-- dump date   	20140620_073122
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1229492000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1229492000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1229492000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492000004	Walker A motif; other site
1229492000005	ATP binding site [chemical binding]; other site
1229492000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229492000007	Walker B motif; other site
1229492000008	arginine finger; other site
1229492000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1229492000010	DnaA box-binding interface [nucleotide binding]; other site
1229492000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1229492000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1229492000013	putative DNA binding surface [nucleotide binding]; other site
1229492000014	dimer interface [polypeptide binding]; other site
1229492000015	beta-clamp/clamp loader binding surface; other site
1229492000016	beta-clamp/translesion DNA polymerase binding surface; other site
1229492000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1229492000018	recF protein; Region: recf; TIGR00611
1229492000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1229492000020	Walker A/P-loop; other site
1229492000021	ATP binding site [chemical binding]; other site
1229492000022	Q-loop/lid; other site
1229492000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492000024	ABC transporter signature motif; other site
1229492000025	Walker B; other site
1229492000026	D-loop; other site
1229492000027	H-loop/switch region; other site
1229492000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1229492000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492000030	Mg2+ binding site [ion binding]; other site
1229492000031	G-X-G motif; other site
1229492000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1229492000033	anchoring element; other site
1229492000034	dimer interface [polypeptide binding]; other site
1229492000035	ATP binding site [chemical binding]; other site
1229492000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1229492000037	active site
1229492000038	putative metal-binding site [ion binding]; other site
1229492000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1229492000040	DNA gyrase subunit A; Validated; Region: PRK05560
1229492000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1229492000042	CAP-like domain; other site
1229492000043	active site
1229492000044	primary dimer interface [polypeptide binding]; other site
1229492000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492000051	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1229492000052	putative substrate binding site [chemical binding]; other site
1229492000053	putative ATP binding site [chemical binding]; other site
1229492000054	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1229492000055	active sites [active]
1229492000056	tetramer interface [polypeptide binding]; other site
1229492000057	seryl-tRNA synthetase; Provisional; Region: PRK05431
1229492000058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1229492000059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1229492000060	dimer interface [polypeptide binding]; other site
1229492000061	active site
1229492000062	motif 1; other site
1229492000063	motif 2; other site
1229492000064	motif 3; other site
1229492000065	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1229492000066	Predicted membrane protein [Function unknown]; Region: COG4392
1229492000067	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1229492000068	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1229492000069	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
1229492000070	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1229492000071	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1229492000072	DHH family; Region: DHH; pfam01368
1229492000073	DHHA1 domain; Region: DHHA1; pfam02272
1229492000074	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1229492000075	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1229492000076	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1229492000077	replicative DNA helicase; Region: DnaB; TIGR00665
1229492000078	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1229492000079	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1229492000080	Walker A motif; other site
1229492000081	ATP binding site [chemical binding]; other site
1229492000082	Walker B motif; other site
1229492000083	DNA binding loops [nucleotide binding]
1229492000084	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1229492000085	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1229492000086	GDP-binding site [chemical binding]; other site
1229492000087	ACT binding site; other site
1229492000088	IMP binding site; other site
1229492000089	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1229492000090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492000091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492000092	active site
1229492000093	phosphorylation site [posttranslational modification]
1229492000094	intermolecular recognition site; other site
1229492000095	dimerization interface [polypeptide binding]; other site
1229492000096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492000097	DNA binding site [nucleotide binding]
1229492000098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1229492000099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229492000100	dimerization interface [polypeptide binding]; other site
1229492000101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229492000102	putative active site [active]
1229492000103	heme pocket [chemical binding]; other site
1229492000104	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492000105	dimer interface [polypeptide binding]; other site
1229492000106	phosphorylation site [posttranslational modification]
1229492000107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492000108	ATP binding site [chemical binding]; other site
1229492000109	Mg2+ binding site [ion binding]; other site
1229492000110	G-X-G motif; other site
1229492000111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1229492000112	YycH protein; Region: YycH; pfam07435
1229492000113	YycH protein; Region: YycI; cl02015
1229492000114	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1229492000115	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1229492000116	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1229492000117	putative active site [active]
1229492000118	putative metal binding site [ion binding]; other site
1229492000119	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229492000120	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1229492000121	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1229492000122	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
1229492000123	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1229492000124	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1229492000125	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229492000126	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1229492000127	substrate binding site [chemical binding]; other site
1229492000128	ATP binding site [chemical binding]; other site
1229492000129	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1229492000130	Integrase core domain; Region: rve; pfam00665
1229492000131	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
1229492000132	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1229492000133	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229492000134	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1229492000135	putative active site [active]
1229492000136	catalytic site [active]
1229492000137	putative metal binding site [ion binding]; other site
1229492000138	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1229492000139	putative active site [active]
1229492000140	putative catalytic site [active]
1229492000141	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1229492000142	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229492000143	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229492000144	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229492000145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1229492000146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1229492000147	Integrase core domain; Region: rve; pfam00665
1229492000148	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1229492000149	dimer interface [polypeptide binding]; other site
1229492000150	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229492000151	Predicted transcriptional regulator [Transcription]; Region: COG2378
1229492000152	HTH domain; Region: HTH_11; pfam08279
1229492000153	WYL domain; Region: WYL; pfam13280
1229492000154	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
1229492000155	active site
1229492000156	DNA binding site [nucleotide binding]
1229492000157	catalytic site [active]
1229492000158	Phage associated DNA primase [General function prediction only]; Region: COG3378
1229492000159	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1229492000160	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1229492000161	catalytic residues [active]
1229492000162	catalytic nucleophile [active]
1229492000163	Recombinase; Region: Recombinase; pfam07508
1229492000164	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1229492000165	FlxA-like protein; Region: FlxA; pfam14282
1229492000166	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
1229492000167	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1229492000168	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1229492000169	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1229492000170	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
1229492000171	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
1229492000172	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
1229492000173	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
1229492000174	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
1229492000175	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684
1229492000176	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
1229492000177	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
1229492000178	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
1229492000179	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
1229492000180	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492000181	AAA domain; Region: AAA_13; pfam13166
1229492000182	Walker A/P-loop; other site
1229492000183	ATP binding site [chemical binding]; other site
1229492000184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229492000185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492000186	Walker A motif; other site
1229492000187	ATP binding site [chemical binding]; other site
1229492000188	Walker B motif; other site
1229492000189	proteasome-activating nucleotidase; Provisional; Region: PRK03992
1229492000190	Integrase core domain; Region: rve; pfam00665
1229492000191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1229492000192	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1229492000193	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1229492000194	active site
1229492000195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492000197	putative substrate translocation pore; other site
1229492000198	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1229492000199	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1229492000200	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492000201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492000202	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492000203	Coenzyme A binding pocket [chemical binding]; other site
1229492000204	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1229492000205	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1229492000206	FMN binding site [chemical binding]; other site
1229492000207	active site
1229492000208	catalytic residues [active]
1229492000209	substrate binding site [chemical binding]; other site
1229492000210	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
1229492000211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000212	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229492000213	putative substrate translocation pore; other site
1229492000214	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1229492000215	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1229492000216	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229492000217	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229492000218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229492000219	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229492000220	dimerization interface [polypeptide binding]; other site
1229492000221	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1229492000222	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1229492000223	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492000224	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229492000225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492000226	S-adenosylmethionine binding site [chemical binding]; other site
1229492000227	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1229492000228	active site
1229492000229	catalytic site [active]
1229492000230	putative metal binding site [ion binding]; other site
1229492000231	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492000232	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229492000233	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229492000234	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1229492000235	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229492000236	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1229492000237	metal binding site [ion binding]; metal-binding site
1229492000238	dimer interface [polypeptide binding]; other site
1229492000239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000240	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492000241	putative substrate translocation pore; other site
1229492000242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000243	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1229492000244	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1229492000245	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1229492000246	PhoU domain; Region: PhoU; pfam01895
1229492000247	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
1229492000248	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1229492000249	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1229492000250	L-lactate permease; Region: Lactate_perm; cl00701
1229492000251	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492000252	B domain; Region: B; pfam02216
1229492000253	B domain; Region: B; pfam02216
1229492000254	B domain; Region: B; pfam02216
1229492000255	B domain; Region: B; pfam02216
1229492000256	B domain; Region: B; pfam02216
1229492000257	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492000258	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492000259	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229492000260	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492000261	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229492000262	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229492000263	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492000264	ABC-ATPase subunit  interface; other site
1229492000265	dimer interface [polypeptide binding]; other site
1229492000266	putative PBP binding regions; other site
1229492000267	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229492000268	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492000269	ABC-ATPase subunit  interface; other site
1229492000270	dimer interface [polypeptide binding]; other site
1229492000271	putative PBP binding regions; other site
1229492000272	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1229492000273	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1229492000274	siderophore binding site; other site
1229492000275	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1229492000276	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1229492000277	dimer interface [polypeptide binding]; other site
1229492000278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492000279	catalytic residue [active]
1229492000280	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1229492000281	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229492000282	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1229492000283	IucA / IucC family; Region: IucA_IucC; pfam04183
1229492000284	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1229492000285	drug efflux system protein MdtG; Provisional; Region: PRK09874
1229492000286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000287	putative substrate translocation pore; other site
1229492000288	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1229492000289	IucA / IucC family; Region: IucA_IucC; pfam04183
1229492000290	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1229492000291	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1229492000292	IucA / IucC family; Region: IucA_IucC; pfam04183
1229492000293	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1229492000294	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1229492000295	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1229492000296	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
1229492000297	dimer interface [polypeptide binding]; other site
1229492000298	active site
1229492000299	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229492000300	catalytic residues [active]
1229492000301	substrate binding site [chemical binding]; other site
1229492000302	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1229492000303	ParB-like nuclease domain; Region: ParBc; pfam02195
1229492000304	acetoin reductase; Validated; Region: PRK08643
1229492000305	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1229492000306	NAD binding site [chemical binding]; other site
1229492000307	homotetramer interface [polypeptide binding]; other site
1229492000308	homodimer interface [polypeptide binding]; other site
1229492000309	active site
1229492000310	substrate binding site [chemical binding]; other site
1229492000311	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229492000312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492000313	NAD(P) binding site [chemical binding]; other site
1229492000314	active site
1229492000315	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1229492000316	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1229492000317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229492000318	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1229492000319	putative ADP-binding pocket [chemical binding]; other site
1229492000320	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229492000321	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1229492000322	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1229492000323	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1229492000324	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1229492000325	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229492000326	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229492000327	DNA-binding site [nucleotide binding]; DNA binding site
1229492000328	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1229492000329	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1229492000330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492000331	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1229492000332	intersubunit interface [polypeptide binding]; other site
1229492000333	active site
1229492000334	catalytic residue [active]
1229492000335	phosphopentomutase; Provisional; Region: PRK05362
1229492000336	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1229492000337	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1229492000338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492000339	dimer interface [polypeptide binding]; other site
1229492000340	conserved gate region; other site
1229492000341	putative PBP binding loops; other site
1229492000342	ABC-ATPase subunit interface; other site
1229492000343	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1229492000344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492000345	dimer interface [polypeptide binding]; other site
1229492000346	conserved gate region; other site
1229492000347	ABC-ATPase subunit interface; other site
1229492000348	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1229492000349	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1229492000350	Walker A/P-loop; other site
1229492000351	ATP binding site [chemical binding]; other site
1229492000352	Q-loop/lid; other site
1229492000353	ABC transporter signature motif; other site
1229492000354	Walker B; other site
1229492000355	D-loop; other site
1229492000356	H-loop/switch region; other site
1229492000357	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1229492000358	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229492000359	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1229492000360	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1229492000361	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1229492000362	active site
1229492000363	metal binding site [ion binding]; metal-binding site
1229492000364	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229492000365	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229492000366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492000367	non-specific DNA binding site [nucleotide binding]; other site
1229492000368	salt bridge; other site
1229492000369	sequence-specific DNA binding site [nucleotide binding]; other site
1229492000370	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1229492000371	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1229492000372	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1229492000373	putative catalytic cysteine [active]
1229492000374	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1229492000375	putative active site [active]
1229492000376	metal binding site [ion binding]; metal-binding site
1229492000377	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1229492000378	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1229492000379	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1229492000380	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229492000381	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1229492000382	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1229492000383	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1229492000384	NAD(P) binding site [chemical binding]; other site
1229492000385	homodimer interface [polypeptide binding]; other site
1229492000386	substrate binding site [chemical binding]; other site
1229492000387	active site
1229492000388	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
1229492000389	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1229492000390	NAD(P) binding site [chemical binding]; other site
1229492000391	homodimer interface [polypeptide binding]; other site
1229492000392	substrate binding site [chemical binding]; other site
1229492000393	active site
1229492000394	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
1229492000395	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
1229492000396	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1229492000397	putative NAD(P) binding site [chemical binding]; other site
1229492000398	active site
1229492000399	putative substrate binding site [chemical binding]; other site
1229492000400	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1229492000401	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1229492000402	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1229492000403	active site
1229492000404	homodimer interface [polypeptide binding]; other site
1229492000405	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1229492000406	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1229492000407	trimer interface [polypeptide binding]; other site
1229492000408	active site
1229492000409	substrate binding site [chemical binding]; other site
1229492000410	CoA binding site [chemical binding]; other site
1229492000411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229492000412	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229492000413	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1229492000414	O-Antigen ligase; Region: Wzy_C; pfam04932
1229492000415	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229492000416	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1229492000417	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229492000418	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1229492000419	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1229492000420	putative NAD(P) binding site [chemical binding]; other site
1229492000421	active site
1229492000422	putative substrate binding site [chemical binding]; other site
1229492000423	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1229492000424	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229492000425	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1229492000426	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1229492000427	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1229492000428	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1229492000429	active site
1229492000430	homodimer interface [polypeptide binding]; other site
1229492000431	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
1229492000432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1229492000433	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1229492000434	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229492000435	NAD(P) binding site [chemical binding]; other site
1229492000436	catalytic residues [active]
1229492000437	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1229492000438	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1229492000439	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
1229492000440	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229492000441	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229492000442	Walker A/P-loop; other site
1229492000443	ATP binding site [chemical binding]; other site
1229492000444	Q-loop/lid; other site
1229492000445	ABC transporter signature motif; other site
1229492000446	Walker B; other site
1229492000447	D-loop; other site
1229492000448	H-loop/switch region; other site
1229492000449	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1229492000450	NMT1-like family; Region: NMT1_2; pfam13379
1229492000451	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229492000452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229492000453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229492000454	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229492000455	active site
1229492000456	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1229492000457	formate dehydrogenase; Provisional; Region: PRK07574
1229492000458	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1229492000459	dimerization interface [polypeptide binding]; other site
1229492000460	ligand binding site [chemical binding]; other site
1229492000461	NAD binding site [chemical binding]; other site
1229492000462	catalytic site [active]
1229492000463	putative transporter; Provisional; Region: PRK10054
1229492000464	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1229492000465	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1229492000466	acyl-activating enzyme (AAE) consensus motif; other site
1229492000467	AMP binding site [chemical binding]; other site
1229492000468	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1229492000469	Condensation domain; Region: Condensation; pfam00668
1229492000470	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1229492000471	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1229492000472	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1229492000473	acyl-activating enzyme (AAE) consensus motif; other site
1229492000474	AMP binding site [chemical binding]; other site
1229492000475	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1229492000476	thioester reductase domain; Region: Thioester-redct; TIGR01746
1229492000477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492000478	NAD(P) binding site [chemical binding]; other site
1229492000479	active site
1229492000480	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1229492000481	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1229492000482	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
1229492000483	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1229492000484	nucleotide binding site [chemical binding]; other site
1229492000485	N-acetyl-L-glutamate binding site [chemical binding]; other site
1229492000486	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1229492000487	heterotetramer interface [polypeptide binding]; other site
1229492000488	active site pocket [active]
1229492000489	cleavage site
1229492000490	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1229492000491	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229492000492	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1229492000493	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229492000494	inhibitor-cofactor binding pocket; inhibition site
1229492000495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492000496	catalytic residue [active]
1229492000497	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229492000498	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492000499	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492000500	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1229492000501	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1229492000502	Isochorismatase family; Region: Isochorismatase; pfam00857
1229492000503	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229492000504	catalytic triad [active]
1229492000505	conserved cis-peptide bond; other site
1229492000506	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1229492000507	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1229492000508	dimer interface [polypeptide binding]; other site
1229492000509	PYR/PP interface [polypeptide binding]; other site
1229492000510	TPP binding site [chemical binding]; other site
1229492000511	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229492000512	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1229492000513	TPP-binding site [chemical binding]; other site
1229492000514	dimer interface [polypeptide binding]; other site
1229492000515	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492000516	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1229492000517	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492000518	active site turn [active]
1229492000519	phosphorylation site [posttranslational modification]
1229492000520	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1229492000521	HPr interaction site; other site
1229492000522	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229492000523	active site
1229492000524	phosphorylation site [posttranslational modification]
1229492000525	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1229492000526	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1229492000527	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
1229492000528	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1229492000529	putative active site [active]
1229492000530	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1229492000531	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492000532	active site turn [active]
1229492000533	phosphorylation site [posttranslational modification]
1229492000534	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492000535	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229492000536	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229492000537	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229492000538	putative active site [active]
1229492000539	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1229492000540	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1229492000541	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492000542	ATP binding site [chemical binding]; other site
1229492000543	putative Mg++ binding site [ion binding]; other site
1229492000544	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1229492000545	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492000546	Walker A/P-loop; other site
1229492000547	ATP binding site [chemical binding]; other site
1229492000548	Q-loop/lid; other site
1229492000549	ABC transporter signature motif; other site
1229492000550	Walker B; other site
1229492000551	D-loop; other site
1229492000552	H-loop/switch region; other site
1229492000553	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1229492000554	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492000555	Walker A/P-loop; other site
1229492000556	ATP binding site [chemical binding]; other site
1229492000557	Q-loop/lid; other site
1229492000558	ABC transporter signature motif; other site
1229492000559	Walker B; other site
1229492000560	D-loop; other site
1229492000561	H-loop/switch region; other site
1229492000562	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229492000563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492000564	dimer interface [polypeptide binding]; other site
1229492000565	conserved gate region; other site
1229492000566	putative PBP binding loops; other site
1229492000567	ABC-ATPase subunit interface; other site
1229492000568	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1229492000569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492000570	dimer interface [polypeptide binding]; other site
1229492000571	conserved gate region; other site
1229492000572	ABC-ATPase subunit interface; other site
1229492000573	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1229492000574	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1229492000575	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1229492000576	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1229492000577	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1229492000578	Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742
1229492000579	azoreductase; Reviewed; Region: PRK00170
1229492000580	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229492000581	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1229492000582	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229492000583	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1229492000584	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1229492000585	Walker A/P-loop; other site
1229492000586	ATP binding site [chemical binding]; other site
1229492000587	Q-loop/lid; other site
1229492000588	ABC transporter signature motif; other site
1229492000589	Walker B; other site
1229492000590	D-loop; other site
1229492000591	H-loop/switch region; other site
1229492000592	TOBE domain; Region: TOBE; pfam03459
1229492000593	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1229492000594	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229492000595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492000596	dimer interface [polypeptide binding]; other site
1229492000597	conserved gate region; other site
1229492000598	ABC-ATPase subunit interface; other site
1229492000599	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229492000600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492000601	dimer interface [polypeptide binding]; other site
1229492000602	conserved gate region; other site
1229492000603	putative PBP binding loops; other site
1229492000604	ABC-ATPase subunit interface; other site
1229492000605	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229492000606	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229492000607	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229492000608	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229492000609	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229492000610	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229492000611	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1229492000612	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1229492000613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1229492000614	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1229492000615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000616	putative substrate translocation pore; other site
1229492000617	Response regulator receiver domain; Region: Response_reg; pfam00072
1229492000618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492000619	active site
1229492000620	phosphorylation site [posttranslational modification]
1229492000621	intermolecular recognition site; other site
1229492000622	dimerization interface [polypeptide binding]; other site
1229492000623	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229492000624	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229492000625	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229492000626	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1229492000627	Histidine kinase; Region: His_kinase; pfam06580
1229492000628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492000629	ATP binding site [chemical binding]; other site
1229492000630	Mg2+ binding site [ion binding]; other site
1229492000631	G-X-G motif; other site
1229492000632	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1229492000633	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229492000634	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1229492000635	Pyruvate formate lyase 1; Region: PFL1; cd01678
1229492000636	coenzyme A binding site [chemical binding]; other site
1229492000637	active site
1229492000638	catalytic residues [active]
1229492000639	glycine loop; other site
1229492000640	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1229492000641	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492000642	FeS/SAM binding site; other site
1229492000643	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229492000644	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
1229492000645	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229492000646	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1229492000647	putative active site [active]
1229492000648	catalytic site [active]
1229492000649	putative metal binding site [ion binding]; other site
1229492000650	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1229492000651	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1229492000652	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1229492000653	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1229492000654	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1229492000655	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1229492000656	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1229492000657	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229492000658	dimer interface [polypeptide binding]; other site
1229492000659	active site
1229492000660	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1229492000661	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229492000662	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229492000663	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229492000664	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1229492000665	substrate binding site [chemical binding]; other site
1229492000666	oxyanion hole (OAH) forming residues; other site
1229492000667	trimer interface [polypeptide binding]; other site
1229492000668	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229492000669	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229492000670	active site
1229492000671	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1229492000672	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229492000673	acyl-activating enzyme (AAE) consensus motif; other site
1229492000674	AMP binding site [chemical binding]; other site
1229492000675	active site
1229492000676	CoA binding site [chemical binding]; other site
1229492000677	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1229492000678	Coenzyme A transferase; Region: CoA_trans; smart00882
1229492000679	Coenzyme A transferase; Region: CoA_trans; cl17247
1229492000680	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1229492000681	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1229492000682	catalytic triad [active]
1229492000683	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1229492000684	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1229492000685	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1229492000686	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1229492000687	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1229492000688	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1229492000689	heme-binding site [chemical binding]; other site
1229492000690	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1229492000691	FAD binding pocket [chemical binding]; other site
1229492000692	FAD binding motif [chemical binding]; other site
1229492000693	phosphate binding motif [ion binding]; other site
1229492000694	beta-alpha-beta structure motif; other site
1229492000695	NAD binding pocket [chemical binding]; other site
1229492000696	Heme binding  pocket [chemical binding]; other site
1229492000697	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1229492000698	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1229492000699	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229492000700	NAD binding site [chemical binding]; other site
1229492000701	dimer interface [polypeptide binding]; other site
1229492000702	substrate binding site [chemical binding]; other site
1229492000703	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1229492000704	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492000705	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492000706	active site turn [active]
1229492000707	phosphorylation site [posttranslational modification]
1229492000708	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1229492000709	active site
1229492000710	tetramer interface [polypeptide binding]; other site
1229492000711	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1229492000712	Mga helix-turn-helix domain; Region: Mga; pfam05043
1229492000713	PRD domain; Region: PRD; pfam00874
1229492000714	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1229492000715	active site
1229492000716	P-loop; other site
1229492000717	phosphorylation site [posttranslational modification]
1229492000718	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492000719	active site
1229492000720	phosphorylation site [posttranslational modification]
1229492000721	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492000722	active site
1229492000723	phosphorylation site [posttranslational modification]
1229492000724	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1229492000725	active site
1229492000726	P-loop; other site
1229492000727	phosphorylation site [posttranslational modification]
1229492000728	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1229492000729	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1229492000730	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229492000731	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1229492000732	putative NAD(P) binding site [chemical binding]; other site
1229492000733	catalytic Zn binding site [ion binding]; other site
1229492000734	structural Zn binding site [ion binding]; other site
1229492000735	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229492000736	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1229492000737	putative NAD(P) binding site [chemical binding]; other site
1229492000738	catalytic Zn binding site [ion binding]; other site
1229492000739	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1229492000740	substrate binding site; other site
1229492000741	dimer interface; other site
1229492000742	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1229492000743	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229492000744	putative NAD(P) binding site [chemical binding]; other site
1229492000745	putative catalytic Zn binding site [ion binding]; other site
1229492000746	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229492000747	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229492000748	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229492000749	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229492000750	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1229492000751	substrate binding site; other site
1229492000752	dimer interface; other site
1229492000753	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1229492000754	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229492000755	putative NAD(P) binding site [chemical binding]; other site
1229492000756	putative catalytic Zn binding site [ion binding]; other site
1229492000757	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229492000758	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229492000759	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229492000760	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229492000761	active site
1229492000762	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
1229492000763	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1229492000764	Hemerythrin-like domain; Region: Hr-like; cd12108
1229492000765	Fe binding site [ion binding]; other site
1229492000766	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1229492000767	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1229492000768	Histidine kinase; Region: His_kinase; pfam06580
1229492000769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492000770	Mg2+ binding site [ion binding]; other site
1229492000771	G-X-G motif; other site
1229492000772	two-component response regulator; Provisional; Region: PRK14084
1229492000773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492000774	active site
1229492000775	phosphorylation site [posttranslational modification]
1229492000776	intermolecular recognition site; other site
1229492000777	dimerization interface [polypeptide binding]; other site
1229492000778	LytTr DNA-binding domain; Region: LytTR; pfam04397
1229492000779	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1229492000780	antiholin-like protein LrgB; Provisional; Region: PRK04288
1229492000781	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
1229492000782	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
1229492000783	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229492000784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229492000785	DNA-binding site [nucleotide binding]; DNA binding site
1229492000786	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1229492000787	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1229492000788	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1229492000789	HPr interaction site; other site
1229492000790	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229492000791	active site
1229492000792	phosphorylation site [posttranslational modification]
1229492000793	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1229492000794	beta-galactosidase; Region: BGL; TIGR03356
1229492000795	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229492000796	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492000797	S-adenosylmethionine binding site [chemical binding]; other site
1229492000798	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229492000799	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1229492000800	substrate binding site [chemical binding]; other site
1229492000801	dimer interface [polypeptide binding]; other site
1229492000802	ATP binding site [chemical binding]; other site
1229492000803	D-ribose pyranase; Provisional; Region: PRK11797
1229492000804	Sugar transport protein; Region: Sugar_transport; pfam06800
1229492000805	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229492000806	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229492000807	DNA binding site [nucleotide binding]
1229492000808	domain linker motif; other site
1229492000809	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1229492000810	dimerization interface [polypeptide binding]; other site
1229492000811	ligand binding site [chemical binding]; other site
1229492000812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492000814	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1229492000815	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1229492000816	active site
1229492000817	Surface antigen [General function prediction only]; Region: COG3942
1229492000818	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1229492000819	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229492000820	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229492000821	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1229492000822	Walker A/P-loop; other site
1229492000823	ATP binding site [chemical binding]; other site
1229492000824	Q-loop/lid; other site
1229492000825	ABC transporter signature motif; other site
1229492000826	Walker B; other site
1229492000827	D-loop; other site
1229492000828	H-loop/switch region; other site
1229492000829	Surface antigen [General function prediction only]; Region: COG3942
1229492000830	CHAP domain; Region: CHAP; pfam05257
1229492000831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1229492000832	Predicted membrane protein [Function unknown]; Region: COG1511
1229492000833	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229492000834	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1229492000835	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
1229492000836	Uncharacterized small protein [Function unknown]; Region: COG5417
1229492000837	Predicted membrane protein [Function unknown]; Region: COG4499
1229492000838	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1229492000839	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1229492000840	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1229492000841	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229492000842	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229492000843	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1229492000844	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
1229492000845	LXG domain of WXG superfamily; Region: LXG; pfam04740
1229492000846	Protein of unknown function, DUF600; Region: DUF600; cl04640
1229492000847	Protein of unknown function, DUF600; Region: DUF600; cl04640
1229492000848	Protein of unknown function, DUF600; Region: DUF600; cl04640
1229492000849	Protein of unknown function, DUF600; Region: DUF600; cl04640
1229492000850	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1229492000851	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1229492000852	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1229492000853	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1229492000854	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229492000855	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229492000856	FtsX-like permease family; Region: FtsX; pfam02687
1229492000857	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229492000858	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229492000859	Walker A/P-loop; other site
1229492000860	ATP binding site [chemical binding]; other site
1229492000861	Q-loop/lid; other site
1229492000862	ABC transporter signature motif; other site
1229492000863	Walker B; other site
1229492000864	D-loop; other site
1229492000865	H-loop/switch region; other site
1229492000866	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229492000867	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1229492000868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492000869	non-specific DNA binding site [nucleotide binding]; other site
1229492000870	salt bridge; other site
1229492000871	sequence-specific DNA binding site [nucleotide binding]; other site
1229492000872	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229492000873	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1229492000874	substrate binding site [chemical binding]; other site
1229492000875	ATP binding site [chemical binding]; other site
1229492000876	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1229492000877	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1229492000878	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1229492000879	Nucleoside recognition; Region: Gate; pfam07670
1229492000880	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1229492000881	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1229492000882	putative transporter; Provisional; Region: PRK10484
1229492000883	Na binding site [ion binding]; other site
1229492000884	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1229492000885	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1229492000886	inhibitor site; inhibition site
1229492000887	active site
1229492000888	dimer interface [polypeptide binding]; other site
1229492000889	catalytic residue [active]
1229492000890	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1229492000891	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229492000892	nucleotide binding site [chemical binding]; other site
1229492000893	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1229492000894	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229492000895	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229492000896	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229492000897	putative active site [active]
1229492000898	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1229492000899	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1229492000900	putative active site cavity [active]
1229492000901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1229492000902	Nucleoside recognition; Region: Gate; pfam07670
1229492000903	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1229492000904	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1229492000905	Int/Topo IB signature motif; other site
1229492000906	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1229492000907	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229492000908	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492000909	non-specific DNA binding site [nucleotide binding]; other site
1229492000910	salt bridge; other site
1229492000911	sequence-specific DNA binding site [nucleotide binding]; other site
1229492000912	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229492000913	non-specific DNA binding site [nucleotide binding]; other site
1229492000914	salt bridge; other site
1229492000915	sequence-specific DNA binding site [nucleotide binding]; other site
1229492000916	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1229492000917	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
1229492000918	Homeodomain-like domain; Region: HTH_23; pfam13384
1229492000919	Protein of unknown function (DUF1270); Region: DUF1270; pfam06900
1229492000920	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1229492000921	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
1229492000922	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
1229492000923	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
1229492000924	active site
1229492000925	DNA binding site [nucleotide binding]
1229492000926	catalytic site [active]
1229492000927	Protein of unknown function (DUF3113); Region: DUF3113; pfam11310
1229492000928	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
1229492000929	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
1229492000930	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
1229492000931	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
1229492000932	Transcriptional activator RinB; Region: RinB; pfam06116
1229492000933	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
1229492000934	Virulence-associated protein E; Region: VirE; pfam05272
1229492000935	VRR-NUC domain; Region: VRR_NUC; pfam08774
1229492000936	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1229492000937	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492000938	ATP binding site [chemical binding]; other site
1229492000939	putative Mg++ binding site [ion binding]; other site
1229492000940	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1229492000941	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1229492000942	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1229492000943	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1229492000944	active site
1229492000945	Phage terminase, small subunit; Region: Terminase_4; pfam05119
1229492000946	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1229492000947	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1229492000948	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1229492000949	Clp protease; Region: CLP_protease; pfam00574
1229492000950	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1229492000951	oligomer interface [polypeptide binding]; other site
1229492000952	active site residues [active]
1229492000953	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1229492000954	Phage capsid family; Region: Phage_capsid; pfam05065
1229492000955	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1229492000956	oligomerization interface [polypeptide binding]; other site
1229492000957	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1229492000958	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1229492000959	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1229492000960	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
1229492000961	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
1229492000962	linker region; other site
1229492000963	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1229492000964	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1229492000965	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229492000966	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229492000967	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229492000968	catalytic residue [active]
1229492000969	Phage tail protein; Region: Sipho_tail; pfam05709
1229492000970	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
1229492000971	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1229492000972	hypothetical protein; Provisional; Region: PRK05926
1229492000973	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
1229492000974	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
1229492000975	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
1229492000976	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
1229492000977	holin, SPP1 family; Region: holin_SPP1; TIGR01592
1229492000978	CHAP domain; Region: CHAP; pfam05257
1229492000979	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1229492000980	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1229492000981	active site
