-- dump date   	20140620_073355
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1321369000001	Replication protein; Region: Rep_1; cl02412
1321369000002	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1321369000003	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1321369000004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369000005	Walker A motif; other site
1321369000006	ATP binding site [chemical binding]; other site
1321369000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1321369000008	Walker B motif; other site
1321369000009	arginine finger; other site
1321369000010	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1321369000011	DnaA box-binding interface [nucleotide binding]; other site
1321369000012	DNA polymerase III subunit beta; Validated; Region: PRK05643
1321369000013	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1321369000014	putative DNA binding surface [nucleotide binding]; other site
1321369000015	dimer interface [polypeptide binding]; other site
1321369000016	beta-clamp/clamp loader binding surface; other site
1321369000017	beta-clamp/translesion DNA polymerase binding surface; other site
1321369000018	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1321369000019	recF protein; Region: recf; TIGR00611
1321369000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1321369000021	Walker A/P-loop; other site
1321369000022	ATP binding site [chemical binding]; other site
1321369000023	Q-loop/lid; other site
1321369000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369000025	ABC transporter signature motif; other site
1321369000026	Walker B; other site
1321369000027	D-loop; other site
1321369000028	H-loop/switch region; other site
1321369000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1321369000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369000031	Mg2+ binding site [ion binding]; other site
1321369000032	G-X-G motif; other site
1321369000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1321369000034	anchoring element; other site
1321369000035	dimer interface [polypeptide binding]; other site
1321369000036	ATP binding site [chemical binding]; other site
1321369000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1321369000038	active site
1321369000039	putative metal-binding site [ion binding]; other site
1321369000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1321369000041	DNA gyrase subunit A; Validated; Region: PRK05560
1321369000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1321369000043	CAP-like domain; other site
1321369000044	active site
1321369000045	primary dimer interface [polypeptide binding]; other site
1321369000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369000052	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1321369000053	putative substrate binding site [chemical binding]; other site
1321369000054	putative ATP binding site [chemical binding]; other site
1321369000055	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1321369000056	active sites [active]
1321369000057	tetramer interface [polypeptide binding]; other site
1321369000058	seryl-tRNA synthetase; Provisional; Region: PRK05431
1321369000059	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1321369000060	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1321369000061	dimer interface [polypeptide binding]; other site
1321369000062	active site
1321369000063	motif 1; other site
1321369000064	motif 2; other site
1321369000065	motif 3; other site
1321369000066	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1321369000067	Predicted membrane protein [Function unknown]; Region: COG4392
1321369000068	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1321369000069	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1321369000070	Predicted membrane protein [Function unknown]; Region: COG4241
1321369000071	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1321369000072	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1321369000073	DHH family; Region: DHH; pfam01368
1321369000074	DHHA1 domain; Region: DHHA1; pfam02272
1321369000075	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1321369000076	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1321369000077	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1321369000078	replicative DNA helicase; Region: DnaB; TIGR00665
1321369000079	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1321369000080	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1321369000081	Walker A motif; other site
1321369000082	ATP binding site [chemical binding]; other site
1321369000083	Walker B motif; other site
1321369000084	DNA binding loops [nucleotide binding]
1321369000085	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1321369000086	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1321369000087	GDP-binding site [chemical binding]; other site
1321369000088	ACT binding site; other site
1321369000089	IMP binding site; other site
1321369000090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369000091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369000092	active site
1321369000093	phosphorylation site [posttranslational modification]
1321369000094	intermolecular recognition site; other site
1321369000095	dimerization interface [polypeptide binding]; other site
1321369000096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369000097	DNA binding site [nucleotide binding]
1321369000098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1321369000099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1321369000100	dimerization interface [polypeptide binding]; other site
1321369000101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1321369000102	putative active site [active]
1321369000103	heme pocket [chemical binding]; other site
1321369000104	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369000105	dimer interface [polypeptide binding]; other site
1321369000106	phosphorylation site [posttranslational modification]
1321369000107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369000108	ATP binding site [chemical binding]; other site
1321369000109	Mg2+ binding site [ion binding]; other site
1321369000110	G-X-G motif; other site
1321369000111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1321369000112	YycH protein; Region: YycH; pfam07435
1321369000113	YycH protein; Region: YycI; cl02015
1321369000114	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1321369000115	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1321369000116	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1321369000117	putative active site [active]
1321369000118	putative metal binding site [ion binding]; other site
1321369000119	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1321369000120	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1321369000121	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1321369000122	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
1321369000123	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
1321369000124	GIY-YIG motif/motif A; other site
1321369000125	putative active site [active]
1321369000126	putative metal binding site [ion binding]; other site
1321369000127	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
1321369000128	active site
1321369000129	DNA binding site [nucleotide binding]
1321369000130	catalytic site [active]
1321369000131	Phage associated DNA primase [General function prediction only]; Region: COG3378
1321369000132	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1321369000133	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1321369000134	catalytic residues [active]
1321369000135	catalytic nucleophile [active]
1321369000136	Recombinase; Region: Recombinase; pfam07508
1321369000137	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1321369000138	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
1321369000139	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1321369000140	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1321369000141	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
1321369000142	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1321369000143	MPN+ (JAMM) motif; other site
1321369000144	Zinc-binding site [ion binding]; other site
1321369000145	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1321369000146	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1321369000147	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1321369000148	Int/Topo IB signature motif; other site
1321369000149	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1321369000150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369000151	S-adenosylmethionine binding site [chemical binding]; other site
1321369000152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369000153	S-adenosylmethionine binding site [chemical binding]; other site
1321369000154	WYL domain; Region: WYL; pfam13280
1321369000155	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1321369000156	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1321369000157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1321369000158	Integrase core domain; Region: rve; pfam00665
1321369000159	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1321369000160	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369000161	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1321369000162	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
1321369000163	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
1321369000164	DNA binding residues [nucleotide binding]
1321369000165	dimer interface [polypeptide binding]; other site
1321369000166	mercury binding site [ion binding]; other site
1321369000167	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1321369000168	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1321369000169	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1321369000170	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1321369000171	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1321369000172	metal-binding site [ion binding]
1321369000173	mercuric reductase; Region: MerA; TIGR02053
1321369000174	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369000175	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1321369000176	alkylmercury lyase; Provisional; Region: PRK13239
1321369000177	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
1321369000178	Alkylmercury lyase; Region: MerB; pfam03243
1321369000179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1321369000180	Integrase core domain; Region: rve; pfam00665
1321369000181	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
1321369000182	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1321369000183	active site
1321369000184	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1321369000185	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1321369000186	putative active site [active]
1321369000187	catalytic site [active]
1321369000188	putative metal binding site [ion binding]; other site
1321369000189	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1321369000190	putative active site [active]
1321369000191	putative catalytic site [active]
1321369000192	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1321369000193	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1321369000194	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1321369000195	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1321369000196	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1321369000197	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1321369000198	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369000199	MarR family; Region: MarR_2; pfam12802
1321369000200	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1321369000201	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1321369000202	nucleotide binding site [chemical binding]; other site
1321369000203	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1321369000204	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1321369000205	active site residue [active]
1321369000206	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1321369000207	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1321369000208	active site residue [active]
1321369000209	SirA_RHOD_Pry_redox.    SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420
1321369000210	CPxP  motif; other site
1321369000211	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1321369000212	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1321369000213	putative homodimer interface [polypeptide binding]; other site
1321369000214	putative homotetramer interface [polypeptide binding]; other site
1321369000215	putative metal binding site [ion binding]; other site
1321369000216	putative homodimer-homodimer interface [polypeptide binding]; other site
1321369000217	putative allosteric switch controlling residues; other site
1321369000218	cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779
1321369000219	Cadmium resistance transporter; Region: Cad; pfam03596
1321369000220	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1321369000221	metal-binding site [ion binding]
1321369000222	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1321369000223	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1321369000224	metal-binding site [ion binding]
1321369000225	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1321369000226	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1321369000227	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1321369000228	dimerization interface [polypeptide binding]; other site
1321369000229	putative DNA binding site [nucleotide binding]; other site
1321369000230	putative Zn2+ binding site [ion binding]; other site
1321369000231	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1321369000232	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1321369000233	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1321369000234	active site
1321369000235	DNA binding site [nucleotide binding]
1321369000236	Int/Topo IB signature motif; other site
1321369000237	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1321369000238	MPN+ (JAMM) motif; other site
1321369000239	Zinc-binding site [ion binding]; other site
1321369000240	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1321369000241	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1321369000242	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
1321369000243	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1321369000244	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1321369000245	catalytic residues [active]
1321369000246	catalytic nucleophile [active]
1321369000247	Presynaptic Site I dimer interface [polypeptide binding]; other site
1321369000248	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1321369000249	Synaptic Flat tetramer interface [polypeptide binding]; other site
1321369000250	Synaptic Site I dimer interface [polypeptide binding]; other site
1321369000251	DNA binding site [nucleotide binding]
1321369000252	Recombinase; Region: Recombinase; pfam07508
1321369000253	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1321369000254	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1321369000255	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1321369000256	catalytic residues [active]
1321369000257	catalytic nucleophile [active]
1321369000258	Recombinase; Region: Recombinase; pfam07508
1321369000259	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1321369000260	Domain of unknown function (DUF927); Region: DUF927; pfam06048
1321369000261	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1321369000262	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
1321369000263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369000264	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1321369000265	Walker A motif; other site
1321369000266	ATP binding site [chemical binding]; other site
1321369000267	Walker B motif; other site
1321369000268	arginine finger; other site
1321369000269	5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736
1321369000270	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1321369000271	active site
