; other site 703339006327 thiaminase II; Region: salvage_TenA; TIGR04306 703339006328 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 703339006329 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 703339006330 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 703339006331 dimer interface [polypeptide binding]; other site 703339006332 ssDNA binding site [nucleotide binding]; other site 703339006333 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339006334 YwpF-like protein; Region: YwpF; pfam14183 703339006335 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 703339006336 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 703339006337 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 703339006338 hinge; other site 703339006339 active site 703339006340 Predicted membrane protein [Function unknown]; Region: COG4836 703339006341 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 703339006342 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 703339006343 gamma subunit interface [polypeptide binding]; other site 703339006344 epsilon subunit interface [polypeptide binding]; other site 703339006345 LBP interface [polypeptide binding]; other site 703339006346 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 703339006347 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 703339006348 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 703339006349 alpha subunit interaction interface [polypeptide binding]; other site 703339006350 Walker A motif; other site 703339006351 ATP binding site [chemical binding]; other site 703339006352 Walker B motif; other site 703339006353 inhibitor binding site; inhibition site 703339006354 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 703339006355 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 703339006356 core domain interface [polypeptide binding]; other site 703339006357 delta subunit interface [polypeptide binding]; other site 703339006358 epsilon subunit interface [polypeptide binding]; other site 703339006359 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 703339006360 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 703339006361 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 703339006362 beta subunit interaction interface [polypeptide binding]; other site 703339006363 Walker A motif; other site 703339006364 ATP binding site [chemical binding]; other site 703339006365 Walker B motif; other site 703339006366 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 703339006367 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 703339006368 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 703339006369 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 703339006370 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 703339006371 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 703339006372 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 703339006373 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 703339006374 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 703339006375 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 703339006376 active site 703339006377 homodimer interface [polypeptide binding]; other site 703339006378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 703339006379 active site 703339006380 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 703339006381 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 703339006382 dimer interface [polypeptide binding]; other site 703339006383 active site 703339006384 glycine-pyridoxal phosphate binding site [chemical binding]; other site 703339006385 folate binding site [chemical binding]; other site 703339006386 hypothetical protein; Provisional; Region: PRK13690 703339006387 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 703339006388 Low molecular weight phosphatase family; Region: LMWPc; cd00115 703339006389 active site 703339006390 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 703339006391 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 703339006392 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 703339006393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339006394 S-adenosylmethionine binding site [chemical binding]; other site 703339006395 peptide chain release factor 1; Validated; Region: prfA; PRK00591 703339006396 This domain is found in peptide chain release factors; Region: PCRF; smart00937 703339006397 RF-1 domain; Region: RF-1; pfam00472 703339006398 thymidine kinase; Provisional; Region: PRK04296 703339006399 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 703339006400 transcription termination factor Rho; Provisional; Region: rho; PRK09376 703339006401 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 703339006402 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 703339006403 RNA binding site [nucleotide binding]; other site 703339006404 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 703339006405 multimer interface [polypeptide binding]; other site 703339006406 Walker A motif; other site 703339006407 ATP binding site [chemical binding]; other site 703339006408 Walker B motif; other site 703339006409 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 703339006410 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 703339006411 NAD binding site [chemical binding]; other site 703339006412 catalytic residues [active] 703339006413 Predicted transcriptional regulators [Transcription]; Region: COG1733 703339006414 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 703339006415 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 703339006416 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 703339006417 hinge; other site 703339006418 active site 703339006419 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 703339006420 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 703339006421 intersubunit interface [polypeptide binding]; other site 703339006422 active site 703339006423 zinc binding site [ion binding]; other site 703339006424 Na+ binding site [ion binding]; other site 703339006425 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 703339006426 CTP synthetase; Validated; Region: pyrG; PRK05380 703339006427 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 703339006428 Catalytic site [active] 703339006429 active site 703339006430 UTP binding site [chemical binding]; other site 703339006431 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 703339006432 active site 703339006433 putative oxyanion hole; other site 703339006434 catalytic triad [active] 703339006435 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 703339006436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339006437 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 703339006438 Coenzyme A binding pocket [chemical binding]; other site 703339006439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339006440 Coenzyme A binding pocket [chemical binding]; other site 703339006441 pantothenate kinase; Provisional; Region: PRK13317 703339006442 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 703339006443 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 703339006444 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 703339006445 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 703339006446 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 703339006447 metal binding site [ion binding]; metal-binding site 703339006448 S-ribosylhomocysteinase; Provisional; Region: PRK02260 703339006449 Predicted membrane protein [Function unknown]; Region: COG4270 703339006450 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 703339006451 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 703339006452 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 703339006453 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 703339006454 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 703339006455 intersubunit interface [polypeptide binding]; other site 703339006456 active site 703339006457 catalytic residue [active] 703339006458 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 703339006459 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 703339006460 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 703339006461 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 703339006462 dimerization interface [polypeptide binding]; other site 703339006463 DPS ferroxidase diiron center [ion binding]; other site 703339006464 ion pore; other site 703339006465 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 703339006466 EVE domain; Region: EVE; cl00728 703339006467 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 703339006468 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 703339006469 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 703339006470 NADH(P)-binding; Region: NAD_binding_10; pfam13460 703339006471 NAD(P) binding site [chemical binding]; other site 703339006472 putative active site [active] 703339006473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 703339006474 dimerization interface [polypeptide binding]; other site 703339006475 putative DNA binding site [nucleotide binding]; other site 703339006476 putative Zn2+ binding site [ion binding]; other site 703339006477 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 703339006478 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 703339006479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 703339006480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 703339006481 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 703339006482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339006483 active site 703339006484 motif I; other site 703339006485 motif II; other site 703339006486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339006487 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 703339006488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339006489 Walker A/P-loop; other site 703339006490 ATP binding site [chemical binding]; other site 703339006491 Q-loop/lid; other site 703339006492 ABC transporter signature motif; other site 703339006493 Walker B; other site 703339006494 D-loop; other site 703339006495 H-loop/switch region; other site 703339006496 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 703339006497 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 703339006498 glutaminase active site [active] 703339006499 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 703339006500 dimer interface [polypeptide binding]; other site 703339006501 active site 703339006502 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 703339006503 dimer interface [polypeptide binding]; other site 703339006504 active site 703339006505 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 703339006506 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 703339006507 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 703339006508 active site 703339006509 P-loop; other site 703339006510 phosphorylation site [posttranslational modification] 703339006511 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 703339006512 HTH domain; Region: HTH_11; pfam08279 703339006513 Mga helix-turn-helix domain; Region: Mga; pfam05043 703339006514 PRD domain; Region: PRD; pfam00874 703339006515 PRD domain; Region: PRD; pfam00874 703339006516 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 703339006517 active site 703339006518 P-loop; other site 703339006519 phosphorylation site [posttranslational modification] 703339006520 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 703339006521 active site 703339006522 phosphorylation site [posttranslational modification] 703339006523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339006524 active site 703339006525 phosphorylation site [posttranslational modification] 703339006526 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 703339006527 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 703339006528 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 703339006529 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339006530 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 703339006531 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006532 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006533 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006534 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006535 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006536 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006537 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 703339006538 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 703339006539 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 703339006540 active site 703339006541 substrate binding site [chemical binding]; other site 703339006542 metal binding site [ion binding]; metal-binding site 703339006543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 703339006544 YbbR-like protein; Region: YbbR; pfam07949 703339006545 TIGR00159 family protein; Region: TIGR00159 703339006546 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 703339006547 Arginase family; Region: Arginase; cd09989 703339006548 active site 703339006549 Mn binding site [ion binding]; other site 703339006550 