1229492000982	metal binding site [ion binding]; metal-binding site
1229492000983	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1229492000984	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1229492000985	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229492000986	phosphate binding site [ion binding]; other site
1229492000987	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229492000988	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1229492000989	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1229492000990	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1229492000991	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1229492000992	lipoyl attachment site [posttranslational modification]; other site
1229492000993	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1229492000994	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1229492000995	putative ADP-ribose binding site [chemical binding]; other site
1229492000996	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1229492000997	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1229492000998	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1229492000999	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1229492001000	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1229492001001	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229492001002	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1229492001003	NADP binding site [chemical binding]; other site
1229492001004	putative substrate binding site [chemical binding]; other site
1229492001005	active site
1229492001006	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1229492001007	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1229492001008	active site
1229492001009	P-loop; other site
1229492001010	phosphorylation site [posttranslational modification]
1229492001011	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492001012	active site
1229492001013	phosphorylation site [posttranslational modification]
1229492001014	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1229492001015	HTH domain; Region: HTH_11; pfam08279
1229492001016	HTH domain; Region: HTH_11; pfam08279
1229492001017	PRD domain; Region: PRD; pfam00874
1229492001018	PRD domain; Region: PRD; pfam00874
1229492001019	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1229492001020	active site
1229492001021	P-loop; other site
1229492001022	phosphorylation site [posttranslational modification]
1229492001023	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492001024	active site
1229492001025	phosphorylation site [posttranslational modification]
1229492001026	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492001027	MarR family; Region: MarR_2; pfam12802
1229492001028	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1229492001029	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1229492001030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
1229492001031	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1229492001032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492001033	putative substrate translocation pore; other site
1229492001034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492001035	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1229492001036	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229492001037	Zn binding site [ion binding]; other site
1229492001038	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1229492001039	Zn binding site [ion binding]; other site
1229492001040	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1229492001041	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1229492001042	Predicted flavoprotein [General function prediction only]; Region: COG0431
1229492001043	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229492001044	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
1229492001045	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1229492001046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229492001047	Imelysin; Region: Peptidase_M75; pfam09375
1229492001048	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1229492001049	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1229492001050	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1229492001051	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1229492001052	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1229492001053	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
1229492001054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492001055	non-specific DNA binding site [nucleotide binding]; other site
1229492001056	salt bridge; other site
1229492001057	sequence-specific DNA binding site [nucleotide binding]; other site
1229492001058	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1229492001059	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229492001060	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229492001061	Walker A/P-loop; other site
1229492001062	ATP binding site [chemical binding]; other site
1229492001063	Q-loop/lid; other site
1229492001064	ABC transporter signature motif; other site
1229492001065	Walker B; other site
1229492001066	D-loop; other site
1229492001067	H-loop/switch region; other site
1229492001068	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1229492001069	Predicted membrane protein [Function unknown]; Region: COG4292
1229492001070	putative acyltransferase; Provisional; Region: PRK05790
1229492001071	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229492001072	dimer interface [polypeptide binding]; other site
1229492001073	active site
1229492001074	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1229492001075	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1229492001076	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1229492001077	THF binding site; other site
1229492001078	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1229492001079	substrate binding site [chemical binding]; other site
1229492001080	THF binding site; other site
1229492001081	zinc-binding site [ion binding]; other site
1229492001082	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1229492001083	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1229492001084	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1229492001085	FAD binding site [chemical binding]; other site
1229492001086	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1229492001087	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229492001088	homodimer interface [polypeptide binding]; other site
1229492001089	substrate-cofactor binding pocket; other site
1229492001090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492001091	catalytic residue [active]
1229492001092	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1229492001093	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229492001094	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492001095	catalytic residue [active]
1229492001096	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1229492001097	ParB-like nuclease domain; Region: ParB; smart00470
1229492001098	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1229492001099	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1229492001100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
1229492001101	GTP-binding protein YchF; Reviewed; Region: PRK09601
1229492001102	YchF GTPase; Region: YchF; cd01900
1229492001103	G1 box; other site
1229492001104	GTP/Mg2+ binding site [chemical binding]; other site
1229492001105	Switch I region; other site
1229492001106	G2 box; other site
1229492001107	Switch II region; other site
1229492001108	G3 box; other site
1229492001109	G4 box; other site
1229492001110	G5 box; other site
1229492001111	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1229492001112	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1229492001113	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1229492001114	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1229492001115	dimer interface [polypeptide binding]; other site
1229492001116	ssDNA binding site [nucleotide binding]; other site
1229492001117	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229492001118	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1229492001119	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1229492001121	Predicted membrane protein [Function unknown]; Region: COG3212
1229492001122	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1229492001123	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229492001124	non-specific DNA binding site [nucleotide binding]; other site
1229492001125	salt bridge; other site
1229492001126	sequence-specific DNA binding site [nucleotide binding]; other site
1229492001127	Predicted membrane protein [Function unknown]; Region: COG2261
1229492001128	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229492001129	catalytic core [active]
1229492001130	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1229492001131	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1229492001132	catalytic residue [active]
1229492001133	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1229492001134	catalytic residues [active]
1229492001135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492001136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492001137	peroxiredoxin; Region: AhpC; TIGR03137
1229492001138	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1229492001139	dimer interface [polypeptide binding]; other site
1229492001140	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1229492001141	catalytic triad [active]
1229492001142	peroxidatic and resolving cysteines [active]
1229492001143	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1229492001144	dimer interface [polypeptide binding]; other site
1229492001145	FMN binding site [chemical binding]; other site
1229492001146	NADPH bind site [chemical binding]; other site
1229492001147	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1229492001148	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229492001149	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492001150	active site
1229492001151	xanthine permease; Region: pbuX; TIGR03173
1229492001152	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1229492001153	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229492001154	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1229492001155	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1229492001156	active site
1229492001157	GMP synthase; Reviewed; Region: guaA; PRK00074
1229492001158	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1229492001159	AMP/PPi binding site [chemical binding]; other site
1229492001160	candidate oxyanion hole; other site
1229492001161	catalytic triad [active]
1229492001162	potential glutamine specificity residues [chemical binding]; other site
1229492001163	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1229492001164	ATP Binding subdomain [chemical binding]; other site
1229492001165	Ligand Binding sites [chemical binding]; other site
1229492001166	Dimerization subdomain; other site
1229492001167	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1229492001168	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1229492001169	Int/Topo IB signature motif; other site
1229492001170	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229492001171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492001172	non-specific DNA binding site [nucleotide binding]; other site
1229492001173	salt bridge; other site
1229492001174	sequence-specific DNA binding site [nucleotide binding]; other site
1229492001175	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492001176	non-specific DNA binding site [nucleotide binding]; other site
1229492001177	salt bridge; other site
1229492001178	sequence-specific DNA binding site [nucleotide binding]; other site
1229492001179	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
1229492001180	Uncharacterized conserved protein [Function unknown]; Region: COG4983
1229492001181	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943
1229492001182	nucleotide binding site [chemical binding]; other site
1229492001183	D5 N terminal like; Region: D5_N; smart00885
1229492001184	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1229492001185	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
1229492001186	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1229492001187	adenosine deaminase; Provisional; Region: PRK09358
1229492001188	active site
1229492001189	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1229492001190	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1229492001191	PemK-like protein; Region: PemK; pfam02452
1229492001192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229492001193	Transposase; Region: HTH_Tnp_1; cl17663
1229492001194	Predicted membrane protein [Function unknown]; Region: COG3759
1229492001195	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1229492001196	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1229492001197	NADP binding site [chemical binding]; other site
1229492001198	superantigen-like protein; Reviewed; Region: PRK13037
1229492001199	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001200	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001201	superantigen-like protein; Reviewed; Region: PRK13041
1229492001202	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001203	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001204	superantigen-like protein; Reviewed; Region: PRK13335
1229492001205	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001206	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001207	superantigen-like protein; Reviewed; Region: PRK13335
1229492001208	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001209	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001210	superantigen-like protein 5; Reviewed; Region: PRK13035
1229492001211	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001212	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001213	superantigen-like protein 7; Reviewed; Region: PRK13346
1229492001214	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001215	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001216	superantigen-like protein; Reviewed; Region: PRK13345
1229492001217	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001218	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001219	superantigen-like protein; Reviewed; Region: PRK13038
1229492001220	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001221	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001222	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1229492001223	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1229492001224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492001225	S-adenosylmethionine binding site [chemical binding]; other site
1229492001226	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1229492001227	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1229492001228	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1229492001229	superantigen-like protein; Reviewed; Region: PRK13036
1229492001230	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1229492001231	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492001232	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492001233	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492001234	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492001235	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492001236	Protein of unknown function, DUF576; Region: DUF576; cl04553
1229492001237	Protein of unknown function, DUF576; Region: DUF576; cl04553
1229492001238	Protein of unknown function, DUF576; Region: DUF576; cl04553
1229492001239	Protein of unknown function, DUF576; Region: DUF576; cl04553
1229492001240	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492001241	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1229492001242	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1229492001243	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1229492001244	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1229492001245	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229492001246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1229492001247	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1229492001248	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
1229492001249	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1229492001250	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229492001251	active site
1229492001252	Esterase/lipase [General function prediction only]; Region: COG1647
1229492001253	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229492001254	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1229492001255	Na2 binding site [ion binding]; other site
1229492001256	putative substrate binding site 1 [chemical binding]; other site
1229492001257	Na binding site 1 [ion binding]; other site
1229492001258	putative substrate binding site 2 [chemical binding]; other site
1229492001259	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1229492001260	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1229492001261	dimer interface [polypeptide binding]; other site
1229492001262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492001263	catalytic residue [active]
1229492001264	cystathionine beta-lyase; Provisional; Region: PRK07671
1229492001265	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229492001266	homodimer interface [polypeptide binding]; other site
1229492001267	substrate-cofactor binding pocket; other site
1229492001268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492001269	catalytic residue [active]
1229492001270	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1229492001271	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1229492001272	Walker A/P-loop; other site
1229492001273	ATP binding site [chemical binding]; other site
1229492001274	Q-loop/lid; other site
1229492001275	ABC transporter signature motif; other site
1229492001276	Walker B; other site
1229492001277	D-loop; other site
1229492001278	H-loop/switch region; other site
1229492001279	NIL domain; Region: NIL; pfam09383
1229492001280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492001281	dimer interface [polypeptide binding]; other site
1229492001282	conserved gate region; other site
1229492001283	ABC-ATPase subunit interface; other site
1229492001284	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229492001285	LysM domain; Region: LysM; pfam01476
1229492001286	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492001287	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492001288	Surface antigen [General function prediction only]; Region: COG3942
1229492001289	CHAP domain; Region: CHAP; pfam05257
1229492001290	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1229492001291	nudix motif; other site
1229492001292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492001293	Coenzyme A binding pocket [chemical binding]; other site
1229492001294	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1229492001295	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1229492001296	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229492001297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229492001298	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229492001299	dimerization interface [polypeptide binding]; other site
1229492001300	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1229492001301	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1229492001302	active site
1229492001303	dimer interface [polypeptide binding]; other site
1229492001304	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1229492001305	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1229492001306	active site
1229492001307	FMN binding site [chemical binding]; other site
1229492001308	substrate binding site [chemical binding]; other site
1229492001309	3Fe-4S cluster binding site [ion binding]; other site
1229492001310	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1229492001311	domain interface; other site
1229492001312	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1229492001313	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229492001314	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1229492001315	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492001316	active site turn [active]
1229492001317	phosphorylation site [posttranslational modification]
1229492001318	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492001319	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229492001320	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1229492001321	Ca binding site [ion binding]; other site
1229492001322	active site
1229492001323	catalytic site [active]
1229492001324	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1229492001325	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229492001326	DNA-binding site [nucleotide binding]; DNA binding site
1229492001327	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1229492001328	UTRA domain; Region: UTRA; pfam07702
1229492001329	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229492001330	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492001331	Coenzyme A binding pocket [chemical binding]; other site
1229492001332	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1229492001333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492001334	Walker A motif; other site
1229492001335	ATP binding site [chemical binding]; other site
1229492001336	Walker B motif; other site
1229492001337	arginine finger; other site
1229492001338	hypothetical protein; Validated; Region: PRK00153
1229492001339	recombination protein RecR; Reviewed; Region: recR; PRK00076
1229492001340	RecR protein; Region: RecR; pfam02132
1229492001341	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1229492001342	putative active site [active]
1229492001343	putative metal-binding site [ion binding]; other site
1229492001344	tetramer interface [polypeptide binding]; other site
1229492001345	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1229492001346	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229492001347	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492001348	catalytic residue [active]
1229492001349	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1229492001350	thymidylate kinase; Validated; Region: tmk; PRK00698
1229492001351	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1229492001352	TMP-binding site; other site
1229492001353	ATP-binding site [chemical binding]; other site
1229492001354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
1229492001355	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1229492001356	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1229492001357	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1229492001358	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
1229492001359	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1229492001360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492001361	S-adenosylmethionine binding site [chemical binding]; other site
1229492001362	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1229492001363	GIY-YIG motif/motif A; other site
1229492001364	putative active site [active]
1229492001365	putative metal binding site [ion binding]; other site
1229492001366	Predicted methyltransferases [General function prediction only]; Region: COG0313
1229492001367	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1229492001368	putative SAM binding site [chemical binding]; other site
1229492001369	putative homodimer interface [polypeptide binding]; other site
1229492001370	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1229492001371	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1229492001372	active site
1229492001373	HIGH motif; other site
1229492001374	KMSKS motif; other site
1229492001375	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1229492001376	tRNA binding surface [nucleotide binding]; other site
1229492001377	anticodon binding site; other site
1229492001378	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1229492001379	dimer interface [polypeptide binding]; other site
1229492001380	putative tRNA-binding site [nucleotide binding]; other site
1229492001381	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1229492001382	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1229492001383	active site
1229492001384	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1229492001385	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1229492001386	putative active site [active]
1229492001387	putative metal binding site [ion binding]; other site
1229492001388	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1229492001389	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1229492001390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492001391	S-adenosylmethionine binding site [chemical binding]; other site
1229492001392	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1229492001393	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1229492001394	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229492001395	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1229492001396	pur operon repressor; Provisional; Region: PRK09213
1229492001397	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1229492001398	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492001399	active site
1229492001400	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229492001401	homotrimer interaction site [polypeptide binding]; other site
1229492001402	putative active site [active]
1229492001403	regulatory protein SpoVG; Reviewed; Region: PRK13259
1229492001404	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1229492001405	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1229492001406	Substrate binding site; other site
1229492001407	Mg++ binding site; other site
1229492001408	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1229492001409	active site
1229492001410	substrate binding site [chemical binding]; other site
1229492001411	CoA binding site [chemical binding]; other site
1229492001412	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1229492001413	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1229492001414	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492001415	active site
1229492001416	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1229492001417	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1229492001418	5S rRNA interface [nucleotide binding]; other site
1229492001419	CTC domain interface [polypeptide binding]; other site
1229492001420	L16 interface [polypeptide binding]; other site
1229492001421	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1229492001422	putative active site [active]
1229492001423	catalytic residue [active]
1229492001424	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1229492001425	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1229492001426	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492001427	ATP binding site [chemical binding]; other site
1229492001428	putative Mg++ binding site [ion binding]; other site
1229492001429	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492001430	nucleotide binding region [chemical binding]; other site
1229492001431	ATP-binding site [chemical binding]; other site
1229492001432	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1229492001433	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229492001434	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1229492001435	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1229492001436	putative SAM binding site [chemical binding]; other site
1229492001437	putative homodimer interface [polypeptide binding]; other site
1229492001438	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1229492001439	homodimer interface [polypeptide binding]; other site
1229492001440	metal binding site [ion binding]; metal-binding site
1229492001441	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492001442	RNA binding surface [nucleotide binding]; other site
1229492001443	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1229492001444	Septum formation initiator; Region: DivIC; pfam04977
1229492001445	hypothetical protein; Provisional; Region: PRK08582
1229492001446	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1229492001447	RNA binding site [nucleotide binding]; other site
1229492001448	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1229492001449	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1229492001450	Ligand Binding Site [chemical binding]; other site
1229492001451	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1229492001452	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492001453	active site
1229492001454	FtsH Extracellular; Region: FtsH_ext; pfam06480
1229492001455	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1229492001456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492001457	Walker A motif; other site
1229492001458	ATP binding site [chemical binding]; other site
1229492001459	Walker B motif; other site
1229492001460	arginine finger; other site
1229492001461	Peptidase family M41; Region: Peptidase_M41; pfam01434
1229492001462	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1229492001463	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1229492001464	dimerization interface [polypeptide binding]; other site
1229492001465	domain crossover interface; other site
1229492001466	redox-dependent activation switch; other site
1229492001467	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1229492001468	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1229492001469	dimer interface [polypeptide binding]; other site
1229492001470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492001471	catalytic residue [active]
1229492001472	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1229492001473	dihydropteroate synthase; Region: DHPS; TIGR01496
1229492001474	substrate binding pocket [chemical binding]; other site
1229492001475	dimer interface [polypeptide binding]; other site
1229492001476	inhibitor binding site; inhibition site
1229492001477	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1229492001478	homooctamer interface [polypeptide binding]; other site
1229492001479	active site
1229492001480	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1229492001481	catalytic center binding site [active]
1229492001482	ATP binding site [chemical binding]; other site
1229492001483	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1229492001484	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1229492001485	dimer interface [polypeptide binding]; other site
1229492001486	putative anticodon binding site; other site
1229492001487	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1229492001488	motif 1; other site
1229492001489	active site
1229492001490	motif 2; other site
1229492001491	motif 3; other site
1229492001492	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229492001493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229492001494	DNA-binding site [nucleotide binding]; DNA binding site
1229492001495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229492001496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492001497	homodimer interface [polypeptide binding]; other site
1229492001498	catalytic residue [active]
1229492001499	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1229492001500	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1229492001501	active site
1229492001502	multimer interface [polypeptide binding]; other site
1229492001503	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1229492001504	predicted active site [active]
1229492001505	catalytic triad [active]
1229492001506	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1229492001507	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1229492001508	Nucleoside recognition; Region: Gate; pfam07670
1229492001509	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1229492001510	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1229492001511	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1229492001512	UvrB/uvrC motif; Region: UVR; pfam02151
1229492001513	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
1229492001514	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1229492001515	ADP binding site [chemical binding]; other site
1229492001516	phosphagen binding site; other site
1229492001517	substrate specificity loop; other site
1229492001518	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1229492001519	Clp amino terminal domain; Region: Clp_N; pfam02861
1229492001520	Clp amino terminal domain; Region: Clp_N; pfam02861
1229492001521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492001522	Walker A motif; other site
1229492001523	ATP binding site [chemical binding]; other site
1229492001524	Walker B motif; other site
1229492001525	arginine finger; other site
1229492001526	UvrB/uvrC motif; Region: UVR; pfam02151
1229492001527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492001528	Walker A motif; other site
1229492001529	ATP binding site [chemical binding]; other site
1229492001530	Walker B motif; other site
1229492001531	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1229492001532	DNA repair protein RadA; Provisional; Region: PRK11823
1229492001533	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1229492001534	Walker A motif/ATP binding site; other site
1229492001535	ATP binding site [chemical binding]; other site
1229492001536	Walker B motif; other site
1229492001537	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1229492001538	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1229492001539	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1229492001540	putative active site [active]
1229492001541	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1229492001542	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1229492001543	active site
1229492001544	HIGH motif; other site
1229492001545	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1229492001546	active site
1229492001547	KMSKS motif; other site
1229492001548	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1229492001549	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1229492001550	trimer interface [polypeptide binding]; other site
1229492001551	active site
1229492001552	substrate binding site [chemical binding]; other site
1229492001553	CoA binding site [chemical binding]; other site
1229492001554	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1229492001555	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1229492001556	active site
1229492001557	HIGH motif; other site
1229492001558	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1229492001559	KMSKS motif; other site
1229492001560	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1229492001561	tRNA binding surface [nucleotide binding]; other site
1229492001562	anticodon binding site; other site
1229492001563	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1229492001564	active site
1229492001565	dimerization interface [polypeptide binding]; other site
1229492001566	metal binding site [ion binding]; metal-binding site
1229492001567	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1229492001568	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1229492001569	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1229492001570	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1229492001571	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1229492001572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229492001573	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1229492001574	DNA binding residues [nucleotide binding]
1229492001575	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1229492001576	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1229492001577	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1229492001578	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1229492001579	putative homodimer interface [polypeptide binding]; other site
1229492001580	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1229492001581	heterodimer interface [polypeptide binding]; other site
1229492001582	homodimer interface [polypeptide binding]; other site
1229492001583	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1229492001584	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1229492001585	23S rRNA interface [nucleotide binding]; other site
1229492001586	L7/L12 interface [polypeptide binding]; other site
1229492001587	putative thiostrepton binding site; other site
1229492001588	L25 interface [polypeptide binding]; other site
1229492001589	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1229492001590	mRNA/rRNA interface [nucleotide binding]; other site
1229492001591	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1229492001592	23S rRNA interface [nucleotide binding]; other site
1229492001593	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1229492001594	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1229492001595	peripheral dimer interface [polypeptide binding]; other site
1229492001596	core dimer interface [polypeptide binding]; other site
1229492001597	L10 interface [polypeptide binding]; other site
1229492001598	L11 interface [polypeptide binding]; other site
1229492001599	putative EF-Tu interaction site [polypeptide binding]; other site
1229492001600	putative EF-G interaction site [polypeptide binding]; other site
1229492001601	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229492001602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492001603	S-adenosylmethionine binding site [chemical binding]; other site
1229492001604	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1229492001605	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1229492001606	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1229492001607	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1229492001608	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1229492001609	RPB10 interaction site [polypeptide binding]; other site
1229492001610	RPB1 interaction site [polypeptide binding]; other site
1229492001611	RPB11 interaction site [polypeptide binding]; other site
1229492001612	RPB3 interaction site [polypeptide binding]; other site
1229492001613	RPB12 interaction site [polypeptide binding]; other site
1229492001614	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1229492001615	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1229492001616	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1229492001617	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1229492001618	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1229492001619	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1229492001620	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1229492001621	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1229492001622	G-loop; other site
1229492001623	DNA binding site [nucleotide binding]
1229492001624	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
1229492001625	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1229492001626	S17 interaction site [polypeptide binding]; other site
1229492001627	S8 interaction site; other site
1229492001628	16S rRNA interaction site [nucleotide binding]; other site
1229492001629	streptomycin interaction site [chemical binding]; other site
1229492001630	23S rRNA interaction site [nucleotide binding]; other site
1229492001631	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1229492001632	30S ribosomal protein S7; Validated; Region: PRK05302
1229492001633	elongation factor G; Reviewed; Region: PRK00007
1229492001634	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1229492001635	G1 box; other site
1229492001636	putative GEF interaction site [polypeptide binding]; other site
1229492001637	GTP/Mg2+ binding site [chemical binding]; other site
1229492001638	Switch I region; other site
1229492001639	G2 box; other site
1229492001640	G3 box; other site
1229492001641	Switch II region; other site
1229492001642	G4 box; other site
1229492001643	G5 box; other site
1229492001644	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1229492001645	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1229492001646	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1229492001647	elongation factor Tu; Reviewed; Region: PRK00049
1229492001648	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1229492001649	G1 box; other site
1229492001650	GEF interaction site [polypeptide binding]; other site
1229492001651	GTP/Mg2+ binding site [chemical binding]; other site
1229492001652	Switch I region; other site
1229492001653	G2 box; other site
1229492001654	G3 box; other site
1229492001655	Switch II region; other site
1229492001656	G4 box; other site
1229492001657	G5 box; other site
1229492001658	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1229492001659	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1229492001660	Antibiotic Binding Site [chemical binding]; other site
1229492001661	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229492001662	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1229492001663	metal binding site [ion binding]; metal-binding site
1229492001664	dimer interface [polypeptide binding]; other site
1229492001665	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1229492001666	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1229492001667	substrate-cofactor binding pocket; other site
1229492001668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492001669	catalytic residue [active]
1229492001670	chaperone protein HchA; Provisional; Region: PRK04155
1229492001671	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229492001672	conserved cys residue [active]
1229492001673	ribulokinase; Provisional; Region: PRK04123
1229492001674	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1229492001675	N- and C-terminal domain interface [polypeptide binding]; other site
1229492001676	active site
1229492001677	MgATP binding site [chemical binding]; other site
1229492001678	catalytic site [active]
1229492001679	metal binding site [ion binding]; metal-binding site
1229492001680	carbohydrate binding site [chemical binding]; other site
1229492001681	homodimer interface [polypeptide binding]; other site
1229492001682	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229492001683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492001684	NAD(P) binding site [chemical binding]; other site
1229492001685	active site
1229492001686	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1229492001687	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1229492001688	homodimer interface [polypeptide binding]; other site
1229492001689	substrate-cofactor binding pocket; other site
1229492001690	catalytic residue [active]
1229492001691	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1229492001692	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492001693	motif II; other site
1229492001694	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1229492001695	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1229492001696	Substrate-binding site [chemical binding]; other site
1229492001697	Substrate specificity [chemical binding]; other site
1229492001698	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1229492001699	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1229492001700	Substrate-binding site [chemical binding]; other site
1229492001701	Substrate specificity [chemical binding]; other site
1229492001702	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1229492001703	nucleoside/Zn binding site; other site
1229492001704	dimer interface [polypeptide binding]; other site
1229492001705	catalytic motif [active]
1229492001706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492001707	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1229492001708	active site
1229492001709	motif I; other site
1229492001710	motif II; other site
1229492001711	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492001712	Predicted flavoprotein [General function prediction only]; Region: COG0431
1229492001713	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229492001714	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492001715	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492001716	Cna protein B-type domain; Region: Cna_B; pfam05738
1229492001717	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1229492001718	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492001719	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492001720	Cna protein B-type domain; Region: Cna_B; pfam05738
1229492001721	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1229492001722	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1229492001723	Cna protein B-type domain; Region: Cna_B; pfam05738
1229492001724	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1229492001725	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1229492001726	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492001727	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492001728	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1229492001729	Cna protein B-type domain; Region: Cna_B; pfam05738
1229492001730	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1229492001731	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1229492001732	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1229492001733	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229492001734	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1229492001735	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1229492001736	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229492001737	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1229492001738	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1229492001739	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1229492001740	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1229492001741	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1229492001742	active site
1229492001743	trimer interface [polypeptide binding]; other site
1229492001744	allosteric site; other site
1229492001745	active site lid [active]
1229492001746	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1229492001747	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1229492001748	active site
1229492001749	dimer interface [polypeptide binding]; other site
1229492001750	magnesium binding site [ion binding]; other site
1229492001751	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1229492001752	tetramer interface [polypeptide binding]; other site
1229492001753	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229492001754	active site
1229492001755	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1229492001756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492001757	motif II; other site
1229492001758	proline/glycine betaine transporter; Provisional; Region: PRK10642
1229492001759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492001760	putative substrate translocation pore; other site
1229492001761	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1229492001762	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1229492001763	acyl-activating enzyme (AAE) consensus motif; other site
1229492001764	AMP binding site [chemical binding]; other site
1229492001765	active site
1229492001766	CoA binding site [chemical binding]; other site
1229492001767	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229492001768	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1229492001769	dimer interface [polypeptide binding]; other site
1229492001770	active site
1229492001771	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229492001772	dimer interface [polypeptide binding]; other site
1229492001773	substrate binding site [chemical binding]; other site
1229492001774	ATP binding site [chemical binding]; other site
1229492001775	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1229492001776	ligand binding site [chemical binding]; other site
1229492001777	active site
1229492001778	UGI interface [polypeptide binding]; other site
1229492001779	catalytic site [active]
1229492001780	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1229492001781	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1229492001782	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1229492001783	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1229492001784	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1229492001785	putative heme peroxidase; Provisional; Region: PRK12276
1229492001786	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1229492001787	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1229492001788	mevalonate kinase; Region: mevalon_kin; TIGR00549
1229492001789	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229492001790	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1229492001791	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1229492001792	diphosphomevalonate decarboxylase; Region: PLN02407
1229492001793	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1229492001794	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229492001795	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1229492001796	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1229492001797	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1229492001798	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229492001799	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492001800	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229492001801	Predicted transcriptional regulator [Transcription]; Region: COG1959
1229492001802	Transcriptional regulator; Region: Rrf2; pfam02082
1229492001803	LXG domain of WXG superfamily; Region: LXG; pfam04740
1229492001804	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001805	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001806	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001807	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001808	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001809	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001810	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001811	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001812	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1229492001813	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229492001814	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229492001815	active site
1229492001816	catalytic tetrad [active]
1229492001817	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1229492001818	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229492001819	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229492001820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492001821	Coenzyme A binding pocket [chemical binding]; other site
1229492001822	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1229492001823	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229492001824	Zn2+ binding site [ion binding]; other site
1229492001825	Mg2+ binding site [ion binding]; other site
1229492001826	YwhD family; Region: YwhD; pfam08741
1229492001827	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1229492001828	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1229492001829	NAD binding site [chemical binding]; other site
1229492001830	substrate binding site [chemical binding]; other site
1229492001831	catalytic Zn binding site [ion binding]; other site
1229492001832	tetramer interface [polypeptide binding]; other site
1229492001833	structural Zn binding site [ion binding]; other site
1229492001834	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
1229492001835	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1229492001836	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1229492001837	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1229492001838	active site
1229492001839	HIGH motif; other site
1229492001840	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229492001841	KMSK motif region; other site
1229492001842	tRNA binding surface [nucleotide binding]; other site
1229492001843	DALR anticodon binding domain; Region: DALR_1; smart00836
1229492001844	anticodon binding site; other site
1229492001845	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1229492001846	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229492001847	minor groove reading motif; other site
1229492001848	helix-hairpin-helix signature motif; other site
1229492001849	substrate binding pocket [chemical binding]; other site
1229492001850	active site
1229492001851	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1229492001852	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1229492001853	putative binding site residues; other site
1229492001854	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1229492001855	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492001856	ABC-ATPase subunit  interface; other site
1229492001857	dimer interface [polypeptide binding]; other site
1229492001858	putative PBP binding regions; other site
1229492001859	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1229492001860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492001861	motif II; other site
1229492001862	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229492001863	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229492001864	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229492001865	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229492001866	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492001867	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229492001868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1229492001869	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1229492001870	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1229492001871	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229492001872	active site
1229492001873	DNA binding site [nucleotide binding]
1229492001874	Int/Topo IB signature motif; other site
1229492001875	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
1229492001876	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229492001877	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1229492001878	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
1229492001879	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
1229492001880	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1229492001881	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229492001882	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1229492001883	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
1229492001884	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1229492001885	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1229492001886	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229492001887	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1229492001888	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1229492001889	metal binding site [ion binding]; metal-binding site
1229492001890	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1229492001891	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492001892	ABC-ATPase subunit  interface; other site
1229492001893	dimer interface [polypeptide binding]; other site
1229492001894	putative PBP binding regions; other site
1229492001895	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1229492001896	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1229492001897	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1229492001898	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1229492001899	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1229492001900	FeoA domain; Region: FeoA; pfam04023
1229492001901	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1229492001902	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1229492001903	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1229492001904	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
1229492001905	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1229492001906	Walker A/P-loop; other site
1229492001907	ATP binding site [chemical binding]; other site
1229492001908	Q-loop/lid; other site
1229492001909	ABC transporter signature motif; other site
1229492001910	Walker B; other site
1229492001911	D-loop; other site
1229492001912	H-loop/switch region; other site
1229492001913	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1229492001914	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229492001915	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229492001916	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229492001917	active site
1229492001918	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229492001919	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1229492001920	active site
1229492001921	nucleotide binding site [chemical binding]; other site
1229492001922	HIGH motif; other site
1229492001923	KMSKS motif; other site
1229492001924	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1229492001925	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1229492001926	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1229492001927	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229492001928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229492001929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492001930	Walker A/P-loop; other site
1229492001931	ATP binding site [chemical binding]; other site
1229492001932	Q-loop/lid; other site
1229492001933	ABC transporter signature motif; other site
1229492001934	Walker B; other site
1229492001935	D-loop; other site
1229492001936	H-loop/switch region; other site
1229492001937	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1229492001938	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1229492001939	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1229492001940	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1229492001941	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1229492001942	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1229492001943	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1229492001944	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1229492001945	Walker A/P-loop; other site
1229492001946	ATP binding site [chemical binding]; other site
1229492001947	Q-loop/lid; other site
1229492001948	ABC transporter signature motif; other site
1229492001949	Walker B; other site
1229492001950	D-loop; other site
1229492001951	H-loop/switch region; other site
1229492001952	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229492001953	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492001954	ABC-ATPase subunit  interface; other site
1229492001955	dimer interface [polypeptide binding]; other site
1229492001956	putative PBP binding regions; other site
1229492001957	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1229492001958	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492001959	ABC-ATPase subunit  interface; other site
1229492001960	dimer interface [polypeptide binding]; other site
1229492001961	putative PBP binding regions; other site