1321369000272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369000274	putative substrate translocation pore; other site
1321369000275	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369000276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1321369000277	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369000278	Coenzyme A binding pocket [chemical binding]; other site
1321369000279	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1321369000280	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1321369000281	FMN binding site [chemical binding]; other site
1321369000282	active site
1321369000283	catalytic residues [active]
1321369000284	substrate binding site [chemical binding]; other site
1321369000285	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
1321369000286	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1321369000287	Part of AAA domain; Region: AAA_19; pfam13245
1321369000288	AAA domain; Region: AAA_12; pfam13087
1321369000289	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1321369000290	active site
1321369000291	catalytic site [active]
1321369000292	putative metal binding site [ion binding]; other site
1321369000293	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369000294	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1321369000295	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1321369000296	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1321369000297	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1321369000298	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1321369000299	metal binding site [ion binding]; metal-binding site
1321369000300	dimer interface [polypeptide binding]; other site
1321369000301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000302	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369000303	putative substrate translocation pore; other site
1321369000304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000305	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1321369000306	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1321369000307	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1321369000308	PhoU domain; Region: PhoU; pfam01895
1321369000309	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
1321369000310	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1321369000311	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1321369000312	L-lactate permease; Region: Lactate_perm; cl00701
1321369000313	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369000314	B domain; Region: B; pfam02216
1321369000315	B domain; Region: B; pfam02216
1321369000316	B domain; Region: B; pfam02216
1321369000317	B domain; Region: B; pfam02216
1321369000318	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369000319	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369000320	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369000321	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369000322	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369000323	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1321369000324	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369000325	ABC-ATPase subunit  interface; other site
1321369000326	dimer interface [polypeptide binding]; other site
1321369000327	putative PBP binding regions; other site
1321369000328	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1321369000329	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369000330	ABC-ATPase subunit  interface; other site
1321369000331	dimer interface [polypeptide binding]; other site
1321369000332	putative PBP binding regions; other site
1321369000333	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1321369000334	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1321369000335	siderophore binding site; other site
1321369000336	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1321369000337	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1321369000338	dimer interface [polypeptide binding]; other site
1321369000339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369000340	catalytic residue [active]
1321369000341	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1321369000342	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1321369000343	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1321369000344	IucA / IucC family; Region: IucA_IucC; pfam04183
1321369000345	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1321369000346	drug efflux system protein MdtG; Provisional; Region: PRK09874
1321369000347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000348	putative substrate translocation pore; other site
1321369000349	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1321369000350	IucA / IucC family; Region: IucA_IucC; pfam04183
1321369000351	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1321369000352	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1321369000353	IucA / IucC family; Region: IucA_IucC; pfam04183
1321369000354	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1321369000355	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1321369000356	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1321369000357	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
1321369000358	dimer interface [polypeptide binding]; other site
1321369000359	active site
1321369000360	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1321369000361	catalytic residues [active]
1321369000362	substrate binding site [chemical binding]; other site
1321369000363	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1321369000364	ParB-like nuclease domain; Region: ParBc; pfam02195
1321369000365	acetoin reductase; Validated; Region: PRK08643
1321369000366	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1321369000367	NAD binding site [chemical binding]; other site
1321369000368	homotetramer interface [polypeptide binding]; other site
1321369000369	homodimer interface [polypeptide binding]; other site
1321369000370	active site
1321369000371	substrate binding site [chemical binding]; other site
1321369000372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369000373	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1321369000374	NAD(P) binding site [chemical binding]; other site
1321369000375	active site
1321369000376	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1321369000377	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1321369000378	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1321369000379	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1321369000380	putative ADP-binding pocket [chemical binding]; other site
1321369000381	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1321369000382	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1321369000383	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1321369000384	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1321369000385	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1321369000386	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1321369000387	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1321369000388	DNA-binding site [nucleotide binding]; DNA binding site
1321369000389	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1321369000390	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1321369000391	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369000392	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1321369000393	intersubunit interface [polypeptide binding]; other site
1321369000394	active site
1321369000395	catalytic residue [active]
1321369000396	phosphopentomutase; Provisional; Region: PRK05362
1321369000397	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1321369000398	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1321369000399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369000400	dimer interface [polypeptide binding]; other site
1321369000401	conserved gate region; other site
1321369000402	putative PBP binding loops; other site
1321369000403	ABC-ATPase subunit interface; other site
1321369000404	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1321369000405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369000406	dimer interface [polypeptide binding]; other site
1321369000407	conserved gate region; other site
1321369000408	ABC-ATPase subunit interface; other site
1321369000409	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1321369000410	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1321369000411	Walker A/P-loop; other site
1321369000412	ATP binding site [chemical binding]; other site
1321369000413	Q-loop/lid; other site
1321369000414	ABC transporter signature motif; other site
1321369000415	Walker B; other site
1321369000416	D-loop; other site
1321369000417	H-loop/switch region; other site
1321369000418	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1321369000419	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1321369000420	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1321369000421	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1321369000422	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1321369000423	active site
1321369000424	metal binding site [ion binding]; metal-binding site
1321369000425	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1321369000426	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369000427	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369000428	non-specific DNA binding site [nucleotide binding]; other site
1321369000429	salt bridge; other site
1321369000430	sequence-specific DNA binding site [nucleotide binding]; other site
1321369000431	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1321369000432	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1321369000433	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1321369000434	putative catalytic cysteine [active]
1321369000435	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1321369000436	putative active site [active]
1321369000437	metal binding site [ion binding]; metal-binding site
1321369000438	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1321369000439	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1321369000440	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1321369000441	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1321369000442	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1321369000443	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1321369000444	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1321369000445	NAD(P) binding site [chemical binding]; other site
1321369000446	homodimer interface [polypeptide binding]; other site
1321369000447	substrate binding site [chemical binding]; other site
1321369000448	active site
1321369000449	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
1321369000450	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1321369000451	NAD(P) binding site [chemical binding]; other site
1321369000452	homodimer interface [polypeptide binding]; other site
1321369000453	substrate binding site [chemical binding]; other site
1321369000454	active site
1321369000455	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
1321369000456	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
1321369000457	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1321369000458	putative NAD(P) binding site [chemical binding]; other site
1321369000459	active site
1321369000460	putative substrate binding site [chemical binding]; other site
1321369000461	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1321369000462	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1321369000463	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1321369000464	active site
1321369000465	homodimer interface [polypeptide binding]; other site
1321369000466	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1321369000467	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1321369000468	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1321369000469	trimer interface [polypeptide binding]; other site
1321369000470	active site
1321369000471	substrate binding site [chemical binding]; other site
1321369000472	CoA binding site [chemical binding]; other site
1321369000473	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1321369000474	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1321369000475	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1321369000476	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1321369000477	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1321369000478	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1321369000479	putative NAD(P) binding site [chemical binding]; other site
1321369000480	active site
1321369000481	putative substrate binding site [chemical binding]; other site
1321369000482	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1321369000483	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1321369000484	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1321369000485	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1321369000486	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1321369000487	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1321369000488	active site
1321369000489	homodimer interface [polypeptide binding]; other site
1321369000490	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
1321369000491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1321369000492	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1321369000493	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1321369000494	NAD(P) binding site [chemical binding]; other site
1321369000495	catalytic residues [active]
1321369000496	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1321369000497	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1321369000498	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
1321369000499	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1321369000500	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1321369000501	Walker A/P-loop; other site
1321369000502	ATP binding site [chemical binding]; other site
1321369000503	Q-loop/lid; other site
1321369000504	ABC transporter signature motif; other site
1321369000505	Walker B; other site
1321369000506	D-loop; other site
1321369000507	H-loop/switch region; other site
1321369000508	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1321369000509	NMT1-like family; Region: NMT1_2; pfam13379
1321369000510	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1321369000511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1321369000512	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1321369000513	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1321369000514	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1321369000515	formate dehydrogenase; Provisional; Region: PRK07574
1321369000516	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1321369000517	dimerization interface [polypeptide binding]; other site
1321369000518	ligand binding site [chemical binding]; other site
1321369000519	NAD binding site [chemical binding]; other site
1321369000520	catalytic site [active]
1321369000521	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1321369000522	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1321369000523	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1321369000524	acyl-activating enzyme (AAE) consensus motif; other site
1321369000525	AMP binding site [chemical binding]; other site
1321369000526	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1321369000527	Condensation domain; Region: Condensation; pfam00668
1321369000528	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1321369000529	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1321369000530	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1321369000531	acyl-activating enzyme (AAE) consensus motif; other site
1321369000532	AMP binding site [chemical binding]; other site
1321369000533	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1321369000534	thioester reductase domain; Region: Thioester-redct; TIGR01746
1321369000535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369000536	NAD(P) binding site [chemical binding]; other site
1321369000537	active site