oligomer interface [polypeptide binding]; other site 703339006551 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 703339006552 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 703339006553 Walker A motif; other site 703339006554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339006555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339006556 putative substrate translocation pore; other site 703339006557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339006558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339006559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339006560 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 703339006561 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 703339006562 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 703339006563 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 703339006564 substrate binding site; other site 703339006565 dimerization interface; other site 703339006566 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 703339006567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 703339006568 Nucleoside recognition; Region: Gate; pfam07670 703339006569 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 703339006570 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339006571 ABC-ATPase subunit interface; other site 703339006572 dimer interface [polypeptide binding]; other site 703339006573 putative PBP binding regions; other site 703339006574 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 703339006575 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 703339006576 ABC-ATPase subunit interface; other site 703339006577 dimer interface [polypeptide binding]; other site 703339006578 putative PBP binding regions; other site 703339006579 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 703339006580 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 703339006581 siderophore binding site; other site 703339006582 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 703339006583 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 703339006584 dimer interface [polypeptide binding]; other site 703339006585 active site 703339006586 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 703339006587 substrate binding site [chemical binding]; other site 703339006588 catalytic residue [active] 703339006589 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 703339006590 IucA / IucC family; Region: IucA_IucC; pfam04183 703339006591 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 703339006592 H+ Antiporter protein; Region: 2A0121; TIGR00900 703339006593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339006594 putative substrate translocation pore; other site 703339006595 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 703339006596 IucA / IucC family; Region: IucA_IucC; pfam04183 703339006597 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 703339006598 Asp23 family; Region: Asp23; pfam03780 703339006599 Small integral membrane protein [Function unknown]; Region: COG5547 703339006600 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 703339006601 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 703339006602 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 703339006603 putative NAD(P) binding site [chemical binding]; other site 703339006604 dimer interface [polypeptide binding]; other site 703339006605 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 703339006606 Prostaglandin dehydrogenases; Region: PGDH; cd05288 703339006607 NAD(P) binding site [chemical binding]; other site 703339006608 substrate binding site [chemical binding]; other site 703339006609 dimer interface [polypeptide binding]; other site 703339006610 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 703339006611 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 703339006612 beta-galactosidase; Region: BGL; TIGR03356 703339006613 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 703339006614 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 703339006615 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 703339006616 active site 703339006617 P-loop; other site 703339006618 phosphorylation site [posttranslational modification] 703339006619 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 703339006620 methionine cluster; other site 703339006621 active site 703339006622 phosphorylation site [posttranslational modification] 703339006623 metal binding site [ion binding]; metal-binding site 703339006624 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 703339006625 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 703339006626 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 703339006627 putative substrate binding site [chemical binding]; other site 703339006628 putative ATP binding site [chemical binding]; other site 703339006629 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 703339006630 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 703339006631 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 703339006632 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 703339006633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 703339006634 NAD-dependent deacetylase; Provisional; Region: PRK00481 703339006635 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 703339006636 NAD+ binding site [chemical binding]; other site 703339006637 substrate binding site [chemical binding]; other site 703339006638 putative Zn binding site [ion binding]; other site 703339006639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 703339006640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 703339006641 active site 703339006642 catalytic tetrad [active] 703339006643 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 703339006644 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 703339006645 DNA binding residues [nucleotide binding] 703339006646 putative dimer interface [polypeptide binding]; other site 703339006647 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 703339006648 substrate binding site [chemical binding]; other site 703339006649 catalytic residues [active] 703339006650 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 703339006651 Peptidase family M23; Region: Peptidase_M23; pfam01551 703339006652 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 703339006653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 703339006654 active site 703339006655 motif I; other site 703339006656 motif II; other site 703339006657 MAP domain; Region: MAP; pfam03642 703339006658 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 703339006659 acetolactate synthase; Reviewed; Region: PRK08617 703339006660 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 703339006661 PYR/PP interface [polypeptide binding]; other site 703339006662 dimer interface [polypeptide binding]; other site 703339006663 TPP binding site [chemical binding]; other site 703339006664 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 703339006665 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 703339006666 TPP-binding site [chemical binding]; other site 703339006667 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 703339006668 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 703339006669 putative active site [active] 703339006670 putative NTP binding site [chemical binding]; other site 703339006671 putative nucleic acid binding site [nucleotide binding]; other site 703339006672 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 703339006673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 703339006674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 703339006675 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 703339006676 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 703339006677 23S rRNA interface [nucleotide binding]; other site 703339006678 L3 interface [polypeptide binding]; other site 703339006679 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 703339006680 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 703339006681 dimerization interface 3.5A [polypeptide binding]; other site 703339006682 active site 703339006683 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 703339006684 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 703339006685 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 703339006686 Walker A/P-loop; other site 703339006687 ATP binding site [chemical binding]; other site 703339006688 Q-loop/lid; other site 703339006689 ABC transporter signature motif; other site 703339006690 Walker B; other site 703339006691 D-loop; other site 703339006692 H-loop/switch region; other site 703339006693 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 703339006694 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 703339006695 Walker A/P-loop; other site 703339006696 ATP binding site [chemical binding]; other site 703339006697 Q-loop/lid; other site 703339006698 ABC transporter signature motif; other site 703339006699 Walker B; other site 703339006700 D-loop; other site 703339006701 H-loop/switch region; other site 703339006702 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 703339006703 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 703339006704 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 703339006705 alphaNTD homodimer interface [polypeptide binding]; other site 703339006706 alphaNTD - beta interaction site [polypeptide binding]; other site 703339006707 alphaNTD - beta' interaction site [polypeptide binding]; other site 703339006708 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 703339006709 30S ribosomal protein S11; Validated; Region: PRK05309 703339006710 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 703339006711 30S ribosomal protein S13; Region: bact_S13; TIGR03631 703339006712 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 703339006713 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 703339006714 rRNA binding site [nucleotide binding]; other site 703339006715 predicted 30S ribosome binding site; other site 703339006716 adenylate kinase; Reviewed; Region: adk; PRK00279 703339006717 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 703339006718 AMP-binding site [chemical binding]; other site 703339006719 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 703339006720 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 703339006721 SecY translocase; Region: SecY; pfam00344 703339006722 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 703339006723 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 703339006724 23S rRNA binding site [nucleotide binding]; other site 703339006725 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 703339006726 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 703339006727 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 703339006728 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 703339006729 5S rRNA interface [nucleotide binding]; other site 703339006730 L27 interface [polypeptide binding]; other site 703339006731 23S rRNA interface [nucleotide binding]; other site 703339006732 L5 interface [polypeptide binding]; other site 703339006733 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 703339006734 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 703339006735 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 703339006736 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 703339006737 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 703339006738 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 703339006739 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 703339006740 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 703339006741 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 703339006742 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 703339006743 RNA binding site [nucleotide binding]; other site 703339006744 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 703339006745 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 703339006746 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 703339006747 23S rRNA interface [nucleotide binding]; other site 703339006748 putative translocon interaction site; other site 703339006749 signal recognition particle (SRP54) interaction site; other site 703339006750 L23 interface [polypeptide binding]; other site 703339006751 trigger factor interaction site; other site 703339006752 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 703339006753 23S rRNA interface [nucleotide binding]; other site 703339006754 5S rRNA interface [nucleotide binding]; other site 703339006755 putative antibiotic binding site [chemical binding]; other site 703339006756 L25 interface [polypeptide binding]; other site 703339006757 L27 interface [polypeptide binding]; other site 703339006758 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 703339006759 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 703339006760 G-X-X-G motif; other site 703339006761 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 703339006762 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 703339006763 putative translocon binding site; other site 703339006764 protein-rRNA interface [nucleotide binding]; other site 703339006765 