1229492001962	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1229492001963	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1229492001964	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1229492001965	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1229492001966	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1229492001967	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1229492001968	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1229492001969	Na binding site [ion binding]; other site
1229492001970	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1229492001971	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1229492001972	substrate binding pocket [chemical binding]; other site
1229492001973	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229492001974	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229492001975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492001976	Coenzyme A binding pocket [chemical binding]; other site
1229492001977	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229492001978	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229492001979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492001980	NAD(P) binding site [chemical binding]; other site
1229492001981	active site
1229492001982	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492001983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492001984	active site
1229492001985	phosphorylation site [posttranslational modification]
1229492001986	intermolecular recognition site; other site
1229492001987	dimerization interface [polypeptide binding]; other site
1229492001988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492001989	DNA binding site [nucleotide binding]
1229492001990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229492001991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1229492001992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492001993	ATP binding site [chemical binding]; other site
1229492001994	Mg2+ binding site [ion binding]; other site
1229492001995	G-X-G motif; other site
1229492001996	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229492001997	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229492001998	Walker A/P-loop; other site
1229492001999	ATP binding site [chemical binding]; other site
1229492002000	Q-loop/lid; other site
1229492002001	ABC transporter signature motif; other site
1229492002002	Walker B; other site
1229492002003	D-loop; other site
1229492002004	H-loop/switch region; other site
1229492002005	FtsX-like permease family; Region: FtsX; pfam02687
1229492002006	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1229492002007	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1229492002008	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492002009	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1229492002010	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492002011	Surface antigen [General function prediction only]; Region: COG3942
1229492002012	CHAP domain; Region: CHAP; pfam05257
1229492002013	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1229492002014	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1229492002015	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229492002016	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492002017	hypothetical protein; Provisional; Region: PRK12378
1229492002018	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1229492002019	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1229492002020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229492002021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229492002022	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229492002023	dimerization interface [polypeptide binding]; other site
1229492002024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492002025	sugar efflux transporter; Region: 2A0120; TIGR00899
1229492002026	putative substrate translocation pore; other site
1229492002027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1229492002028	Serine incorporator (Serinc); Region: Serinc; pfam03348
1229492002029	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229492002030	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492002031	Coenzyme A binding pocket [chemical binding]; other site
1229492002032	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229492002033	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229492002034	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
1229492002035	hypothetical protein; Validated; Region: PRK00124
1229492002036	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1229492002037	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1229492002038	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1229492002039	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229492002040	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1229492002041	Walker A/P-loop; other site
1229492002042	ATP binding site [chemical binding]; other site
1229492002043	Q-loop/lid; other site
1229492002044	ABC transporter signature motif; other site
1229492002045	Walker B; other site
1229492002046	D-loop; other site
1229492002047	H-loop/switch region; other site
1229492002048	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1229492002049	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229492002050	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1229492002051	Walker A/P-loop; other site
1229492002052	ATP binding site [chemical binding]; other site
1229492002053	Q-loop/lid; other site
1229492002054	ABC transporter signature motif; other site
1229492002055	Walker B; other site
1229492002056	D-loop; other site
1229492002057	H-loop/switch region; other site
1229492002058	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229492002059	MarR family; Region: MarR; pfam01047
1229492002060	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1229492002061	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1229492002062	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1229492002063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229492002064	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229492002065	active site
1229492002066	catalytic tetrad [active]
1229492002067	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1229492002068	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1229492002069	transmembrane helices; other site
1229492002070	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1229492002071	DNA photolyase; Region: DNA_photolyase; pfam00875
1229492002072	Predicted membrane protein [Function unknown]; Region: COG4330
1229492002073	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1229492002074	trimer interface [polypeptide binding]; other site
1229492002075	putative Zn binding site [ion binding]; other site
1229492002076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492002077	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492002078	putative substrate translocation pore; other site
1229492002079	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1229492002080	putative deacylase active site [active]
1229492002081	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229492002082	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1229492002083	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229492002084	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1229492002085	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1229492002086	putative substrate binding site [chemical binding]; other site
1229492002087	putative ATP binding site [chemical binding]; other site
1229492002088	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1229492002089	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492002090	active site
1229492002091	phosphorylation site [posttranslational modification]
1229492002092	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1229492002093	active site
1229492002094	P-loop; other site
1229492002095	phosphorylation site [posttranslational modification]
1229492002096	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1229492002097	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1229492002098	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1229492002099	active site
1229492002100	dimer interface [polypeptide binding]; other site
1229492002101	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1229492002102	Domain of unknown function DUF21; Region: DUF21; pfam01595
1229492002103	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1229492002104	Transporter associated domain; Region: CorC_HlyC; pfam03471
1229492002105	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229492002106	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229492002107	active site
1229492002108	catalytic tetrad [active]
1229492002109	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1229492002110	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1229492002111	Ligand binding site; other site
1229492002112	Putative Catalytic site; other site
1229492002113	DXD motif; other site
1229492002114	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229492002115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492002116	dimer interface [polypeptide binding]; other site
1229492002117	phosphorylation site [posttranslational modification]
1229492002118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492002119	ATP binding site [chemical binding]; other site
1229492002120	Mg2+ binding site [ion binding]; other site
1229492002121	G-X-G motif; other site
1229492002122	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492002123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492002124	active site
1229492002125	phosphorylation site [posttranslational modification]
1229492002126	intermolecular recognition site; other site
1229492002127	dimerization interface [polypeptide binding]; other site
1229492002128	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492002129	DNA binding site [nucleotide binding]
1229492002130	DoxX; Region: DoxX; cl17842
1229492002131	Electron transfer DM13; Region: DM13; pfam10517
1229492002132	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1229492002133	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1229492002134	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1229492002135	active site
1229492002136	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1229492002137	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1229492002138	Ligand Binding Site [chemical binding]; other site
1229492002139	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1229492002140	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1229492002141	glutamine binding [chemical binding]; other site
1229492002142	catalytic triad [active]
1229492002143	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1229492002144	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1229492002145	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1229492002146	substrate-cofactor binding pocket; other site
1229492002147	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1229492002148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492002149	catalytic residue [active]
1229492002150	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1229492002151	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1229492002152	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1229492002153	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1229492002154	Sulfatase; Region: Sulfatase; pfam00884
1229492002155	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1229492002156	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492002157	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492002158	ABC transporter; Region: ABC_tran_2; pfam12848
1229492002159	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492002160	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1229492002161	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492002162	ATP binding site [chemical binding]; other site
1229492002163	putative Mg++ binding site [ion binding]; other site
1229492002164	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492002165	nucleotide binding region [chemical binding]; other site
1229492002166	ATP-binding site [chemical binding]; other site
1229492002167	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1229492002168	HRDC domain; Region: HRDC; pfam00570
1229492002169	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1229492002170	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1229492002171	Walker A/P-loop; other site
1229492002172	ATP binding site [chemical binding]; other site
1229492002173	Q-loop/lid; other site
1229492002174	ABC transporter signature motif; other site
1229492002175	Walker B; other site
1229492002176	D-loop; other site
1229492002177	H-loop/switch region; other site
1229492002178	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229492002179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492002180	dimer interface [polypeptide binding]; other site
1229492002181	conserved gate region; other site
1229492002182	ABC-ATPase subunit interface; other site
1229492002183	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1229492002184	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1229492002185	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1229492002186	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229492002187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492002188	homodimer interface [polypeptide binding]; other site
1229492002189	catalytic residue [active]
1229492002190	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1229492002191	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1229492002192	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1229492002193	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1229492002194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492002195	putative substrate translocation pore; other site
1229492002196	POT family; Region: PTR2; cl17359
1229492002197	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1229492002198	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229492002199	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
1229492002200	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1229492002201	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1229492002202	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1229492002203	active site
1229492002204	dimer interface [polypeptide binding]; other site
1229492002205	catalytic residues [active]
1229492002206	effector binding site; other site
1229492002207	R2 peptide binding site; other site
1229492002208	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1229492002209	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1229492002210	dimer interface [polypeptide binding]; other site
1229492002211	putative radical transfer pathway; other site
1229492002212	diiron center [ion binding]; other site
1229492002213	tyrosyl radical; other site
1229492002214	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492002215	ABC-ATPase subunit  interface; other site
1229492002216	dimer interface [polypeptide binding]; other site
1229492002217	putative PBP binding regions; other site
1229492002218	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492002219	ABC-ATPase subunit  interface; other site
1229492002220	dimer interface [polypeptide binding]; other site
1229492002221	putative PBP binding regions; other site
1229492002222	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1229492002223	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1229492002224	Walker A/P-loop; other site
1229492002225	ATP binding site [chemical binding]; other site
1229492002226	Q-loop/lid; other site
1229492002227	ABC transporter signature motif; other site
1229492002228	Walker B; other site
1229492002229	D-loop; other site
1229492002230	H-loop/switch region; other site
1229492002231	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1229492002232	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1229492002233	putative ligand binding residues [chemical binding]; other site
1229492002234	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1229492002235	CHY zinc finger; Region: zf-CHY; pfam05495
1229492002236	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1229492002237	FAD binding domain; Region: FAD_binding_4; pfam01565
1229492002238	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1229492002239	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1229492002240	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1229492002241	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1229492002242	peptidase T; Region: peptidase-T; TIGR01882
1229492002243	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1229492002244	metal binding site [ion binding]; metal-binding site
1229492002245	dimer interface [polypeptide binding]; other site
1229492002246	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1229492002247	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1229492002248	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1229492002249	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1229492002250	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1229492002251	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229492002252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229492002253	metal binding site [ion binding]; metal-binding site
1229492002254	active site
1229492002255	I-site; other site
1229492002256	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1229492002257	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1229492002258	Mg++ binding site [ion binding]; other site
1229492002259	putative catalytic motif [active]
1229492002260	substrate binding site [chemical binding]; other site
1229492002261	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1229492002262	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1229492002263	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1229492002264	EDD domain protein, DegV family; Region: DegV; TIGR00762
1229492002265	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1229492002266	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229492002267	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492002268	ATP binding site [chemical binding]; other site
1229492002269	putative Mg++ binding site [ion binding]; other site
1229492002270	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492002271	nucleotide binding region [chemical binding]; other site
1229492002272	ATP-binding site [chemical binding]; other site
1229492002273	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1229492002274	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492002275	active site
1229492002276	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1229492002277	30S subunit binding site; other site
1229492002278	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1229492002279	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1229492002280	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1229492002281	nucleotide binding region [chemical binding]; other site
1229492002282	ATP-binding site [chemical binding]; other site
1229492002283	SEC-C motif; Region: SEC-C; pfam02810
1229492002284	peptide chain release factor 2; Provisional; Region: PRK06746
1229492002285	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1229492002286	RF-1 domain; Region: RF-1; pfam00472
1229492002287	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1229492002288	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492002289	Surface antigen [General function prediction only]; Region: COG3942
1229492002290	CHAP domain; Region: CHAP; pfam05257
1229492002291	HD domain; Region: HD_3; cl17350
1229492002292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
1229492002293	excinuclease ABC subunit B; Provisional; Region: PRK05298
1229492002294	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492002295	ATP binding site [chemical binding]; other site
1229492002296	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492002297	nucleotide binding region [chemical binding]; other site
1229492002298	ATP-binding site [chemical binding]; other site
1229492002299	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1229492002300	UvrB/uvrC motif; Region: UVR; pfam02151
1229492002301	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1229492002302	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229492002303	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229492002304	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1229492002305	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1229492002306	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1229492002307	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1229492002308	Hpr binding site; other site
1229492002309	active site
1229492002310	homohexamer subunit interaction site [polypeptide binding]; other site
1229492002311	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1229492002312	putative acyl transferase; Provisional; Region: PRK10191
1229492002313	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1229492002314	trimer interface [polypeptide binding]; other site
1229492002315	active site
1229492002316	substrate binding site [chemical binding]; other site
1229492002317	CoA binding site [chemical binding]; other site
1229492002318	TPR repeat; Region: TPR_11; pfam13414
1229492002319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1229492002320	binding surface
1229492002321	TPR motif; other site
1229492002322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229492002323	TPR motif; other site
1229492002324	binding surface
1229492002325	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1229492002326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492002327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492002328	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1229492002329	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1229492002330	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1229492002331	phosphate binding site [ion binding]; other site
1229492002332	dimer interface [polypeptide binding]; other site
1229492002333	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1229492002334	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1229492002335	Clp protease; Region: CLP_protease; pfam00574
1229492002336	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1229492002337	oligomer interface [polypeptide binding]; other site
1229492002338	active site residues [active]
1229492002339	malate dehydrogenase; Provisional; Region: PRK13529
1229492002340	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1229492002341	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1229492002342	NAD(P) binding site [chemical binding]; other site
1229492002343	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1229492002344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492002345	NAD(P) binding site [chemical binding]; other site
1229492002346	active site
1229492002347	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1229492002348	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1229492002349	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1229492002350	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1229492002351	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1229492002352	Phosphoglycerate kinase; Region: PGK; pfam00162
1229492002353	substrate binding site [chemical binding]; other site
1229492002354	hinge regions; other site
1229492002355	ADP binding site [chemical binding]; other site
1229492002356	catalytic site [active]
1229492002357	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1229492002358	triosephosphate isomerase; Provisional; Region: PRK14565
1229492002359	substrate binding site [chemical binding]; other site
1229492002360	dimer interface [polypeptide binding]; other site
1229492002361	catalytic triad [active]
1229492002362	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1229492002363	phosphoglyceromutase; Provisional; Region: PRK05434
1229492002364	enolase; Provisional; Region: eno; PRK00077
1229492002365	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1229492002366	dimer interface [polypeptide binding]; other site
1229492002367	metal binding site [ion binding]; metal-binding site
1229492002368	substrate binding pocket [chemical binding]; other site
1229492002369	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1229492002370	Esterase/lipase [General function prediction only]; Region: COG1647
1229492002371	ribonuclease R; Region: RNase_R; TIGR02063
1229492002372	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1229492002373	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1229492002374	RNB domain; Region: RNB; pfam00773
1229492002375	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1229492002376	RNA binding site [nucleotide binding]; other site
1229492002377	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1229492002378	SmpB-tmRNA interface; other site
1229492002379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492002380	Coenzyme A binding pocket [chemical binding]; other site
1229492002381	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492002382	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492002383	Staphylococcal nuclease homologues; Region: SNc; smart00318
1229492002384	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1229492002385	Catalytic site; other site
1229492002386	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229492002387	DNA-binding site [nucleotide binding]; DNA binding site
1229492002388	RNA-binding motif; other site
1229492002389	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1229492002390	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1229492002391	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229492002392	catalytic core [active]
1229492002393	Lysine efflux permease [General function prediction only]; Region: COG1279
1229492002394	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1229492002395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229492002396	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1229492002397	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1229492002398	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1229492002399	active site
1229492002400	catalytic residue [active]
1229492002401	dimer interface [polypeptide binding]; other site
1229492002402	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1229492002403	FMN binding site [chemical binding]; other site
1229492002404	dimer interface [polypeptide binding]; other site
1229492002405	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229492002406	catalytic residues [active]
1229492002407	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1229492002408	ArsC family; Region: ArsC; pfam03960
1229492002409	putative ArsC-like catalytic residues; other site
1229492002410	putative TRX-like catalytic residues [active]
1229492002411	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1229492002412	lipoyl attachment site [posttranslational modification]; other site
1229492002413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1229492002414	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1229492002415	putative active site [active]
1229492002416	putative metal binding site [ion binding]; other site
1229492002417	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229492002418	catalytic residues [active]
1229492002419	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1229492002420	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1229492002421	Walker A/P-loop; other site
1229492002422	ATP binding site [chemical binding]; other site
1229492002423	Q-loop/lid; other site
1229492002424	ABC transporter signature motif; other site
1229492002425	Walker B; other site
1229492002426	D-loop; other site
1229492002427	H-loop/switch region; other site
1229492002428	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1229492002429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492002430	dimer interface [polypeptide binding]; other site
1229492002431	conserved gate region; other site
1229492002432	ABC-ATPase subunit interface; other site
1229492002433	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1229492002434	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229492002435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1229492002436	Predicted membrane protein [Function unknown]; Region: COG2035
1229492002437	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1229492002438	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1229492002439	Walker A/P-loop; other site
1229492002440	ATP binding site [chemical binding]; other site
1229492002441	Q-loop/lid; other site
1229492002442	ABC transporter signature motif; other site
1229492002443	Walker B; other site
1229492002444	D-loop; other site
1229492002445	H-loop/switch region; other site
1229492002446	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1229492002447	FeS assembly protein SufD; Region: sufD; TIGR01981
1229492002448	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1229492002449	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1229492002450	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492002451	catalytic residue [active]
1229492002452	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1229492002453	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1229492002454	trimerization site [polypeptide binding]; other site
1229492002455	active site
1229492002456	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1229492002457	FeS assembly protein SufB; Region: sufB; TIGR01980
1229492002458	Domain of unknown function DUF21; Region: DUF21; pfam01595
1229492002459	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1229492002460	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1229492002461	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1229492002462	FMN binding site [chemical binding]; other site
1229492002463	substrate binding site [chemical binding]; other site
1229492002464	putative catalytic residue [active]
1229492002465	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1229492002466	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1229492002467	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1229492002468	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1229492002469	active site
1229492002470	metal binding site [ion binding]; metal-binding site
1229492002471	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229492002472	lipoyl synthase; Provisional; Region: PRK05481
1229492002473	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492002474	FeS/SAM binding site; other site
1229492002475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
1229492002476	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1229492002477	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1229492002478	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1229492002479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492002480	active site
1229492002481	motif I; other site
1229492002482	motif II; other site
1229492002483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492002484	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1229492002485	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1229492002486	dimerization interface [polypeptide binding]; other site
1229492002487	ligand binding site [chemical binding]; other site
1229492002488	NADP binding site [chemical binding]; other site
1229492002489	catalytic site [active]
1229492002490	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1229492002491	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1229492002492	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1229492002493	acyl-activating enzyme (AAE) consensus motif; other site
1229492002494	AMP binding site [chemical binding]; other site
1229492002495	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1229492002496	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1229492002497	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1229492002498	DltD N-terminal region; Region: DltD_N; pfam04915
1229492002499	DltD central region; Region: DltD_M; pfam04918
1229492002500	DltD C-terminal region; Region: DltD_C; pfam04914
1229492002501	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1229492002502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
1229492002503	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1229492002504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492002505	hypothetical protein; Provisional; Region: PRK13669
1229492002506	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1229492002507	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1229492002508	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492002509	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1229492002510	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1229492002511	interface (dimer of trimers) [polypeptide binding]; other site
1229492002512	Substrate-binding/catalytic site; other site
1229492002513	Zn-binding sites [ion binding]; other site
1229492002514	Predicted permease [General function prediction only]; Region: COG2056
1229492002515	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1229492002516	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1229492002517	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229492002518	CoenzymeA binding site [chemical binding]; other site
1229492002519	subunit interaction site [polypeptide binding]; other site
1229492002520	PHB binding site; other site
1229492002521	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492002522	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1229492002523	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
1229492002524	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
1229492002525	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
1229492002526	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1229492002527	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229492002528	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
1229492002529	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1229492002530	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1229492002531	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229492002532	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1229492002533	Kinase associated protein B; Region: KapB; pfam08810
1229492002534	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1229492002535	active site
1229492002536	general stress protein 13; Validated; Region: PRK08059
1229492002537	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1229492002538	RNA binding site [nucleotide binding]; other site
1229492002539	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1229492002540	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1229492002541	putative active site [active]
1229492002542	putative FMN binding site [chemical binding]; other site
1229492002543	putative substrate binding site [chemical binding]; other site
1229492002544	putative catalytic residue [active]
1229492002545	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1229492002546	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229492002547	inhibitor-cofactor binding pocket; inhibition site
1229492002548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492002549	catalytic residue [active]
1229492002550	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1229492002551	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1229492002552	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1229492002553	NAD(P) binding site [chemical binding]; other site
1229492002554	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229492002555	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1229492002556	active site
1229492002557	catalytic site [active]
1229492002558	metal binding site [ion binding]; metal-binding site
1229492002559	argininosuccinate lyase; Provisional; Region: PRK00855
1229492002560	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1229492002561	active sites [active]
1229492002562	tetramer interface [polypeptide binding]; other site
1229492002563	argininosuccinate synthase; Provisional; Region: PRK13820
1229492002564	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1229492002565	ANP binding site [chemical binding]; other site
1229492002566	Substrate Binding Site II [chemical binding]; other site
1229492002567	Substrate Binding Site I [chemical binding]; other site
1229492002568	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1229492002569	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1229492002570	active site
1229492002571	dimer interface [polypeptide binding]; other site
1229492002572	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1229492002573	dimer interface [polypeptide binding]; other site
1229492002574	active site
1229492002575	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1229492002576	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1229492002577	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229492002578	Catalytic site [active]
1229492002579	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1229492002580	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229492002581	Catalytic site [active]
1229492002582	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1229492002583	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1229492002584	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1229492002585	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1229492002586	Part of AAA domain; Region: AAA_19; pfam13245
1229492002587	Family description; Region: UvrD_C_2; pfam13538
1229492002588	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1229492002589	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229492002590	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229492002591	hypothetical protein; Provisional; Region: PRK13673
1229492002592	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
1229492002593	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1229492002594	Int/Topo IB signature motif; other site
1229492002595	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
1229492002596	Helix-turn-helix domain; Region: HTH_16; pfam12645
1229492002597	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1229492002598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229492002599	DNA binding residues [nucleotide binding]
1229492002600	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492002601	non-specific DNA binding site [nucleotide binding]; other site
1229492002602	salt bridge; other site
1229492002603	sequence-specific DNA binding site [nucleotide binding]; other site
1229492002604	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1229492002605	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1229492002606	G1 box; other site
1229492002607	putative GEF interaction site [polypeptide binding]; other site
1229492002608	GTP/Mg2+ binding site [chemical binding]; other site
1229492002609	Switch I region; other site
1229492002610	G2 box; other site
1229492002611	G3 box; other site
1229492002612	Switch II region; other site
1229492002613	G4 box; other site
1229492002614	G5 box; other site
1229492002615	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
1229492002616	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
1229492002617	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1229492002618	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1229492002619	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229492002620	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229492002621	catalytic residue [active]
1229492002622	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1229492002623	NlpC/P60 family; Region: NLPC_P60; pfam00877
1229492002624	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1229492002625	Haemolysin-III related; Region: HlyIII; cl03831
1229492002626	AAA-like domain; Region: AAA_10; pfam12846
1229492002627	TcpE family; Region: TcpE; pfam12648
1229492002628	Antirestriction protein (ArdA); Region: ArdA; pfam07275
1229492002629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492002630	non-specific DNA binding site [nucleotide binding]; other site
1229492002631	salt bridge; other site
1229492002632	sequence-specific DNA binding site [nucleotide binding]; other site
1229492002633	Replication initiation factor; Region: Rep_trans; pfam02486
1229492002634	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1229492002635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492002636	Walker A motif; other site
1229492002637	ATP binding site [chemical binding]; other site
1229492002638	Walker B motif; other site
1229492002639	arginine finger; other site
1229492002640	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1229492002641	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1229492002642	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229492002643	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229492002644	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229492002645	coenzyme A disulfide reductase; Provisional; Region: PRK13512
1229492002646	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492002647	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492002648	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229492002649	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1229492002650	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492002651	active site
1229492002652	motif I; other site
1229492002653	motif II; other site
1229492002654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492002655	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1229492002656	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229492002657	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1229492002658	catalytic triad [active]
1229492002659	catalytic triad [active]
1229492002660	oxyanion hole [active]
1229492002661	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1229492002662	Clp amino terminal domain; Region: Clp_N; pfam02861
1229492002663	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492002664	Walker A motif; other site
1229492002665	ATP binding site [chemical binding]; other site
1229492002666	Walker B motif; other site
1229492002667	arginine finger; other site
1229492002668	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1229492002669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492002670	Walker A motif; other site
1229492002671	ATP binding site [chemical binding]; other site
1229492002672	Walker B motif; other site
1229492002673	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1229492002674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229492002675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229492002676	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229492002677	dimerization interface [polypeptide binding]; other site
1229492002678	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1229492002679	substrate binding site [chemical binding]; other site
1229492002680	MAP domain; Region: MAP; pfam03642
1229492002681	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1229492002682	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1229492002683	dimer interface [polypeptide binding]; other site
1229492002684	active site
1229492002685	CoA binding pocket [chemical binding]; other site
1229492002686	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1229492002687	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1229492002688	dimer interface [polypeptide binding]; other site
1229492002689	active site
1229492002690	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1229492002691	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229492002692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492002693	dimer interface [polypeptide binding]; other site
1229492002694	conserved gate region; other site
1229492002695	putative PBP binding loops; other site
1229492002696	ABC-ATPase subunit interface; other site
1229492002697	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1229492002698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492002699	dimer interface [polypeptide binding]; other site
1229492002700	conserved gate region; other site
1229492002701	putative PBP binding loops; other site
1229492002702	ABC-ATPase subunit interface; other site
1229492002703	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1229492002704	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492002705	Walker A/P-loop; other site
1229492002706	ATP binding site [chemical binding]; other site
1229492002707	Q-loop/lid; other site
1229492002708	ABC transporter signature motif; other site
1229492002709	Walker B; other site
1229492002710	D-loop; other site
1229492002711	H-loop/switch region; other site
1229492002712	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229492002713	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229492002714	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492002715	Walker A/P-loop; other site
1229492002716	ATP binding site [chemical binding]; other site
1229492002717	Q-loop/lid; other site
1229492002718	ABC transporter signature motif; other site
1229492002719	Walker B; other site
1229492002720	D-loop; other site
1229492002721	H-loop/switch region; other site
1229492002722	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229492002723	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1229492002724	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1229492002725	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1229492002726	peptide binding site [polypeptide binding]; other site
1229492002727	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229492002728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492002729	ABC-ATPase subunit interface; other site
1229492002730	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1229492002731	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1229492002732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492002733	dimer interface [polypeptide binding]; other site
1229492002734	conserved gate region; other site
1229492002735	putative PBP binding loops; other site
1229492002736	ABC-ATPase subunit interface; other site
1229492002737	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1229492002738	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492002739	Walker A/P-loop; other site
1229492002740	ATP binding site [chemical binding]; other site
1229492002741	Q-loop/lid; other site
1229492002742	ABC transporter signature motif; other site
1229492002743	Walker B; other site
1229492002744	D-loop; other site
1229492002745	H-loop/switch region; other site
1229492002746	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229492002747	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229492002748	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492002749	Walker A/P-loop; other site
1229492002750	ATP binding site [chemical binding]; other site
1229492002751	Q-loop/lid; other site
1229492002752	ABC transporter signature motif; other site
1229492002753	Walker B; other site
1229492002754	D-loop; other site
1229492002755	H-loop/switch region; other site
1229492002756	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229492002757	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1229492002758	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1229492002759	peptide binding site [polypeptide binding]; other site
1229492002760	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1229492002761	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1229492002762	active site
1229492002763	HIGH motif; other site
1229492002764	dimer interface [polypeptide binding]; other site
1229492002765	KMSKS motif; other site
1229492002766	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1229492002767	ArsC family; Region: ArsC; pfam03960
1229492002768	putative catalytic residues [active]
1229492002769	thiol/disulfide switch; other site
1229492002770	adaptor protein; Provisional; Region: PRK02315
1229492002771	Competence protein CoiA-like family; Region: CoiA; cl11541
1229492002772	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1229492002773	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1229492002774	active site
1229492002775	Zn binding site [ion binding]; other site
1229492002776	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1229492002777	Thioredoxin; Region: Thioredoxin_5; pfam13743
1229492002778	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1229492002779	apolar tunnel; other site
1229492002780	heme binding site [chemical binding]; other site
1229492002781	dimerization interface [polypeptide binding]; other site
1229492002782	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1229492002783	putative active site [active]
1229492002784	putative metal binding residues [ion binding]; other site
1229492002785	signature motif; other site
1229492002786	putative triphosphate binding site [ion binding]; other site
1229492002787	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229492002788	synthetase active site [active]
1229492002789	NTP binding site [chemical binding]; other site
1229492002790	metal binding site [ion binding]; metal-binding site
1229492002791	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1229492002792	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1229492002793	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229492002794	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229492002795	active site
1229492002796	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1229492002797	MgtE intracellular N domain; Region: MgtE_N; smart00924
1229492002798	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1229492002799	Divalent cation transporter; Region: MgtE; pfam01769
1229492002800	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1229492002801	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229492002802	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1229492002803	TrkA-N domain; Region: TrkA_N; pfam02254
1229492002804	TrkA-C domain; Region: TrkA_C; pfam02080
1229492002805	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1229492002806	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1229492002807	NAD binding site [chemical binding]; other site
1229492002808	homotetramer interface [polypeptide binding]; other site
1229492002809	homodimer interface [polypeptide binding]; other site
1229492002810	substrate binding site [chemical binding]; other site
1229492002811	active site
1229492002812	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229492002813	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229492002814	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1229492002815	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1229492002816	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1229492002817	Putative esterase; Region: Esterase; pfam00756
1229492002818	hypothetical protein; Provisional; Region: PRK13679
1229492002819	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1229492002820	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492002821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492002822	putative substrate translocation pore; other site
1229492002823	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1229492002824	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1229492002825	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229492002826	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1229492002827	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229492002828	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229492002829	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229492002830	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1229492002831	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1229492002832	G1 box; other site
1229492002833	putative GEF interaction site [polypeptide binding]; other site
1229492002834	GTP/Mg2+ binding site [chemical binding]; other site
1229492002835	Switch I region; other site
1229492002836	G2 box; other site
1229492002837	G3 box; other site
1229492002838	Switch II region; other site
1229492002839	G4 box; other site
1229492002840	G5 box; other site
1229492002841	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1229492002842	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1229492002843	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1229492002844	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229492002845	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229492002846	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1229492002847	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1229492002848	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1229492002849	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1229492002850	active site
1229492002851	metal binding site [ion binding]; metal-binding site
1229492002852	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229492002853	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1229492002854	IDEAL domain; Region: IDEAL; pfam08858
1229492002855	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1229492002856	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1229492002857	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1229492002858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
1229492002859	CAAX protease self-immunity; Region: Abi; pfam02517
1229492002860	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
1229492002861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1229492002862	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1229492002863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1229492002864	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229492002865	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1229492002866	Walker A/P-loop; other site
1229492002867	ATP binding site [chemical binding]; other site
1229492002868	Q-loop/lid; other site
1229492002869	ABC transporter signature motif; other site
1229492002870	Walker B; other site
1229492002871	D-loop; other site
1229492002872	H-loop/switch region; other site
1229492002873	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229492002874	Predicted membrane protein [Function unknown]; Region: COG2259
1229492002875	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1229492002876	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1229492002877	siderophore binding site; other site
1229492002878	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1229492002879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492002880	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229492002881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229492002882	Coenzyme A binding pocket [chemical binding]; other site
1229492002883	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1229492002884	UbiA prenyltransferase family; Region: UbiA; pfam01040
1229492002885	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1229492002886	isochorismate synthases; Region: isochor_syn; TIGR00543
1229492002887	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1229492002888	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1229492002889	dimer interface [polypeptide binding]; other site
1229492002890	tetramer interface [polypeptide binding]; other site
1229492002891	PYR/PP interface [polypeptide binding]; other site
1229492002892	TPP binding site [chemical binding]; other site
1229492002893	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1229492002894	TPP-binding site; other site
1229492002895	Mysoin-binding motif of peroxisomes; Region: Vezatin; pfam12632
1229492002896	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1229492002897	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229492002898	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1229492002899	substrate binding site [chemical binding]; other site
1229492002900	oxyanion hole (OAH) forming residues; other site
1229492002901	trimer interface [polypeptide binding]; other site
1229492002902	Staphostatin B; Region: Staphostatin_B; pfam09023
1229492002903	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1229492002904	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1229492002905	aminotransferase A; Validated; Region: PRK07683
1229492002906	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229492002907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492002908	homodimer interface [polypeptide binding]; other site
1229492002909	catalytic residue [active]
1229492002910	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1229492002911	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1229492002912	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492002913	MarR family; Region: MarR; pfam01047
1229492002914	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1229492002915	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1229492002916	amidase catalytic site [active]
1229492002917	Zn binding residues [ion binding]; other site
1229492002918	substrate binding site [chemical binding]; other site
1229492002919	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1229492002920	Lysozyme subfamily 2; Region: LYZ2; smart00047
1229492002921	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1229492002922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492002923	Coenzyme A binding pocket [chemical binding]; other site
1229492002924	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1229492002925	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1229492002926	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229492002927	Beta-lactamase; Region: Beta-lactamase; pfam00144
1229492002928	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
1229492002929	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1229492002930	Subunit I/III interface [polypeptide binding]; other site
1229492002931	Subunit III/IV interface [polypeptide binding]; other site
1229492002932	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1229492002933	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1229492002934	D-pathway; other site
1229492002935	Putative ubiquinol binding site [chemical binding]; other site
1229492002936	Low-spin heme (heme b) binding site [chemical binding]; other site
1229492002937	Putative water exit pathway; other site
1229492002938	Binuclear center (heme o3/CuB) [ion binding]; other site
1229492002939	K-pathway; other site
1229492002940	Putative proton exit pathway; other site
1229492002941	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1229492002942	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1229492002943	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1229492002944	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1229492002945	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
1229492002946	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1229492002947	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1229492002948	homodimer interface [polypeptide binding]; other site
1229492002949	NADP binding site [chemical binding]; other site
1229492002950	substrate binding site [chemical binding]; other site