1321369000538	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1321369000539	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1321369000540	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
1321369000541	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1321369000542	nucleotide binding site [chemical binding]; other site
1321369000543	N-acetyl-L-glutamate binding site [chemical binding]; other site
1321369000544	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1321369000545	heterotetramer interface [polypeptide binding]; other site
1321369000546	active site pocket [active]
1321369000547	cleavage site
1321369000548	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1321369000549	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1321369000550	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1321369000551	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1321369000552	inhibitor-cofactor binding pocket; inhibition site
1321369000553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369000554	catalytic residue [active]
1321369000555	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1321369000556	Isochorismatase family; Region: Isochorismatase; pfam00857
1321369000557	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1321369000558	catalytic triad [active]
1321369000559	conserved cis-peptide bond; other site
1321369000560	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1321369000561	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1321369000562	dimer interface [polypeptide binding]; other site
1321369000563	PYR/PP interface [polypeptide binding]; other site
1321369000564	TPP binding site [chemical binding]; other site
1321369000565	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1321369000566	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1321369000567	TPP-binding site [chemical binding]; other site
1321369000568	dimer interface [polypeptide binding]; other site
1321369000569	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369000570	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1321369000571	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369000572	active site turn [active]
1321369000573	phosphorylation site [posttranslational modification]
1321369000574	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1321369000575	HPr interaction site; other site
1321369000576	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1321369000577	active site
1321369000578	phosphorylation site [posttranslational modification]
1321369000579	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1321369000580	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1321369000581	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
1321369000582	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1321369000583	putative active site [active]
1321369000584	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1321369000585	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369000586	active site turn [active]
1321369000587	phosphorylation site [posttranslational modification]
1321369000588	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369000589	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1321369000590	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1321369000591	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1321369000592	putative active site [active]
1321369000593	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1321369000594	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1321369000595	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369000596	ATP binding site [chemical binding]; other site
1321369000597	putative Mg++ binding site [ion binding]; other site
1321369000598	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1321369000599	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369000600	Walker A/P-loop; other site
1321369000601	ATP binding site [chemical binding]; other site
1321369000602	Q-loop/lid; other site
1321369000603	ABC transporter signature motif; other site
1321369000604	Walker B; other site
1321369000605	D-loop; other site
1321369000606	H-loop/switch region; other site
1321369000607	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1321369000608	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369000609	Walker A/P-loop; other site
1321369000610	ATP binding site [chemical binding]; other site
1321369000611	Q-loop/lid; other site
1321369000612	ABC transporter signature motif; other site
1321369000613	Walker B; other site
1321369000614	D-loop; other site
1321369000615	H-loop/switch region; other site
1321369000616	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1321369000617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369000618	dimer interface [polypeptide binding]; other site
1321369000619	conserved gate region; other site
1321369000620	putative PBP binding loops; other site
1321369000621	ABC-ATPase subunit interface; other site
1321369000622	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1321369000623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369000624	dimer interface [polypeptide binding]; other site
1321369000625	conserved gate region; other site
1321369000626	ABC-ATPase subunit interface; other site
1321369000627	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1321369000628	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1321369000629	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1321369000630	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1321369000631	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1321369000632	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369000633	MULE transposase domain; Region: MULE; pfam10551
1321369000634	azoreductase; Reviewed; Region: PRK00170
1321369000635	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1321369000636	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1321369000637	Peptidase family M23; Region: Peptidase_M23; pfam01551
1321369000638	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1321369000639	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1321369000640	Walker A/P-loop; other site
1321369000641	ATP binding site [chemical binding]; other site
1321369000642	Q-loop/lid; other site
1321369000643	ABC transporter signature motif; other site
1321369000644	Walker B; other site
1321369000645	D-loop; other site
1321369000646	H-loop/switch region; other site
1321369000647	TOBE domain; Region: TOBE; pfam03459
1321369000648	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1321369000649	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1321369000650	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1321369000651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369000652	dimer interface [polypeptide binding]; other site
1321369000653	conserved gate region; other site
1321369000654	putative PBP binding loops; other site
1321369000655	ABC-ATPase subunit interface; other site
1321369000656	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1321369000657	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1321369000658	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1321369000659	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1321369000660	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1321369000661	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1321369000662	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1321369000663	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1321369000664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1321369000665	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1321369000666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000667	putative substrate translocation pore; other site
1321369000668	Response regulator receiver domain; Region: Response_reg; pfam00072
1321369000669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369000670	active site
1321369000671	phosphorylation site [posttranslational modification]
1321369000672	intermolecular recognition site; other site
1321369000673	dimerization interface [polypeptide binding]; other site
1321369000674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1321369000675	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1321369000676	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1321369000677	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1321369000678	Histidine kinase; Region: His_kinase; pfam06580
1321369000679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369000680	ATP binding site [chemical binding]; other site
1321369000681	Mg2+ binding site [ion binding]; other site
1321369000682	G-X-G motif; other site
1321369000683	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1321369000684	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1321369000685	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1321369000686	Pyruvate formate lyase 1; Region: PFL1; cd01678
1321369000687	coenzyme A binding site [chemical binding]; other site
1321369000688	active site
1321369000689	catalytic residues [active]
1321369000690	glycine loop; other site
1321369000691	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1321369000692	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369000693	FeS/SAM binding site; other site
1321369000694	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1321369000695	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
1321369000696	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1321369000697	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1321369000698	putative active site [active]
1321369000699	catalytic site [active]
1321369000700	putative metal binding site [ion binding]; other site
1321369000701	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1321369000702	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1321369000703	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1321369000704	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1321369000705	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1321369000706	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1321369000707	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1321369000708	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1321369000709	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1321369000710	dimer interface [polypeptide binding]; other site
1321369000711	active site
1321369000712	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1321369000713	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1321369000714	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1321369000715	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1321369000716	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1321369000717	substrate binding site [chemical binding]; other site
1321369000718	oxyanion hole (OAH) forming residues; other site
1321369000719	trimer interface [polypeptide binding]; other site
1321369000720	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1321369000721	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1321369000722	active site
1321369000723	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1321369000724	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1321369000725	acyl-activating enzyme (AAE) consensus motif; other site
1321369000726	AMP binding site [chemical binding]; other site
1321369000727	active site
1321369000728	CoA binding site [chemical binding]; other site
1321369000729	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1321369000730	Coenzyme A transferase; Region: CoA_trans; smart00882
1321369000731	Coenzyme A transferase; Region: CoA_trans; cl17247
1321369000732	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1321369000733	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1321369000734	catalytic triad [active]
1321369000735	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1321369000736	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1321369000737	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1321369000738	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1321369000739	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1321369000740	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1321369000741	heme-binding site [chemical binding]; other site
1321369000742	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1321369000743	FAD binding pocket [chemical binding]; other site
1321369000744	FAD binding motif [chemical binding]; other site
1321369000745	phosphate binding motif [ion binding]; other site
1321369000746	beta-alpha-beta structure motif; other site
1321369000747	NAD binding pocket [chemical binding]; other site
1321369000748	Heme binding  pocket [chemical binding]; other site
1321369000749	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1321369000750	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1321369000751	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369000752	NAD binding site [chemical binding]; other site
1321369000753	dimer interface [polypeptide binding]; other site
1321369000754	substrate binding site [chemical binding]; other site
1321369000755	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1321369000756	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369000757	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369000758	active site turn [active]
1321369000759	phosphorylation site [posttranslational modification]
1321369000760	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1321369000761	active site
1321369000762	tetramer interface [polypeptide binding]; other site
1321369000763	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1321369000764	Mga helix-turn-helix domain; Region: Mga; pfam05043
1321369000765	PRD domain; Region: PRD; pfam00874
1321369000766	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1321369000767	active site
1321369000768	P-loop; other site
1321369000769	phosphorylation site [posttranslational modification]
1321369000770	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369000771	active site
1321369000772	phosphorylation site [posttranslational modification]
1321369000773	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369000774	active site
1321369000775	phosphorylation site [posttranslational modification]
1321369000776	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1321369000777	active site
1321369000778	P-loop; other site
1321369000779	phosphorylation site [posttranslational modification]
1321369000780	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1321369000781	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1321369000782	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1321369000783	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1321369000784	putative NAD(P) binding site [chemical binding]; other site
1321369000785	catalytic Zn binding site [ion binding]; other site
1321369000786	structural Zn binding site [ion binding]; other site
1321369000787	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1321369000788	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1321369000789	putative NAD(P) binding site [chemical binding]; other site
1321369000790	catalytic Zn binding site [ion binding]; other site
1321369000791	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1321369000792	substrate binding site; other site
1321369000793	dimer interface; other site
1321369000794	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1321369000795	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1321369000796	putative NAD(P) binding site [chemical binding]; other site
1321369000797	putative catalytic Zn binding site [ion binding]; other site
1321369000798	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1321369000799	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1321369000800	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1321369000801	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1321369000802	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1321369000803	substrate binding site; other site
1321369000804	dimer interface; other site
1321369000805	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1321369000806	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1321369000807	putative NAD(P) binding site [chemical binding]; other site