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 703339006766 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 703339006767 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 703339006768 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 703339006769 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 703339006770 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 703339006771 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 703339006772 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 703339006773 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 703339006774 DNA topoisomerase III; Provisional; Region: PRK07726 703339006775 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 703339006776 active site 703339006777 putative interdomain interaction site [polypeptide binding]; other site 703339006778 putative metal-binding site [ion binding]; other site 703339006779 putative nucleotide binding site [chemical binding]; other site 703339006780 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 703339006781 domain I; other site 703339006782 DNA binding groove [nucleotide binding] 703339006783 phosphate binding site [ion binding]; other site 703339006784 domain II; other site 703339006785 domain III; other site 703339006786 nucleotide binding site [chemical binding]; other site 703339006787 catalytic site [active] 703339006788 domain IV; other site 703339006789 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 703339006790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339006791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 703339006792 Coenzyme A binding pocket [chemical binding]; other site 703339006793 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 703339006794 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 703339006795 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339006796 Predicted permeases [General function prediction only]; Region: COG0679 703339006797 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 703339006798 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 703339006799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 703339006800 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 703339006801 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 703339006802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339006803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339006804 putative substrate translocation pore; other site 703339006805 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339006806 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339006807 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 703339006808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339006809 FeS/SAM binding site; other site 703339006810 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 703339006811 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 703339006812 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 703339006813 GTP binding site; other site 703339006814 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 703339006815 MoaE interaction surface [polypeptide binding]; other site 703339006816 MoeB interaction surface [polypeptide binding]; other site 703339006817 thiocarboxylated glycine; other site 703339006818 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 703339006819 MoaE homodimer interface [polypeptide binding]; other site 703339006820 MoaD interaction [polypeptide binding]; other site 703339006821 active site residues [active] 703339006822 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 703339006823 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 703339006824 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 703339006825 dimer interface [polypeptide binding]; other site 703339006826 putative functional site; other site 703339006827 putative MPT binding site; other site 703339006828 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 703339006829 trimer interface [polypeptide binding]; other site 703339006830 dimer interface [polypeptide binding]; other site 703339006831 putative active site [active] 703339006832 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 703339006833 MPT binding site; other site 703339006834 trimer interface [polypeptide binding]; other site 703339006835 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 703339006836 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 703339006837 ATP binding site [chemical binding]; other site 703339006838 substrate interface [chemical binding]; other site 703339006839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339006840 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 703339006841 Walker A/P-loop; other site 703339006842 ATP binding site [chemical binding]; other site 703339006843 Q-loop/lid; other site 703339006844 ABC transporter signature motif; other site 703339006845 Walker B; other site 703339006846 D-loop; other site 703339006847 H-loop/switch region; other site 703339006848 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 703339006849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339006850 dimer interface [polypeptide binding]; other site 703339006851 conserved gate region; other site 703339006852 putative PBP binding loops; other site 703339006853 ABC-ATPase subunit interface; other site 703339006854 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 703339006855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 703339006856 substrate binding pocket [chemical binding]; other site 703339006857 membrane-bound complex binding site; other site 703339006858 hinge residues; other site 703339006859 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 703339006860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339006861 Coenzyme A binding pocket [chemical binding]; other site 703339006862 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 703339006863 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 703339006864 active site 703339006865 dimerization interface [polypeptide binding]; other site 703339006866 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 703339006867 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 703339006868 intersubunit interface [polypeptide binding]; other site 703339006869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 703339006870 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 703339006871 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 703339006872 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 703339006873 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 703339006874 alpha-gamma subunit interface [polypeptide binding]; other site 703339006875 beta-gamma subunit interface [polypeptide binding]; other site 703339006876 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 703339006877 gamma-beta subunit interface [polypeptide binding]; other site 703339006878 alpha-beta subunit interface [polypeptide binding]; other site 703339006879 urease subunit alpha; Reviewed; Region: ureC; PRK13207 703339006880 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 703339006881 subunit interactions [polypeptide binding]; other site 703339006882 active site 703339006883 flap region; other site 703339006884 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 703339006885 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 703339006886 dimer interface [polypeptide binding]; other site 703339006887 catalytic residues [active] 703339006888 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 703339006889 UreF; Region: UreF; pfam01730 703339006890 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 703339006891 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 703339006892 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339006893 MarR family; Region: MarR_2; cl17246 703339006894 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339006895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339006896 Helix-turn-helix domain; Region: HTH_18; pfam12833 703339006897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 703339006898 Surface antigen [General function prediction only]; Region: COG3942 703339006899 CHAP domain; Region: CHAP; pfam05257 703339006900 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 703339006901 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 703339006902 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 703339006903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 703339006904 Surface antigen [General function prediction only]; Region: COG3942 703339006905 CHAP domain; Region: CHAP; pfam05257 703339006906 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 703339006907 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 703339006908 putative ligand binding site [chemical binding]; other site 703339006909 putative NAD binding site [chemical binding]; other site 703339006910 catalytic site [active] 703339006911 hypothetical protein; Provisional; Region: PRK06753 703339006912 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 703339006913 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 703339006914 Lysozyme subfamily 2; Region: LYZ2; smart00047 703339006915 Uncharacterized conserved protein [Function unknown]; Region: COG2427 703339006916 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 703339006917 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 703339006918 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 703339006919 4Fe-4S binding domain; Region: Fer4; pfam00037 703339006920 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 703339006921 [4Fe-4S] binding site [ion binding]; other site 703339006922 molybdopterin cofactor binding site; other site 703339006923 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 703339006924 molybdopterin cofactor binding site; other site 703339006925 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 703339006926 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 703339006927 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 703339006928 active site 703339006929 Predicted transcriptional regulator [Transcription]; Region: COG2378 703339006930 HTH domain; Region: HTH_11; pfam08279 703339006931 CAAX protease self-immunity; Region: Abi; pfam02517 703339006932 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 703339006933 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 703339006934 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 703339006935 putative active site [active] 703339006936 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 703339006937 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 703339006938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339006939 active site 703339006940 motif I; other site 703339006941 motif II; other site 703339006942 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 703339006943 Sodium Bile acid symporter family; Region: SBF; pfam01758 703339006944 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 703339006945 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339006946 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339006947 active site turn [active] 703339006948 phosphorylation site [posttranslational modification] 703339006949 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 703339006950 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 703339006951 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 703339006952 putative active site [active] 703339006953 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 703339006954 putative hydrophobic ligand binding site [chemical binding]; other site 703339006955 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 703339006956 oxidoreductase; Provisional; Region: PRK07985 703339006957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339006958 NAD(P) binding site [chemical binding]; other site 703339006959 active site 703339006960 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 703339006961 amidohydrolase; Region: amidohydrolases; TIGR01891 703339006962 metal binding site [ion binding]; metal-binding site 703339006963 dimer interface [polypeptide binding]; other site 703339006964 imidazolonepropionase; Validated; Region: PRK09356 703339006965 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 703339006966 active site 703339006967 urocanate hydratase; Provisional; Region: PRK05414 703339006968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 703339006969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 703339006970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 703339006971 dimerization interface [polypeptide binding]; other site 703339006972 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 703339006973 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 703339006974 putative active site [active] 703339006975 putative Mg binding site [ion binding]; other site 703339006976 formimidoylglutamase; Provisional; Region: PRK13775 703339006977 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 703339006978 putative active site [active] 703339006979 putative metal binding site [ion binding]; other site 703339006980 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 703339006981 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 