1229492002951	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1229492002952	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1229492002953	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229492002954	NAD binding site [chemical binding]; other site
1229492002955	ATP-grasp domain; Region: ATP-grasp; pfam02222
1229492002956	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1229492002957	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1229492002958	ATP binding site [chemical binding]; other site
1229492002959	active site
1229492002960	substrate binding site [chemical binding]; other site
1229492002961	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
1229492002962	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1229492002963	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1229492002964	putative active site [active]
1229492002965	catalytic triad [active]
1229492002966	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1229492002967	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1229492002968	dimerization interface [polypeptide binding]; other site
1229492002969	ATP binding site [chemical binding]; other site
1229492002970	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1229492002971	dimerization interface [polypeptide binding]; other site
1229492002972	ATP binding site [chemical binding]; other site
1229492002973	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1229492002974	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1229492002975	active site
1229492002976	tetramer interface [polypeptide binding]; other site
1229492002977	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492002978	active site
1229492002979	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1229492002980	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1229492002981	dimerization interface [polypeptide binding]; other site
1229492002982	putative ATP binding site [chemical binding]; other site
1229492002983	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1229492002984	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1229492002985	active site
1229492002986	substrate binding site [chemical binding]; other site
1229492002987	cosubstrate binding site; other site
1229492002988	catalytic site [active]
1229492002989	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1229492002990	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1229492002991	purine monophosphate binding site [chemical binding]; other site
1229492002992	dimer interface [polypeptide binding]; other site
1229492002993	putative catalytic residues [active]
1229492002994	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1229492002995	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1229492002996	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1229492002997	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
1229492002998	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1229492002999	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1229492003000	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1229492003001	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1229492003002	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229492003003	Walker A/P-loop; other site
1229492003004	ATP binding site [chemical binding]; other site
1229492003005	Q-loop/lid; other site
1229492003006	ABC transporter signature motif; other site
1229492003007	Walker B; other site
1229492003008	D-loop; other site
1229492003009	H-loop/switch region; other site
1229492003010	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1229492003011	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229492003012	Walker A/P-loop; other site
1229492003013	ATP binding site [chemical binding]; other site
1229492003014	Q-loop/lid; other site
1229492003015	ABC transporter signature motif; other site
1229492003016	Walker B; other site
1229492003017	D-loop; other site
1229492003018	H-loop/switch region; other site
1229492003019	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1229492003020	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1229492003021	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1229492003022	putative RNA binding site [nucleotide binding]; other site
1229492003023	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1229492003024	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1229492003025	dimerization domain swap beta strand [polypeptide binding]; other site
1229492003026	regulatory protein interface [polypeptide binding]; other site
1229492003027	active site
1229492003028	regulatory phosphorylation site [posttranslational modification]; other site
1229492003029	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1229492003030	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1229492003031	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1229492003032	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1229492003033	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1229492003034	catalytic residues [active]
1229492003035	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1229492003036	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1229492003037	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1229492003038	TrkA-N domain; Region: TrkA_N; pfam02254
1229492003039	TrkA-C domain; Region: TrkA_C; pfam02080
1229492003040	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1229492003041	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1229492003042	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1229492003043	hypothetical protein; Provisional; Region: PRK13667
1229492003044	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1229492003045	active site
1229492003046	catalytic residues [active]
1229492003047	metal binding site [ion binding]; metal-binding site
1229492003048	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1229492003049	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1229492003050	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1229492003051	TPP-binding site [chemical binding]; other site
1229492003052	tetramer interface [polypeptide binding]; other site
1229492003053	heterodimer interface [polypeptide binding]; other site
1229492003054	phosphorylation loop region [posttranslational modification]
1229492003055	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1229492003056	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1229492003057	alpha subunit interface [polypeptide binding]; other site
1229492003058	TPP binding site [chemical binding]; other site
1229492003059	heterodimer interface [polypeptide binding]; other site
1229492003060	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229492003061	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1229492003062	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229492003063	E3 interaction surface; other site
1229492003064	lipoyl attachment site [posttranslational modification]; other site
1229492003065	e3 binding domain; Region: E3_binding; pfam02817
1229492003066	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1229492003067	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1229492003068	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229492003069	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492003070	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229492003071	hypothetical protein; Provisional; Region: PRK04387
1229492003072	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229492003073	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492003074	non-specific DNA binding site [nucleotide binding]; other site
1229492003075	salt bridge; other site
1229492003076	sequence-specific DNA binding site [nucleotide binding]; other site
1229492003077	Cupin domain; Region: Cupin_2; pfam07883
1229492003078	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229492003079	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492003080	Walker A/P-loop; other site
1229492003081	ATP binding site [chemical binding]; other site
1229492003082	Q-loop/lid; other site
1229492003083	ABC transporter signature motif; other site
1229492003084	Walker B; other site
1229492003085	D-loop; other site
1229492003086	H-loop/switch region; other site
1229492003087	TOBE domain; Region: TOBE_2; pfam08402
1229492003088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492003089	putative PBP binding loops; other site
1229492003090	dimer interface [polypeptide binding]; other site
1229492003091	ABC-ATPase subunit interface; other site
1229492003092	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229492003093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492003094	dimer interface [polypeptide binding]; other site
1229492003095	conserved gate region; other site
1229492003096	putative PBP binding loops; other site
1229492003097	ABC-ATPase subunit interface; other site
1229492003098	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229492003099	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
1229492003100	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229492003101	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1229492003102	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1229492003103	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1229492003104	manganese transport protein MntH; Reviewed; Region: PRK00701
1229492003105	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229492003106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1229492003107	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1229492003108	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1229492003109	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1229492003110	active site
1229492003111	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1229492003112	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1229492003113	G1 box; other site
1229492003114	putative GEF interaction site [polypeptide binding]; other site
1229492003115	GTP/Mg2+ binding site [chemical binding]; other site
1229492003116	Switch I region; other site
1229492003117	G2 box; other site
1229492003118	G3 box; other site
1229492003119	Switch II region; other site
1229492003120	G4 box; other site
1229492003121	G5 box; other site
1229492003122	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1229492003123	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1229492003124	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
1229492003125	hypothetical protein; Provisional; Region: PRK13666
1229492003126	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1229492003127	pyruvate carboxylase; Reviewed; Region: PRK12999
1229492003128	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229492003129	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1229492003130	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1229492003131	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1229492003132	active site
1229492003133	catalytic residues [active]
1229492003134	metal binding site [ion binding]; metal-binding site
1229492003135	homodimer binding site [polypeptide binding]; other site
1229492003136	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229492003137	carboxyltransferase (CT) interaction site; other site
1229492003138	biotinylation site [posttranslational modification]; other site
1229492003139	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1229492003140	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1229492003141	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1229492003142	UbiA prenyltransferase family; Region: UbiA; pfam01040
1229492003143	Predicted membrane protein [Function unknown]; Region: COG2322
1229492003144	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1229492003145	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1229492003146	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
1229492003147	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229492003148	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1229492003149	putative active site [active]
1229492003150	catalytic site [active]
1229492003151	putative metal binding site [ion binding]; other site
1229492003152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
1229492003153	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1229492003154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492003155	S-adenosylmethionine binding site [chemical binding]; other site
1229492003156	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1229492003157	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1229492003158	active site
1229492003159	(T/H)XGH motif; other site
1229492003160	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1229492003161	hypothetical protein; Provisional; Region: PRK13670
1229492003162	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1229492003163	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1229492003164	heme uptake protein IsdB; Region: IsdB; TIGR03657
1229492003165	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492003166	NEAr Transporter domain; Region: NEAT; smart00725
1229492003167	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1229492003168	heme-binding site [chemical binding]; other site
1229492003169	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1229492003170	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
1229492003171	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1229492003172	heme-binding site [chemical binding]; other site
1229492003173	heme uptake protein IsdC; Region: IsdC; TIGR03656
1229492003174	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1229492003175	heme-binding site [chemical binding]; other site
1229492003176	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
1229492003177	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1229492003178	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1229492003179	intersubunit interface [polypeptide binding]; other site
1229492003180	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229492003181	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492003182	ABC-ATPase subunit  interface; other site
1229492003183	dimer interface [polypeptide binding]; other site
1229492003184	putative PBP binding regions; other site
1229492003185	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1229492003186	active site
1229492003187	catalytic site [active]
1229492003188	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
1229492003189	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1229492003190	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1229492003191	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1229492003192	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1229492003193	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1229492003194	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1229492003195	dimer interface [polypeptide binding]; other site
1229492003196	motif 1; other site
1229492003197	active site
1229492003198	motif 2; other site
1229492003199	motif 3; other site
1229492003200	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1229492003201	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1229492003202	putative tRNA-binding site [nucleotide binding]; other site
1229492003203	B3/4 domain; Region: B3_4; pfam03483
1229492003204	tRNA synthetase B5 domain; Region: B5; smart00874
1229492003205	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1229492003206	dimer interface [polypeptide binding]; other site
1229492003207	motif 1; other site
1229492003208	motif 3; other site
1229492003209	motif 2; other site
1229492003210	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1229492003211	ribonuclease HIII; Provisional; Region: PRK00996
1229492003212	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1229492003213	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1229492003214	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229492003215	active site
1229492003216	Cell division protein ZapA; Region: ZapA; cl01146
1229492003217	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1229492003218	Colicin V production protein; Region: Colicin_V; pfam02674
1229492003219	hypothetical protein; Provisional; Region: PRK08609
1229492003220	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1229492003221	active site
1229492003222	primer binding site [nucleotide binding]; other site
1229492003223	NTP  binding site [chemical binding]; other site
1229492003224	metal binding triad [ion binding]; metal-binding site
1229492003225	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1229492003226	active site
1229492003227	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1229492003228	MutS domain III; Region: MutS_III; pfam05192
1229492003229	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1229492003230	Walker A/P-loop; other site
1229492003231	ATP binding site [chemical binding]; other site
1229492003232	Q-loop/lid; other site
1229492003233	ABC transporter signature motif; other site
1229492003234	Walker B; other site
1229492003235	D-loop; other site
1229492003236	H-loop/switch region; other site
1229492003237	Smr domain; Region: Smr; pfam01713
1229492003238	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229492003239	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229492003240	catalytic residues [active]
1229492003241	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1229492003242	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1229492003243	GIY-YIG motif/motif A; other site
1229492003244	active site
1229492003245	catalytic site [active]
1229492003246	putative DNA binding site [nucleotide binding]; other site
1229492003247	metal binding site [ion binding]; metal-binding site
1229492003248	UvrB/uvrC motif; Region: UVR; pfam02151
1229492003249	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1229492003250	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1229492003251	putative Iron-sulfur protein interface [polypeptide binding]; other site
1229492003252	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1229492003253	proximal heme binding site [chemical binding]; other site
1229492003254	distal heme binding site [chemical binding]; other site
1229492003255	putative dimer interface [polypeptide binding]; other site
1229492003256	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1229492003257	L-aspartate oxidase; Provisional; Region: PRK06175
1229492003258	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1229492003259	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1229492003260	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1229492003261	glutamate racemase; Provisional; Region: PRK00865
1229492003262	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1229492003263	active site
1229492003264	dimerization interface [polypeptide binding]; other site
1229492003265	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1229492003266	active site
1229492003267	metal binding site [ion binding]; metal-binding site
1229492003268	homotetramer interface [polypeptide binding]; other site
1229492003269	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1229492003270	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
1229492003271	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1229492003272	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1229492003273	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1229492003274	superantigen-like protein; Reviewed; Region: PRK13350
1229492003275	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492003276	superantigen-like protein; Reviewed; Region: PRK13349
1229492003277	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492003278	superantigen-like protein; Reviewed; Region: PRK13043
1229492003279	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492003280	ornithine carbamoyltransferase; Provisional; Region: PRK04284
1229492003281	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229492003282	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229492003283	carbamate kinase; Reviewed; Region: PRK12686
1229492003284	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1229492003285	putative substrate binding site [chemical binding]; other site
1229492003286	nucleotide binding site [chemical binding]; other site
1229492003287	nucleotide binding site [chemical binding]; other site
1229492003288	homodimer interface [polypeptide binding]; other site
1229492003289	Predicted membrane protein [Function unknown]; Region: COG1288
1229492003290	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1229492003291	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1229492003292	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1229492003293	gating phenylalanine in ion channel; other site
1229492003294	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
1229492003295	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
1229492003296	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1229492003297	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492003298	motif II; other site
1229492003299	hypothetical protein; Provisional; Region: PRK13688
1229492003300	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1229492003301	Coenzyme A binding pocket [chemical binding]; other site
1229492003302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1229492003303	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1229492003304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1229492003305	MraZ protein; Region: MraZ; pfam02381
1229492003306	MraZ protein; Region: MraZ; pfam02381
1229492003307	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1229492003308	MraW methylase family; Region: Methyltransf_5; pfam01795
1229492003309	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1229492003310	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229492003311	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229492003312	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229492003313	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1229492003314	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1229492003315	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1229492003316	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1229492003317	Mg++ binding site [ion binding]; other site
1229492003318	putative catalytic motif [active]
1229492003319	putative substrate binding site [chemical binding]; other site
1229492003320	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1229492003321	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229492003322	NAD binding site [chemical binding]; other site
1229492003323	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229492003324	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229492003325	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1229492003326	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1229492003327	Cell division protein FtsQ; Region: FtsQ; pfam03799
1229492003328	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1229492003329	Cell division protein FtsA; Region: FtsA; smart00842
1229492003330	Cell division protein FtsA; Region: FtsA; pfam14450
1229492003331	cell division protein FtsZ; Validated; Region: PRK09330
1229492003332	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1229492003333	nucleotide binding site [chemical binding]; other site
1229492003334	SulA interaction site; other site
1229492003335	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1229492003336	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1229492003337	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1229492003338	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229492003339	catalytic residue [active]
1229492003340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1229492003341	YGGT family; Region: YGGT; pfam02325
1229492003342	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1229492003343	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492003344	RNA binding surface [nucleotide binding]; other site
1229492003345	DivIVA protein; Region: DivIVA; pfam05103
1229492003346	DivIVA domain; Region: DivI1A_domain; TIGR03544
1229492003347	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1229492003348	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1229492003349	HIGH motif; other site
1229492003350	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229492003351	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1229492003352	active site
1229492003353	KMSKS motif; other site
1229492003354	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1229492003355	tRNA binding surface [nucleotide binding]; other site
1229492003356	anticodon binding site; other site
1229492003357	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1229492003358	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1229492003359	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229492003360	active site
1229492003361	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1229492003362	lipoprotein signal peptidase; Provisional; Region: PRK14787
1229492003363	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229492003364	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492003365	RNA binding surface [nucleotide binding]; other site
1229492003366	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229492003367	active site
1229492003368	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1229492003369	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1229492003370	uracil transporter; Provisional; Region: PRK10720
1229492003371	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1229492003372	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229492003373	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229492003374	dihydroorotase; Validated; Region: pyrC; PRK09357
1229492003375	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229492003376	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1229492003377	active site
1229492003378	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1229492003379	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1229492003380	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1229492003381	catalytic site [active]
1229492003382	subunit interface [polypeptide binding]; other site
1229492003383	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1229492003384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229492003385	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1229492003386	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1229492003387	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229492003388	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229492003389	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1229492003390	IMP binding site; other site
1229492003391	dimer interface [polypeptide binding]; other site
1229492003392	interdomain contacts; other site
1229492003393	partial ornithine binding site; other site
1229492003394	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1229492003395	active site
1229492003396	dimer interface [polypeptide binding]; other site
1229492003397	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492003398	active site
1229492003399	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1229492003400	dimer interface [polypeptide binding]; other site
1229492003401	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1229492003402	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1229492003403	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1229492003404	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1229492003405	catalytic site [active]
1229492003406	G-X2-G-X-G-K; other site
1229492003407	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1229492003408	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1229492003409	Flavoprotein; Region: Flavoprotein; pfam02441
1229492003410	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1229492003411	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1229492003412	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492003413	ATP binding site [chemical binding]; other site
1229492003414	putative Mg++ binding site [ion binding]; other site
1229492003415	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1229492003416	nucleotide binding region [chemical binding]; other site
1229492003417	ATP-binding site [chemical binding]; other site
1229492003418	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1229492003419	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1229492003420	active site
1229492003421	catalytic residues [active]
1229492003422	metal binding site [ion binding]; metal-binding site
1229492003423	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1229492003424	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1229492003425	putative active site [active]
1229492003426	substrate binding site [chemical binding]; other site
1229492003427	putative cosubstrate binding site; other site
1229492003428	catalytic site [active]
1229492003429	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1229492003430	substrate binding site [chemical binding]; other site
1229492003431	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1229492003432	NusB family; Region: NusB; pfam01029
1229492003433	putative RNA binding site [nucleotide binding]; other site
1229492003434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492003435	S-adenosylmethionine binding site [chemical binding]; other site
1229492003436	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1229492003437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492003438	FeS/SAM binding site; other site
1229492003439	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1229492003440	Protein phosphatase 2C; Region: PP2C; pfam00481
1229492003441	active site
1229492003442	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1229492003443	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1229492003444	active site
1229492003445	ATP binding site [chemical binding]; other site
1229492003446	substrate binding site [chemical binding]; other site
1229492003447	activation loop (A-loop); other site
1229492003448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1229492003449	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229492003450	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229492003451	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229492003452	Predicted GTPases [General function prediction only]; Region: COG1162
1229492003453	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1229492003454	RNA binding site [nucleotide binding]; other site
1229492003455	homodimer interface [polypeptide binding]; other site
1229492003456	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1229492003457	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1229492003458	GTP/Mg2+ binding site [chemical binding]; other site
1229492003459	G4 box; other site
1229492003460	G5 box; other site
1229492003461	G1 box; other site
1229492003462	Switch I region; other site
1229492003463	G2 box; other site
1229492003464	G3 box; other site
1229492003465	Switch II region; other site
1229492003466	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1229492003467	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1229492003468	substrate binding site [chemical binding]; other site
1229492003469	hexamer interface [polypeptide binding]; other site
1229492003470	metal binding site [ion binding]; metal-binding site
1229492003471	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1229492003472	Thiamine pyrophosphokinase; Region: TPK; cd07995
1229492003473	active site
1229492003474	dimerization interface [polypeptide binding]; other site
1229492003475	thiamine binding site [chemical binding]; other site
1229492003476	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1229492003477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1229492003478	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1229492003479	DAK2 domain; Region: Dak2; pfam02734
1229492003480	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1229492003481	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1229492003482	generic binding surface II; other site
1229492003483	ssDNA binding site; other site
1229492003484	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492003485	ATP binding site [chemical binding]; other site
1229492003486	putative Mg++ binding site [ion binding]; other site
1229492003487	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492003488	nucleotide binding region [chemical binding]; other site
1229492003489	ATP-binding site [chemical binding]; other site
1229492003490	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1229492003491	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1229492003492	active site 2 [active]
1229492003493	active site 1 [active]
1229492003494	putative phosphate acyltransferase; Provisional; Region: PRK05331
1229492003495	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1229492003496	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1229492003497	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229492003498	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1229492003499	NAD(P) binding site [chemical binding]; other site
1229492003500	homotetramer interface [polypeptide binding]; other site
1229492003501	homodimer interface [polypeptide binding]; other site
1229492003502	active site
1229492003503	acyl carrier protein; Provisional; Region: acpP; PRK00982
1229492003504	ribonuclease III; Reviewed; Region: rnc; PRK00102
1229492003505	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1229492003506	dimerization interface [polypeptide binding]; other site
1229492003507	active site
1229492003508	metal binding site [ion binding]; metal-binding site
1229492003509	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1229492003510	dsRNA binding site [nucleotide binding]; other site
1229492003511	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1229492003512	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1229492003513	Walker A/P-loop; other site
1229492003514	ATP binding site [chemical binding]; other site
1229492003515	Q-loop/lid; other site
1229492003516	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1229492003517	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1229492003518	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1229492003519	ABC transporter signature motif; other site
1229492003520	Walker B; other site
1229492003521	D-loop; other site
1229492003522	H-loop/switch region; other site
1229492003523	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1229492003524	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1229492003525	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1229492003526	P loop; other site
1229492003527	GTP binding site [chemical binding]; other site
1229492003528	putative DNA-binding protein; Validated; Region: PRK00118
1229492003529	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1229492003530	signal recognition particle protein; Provisional; Region: PRK10867
1229492003531	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1229492003532	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1229492003533	P loop; other site
1229492003534	GTP binding site [chemical binding]; other site
1229492003535	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1229492003536	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1229492003537	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1229492003538	RimM N-terminal domain; Region: RimM; pfam01782
1229492003539	PRC-barrel domain; Region: PRC; pfam05239
1229492003540	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1229492003541	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1229492003542	Predicted membrane protein [Function unknown]; Region: COG4485
1229492003543	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1229492003544	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1229492003545	GTP/Mg2+ binding site [chemical binding]; other site
1229492003546	G4 box; other site
1229492003547	G5 box; other site
1229492003548	G1 box; other site
1229492003549	Switch I region; other site
1229492003550	G2 box; other site
1229492003551	G3 box; other site
1229492003552	Switch II region; other site
1229492003553	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1229492003554	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229492003555	active site
1229492003556	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1229492003557	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1229492003558	CoA-ligase; Region: Ligase_CoA; pfam00549
1229492003559	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1229492003560	CoA binding domain; Region: CoA_binding; pfam02629
1229492003561	CoA-ligase; Region: Ligase_CoA; pfam00549
1229492003562	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
1229492003563	DNA protecting protein DprA; Region: dprA; TIGR00732
1229492003564	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1229492003565	DNA topoisomerase I; Validated; Region: PRK05582
1229492003566	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1229492003567	active site
1229492003568	interdomain interaction site; other site
1229492003569	putative metal-binding site [ion binding]; other site
1229492003570	nucleotide binding site [chemical binding]; other site
1229492003571	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1229492003572	domain I; other site
1229492003573	DNA binding groove [nucleotide binding]
1229492003574	phosphate binding site [ion binding]; other site
1229492003575	domain II; other site
1229492003576	domain III; other site
1229492003577	nucleotide binding site [chemical binding]; other site
1229492003578	catalytic site [active]
1229492003579	domain IV; other site
1229492003580	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1229492003581	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1229492003582	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1229492003583	Glucose inhibited division protein A; Region: GIDA; pfam01134
1229492003584	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1229492003585	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229492003586	active site
1229492003587	DNA binding site [nucleotide binding]
1229492003588	Int/Topo IB signature motif; other site
1229492003589	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1229492003590	active site
1229492003591	HslU subunit interaction site [polypeptide binding]; other site
1229492003592	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1229492003593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492003594	Walker A motif; other site
1229492003595	ATP binding site [chemical binding]; other site
1229492003596	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1229492003597	Walker B motif; other site
1229492003598	arginine finger; other site
1229492003599	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229492003600	transcriptional repressor CodY; Validated; Region: PRK04158
1229492003601	CodY GAF-like domain; Region: CodY; pfam06018
1229492003602	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1229492003603	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1229492003604	rRNA interaction site [nucleotide binding]; other site
1229492003605	S8 interaction site; other site
1229492003606	putative laminin-1 binding site; other site
1229492003607	elongation factor Ts; Provisional; Region: tsf; PRK09377
1229492003608	UBA/TS-N domain; Region: UBA; pfam00627
1229492003609	Elongation factor TS; Region: EF_TS; pfam00889
1229492003610	Elongation factor TS; Region: EF_TS; pfam00889
1229492003611	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1229492003612	putative nucleotide binding site [chemical binding]; other site
1229492003613	uridine monophosphate binding site [chemical binding]; other site
1229492003614	homohexameric interface [polypeptide binding]; other site
1229492003615	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1229492003616	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1229492003617	hinge region; other site
1229492003618	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1229492003619	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1229492003620	catalytic residue [active]
1229492003621	putative FPP diphosphate  binding site; other site
1229492003622	putative FPP binding hydrophobic cleft; other site
1229492003623	dimer interface [polypeptide binding]; other site
1229492003624	putative IPP diphosphate binding site; other site
1229492003625	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1229492003626	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1229492003627	RIP metalloprotease RseP; Region: TIGR00054
1229492003628	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1229492003629	active site
1229492003630	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1229492003631	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1229492003632	protein binding site [polypeptide binding]; other site
1229492003633	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1229492003634	putative substrate binding region [chemical binding]; other site
1229492003635	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1229492003636	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1229492003637	dimer interface [polypeptide binding]; other site
1229492003638	motif 1; other site
1229492003639	active site
1229492003640	motif 2; other site
1229492003641	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1229492003642	putative deacylase active site [active]
1229492003643	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229492003644	active site
1229492003645	motif 3; other site
1229492003646	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1229492003647	anticodon binding site; other site
1229492003648	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1229492003649	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1229492003650	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1229492003651	generic binding surface II; other site
1229492003652	generic binding surface I; other site
1229492003653	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1229492003654	active site
1229492003655	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1229492003656	active site
1229492003657	catalytic site [active]
1229492003658	substrate binding site [chemical binding]; other site
1229492003659	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1229492003660	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1229492003661	Sm and related proteins; Region: Sm_like; cl00259
1229492003662	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1229492003663	putative oligomer interface [polypeptide binding]; other site
1229492003664	putative RNA binding site [nucleotide binding]; other site
1229492003665	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1229492003666	NusA N-terminal domain; Region: NusA_N; pfam08529
1229492003667	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1229492003668	RNA binding site [nucleotide binding]; other site
1229492003669	homodimer interface [polypeptide binding]; other site
1229492003670	NusA-like KH domain; Region: KH_5; pfam13184
1229492003671	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1229492003672	G-X-X-G motif; other site
1229492003673	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1229492003674	putative RNA binding cleft [nucleotide binding]; other site
1229492003675	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1229492003676	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1229492003677	translation initiation factor IF-2; Region: IF-2; TIGR00487
1229492003678	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1229492003679	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1229492003680	G1 box; other site
1229492003681	putative GEF interaction site [polypeptide binding]; other site
1229492003682	GTP/Mg2+ binding site [chemical binding]; other site
1229492003683	Switch I region; other site
1229492003684	G2 box; other site
1229492003685	G3 box; other site
1229492003686	Switch II region; other site
1229492003687	G4 box; other site
1229492003688	G5 box; other site
1229492003689	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1229492003690	Translation-initiation factor 2; Region: IF-2; pfam11987
1229492003691	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1229492003692	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1229492003693	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
1229492003694	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1229492003695	RNA binding site [nucleotide binding]; other site
1229492003696	active site
1229492003697	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
1229492003698	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1229492003699	active site
1229492003700	Riboflavin kinase; Region: Flavokinase; smart00904
1229492003701	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1229492003702	16S/18S rRNA binding site [nucleotide binding]; other site
1229492003703	S13e-L30e interaction site [polypeptide binding]; other site
1229492003704	25S rRNA binding site [nucleotide binding]; other site
1229492003705	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1229492003706	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1229492003707	RNase E interface [polypeptide binding]; other site
1229492003708	trimer interface [polypeptide binding]; other site
1229492003709	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1229492003710	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1229492003711	RNase E interface [polypeptide binding]; other site
1229492003712	trimer interface [polypeptide binding]; other site
1229492003713	active site
1229492003714	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1229492003715	putative nucleic acid binding region [nucleotide binding]; other site
1229492003716	G-X-X-G motif; other site
1229492003717	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1229492003718	RNA binding site [nucleotide binding]; other site
1229492003719	domain interface; other site
1229492003720	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1229492003721	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229492003722	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1229492003723	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1229492003724	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229492003725	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229492003726	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229492003727	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1229492003728	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229492003729	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1229492003730	DNA-binding site [nucleotide binding]; DNA binding site
1229492003731	UTRA domain; Region: UTRA; pfam07702
1229492003732	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1229492003733	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1229492003734	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1229492003735	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1229492003736	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1229492003737	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1229492003738	classical (c) SDRs; Region: SDR_c; cd05233
1229492003739	NAD(P) binding site [chemical binding]; other site
1229492003740	active site
1229492003741	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1229492003742	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1229492003743	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1229492003744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492003745	non-specific DNA binding site [nucleotide binding]; other site
1229492003746	salt bridge; other site
1229492003747	sequence-specific DNA binding site [nucleotide binding]; other site
1229492003748	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1229492003749	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1229492003750	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1229492003751	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1229492003752	putative MPT binding site; other site
1229492003753	recombinase A; Provisional; Region: recA; PRK09354
1229492003754	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1229492003755	hexamer interface [polypeptide binding]; other site
1229492003756	Walker A motif; other site
1229492003757	ATP binding site [chemical binding]; other site
1229492003758	Walker B motif; other site
1229492003759	phosphodiesterase; Provisional; Region: PRK12704
1229492003760	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229492003761	Zn2+ binding site [ion binding]; other site
1229492003762	Mg2+ binding site [ion binding]; other site
1229492003763	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1229492003764	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229492003765	putative active site [active]
1229492003766	metal binding site [ion binding]; metal-binding site
1229492003767	homodimer binding site [polypeptide binding]; other site
1229492003768	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1229492003769	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1229492003770	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1229492003771	dimer interface [polypeptide binding]; other site
1229492003772	PYR/PP interface [polypeptide binding]; other site
1229492003773	TPP binding site [chemical binding]; other site
1229492003774	substrate binding site [chemical binding]; other site
1229492003775	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1229492003776	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1229492003777	TPP-binding site [chemical binding]; other site
1229492003778	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1229492003779	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229492003780	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229492003781	Integrase core domain; Region: rve; pfam00665
1229492003782	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1229492003783	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1229492003784	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1229492003785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492003786	FeS/SAM binding site; other site
1229492003787	TRAM domain; Region: TRAM; pfam01938
1229492003788	Predicted membrane protein [Function unknown]; Region: COG4550
1229492003789	Predicted membrane protein [Function unknown]; Region: COG4732
1229492003790	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1229492003791	MutS domain I; Region: MutS_I; pfam01624
1229492003792	MutS domain II; Region: MutS_II; pfam05188
1229492003793	MutS domain III; Region: MutS_III; pfam05192
1229492003794	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1229492003795	Walker A/P-loop; other site
1229492003796	ATP binding site [chemical binding]; other site
1229492003797	Q-loop/lid; other site
1229492003798	ABC transporter signature motif; other site
1229492003799	Walker B; other site
1229492003800	D-loop; other site
1229492003801	H-loop/switch region; other site
1229492003802	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1229492003803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492003804	ATP binding site [chemical binding]; other site
1229492003805	Mg2+ binding site [ion binding]; other site
1229492003806	G-X-G motif; other site
1229492003807	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1229492003808	ATP binding site [chemical binding]; other site
1229492003809	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1229492003810	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
1229492003811	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1229492003812	amphipathic channel; other site
1229492003813	Asn-Pro-Ala signature motifs; other site
1229492003814	glycerol kinase; Provisional; Region: glpK; PRK00047
1229492003815	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1229492003816	N- and C-terminal domain interface [polypeptide binding]; other site
1229492003817	active site
1229492003818	MgATP binding site [chemical binding]; other site
1229492003819	catalytic site [active]
1229492003820	metal binding site [ion binding]; metal-binding site
1229492003821	glycerol binding site [chemical binding]; other site
1229492003822	homotetramer interface [polypeptide binding]; other site
1229492003823	homodimer interface [polypeptide binding]; other site
1229492003824	FBP binding site [chemical binding]; other site
1229492003825	protein IIAGlc interface [polypeptide binding]; other site
1229492003826	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1229492003827	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1229492003828	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229492003829	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
1229492003830	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1229492003831	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1229492003832	bacterial Hfq-like; Region: Hfq; cd01716
1229492003833	hexamer interface [polypeptide binding]; other site
1229492003834	Sm1 motif; other site
1229492003835	RNA binding site [nucleotide binding]; other site
1229492003836	Sm2 motif; other site
1229492003837	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1229492003838	catalytic residues [active]
1229492003839	dimer interface [polypeptide binding]; other site
1229492003840	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1229492003841	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1229492003842	HflX GTPase family; Region: HflX; cd01878
1229492003843	G1 box; other site
1229492003844	GTP/Mg2+ binding site [chemical binding]; other site
1229492003845	Switch I region; other site
1229492003846	G2 box; other site
1229492003847	G3 box; other site
1229492003848	Switch II region; other site
1229492003849	G4 box; other site
1229492003850	G5 box; other site
1229492003851	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1229492003852	Aluminium resistance protein; Region: Alum_res; pfam06838
1229492003853	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1229492003854	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229492003855	DNA binding residues [nucleotide binding]
1229492003856	putative dimer interface [polypeptide binding]; other site
1229492003857	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1229492003858	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1229492003859	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1229492003860	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229492003861	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229492003862	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229492003863	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229492003864	Integrase core domain; Region: rve; pfam00665
1229492003865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229492003866	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1229492003867	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1229492003868	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229492003869	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492003870	catalytic residue [active]
1229492003871	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1229492003872	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1229492003873	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1229492003874	putative active site [active]
1229492003875	catalytic site [active]
1229492003876	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1229492003877	putative active site [active]
1229492003878	catalytic site [active]
1229492003879	Staphylococcal nuclease homologues; Region: SNc; smart00318
1229492003880	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1229492003881	Catalytic site; other site
1229492003882	AAA domain; Region: AAA_11; pfam13086
1229492003883	aspartate kinase; Reviewed; Region: PRK09034
1229492003884	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1229492003885	putative catalytic residues [active]
1229492003886	putative nucleotide binding site [chemical binding]; other site
1229492003887	putative aspartate binding site [chemical binding]; other site
1229492003888	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1229492003889	allosteric regulatory residue; other site
1229492003890	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1229492003891	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1229492003892	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1229492003893	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1229492003894	threonine synthase; Reviewed; Region: PRK06721
1229492003895	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1229492003896	homodimer interface [polypeptide binding]; other site
1229492003897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492003898	catalytic residue [active]
1229492003899	homoserine kinase; Provisional; Region: PRK01212
1229492003900	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229492003901	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1229492003902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492003903	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1229492003904	active site
1229492003905	motif I; other site
1229492003906	motif II; other site
1229492003907	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229492003908	lysine transporter; Provisional; Region: PRK10836
1229492003909	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1229492003910	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1229492003911	tetramer interface [polypeptide binding]; other site
1229492003912	heme binding pocket [chemical binding]; other site
1229492003913	NADPH binding site [chemical binding]; other site
1229492003914	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1229492003915	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1229492003916	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1229492003917	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1229492003918	active site
1229492003919	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1229492003920	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1229492003921	LexA repressor; Validated; Region: PRK00215
1229492003922	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229492003923	putative DNA binding site [nucleotide binding]; other site
1229492003924	putative Zn2+ binding site [ion binding]; other site
1229492003925	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1229492003926	Catalytic site [active]
1229492003927	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1229492003928	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1229492003929	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229492003930	TPP-binding site [chemical binding]; other site
1229492003931	dimer interface [polypeptide binding]; other site
1229492003932	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229492003933	PYR/PP interface [polypeptide binding]; other site
1229492003934	dimer interface [polypeptide binding]; other site
1229492003935	TPP binding site [chemical binding]; other site