1321369000808	putative catalytic Zn binding site [ion binding]; other site
1321369000809	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1321369000810	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1321369000811	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1321369000812	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1321369000813	active site
1321369000814	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
1321369000815	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1321369000816	Hemerythrin-like domain; Region: Hr-like; cd12108
1321369000817	Fe binding site [ion binding]; other site
1321369000818	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1321369000819	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1321369000820	Histidine kinase; Region: His_kinase; pfam06580
1321369000821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369000822	Mg2+ binding site [ion binding]; other site
1321369000823	G-X-G motif; other site
1321369000824	two-component response regulator; Provisional; Region: PRK14084
1321369000825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369000826	active site
1321369000827	phosphorylation site [posttranslational modification]
1321369000828	intermolecular recognition site; other site
1321369000829	dimerization interface [polypeptide binding]; other site
1321369000830	LytTr DNA-binding domain; Region: LytTR; pfam04397
1321369000831	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1321369000832	antiholin-like protein LrgB; Provisional; Region: PRK04288
1321369000833	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1321369000834	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1321369000835	DNA-binding site [nucleotide binding]; DNA binding site
1321369000836	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1321369000837	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1321369000838	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1321369000839	HPr interaction site; other site
1321369000840	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1321369000841	active site
1321369000842	phosphorylation site [posttranslational modification]
1321369000843	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1321369000844	beta-galactosidase; Region: BGL; TIGR03356
1321369000845	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1321369000846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369000847	S-adenosylmethionine binding site [chemical binding]; other site
1321369000848	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1321369000849	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1321369000850	substrate binding site [chemical binding]; other site
1321369000851	dimer interface [polypeptide binding]; other site
1321369000852	ATP binding site [chemical binding]; other site
1321369000853	D-ribose pyranase; Provisional; Region: PRK11797
1321369000854	Sugar transport protein; Region: Sugar_transport; pfam06800
1321369000855	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1321369000856	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1321369000857	DNA binding site [nucleotide binding]
1321369000858	domain linker motif; other site
1321369000859	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1321369000860	dimerization interface [polypeptide binding]; other site
1321369000861	ligand binding site [chemical binding]; other site
1321369000862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369000864	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1321369000865	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1321369000866	active site
1321369000867	Surface antigen [General function prediction only]; Region: COG3942
1321369000868	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1321369000869	Peptidase family M23; Region: Peptidase_M23; pfam01551
1321369000870	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1321369000871	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1321369000872	Walker A/P-loop; other site
1321369000873	ATP binding site [chemical binding]; other site
1321369000874	Q-loop/lid; other site
1321369000875	ABC transporter signature motif; other site
1321369000876	Walker B; other site
1321369000877	D-loop; other site
1321369000878	H-loop/switch region; other site
1321369000879	Surface antigen [General function prediction only]; Region: COG3942
1321369000880	CHAP domain; Region: CHAP; pfam05257
1321369000881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1321369000882	Predicted membrane protein [Function unknown]; Region: COG1511
1321369000883	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1321369000884	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1321369000885	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
1321369000886	Uncharacterized small protein [Function unknown]; Region: COG5417
1321369000887	Predicted membrane protein [Function unknown]; Region: COG4499
1321369000888	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1321369000889	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1321369000890	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1321369000891	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1321369000892	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1321369000893	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
1321369000894	LXG domain of WXG superfamily; Region: LXG; pfam04740
1321369000895	Protein of unknown function, DUF600; Region: DUF600; cl04640
1321369000896	Protein of unknown function, DUF600; Region: DUF600; cl04640
1321369000897	Protein of unknown function, DUF600; Region: DUF600; cl04640
1321369000898	Protein of unknown function, DUF600; Region: DUF600; cl04640
1321369000899	Protein of unknown function, DUF600; Region: DUF600; cl04640
1321369000900	Protein of unknown function, DUF600; Region: DUF600; cl04640
1321369000901	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1321369000902	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1321369000903	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1321369000904	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1321369000905	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1321369000906	FtsX-like permease family; Region: FtsX; pfam02687
1321369000907	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1321369000908	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1321369000909	Walker A/P-loop; other site
1321369000910	ATP binding site [chemical binding]; other site
1321369000911	Q-loop/lid; other site
1321369000912	ABC transporter signature motif; other site
1321369000913	Walker B; other site
1321369000914	D-loop; other site
1321369000915	H-loop/switch region; other site
1321369000916	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1321369000917	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1321369000918	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369000919	non-specific DNA binding site [nucleotide binding]; other site
1321369000920	salt bridge; other site
1321369000921	sequence-specific DNA binding site [nucleotide binding]; other site
1321369000922	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1321369000923	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1321369000924	substrate binding site [chemical binding]; other site
1321369000925	ATP binding site [chemical binding]; other site
1321369000926	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1321369000927	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1321369000928	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1321369000929	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1321369000930	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1321369000931	putative transporter; Provisional; Region: PRK10484
1321369000932	Na binding site [ion binding]; other site
1321369000933	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1321369000934	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1321369000935	inhibitor site; inhibition site
1321369000936	active site
1321369000937	dimer interface [polypeptide binding]; other site
1321369000938	catalytic residue [active]
1321369000939	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1321369000940	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1321369000941	nucleotide binding site [chemical binding]; other site
1321369000942	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1321369000943	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1321369000944	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1321369000945	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1321369000946	putative active site [active]
1321369000947	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1321369000948	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1321369000949	putative active site cavity [active]
1321369000950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1321369000951	Nucleoside recognition; Region: Gate; pfam07670
1321369000952	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1321369000953	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1321369000954	PGAP1-like protein; Region: PGAP1; pfam07819
1321369000955	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1321369000956	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1321369000957	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1321369000958	putative active site [active]
1321369000959	putative FMN binding site [chemical binding]; other site
1321369000960	putative substrate binding site [chemical binding]; other site
1321369000961	putative catalytic residue [active]
1321369000962	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1321369000963	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1321369000964	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1321369000965	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1321369000966	lipoyl attachment site [posttranslational modification]; other site
1321369000967	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1321369000968	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1321369000969	putative ADP-ribose binding site [chemical binding]; other site
1321369000970	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1321369000971	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1321369000972	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1321369000973	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1321369000974	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1321369000975	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1321369000976	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1321369000977	NADP binding site [chemical binding]; other site
1321369000978	putative substrate binding site [chemical binding]; other site
1321369000979	active site
1321369000980	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1321369000981	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1321369000982	active site
1321369000983	P-loop; other site
1321369000984	phosphorylation site [posttranslational modification]
1321369000985	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369000986	active site
1321369000987	phosphorylation site [posttranslational modification]
1321369000988	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1321369000989	HTH domain; Region: HTH_11; pfam08279
1321369000990	HTH domain; Region: HTH_11; pfam08279
1321369000991	PRD domain; Region: PRD; pfam00874
1321369000992	PRD domain; Region: PRD; pfam00874
1321369000993	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1321369000994	active site
1321369000995	P-loop; other site
1321369000996	phosphorylation site [posttranslational modification]
1321369000997	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369000998	active site
1321369000999	phosphorylation site [posttranslational modification]
1321369001000	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369001001	MarR family; Region: MarR_2; pfam12802
1321369001002	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1321369001003	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1321369001004	MepB protein; Region: MepB; cl01985
1321369001005	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1321369001006	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1321369001007	Zn binding site [ion binding]; other site
1321369001008	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1321369001009	Zn binding site [ion binding]; other site
1321369001010	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1321369001011	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1321369001012	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1321369001013	Predicted flavoprotein [General function prediction only]; Region: COG0431
1321369001014	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1321369001015	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
1321369001016	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1321369001017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369001018	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1321369001019	Imelysin; Region: Peptidase_M75; pfam09375
1321369001020	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1321369001021	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1321369001022	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1321369001023	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1321369001024	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1321369001025	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
1321369001026	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1321369001027	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1321369001028	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1321369001029	Walker A/P-loop; other site
1321369001030	ATP binding site [chemical binding]; other site
1321369001031	Q-loop/lid; other site
1321369001032	ABC transporter signature motif; other site
1321369001033	Walker B; other site
1321369001034	D-loop; other site
1321369001035	H-loop/switch region; other site
1321369001036	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
1321369001037	Helix-turn-helix domain; Region: HTH_28; pfam13518
1321369001038	Winged helix-turn helix; Region: HTH_29; pfam13551
1321369001039	Integrase core domain; Region: rve; pfam00665
1321369001040	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1321369001041	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1321369001042	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1321369001043	catalytic residues [active]
1321369001044	catalytic nucleophile [active]
1321369001045	Presynaptic Site I dimer interface [polypeptide binding]; other site
1321369001046	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1321369001047	Synaptic Flat tetramer interface [polypeptide binding]; other site
1321369001048	Synaptic Site I dimer interface [polypeptide binding]; other site
1321369001049	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1321369001050	DNA-binding interface [nucleotide binding]; DNA binding site
1321369001051	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369001052	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1321369001053	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1321369001054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369001055	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369001056	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369001057	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1321369001058	RibD C-terminal domain; Region: RibD_C; cl17279
1321369001059	WYL domain; Region: WYL; pfam13280
1321369001060	Predicted transcriptional regulator [Transcription]; Region: COG2378
1321369001061	HTH domain; Region: HTH_11; pfam08279
1321369001062	WYL domain; Region: WYL; pfam13280
1321369001063	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1321369001064	active site
1321369001065	ATP binding site [chemical binding]; other site
1321369001066	Phosphotransferase enzyme family; Region: APH; pfam01636
1321369001067	antibiotic binding site [chemical binding]; other site
1321369001068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369001069	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369001070	Coenzyme A binding pocket [chemical binding]; other site