703339006982 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339006983 active site 703339006984 dimer interface [polypeptide binding]; other site 703339006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 703339006986 MOSC domain; Region: MOSC; pfam03473 703339006987 3-alpha domain; Region: 3-alpha; pfam03475 703339006988 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 703339006989 active site 703339006990 catalytic residues [active] 703339006991 Uncharacterized conserved protein [Function unknown]; Region: COG1742 703339006992 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 703339006993 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 703339006994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339006995 Walker A/P-loop; other site 703339006996 ATP binding site [chemical binding]; other site 703339006997 Q-loop/lid; other site 703339006998 ABC transporter signature motif; other site 703339006999 Walker B; other site 703339007000 D-loop; other site 703339007001 H-loop/switch region; other site 703339007002 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 703339007003 Predicted membrane protein [Function unknown]; Region: COG3152 703339007004 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 703339007005 active site 703339007006 DNA binding site [nucleotide binding] 703339007007 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 703339007008 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 703339007009 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 703339007010 homotetramer interface [polypeptide binding]; other site 703339007011 FMN binding site [chemical binding]; other site 703339007012 homodimer contacts [polypeptide binding]; other site 703339007013 putative active site [active] 703339007014 putative substrate binding site [chemical binding]; other site 703339007015 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 703339007016 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 703339007017 oligomer interface [polypeptide binding]; other site 703339007018 metal binding site [ion binding]; metal-binding site 703339007019 metal binding site [ion binding]; metal-binding site 703339007020 putative Cl binding site [ion binding]; other site 703339007021 aspartate ring; other site 703339007022 basic sphincter; other site 703339007023 hydrophobic gate; other site 703339007024 periplasmic entrance; other site 703339007025 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 703339007026 active site 703339007027 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 703339007028 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 703339007029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007030 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 703339007031 putative substrate translocation pore; other site 703339007032 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 703339007033 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 703339007034 HlyD family secretion protein; Region: HlyD_3; pfam13437 703339007035 lipoyl-biotinyl attachment site [posttranslational modification]; other site 703339007036 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 703339007037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007038 putative substrate translocation pore; other site 703339007039 Predicted membrane protein [Function unknown]; Region: COG4640 703339007040 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 703339007041 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339007042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 703339007043 putative Zn2+ binding site [ion binding]; other site 703339007044 putative DNA binding site [nucleotide binding]; other site 703339007045 Uncharacterized conserved protein [Function unknown]; Region: COG1434 703339007046 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 703339007047 putative active site [active] 703339007048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 703339007049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339007050 Walker A/P-loop; other site 703339007051 ATP binding site [chemical binding]; other site 703339007052 Q-loop/lid; other site 703339007053 ABC transporter signature motif; other site 703339007054 Walker B; other site 703339007055 D-loop; other site 703339007056 H-loop/switch region; other site 703339007057 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 703339007058 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 703339007059 FtsX-like permease family; Region: FtsX; pfam02687 703339007060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339007061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339007062 active site 703339007063 phosphorylation site [posttranslational modification] 703339007064 intermolecular recognition site; other site 703339007065 dimerization interface [polypeptide binding]; other site 703339007066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339007067 DNA binding site [nucleotide binding] 703339007068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 703339007069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 703339007070 dimerization interface [polypeptide binding]; other site 703339007071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 703339007072 dimer interface [polypeptide binding]; other site 703339007073 phosphorylation site [posttranslational modification] 703339007074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339007075 ATP binding site [chemical binding]; other site 703339007076 Mg2+ binding site [ion binding]; other site 703339007077 G-X-G motif; other site 703339007078 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 703339007079 LytTr DNA-binding domain; Region: LytTR; smart00850 703339007080 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 703339007081 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 703339007082 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 703339007083 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 703339007084 L-lactate permease; Region: Lactate_perm; cl00701 703339007085 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 703339007086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339007087 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 703339007088 Coenzyme A binding pocket [chemical binding]; other site 703339007089 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 703339007090 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 703339007091 NAD(P) binding site [chemical binding]; other site 703339007092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339007093 Coenzyme A binding pocket [chemical binding]; other site 703339007094 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 703339007095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 703339007096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339007097 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 703339007098 Predicted membrane protein [Function unknown]; Region: COG1511 703339007099 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 703339007100 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 703339007101 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 703339007102 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 703339007103 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 703339007104 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 703339007105 Cl binding site [ion binding]; other site 703339007106 oligomer interface [polypeptide binding]; other site 703339007107 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 703339007108 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339007109 active site turn [active] 703339007110 phosphorylation site [posttranslational modification] 703339007111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339007112 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 703339007113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 703339007114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 703339007115 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 703339007116 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 703339007117 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 703339007118 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 703339007119 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 703339007120 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339007121 MarR family; Region: MarR_2; pfam12802 703339007122 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 703339007123 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 703339007124 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 703339007125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007126 putative substrate translocation pore; other site 703339007127 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 703339007128 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 703339007129 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 703339007130 DNA binding residues [nucleotide binding] 703339007131 dimer interface [polypeptide binding]; other site 703339007132 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 703339007133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 703339007134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339007135 active site 703339007136 phosphorylation site [posttranslational modification] 703339007137 intermolecular recognition site; other site 703339007138 dimerization interface [polypeptide binding]; other site 703339007139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 703339007140 DNA binding residues [nucleotide binding] 703339007141 dimerization interface [polypeptide binding]; other site 703339007142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 703339007143 Histidine kinase; Region: HisKA_3; pfam07730 703339007144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339007145 ATP binding site [chemical binding]; other site 703339007146 Mg2+ binding site [ion binding]; other site 703339007147 G-X-G motif; other site 703339007148 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 703339007149 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 703339007150 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 703339007151 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 703339007152 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 703339007153 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 703339007154 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 703339007155 [4Fe-4S] binding site [ion binding]; other site 703339007156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 703339007157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 703339007158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 703339007159 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 703339007160 molybdopterin cofactor binding site; other site 703339007161 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 703339007162 active site 703339007163 SAM binding site [chemical binding]; other site 703339007164 homodimer interface [polypeptide binding]; other site 703339007165 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 703339007166 [2Fe-2S] cluster binding site [ion binding]; other site 703339007167 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 703339007168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 703339007169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 703339007170 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 703339007171 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 703339007172 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 703339007173 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 703339007174 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 703339007175 putative active site [active] 703339007176 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 703339007177 active site 703339007178 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 703339007179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339007180 Coenzyme A binding pocket [chemical binding]; other site 703339007181 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 703339007182 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 703339007183 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 703339007184 putative hydrophobic ligand binding site [chemical binding]; other site 703339007185 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 703339007186 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 703339007187 intersubunit interface [polypeptide binding]; other site 703339007188 YodA lipocalin-like domain; Region: YodA; pfam09223 703339007189 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 703339007190 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 703339007191 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 703339007192 Thioredoxin; Region: Thioredoxin_4; cl17273 703339007193 FemAB family; Region: FemAB; pfam02388 703339007194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 703339007195 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 703339007196 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 703339007197 Walker A/P-loop; other site 