1229492003936	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229492003937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1229492003938	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1229492003939	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1229492003940	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1229492003941	active site
1229492003942	metal binding site [ion binding]; metal-binding site
1229492003943	DNA binding site [nucleotide binding]
1229492003944	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1229492003945	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1229492003946	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1229492003947	Walker A/P-loop; other site
1229492003948	ATP binding site [chemical binding]; other site
1229492003949	Q-loop/lid; other site
1229492003950	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1229492003951	ABC transporter signature motif; other site
1229492003952	Walker B; other site
1229492003953	D-loop; other site
1229492003954	H-loop/switch region; other site
1229492003955	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1229492003956	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
1229492003957	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1229492003958	aconitate hydratase; Validated; Region: PRK09277
1229492003959	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1229492003960	substrate binding site [chemical binding]; other site
1229492003961	ligand binding site [chemical binding]; other site
1229492003962	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1229492003963	substrate binding site [chemical binding]; other site
1229492003964	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229492003965	active site
1229492003966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1229492003967	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1229492003968	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1229492003969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492003970	ATP binding site [chemical binding]; other site
1229492003971	Mg2+ binding site [ion binding]; other site
1229492003972	G-X-G motif; other site
1229492003973	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1229492003974	anchoring element; other site
1229492003975	dimer interface [polypeptide binding]; other site
1229492003976	ATP binding site [chemical binding]; other site
1229492003977	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1229492003978	active site
1229492003979	putative metal-binding site [ion binding]; other site
1229492003980	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1229492003981	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1229492003982	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1229492003983	CAP-like domain; other site
1229492003984	active site
1229492003985	primary dimer interface [polypeptide binding]; other site
1229492003986	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229492003987	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1229492003988	amino acid carrier protein; Region: agcS; TIGR00835
1229492003989	CAT RNA binding domain; Region: CAT_RBD; smart01061
1229492003990	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1229492003991	PRD domain; Region: PRD; pfam00874
1229492003992	PRD domain; Region: PRD; pfam00874
1229492003993	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229492003994	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229492003995	Predicted integral membrane protein [Function unknown]; Region: COG0392
1229492003996	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1229492003997	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1229492003998	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1229492003999	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1229492004000	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1229492004001	active site 1 [active]
1229492004002	dimer interface [polypeptide binding]; other site
1229492004003	hexamer interface [polypeptide binding]; other site
1229492004004	active site 2 [active]
1229492004005	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1229492004006	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1229492004007	active site
1229492004008	DNA binding site [nucleotide binding]
1229492004009	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1229492004010	prephenate dehydrogenase; Validated; Region: PRK06545
1229492004011	prephenate dehydrogenase; Validated; Region: PRK08507
1229492004012	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1229492004013	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1229492004014	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1229492004015	putative oligomer interface [polypeptide binding]; other site
1229492004016	putative active site [active]
1229492004017	metal binding site [ion binding]; metal-binding site
1229492004018	anthranilate synthase component I; Provisional; Region: PRK13567
1229492004019	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1229492004020	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1229492004021	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1229492004022	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1229492004023	glutamine binding [chemical binding]; other site
1229492004024	catalytic triad [active]
1229492004025	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1229492004026	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1229492004027	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1229492004028	active site
1229492004029	ribulose/triose binding site [chemical binding]; other site
1229492004030	phosphate binding site [ion binding]; other site
1229492004031	substrate (anthranilate) binding pocket [chemical binding]; other site
1229492004032	product (indole) binding pocket [chemical binding]; other site
1229492004033	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1229492004034	active site
1229492004035	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1229492004036	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1229492004037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492004038	catalytic residue [active]
1229492004039	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1229492004040	substrate binding site [chemical binding]; other site
1229492004041	active site
1229492004042	catalytic residues [active]
1229492004043	heterodimer interface [polypeptide binding]; other site
1229492004044	FemAB family; Region: FemAB; pfam02388
1229492004045	FlxA-like protein; Region: FlxA; pfam14282
1229492004046	FemAB family; Region: FemAB; pfam02388
1229492004047	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1229492004048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492004049	active site
1229492004050	motif I; other site
1229492004051	motif II; other site
1229492004052	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229492004053	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492004054	Walker A/P-loop; other site
1229492004055	ATP binding site [chemical binding]; other site
1229492004056	Q-loop/lid; other site
1229492004057	ABC transporter signature motif; other site
1229492004058	Walker B; other site
1229492004059	D-loop; other site
1229492004060	H-loop/switch region; other site
1229492004061	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492004062	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1229492004063	Walker A/P-loop; other site
1229492004064	ATP binding site [chemical binding]; other site
1229492004065	Q-loop/lid; other site
1229492004066	ABC transporter signature motif; other site
1229492004067	Walker B; other site
1229492004068	D-loop; other site
1229492004069	H-loop/switch region; other site
1229492004070	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1229492004071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492004072	dimer interface [polypeptide binding]; other site
1229492004073	conserved gate region; other site
1229492004074	putative PBP binding loops; other site
1229492004075	ABC-ATPase subunit interface; other site
1229492004076	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229492004077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492004078	dimer interface [polypeptide binding]; other site
1229492004079	conserved gate region; other site
1229492004080	putative PBP binding loops; other site
1229492004081	ABC-ATPase subunit interface; other site
1229492004082	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
1229492004083	oligoendopeptidase F; Region: pepF; TIGR00181
1229492004084	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1229492004085	active site
1229492004086	Zn binding site [ion binding]; other site
1229492004087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229492004088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229492004089	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1229492004090	PhoU domain; Region: PhoU; pfam01895
1229492004091	PhoU domain; Region: PhoU; pfam01895
1229492004092	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1229492004093	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1229492004094	Walker A/P-loop; other site
1229492004095	ATP binding site [chemical binding]; other site
1229492004096	Q-loop/lid; other site
1229492004097	ABC transporter signature motif; other site
1229492004098	Walker B; other site
1229492004099	D-loop; other site
1229492004100	H-loop/switch region; other site
1229492004101	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1229492004102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492004103	dimer interface [polypeptide binding]; other site
1229492004104	conserved gate region; other site
1229492004105	putative PBP binding loops; other site
1229492004106	ABC-ATPase subunit interface; other site
1229492004107	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1229492004108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492004109	dimer interface [polypeptide binding]; other site
1229492004110	conserved gate region; other site
1229492004111	ABC-ATPase subunit interface; other site
1229492004112	phosphate binding protein; Region: ptsS_2; TIGR02136
1229492004113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229492004114	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229492004115	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1229492004116	S1 domain; Region: S1_2; pfam13509
1229492004117	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1229492004118	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492004119	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492004120	ABC transporter; Region: ABC_tran_2; pfam12848
1229492004121	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492004122	aspartate kinase; Reviewed; Region: PRK06635
1229492004123	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1229492004124	putative nucleotide binding site [chemical binding]; other site
1229492004125	putative catalytic residues [active]
1229492004126	putative Mg ion binding site [ion binding]; other site
1229492004127	putative aspartate binding site [chemical binding]; other site
1229492004128	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
1229492004129	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1229492004130	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1229492004131	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229492004132	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1229492004133	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229492004134	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1229492004135	dimer interface [polypeptide binding]; other site
1229492004136	active site
1229492004137	catalytic residue [active]
1229492004138	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1229492004139	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1229492004140	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1229492004141	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1229492004142	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1229492004143	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1229492004144	active site
1229492004145	trimer interface [polypeptide binding]; other site
1229492004146	substrate binding site [chemical binding]; other site
1229492004147	CoA binding site [chemical binding]; other site
1229492004148	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229492004149	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1229492004150	metal binding site [ion binding]; metal-binding site
1229492004151	dimer interface [polypeptide binding]; other site
1229492004152	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1229492004153	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1229492004154	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229492004155	catalytic residue [active]
1229492004156	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1229492004157	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1229492004158	active site
1229492004159	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229492004160	substrate binding site [chemical binding]; other site
1229492004161	catalytic residues [active]
1229492004162	dimer interface [polypeptide binding]; other site
1229492004163	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1229492004164	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229492004165	DNA-binding site [nucleotide binding]; DNA binding site
1229492004166	RNA-binding motif; other site
1229492004167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
1229492004168	acylphosphatase; Provisional; Region: PRK14431
1229492004169	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1229492004170	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
1229492004171	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1229492004172	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1229492004173	metal ion-dependent adhesion site (MIDAS); other site
1229492004174	MoxR-like ATPases [General function prediction only]; Region: COG0714
1229492004175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492004176	Walker A motif; other site
1229492004177	ATP binding site [chemical binding]; other site
1229492004178	Walker B motif; other site
1229492004179	arginine finger; other site
1229492004180	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229492004181	active site
1229492004182	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229492004183	active site
1229492004184	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1229492004185	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229492004186	E3 interaction surface; other site
1229492004187	lipoyl attachment site [posttranslational modification]; other site
1229492004188	e3 binding domain; Region: E3_binding; pfam02817
1229492004189	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1229492004190	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1229492004191	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1229492004192	TPP-binding site [chemical binding]; other site
1229492004193	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
1229492004194	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1229492004195	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229492004196	HAMP domain; Region: HAMP; pfam00672
1229492004197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492004198	dimer interface [polypeptide binding]; other site
1229492004199	phosphorylation site [posttranslational modification]
1229492004200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492004201	ATP binding site [chemical binding]; other site
1229492004202	Mg2+ binding site [ion binding]; other site
1229492004203	G-X-G motif; other site
1229492004204	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492004205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492004206	active site
1229492004207	phosphorylation site [posttranslational modification]
1229492004208	intermolecular recognition site; other site
1229492004209	dimerization interface [polypeptide binding]; other site
1229492004210	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492004211	DNA binding site [nucleotide binding]
1229492004212	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229492004213	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1229492004214	active site
1229492004215	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1229492004216	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1229492004217	active site
1229492004218	homodimer interface [polypeptide binding]; other site
1229492004219	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229492004220	Coenzyme A binding pocket [chemical binding]; other site
1229492004221	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1229492004222	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1229492004223	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1229492004224	protein binding site [polypeptide binding]; other site
1229492004225	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1229492004226	Catalytic dyad [active]
1229492004227	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1229492004228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
1229492004229	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1229492004230	HPr interaction site; other site
1229492004231	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229492004232	active site
1229492004233	phosphorylation site [posttranslational modification]
1229492004234	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1229492004235	SelR domain; Region: SelR; pfam01641
1229492004236	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1229492004237	EDD domain protein, DegV family; Region: DegV; TIGR00762
1229492004238	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1229492004239	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1229492004240	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1229492004241	folate binding site [chemical binding]; other site
1229492004242	NADP+ binding site [chemical binding]; other site
1229492004243	thymidylate synthase; Region: thym_sym; TIGR03284
1229492004244	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1229492004245	dimerization interface [polypeptide binding]; other site
1229492004246	active site
1229492004247	Disulphide isomerase; Region: Disulph_isomer; cl05813
1229492004248	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1229492004249	Virulence factor; Region: Virulence_fact; pfam13769
1229492004250	HEAT repeats; Region: HEAT_2; pfam13646
1229492004251	HEAT repeat; Region: HEAT; pfam02985
1229492004252	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
1229492004253	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1229492004254	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1229492004255	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1229492004256	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229492004257	active site
1229492004258	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492004259	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
1229492004260	GA module; Region: GA; smart00844
1229492004261	GA module; Region: GA; smart00844
1229492004262	GA module; Region: GA; smart00844
1229492004263	GA module; Region: GA; smart00844
1229492004264	GA module; Region: GA; smart00844
1229492004265	GA module; Region: GA; smart00844
1229492004266	GA module; Region: GA; smart00844
1229492004267	GA module; Region: GA; smart00844
1229492004268	GA module; Region: GA; smart00844
1229492004269	GA module; Region: GA; smart00844
1229492004270	GA module; Region: GA; smart00844
1229492004271	GA module; Region: GA; smart00844
1229492004272	GA module; Region: GA; smart00844
1229492004273	GA module; Region: GA; smart00844
1229492004274	GA module; Region: GA; smart00844
1229492004275	GA module; Region: GA; smart00844
1229492004276	GA module; Region: GA; smart00844
1229492004277	GA module; Region: GA; smart00844
1229492004278	Predicted membrane protein [Function unknown]; Region: COG1511
1229492004279	GA module; Region: GA; smart00844
1229492004280	GA module; Region: GA; smart00844
1229492004281	GA module; Region: GA; smart00844
1229492004282	GA module; Region: GA; smart00844
1229492004283	GA module; Region: GA; smart00844
1229492004284	GA module; Region: GA; pfam01468
1229492004285	GA module; Region: GA; smart00844
1229492004286	GA module; Region: GA; smart00844
1229492004287	GA module; Region: GA; smart00844
1229492004288	GA module; Region: GA; smart00844
1229492004289	GA module; Region: GA; smart00844
1229492004290	GA module; Region: GA; smart00844
1229492004291	GA module; Region: GA; smart00844
1229492004292	GA module; Region: GA; smart00844
1229492004293	GA module; Region: GA; smart00844
1229492004294	GA module; Region: GA; smart00844
1229492004295	GA module; Region: GA; smart00844
1229492004296	GA module; Region: GA; smart00844
1229492004297	GA module; Region: GA; smart00844
1229492004298	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1229492004299	GA module; Region: GA; smart00844
1229492004300	GA module; Region: GA; smart00844
1229492004301	GA module; Region: GA; smart00844
1229492004302	GA module; Region: GA; smart00844
1229492004303	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492004304	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492004305	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492004306	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492004307	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492004308	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229492004309	Amino acid permease; Region: AA_permease_2; pfam13520
1229492004310	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1229492004311	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229492004312	tetramer interface [polypeptide binding]; other site
1229492004313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492004314	catalytic residue [active]
1229492004315	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1229492004316	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1229492004317	hexamer interface [polypeptide binding]; other site
1229492004318	ligand binding site [chemical binding]; other site
1229492004319	putative active site [active]
1229492004320	NAD(P) binding site [chemical binding]; other site
1229492004321	5'-3' exonuclease; Region: 53EXOc; smart00475
1229492004322	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1229492004323	active site
1229492004324	metal binding site 1 [ion binding]; metal-binding site
1229492004325	putative 5' ssDNA interaction site; other site
1229492004326	metal binding site 3; metal-binding site
1229492004327	metal binding site 2 [ion binding]; metal-binding site
1229492004328	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1229492004329	putative DNA binding site [nucleotide binding]; other site
1229492004330	putative metal binding site [ion binding]; other site
1229492004331	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1229492004332	Dynamin family; Region: Dynamin_N; pfam00350
1229492004333	G1 box; other site
1229492004334	GTP/Mg2+ binding site [chemical binding]; other site
1229492004335	G2 box; other site
1229492004336	Switch I region; other site
1229492004337	G3 box; other site
1229492004338	Switch II region; other site
1229492004339	G4 box; other site
1229492004340	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1229492004341	Dynamin family; Region: Dynamin_N; pfam00350
1229492004342	G1 box; other site
1229492004343	GTP/Mg2+ binding site [chemical binding]; other site
1229492004344	G2 box; other site
1229492004345	Switch I region; other site
1229492004346	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1229492004347	G3 box; other site
1229492004348	Switch II region; other site
1229492004349	GTP/Mg2+ binding site [chemical binding]; other site
1229492004350	G4 box; other site
1229492004351	G5 box; other site
1229492004352	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1229492004353	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1229492004354	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1229492004355	Cobalt transport protein component CbiN; Region: CbiN; cl00842
1229492004356	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1229492004357	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1229492004358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229492004359	cell division protein GpsB; Provisional; Region: PRK14127
1229492004360	DivIVA domain; Region: DivI1A_domain; TIGR03544
1229492004361	hypothetical protein; Provisional; Region: PRK13660
1229492004362	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1229492004363	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1229492004364	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1229492004365	Transglycosylase; Region: Transgly; pfam00912
1229492004366	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229492004367	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1229492004368	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229492004369	minor groove reading motif; other site
1229492004370	helix-hairpin-helix signature motif; other site
1229492004371	substrate binding pocket [chemical binding]; other site
1229492004372	active site
1229492004373	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1229492004374	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1229492004375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1229492004376	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1229492004377	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1229492004378	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1229492004379	putative dimer interface [polypeptide binding]; other site
1229492004380	putative anticodon binding site; other site
1229492004381	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1229492004382	homodimer interface [polypeptide binding]; other site
1229492004383	motif 1; other site
1229492004384	motif 2; other site
1229492004385	active site
1229492004386	motif 3; other site
1229492004387	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1229492004388	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1229492004389	active site
1229492004390	catalytic site [active]
1229492004391	substrate binding site [chemical binding]; other site
1229492004392	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1229492004393	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1229492004394	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1229492004395	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1229492004396	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1229492004397	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1229492004398	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1229492004399	active site
1229492004400	NTP binding site [chemical binding]; other site
1229492004401	metal binding triad [ion binding]; metal-binding site
1229492004402	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1229492004403	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1229492004404	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1229492004405	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1229492004406	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1229492004407	homodimer interface [polypeptide binding]; other site
1229492004408	metal binding site [ion binding]; metal-binding site
1229492004409	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1229492004410	Predicted membrane protein [Function unknown]; Region: COG4347
1229492004411	Uncharacterized conserved protein [Function unknown]; Region: COG5582
1229492004412	UPF0302 domain; Region: UPF0302; pfam08864
1229492004413	A short protein domain of unknown function; Region: IDEAL; smart00914
1229492004414	TPR repeat; Region: TPR_11; pfam13414
1229492004415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229492004416	binding surface
1229492004417	TPR motif; other site
1229492004418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229492004419	TPR motif; other site
1229492004420	binding surface
1229492004421	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1229492004422	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1229492004423	hinge; other site
1229492004424	active site
1229492004425	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1229492004426	active site
1229492004427	NAD binding site [chemical binding]; other site
1229492004428	metal binding site [ion binding]; metal-binding site
1229492004429	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1229492004430	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1229492004431	Tetramer interface [polypeptide binding]; other site
1229492004432	active site
1229492004433	FMN-binding site [chemical binding]; other site
1229492004434	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1229492004435	active site
1229492004436	multimer interface [polypeptide binding]; other site
1229492004437	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1229492004438	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1229492004439	substrate binding pocket [chemical binding]; other site
1229492004440	chain length determination region; other site
1229492004441	substrate-Mg2+ binding site; other site
1229492004442	catalytic residues [active]
1229492004443	aspartate-rich region 1; other site
1229492004444	active site lid residues [active]
1229492004445	aspartate-rich region 2; other site
1229492004446	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1229492004447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492004448	S-adenosylmethionine binding site [chemical binding]; other site
1229492004449	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1229492004450	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229492004451	IHF dimer interface [polypeptide binding]; other site
1229492004452	IHF - DNA interface [nucleotide binding]; other site
1229492004453	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1229492004454	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1229492004455	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1229492004456	GTP-binding protein Der; Reviewed; Region: PRK00093
1229492004457	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1229492004458	G1 box; other site
1229492004459	GTP/Mg2+ binding site [chemical binding]; other site
1229492004460	Switch I region; other site
1229492004461	G2 box; other site
1229492004462	Switch II region; other site
1229492004463	G3 box; other site
1229492004464	G4 box; other site
1229492004465	G5 box; other site
1229492004466	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1229492004467	G1 box; other site
1229492004468	GTP/Mg2+ binding site [chemical binding]; other site
1229492004469	Switch I region; other site
1229492004470	G2 box; other site
1229492004471	G3 box; other site
1229492004472	Switch II region; other site
1229492004473	G4 box; other site
1229492004474	G5 box; other site
1229492004475	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1229492004476	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1229492004477	RNA binding site [nucleotide binding]; other site
1229492004478	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1229492004479	RNA binding site [nucleotide binding]; other site
1229492004480	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1229492004481	RNA binding site [nucleotide binding]; other site
1229492004482	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1229492004483	RNA binding site [nucleotide binding]; other site
1229492004484	cytidylate kinase; Provisional; Region: cmk; PRK00023
1229492004485	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1229492004486	CMP-binding site; other site
1229492004487	The sites determining sugar specificity; other site
1229492004488	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1229492004489	active site
1229492004490	homotetramer interface [polypeptide binding]; other site
1229492004491	homodimer interface [polypeptide binding]; other site
1229492004492	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1229492004493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1229492004494	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492004495	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229492004496	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1229492004497	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229492004498	ATP binding site [chemical binding]; other site
1229492004499	putative Mg++ binding site [ion binding]; other site
1229492004500	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492004501	nucleotide binding region [chemical binding]; other site
1229492004502	ATP-binding site [chemical binding]; other site
1229492004503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1229492004504	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1229492004505	Predicted membrane protein [Function unknown]; Region: COG3601
1229492004506	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1229492004507	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1229492004508	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1229492004509	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1229492004510	V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496
1229492004511	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1229492004512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229492004513	dimerization interface [polypeptide binding]; other site
1229492004514	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229492004515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492004516	dimer interface [polypeptide binding]; other site
1229492004517	phosphorylation site [posttranslational modification]
1229492004518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492004519	ATP binding site [chemical binding]; other site
1229492004520	Mg2+ binding site [ion binding]; other site
1229492004521	G-X-G motif; other site
1229492004522	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492004523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492004524	active site
1229492004525	phosphorylation site [posttranslational modification]
1229492004526	intermolecular recognition site; other site
1229492004527	dimerization interface [polypeptide binding]; other site
1229492004528	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492004529	DNA binding site [nucleotide binding]
1229492004530	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1229492004531	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492004532	RNA binding surface [nucleotide binding]; other site
1229492004533	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1229492004534	active site
1229492004535	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1229492004536	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1229492004537	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1229492004538	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1229492004539	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1229492004540	active site
1229492004541	Int/Topo IB signature motif; other site
1229492004542	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1229492004543	metal binding site 2 [ion binding]; metal-binding site
1229492004544	putative DNA binding helix; other site
1229492004545	metal binding site 1 [ion binding]; metal-binding site
1229492004546	dimer interface [polypeptide binding]; other site
1229492004547	structural Zn2+ binding site [ion binding]; other site
1229492004548	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1229492004549	dimer interface [polypeptide binding]; other site
1229492004550	ADP-ribose binding site [chemical binding]; other site
1229492004551	active site
1229492004552	nudix motif; other site
1229492004553	metal binding site [ion binding]; metal-binding site
1229492004554	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229492004555	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229492004556	active site
1229492004557	catalytic tetrad [active]
1229492004558	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1229492004559	classical (c) SDRs; Region: SDR_c; cd05233
1229492004560	NAD(P) binding site [chemical binding]; other site
1229492004561	active site
1229492004562	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1229492004563	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1229492004564	ribonuclease Z; Region: RNase_Z; TIGR02651
1229492004565	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1229492004566	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1229492004567	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1229492004568	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229492004569	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1229492004570	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229492004571	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1229492004572	Ca binding site [ion binding]; other site
1229492004573	active site
1229492004574	catalytic site [active]
1229492004575	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229492004576	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229492004577	DNA binding site [nucleotide binding]
1229492004578	domain linker motif; other site
1229492004579	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1229492004580	putative ligand binding site [chemical binding]; other site
1229492004581	putative dimerization interface [polypeptide binding]; other site
1229492004582	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229492004583	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1229492004584	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229492004585	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1229492004586	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1229492004587	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1229492004588	peptidase T-like protein; Region: PepT-like; TIGR01883
1229492004589	metal binding site [ion binding]; metal-binding site
1229492004590	putative dimer interface [polypeptide binding]; other site
1229492004591	Predicted membrane protein [Function unknown]; Region: COG4129
1229492004592	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1229492004593	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1229492004594	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1229492004595	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229492004596	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1229492004597	E3 interaction surface; other site
1229492004598	lipoyl attachment site [posttranslational modification]; other site
1229492004599	e3 binding domain; Region: E3_binding; pfam02817
1229492004600	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1229492004601	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1229492004602	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1229492004603	alpha subunit interface [polypeptide binding]; other site
1229492004604	TPP binding site [chemical binding]; other site
1229492004605	heterodimer interface [polypeptide binding]; other site
1229492004606	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229492004607	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1229492004608	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1229492004609	tetramer interface [polypeptide binding]; other site
1229492004610	TPP-binding site [chemical binding]; other site
1229492004611	heterodimer interface [polypeptide binding]; other site
1229492004612	phosphorylation loop region [posttranslational modification]
1229492004613	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1229492004614	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1229492004615	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492004616	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229492004617	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1229492004618	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1229492004619	Walker A/P-loop; other site
1229492004620	ATP binding site [chemical binding]; other site
1229492004621	Q-loop/lid; other site
1229492004622	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1229492004623	ABC transporter signature motif; other site
1229492004624	Walker B; other site
1229492004625	D-loop; other site
1229492004626	H-loop/switch region; other site
1229492004627	arginine repressor; Provisional; Region: PRK04280
1229492004628	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1229492004629	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1229492004630	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1229492004631	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1229492004632	substrate binding pocket [chemical binding]; other site
1229492004633	chain length determination region; other site
1229492004634	substrate-Mg2+ binding site; other site
1229492004635	catalytic residues [active]
1229492004636	aspartate-rich region 1; other site
1229492004637	active site lid residues [active]
1229492004638	aspartate-rich region 2; other site
1229492004639	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
1229492004640	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1229492004641	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1229492004642	generic binding surface II; other site
1229492004643	generic binding surface I; other site
1229492004644	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1229492004645	putative RNA binding site [nucleotide binding]; other site
1229492004646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1229492004647	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1229492004648	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229492004649	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1229492004650	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1229492004651	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1229492004652	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229492004653	carboxyltransferase (CT) interaction site; other site
1229492004654	biotinylation site [posttranslational modification]; other site
1229492004655	elongation factor P; Validated; Region: PRK00529
1229492004656	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1229492004657	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1229492004658	RNA binding site [nucleotide binding]; other site
1229492004659	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1229492004660	RNA binding site [nucleotide binding]; other site
1229492004661	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229492004662	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229492004663	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1229492004664	active site
1229492004665	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1229492004666	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1229492004667	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1229492004668	active site residue [active]
1229492004669	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1229492004670	tetramer interface [polypeptide binding]; other site
1229492004671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492004672	catalytic residue [active]
1229492004673	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1229492004674	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1229492004675	tetramer interface [polypeptide binding]; other site
1229492004676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492004677	catalytic residue [active]
1229492004678	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1229492004679	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1229492004680	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1229492004681	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1229492004682	ADP binding site [chemical binding]; other site
1229492004683	magnesium binding site [ion binding]; other site
1229492004684	putative shikimate binding site; other site
1229492004685	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1229492004686	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1229492004687	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1229492004688	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1229492004689	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1229492004690	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229492004691	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229492004692	Type II/IV secretion system protein; Region: T2SE; pfam00437
1229492004693	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229492004694	Walker A motif; other site
1229492004695	ATP binding site [chemical binding]; other site
1229492004696	Walker B motif; other site
1229492004697	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229492004698	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1229492004699	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1229492004700	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229492004701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
1229492004702	Rhomboid family; Region: Rhomboid; pfam01694
1229492004703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229492004704	binding surface
1229492004705	TPR motif; other site
1229492004706	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1229492004707	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1229492004708	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1229492004709	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1229492004710	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229492004711	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229492004712	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229492004713	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1229492004714	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1229492004715	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1229492004716	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1229492004717	metal binding site 2 [ion binding]; metal-binding site
1229492004718	putative DNA binding helix; other site
1229492004719	metal binding site 1 [ion binding]; metal-binding site
1229492004720	dimer interface [polypeptide binding]; other site
1229492004721	structural Zn2+ binding site [ion binding]; other site
1229492004722	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1229492004723	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492004724	ABC-ATPase subunit  interface; other site
1229492004725	dimer interface [polypeptide binding]; other site
1229492004726	putative PBP binding regions; other site
1229492004727	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1229492004728	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1229492004729	endonuclease IV; Provisional; Region: PRK01060
1229492004730	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1229492004731	AP (apurinic/apyrimidinic) site pocket; other site
1229492004732	DNA interaction; other site
1229492004733	Metal-binding active site; metal-binding site
1229492004734	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1229492004735	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229492004736	ATP binding site [chemical binding]; other site
1229492004737	putative Mg++ binding site [ion binding]; other site
1229492004738	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492004739	nucleotide binding region [chemical binding]; other site
1229492004740	ATP-binding site [chemical binding]; other site
1229492004741	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1229492004742	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1229492004743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1229492004744	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1229492004745	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1229492004746	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1229492004747	Family of unknown function (DUF633); Region: DUF633; pfam04816
1229492004748	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1229492004749	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1229492004750	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1229492004751	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229492004752	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229492004753	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229492004754	DNA binding residues [nucleotide binding]
1229492004755	DNA primase, catalytic core; Region: dnaG; TIGR01391
1229492004756	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1229492004757	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1229492004758	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1229492004759	active site
1229492004760	metal binding site [ion binding]; metal-binding site
1229492004761	interdomain interaction site; other site
1229492004762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
1229492004763	FOG: CBS domain [General function prediction only]; Region: COG0517
1229492004764	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1229492004765	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1229492004766	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229492004767	motif 1; other site
1229492004768	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1229492004769	active site
1229492004770	motif 2; other site
1229492004771	motif 3; other site
1229492004772	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1229492004773	anticodon binding site; other site
1229492004774	DNA repair protein RecO; Region: reco; TIGR00613
1229492004775	Recombination protein O N terminal; Region: RecO_N; pfam11967
1229492004776	Recombination protein O C terminal; Region: RecO_C; pfam02565
1229492004777	GTPase Era; Reviewed; Region: era; PRK00089
1229492004778	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1229492004779	G1 box; other site
1229492004780	GTP/Mg2+ binding site [chemical binding]; other site
1229492004781	Switch I region; other site
1229492004782	G2 box; other site
1229492004783	Switch II region; other site
1229492004784	G3 box; other site
1229492004785	G4 box; other site
1229492004786	G5 box; other site
1229492004787	KH domain; Region: KH_2; pfam07650
1229492004788	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1229492004789	active site
1229492004790	catalytic motif [active]
1229492004791	Zn binding site [ion binding]; other site
1229492004792	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1229492004793	metal-binding heat shock protein; Provisional; Region: PRK00016
1229492004794	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1229492004795	PhoH-like protein; Region: PhoH; pfam02562
1229492004796	hypothetical protein; Provisional; Region: PRK13665
1229492004797	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1229492004798	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1229492004799	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1229492004800	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1229492004801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492004802	FeS/SAM binding site; other site
1229492004803	TRAM domain; Region: TRAM; cl01282
1229492004804	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1229492004805	RNA methyltransferase, RsmE family; Region: TIGR00046
1229492004806	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1229492004807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492004808	S-adenosylmethionine binding site [chemical binding]; other site
1229492004809	chaperone protein DnaJ; Provisional; Region: PRK14280
1229492004810	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1229492004811	HSP70 interaction site [polypeptide binding]; other site
1229492004812	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1229492004813	substrate binding site [polypeptide binding]; other site
1229492004814	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1229492004815	Zn binding sites [ion binding]; other site
1229492004816	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1229492004817	dimer interface [polypeptide binding]; other site
1229492004818	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1229492004819	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1229492004820	nucleotide binding site [chemical binding]; other site
1229492004821	NEF interaction site [polypeptide binding]; other site
1229492004822	SBD interface [polypeptide binding]; other site
1229492004823	heat shock protein GrpE; Provisional; Region: PRK14140
1229492004824	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1229492004825	dimer interface [polypeptide binding]; other site
1229492004826	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1229492004827	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1229492004828	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
1229492004829	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1229492004830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492004831	FeS/SAM binding site; other site
1229492004832	HemN C-terminal domain; Region: HemN_C; pfam06969
1229492004833	GTP-binding protein LepA; Provisional; Region: PRK05433
1229492004834	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1229492004835	G1 box; other site
1229492004836	putative GEF interaction site [polypeptide binding]; other site
1229492004837	GTP/Mg2+ binding site [chemical binding]; other site
1229492004838	Switch I region; other site
1229492004839	G2 box; other site
1229492004840	G3 box; other site
1229492004841	Switch II region; other site
1229492004842	G4 box; other site
1229492004843	G5 box; other site
1229492004844	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1229492004845	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1229492004846	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1229492004847	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1229492004848	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1229492004849	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1229492004850	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1229492004851	Competence protein; Region: Competence; pfam03772
1229492004852	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1229492004853	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229492004854	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1229492004855	catalytic motif [active]
1229492004856	Zn binding site [ion binding]; other site
1229492004857	comEA protein; Region: comE; TIGR01259
1229492004858	Helix-hairpin-helix motif; Region: HHH; pfam00633
1229492004859	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229492004860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492004861	S-adenosylmethionine binding site [chemical binding]; other site
1229492004862	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1229492004863	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229492004864	Zn2+ binding site [ion binding]; other site
1229492004865	Mg2+ binding site [ion binding]; other site
1229492004866	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1229492004867	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1229492004868	active site
1229492004869	(T/H)XGH motif; other site
1229492004870	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1229492004871	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1229492004872	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1229492004873	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1229492004874	shikimate binding site; other site
1229492004875	NAD(P) binding site [chemical binding]; other site
1229492004876	GTPase YqeH; Provisional; Region: PRK13796
1229492004877	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1229492004878	GTP/Mg2+ binding site [chemical binding]; other site
1229492004879	G4 box; other site
1229492004880	G5 box; other site
1229492004881	G1 box; other site
1229492004882	Switch I region; other site
1229492004883	G2 box; other site
1229492004884	G3 box; other site
1229492004885	Switch II region; other site
1229492004886	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1229492004887	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492004888	active site
1229492004889	motif I; other site
1229492004890	motif II; other site
1229492004891	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1229492004892	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1229492004893	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1229492004894	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1229492004895	Fic family protein [Function unknown]; Region: COG3177
1229492004896	Fic/DOC family; Region: Fic; pfam02661
1229492004897	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1229492004898	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1229492004899	putative active site [active]
1229492004900	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229492004901	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1229492004902	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229492004903	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1229492004904	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1229492004905	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229492004906	carboxyltransferase (CT) interaction site; other site
1229492004907	biotinylation site [posttranslational modification]; other site
1229492004908	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1229492004909	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1229492004910	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1229492004911	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1229492004912	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1229492004913	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1229492004914	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1229492004915	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1229492004916	Sugar specificity; other site
1229492004917	Pyrimidine base specificity; other site
1229492004918	ATP-binding site [chemical binding]; other site
1229492004919	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1229492004920	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229492004921	Peptidase family U32; Region: Peptidase_U32; pfam01136
1229492004922	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1229492004923	Peptidase family U32; Region: Peptidase_U32; pfam01136
1229492004924	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1229492004925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492004926	S-adenosylmethionine binding site [chemical binding]; other site
1229492004927	hypothetical protein; Provisional; Region: PRK13678
1229492004928	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
1229492004929	hypothetical protein; Provisional; Region: PRK05473
1229492004930	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1229492004931	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1229492004932	motif 1; other site
1229492004933	active site
1229492004934	motif 2; other site
1229492004935	motif 3; other site
1229492004936	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1229492004937	DHHA1 domain; Region: DHHA1; pfam02272
1229492004938	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1229492004939	AAA domain; Region: AAA_30; pfam13604
1229492004940	Family description; Region: UvrD_C_2; pfam13538
1229492004941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229492004942	binding surface
1229492004943	TPR motif; other site