1321369001071	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1321369001072	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1321369001073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369001074	S-adenosylmethionine binding site [chemical binding]; other site
1321369001075	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1321369001076	active site
1321369001077	NTP binding site [chemical binding]; other site
1321369001078	metal binding triad [ion binding]; metal-binding site
1321369001079	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1321369001080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369001081	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369001082	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369001083	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1321369001084	Predicted membrane protein [Function unknown]; Region: COG4292
1321369001085	putative acyltransferase; Provisional; Region: PRK05790
1321369001086	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1321369001087	dimer interface [polypeptide binding]; other site
1321369001088	active site
1321369001089	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1321369001090	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1321369001091	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
1321369001092	THF binding site; other site
1321369001093	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1321369001094	substrate binding site [chemical binding]; other site
1321369001095	THF binding site; other site
1321369001096	zinc-binding site [ion binding]; other site
1321369001097	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1321369001098	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1321369001099	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1321369001100	FAD binding site [chemical binding]; other site
1321369001101	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1321369001102	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1321369001103	homodimer interface [polypeptide binding]; other site
1321369001104	substrate-cofactor binding pocket; other site
1321369001105	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369001106	catalytic residue [active]
1321369001107	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1321369001108	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1321369001109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369001110	catalytic residue [active]
1321369001111	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1321369001112	ParB-like nuclease domain; Region: ParB; smart00470
1321369001113	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1321369001114	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1321369001115	GTP-binding protein YchF; Reviewed; Region: PRK09601
1321369001116	YchF GTPase; Region: YchF; cd01900
1321369001117	G1 box; other site
1321369001118	GTP/Mg2+ binding site [chemical binding]; other site
1321369001119	Switch I region; other site
1321369001120	G2 box; other site
1321369001121	Switch II region; other site
1321369001122	G3 box; other site
1321369001123	G4 box; other site
1321369001124	G5 box; other site
1321369001125	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1321369001126	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1321369001127	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1321369001128	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1321369001129	dimer interface [polypeptide binding]; other site
1321369001130	ssDNA binding site [nucleotide binding]; other site
1321369001131	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369001132	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1321369001133	Abi-like protein; Region: Abi_2; pfam07751
1321369001134	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1321369001135	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1321369001137	Predicted membrane protein [Function unknown]; Region: COG3212
1321369001138	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1321369001139	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1321369001140	non-specific DNA binding site [nucleotide binding]; other site
1321369001141	salt bridge; other site
1321369001142	sequence-specific DNA binding site [nucleotide binding]; other site
1321369001143	Predicted membrane protein [Function unknown]; Region: COG2261
1321369001144	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1321369001145	catalytic core [active]
1321369001146	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1321369001147	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1321369001148	catalytic residue [active]
1321369001149	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1321369001150	catalytic residues [active]
1321369001151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369001152	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369001153	peroxiredoxin; Region: AhpC; TIGR03137
1321369001154	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1321369001155	dimer interface [polypeptide binding]; other site
1321369001156	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1321369001157	catalytic triad [active]
1321369001158	peroxidatic and resolving cysteines [active]
1321369001159	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1321369001160	dimer interface [polypeptide binding]; other site
1321369001161	FMN binding site [chemical binding]; other site
1321369001162	NADPH bind site [chemical binding]; other site
1321369001163	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1321369001164	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1321369001165	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369001166	active site
1321369001167	xanthine permease; Region: pbuX; TIGR03173
1321369001168	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1321369001169	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1321369001170	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1321369001171	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1321369001172	active site
1321369001173	GMP synthase; Reviewed; Region: guaA; PRK00074
1321369001174	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1321369001175	AMP/PPi binding site [chemical binding]; other site
1321369001176	candidate oxyanion hole; other site
1321369001177	catalytic triad [active]
1321369001178	potential glutamine specificity residues [chemical binding]; other site
1321369001179	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1321369001180	ATP Binding subdomain [chemical binding]; other site
1321369001181	Ligand Binding sites [chemical binding]; other site
1321369001182	Dimerization subdomain; other site
1321369001183	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1321369001184	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1321369001185	Int/Topo IB signature motif; other site
1321369001186	Helix-turn-helix domain; Region: HTH_16; pfam12645
1321369001187	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1321369001188	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1321369001189	DNA binding residues [nucleotide binding]
1321369001190	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369001191	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369001192	non-specific DNA binding site [nucleotide binding]; other site
1321369001193	salt bridge; other site
1321369001194	sequence-specific DNA binding site [nucleotide binding]; other site
1321369001195	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1321369001196	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1321369001197	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1321369001198	catalytic residue [active]
1321369001199	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1321369001200	NlpC/P60 family; Region: NLPC_P60; pfam00877
1321369001201	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1321369001202	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369001203	AAA-like domain; Region: AAA_10; pfam12846
1321369001204	TcpE family; Region: TcpE; pfam12648
1321369001205	transposase/IS protein; Provisional; Region: PRK09183
1321369001206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369001207	Walker A motif; other site
1321369001208	ATP binding site [chemical binding]; other site
1321369001209	Walker B motif; other site
1321369001210	arginine finger; other site
1321369001211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1321369001212	Integrase core domain; Region: rve; pfam00665
1321369001213	Antirestriction protein (ArdA); Region: ArdA; pfam07275
1321369001214	Abortive infection C-terminus; Region: Abi_C; pfam14355
1321369001215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369001216	non-specific DNA binding site [nucleotide binding]; other site
1321369001217	salt bridge; other site
1321369001218	sequence-specific DNA binding site [nucleotide binding]; other site
1321369001219	Replication initiation factor; Region: Rep_trans; pfam02486
1321369001220	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1321369001221	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1321369001222	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1321369001223	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1321369001224	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1321369001225	Part of AAA domain; Region: AAA_19; pfam13245
1321369001226	Family description; Region: UvrD_C_2; pfam13538
1321369001227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369001228	AAA domain; Region: AAA_21; pfam13304
1321369001229	Walker A/P-loop; other site
1321369001230	ATP binding site [chemical binding]; other site
1321369001231	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1321369001232	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1321369001233	putative active site [active]
1321369001234	putative metal-binding site [ion binding]; other site
1321369001235	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369001236	MULE transposase domain; Region: MULE; pfam10551
1321369001237	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369001238	PemK-like protein; Region: PemK; pfam02452
1321369001239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1321369001240	Transposase; Region: HTH_Tnp_1; cl17663
1321369001241	Predicted membrane protein [Function unknown]; Region: COG3759
1321369001242	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1321369001243	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1321369001244	NADP binding site [chemical binding]; other site
1321369001245	superantigen-like protein; Reviewed; Region: PRK13037
1321369001246	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001247	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001248	superantigen-like protein; Reviewed; Region: PRK13041
1321369001249	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001250	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001251	superantigen-like protein; Reviewed; Region: PRK13335
1321369001252	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001253	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001254	superantigen-like protein; Reviewed; Region: PRK13042
1321369001255	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001256	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001257	superantigen-like protein 5; Reviewed; Region: PRK13035
1321369001258	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001259	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001260	superantigen-like protein; Reviewed; Region: PRK13040
1321369001261	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001262	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001263	superantigen-like protein 7; Reviewed; Region: PRK13346
1321369001264	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001265	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001266	superantigen-like protein; Reviewed; Region: PRK13039
1321369001267	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001268	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001269	superantigen-like protein; Reviewed; Region: PRK13345
1321369001270	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001271	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001272	superantigen-like protein 5; Reviewed; Region: PRK13035
1321369001273	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001274	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001275	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1321369001276	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1321369001277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369001278	S-adenosylmethionine binding site [chemical binding]; other site
1321369001279	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1321369001280	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1321369001281	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1321369001282	superantigen-like protein; Reviewed; Region: PRK13036
1321369001283	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1321369001284	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369001285	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369001286	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369001287	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369001288	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369001289	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369001290	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369001291	MULE transposase domain; Region: MULE; pfam10551
1321369001292	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369001293	MULE transposase domain; Region: MULE; pfam10551
1321369001294	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369001295	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1321369001296	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1321369001297	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1321369001298	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1321369001299	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1321369001300	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1321369001301	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1321369001302	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
1321369001303	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1321369001304	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1321369001305	active site
1321369001306	Esterase/lipase [General function prediction only]; Region: COG1647
1321369001307	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1321369001308	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1321369001309	Na2 binding site [ion binding]; other site
1321369001310	putative substrate binding site 1 [chemical binding]; other site
1321369001311	Na binding site 1 [ion binding]; other site
1321369001312	putative substrate binding site 2 [chemical binding]; other site
1321369001313	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1321369001314	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1321369001315	dimer interface [polypeptide binding]; other site
1321369001316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369001317	catalytic residue [active]
1321369001318	cystathionine beta-lyase; Provisional; Region: PRK07671
1321369001319	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1321369001320	homodimer interface [polypeptide binding]; other site
1321369001321	substrate-cofactor binding pocket; other site
1321369001322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369001323	catalytic residue [active]
1321369001324	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1321369001325	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1321369001326	Walker A/P-loop; other site
1321369001327	ATP binding site [chemical binding]; other site
1321369001328	Q-loop/lid; other site
1321369001329	ABC transporter signature motif; other site
1321369001330	Walker B; other site
1321369001331	D-loop; other site
1321369001332	H-loop/switch region; other site
1321369001333	NIL domain; Region: NIL; pfam09383
1321369001334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369001335	dimer interface [polypeptide binding]; other site