703339007198 ATP binding site [chemical binding]; other site 703339007199 Q-loop/lid; other site 703339007200 ABC transporter signature motif; other site 703339007201 Walker B; other site 703339007202 D-loop; other site 703339007203 H-loop/switch region; other site 703339007204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 703339007205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339007206 putative PBP binding loops; other site 703339007207 dimer interface [polypeptide binding]; other site 703339007208 ABC-ATPase subunit interface; other site 703339007209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 703339007210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 703339007211 substrate binding pocket [chemical binding]; other site 703339007212 membrane-bound complex binding site; other site 703339007213 hinge residues; other site 703339007214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339007216 putative substrate translocation pore; other site 703339007217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007218 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 703339007219 catalytic core [active] 703339007220 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 703339007221 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 703339007222 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 703339007223 B domain; Region: B; pfam02216 703339007224 B domain; Region: B; pfam02216 703339007225 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 703339007226 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 703339007227 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 703339007228 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 703339007229 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 703339007230 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 703339007231 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 703339007232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 703339007233 catalytic residue [active] 703339007234 biotin synthase; Validated; Region: PRK06256 703339007235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339007236 FeS/SAM binding site; other site 703339007237 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 703339007238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 703339007239 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 703339007240 inhibitor-cofactor binding pocket; inhibition site 703339007241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339007242 catalytic residue [active] 703339007243 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 703339007244 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 703339007245 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 703339007246 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 703339007247 Walker A/P-loop; other site 703339007248 ATP binding site [chemical binding]; other site 703339007249 Q-loop/lid; other site 703339007250 ABC transporter signature motif; other site 703339007251 Walker B; other site 703339007252 D-loop; other site 703339007253 H-loop/switch region; other site 703339007254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 703339007255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 703339007256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339007257 Walker A/P-loop; other site 703339007258 ATP binding site [chemical binding]; other site 703339007259 Q-loop/lid; other site 703339007260 ABC transporter signature motif; other site 703339007261 Walker B; other site 703339007262 D-loop; other site 703339007263 H-loop/switch region; other site 703339007264 Predicted membrane protein [Function unknown]; Region: COG2246 703339007265 GtrA-like protein; Region: GtrA; pfam04138 703339007266 glycerate kinase; Region: TIGR00045 703339007267 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 703339007268 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 703339007269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007270 putative substrate translocation pore; other site 703339007271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 703339007272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 703339007273 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 703339007274 putative phosphoesterase; Region: acc_ester; TIGR03729 703339007275 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 703339007276 Spore germination protein; Region: Spore_permease; cl17796 703339007277 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 703339007278 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 703339007279 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 703339007280 Beta-lactamase; Region: Beta-lactamase; pfam00144 703339007281 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 703339007282 extended (e) SDRs; Region: SDR_e; cd08946 703339007283 NAD(P) binding site [chemical binding]; other site 703339007284 active site 703339007285 substrate binding site [chemical binding]; other site 703339007286 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 703339007287 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 703339007288 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 703339007289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007290 putative substrate translocation pore; other site 703339007291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339007293 dimer interface [polypeptide binding]; other site 703339007294 conserved gate region; other site 703339007295 ABC-ATPase subunit interface; other site 703339007296 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 703339007297 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 703339007298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339007299 dimer interface [polypeptide binding]; other site 703339007300 conserved gate region; other site 703339007301 putative PBP binding loops; other site 703339007302 ABC-ATPase subunit interface; other site 703339007303 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 703339007304 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 703339007305 Walker A/P-loop; other site 703339007306 ATP binding site [chemical binding]; other site 703339007307 Q-loop/lid; other site 703339007308 ABC transporter signature motif; other site 703339007309 Walker B; other site 703339007310 D-loop; other site 703339007311 H-loop/switch region; other site 703339007312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 703339007313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 703339007314 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 703339007315 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 703339007316 amino acid transporter; Region: 2A0306; TIGR00909 703339007317 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 703339007318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 703339007319 substrate binding pocket [chemical binding]; other site 703339007320 catalytic triad [active] 703339007321 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 703339007322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007323 putative substrate translocation pore; other site 703339007324 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 703339007325 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 703339007326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339007327 Walker A/P-loop; other site 703339007328 ATP binding site [chemical binding]; other site 703339007329 Q-loop/lid; other site 703339007330 ABC transporter signature motif; other site 703339007331 Walker B; other site 703339007332 D-loop; other site 703339007333 H-loop/switch region; other site 703339007334 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 703339007335 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 703339007336 oligomer interface [polypeptide binding]; other site 703339007337 active site 703339007338 metal binding site [ion binding]; metal-binding site 703339007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 703339007340 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 703339007341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 703339007342 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 703339007343 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 703339007344 active site 703339007345 FMN binding site [chemical binding]; other site 703339007346 substrate binding site [chemical binding]; other site 703339007347 3Fe-4S cluster binding site [ion binding]; other site 703339007348 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 703339007351 putative substrate translocation pore; other site 703339007352 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 703339007353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339007354 Walker A/P-loop; other site 703339007355 ATP binding site [chemical binding]; other site 703339007356 Q-loop/lid; other site 703339007357 ABC transporter signature motif; other site 703339007358 Walker B; other site 703339007359 D-loop; other site 703339007360 H-loop/switch region; other site 703339007361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 703339007362 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 703339007363 Walker A/P-loop; other site 703339007364 ATP binding site [chemical binding]; other site 703339007365 Q-loop/lid; other site 703339007366 ABC transporter signature motif; other site 703339007367 Walker B; other site 703339007368 D-loop; other site 703339007369 H-loop/switch region; other site 703339007370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 703339007371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 703339007372 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 703339007373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339007374 dimer interface [polypeptide binding]; other site 703339007375 conserved gate region; other site 703339007376 ABC-ATPase subunit interface; other site 703339007377 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 703339007378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 703339007379 dimer interface [polypeptide binding]; other site 703339007380 conserved gate region; other site 703339007381 putative PBP binding loops; other site 703339007382 ABC-ATPase subunit interface; other site 703339007383 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 703339007384 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 703339007385 substrate binding site [chemical binding]; other site 703339007386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 703339007387 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 703339007388 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 703339007389 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 703339007390 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 703339007391 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 703339007392 short chain dehydrogenase; Validated; Region: PRK08589 703339007393 classical (c) SDRs; Region: SDR_c; cd05233 703339007394 NAD(P) binding site [chemical binding]; other site 703339007395 active site 703339007396 AbgT putative transporter family; Region: ABG_transport; pfam03806 703339007397 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 703339007398 Uncharacterized conserved protein [Function unknown]; Region: COG2128 703339007399 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 703339007400 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 703339007401 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 703339007402 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 703339007403 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 703339007404 classical (c) SDRs; Region: SDR_c; cd05233 703339007405 NAD(P) binding site [chemical binding]; other site 703339007406 active site 703339007407 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 703339007408 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339007409 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339007410 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339007411 Protein of unknown function, DUF576; Region: DUF576; pfam04507 703339007412 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 703339007413 PLD-like domain; Region: PLDc_2; pfam13091 703339007414 putative homodimer interface [polypeptide binding]; other site 703339007415 putative active site [active] 703339007416 catalytic site [active] 703339007417 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 703339007418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 703339007419 ATP binding site [chemical binding]; other site 703339007420 putative Mg++ binding site [ion binding]; other site 703339007421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 703339007422 nucleotide binding region [chemical binding]; other site 703339007423 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 703339007424 ATP-binding site [chemical binding]; other site 703339007425 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 703339007426 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 703339007427 active site 703339007428 8-oxo-dGMP binding site [chemical binding]; other site 703339007429 nudix motif; other site 703339007430 metal binding site [ion binding]; metal-binding