1229492004944	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1229492004945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229492004946	binding surface
1229492004947	TPR motif; other site
1229492004948	TPR repeat; Region: TPR_11; pfam13414
1229492004949	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1229492004950	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1229492004951	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1229492004952	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1229492004953	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492004954	catalytic residue [active]
1229492004955	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1229492004956	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1229492004957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1229492004958	Predicted transcriptional regulator [Transcription]; Region: COG1959
1229492004959	Transcriptional regulator; Region: Rrf2; pfam02082
1229492004960	recombination factor protein RarA; Reviewed; Region: PRK13342
1229492004961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492004962	Walker A motif; other site
1229492004963	ATP binding site [chemical binding]; other site
1229492004964	Walker B motif; other site
1229492004965	arginine finger; other site
1229492004966	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1229492004967	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1229492004968	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1229492004969	putative ATP binding site [chemical binding]; other site
1229492004970	putative substrate interface [chemical binding]; other site
1229492004971	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1229492004972	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1229492004973	dimer interface [polypeptide binding]; other site
1229492004974	anticodon binding site; other site
1229492004975	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1229492004976	homodimer interface [polypeptide binding]; other site
1229492004977	motif 1; other site
1229492004978	active site
1229492004979	motif 2; other site
1229492004980	GAD domain; Region: GAD; pfam02938
1229492004981	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1229492004982	motif 3; other site
1229492004983	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1229492004984	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1229492004985	dimer interface [polypeptide binding]; other site
1229492004986	motif 1; other site
1229492004987	active site
1229492004988	motif 2; other site
1229492004989	motif 3; other site
1229492004990	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1229492004991	anticodon binding site; other site
1229492004992	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1229492004993	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1229492004994	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1229492004995	active site
1229492004996	metal binding site [ion binding]; metal-binding site
1229492004997	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1229492004998	putative active site [active]
1229492004999	dimerization interface [polypeptide binding]; other site
1229492005000	putative tRNAtyr binding site [nucleotide binding]; other site
1229492005001	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1229492005002	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229492005003	Zn2+ binding site [ion binding]; other site
1229492005004	Mg2+ binding site [ion binding]; other site
1229492005005	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229492005006	synthetase active site [active]
1229492005007	NTP binding site [chemical binding]; other site
1229492005008	metal binding site [ion binding]; metal-binding site
1229492005009	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1229492005010	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1229492005011	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492005012	active site
1229492005013	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1229492005014	DHH family; Region: DHH; pfam01368
1229492005015	DHHA1 domain; Region: DHHA1; pfam02272
1229492005016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1229492005017	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1229492005018	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1229492005019	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1229492005020	Protein export membrane protein; Region: SecD_SecF; pfam02355
1229492005021	Preprotein translocase subunit; Region: YajC; pfam02699
1229492005022	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1229492005023	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1229492005024	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1229492005025	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1229492005026	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1229492005027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492005028	Walker A motif; other site
1229492005029	ATP binding site [chemical binding]; other site
1229492005030	Walker B motif; other site
1229492005031	arginine finger; other site
1229492005032	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1229492005033	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1229492005034	RuvA N terminal domain; Region: RuvA_N; pfam01330
1229492005035	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1229492005036	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
1229492005037	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1229492005038	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1229492005039	GTP1/OBG; Region: GTP1_OBG; pfam01018
1229492005040	Obg GTPase; Region: Obg; cd01898
1229492005041	G1 box; other site
1229492005042	GTP/Mg2+ binding site [chemical binding]; other site
1229492005043	Switch I region; other site
1229492005044	G2 box; other site
1229492005045	G3 box; other site
1229492005046	Switch II region; other site
1229492005047	G4 box; other site
1229492005048	G5 box; other site
1229492005049	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1229492005050	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1229492005051	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
1229492005052	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1229492005053	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1229492005054	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1229492005055	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1229492005056	rod shape-determining protein MreC; Region: MreC; pfam04085
1229492005057	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1229492005058	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492005059	ABC transporter; Region: ABC_tran_2; pfam12848
1229492005060	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229492005061	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492005062	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1229492005063	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229492005064	active site
1229492005065	DNA binding site [nucleotide binding]
1229492005066	Int/Topo IB signature motif; other site
1229492005067	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1229492005068	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1229492005069	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1229492005070	Int/Topo IB signature motif; other site
1229492005071	hypothetical protein; Reviewed; Region: PRK00024
1229492005072	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1229492005073	MPN+ (JAMM) motif; other site
1229492005074	Zinc-binding site [ion binding]; other site
1229492005075	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1229492005076	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1229492005077	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1229492005078	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229492005079	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229492005080	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1229492005081	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229492005082	active site
1229492005083	HIGH motif; other site
1229492005084	nucleotide binding site [chemical binding]; other site
1229492005085	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229492005086	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1229492005087	active site
1229492005088	KMSKS motif; other site
1229492005089	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1229492005090	tRNA binding surface [nucleotide binding]; other site
1229492005091	anticodon binding site; other site
1229492005092	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1229492005093	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1229492005094	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1229492005095	Putative ammonia monooxygenase; Region: AmoA; pfam05145
1229492005096	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1229492005097	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1229492005098	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229492005099	inhibitor-cofactor binding pocket; inhibition site
1229492005100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492005101	catalytic residue [active]
1229492005102	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1229492005103	dimer interface [polypeptide binding]; other site
1229492005104	active site
1229492005105	Schiff base residues; other site
1229492005106	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1229492005107	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1229492005108	active site
1229492005109	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1229492005110	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1229492005111	domain interfaces; other site
1229492005112	active site
1229492005113	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
1229492005114	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1229492005115	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1229492005116	tRNA; other site
1229492005117	putative tRNA binding site [nucleotide binding]; other site
1229492005118	putative NADP binding site [chemical binding]; other site
1229492005119	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1229492005120	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1229492005121	G1 box; other site
1229492005122	GTP/Mg2+ binding site [chemical binding]; other site
1229492005123	Switch I region; other site
1229492005124	G2 box; other site
1229492005125	G3 box; other site
1229492005126	Switch II region; other site
1229492005127	G4 box; other site
1229492005128	G5 box; other site
1229492005129	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1229492005130	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1229492005131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492005132	Walker A motif; other site
1229492005133	ATP binding site [chemical binding]; other site
1229492005134	Walker B motif; other site
1229492005135	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229492005136	trigger factor; Provisional; Region: tig; PRK01490
1229492005137	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1229492005138	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1229492005139	tRNA ribose 2'-O-methyltransferase, aTrm56; Region: Trm56; cl17473
1229492005140	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1229492005141	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1229492005142	23S rRNA binding site [nucleotide binding]; other site
1229492005143	L21 binding site [polypeptide binding]; other site
1229492005144	L13 binding site [polypeptide binding]; other site
1229492005145	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1229492005146	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1229492005147	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1229492005148	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1229492005149	lysine transporter; Provisional; Region: PRK10836
1229492005150	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1229492005151	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1229492005152	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1229492005153	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1229492005154	active site
1229492005155	dimer interface [polypeptide binding]; other site
1229492005156	motif 1; other site
1229492005157	motif 2; other site
1229492005158	motif 3; other site
1229492005159	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1229492005160	anticodon binding site; other site
1229492005161	primosomal protein DnaI; Reviewed; Region: PRK08939
1229492005162	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1229492005163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492005164	Walker A motif; other site
1229492005165	ATP binding site [chemical binding]; other site
1229492005166	Walker B motif; other site
1229492005167	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1229492005168	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1229492005169	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1229492005170	ATP cone domain; Region: ATP-cone; pfam03477
1229492005171	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1229492005172	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1229492005173	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1229492005174	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1229492005175	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1229492005176	CoA-binding site [chemical binding]; other site
1229492005177	ATP-binding [chemical binding]; other site
1229492005178	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1229492005179	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1229492005180	DNA binding site [nucleotide binding]
1229492005181	catalytic residue [active]
1229492005182	H2TH interface [polypeptide binding]; other site
1229492005183	putative catalytic residues [active]
1229492005184	turnover-facilitating residue; other site
1229492005185	intercalation triad [nucleotide binding]; other site
1229492005186	8OG recognition residue [nucleotide binding]; other site
1229492005187	putative reading head residues; other site
1229492005188	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1229492005189	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1229492005190	DNA polymerase I; Provisional; Region: PRK05755
1229492005191	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1229492005192	active site
1229492005193	metal binding site 1 [ion binding]; metal-binding site
1229492005194	putative 5' ssDNA interaction site; other site
1229492005195	metal binding site 3; metal-binding site
1229492005196	metal binding site 2 [ion binding]; metal-binding site
1229492005197	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1229492005198	putative DNA binding site [nucleotide binding]; other site
1229492005199	putative metal binding site [ion binding]; other site
1229492005200	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1229492005201	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1229492005202	active site
1229492005203	DNA binding site [nucleotide binding]
1229492005204	catalytic site [active]
1229492005205	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229492005206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492005207	dimer interface [polypeptide binding]; other site
1229492005208	phosphorylation site [posttranslational modification]
1229492005209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492005210	ATP binding site [chemical binding]; other site
1229492005211	Mg2+ binding site [ion binding]; other site
1229492005212	G-X-G motif; other site
1229492005213	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492005214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492005215	active site
1229492005216	phosphorylation site [posttranslational modification]
1229492005217	intermolecular recognition site; other site
1229492005218	dimerization interface [polypeptide binding]; other site
1229492005219	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492005220	DNA binding site [nucleotide binding]
1229492005221	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1229492005222	isocitrate dehydrogenase; Validated; Region: PRK07362
1229492005223	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1229492005224	dimer interface [polypeptide binding]; other site
1229492005225	Citrate synthase; Region: Citrate_synt; pfam00285
1229492005226	active site
1229492005227	citrylCoA binding site [chemical binding]; other site
1229492005228	oxalacetate/citrate binding site [chemical binding]; other site
1229492005229	coenzyme A binding site [chemical binding]; other site
1229492005230	catalytic triad [active]
1229492005231	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229492005232	pyruvate kinase; Provisional; Region: PRK06354
1229492005233	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1229492005234	domain interfaces; other site
1229492005235	active site
1229492005236	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1229492005237	6-phosphofructokinase; Provisional; Region: PRK03202
1229492005238	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1229492005239	active site
1229492005240	ADP/pyrophosphate binding site [chemical binding]; other site
1229492005241	dimerization interface [polypeptide binding]; other site
1229492005242	allosteric effector site; other site
1229492005243	fructose-1,6-bisphosphate binding site; other site
1229492005244	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1229492005245	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1229492005246	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1229492005247	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1229492005248	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1229492005249	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1229492005250	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1229492005251	putative NAD(P) binding site [chemical binding]; other site
1229492005252	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1229492005253	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1229492005254	active site
1229492005255	PHP Thumb interface [polypeptide binding]; other site
1229492005256	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1229492005257	generic binding surface I; other site
1229492005258	generic binding surface II; other site
1229492005259	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1229492005260	DHH family; Region: DHH; pfam01368
1229492005261	DHHA1 domain; Region: DHHA1; pfam02272
1229492005262	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1229492005263	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1229492005264	DNA-binding site [nucleotide binding]; DNA binding site
1229492005265	DRTGG domain; Region: DRTGG; pfam07085
1229492005266	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1229492005267	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1229492005268	active site 2 [active]
1229492005269	active site 1 [active]
1229492005270	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229492005271	Ligand Binding Site [chemical binding]; other site
1229492005272	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1229492005273	metal-dependent hydrolase; Provisional; Region: PRK00685
1229492005274	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229492005275	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229492005276	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1229492005277	active site
1229492005278	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1229492005279	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1229492005280	hexamer interface [polypeptide binding]; other site
1229492005281	ligand binding site [chemical binding]; other site
1229492005282	putative active site [active]
1229492005283	NAD(P) binding site [chemical binding]; other site
1229492005284	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229492005285	Ligand Binding Site [chemical binding]; other site
1229492005286	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1229492005287	propionate/acetate kinase; Provisional; Region: PRK12379
1229492005288	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1229492005289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492005290	S-adenosylmethionine binding site [chemical binding]; other site
1229492005291	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1229492005292	dimer interface [polypeptide binding]; other site
1229492005293	catalytic triad [active]
1229492005294	peroxidatic and resolving cysteines [active]
1229492005295	hypothetical protein; Provisional; Region: PRK10621
1229492005296	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1229492005297	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1229492005298	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1229492005299	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1229492005300	Ligand Binding Site [chemical binding]; other site
1229492005301	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1229492005302	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1229492005303	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492005304	catalytic residue [active]
1229492005305	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1229492005306	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1229492005307	GAF domain; Region: GAF_2; pfam13185
1229492005308	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1229492005309	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1229492005310	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492005311	RNA binding surface [nucleotide binding]; other site
1229492005312	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229492005313	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1229492005314	active site
1229492005315	catalytic site [active]
1229492005316	OsmC-like protein; Region: OsmC; cl00767
1229492005317	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1229492005318	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492005319	catalytic residue [active]
1229492005320	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1229492005321	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1229492005322	ligand binding site [chemical binding]; other site
1229492005323	NAD binding site [chemical binding]; other site
1229492005324	dimerization interface [polypeptide binding]; other site
1229492005325	catalytic site [active]
1229492005326	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1229492005327	putative L-serine binding site [chemical binding]; other site
1229492005328	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1229492005329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492005330	motif II; other site
1229492005331	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1229492005332	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492005333	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492005334	active site turn [active]
1229492005335	phosphorylation site [posttranslational modification]
1229492005336	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1229492005337	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1229492005338	putative acyl-acceptor binding pocket; other site
1229492005339	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229492005340	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229492005341	protein binding site [polypeptide binding]; other site
1229492005342	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1229492005343	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1229492005344	active site
1229492005345	HIGH motif; other site
1229492005346	dimer interface [polypeptide binding]; other site
1229492005347	KMSKS motif; other site
1229492005348	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492005349	RNA binding surface [nucleotide binding]; other site
1229492005350	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1229492005351	Transglycosylase; Region: Transgly; pfam00912
1229492005352	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
1229492005353	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1229492005354	NEAr Transporter domain; Region: NEAT; smart00725
1229492005355	NEAr Transporter domain; Region: NEAT; smart00725
1229492005356	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1229492005357	heme-binding site [chemical binding]; other site
1229492005358	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1229492005359	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1229492005360	Potassium binding sites [ion binding]; other site
1229492005361	Cesium cation binding sites [ion binding]; other site
1229492005362	acetyl-CoA synthetase; Provisional; Region: PRK04319
1229492005363	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1229492005364	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1229492005365	active site
1229492005366	acyl-activating enzyme (AAE) consensus motif; other site
1229492005367	putative CoA binding site [chemical binding]; other site
1229492005368	AMP binding site [chemical binding]; other site
1229492005369	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1229492005370	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1229492005371	active site
1229492005372	Zn binding site [ion binding]; other site
1229492005373	catabolite control protein A; Region: ccpA; TIGR01481
1229492005374	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229492005375	DNA binding site [nucleotide binding]
1229492005376	domain linker motif; other site
1229492005377	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1229492005378	dimerization interface [polypeptide binding]; other site
1229492005379	effector binding site; other site
1229492005380	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1229492005381	Chorismate mutase type II; Region: CM_2; cl00693
1229492005382	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1229492005383	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1229492005384	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1229492005385	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229492005386	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229492005387	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229492005388	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1229492005389	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229492005390	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1229492005391	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1229492005392	putative tRNA-binding site [nucleotide binding]; other site
1229492005393	hypothetical protein; Provisional; Region: PRK13668
1229492005394	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229492005395	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229492005396	catalytic residues [active]
1229492005397	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1229492005398	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1229492005399	oligomer interface [polypeptide binding]; other site
1229492005400	active site
1229492005401	metal binding site [ion binding]; metal-binding site
1229492005402	Predicted small secreted protein [Function unknown]; Region: COG5584
1229492005403	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1229492005404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492005405	S-adenosylmethionine binding site [chemical binding]; other site
1229492005406	Phosphotransferase enzyme family; Region: APH; pfam01636
1229492005407	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1229492005408	active site
1229492005409	substrate binding site [chemical binding]; other site
1229492005410	ATP binding site [chemical binding]; other site
1229492005411	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1229492005412	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1229492005413	homodimer interface [polypeptide binding]; other site
1229492005414	substrate-cofactor binding pocket; other site
1229492005415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492005416	catalytic residue [active]
1229492005417	dipeptidase PepV; Reviewed; Region: PRK07318
1229492005418	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1229492005419	active site
1229492005420	metal binding site [ion binding]; metal-binding site
1229492005421	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1229492005422	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229492005423	RNA binding surface [nucleotide binding]; other site
1229492005424	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1229492005425	active site
1229492005426	uracil binding [chemical binding]; other site
1229492005427	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229492005428	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1229492005429	HI0933-like protein; Region: HI0933_like; pfam03486
1229492005430	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229492005431	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492005432	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1229492005433	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005434	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005435	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005436	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005437	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005438	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005439	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005440	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005441	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005442	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005443	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005444	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005445	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005446	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492005447	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1229492005448	active site residue [active]
1229492005449	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1229492005450	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1229492005451	HIGH motif; other site
1229492005452	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229492005453	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1229492005454	active site
1229492005455	KMSKS motif; other site
1229492005456	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1229492005457	tRNA binding surface [nucleotide binding]; other site
1229492005458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492005459	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492005460	putative substrate translocation pore; other site
1229492005461	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1229492005462	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229492005463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492005464	S-adenosylmethionine binding site [chemical binding]; other site
1229492005465	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492005466	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1229492005467	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229492005468	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1229492005469	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1229492005470	homopentamer interface [polypeptide binding]; other site
1229492005471	active site
1229492005472	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1229492005473	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1229492005474	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1229492005475	dimerization interface [polypeptide binding]; other site
1229492005476	active site
1229492005477	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1229492005478	Lumazine binding domain; Region: Lum_binding; pfam00677
1229492005479	Lumazine binding domain; Region: Lum_binding; pfam00677
1229492005480	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1229492005481	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1229492005482	catalytic motif [active]
1229492005483	Zn binding site [ion binding]; other site
1229492005484	RibD C-terminal domain; Region: RibD_C; cl17279
1229492005485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1229492005486	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1229492005487	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229492005488	dimerization interface [polypeptide binding]; other site
1229492005489	putative DNA binding site [nucleotide binding]; other site
1229492005490	putative Zn2+ binding site [ion binding]; other site
1229492005491	arsenical pump membrane protein; Provisional; Region: PRK15445
1229492005492	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1229492005493	transmembrane helices; other site
1229492005494	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1229492005495	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1229492005496	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1229492005497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1229492005498	DNA binding residues [nucleotide binding]
1229492005499	CAAX protease self-immunity; Region: Abi; pfam02517
1229492005500	CAAX protease self-immunity; Region: Abi; pfam02517
1229492005501	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1229492005502	active site
1229492005503	intersubunit interactions; other site
1229492005504	catalytic residue [active]
1229492005505	camphor resistance protein CrcB; Provisional; Region: PRK14201
1229492005506	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1229492005507	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229492005508	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229492005509	active site
1229492005510	catalytic tetrad [active]
1229492005511	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1229492005512	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1229492005513	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1229492005514	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1229492005515	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1229492005516	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1229492005517	active site
1229492005518	substrate-binding site [chemical binding]; other site
1229492005519	metal-binding site [ion binding]
1229492005520	ATP binding site [chemical binding]; other site
1229492005521	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1229492005522	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229492005523	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1229492005524	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1229492005525	nudix motif; other site
1229492005526	Haemolytic domain; Region: Haemolytic; pfam01809
1229492005527	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1229492005528	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1229492005529	metal binding site [ion binding]; metal-binding site
1229492005530	substrate binding pocket [chemical binding]; other site
1229492005531	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229492005532	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1229492005533	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1229492005534	acyl-activating enzyme (AAE) consensus motif; other site
1229492005535	putative AMP binding site [chemical binding]; other site
1229492005536	putative active site [active]
1229492005537	putative CoA binding site [chemical binding]; other site
1229492005538	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1229492005539	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1229492005540	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
1229492005541	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1229492005542	HTH-like domain; Region: HTH_21; pfam13276
1229492005543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229492005544	Transposase; Region: HTH_Tnp_1; pfam01527
1229492005545	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492005546	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492005547	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492005548	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1229492005549	substrate binding site [chemical binding]; other site
1229492005550	catalytic residues [active]
1229492005551	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492005552	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492005553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492005554	Walker A motif; other site
1229492005555	ATP binding site [chemical binding]; other site
1229492005556	Walker B motif; other site
1229492005557	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229492005558	Integrase core domain; Region: rve; pfam00665
1229492005559	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1229492005560	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1229492005561	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1229492005562	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229492005563	ferrochelatase; Provisional; Region: PRK12435
1229492005564	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1229492005565	C-terminal domain interface [polypeptide binding]; other site
1229492005566	active site
1229492005567	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1229492005568	active site
1229492005569	N-terminal domain interface [polypeptide binding]; other site
1229492005570	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1229492005571	substrate binding site [chemical binding]; other site
1229492005572	active site
1229492005573	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1229492005574	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1229492005575	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1229492005576	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229492005577	Walker A/P-loop; other site
1229492005578	ATP binding site [chemical binding]; other site
1229492005579	Q-loop/lid; other site
1229492005580	ABC transporter signature motif; other site
1229492005581	Walker B; other site
1229492005582	D-loop; other site
1229492005583	H-loop/switch region; other site
1229492005584	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1229492005585	HIT family signature motif; other site
1229492005586	catalytic residue [active]
1229492005587	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1229492005588	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1229492005589	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1229492005590	SurA N-terminal domain; Region: SurA_N_3; cl07813
1229492005591	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1229492005592	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1229492005593	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1229492005594	generic binding surface II; other site
1229492005595	generic binding surface I; other site
1229492005596	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229492005597	Zn2+ binding site [ion binding]; other site
1229492005598	Mg2+ binding site [ion binding]; other site
1229492005599	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1229492005600	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1229492005601	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
1229492005602	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1229492005603	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1229492005604	active site
1229492005605	metal binding site [ion binding]; metal-binding site
1229492005606	DNA binding site [nucleotide binding]
1229492005607	hypothetical protein; Provisional; Region: PRK13676
1229492005608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1229492005609	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229492005610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492005611	non-specific DNA binding site [nucleotide binding]; other site
1229492005612	salt bridge; other site
1229492005613	sequence-specific DNA binding site [nucleotide binding]; other site
1229492005614	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229492005615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492005616	active site
1229492005617	phosphorylation site [posttranslational modification]
1229492005618	intermolecular recognition site; other site
1229492005619	dimerization interface [polypeptide binding]; other site
1229492005620	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229492005621	DNA binding residues [nucleotide binding]
1229492005622	dimerization interface [polypeptide binding]; other site
1229492005623	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1229492005624	GAF domain; Region: GAF_3; pfam13492
1229492005625	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229492005626	Histidine kinase; Region: HisKA_3; pfam07730
1229492005627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492005628	ATP binding site [chemical binding]; other site
1229492005629	Mg2+ binding site [ion binding]; other site
1229492005630	G-X-G motif; other site
1229492005631	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229492005632	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229492005633	active site
1229492005634	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1229492005635	Class II fumarases; Region: Fumarase_classII; cd01362
1229492005636	active site
1229492005637	tetramer interface [polypeptide binding]; other site
1229492005638	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1229492005639	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1229492005640	active site
1229492005641	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1229492005642	epoxyqueuosine reductase; Region: TIGR00276
1229492005643	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1229492005644	HEAT repeats; Region: HEAT_2; pfam13646
1229492005645	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229492005646	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229492005647	Walker A/P-loop; other site
1229492005648	ATP binding site [chemical binding]; other site
1229492005649	Q-loop/lid; other site
1229492005650	ABC transporter signature motif; other site
1229492005651	Walker B; other site
1229492005652	D-loop; other site
1229492005653	H-loop/switch region; other site
1229492005654	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229492005655	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229492005656	substrate binding pocket [chemical binding]; other site
1229492005657	membrane-bound complex binding site; other site
1229492005658	hinge residues; other site
1229492005659	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229492005660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492005661	dimer interface [polypeptide binding]; other site
1229492005662	conserved gate region; other site
1229492005663	putative PBP binding loops; other site
1229492005664	ABC-ATPase subunit interface; other site
1229492005665	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1229492005666	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229492005667	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1229492005668	metal binding site 2 [ion binding]; metal-binding site
1229492005669	putative DNA binding helix; other site
1229492005670	metal binding site 1 [ion binding]; metal-binding site
1229492005671	dimer interface [polypeptide binding]; other site
1229492005672	structural Zn2+ binding site [ion binding]; other site
1229492005673	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1229492005674	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229492005675	putative ligand binding site [chemical binding]; other site
1229492005676	NAD binding site [chemical binding]; other site
1229492005677	catalytic site [active]
1229492005678	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1229492005679	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1229492005680	catalytic triad [active]
1229492005681	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1229492005682	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229492005683	inhibitor-cofactor binding pocket; inhibition site
1229492005684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492005685	catalytic residue [active]
1229492005686	Predicted membrane protein [Function unknown]; Region: COG4129
1229492005687	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1229492005688	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229492005689	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229492005690	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1229492005691	Walker A/P-loop; other site
1229492005692	ATP binding site [chemical binding]; other site
1229492005693	Q-loop/lid; other site
1229492005694	ABC transporter signature motif; other site
1229492005695	Walker B; other site
1229492005696	D-loop; other site
1229492005697	H-loop/switch region; other site
1229492005698	hypothetical protein; Provisional; Region: PRK13662
1229492005699	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1229492005700	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229492005701	minor groove reading motif; other site
1229492005702	helix-hairpin-helix signature motif; other site
1229492005703	substrate binding pocket [chemical binding]; other site
1229492005704	active site
1229492005705	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1229492005706	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1229492005707	DNA binding and oxoG recognition site [nucleotide binding]
1229492005708	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1229492005709	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1229492005710	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1229492005711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492005712	Walker A/P-loop; other site
1229492005713	ATP binding site [chemical binding]; other site
1229492005714	Q-loop/lid; other site
1229492005715	ABC transporter signature motif; other site
1229492005716	Walker B; other site
1229492005717	H-loop/switch region; other site
1229492005718	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1229492005719	recombination regulator RecX; Provisional; Region: recX; PRK14135
1229492005720	glycosyltransferase; Provisional; Region: PRK13481
1229492005721	Transglycosylase; Region: Transgly; pfam00912
1229492005722	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1229492005723	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1229492005724	proposed catalytic triad [active]
1229492005725	conserved cys residue [active]
1229492005726	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1229492005727	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492005728	FeS/SAM binding site; other site
1229492005729	YfkB-like domain; Region: YfkB; pfam08756
1229492005730	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1229492005731	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1229492005732	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1229492005733	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
1229492005734	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229492005735	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229492005736	active site
1229492005737	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1229492005738	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229492005739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492005740	active site
1229492005741	phosphorylation site [posttranslational modification]
1229492005742	intermolecular recognition site; other site
1229492005743	dimerization interface [polypeptide binding]; other site
1229492005744	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229492005745	DNA binding residues [nucleotide binding]
1229492005746	dimerization interface [polypeptide binding]; other site
1229492005747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229492005748	Histidine kinase; Region: HisKA_3; pfam07730
1229492005749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492005750	ATP binding site [chemical binding]; other site
1229492005751	Mg2+ binding site [ion binding]; other site
1229492005752	G-X-G motif; other site
1229492005753	Predicted membrane protein [Function unknown]; Region: COG4758
1229492005754	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1229492005755	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1229492005756	active site
1229492005757	Predicted membrane protein [Function unknown]; Region: COG4129
1229492005758	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1229492005759	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1229492005760	catalytic triad [active]
1229492005761	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1229492005762	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229492005763	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1229492005764	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1229492005765	Ferritin-like domain; Region: Ferritin; pfam00210
1229492005766	ferroxidase diiron center [ion binding]; other site
1229492005767	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1229492005768	active site
1229492005769	catalytic site [active]
1229492005770	substrate binding site [chemical binding]; other site
1229492005771	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1229492005772	active site
1229492005773	DNA polymerase IV; Validated; Region: PRK02406
1229492005774	DNA binding site [nucleotide binding]
1229492005775	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1229492005776	TRAM domain; Region: TRAM; cl01282
1229492005777	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1229492005778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492005779	S-adenosylmethionine binding site [chemical binding]; other site
1229492005780	putative lipid kinase; Reviewed; Region: PRK13337
1229492005781	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1229492005782	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1229492005783	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1229492005784	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1229492005785	GatB domain; Region: GatB_Yqey; pfam02637
1229492005786	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1229492005787	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1229492005788	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1229492005789	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1229492005790	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1229492005791	Na binding site [ion binding]; other site
1229492005792	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1229492005793	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1229492005794	putative dimer interface [polypeptide binding]; other site
1229492005795	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1229492005796	putative dimer interface [polypeptide binding]; other site
1229492005797	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1229492005798	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1229492005799	nucleotide binding pocket [chemical binding]; other site
1229492005800	K-X-D-G motif; other site
1229492005801	catalytic site [active]
1229492005802	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1229492005803	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1229492005804	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1229492005805	Dimer interface [polypeptide binding]; other site
1229492005806	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1229492005807	Part of AAA domain; Region: AAA_19; pfam13245
1229492005808	Family description; Region: UvrD_C_2; pfam13538
1229492005809	PcrB family; Region: PcrB; pfam01884
1229492005810	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1229492005811	substrate binding site [chemical binding]; other site
1229492005812	putative active site [active]
1229492005813	dimer interface [polypeptide binding]; other site
1229492005814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
1229492005815	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1229492005816	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1229492005817	tetramer interface [polypeptide binding]; other site
1229492005818	active site
1229492005819	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1229492005820	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1229492005821	Staphostatin A; Region: Staphostatin_A; pfam09022
1229492005822	NETI protein; Region: NETI; pfam14044
1229492005823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1229492005824	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1229492005825	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1229492005826	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1229492005827	homodimer interface [polypeptide binding]; other site
1229492005828	NAD binding pocket [chemical binding]; other site
1229492005829	ATP binding pocket [chemical binding]; other site
1229492005830	Mg binding site [ion binding]; other site
1229492005831	active-site loop [active]
1229492005832	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1229492005833	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1229492005834	active site
1229492005835	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1229492005836	active site
1229492005837	dimer interface [polypeptide binding]; other site
1229492005838	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1229492005839	Prephenate dehydratase; Region: PDT; pfam00800
1229492005840	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1229492005841	putative L-Phe binding site [chemical binding]; other site
1229492005842	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1229492005843	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1229492005844	transmembrane helices; other site
1229492005845	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1229492005846	Isochorismatase family; Region: Isochorismatase; pfam00857
1229492005847	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229492005848	catalytic triad [active]
1229492005849	conserved cis-peptide bond; other site
1229492005850	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1229492005851	DHH family; Region: DHH; pfam01368
1229492005852	DHHA2 domain; Region: DHHA2; pfam02833
1229492005853	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1229492005854	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1229492005855	NAD(P) binding site [chemical binding]; other site
1229492005856	catalytic residues [active]
1229492005857	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1229492005858	Predicted transcriptional regulator [Transcription]; Region: COG3682
1229492005859	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1229492005860	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1229492005861	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1229492005862	YolD-like protein; Region: YolD; pfam08863
1229492005863	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1229492005864	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
1229492005865	Int/Topo IB signature motif; other site
1229492005866	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1229492005867	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1229492005868	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1229492005869	Int/Topo IB signature motif; other site
1229492005870	YolD-like protein; Region: YolD; pfam08863
1229492005871	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1229492005872	active site
1229492005873	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1229492005874	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1229492005875	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1229492005876	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1229492005877	Bacterial PH domain; Region: DUF304; cl01348
1229492005878	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
1229492005879	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229492005880	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229492005881	Walker A/P-loop; other site
1229492005882	ATP binding site [chemical binding]; other site
1229492005883	Q-loop/lid; other site
1229492005884	ABC transporter signature motif; other site
1229492005885	Walker B; other site
1229492005886	D-loop; other site
1229492005887	H-loop/switch region; other site
1229492005888	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1229492005889	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229492005890	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229492005891	Walker A/P-loop; other site
1229492005892	ATP binding site [chemical binding]; other site
1229492005893	Q-loop/lid; other site
1229492005894	ABC transporter signature motif; other site
1229492005895	Walker B; other site
1229492005896	D-loop; other site
1229492005897	H-loop/switch region; other site
1229492005898	Predicted transcriptional regulators [Transcription]; Region: COG1725
1229492005899	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229492005900	DNA-binding site [nucleotide binding]; DNA binding site
1229492005901	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1229492005902	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229492005903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492005904	homodimer interface [polypeptide binding]; other site
1229492005905	catalytic residue [active]
1229492005906	MAP domain; Region: MAP; pfam03642
1229492005907	MAP domain; Region: MAP; pfam03642
1229492005908	MAP domain; Region: MAP; pfam03642
1229492005909	MAP domain; Region: MAP; pfam03642
1229492005910	MAP domain; Region: MAP; pfam03642
1229492005911	MAP domain; Region: MAP; pfam03642
1229492005912	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1229492005913	putative catalytic site [active]
1229492005914	metal binding site A [ion binding]; metal-binding site
1229492005915	phosphate binding site [ion binding]; other site
1229492005916	metal binding site C [ion binding]; metal-binding site
1229492005917	metal binding site B [ion binding]; metal-binding site
1229492005918	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1229492005919	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1229492005920	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1229492005921	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1229492005922	metal binding site [ion binding]; metal-binding site
1229492005923	dimer interface [polypeptide binding]; other site
1229492005924	Cation transport protein; Region: TrkH; cl17365
1229492005925	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1229492005926	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1229492005927	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1229492005928	ring oligomerisation interface [polypeptide binding]; other site
1229492005929	ATP/Mg binding site [chemical binding]; other site
1229492005930	stacking interactions; other site
1229492005931	hinge regions; other site
1229492005932	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1229492005933	oligomerisation interface [polypeptide binding]; other site
1229492005934	mobile loop; other site
1229492005935	roof hairpin; other site
1229492005936	CAAX protease self-immunity; Region: Abi; pfam02517
1229492005937	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1229492005938	dimer interface [polypeptide binding]; other site