1321369001336	conserved gate region; other site
1321369001337	ABC-ATPase subunit interface; other site
1321369001338	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1321369001339	LysM domain; Region: LysM; pfam01476
1321369001340	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369001341	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369001342	Surface antigen [General function prediction only]; Region: COG3942
1321369001343	CHAP domain; Region: CHAP; pfam05257
1321369001344	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1321369001345	nudix motif; other site
1321369001346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369001347	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369001348	Coenzyme A binding pocket [chemical binding]; other site
1321369001349	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1321369001350	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1321369001351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1321369001352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1321369001353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1321369001354	dimerization interface [polypeptide binding]; other site
1321369001355	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1321369001356	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1321369001357	active site
1321369001358	dimer interface [polypeptide binding]; other site
1321369001359	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1321369001360	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1321369001361	active site
1321369001362	FMN binding site [chemical binding]; other site
1321369001363	substrate binding site [chemical binding]; other site
1321369001364	3Fe-4S cluster binding site [ion binding]; other site
1321369001365	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1321369001366	domain interface; other site
1321369001367	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1321369001368	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1321369001369	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369001370	active site turn [active]
1321369001371	phosphorylation site [posttranslational modification]
1321369001372	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369001373	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1321369001374	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1321369001375	Ca binding site [ion binding]; other site
1321369001376	active site
1321369001377	catalytic site [active]
1321369001378	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1321369001379	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1321369001380	DNA-binding site [nucleotide binding]; DNA binding site
1321369001381	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1321369001382	UTRA domain; Region: UTRA; pfam07702
1321369001383	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369001384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369001385	Coenzyme A binding pocket [chemical binding]; other site
1321369001386	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1321369001387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369001388	Walker A motif; other site
1321369001389	ATP binding site [chemical binding]; other site
1321369001390	Walker B motif; other site
1321369001391	arginine finger; other site
1321369001392	hypothetical protein; Validated; Region: PRK00153
1321369001393	recombination protein RecR; Reviewed; Region: recR; PRK00076
1321369001394	RecR protein; Region: RecR; pfam02132
1321369001395	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1321369001396	putative active site [active]
1321369001397	putative metal-binding site [ion binding]; other site
1321369001398	tetramer interface [polypeptide binding]; other site
1321369001399	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1321369001400	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1321369001401	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369001402	catalytic residue [active]
1321369001403	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1321369001404	thymidylate kinase; Validated; Region: tmk; PRK00698
1321369001405	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1321369001406	TMP-binding site; other site
1321369001407	ATP-binding site [chemical binding]; other site
1321369001408	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
1321369001409	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1321369001410	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1321369001411	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1321369001412	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
1321369001413	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1321369001414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369001415	S-adenosylmethionine binding site [chemical binding]; other site
1321369001416	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1321369001417	GIY-YIG motif/motif A; other site
1321369001418	putative active site [active]
1321369001419	putative metal binding site [ion binding]; other site
1321369001420	Predicted methyltransferases [General function prediction only]; Region: COG0313
1321369001421	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1321369001422	putative SAM binding site [chemical binding]; other site
1321369001423	putative homodimer interface [polypeptide binding]; other site
1321369001424	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1321369001425	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1321369001426	active site
1321369001427	HIGH motif; other site
1321369001428	KMSKS motif; other site
1321369001429	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1321369001430	tRNA binding surface [nucleotide binding]; other site
1321369001431	anticodon binding site; other site
1321369001432	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1321369001433	dimer interface [polypeptide binding]; other site
1321369001434	putative tRNA-binding site [nucleotide binding]; other site
1321369001435	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1321369001436	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1321369001437	active site
1321369001438	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1321369001439	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1321369001440	putative active site [active]
1321369001441	putative metal binding site [ion binding]; other site
1321369001442	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1321369001443	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1321369001444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369001445	S-adenosylmethionine binding site [chemical binding]; other site
1321369001446	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1321369001447	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1321369001448	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1321369001449	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1321369001450	pur operon repressor; Provisional; Region: PRK09213
1321369001451	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1321369001452	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369001453	active site
1321369001454	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1321369001455	homotrimer interaction site [polypeptide binding]; other site
1321369001456	putative active site [active]
1321369001457	regulatory protein SpoVG; Reviewed; Region: PRK13259
1321369001458	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1321369001459	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1321369001460	Substrate binding site; other site
1321369001461	Mg++ binding site; other site
1321369001462	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1321369001463	active site
1321369001464	substrate binding site [chemical binding]; other site
1321369001465	CoA binding site [chemical binding]; other site
1321369001466	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1321369001467	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1321369001468	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369001469	active site
1321369001470	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1321369001471	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1321369001472	5S rRNA interface [nucleotide binding]; other site
1321369001473	CTC domain interface [polypeptide binding]; other site
1321369001474	L16 interface [polypeptide binding]; other site
1321369001475	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1321369001476	putative active site [active]
1321369001477	catalytic residue [active]
1321369001478	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1321369001479	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1321369001480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369001481	ATP binding site [chemical binding]; other site
1321369001482	putative Mg++ binding site [ion binding]; other site
1321369001483	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369001484	nucleotide binding region [chemical binding]; other site
1321369001485	ATP-binding site [chemical binding]; other site
1321369001486	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1321369001487	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1321369001488	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1321369001489	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1321369001490	putative SAM binding site [chemical binding]; other site
1321369001491	putative homodimer interface [polypeptide binding]; other site
1321369001492	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1321369001493	homodimer interface [polypeptide binding]; other site
1321369001494	metal binding site [ion binding]; metal-binding site
1321369001495	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369001496	RNA binding surface [nucleotide binding]; other site
1321369001497	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1321369001498	Septum formation initiator; Region: DivIC; pfam04977
1321369001499	hypothetical protein; Provisional; Region: PRK08582
1321369001500	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1321369001501	RNA binding site [nucleotide binding]; other site
1321369001502	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1321369001503	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1321369001504	Ligand Binding Site [chemical binding]; other site
1321369001505	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1321369001506	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1321369001507	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369001508	active site
1321369001509	FtsH Extracellular; Region: FtsH_ext; pfam06480
1321369001510	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1321369001511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369001512	Walker A motif; other site
1321369001513	ATP binding site [chemical binding]; other site
1321369001514	Walker B motif; other site
1321369001515	arginine finger; other site
1321369001516	Peptidase family M41; Region: Peptidase_M41; pfam01434
1321369001517	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1321369001518	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1321369001519	dimerization interface [polypeptide binding]; other site
1321369001520	domain crossover interface; other site
1321369001521	redox-dependent activation switch; other site
1321369001522	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1321369001523	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1321369001524	dimer interface [polypeptide binding]; other site
1321369001525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369001526	catalytic residue [active]
1321369001527	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1321369001528	dihydropteroate synthase; Region: DHPS; TIGR01496
1321369001529	substrate binding pocket [chemical binding]; other site
1321369001530	dimer interface [polypeptide binding]; other site
1321369001531	inhibitor binding site; inhibition site
1321369001532	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1321369001533	homooctamer interface [polypeptide binding]; other site
1321369001534	active site
1321369001535	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1321369001536	catalytic center binding site [active]
1321369001537	ATP binding site [chemical binding]; other site
1321369001538	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1321369001539	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1321369001540	dimer interface [polypeptide binding]; other site
1321369001541	putative anticodon binding site; other site
1321369001542	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1321369001543	motif 1; other site
1321369001544	active site
1321369001545	motif 2; other site
1321369001546	motif 3; other site
1321369001547	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1321369001548	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1321369001549	active site
1321369001550	multimer interface [polypeptide binding]; other site
1321369001551	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1321369001552	predicted active site [active]
1321369001553	catalytic triad [active]
1321369001554	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1321369001555	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1321369001556	Nucleoside recognition; Region: Gate; pfam07670
1321369001557	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1321369001558	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1321369001559	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1321369001560	UvrB/uvrC motif; Region: UVR; pfam02151
1321369001561	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
1321369001562	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1321369001563	ADP binding site [chemical binding]; other site
1321369001564	phosphagen binding site; other site
1321369001565	substrate specificity loop; other site
1321369001566	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1321369001567	Clp amino terminal domain; Region: Clp_N; pfam02861
1321369001568	Clp amino terminal domain; Region: Clp_N; pfam02861
1321369001569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369001570	Walker A motif; other site
1321369001571	ATP binding site [chemical binding]; other site
1321369001572	Walker B motif; other site
1321369001573	arginine finger; other site
1321369001574	UvrB/uvrC motif; Region: UVR; pfam02151
1321369001575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369001576	Walker A motif; other site
1321369001577	ATP binding site [chemical binding]; other site
1321369001578	Walker B motif; other site
1321369001579	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1321369001580	DNA repair protein RadA; Provisional; Region: PRK11823
1321369001581	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1321369001582	Walker A motif/ATP binding site; other site
1321369001583	ATP binding site [chemical binding]; other site
1321369001584	Walker B motif; other site
1321369001585	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1321369001586	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1321369001587	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1321369001588	putative active site [active]
1321369001589	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1321369001590	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1321369001591	active site
1321369001592	HIGH motif; other site
1321369001593	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1321369001594	active site
1321369001595	KMSKS motif; other site
1321369001596	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1321369001597	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1321369001598	trimer interface [polypeptide binding]; other site
1321369001599	active site
1321369001600	substrate binding site [chemical binding]; other site
1321369001601	CoA binding site [chemical binding]; other site
1321369001602	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1321369001603	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1321369001604	active site
1321369001605	HIGH motif; other site
1321369001606	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1321369001607	KMSKS motif; other site