site 703339007431 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 703339007432 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 703339007433 active site 703339007434 substrate binding site [chemical binding]; other site 703339007435 metal binding site [ion binding]; metal-binding site 703339007436 H+ Antiporter protein; Region: 2A0121; TIGR00900 703339007437 G5 domain; Region: G5; pfam07501 703339007438 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 703339007439 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339007440 legume lectins; Region: lectin_L-type; cl14058 703339007441 homotetramer interaction site [polypeptide binding]; other site 703339007442 carbohydrate binding site [chemical binding]; other site 703339007443 metal binding site [ion binding]; metal-binding site 703339007444 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339007445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339007446 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339007447 Transcriptional regulators [Transcription]; Region: MarR; COG1846 703339007448 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 703339007449 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 703339007450 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 703339007451 active site 703339007452 tetramer interface; other site 703339007453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 703339007454 Transposase; Region: DDE_Tnp_ISL3; pfam01610 703339007455 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339007456 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339007457 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 703339007458 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339007459 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339007460 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 703339007461 GntP family permease; Region: GntP_permease; pfam02447 703339007462 fructuronate transporter; Provisional; Region: PRK10034; cl15264 703339007463 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 703339007464 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 703339007465 N- and C-terminal domain interface [polypeptide binding]; other site 703339007466 active site 703339007467 catalytic site [active] 703339007468 metal binding site [ion binding]; metal-binding site 703339007469 carbohydrate binding site [chemical binding]; other site 703339007470 ATP binding site [chemical binding]; other site 703339007471 Transcriptional regulators [Transcription]; Region: GntR; COG1802 703339007472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 703339007473 DNA-binding site [nucleotide binding]; DNA binding site 703339007474 FCD domain; Region: FCD; pfam07729 703339007475 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 703339007476 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 703339007477 DNA binding residues [nucleotide binding] 703339007478 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 703339007479 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 703339007480 synthetase active site [active] 703339007481 NTP binding site [chemical binding]; other site 703339007482 metal binding site [ion binding]; metal-binding site 703339007483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 703339007484 Predicted membrane protein [Function unknown]; Region: COG1289 703339007485 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 703339007486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 703339007487 D-galactonate transporter; Region: 2A0114; TIGR00893 703339007488 putative substrate translocation pore; other site 703339007489 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 703339007490 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 703339007491 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 703339007492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339007493 Walker A/P-loop; other site 703339007494 ATP binding site [chemical binding]; other site 703339007495 Q-loop/lid; other site 703339007496 ABC transporter signature motif; other site 703339007497 Walker B; other site 703339007498 D-loop; other site 703339007499 H-loop/switch region; other site 703339007500 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 703339007501 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 703339007502 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 703339007503 Uncharacterized membrane protein [Function unknown]; Region: COG3949 703339007504 Predicted esterase [General function prediction only]; Region: COG0400 703339007505 putative hydrolase; Provisional; Region: PRK11460 703339007506 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 703339007507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 703339007508 Zn binding site [ion binding]; other site 703339007509 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 703339007510 Zn binding site [ion binding]; other site 703339007511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339007512 MarR family; Region: MarR; pfam01047 703339007513 Predicted acetyltransferase [General function prediction only]; Region: COG2388 703339007514 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 703339007515 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 703339007516 putative metal binding site [ion binding]; other site 703339007517 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 703339007518 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 703339007519 dimer interface [polypeptide binding]; other site 703339007520 FMN binding site [chemical binding]; other site 703339007521 D-lactate dehydrogenase; Provisional; Region: PRK12480 703339007522 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 703339007523 homodimer interface [polypeptide binding]; other site 703339007524 ligand binding site [chemical binding]; other site 703339007525 NAD binding site [chemical binding]; other site 703339007526 catalytic site [active] 703339007527 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 703339007528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 703339007529 active site 703339007530 motif I; other site 703339007531 motif II; other site 703339007532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 703339007533 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 703339007534 Walker A/P-loop; other site 703339007535 ATP binding site [chemical binding]; other site 703339007536 Q-loop/lid; other site 703339007537 ABC transporter signature motif; other site 703339007538 Walker B; other site 703339007539 D-loop; other site 703339007540 H-loop/switch region; other site 703339007541 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 703339007542 active site 703339007543 catalytic site [active] 703339007544 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 703339007545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339007546 Coenzyme A binding pocket [chemical binding]; other site 703339007547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 703339007548 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 703339007549 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 703339007550 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 703339007551 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 703339007552 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 703339007553 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 703339007554 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 703339007555 EamA-like transporter family; Region: EamA; pfam00892 703339007556 EamA-like transporter family; Region: EamA; pfam00892 703339007557 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 703339007558 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 703339007559 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 703339007560 catalytic residues [active] 703339007561 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 703339007562 active site 703339007563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 703339007564 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 703339007565 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 703339007566 active site turn [active] 703339007567 phosphorylation site [posttranslational modification] 703339007568 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 703339007569 HPr interaction site; other site 703339007570 glycerol kinase (GK) interaction site [polypeptide binding]; other site 703339007571 active site 703339007572 phosphorylation site [posttranslational modification] 703339007573 pyruvate oxidase; Provisional; Region: PRK08611 703339007574 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 703339007575 PYR/PP interface [polypeptide binding]; other site 703339007576 tetramer interface [polypeptide binding]; other site 703339007577 dimer interface [polypeptide binding]; other site 703339007578 TPP binding site [chemical binding]; other site 703339007579 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 703339007580 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 703339007581 TPP-binding site [chemical binding]; other site 703339007582 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 703339007583 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 703339007584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 703339007585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 703339007586 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 703339007587 putative dimerization interface [polypeptide binding]; other site 703339007588 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 703339007589 Surface antigen [General function prediction only]; Region: COG3942 703339007590 CHAP domain; Region: CHAP; pfam05257 703339007591 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 703339007592 homodimer interface [polypeptide binding]; other site 703339007593 catalytic residues [active] 703339007594 NAD binding site [chemical binding]; other site 703339007595 substrate binding pocket [chemical binding]; other site 703339007596 flexible flap; other site 703339007597 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 703339007598 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 703339007599 dimer interface [polypeptide binding]; other site 703339007600 active site 703339007601 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 703339007602 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 703339007603 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 703339007604 DNA binding site [nucleotide binding] 703339007605 active site 703339007606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339007607 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 703339007608 Walker A motif; other site 703339007609 ATP binding site [chemical binding]; other site 703339007610 Walker B motif; other site 703339007611 arginine finger; other site 703339007612 UvrB/uvrC motif; Region: UVR; pfam02151 703339007613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 703339007614 Walker A motif; other site 703339007615 ATP binding site [chemical binding]; other site 703339007616 Walker B motif; other site 703339007617 arginine finger; other site 703339007618 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 703339007619 Virus attachment protein p12 family; Region: P12; pfam12669 703339007620 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 703339007621 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 703339007622 G1 box; other site 703339007623 GTP/Mg2+ binding site [chemical binding]; other site 703339007624 Switch I region; other site 703339007625 G2 box; other site 703339007626 G3 box; other site 703339007627 Switch II region; other site 703339007628 G4 box; other site 703339007629 G5 box; other site 703339007630 Nucleoside recognition; Region: Gate; pfam07670 703339007631 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 703339007632 Nucleoside recognition; Region: Gate; pfam07670 703339007633 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 703339007634 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 703339007635 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 703339007636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 703339007637 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 703339007638 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 703339007639 Glutamate binding site [chemical binding]; other site 703339007640 homodimer interface [polypeptide binding]; other site 703339007641 NAD binding site [chemical binding]; other site 703339007642 catalytic residues [active] 703339007643 maltose O-acetyltransferase; Provisional; Region: PRK10092 703339007644 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 703339007645 active site 703339007646 substrate binding site [chemical binding]; other site 703339007647 trimer interface [polypeptide binding]; other site 703339007648 CoA binding site [chemical binding]; other site 703339007649 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 703339007650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 703339007651 metal-binding site [ion binding] 703339007652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 703339007653 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 