1229492005939	FMN binding site [chemical binding]; other site
1229492005940	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1229492005941	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1229492005942	putative active site [active]
1229492005943	catalytic triad [active]
1229492005944	putative dimer interface [polypeptide binding]; other site
1229492005945	delta-hemolysin; Provisional; Region: PRK14752
1229492005946	Accessory gene regulator B; Region: AgrB; smart00793
1229492005947	Staphylococcal AgrD protein; Region: AgrD; smart00794
1229492005948	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1229492005949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492005950	Mg2+ binding site [ion binding]; other site
1229492005951	G-X-G motif; other site
1229492005952	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1229492005953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492005954	active site
1229492005955	phosphorylation site [posttranslational modification]
1229492005956	intermolecular recognition site; other site
1229492005957	dimerization interface [polypeptide binding]; other site
1229492005958	LytTr DNA-binding domain; Region: LytTR; pfam04397
1229492005959	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229492005960	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1229492005961	putative substrate binding site [chemical binding]; other site
1229492005962	putative ATP binding site [chemical binding]; other site
1229492005963	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1229492005964	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1229492005965	substrate binding [chemical binding]; other site
1229492005966	active site
1229492005967	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1229492005968	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229492005969	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229492005970	DNA binding site [nucleotide binding]
1229492005971	domain linker motif; other site
1229492005972	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1229492005973	dimerization interface [polypeptide binding]; other site
1229492005974	ligand binding site [chemical binding]; other site
1229492005975	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1229492005976	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1229492005977	CPxP  motif; other site
1229492005978	Predicted transporter component [General function prediction only]; Region: COG2391
1229492005979	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
1229492005980	Sulphur transport; Region: Sulf_transp; pfam04143
1229492005981	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1229492005982	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1229492005983	CoA binding domain; Region: CoA_binding; pfam02629
1229492005984	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1229492005985	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492005986	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492005987	ABC transporter; Region: ABC_tran_2; pfam12848
1229492005988	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229492005989	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1229492005990	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492005991	Walker A/P-loop; other site
1229492005992	ATP binding site [chemical binding]; other site
1229492005993	Q-loop/lid; other site
1229492005994	ABC transporter signature motif; other site
1229492005995	Walker B; other site
1229492005996	D-loop; other site
1229492005997	H-loop/switch region; other site
1229492005998	UGMP family protein; Validated; Region: PRK09604
1229492005999	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1229492006000	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1229492006001	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492006002	Coenzyme A binding pocket [chemical binding]; other site
1229492006003	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1229492006004	Glycoprotease family; Region: Peptidase_M22; pfam00814
1229492006005	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1229492006006	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1229492006007	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1229492006008	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1229492006009	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229492006010	PYR/PP interface [polypeptide binding]; other site
1229492006011	dimer interface [polypeptide binding]; other site
1229492006012	TPP binding site [chemical binding]; other site
1229492006013	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229492006014	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1229492006015	TPP-binding site [chemical binding]; other site
1229492006016	dimer interface [polypeptide binding]; other site
1229492006017	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
1229492006018	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1229492006019	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1229492006020	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1229492006021	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1229492006022	2-isopropylmalate synthase; Validated; Region: PRK00915
1229492006023	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1229492006024	active site
1229492006025	catalytic residues [active]
1229492006026	metal binding site [ion binding]; metal-binding site
1229492006027	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1229492006028	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1229492006029	tartrate dehydrogenase; Region: TTC; TIGR02089
1229492006030	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1229492006031	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1229492006032	substrate binding site [chemical binding]; other site
1229492006033	ligand binding site [chemical binding]; other site
1229492006034	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1229492006035	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1229492006036	substrate binding site [chemical binding]; other site
1229492006037	threonine dehydratase; Validated; Region: PRK08639
1229492006038	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229492006039	tetramer interface [polypeptide binding]; other site
1229492006040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492006041	catalytic residue [active]
1229492006042	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1229492006043	putative Ile/Val binding site [chemical binding]; other site
1229492006044	hypothetical protein; Provisional; Region: PRK04351
1229492006045	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1229492006046	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1229492006047	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1229492006048	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1229492006049	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1229492006050	RNA binding site [nucleotide binding]; other site
1229492006051	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
1229492006052	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229492006053	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229492006054	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229492006055	DNA binding residues [nucleotide binding]
1229492006056	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1229492006057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492006058	ATP binding site [chemical binding]; other site
1229492006059	Mg2+ binding site [ion binding]; other site
1229492006060	G-X-G motif; other site
1229492006061	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1229492006062	anti sigma factor interaction site; other site
1229492006063	regulatory phosphorylation site [posttranslational modification]; other site
1229492006064	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1229492006065	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1229492006066	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1229492006067	PemK-like protein; Region: PemK; pfam02452
1229492006068	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1229492006069	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1229492006070	active site
1229492006071	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229492006072	dimer interface [polypeptide binding]; other site
1229492006073	substrate binding site [chemical binding]; other site
1229492006074	catalytic residues [active]
1229492006075	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1229492006076	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1229492006077	Predicted membrane protein [Function unknown]; Region: COG3428
1229492006078	Bacterial PH domain; Region: DUF304; pfam03703
1229492006079	Bacterial PH domain; Region: DUF304; pfam03703
1229492006080	Bacterial PH domain; Region: DUF304; cl01348
1229492006081	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1229492006082	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
1229492006083	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229492006084	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1229492006085	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
1229492006086	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1229492006087	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1229492006088	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1229492006089	Ligand Binding Site [chemical binding]; other site
1229492006090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492006091	dimer interface [polypeptide binding]; other site
1229492006092	phosphorylation site [posttranslational modification]
1229492006093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492006094	ATP binding site [chemical binding]; other site
1229492006095	Mg2+ binding site [ion binding]; other site
1229492006096	G-X-G motif; other site
1229492006097	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492006098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492006099	active site
1229492006100	phosphorylation site [posttranslational modification]
1229492006101	intermolecular recognition site; other site
1229492006102	dimerization interface [polypeptide binding]; other site
1229492006103	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492006104	DNA binding site [nucleotide binding]
1229492006105	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1229492006106	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229492006107	ATP binding site [chemical binding]; other site
1229492006108	Mg++ binding site [ion binding]; other site
1229492006109	motif III; other site
1229492006110	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229492006111	nucleotide binding region [chemical binding]; other site
1229492006112	ATP-binding site [chemical binding]; other site
1229492006113	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1229492006114	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229492006115	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229492006116	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229492006117	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1229492006118	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1229492006119	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1229492006120	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1229492006121	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1229492006122	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
1229492006123	putative homodimer interface [polypeptide binding]; other site
1229492006124	putative homotetramer interface [polypeptide binding]; other site
1229492006125	allosteric switch controlling residues; other site
1229492006126	putative metal binding site [ion binding]; other site
1229492006127	putative homodimer-homodimer interface [polypeptide binding]; other site
1229492006128	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1229492006129	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1229492006130	putative active site [active]
1229492006131	catalytic site [active]
1229492006132	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1229492006133	putative active site [active]
1229492006134	catalytic site [active]
1229492006135	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1229492006136	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229492006137	Zn2+ binding site [ion binding]; other site
1229492006138	Mg2+ binding site [ion binding]; other site
1229492006139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1229492006140	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1229492006141	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1229492006142	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1229492006143	thiamine phosphate binding site [chemical binding]; other site
1229492006144	active site
1229492006145	pyrophosphate binding site [ion binding]; other site
1229492006146	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1229492006147	substrate binding site [chemical binding]; other site
1229492006148	multimerization interface [polypeptide binding]; other site
1229492006149	ATP binding site [chemical binding]; other site
1229492006150	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229492006151	dimer interface [polypeptide binding]; other site
1229492006152	substrate binding site [chemical binding]; other site
1229492006153	ATP binding site [chemical binding]; other site
1229492006154	thiaminase II; Region: salvage_TenA; TIGR04306
1229492006155	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1229492006156	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1229492006157	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1229492006158	dimer interface [polypeptide binding]; other site
1229492006159	ssDNA binding site [nucleotide binding]; other site
1229492006160	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229492006161	YwpF-like protein; Region: YwpF; pfam14183
1229492006162	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1229492006163	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1229492006164	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1229492006165	hinge; other site
1229492006166	active site
1229492006167	Predicted membrane protein [Function unknown]; Region: COG4836
1229492006168	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
1229492006169	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1229492006170	gamma subunit interface [polypeptide binding]; other site
1229492006171	epsilon subunit interface [polypeptide binding]; other site
1229492006172	LBP interface [polypeptide binding]; other site
1229492006173	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1229492006174	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229492006175	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1229492006176	alpha subunit interaction interface [polypeptide binding]; other site
1229492006177	Walker A motif; other site
1229492006178	ATP binding site [chemical binding]; other site
1229492006179	Walker B motif; other site
1229492006180	inhibitor binding site; inhibition site
1229492006181	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1229492006182	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1229492006183	core domain interface [polypeptide binding]; other site
1229492006184	delta subunit interface [polypeptide binding]; other site
1229492006185	epsilon subunit interface [polypeptide binding]; other site
1229492006186	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1229492006187	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229492006188	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1229492006189	beta subunit interaction interface [polypeptide binding]; other site
1229492006190	Walker A motif; other site
1229492006191	ATP binding site [chemical binding]; other site
1229492006192	Walker B motif; other site
1229492006193	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1229492006194	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1229492006195	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1229492006196	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
1229492006197	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1229492006198	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1229492006199	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1229492006200	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1229492006201	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1229492006202	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1229492006203	active site
1229492006204	homodimer interface [polypeptide binding]; other site
1229492006205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229492006206	active site
1229492006207	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1229492006208	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1229492006209	dimer interface [polypeptide binding]; other site
1229492006210	active site
1229492006211	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1229492006212	folate binding site [chemical binding]; other site
1229492006213	hypothetical protein; Provisional; Region: PRK13690
1229492006214	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229492006215	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229492006216	active site
1229492006217	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1229492006218	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1229492006219	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1229492006220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492006221	S-adenosylmethionine binding site [chemical binding]; other site
1229492006222	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1229492006223	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1229492006224	RF-1 domain; Region: RF-1; pfam00472
1229492006225	thymidine kinase; Provisional; Region: PRK04296
1229492006226	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1229492006227	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1229492006228	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1229492006229	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1229492006230	RNA binding site [nucleotide binding]; other site
1229492006231	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1229492006232	multimer interface [polypeptide binding]; other site
1229492006233	Walker A motif; other site
1229492006234	ATP binding site [chemical binding]; other site
1229492006235	Walker B motif; other site
1229492006236	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1229492006237	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229492006238	NAD binding site [chemical binding]; other site
1229492006239	catalytic residues [active]
1229492006240	Predicted transcriptional regulators [Transcription]; Region: COG1733
1229492006241	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1229492006242	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1229492006243	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1229492006244	hinge; other site
1229492006245	active site
1229492006246	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1229492006247	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1229492006248	intersubunit interface [polypeptide binding]; other site
1229492006249	active site
1229492006250	zinc binding site [ion binding]; other site
1229492006251	Na+ binding site [ion binding]; other site
1229492006252	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1229492006253	CTP synthetase; Validated; Region: pyrG; PRK05380
1229492006254	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1229492006255	Catalytic site [active]
1229492006256	active site
1229492006257	UTP binding site [chemical binding]; other site
1229492006258	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1229492006259	active site
1229492006260	putative oxyanion hole; other site
1229492006261	catalytic triad [active]
1229492006262	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1229492006263	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1229492006264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492006265	Coenzyme A binding pocket [chemical binding]; other site
1229492006266	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229492006267	Coenzyme A binding pocket [chemical binding]; other site
1229492006268	pantothenate kinase; Provisional; Region: PRK13317
1229492006269	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1229492006270	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1229492006271	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1229492006272	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229492006273	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1229492006274	metal binding site [ion binding]; metal-binding site
1229492006275	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1229492006276	Predicted membrane protein [Function unknown]; Region: COG4270
1229492006277	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1229492006278	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1229492006279	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1229492006280	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1229492006281	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1229492006282	intersubunit interface [polypeptide binding]; other site
1229492006283	active site
1229492006284	catalytic residue [active]
1229492006285	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1229492006286	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1229492006287	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1229492006288	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1229492006289	dimerization interface [polypeptide binding]; other site
1229492006290	DPS ferroxidase diiron center [ion binding]; other site
1229492006291	ion pore; other site
1229492006292	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1229492006293	EVE domain; Region: EVE; cl00728
1229492006294	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1229492006295	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1229492006296	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1229492006297	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1229492006298	NAD(P) binding site [chemical binding]; other site
1229492006299	putative active site [active]
1229492006300	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229492006301	dimerization interface [polypeptide binding]; other site
1229492006302	putative DNA binding site [nucleotide binding]; other site
1229492006303	putative Zn2+ binding site [ion binding]; other site
1229492006304	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1229492006305	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1229492006306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229492006307	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1229492006308	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492006309	active site
1229492006310	motif I; other site
1229492006311	motif II; other site
1229492006312	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492006313	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1229492006314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492006315	Walker A/P-loop; other site
1229492006316	ATP binding site [chemical binding]; other site
1229492006317	Q-loop/lid; other site
1229492006318	ABC transporter signature motif; other site
1229492006319	Walker B; other site
1229492006320	D-loop; other site
1229492006321	H-loop/switch region; other site
1229492006322	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
1229492006323	TIR domain; Region: TIR_2; pfam13676
1229492006324	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1229492006325	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1229492006326	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229492006327	AAA domain; Region: AAA_22; pfam13401
1229492006328	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1229492006329	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1229492006330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229492006331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229492006332	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1229492006333	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229492006334	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1229492006335	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1229492006336	glutaminase active site [active]
1229492006337	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1229492006338	dimer interface [polypeptide binding]; other site
1229492006339	active site
1229492006340	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1229492006341	dimer interface [polypeptide binding]; other site
1229492006342	active site
1229492006343	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1229492006344	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1229492006345	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1229492006346	active site
1229492006347	P-loop; other site
1229492006348	phosphorylation site [posttranslational modification]
1229492006349	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1229492006350	HTH domain; Region: HTH_11; pfam08279
1229492006351	Mga helix-turn-helix domain; Region: Mga; pfam05043
1229492006352	PRD domain; Region: PRD; pfam00874
1229492006353	PRD domain; Region: PRD; pfam00874
1229492006354	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1229492006355	active site
1229492006356	P-loop; other site
1229492006357	phosphorylation site [posttranslational modification]
1229492006358	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1229492006359	active site
1229492006360	phosphorylation site [posttranslational modification]
1229492006361	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492006362	active site
1229492006363	phosphorylation site [posttranslational modification]
1229492006364	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1229492006365	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1229492006366	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1229492006367	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492006368	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1229492006369	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006370	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006371	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006372	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006373	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006374	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006375	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1229492006376	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1229492006377	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1229492006378	active site
1229492006379	substrate binding site [chemical binding]; other site
1229492006380	metal binding site [ion binding]; metal-binding site
1229492006381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1229492006382	YbbR-like protein; Region: YbbR; pfam07949
1229492006383	TIGR00159 family protein; Region: TIGR00159
1229492006384	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1229492006385	Arginase family; Region: Arginase; cd09989
1229492006386	agmatinase; Region: agmatinase; TIGR01230
1229492006387	active site
1229492006388	Mn binding site [ion binding]; other site
1229492006389	oligomer interface [polypeptide binding]; other site
1229492006390	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1229492006391	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1229492006392	Walker A motif; other site
1229492006393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006394	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229492006395	putative substrate translocation pore; other site
1229492006396	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492006397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1229492006399	putative substrate translocation pore; other site
1229492006400	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1229492006401	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1229492006402	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1229492006403	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1229492006404	substrate binding site; other site
1229492006405	dimerization interface; other site
1229492006406	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1229492006407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1229492006408	Nucleoside recognition; Region: Gate; pfam07670
1229492006409	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229492006410	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492006411	ABC-ATPase subunit  interface; other site
1229492006412	dimer interface [polypeptide binding]; other site
1229492006413	putative PBP binding regions; other site
1229492006414	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1229492006415	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229492006416	ABC-ATPase subunit  interface; other site
1229492006417	dimer interface [polypeptide binding]; other site
1229492006418	putative PBP binding regions; other site
1229492006419	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1229492006420	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1229492006421	siderophore binding site; other site
1229492006422	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1229492006423	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1229492006424	dimer interface [polypeptide binding]; other site
1229492006425	active site
1229492006426	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229492006427	substrate binding site [chemical binding]; other site
1229492006428	catalytic residue [active]
1229492006429	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1229492006430	IucA / IucC family; Region: IucA_IucC; pfam04183
1229492006431	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1229492006432	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229492006433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006434	putative substrate translocation pore; other site
1229492006435	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1229492006436	IucA / IucC family; Region: IucA_IucC; pfam04183
1229492006437	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1229492006438	Asp23 family; Region: Asp23; pfam03780
1229492006439	Small integral membrane protein [Function unknown]; Region: COG5547
1229492006440	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1229492006441	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1229492006442	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1229492006443	putative NAD(P) binding site [chemical binding]; other site
1229492006444	dimer interface [polypeptide binding]; other site
1229492006445	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1229492006446	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1229492006447	NAD(P) binding site [chemical binding]; other site
1229492006448	substrate binding site [chemical binding]; other site
1229492006449	dimer interface [polypeptide binding]; other site
1229492006450	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1229492006451	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1229492006452	beta-galactosidase; Region: BGL; TIGR03356
1229492006453	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1229492006454	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1229492006455	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1229492006456	active site
1229492006457	P-loop; other site
1229492006458	phosphorylation site [posttranslational modification]
1229492006459	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1229492006460	methionine cluster; other site
1229492006461	active site
1229492006462	phosphorylation site [posttranslational modification]
1229492006463	metal binding site [ion binding]; metal-binding site
1229492006464	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1229492006465	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1229492006466	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1229492006467	putative substrate binding site [chemical binding]; other site
1229492006468	putative ATP binding site [chemical binding]; other site
1229492006469	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1229492006470	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1229492006471	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229492006472	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1229492006473	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229492006474	NAD-dependent deacetylase; Provisional; Region: PRK00481
1229492006475	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1229492006476	NAD+ binding site [chemical binding]; other site
1229492006477	substrate binding site [chemical binding]; other site
1229492006478	putative Zn binding site [ion binding]; other site
1229492006479	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
1229492006480	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229492006481	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229492006482	active site
1229492006483	catalytic tetrad [active]
1229492006484	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229492006485	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1229492006486	DNA binding residues [nucleotide binding]
1229492006487	putative dimer interface [polypeptide binding]; other site
1229492006488	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1229492006489	substrate binding site [chemical binding]; other site
1229492006490	catalytic residues [active]
1229492006491	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1229492006492	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229492006493	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1229492006494	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229492006495	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229492006496	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1229492006497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1229492006498	active site
1229492006499	motif I; other site
1229492006500	motif II; other site
1229492006501	MAP domain; Region: MAP; pfam03642
1229492006502	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1229492006503	acetolactate synthase; Reviewed; Region: PRK08617
1229492006504	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229492006505	PYR/PP interface [polypeptide binding]; other site
1229492006506	dimer interface [polypeptide binding]; other site
1229492006507	TPP binding site [chemical binding]; other site
1229492006508	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229492006509	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1229492006510	TPP-binding site [chemical binding]; other site
1229492006511	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229492006512	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229492006513	Integrase core domain; Region: rve; pfam00665
1229492006514	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1229492006515	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1229492006516	23S rRNA interface [nucleotide binding]; other site
1229492006517	L3 interface [polypeptide binding]; other site
1229492006518	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1229492006519	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1229492006520	dimerization interface 3.5A [polypeptide binding]; other site
1229492006521	active site
1229492006522	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1229492006523	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
1229492006524	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229492006525	Walker A/P-loop; other site
1229492006526	ATP binding site [chemical binding]; other site
1229492006527	Q-loop/lid; other site
1229492006528	ABC transporter signature motif; other site
1229492006529	Walker B; other site
1229492006530	D-loop; other site
1229492006531	H-loop/switch region; other site
1229492006532	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
1229492006533	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229492006534	Walker A/P-loop; other site
1229492006535	ATP binding site [chemical binding]; other site
1229492006536	Q-loop/lid; other site
1229492006537	ABC transporter signature motif; other site
1229492006538	Walker B; other site
1229492006539	D-loop; other site
1229492006540	H-loop/switch region; other site
1229492006541	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1229492006542	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1229492006543	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1229492006544	alphaNTD homodimer interface [polypeptide binding]; other site
1229492006545	alphaNTD - beta interaction site [polypeptide binding]; other site
1229492006546	alphaNTD - beta' interaction site [polypeptide binding]; other site
1229492006547	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1229492006548	30S ribosomal protein S11; Validated; Region: PRK05309
1229492006549	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1229492006550	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1229492006551	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1229492006552	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1229492006553	rRNA binding site [nucleotide binding]; other site
1229492006554	predicted 30S ribosome binding site; other site
1229492006555	adenylate kinase; Reviewed; Region: adk; PRK00279
1229492006556	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1229492006557	AMP-binding site [chemical binding]; other site
1229492006558	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1229492006559	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1229492006560	SecY translocase; Region: SecY; pfam00344
1229492006561	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1229492006562	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1229492006563	23S rRNA binding site [nucleotide binding]; other site
1229492006564	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1229492006565	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1229492006566	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1229492006567	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1229492006568	5S rRNA interface [nucleotide binding]; other site
1229492006569	L27 interface [polypeptide binding]; other site
1229492006570	23S rRNA interface [nucleotide binding]; other site
1229492006571	L5 interface [polypeptide binding]; other site
1229492006572	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1229492006573	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1229492006574	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1229492006575	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1229492006576	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1229492006577	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1229492006578	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1229492006579	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1229492006580	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1229492006581	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1229492006582	RNA binding site [nucleotide binding]; other site
1229492006583	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1229492006584	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1229492006585	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1229492006586	23S rRNA interface [nucleotide binding]; other site
1229492006587	putative translocon interaction site; other site
1229492006588	signal recognition particle (SRP54) interaction site; other site
1229492006589	L23 interface [polypeptide binding]; other site
1229492006590	trigger factor interaction site; other site
1229492006591	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1229492006592	23S rRNA interface [nucleotide binding]; other site
1229492006593	5S rRNA interface [nucleotide binding]; other site
1229492006594	putative antibiotic binding site [chemical binding]; other site
1229492006595	L25 interface [polypeptide binding]; other site
1229492006596	L27 interface [polypeptide binding]; other site
1229492006597	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1229492006598	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1229492006599	G-X-X-G motif; other site
1229492006600	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1229492006601	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1229492006602	putative translocon binding site; other site
1229492006603	protein-rRNA interface [nucleotide binding]; other site
1229492006604	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1229492006605	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1229492006606	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1229492006607	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1229492006608	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1229492006609	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1229492006610	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1229492006611	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1229492006612	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1229492006613	DNA topoisomerase III; Provisional; Region: PRK07726
1229492006614	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1229492006615	active site
1229492006616	putative interdomain interaction site [polypeptide binding]; other site
1229492006617	putative metal-binding site [ion binding]; other site
1229492006618	putative nucleotide binding site [chemical binding]; other site
1229492006619	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1229492006620	domain I; other site
1229492006621	DNA binding groove [nucleotide binding]
1229492006622	phosphate binding site [ion binding]; other site
1229492006623	domain II; other site
1229492006624	domain III; other site
1229492006625	nucleotide binding site [chemical binding]; other site
1229492006626	catalytic site [active]
1229492006627	domain IV; other site
1229492006628	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1229492006629	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492006630	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229492006631	Coenzyme A binding pocket [chemical binding]; other site
1229492006632	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1229492006633	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1229492006634	Predicted permeases [General function prediction only]; Region: COG0679
1229492006635	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229492006636	Protein export membrane protein; Region: SecD_SecF; cl14618
1229492006637	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1229492006638	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1229492006639	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1229492006640	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1229492006641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006642	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492006643	putative substrate translocation pore; other site
1229492006644	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492006645	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229492006646	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1229492006647	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492006648	FeS/SAM binding site; other site
1229492006649	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1229492006650	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1229492006651	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1229492006652	GTP binding site; other site
1229492006653	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1229492006654	MoaE interaction surface [polypeptide binding]; other site
1229492006655	MoeB interaction surface [polypeptide binding]; other site
1229492006656	thiocarboxylated glycine; other site
1229492006657	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1229492006658	MoaE homodimer interface [polypeptide binding]; other site
1229492006659	MoaD interaction [polypeptide binding]; other site
1229492006660	active site residues [active]
1229492006661	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1229492006662	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1229492006663	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1229492006664	dimer interface [polypeptide binding]; other site
1229492006665	putative functional site; other site
1229492006666	putative MPT binding site; other site
1229492006667	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1229492006668	trimer interface [polypeptide binding]; other site
1229492006669	dimer interface [polypeptide binding]; other site
1229492006670	putative active site [active]
1229492006671	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1229492006672	MPT binding site; other site
1229492006673	trimer interface [polypeptide binding]; other site
1229492006674	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1229492006675	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1229492006676	ATP binding site [chemical binding]; other site
1229492006677	substrate interface [chemical binding]; other site
1229492006678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492006679	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1229492006680	Walker A/P-loop; other site
1229492006681	ATP binding site [chemical binding]; other site
1229492006682	Q-loop/lid; other site
1229492006683	ABC transporter signature motif; other site
1229492006684	Walker B; other site
1229492006685	D-loop; other site
1229492006686	H-loop/switch region; other site
1229492006687	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1229492006688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492006689	dimer interface [polypeptide binding]; other site
1229492006690	conserved gate region; other site
1229492006691	putative PBP binding loops; other site
1229492006692	ABC-ATPase subunit interface; other site
1229492006693	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1229492006694	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229492006695	substrate binding pocket [chemical binding]; other site
1229492006696	membrane-bound complex binding site; other site
1229492006697	hinge residues; other site
1229492006698	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1229492006699	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492006700	Coenzyme A binding pocket [chemical binding]; other site
1229492006701	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1229492006702	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1229492006703	active site
1229492006704	dimerization interface [polypeptide binding]; other site
1229492006705	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1229492006706	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1229492006707	intersubunit interface [polypeptide binding]; other site
1229492006708	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229492006709	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1229492006710	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1229492006711	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1229492006712	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1229492006713	alpha-gamma subunit interface [polypeptide binding]; other site
1229492006714	beta-gamma subunit interface [polypeptide binding]; other site
1229492006715	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1229492006716	gamma-beta subunit interface [polypeptide binding]; other site
1229492006717	alpha-beta subunit interface [polypeptide binding]; other site
1229492006718	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1229492006719	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1229492006720	subunit interactions [polypeptide binding]; other site
1229492006721	active site
1229492006722	flap region; other site
1229492006723	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1229492006724	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1229492006725	dimer interface [polypeptide binding]; other site
1229492006726	catalytic residues [active]
1229492006727	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1229492006728	UreF; Region: UreF; pfam01730
1229492006729	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229492006730	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1229492006731	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492006732	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492006733	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1229492006734	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229492006735	Helix-turn-helix domain; Region: HTH_18; pfam12833
1229492006736	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229492006737	Surface antigen [General function prediction only]; Region: COG3942
1229492006738	CHAP domain; Region: CHAP; pfam05257
1229492006739	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1229492006740	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1229492006741	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1229492006742	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1229492006743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
1229492006744	Surface antigen [General function prediction only]; Region: COG3942
1229492006745	CHAP domain; Region: CHAP; pfam05257
1229492006746	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1229492006747	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1229492006748	putative ligand binding site [chemical binding]; other site
1229492006749	putative NAD binding site [chemical binding]; other site
1229492006750	catalytic site [active]
1229492006751	hypothetical protein; Provisional; Region: PRK06753
1229492006752	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229492006753	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1229492006754	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1229492006755	Lysozyme subfamily 2; Region: LYZ2; smart00047
1229492006756	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1229492006757	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1229492006758	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1229492006759	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1229492006760	4Fe-4S binding domain; Region: Fer4; pfam00037
1229492006761	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1229492006762	[4Fe-4S] binding site [ion binding]; other site
1229492006763	molybdopterin cofactor binding site; other site
1229492006764	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1229492006765	molybdopterin cofactor binding site; other site
1229492006766	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1229492006767	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1229492006768	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1229492006769	active site
1229492006770	Predicted transcriptional regulator [Transcription]; Region: COG2378
1229492006771	HTH domain; Region: HTH_11; pfam08279
1229492006772	CAAX protease self-immunity; Region: Abi; pfam02517
1229492006773	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229492006774	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229492006775	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229492006776	putative active site [active]
1229492006777	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229492006778	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1229492006779	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492006780	active site
1229492006781	motif I; other site
1229492006782	motif II; other site
1229492006783	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1229492006784	Sodium Bile acid symporter family; Region: SBF; pfam01758
1229492006785	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1229492006786	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492006787	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492006788	active site turn [active]
1229492006789	phosphorylation site [posttranslational modification]
1229492006790	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229492006791	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229492006792	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229492006793	putative active site [active]
1229492006794	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1229492006795	putative hydrophobic ligand binding site [chemical binding]; other site
1229492006796	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1229492006797	oxidoreductase; Provisional; Region: PRK06128
1229492006798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492006799	NAD(P) binding site [chemical binding]; other site
1229492006800	active site
1229492006801	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1229492006802	amidohydrolase; Region: amidohydrolases; TIGR01891
1229492006803	metal binding site [ion binding]; metal-binding site
1229492006804	dimer interface [polypeptide binding]; other site
1229492006805	imidazolonepropionase; Validated; Region: PRK09356
1229492006806	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1229492006807	active site
1229492006808	urocanate hydratase; Provisional; Region: PRK05414
1229492006809	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229492006810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229492006811	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229492006812	dimerization interface [polypeptide binding]; other site
1229492006813	formimidoylglutamase; Provisional; Region: PRK13775
1229492006814	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1229492006815	putative active site [active]
1229492006816	putative metal binding site [ion binding]; other site
1229492006817	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1229492006818	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1229492006819	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229492006820	active site
1229492006821	dimer interface [polypeptide binding]; other site
1229492006822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1229492006823	MOSC domain; Region: MOSC; pfam03473
1229492006824	3-alpha domain; Region: 3-alpha; pfam03475
1229492006825	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1229492006826	active site
1229492006827	catalytic residues [active]
1229492006828	Uncharacterized conserved protein [Function unknown]; Region: COG1742
1229492006829	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1229492006830	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1229492006831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492006832	Walker A/P-loop; other site
1229492006833	ATP binding site [chemical binding]; other site
1229492006834	Q-loop/lid; other site
1229492006835	ABC transporter signature motif; other site
1229492006836	Walker B; other site
1229492006837	D-loop; other site
1229492006838	H-loop/switch region; other site
1229492006839	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1229492006840	Predicted membrane protein [Function unknown]; Region: COG3152
1229492006841	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1229492006842	active site
1229492006843	DNA binding site [nucleotide binding]
1229492006844	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
1229492006845	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1229492006846	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1229492006847	homotetramer interface [polypeptide binding]; other site
1229492006848	FMN binding site [chemical binding]; other site
1229492006849	homodimer contacts [polypeptide binding]; other site
1229492006850	putative active site [active]
1229492006851	putative substrate binding site [chemical binding]; other site
1229492006852	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1229492006853	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1229492006854	oligomer interface [polypeptide binding]; other site
1229492006855	metal binding site [ion binding]; metal-binding site
1229492006856	metal binding site [ion binding]; metal-binding site
1229492006857	putative Cl binding site [ion binding]; other site
1229492006858	aspartate ring; other site
1229492006859	basic sphincter; other site
1229492006860	hydrophobic gate; other site
1229492006861	periplasmic entrance; other site
1229492006862	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229492006863	active site
1229492006864	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1229492006865	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1229492006866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006867	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229492006868	putative substrate translocation pore; other site
1229492006869	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1229492006870	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1229492006871	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1229492006872	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229492006873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229492006874	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1229492006875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006876	putative substrate translocation pore; other site
1229492006877	Predicted membrane protein [Function unknown]; Region: COG4640
1229492006878	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1229492006879	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492006880	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229492006881	putative Zn2+ binding site [ion binding]; other site
1229492006882	putative DNA binding site [nucleotide binding]; other site
1229492006883	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1229492006884	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1229492006885	putative active site [active]
1229492006886	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229492006887	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229492006888	Walker A/P-loop; other site
1229492006889	ATP binding site [chemical binding]; other site
1229492006890	Q-loop/lid; other site
1229492006891	ABC transporter signature motif; other site
1229492006892	Walker B; other site
1229492006893	D-loop; other site
1229492006894	H-loop/switch region; other site
1229492006895	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229492006896	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229492006897	FtsX-like permease family; Region: FtsX; pfam02687
1229492006898	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492006899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492006900	active site
1229492006901	phosphorylation site [posttranslational modification]
1229492006902	intermolecular recognition site; other site
1229492006903	dimerization interface [polypeptide binding]; other site
1229492006904	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492006905	DNA binding site [nucleotide binding]
1229492006906	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229492006907	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229492006908	dimerization interface [polypeptide binding]; other site