1321369001608	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1321369001609	tRNA binding surface [nucleotide binding]; other site
1321369001610	anticodon binding site; other site
1321369001611	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1321369001612	active site
1321369001613	dimerization interface [polypeptide binding]; other site
1321369001614	metal binding site [ion binding]; metal-binding site
1321369001615	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1321369001616	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1321369001617	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1321369001618	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1321369001619	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1321369001620	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1321369001621	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1321369001622	DNA binding residues [nucleotide binding]
1321369001623	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1321369001624	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1321369001625	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1321369001626	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1321369001627	putative homodimer interface [polypeptide binding]; other site
1321369001628	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1321369001629	heterodimer interface [polypeptide binding]; other site
1321369001630	homodimer interface [polypeptide binding]; other site
1321369001631	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1321369001632	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1321369001633	23S rRNA interface [nucleotide binding]; other site
1321369001634	L7/L12 interface [polypeptide binding]; other site
1321369001635	putative thiostrepton binding site; other site
1321369001636	L25 interface [polypeptide binding]; other site
1321369001637	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1321369001638	mRNA/rRNA interface [nucleotide binding]; other site
1321369001639	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1321369001640	23S rRNA interface [nucleotide binding]; other site
1321369001641	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1321369001642	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1321369001643	peripheral dimer interface [polypeptide binding]; other site
1321369001644	core dimer interface [polypeptide binding]; other site
1321369001645	L10 interface [polypeptide binding]; other site
1321369001646	L11 interface [polypeptide binding]; other site
1321369001647	putative EF-Tu interaction site [polypeptide binding]; other site
1321369001648	putative EF-G interaction site [polypeptide binding]; other site
1321369001649	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1321369001650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369001651	S-adenosylmethionine binding site [chemical binding]; other site
1321369001652	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1321369001653	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1321369001654	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1321369001655	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1321369001656	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1321369001657	RPB10 interaction site [polypeptide binding]; other site
1321369001658	RPB1 interaction site [polypeptide binding]; other site
1321369001659	RPB11 interaction site [polypeptide binding]; other site
1321369001660	RPB3 interaction site [polypeptide binding]; other site
1321369001661	RPB12 interaction site [polypeptide binding]; other site
1321369001662	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1321369001663	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1321369001664	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1321369001665	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1321369001666	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1321369001667	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1321369001668	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1321369001669	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1321369001670	G-loop; other site
1321369001671	DNA binding site [nucleotide binding]
1321369001672	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
1321369001673	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1321369001674	S17 interaction site [polypeptide binding]; other site
1321369001675	S8 interaction site; other site
1321369001676	16S rRNA interaction site [nucleotide binding]; other site
1321369001677	streptomycin interaction site [chemical binding]; other site
1321369001678	23S rRNA interaction site [nucleotide binding]; other site
1321369001679	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1321369001680	30S ribosomal protein S7; Validated; Region: PRK05302
1321369001681	elongation factor G; Reviewed; Region: PRK00007
1321369001682	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1321369001683	G1 box; other site
1321369001684	putative GEF interaction site [polypeptide binding]; other site
1321369001685	GTP/Mg2+ binding site [chemical binding]; other site
1321369001686	Switch I region; other site
1321369001687	G2 box; other site
1321369001688	G3 box; other site
1321369001689	Switch II region; other site
1321369001690	G4 box; other site
1321369001691	G5 box; other site
1321369001692	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1321369001693	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1321369001694	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1321369001695	elongation factor Tu; Reviewed; Region: PRK00049
1321369001696	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1321369001697	G1 box; other site
1321369001698	GEF interaction site [polypeptide binding]; other site
1321369001699	GTP/Mg2+ binding site [chemical binding]; other site
1321369001700	Switch I region; other site
1321369001701	G2 box; other site
1321369001702	G3 box; other site
1321369001703	Switch II region; other site
1321369001704	G4 box; other site
1321369001705	G5 box; other site
1321369001706	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1321369001707	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1321369001708	Antibiotic Binding Site [chemical binding]; other site
1321369001709	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1321369001710	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1321369001711	metal binding site [ion binding]; metal-binding site
1321369001712	dimer interface [polypeptide binding]; other site
1321369001713	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1321369001714	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1321369001715	substrate-cofactor binding pocket; other site
1321369001716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369001717	catalytic residue [active]
1321369001718	chaperone protein HchA; Provisional; Region: PRK04155
1321369001719	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
1321369001720	dimer interface [polypeptide binding]; other site
1321369001721	metal binding site [ion binding]; metal-binding site
1321369001722	potential oxyanion hole; other site
1321369001723	potential catalytic triad [active]
1321369001724	conserved cys residue [active]
1321369001725	ribulokinase; Provisional; Region: PRK04123
1321369001726	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1321369001727	N- and C-terminal domain interface [polypeptide binding]; other site
1321369001728	active site
1321369001729	MgATP binding site [chemical binding]; other site
1321369001730	catalytic site [active]
1321369001731	metal binding site [ion binding]; metal-binding site
1321369001732	carbohydrate binding site [chemical binding]; other site
1321369001733	homodimer interface [polypeptide binding]; other site
1321369001734	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1321369001735	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369001736	NAD(P) binding site [chemical binding]; other site
1321369001737	active site
1321369001738	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1321369001739	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1321369001740	homodimer interface [polypeptide binding]; other site
1321369001741	substrate-cofactor binding pocket; other site
1321369001742	catalytic residue [active]
1321369001743	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1321369001744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369001745	motif II; other site
1321369001746	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1321369001747	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1321369001748	Substrate-binding site [chemical binding]; other site
1321369001749	Substrate specificity [chemical binding]; other site
1321369001750	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1321369001751	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1321369001752	Substrate-binding site [chemical binding]; other site
1321369001753	Substrate specificity [chemical binding]; other site
1321369001754	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1321369001755	nucleoside/Zn binding site; other site
1321369001756	dimer interface [polypeptide binding]; other site
1321369001757	catalytic motif [active]
1321369001758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369001759	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1321369001760	active site
1321369001761	motif I; other site
1321369001762	motif II; other site
1321369001763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369001764	Predicted flavoprotein [General function prediction only]; Region: COG0431
1321369001765	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1321369001766	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369001767	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369001768	Cna protein B-type domain; Region: Cna_B; pfam05738
1321369001769	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1321369001770	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369001771	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369001772	Cna protein B-type domain; Region: Cna_B; pfam05738
1321369001773	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1321369001774	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1321369001775	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1321369001776	Cna protein B-type domain; Region: Cna_B; pfam05738
1321369001777	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369001778	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369001779	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1321369001780	Cna protein B-type domain; Region: Cna_B; pfam05738
1321369001781	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1321369001782	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1321369001783	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1321369001784	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1321369001785	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1321369001786	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1321369001787	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1321369001788	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1321369001789	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1321369001790	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1321369001791	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1321369001792	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1321369001793	active site
1321369001794	trimer interface [polypeptide binding]; other site
1321369001795	allosteric site; other site
1321369001796	active site lid [active]
1321369001797	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1321369001798	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1321369001799	active site
1321369001800	dimer interface [polypeptide binding]; other site
1321369001801	magnesium binding site [ion binding]; other site
1321369001802	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1321369001803	tetramer interface [polypeptide binding]; other site
1321369001804	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1321369001805	active site
1321369001806	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1321369001807	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369001808	motif II; other site
1321369001809	proline/glycine betaine transporter; Provisional; Region: PRK10642
1321369001810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369001811	putative substrate translocation pore; other site
1321369001812	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1321369001813	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1321369001814	acyl-activating enzyme (AAE) consensus motif; other site
1321369001815	AMP binding site [chemical binding]; other site
1321369001816	active site
1321369001817	CoA binding site [chemical binding]; other site
1321369001818	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1321369001819	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1321369001820	dimer interface [polypeptide binding]; other site
1321369001821	active site
1321369001822	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1321369001823	dimer interface [polypeptide binding]; other site
1321369001824	substrate binding site [chemical binding]; other site
1321369001825	ATP binding site [chemical binding]; other site
1321369001826	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1321369001827	ligand binding site [chemical binding]; other site
1321369001828	active site
1321369001829	UGI interface [polypeptide binding]; other site
1321369001830	catalytic site [active]
1321369001831	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1321369001832	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1321369001833	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1321369001834	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1321369001835	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1321369001836	putative heme peroxidase; Provisional; Region: PRK12276
1321369001837	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1321369001838	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1321369001839	mevalonate kinase; Region: mevalon_kin; TIGR00549
1321369001840	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1321369001841	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1321369001842	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1321369001843	diphosphomevalonate decarboxylase; Region: PLN02407
1321369001844	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1321369001845	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1321369001846	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1321369001847	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1321369001848	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1321369001849	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1321369001850	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369001851	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1321369001852	Predicted transcriptional regulator [Transcription]; Region: COG1959
1321369001853	Transcriptional regulator; Region: Rrf2; pfam02082
1321369001854	LXG domain of WXG superfamily; Region: LXG; pfam04740
1321369001855	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1321369001856	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1321369001857	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1321369001858	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369001859	MULE transposase domain; Region: MULE; pfam10551
1321369001860	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1321369001861	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1321369001862	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1321369001863	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1321369001864	active site
1321369001865	catalytic tetrad [active]
1321369001866	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1321369001867	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1321369001868	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1321369001869	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369001870	Coenzyme A binding pocket [chemical binding]; other site