703339007654 metal-binding site [ion binding] 703339007655 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 703339007656 Soluble P-type ATPase [General function prediction only]; Region: COG4087 703339007657 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 703339007658 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 703339007659 metal-binding site [ion binding] 703339007660 D-lactate dehydrogenase; Validated; Region: PRK08605 703339007661 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 703339007662 homodimer interface [polypeptide binding]; other site 703339007663 ligand binding site [chemical binding]; other site 703339007664 NAD binding site [chemical binding]; other site 703339007665 catalytic site [active] 703339007666 transaminase; Reviewed; Region: PRK08068 703339007667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339007668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339007669 homodimer interface [polypeptide binding]; other site 703339007670 catalytic residue [active] 703339007671 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 703339007672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 703339007673 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 703339007674 active site lid residues [active] 703339007675 substrate binding pocket [chemical binding]; other site 703339007676 catalytic residues [active] 703339007677 substrate-Mg2+ binding site; other site 703339007678 aspartate-rich region 1; other site 703339007679 aspartate-rich region 2; other site 703339007680 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 703339007681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 703339007682 active site 703339007683 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 703339007684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 703339007685 Surface antigen [General function prediction only]; Region: COG3942 703339007686 CHAP domain; Region: CHAP; pfam05257 703339007687 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 703339007688 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 703339007689 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 703339007690 catalytic triad [active] 703339007691 catalytic triad [active] 703339007692 oxyanion hole [active] 703339007693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339007694 Coenzyme A binding pocket [chemical binding]; other site 703339007695 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 703339007696 N-acetyl-D-glucosamine binding site [chemical binding]; other site 703339007697 catalytic residue [active] 703339007698 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 703339007699 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 703339007700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 703339007701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 703339007702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 703339007703 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339007704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 703339007705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 703339007706 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 703339007707 NmrA-like family; Region: NmrA; pfam05368 703339007708 NADP binding site [chemical binding]; other site 703339007709 active site 703339007710 regulatory binding site [polypeptide binding]; other site 703339007711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 703339007712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 703339007713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 703339007714 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 703339007715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 703339007716 NAD(P) binding site [chemical binding]; other site 703339007717 active site 703339007718 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 703339007719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 703339007720 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 703339007721 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 703339007722 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 703339007723 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 703339007724 Nucleoside recognition; Region: Gate; pfam07670 703339007725 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 703339007726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 703339007727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 703339007728 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 703339007729 Phosphotransferase enzyme family; Region: APH; pfam01636 703339007730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 703339007731 active site 703339007732 ATP binding site [chemical binding]; other site 703339007733 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 703339007734 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 703339007735 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 703339007736 quinone interaction residues [chemical binding]; other site 703339007737 active site 703339007738 catalytic residues [active] 703339007739 FMN binding site [chemical binding]; other site 703339007740 substrate binding site [chemical binding]; other site 703339007741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 703339007742 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 703339007743 dimer interface [polypeptide binding]; other site 703339007744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 703339007745 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 703339007746 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 703339007747 Predicted acyl esterases [General function prediction only]; Region: COG2936 703339007748 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 703339007749 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339007750 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 703339007751 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 703339007752 tetramerization interface [polypeptide binding]; other site 703339007753 active site 703339007754 pantoate--beta-alanine ligase; Region: panC; TIGR00018 703339007755 Pantoate-beta-alanine ligase; Region: PanC; cd00560 703339007756 active site 703339007757 ATP-binding site [chemical binding]; other site 703339007758 pantoate-binding site; other site 703339007759 HXXH motif; other site 703339007760 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 703339007761 oligomerization interface [polypeptide binding]; other site 703339007762 active site 703339007763 metal binding site [ion binding]; metal-binding site 703339007764 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 703339007765 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 703339007766 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 703339007767 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 703339007768 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 703339007769 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 703339007770 tetramer (dimer of dimers) interface [polypeptide binding]; other site 703339007771 NAD binding site [chemical binding]; other site 703339007772 dimer interface [polypeptide binding]; other site 703339007773 substrate binding site [chemical binding]; other site 703339007774 amino acid transporter; Region: 2A0306; TIGR00909 703339007775 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 703339007776 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 703339007777 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 703339007778 inhibitor-cofactor binding pocket; inhibition site 703339007779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339007780 catalytic residue [active] 703339007781 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 703339007782 catalytic residue [active] 703339007783 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 703339007784 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 703339007785 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 703339007786 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 703339007787 acyl-activating enzyme (AAE) consensus motif; other site 703339007788 AMP binding site [chemical binding]; other site 703339007789 active site 703339007790 CoA binding site [chemical binding]; other site 703339007791 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 703339007792 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 703339007793 choline dehydrogenase; Validated; Region: PRK02106 703339007794 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 703339007795 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 703339007796 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 703339007797 tetramerization interface [polypeptide binding]; other site 703339007798 NAD(P) binding site [chemical binding]; other site 703339007799 catalytic residues [active] 703339007800 Predicted transcriptional regulators [Transcription]; Region: COG1510 703339007801 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 703339007802 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 703339007803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 703339007804 FeS/SAM binding site; other site 703339007805 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 703339007806 Class III ribonucleotide reductase; Region: RNR_III; cd01675 703339007807 effector binding site; other site 703339007808 active site 703339007809 Zn binding site [ion binding]; other site 703339007810 glycine loop; other site 703339007811 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 703339007812 Citrate transporter; Region: CitMHS; pfam03600 703339007813 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 703339007814 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 703339007815 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 703339007816 Flavodoxin; Region: Flavodoxin_1; pfam00258 703339007817 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 703339007818 FAD binding pocket [chemical binding]; other site 703339007819 FAD binding motif [chemical binding]; other site 703339007820 catalytic residues [active] 703339007821 NAD binding pocket [chemical binding]; other site 703339007822 phosphate binding motif [ion binding]; other site 703339007823 beta-alpha-beta structure motif; other site 703339007824 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 703339007825 catalytic residues [active] 703339007826 dimer interface [polypeptide binding]; other site 703339007827 FtsX-like permease family; Region: FtsX; pfam02687 703339007828 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 703339007829 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339007830 Walker A/P-loop; other site 703339007831 ATP binding site [chemical binding]; other site 703339007832 Q-loop/lid; other site 703339007833 ABC transporter signature motif; other site 703339007834 Walker B; other site 703339007835 D-loop; other site 703339007836 H-loop/switch region; other site 703339007837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 703339007838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 703339007839 ATP binding site [chemical binding]; other site 703339007840 Mg2+ binding site [ion binding]; other site 703339007841 G-X-G motif; other site 703339007842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 703339007843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 703339007844 active site 703339007845 phosphorylation site [posttranslational modification] 703339007846 intermolecular recognition site; other site 703339007847 dimerization interface [polypeptide binding]; other site 703339007848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 703339007849 DNA binding site [nucleotide binding] 703339007850 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 703339007851 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 703339007852 dimer interface [polypeptide binding]; other site 703339007853 active site 703339007854 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 703339007855 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 703339007856 MarR family; Region: MarR_2; pfam12802 703339007857 Predicted esterase [General function prediction only]; Region: COG0627 703339007858 S-formylglutathione hydrolase; Region: PLN02442 703339007859 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 703339007860 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 703339007861 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 703339007862 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 703339007863 ligand binding site [chemical binding]; other site 703339007864 flexible hinge region; other site 703339007865 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 703339007866 carbamate kinase; Reviewed; Region: PRK12686 703339007867 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 703339007868 putative substrate binding site [chemical binding]; other site 703339007869 nucleotide binding site [chemical binding]; other site 703339007870 nucleotide binding site [chemical binding]; other site 703339007871 homodimer interface [polypeptide binding]; other site 703339007872 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 703339007873 ornithine