1229492006909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229492006910	dimer interface [polypeptide binding]; other site
1229492006911	phosphorylation site [posttranslational modification]
1229492006912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492006913	ATP binding site [chemical binding]; other site
1229492006914	Mg2+ binding site [ion binding]; other site
1229492006915	G-X-G motif; other site
1229492006916	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1229492006917	LytTr DNA-binding domain; Region: LytTR; smart00850
1229492006918	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1229492006919	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
1229492006920	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1229492006921	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1229492006922	L-lactate permease; Region: Lactate_perm; cl00701
1229492006923	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229492006924	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229492006925	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229492006926	Integrase core domain; Region: rve; pfam00665
1229492006927	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492006928	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229492006929	Coenzyme A binding pocket [chemical binding]; other site
1229492006930	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229492006931	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1229492006932	NAD(P) binding site [chemical binding]; other site
1229492006933	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492006934	Coenzyme A binding pocket [chemical binding]; other site
1229492006935	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229492006936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492006937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492006938	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
1229492006939	Predicted membrane protein [Function unknown]; Region: COG1511
1229492006940	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229492006941	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1229492006942	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492006943	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1229492006944	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1229492006945	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1229492006946	Cl binding site [ion binding]; other site
1229492006947	oligomer interface [polypeptide binding]; other site
1229492006948	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1229492006949	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492006950	active site turn [active]
1229492006951	phosphorylation site [posttranslational modification]
1229492006952	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492006953	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1229492006954	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229492006955	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229492006956	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1229492006957	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1229492006958	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229492006959	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1229492006960	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
1229492006961	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492006962	MarR family; Region: MarR_2; pfam12802
1229492006963	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229492006964	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1229492006965	putative dimer interface [polypeptide binding]; other site
1229492006966	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1229492006967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492006968	putative substrate translocation pore; other site
1229492006969	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1229492006970	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1229492006971	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229492006972	DNA binding residues [nucleotide binding]
1229492006973	dimer interface [polypeptide binding]; other site
1229492006974	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1229492006975	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229492006976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492006977	active site
1229492006978	phosphorylation site [posttranslational modification]
1229492006979	intermolecular recognition site; other site
1229492006980	dimerization interface [polypeptide binding]; other site
1229492006981	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229492006982	DNA binding residues [nucleotide binding]
1229492006983	dimerization interface [polypeptide binding]; other site
1229492006984	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229492006985	Histidine kinase; Region: HisKA_3; pfam07730
1229492006986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492006987	ATP binding site [chemical binding]; other site
1229492006988	Mg2+ binding site [ion binding]; other site
1229492006989	G-X-G motif; other site
1229492006990	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1229492006991	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1229492006992	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1229492006993	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1229492006994	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1229492006995	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1229492006996	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1229492006997	[4Fe-4S] binding site [ion binding]; other site
1229492006998	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1229492006999	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1229492007000	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1229492007001	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1229492007002	molybdopterin cofactor binding site; other site
1229492007003	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1229492007004	active site
1229492007005	SAM binding site [chemical binding]; other site
1229492007006	homodimer interface [polypeptide binding]; other site
1229492007007	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1229492007008	[2Fe-2S] cluster binding site [ion binding]; other site
1229492007009	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1229492007010	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492007011	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229492007012	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229492007013	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229492007014	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1229492007015	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1229492007016	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1229492007017	putative active site [active]
1229492007018	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1229492007019	active site
1229492007020	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229492007021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492007022	Coenzyme A binding pocket [chemical binding]; other site
1229492007023	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1229492007024	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1229492007025	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1229492007026	putative hydrophobic ligand binding site [chemical binding]; other site
1229492007027	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1229492007028	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1229492007029	intersubunit interface [polypeptide binding]; other site
1229492007030	YodA lipocalin-like domain; Region: YodA; pfam09223
1229492007031	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1229492007032	Thioredoxin; Region: Thioredoxin_4; pfam13462
1229492007033	FemAB family; Region: FemAB; pfam02388
1229492007034	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229492007035	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229492007036	Walker A/P-loop; other site
1229492007037	ATP binding site [chemical binding]; other site
1229492007038	Q-loop/lid; other site
1229492007039	ABC transporter signature motif; other site
1229492007040	Walker B; other site
1229492007041	D-loop; other site
1229492007042	H-loop/switch region; other site
1229492007043	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229492007044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492007045	dimer interface [polypeptide binding]; other site
1229492007046	conserved gate region; other site
1229492007047	putative PBP binding loops; other site
1229492007048	ABC-ATPase subunit interface; other site
1229492007049	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229492007050	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229492007051	substrate binding pocket [chemical binding]; other site
1229492007052	membrane-bound complex binding site; other site
1229492007053	hinge residues; other site
1229492007054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007055	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492007056	putative substrate translocation pore; other site
1229492007057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007058	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229492007059	catalytic core [active]
1229492007060	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229492007061	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1229492007062	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1229492007063	B domain; Region: B; pfam02216
1229492007064	B domain; Region: B; pfam02216
1229492007065	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
1229492007066	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1229492007067	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
1229492007068	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1229492007069	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
1229492007070	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1229492007071	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1229492007072	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1229492007073	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229492007074	catalytic residue [active]
1229492007075	biotin synthase; Validated; Region: PRK06256
1229492007076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492007077	FeS/SAM binding site; other site
1229492007078	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1229492007079	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229492007080	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1229492007081	inhibitor-cofactor binding pocket; inhibition site
1229492007082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492007083	catalytic residue [active]
1229492007084	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1229492007085	AAA domain; Region: AAA_26; pfam13500
1229492007086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492007087	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1229492007088	Walker A/P-loop; other site
1229492007089	ATP binding site [chemical binding]; other site
1229492007090	Q-loop/lid; other site
1229492007091	ABC transporter signature motif; other site
1229492007092	Walker B; other site
1229492007093	D-loop; other site
1229492007094	H-loop/switch region; other site
1229492007095	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229492007096	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229492007097	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492007098	Walker A/P-loop; other site
1229492007099	ATP binding site [chemical binding]; other site
1229492007100	Q-loop/lid; other site
1229492007101	ABC transporter signature motif; other site
1229492007102	Walker B; other site
1229492007103	D-loop; other site
1229492007104	H-loop/switch region; other site
1229492007105	Predicted membrane protein [Function unknown]; Region: COG2246
1229492007106	GtrA-like protein; Region: GtrA; pfam04138
1229492007107	glycerate kinase; Region: TIGR00045
1229492007108	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1229492007109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007110	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1229492007111	putative substrate translocation pore; other site
1229492007112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1229492007113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
1229492007114	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1229492007115	putative phosphoesterase; Region: acc_ester; TIGR03729
1229492007116	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229492007117	Spore germination protein; Region: Spore_permease; cl17796
1229492007118	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229492007119	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1229492007120	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229492007121	Beta-lactamase; Region: Beta-lactamase; pfam00144
1229492007122	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229492007123	extended (e) SDRs; Region: SDR_e; cd08946
1229492007124	NAD(P) binding site [chemical binding]; other site
1229492007125	active site
1229492007126	substrate binding site [chemical binding]; other site
1229492007127	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1229492007128	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229492007129	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229492007130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007131	putative substrate translocation pore; other site
1229492007132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492007134	dimer interface [polypeptide binding]; other site
1229492007135	conserved gate region; other site
1229492007136	ABC-ATPase subunit interface; other site
1229492007137	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1229492007138	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1229492007139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492007140	dimer interface [polypeptide binding]; other site
1229492007141	conserved gate region; other site
1229492007142	putative PBP binding loops; other site
1229492007143	ABC-ATPase subunit interface; other site
1229492007144	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1229492007145	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1229492007146	Walker A/P-loop; other site
1229492007147	ATP binding site [chemical binding]; other site
1229492007148	Q-loop/lid; other site
1229492007149	ABC transporter signature motif; other site
1229492007150	Walker B; other site
1229492007151	D-loop; other site
1229492007152	H-loop/switch region; other site
1229492007153	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1229492007154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1229492007155	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1229492007156	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1229492007157	amino acid transporter; Region: 2A0306; TIGR00909
1229492007158	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1229492007159	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1229492007160	substrate binding pocket [chemical binding]; other site
1229492007161	catalytic triad [active]
1229492007162	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229492007163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007164	putative substrate translocation pore; other site
1229492007165	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1229492007166	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1229492007167	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229492007168	Walker A/P-loop; other site
1229492007169	ATP binding site [chemical binding]; other site
1229492007170	Q-loop/lid; other site
1229492007171	ABC transporter signature motif; other site
1229492007172	Walker B; other site
1229492007173	D-loop; other site
1229492007174	H-loop/switch region; other site
1229492007175	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1229492007176	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1229492007177	oligomer interface [polypeptide binding]; other site
1229492007178	active site
1229492007179	metal binding site [ion binding]; metal-binding site
1229492007180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1229492007181	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1229492007182	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1229492007183	active site
1229492007184	FMN binding site [chemical binding]; other site
1229492007185	substrate binding site [chemical binding]; other site
1229492007186	3Fe-4S cluster binding site [ion binding]; other site
1229492007187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007188	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492007189	putative substrate translocation pore; other site
1229492007190	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229492007191	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492007192	Walker A/P-loop; other site
1229492007193	ATP binding site [chemical binding]; other site
1229492007194	Q-loop/lid; other site
1229492007195	ABC transporter signature motif; other site
1229492007196	Walker B; other site
1229492007197	D-loop; other site
1229492007198	H-loop/switch region; other site
1229492007199	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229492007200	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1229492007201	Walker A/P-loop; other site
1229492007202	ATP binding site [chemical binding]; other site
1229492007203	Q-loop/lid; other site
1229492007204	ABC transporter signature motif; other site
1229492007205	Walker B; other site
1229492007206	D-loop; other site
1229492007207	H-loop/switch region; other site
1229492007208	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229492007209	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1229492007210	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1229492007211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492007212	dimer interface [polypeptide binding]; other site
1229492007213	conserved gate region; other site
1229492007214	putative PBP binding loops; other site
1229492007215	ABC-ATPase subunit interface; other site
1229492007216	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229492007217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229492007218	dimer interface [polypeptide binding]; other site
1229492007219	conserved gate region; other site
1229492007220	putative PBP binding loops; other site
1229492007221	ABC-ATPase subunit interface; other site
1229492007222	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229492007223	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1229492007224	substrate binding site [chemical binding]; other site
1229492007225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1229492007226	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1229492007227	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229492007228	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1229492007229	short chain dehydrogenase; Validated; Region: PRK08589
1229492007230	classical (c) SDRs; Region: SDR_c; cd05233
1229492007231	NAD(P) binding site [chemical binding]; other site
1229492007232	active site
1229492007233	AbgT putative transporter family; Region: ABG_transport; pfam03806
1229492007234	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1229492007235	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1229492007236	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229492007237	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492007238	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492007239	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492007240	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492007241	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1229492007242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229492007243	Helix-turn-helix domain; Region: HTH_28; pfam13518
1229492007244	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1229492007245	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1229492007246	classical (c) SDRs; Region: SDR_c; cd05233
1229492007247	NAD(P) binding site [chemical binding]; other site
1229492007248	active site
1229492007249	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1229492007250	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1229492007251	nucleophilic elbow; other site
1229492007252	catalytic triad; other site
1229492007253	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492007254	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492007255	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1229492007256	EcoRII C terminal; Region: EcoRII-C; pfam09019
1229492007257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492007258	non-specific DNA binding site [nucleotide binding]; other site
1229492007259	salt bridge; other site
1229492007260	sequence-specific DNA binding site [nucleotide binding]; other site
1229492007261	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1229492007262	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1229492007263	cofactor binding site; other site
1229492007264	DNA binding site [nucleotide binding]
1229492007265	substrate interaction site [chemical binding]; other site
1229492007266	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1229492007267	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1229492007268	active site
1229492007269	substrate binding site [chemical binding]; other site
1229492007270	metal binding site [ion binding]; metal-binding site
1229492007271	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1229492007272	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1229492007273	active site
1229492007274	tetramer interface; other site
1229492007275	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492007276	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492007277	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492007278	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492007279	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492007280	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1229492007281	GntP family permease; Region: GntP_permease; pfam02447
1229492007282	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1229492007283	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1229492007284	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1229492007285	N- and C-terminal domain interface [polypeptide binding]; other site
1229492007286	active site
1229492007287	catalytic site [active]
1229492007288	metal binding site [ion binding]; metal-binding site
1229492007289	carbohydrate binding site [chemical binding]; other site
1229492007290	ATP binding site [chemical binding]; other site
1229492007291	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229492007292	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229492007293	DNA-binding site [nucleotide binding]; DNA binding site
1229492007294	FCD domain; Region: FCD; pfam07729
1229492007295	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1229492007296	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229492007297	DNA binding residues [nucleotide binding]
1229492007298	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229492007299	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1229492007300	synthetase active site [active]
1229492007301	NTP binding site [chemical binding]; other site
1229492007302	metal binding site [ion binding]; metal-binding site
1229492007303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1229492007304	Predicted membrane protein [Function unknown]; Region: COG1289
1229492007305	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229492007306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007307	D-galactonate transporter; Region: 2A0114; TIGR00893
1229492007308	putative substrate translocation pore; other site
1229492007309	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1229492007310	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1229492007311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229492007312	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229492007313	putative substrate translocation pore; other site
1229492007314	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492007315	MarR family; Region: MarR; pfam01047
1229492007316	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1229492007317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229492007318	Walker A/P-loop; other site
1229492007319	ATP binding site [chemical binding]; other site
1229492007320	Q-loop/lid; other site
1229492007321	ABC transporter signature motif; other site
1229492007322	Walker B; other site
1229492007323	D-loop; other site
1229492007324	H-loop/switch region; other site
1229492007325	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1229492007326	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1229492007327	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1229492007328	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1229492007329	Predicted esterase [General function prediction only]; Region: COG0400
1229492007330	putative hydrolase; Provisional; Region: PRK11460
1229492007331	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1229492007332	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229492007333	Zn binding site [ion binding]; other site
1229492007334	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1229492007335	Zn binding site [ion binding]; other site
1229492007336	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492007337	MarR family; Region: MarR; pfam01047
1229492007338	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1229492007339	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1229492007340	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1229492007341	putative metal binding site [ion binding]; other site
1229492007342	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229492007343	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1229492007344	dimer interface [polypeptide binding]; other site
1229492007345	FMN binding site [chemical binding]; other site
1229492007346	D-lactate dehydrogenase; Provisional; Region: PRK12480
1229492007347	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1229492007348	homodimer interface [polypeptide binding]; other site
1229492007349	ligand binding site [chemical binding]; other site
1229492007350	NAD binding site [chemical binding]; other site
1229492007351	catalytic site [active]
1229492007352	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1229492007353	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229492007354	active site
1229492007355	motif I; other site
1229492007356	motif II; other site
1229492007357	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1229492007358	active site
1229492007359	catalytic site [active]
1229492007360	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1229492007361	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492007362	Coenzyme A binding pocket [chemical binding]; other site
1229492007363	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229492007364	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1229492007365	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1229492007366	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1229492007367	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1229492007368	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229492007369	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1229492007370	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229492007371	EamA-like transporter family; Region: EamA; pfam00892
1229492007372	EamA-like transporter family; Region: EamA; pfam00892
1229492007373	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1229492007374	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1229492007375	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229492007376	catalytic residues [active]
1229492007377	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229492007378	active site
1229492007379	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229492007380	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1229492007381	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229492007382	active site turn [active]
1229492007383	phosphorylation site [posttranslational modification]
1229492007384	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1229492007385	HPr interaction site; other site
1229492007386	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229492007387	active site
1229492007388	phosphorylation site [posttranslational modification]
1229492007389	pyruvate oxidase; Provisional; Region: PRK08611
1229492007390	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1229492007391	PYR/PP interface [polypeptide binding]; other site
1229492007392	tetramer interface [polypeptide binding]; other site
1229492007393	dimer interface [polypeptide binding]; other site
1229492007394	TPP binding site [chemical binding]; other site
1229492007395	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229492007396	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1229492007397	TPP-binding site [chemical binding]; other site
1229492007398	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1229492007399	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1229492007400	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229492007401	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229492007402	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1229492007403	putative dimerization interface [polypeptide binding]; other site
1229492007404	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1229492007405	Surface antigen [General function prediction only]; Region: COG3942
1229492007406	CHAP domain; Region: CHAP; pfam05257
1229492007407	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1229492007408	homodimer interface [polypeptide binding]; other site
1229492007409	catalytic residues [active]
1229492007410	NAD binding site [chemical binding]; other site
1229492007411	substrate binding pocket [chemical binding]; other site
1229492007412	flexible flap; other site
1229492007413	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1229492007414	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1229492007415	dimer interface [polypeptide binding]; other site
1229492007416	active site
1229492007417	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1229492007418	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1229492007419	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1229492007420	DNA binding site [nucleotide binding]
1229492007421	active site
1229492007422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492007423	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229492007424	Walker A motif; other site
1229492007425	ATP binding site [chemical binding]; other site
1229492007426	Walker B motif; other site
1229492007427	arginine finger; other site
1229492007428	UvrB/uvrC motif; Region: UVR; pfam02151
1229492007429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229492007430	Walker A motif; other site
1229492007431	ATP binding site [chemical binding]; other site
1229492007432	Walker B motif; other site
1229492007433	arginine finger; other site
1229492007434	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229492007435	Virus attachment protein p12 family; Region: P12; pfam12669
1229492007436	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1229492007437	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1229492007438	G1 box; other site
1229492007439	GTP/Mg2+ binding site [chemical binding]; other site
1229492007440	Switch I region; other site
1229492007441	G2 box; other site
1229492007442	G3 box; other site
1229492007443	Switch II region; other site
1229492007444	G4 box; other site
1229492007445	G5 box; other site
1229492007446	Nucleoside recognition; Region: Gate; pfam07670
1229492007447	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1229492007448	Nucleoside recognition; Region: Gate; pfam07670
1229492007449	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1229492007450	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1229492007451	Protein export membrane protein; Region: SecD_SecF; cl14618
1229492007452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492007453	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1229492007454	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1229492007455	Glutamate binding site [chemical binding]; other site
1229492007456	homodimer interface [polypeptide binding]; other site
1229492007457	NAD binding site [chemical binding]; other site
1229492007458	catalytic residues [active]
1229492007459	maltose O-acetyltransferase; Provisional; Region: PRK10092
1229492007460	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1229492007461	active site
1229492007462	substrate binding site [chemical binding]; other site
1229492007463	trimer interface [polypeptide binding]; other site
1229492007464	CoA binding site [chemical binding]; other site
1229492007465	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1229492007466	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1229492007467	metal-binding site [ion binding]
1229492007468	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1229492007469	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1229492007470	metal-binding site [ion binding]
1229492007471	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229492007472	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1229492007473	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1229492007474	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1229492007475	metal-binding site [ion binding]
1229492007476	D-lactate dehydrogenase; Validated; Region: PRK08605
1229492007477	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1229492007478	homodimer interface [polypeptide binding]; other site
1229492007479	ligand binding site [chemical binding]; other site
1229492007480	NAD binding site [chemical binding]; other site
1229492007481	catalytic site [active]
1229492007482	transaminase; Reviewed; Region: PRK08068
1229492007483	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229492007484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492007485	homodimer interface [polypeptide binding]; other site
1229492007486	catalytic residue [active]
1229492007487	phytoene desaturase; Region: crtI_fam; TIGR02734
1229492007488	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229492007489	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1229492007490	active site lid residues [active]
1229492007491	substrate binding pocket [chemical binding]; other site
1229492007492	catalytic residues [active]
1229492007493	substrate-Mg2+ binding site; other site
1229492007494	aspartate-rich region 1; other site
1229492007495	aspartate-rich region 2; other site
1229492007496	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229492007497	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229492007498	active site
1229492007499	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1229492007500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229492007501	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
1229492007502	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229492007503	Surface antigen [General function prediction only]; Region: COG3942
1229492007504	CHAP domain; Region: CHAP; pfam05257
1229492007505	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229492007506	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1229492007507	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1229492007508	catalytic triad [active]
1229492007509	catalytic triad [active]
1229492007510	oxyanion hole [active]
1229492007511	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229492007512	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229492007513	catalytic residue [active]
1229492007514	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1229492007515	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229492007516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492007517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492007518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
1229492007519	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1229492007520	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229492007521	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1229492007522	NmrA-like family; Region: NmrA; pfam05368
1229492007523	NADP binding site [chemical binding]; other site
1229492007524	active site
1229492007525	regulatory binding site [polypeptide binding]; other site
1229492007526	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
1229492007527	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492007528	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492007529	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1229492007530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229492007531	NAD(P) binding site [chemical binding]; other site
1229492007532	active site
1229492007533	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1229492007534	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229492007535	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1229492007536	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1229492007537	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1229492007538	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1229492007539	Nucleoside recognition; Region: Gate; pfam07670
1229492007540	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229492007541	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1229492007542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
1229492007543	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
1229492007544	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1229492007545	Phosphotransferase enzyme family; Region: APH; pfam01636
1229492007546	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1229492007547	active site
1229492007548	ATP binding site [chemical binding]; other site
1229492007549	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1229492007550	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1229492007551	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1229492007552	quinone interaction residues [chemical binding]; other site
1229492007553	active site
1229492007554	catalytic residues [active]
1229492007555	FMN binding site [chemical binding]; other site
1229492007556	substrate binding site [chemical binding]; other site
1229492007557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1229492007558	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1229492007559	dimer interface [polypeptide binding]; other site
1229492007560	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229492007561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492007562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492007563	Predicted acyl esterases [General function prediction only]; Region: COG2936
1229492007564	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1229492007565	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1229492007566	tetramerization interface [polypeptide binding]; other site
1229492007567	active site
1229492007568	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1229492007569	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1229492007570	active site
1229492007571	ATP-binding site [chemical binding]; other site
1229492007572	pantoate-binding site; other site
1229492007573	HXXH motif; other site
1229492007574	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1229492007575	oligomerization interface [polypeptide binding]; other site
1229492007576	active site
1229492007577	metal binding site [ion binding]; metal-binding site
1229492007578	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1229492007579	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229492007580	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229492007581	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1229492007582	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1229492007583	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1229492007584	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229492007585	NAD binding site [chemical binding]; other site
1229492007586	dimer interface [polypeptide binding]; other site
1229492007587	substrate binding site [chemical binding]; other site
1229492007588	amino acid transporter; Region: 2A0306; TIGR00909
1229492007589	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1229492007590	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229492007591	inhibitor-cofactor binding pocket; inhibition site
1229492007592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492007593	catalytic residue [active]
1229492007594	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1229492007595	catalytic residue [active]
1229492007596	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1229492007597	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1229492007598	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1229492007599	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229492007600	acyl-activating enzyme (AAE) consensus motif; other site
1229492007601	AMP binding site [chemical binding]; other site
1229492007602	active site
1229492007603	CoA binding site [chemical binding]; other site
1229492007604	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1229492007605	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1229492007606	choline dehydrogenase; Validated; Region: PRK02106
1229492007607	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229492007608	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1229492007609	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1229492007610	tetramerization interface [polypeptide binding]; other site
1229492007611	NAD(P) binding site [chemical binding]; other site
1229492007612	catalytic residues [active]
1229492007613	Predicted transcriptional regulators [Transcription]; Region: COG1510
1229492007614	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1229492007615	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1229492007616	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229492007617	FeS/SAM binding site; other site
1229492007618	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
1229492007619	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1229492007620	effector binding site; other site
1229492007621	active site
1229492007622	Zn binding site [ion binding]; other site
1229492007623	glycine loop; other site
1229492007624	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1229492007625	Citrate transporter; Region: CitMHS; pfam03600
1229492007626	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1229492007627	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1229492007628	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1229492007629	Flavodoxin; Region: Flavodoxin_1; pfam00258
1229492007630	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1229492007631	FAD binding pocket [chemical binding]; other site
1229492007632	FAD binding motif [chemical binding]; other site
1229492007633	catalytic residues [active]
1229492007634	NAD binding pocket [chemical binding]; other site
1229492007635	phosphate binding motif [ion binding]; other site
1229492007636	beta-alpha-beta structure motif; other site
1229492007637	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1229492007638	catalytic residues [active]
1229492007639	dimer interface [polypeptide binding]; other site
1229492007640	FtsX-like permease family; Region: FtsX; pfam02687
1229492007641	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229492007642	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229492007643	Walker A/P-loop; other site
1229492007644	ATP binding site [chemical binding]; other site
1229492007645	Q-loop/lid; other site
1229492007646	ABC transporter signature motif; other site
1229492007647	Walker B; other site
1229492007648	D-loop; other site
1229492007649	H-loop/switch region; other site
1229492007650	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229492007651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229492007652	ATP binding site [chemical binding]; other site
1229492007653	Mg2+ binding site [ion binding]; other site
1229492007654	G-X-G motif; other site
1229492007655	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229492007656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229492007657	active site
1229492007658	phosphorylation site [posttranslational modification]
1229492007659	intermolecular recognition site; other site
1229492007660	dimerization interface [polypeptide binding]; other site
1229492007661	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229492007662	DNA binding site [nucleotide binding]
1229492007663	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1229492007664	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1229492007665	dimer interface [polypeptide binding]; other site
1229492007666	active site
1229492007667	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1229492007668	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229492007669	MarR family; Region: MarR_2; pfam12802
1229492007670	Predicted esterase [General function prediction only]; Region: COG0627
1229492007671	S-formylglutathione hydrolase; Region: PLN02442
1229492007672	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1229492007673	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1229492007674	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229492007675	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229492007676	ligand binding site [chemical binding]; other site
1229492007677	flexible hinge region; other site
1229492007678	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1229492007679	carbamate kinase; Reviewed; Region: PRK12686
1229492007680	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1229492007681	putative substrate binding site [chemical binding]; other site
1229492007682	nucleotide binding site [chemical binding]; other site
1229492007683	nucleotide binding site [chemical binding]; other site
1229492007684	homodimer interface [polypeptide binding]; other site
1229492007685	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1229492007686	ornithine carbamoyltransferase; Validated; Region: PRK02102
1229492007687	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229492007688	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229492007689	arginine deiminase; Provisional; Region: PRK01388
1229492007690	Arginine repressor [Transcription]; Region: ArgR; COG1438
1229492007691	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1229492007692	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1229492007693	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1229492007694	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1229492007695	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1229492007696	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1229492007697	active site
1229492007698	Zn binding site [ion binding]; other site
1229492007699	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1229492007700	HTH domain; Region: HTH_11; pfam08279
1229492007701	PRD domain; Region: PRD; pfam00874
1229492007702	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1229492007703	active site
1229492007704	P-loop; other site
1229492007705	phosphorylation site [posttranslational modification]
1229492007706	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492007707	active site
1229492007708	phosphorylation site [posttranslational modification]
1229492007709	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1229492007710	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1229492007711	active site
1229492007712	P-loop; other site
1229492007713	phosphorylation site [posttranslational modification]
1229492007714	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1229492007715	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229492007716	active site
1229492007717	phosphorylation site [posttranslational modification]
1229492007718	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1229492007719	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1229492007720	Predicted membrane protein [Function unknown]; Region: COG1511
1229492007721	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229492007722	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1229492007723	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
1229492007724	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1229492007725	CHAP domain; Region: CHAP; pfam05257
1229492007726	Isochorismatase family; Region: Isochorismatase; pfam00857
1229492007727	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229492007728	catalytic triad [active]
1229492007729	conserved cis-peptide bond; other site
1229492007730	Predicted membrane protein [Function unknown]; Region: COG1511
1229492007731	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1229492007732	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229492007733	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1229492007734	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1229492007735	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1229492007736	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1229492007737	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1229492007738	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1229492007739	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1229492007740	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1229492007741	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229492007742	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1229492007743	SecY translocase; Region: SecY; pfam00344
1229492007744	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1229492007745	legume lectins; Region: lectin_L-type; cd01951
1229492007746	homotetramer interaction site [polypeptide binding]; other site
1229492007747	carbohydrate binding site [chemical binding]; other site
1229492007748	metal binding site [ion binding]; metal-binding site
1229492007749	Putative Ig domain; Region: He_PIG; pfam05345
1229492007750	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1229492007751	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1229492007752	methionine sulfoxide reductase A; Provisional; Region: PRK05528
1229492007753	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1229492007754	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229492007755	Coenzyme A binding pocket [chemical binding]; other site
1229492007756	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1229492007757	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1229492007758	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229492007759	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1229492007760	Chain length determinant protein; Region: Wzz; cl15801
1229492007761	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229492007762	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229492007763	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
1229492007764	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1229492007765	DXD motif; other site
1229492007766	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
1229492007767	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1229492007768	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1229492007769	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1229492007770	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1229492007771	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1229492007772	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1229492007773	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1229492007774	metal binding site [ion binding]; metal-binding site
1229492007775	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1229492007776	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1229492007777	substrate binding site [chemical binding]; other site
1229492007778	glutamase interaction surface [polypeptide binding]; other site
1229492007779	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1229492007780	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1229492007781	catalytic residues [active]
1229492007782	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
1229492007783	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1229492007784	putative active site [active]
1229492007785	oxyanion strand; other site
1229492007786	catalytic triad [active]
1229492007787	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1229492007788	putative active site pocket [active]
1229492007789	4-fold oligomerization interface [polypeptide binding]; other site
1229492007790	metal binding residues [ion binding]; metal-binding site
1229492007791	3-fold/trimer interface [polypeptide binding]; other site
1229492007792	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1229492007793	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229492007794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229492007795	homodimer interface [polypeptide binding]; other site
1229492007796	catalytic residue [active]
1229492007797	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1229492007798	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1229492007799	NAD binding site [chemical binding]; other site
1229492007800	dimerization interface [polypeptide binding]; other site
1229492007801	product binding site; other site
1229492007802	substrate binding site [chemical binding]; other site
1229492007803	zinc binding site [ion binding]; other site
1229492007804	catalytic residues [active]
1229492007805	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
1229492007806	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1229492007807	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
1229492007808	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1229492007809	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1229492007810	putative active site [active]
1229492007811	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1229492007812	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1229492007813	Strictosidine synthase; Region: Str_synth; pfam03088
1229492007814	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1229492007815	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1229492007816	active site residue [active]
1229492007817	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1229492007818	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1229492007819	putative substrate binding pocket [chemical binding]; other site
1229492007820	AC domain interface; other site
1229492007821	catalytic triad [active]
1229492007822	AB domain interface; other site
1229492007823	interchain disulfide; other site
1229492007824	hypothetical protein; Validated; Region: PRK07668
1229492007825	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229492007826	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229492007827	DinB superfamily; Region: DinB_2; pfam12867
1229492007828	Collagen binding domain; Region: Collagen_bind; pfam05737
1229492007829	Cna protein B-type domain; Region: Cna_B; pfam05738
1229492007830	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1229492007831	domain interaction interfaces [polypeptide binding]; other site
1229492007832	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1229492007833	domain interaction interfaces [polypeptide binding]; other site
1229492007834	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1229492007835	domain interaction interfaces [polypeptide binding]; other site
1229492007836	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1229492007837	domain interaction interfaces [polypeptide binding]; other site
1229492007838	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1229492007839	domain interaction interfaces [polypeptide binding]; other site
1229492007840	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1229492007841	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1229492007842	transmembrane helices; other site
1229492007843	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1229492007844	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1229492007845	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1229492007846	hypothetical protein; Provisional; Region: PRK07758
1229492007847	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1229492007848	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1229492007849	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1229492007850	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229492007851	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229492007852	Walker A/P-loop; other site
1229492007853	ATP binding site [chemical binding]; other site
1229492007854	Q-loop/lid; other site
1229492007855	ABC transporter signature motif; other site
1229492007856	Walker B; other site
1229492007857	D-loop; other site
1229492007858	H-loop/switch region; other site
1229492007859	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229492007860	FtsX-like permease family; Region: FtsX; pfam02687
1229492007861	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229492007862	DNA-binding site [nucleotide binding]; DNA binding site
1229492007863	RNA-binding motif; other site
1229492007864	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229492007865	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229492007866	non-specific DNA binding site [nucleotide binding]; other site
1229492007867	salt bridge; other site
1229492007868	sequence-specific DNA binding site [nucleotide binding]; other site
1229492007869	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1229492007870	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1229492007871	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1229492007872	ParB-like nuclease domain; Region: ParBc; pfam02195
1229492007873	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1229492007874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229492007875	S-adenosylmethionine binding site [chemical binding]; other site
1229492007876	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1229492007877	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1229492007878	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1229492007879	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1229492007880	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1229492007881	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1229492007882	G1 box; other site
1229492007883	GTP/Mg2+ binding site [chemical binding]; other site
1229492007884	Switch I region; other site
1229492007885	G2 box; other site
1229492007886	Switch II region; other site
1229492007887	G3 box; other site
1229492007888	G4 box; other site
1229492007889	G5 box; other site
1229492007890	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1229492007891	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1229492007892	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399