carbamoyltransferase; Validated; Region: PRK02102 703339007874 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 703339007875 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 703339007876 arginine deiminase; Provisional; Region: PRK01388 703339007877 Arginine repressor [Transcription]; Region: ArgR; COG1438 703339007878 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 703339007879 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 703339007880 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 703339007881 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 703339007882 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 703339007883 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 703339007884 active site 703339007885 Zn binding site [ion binding]; other site 703339007886 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 703339007887 HTH domain; Region: HTH_11; pfam08279 703339007888 PRD domain; Region: PRD; pfam00874 703339007889 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 703339007890 active site 703339007891 P-loop; other site 703339007892 phosphorylation site [posttranslational modification] 703339007893 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339007894 active site 703339007895 phosphorylation site [posttranslational modification] 703339007896 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 703339007897 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 703339007898 active site 703339007899 P-loop; other site 703339007900 phosphorylation site [posttranslational modification] 703339007901 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 703339007902 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 703339007903 active site 703339007904 phosphorylation site [posttranslational modification] 703339007905 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 703339007906 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 703339007907 Predicted membrane protein [Function unknown]; Region: COG1511 703339007908 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 703339007909 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 703339007910 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 703339007911 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 703339007912 CHAP domain; Region: CHAP; pfam05257 703339007913 Isochorismatase family; Region: Isochorismatase; pfam00857 703339007914 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 703339007915 catalytic triad [active] 703339007916 conserved cis-peptide bond; other site 703339007917 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 703339007918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 703339007919 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 703339007920 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 703339007921 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 703339007922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 703339007923 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 703339007924 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 703339007925 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 703339007926 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 703339007927 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 703339007928 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 703339007929 SecY translocase; Region: SecY; pfam00344 703339007930 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 703339007931 legume lectins; Region: lectin_L-type; cd01951 703339007932 homotetramer interaction site [polypeptide binding]; other site 703339007933 carbohydrate binding site [chemical binding]; other site 703339007934 metal binding site [ion binding]; metal-binding site 703339007935 Putative Ig domain; Region: He_PIG; pfam05345 703339007936 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 703339007937 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 703339007938 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 703339007939 methionine sulfoxide reductase A; Provisional; Region: PRK05528 703339007940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 703339007941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 703339007942 Coenzyme A binding pocket [chemical binding]; other site 703339007943 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 703339007944 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 703339007945 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 703339007946 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 703339007947 Chain length determinant protein; Region: Wzz; cl15801 703339007948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 703339007949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 703339007950 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 703339007951 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 703339007952 DXD motif; other site 703339007953 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 703339007954 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 703339007955 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 703339007956 Acyltransferase family; Region: Acyl_transf_3; pfam01757 703339007957 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339007958 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 703339007959 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 703339007960 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 703339007961 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 703339007962 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 703339007963 metal binding site [ion binding]; metal-binding site 703339007964 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 703339007965 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 703339007966 substrate binding site [chemical binding]; other site 703339007967 glutamase interaction surface [polypeptide binding]; other site 703339007968 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 703339007969 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 703339007970 catalytic residues [active] 703339007971 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 703339007972 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 703339007973 putative active site [active] 703339007974 oxyanion strand; other site 703339007975 catalytic triad [active] 703339007976 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 703339007977 putative active site pocket [active] 703339007978 4-fold oligomerization interface [polypeptide binding]; other site 703339007979 metal binding residues [ion binding]; metal-binding site 703339007980 3-fold/trimer interface [polypeptide binding]; other site 703339007981 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 703339007982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 703339007983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 703339007984 homodimer interface [polypeptide binding]; other site 703339007985 catalytic residue [active] 703339007986 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 703339007987 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 703339007988 NAD binding site [chemical binding]; other site 703339007989 dimerization interface [polypeptide binding]; other site 703339007990 product binding site; other site 703339007991 substrate binding site [chemical binding]; other site 703339007992 zinc binding site [ion binding]; other site 703339007993 catalytic residues [active] 703339007994 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 703339007995 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 703339007996 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 703339007997 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 703339007998 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 703339007999 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 703339008000 putative active site [active] 703339008001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 703339008002 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 703339008003 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 703339008004 Walker A/P-loop; other site 703339008005 ATP binding site [chemical binding]; other site 703339008006 ABC transporter; Region: ABC_tran; pfam00005 703339008007 Q-loop/lid; other site 703339008008 ABC transporter signature motif; other site 703339008009 Walker B; other site 703339008010 D-loop; other site 703339008011 H-loop/switch region; other site 703339008012 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 703339008013 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 703339008014 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 703339008015 Walker A/P-loop; other site 703339008016 ATP binding site [chemical binding]; other site 703339008017 Q-loop/lid; other site 703339008018 ABC transporter signature motif; other site 703339008019 Walker B; other site 703339008020 D-loop; other site 703339008021 H-loop/switch region; other site 703339008022 hypothetical protein; Provisional; Region: PRK13661 703339008023 Uncharacterized conserved protein [Function unknown]; Region: COG1912 703339008024 Uncharacterized conserved protein [Function unknown]; Region: COG2353 703339008025 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 703339008026 Strictosidine synthase; Region: Str_synth; pfam03088 703339008027 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 703339008028 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 703339008029 active site residue [active] 703339008030 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 703339008031 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 703339008032 putative substrate binding pocket [chemical binding]; other site 703339008033 AC domain interface; other site 703339008034 catalytic triad [active] 703339008035 AB domain interface; other site 703339008036 interchain disulfide; other site 703339008037 Predicted transcriptional regulators [Transcription]; Region: COG1695 703339008038 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 703339008039 DinB superfamily; Region: DinB_2; pfam12867 703339008040 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 703339008041 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 703339008042 transmembrane helices; other site 703339008043 Predicted permeases [General function prediction only]; Region: RarD; COG2962 703339008044 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 703339008045 hypothetical protein; Provisional; Region: PRK07758 703339008046 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 703339008047 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 703339008048 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 703339008049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 703339008050 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 703339008051 Walker A/P-loop; other site 703339008052 ATP binding site [chemical binding]; other site 703339008053 Q-loop/lid; other site 703339008054 ABC transporter signature motif; other site 703339008055 Walker B; other site 703339008056 D-loop; other site 703339008057 H-loop/switch region; other site 703339008058 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 703339008059 FtsX-like permease family; Region: FtsX; pfam02687 703339008060 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 703339008061 DNA-binding site [nucleotide binding]; DNA binding site 703339008062 RNA-binding motif; other site 703339008063 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 703339008064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 703339008065 non-specific DNA binding site [nucleotide binding]; other site 703339008066 salt bridge; other site 703339008067 sequence-specific DNA binding site [nucleotide binding]; other site 703339008068 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 703339008069 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 703339008070 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 703339008071 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 703339008072 ParB-like nuclease domain; Region: ParBc; pfam02195 703339008073 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 703339008074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 703339008075 S-adenosylmethionine binding site [chemical binding]; other site 703339008076 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 703339008077 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 703339008078 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 703339008079 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 703339008080 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 703339008081 trmE is a tRNA modification GTPase; Region: trmE; cd04164 703339008082 G1 box; other site 703339008083 GTP/Mg2+ binding site [chemical binding]; other site 703339008084 Switch I region; other site 703339008085 G2 box; other site 703339008086 Switch II region; other site 703339008087 G3 box; other site 703339008088 G4 box; other site 703339008089 G5 box; other site 703339008090 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 703339008091 ribonuclease P; Reviewed; Region: rnpA; PRK00499 703339008092 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399