1321369001871	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1321369001872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1321369001873	Zn2+ binding site [ion binding]; other site
1321369001874	Mg2+ binding site [ion binding]; other site
1321369001875	YwhD family; Region: YwhD; pfam08741
1321369001876	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1321369001877	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1321369001878	NAD binding site [chemical binding]; other site
1321369001879	substrate binding site [chemical binding]; other site
1321369001880	catalytic Zn binding site [ion binding]; other site
1321369001881	tetramer interface [polypeptide binding]; other site
1321369001882	structural Zn binding site [ion binding]; other site
1321369001883	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1321369001884	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1321369001885	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1321369001886	active site
1321369001887	HIGH motif; other site
1321369001888	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1321369001889	KMSK motif region; other site
1321369001890	tRNA binding surface [nucleotide binding]; other site
1321369001891	DALR anticodon binding domain; Region: DALR_1; smart00836
1321369001892	anticodon binding site; other site
1321369001893	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1321369001894	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1321369001895	minor groove reading motif; other site
1321369001896	helix-hairpin-helix signature motif; other site
1321369001897	substrate binding pocket [chemical binding]; other site
1321369001898	active site
1321369001899	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1321369001900	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1321369001901	putative binding site residues; other site
1321369001902	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1321369001903	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369001904	ABC-ATPase subunit  interface; other site
1321369001905	dimer interface [polypeptide binding]; other site
1321369001906	putative PBP binding regions; other site
1321369001907	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1321369001908	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369001909	motif II; other site
1321369001910	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1321369001911	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1321369001912	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1321369001913	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1321369001914	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369001915	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369001916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1321369001917	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1321369001918	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1321369001919	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1321369001920	active site
1321369001921	DNA binding site [nucleotide binding]
1321369001922	Int/Topo IB signature motif; other site
1321369001923	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
1321369001924	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1321369001925	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1321369001926	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
1321369001927	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
1321369001928	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1321369001929	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1321369001930	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1321369001931	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
1321369001932	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1321369001933	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1321369001934	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1321369001935	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1321369001936	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1321369001937	metal binding site [ion binding]; metal-binding site
1321369001938	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1321369001939	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369001940	ABC-ATPase subunit  interface; other site
1321369001941	dimer interface [polypeptide binding]; other site
1321369001942	putative PBP binding regions; other site
1321369001943	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1321369001944	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1321369001945	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1321369001946	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1321369001947	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1321369001948	FeoA domain; Region: FeoA; pfam04023
1321369001949	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1321369001950	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1321369001951	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1321369001952	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
1321369001953	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1321369001954	Walker A/P-loop; other site
1321369001955	ATP binding site [chemical binding]; other site
1321369001956	Q-loop/lid; other site
1321369001957	ABC transporter signature motif; other site
1321369001958	Walker B; other site
1321369001959	D-loop; other site
1321369001960	H-loop/switch region; other site
1321369001961	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1321369001962	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1321369001963	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1321369001964	active site
1321369001965	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1321369001966	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1321369001967	active site
1321369001968	nucleotide binding site [chemical binding]; other site
1321369001969	HIGH motif; other site
1321369001970	KMSKS motif; other site
1321369001971	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1321369001972	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1321369001973	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1321369001974	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1321369001975	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1321369001976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369001977	Walker A/P-loop; other site
1321369001978	ATP binding site [chemical binding]; other site
1321369001979	Q-loop/lid; other site
1321369001980	ABC transporter signature motif; other site
1321369001981	Walker B; other site
1321369001982	D-loop; other site
1321369001983	H-loop/switch region; other site
1321369001984	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1321369001985	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1321369001986	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1321369001987	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1321369001988	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1321369001989	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1321369001990	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1321369001991	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1321369001992	Walker A/P-loop; other site
1321369001993	ATP binding site [chemical binding]; other site
1321369001994	Q-loop/lid; other site
1321369001995	ABC transporter signature motif; other site
1321369001996	Walker B; other site
1321369001997	D-loop; other site
1321369001998	H-loop/switch region; other site
1321369001999	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1321369002000	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369002001	ABC-ATPase subunit  interface; other site
1321369002002	dimer interface [polypeptide binding]; other site
1321369002003	putative PBP binding regions; other site
1321369002004	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1321369002005	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369002006	ABC-ATPase subunit  interface; other site
1321369002007	dimer interface [polypeptide binding]; other site
1321369002008	putative PBP binding regions; other site
1321369002009	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1321369002010	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1321369002011	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1321369002012	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1321369002013	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1321369002014	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1321369002015	Na binding site [ion binding]; other site
1321369002016	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1321369002017	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1321369002018	substrate binding pocket [chemical binding]; other site
1321369002019	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1321369002020	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369002021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369002022	Coenzyme A binding pocket [chemical binding]; other site
1321369002023	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369002024	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1321369002025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369002026	NAD(P) binding site [chemical binding]; other site
1321369002027	active site
1321369002028	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369002029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369002030	active site
1321369002031	phosphorylation site [posttranslational modification]
1321369002032	intermolecular recognition site; other site
1321369002033	dimerization interface [polypeptide binding]; other site
1321369002034	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369002035	DNA binding site [nucleotide binding]
1321369002036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1321369002037	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1321369002038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369002039	ATP binding site [chemical binding]; other site
1321369002040	Mg2+ binding site [ion binding]; other site
1321369002041	G-X-G motif; other site
1321369002042	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1321369002043	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1321369002044	Walker A/P-loop; other site
1321369002045	ATP binding site [chemical binding]; other site
1321369002046	Q-loop/lid; other site
1321369002047	ABC transporter signature motif; other site
1321369002048	Walker B; other site
1321369002049	D-loop; other site
1321369002050	H-loop/switch region; other site
1321369002051	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1321369002052	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1321369002053	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369002054	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1321369002055	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369002056	Surface antigen [General function prediction only]; Region: COG3942
1321369002057	CHAP domain; Region: CHAP; pfam05257
1321369002058	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1321369002059	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1321369002060	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1321369002061	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369002062	hypothetical protein; Provisional; Region: PRK12378
1321369002063	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1321369002064	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1321369002065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1321369002066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1321369002067	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1321369002068	dimerization interface [polypeptide binding]; other site
1321369002069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369002070	sugar efflux transporter; Region: 2A0120; TIGR00899
1321369002071	putative substrate translocation pore; other site
1321369002072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1321369002073	Serine incorporator (Serinc); Region: Serinc; pfam03348
1321369002074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369002075	Coenzyme A binding pocket [chemical binding]; other site
1321369002076	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1321369002077	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1321369002078	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
1321369002079	hypothetical protein; Validated; Region: PRK00124
1321369002080	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1321369002081	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1321369002082	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1321369002083	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1321369002084	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1321369002085	Walker A/P-loop; other site
1321369002086	ATP binding site [chemical binding]; other site
1321369002087	Q-loop/lid; other site
1321369002088	ABC transporter signature motif; other site
1321369002089	Walker B; other site
1321369002090	D-loop; other site
1321369002091	H-loop/switch region; other site
1321369002092	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1321369002093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1321369002094	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1321369002095	Walker A/P-loop; other site
1321369002096	ATP binding site [chemical binding]; other site
1321369002097	Q-loop/lid; other site
1321369002098	ABC transporter signature motif; other site
1321369002099	Walker B; other site
1321369002100	D-loop; other site
1321369002101	H-loop/switch region; other site
1321369002102	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369002103	MarR family; Region: MarR; pfam01047
1321369002104	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369002105	MULE transposase domain; Region: MULE; pfam10551
1321369002106	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1321369002107	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1321369002108	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1321369002109	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1321369002110	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1321369002111	active site
1321369002112	catalytic tetrad [active]
1321369002113	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1321369002114	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1321369002115	transmembrane helices; other site
1321369002116	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1321369002117	DNA photolyase; Region: DNA_photolyase; pfam00875
1321369002118	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1321369002119	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369002120	MULE transposase domain; Region: MULE; pfam10551
1321369002121	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1321369002122	trimer interface [polypeptide binding]; other site
1321369002123	putative Zn binding site [ion binding]; other site
1321369002124	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1321369002125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369002126	putative substrate translocation pore; other site
1321369002127	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1321369002128	putative deacylase active site [active]
1321369002129	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1321369002130	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1321369002131	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1321369002132	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1321369002133	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1321369002134	putative substrate binding site [chemical binding]; other site
1321369002135	putative ATP binding site [chemical binding]; other site
1321369002136	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1321369002137	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369002138	active site
1321369002139	phosphorylation site [posttranslational modification]
1321369002140	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1321369002141	active site
1321369002142	P-loop; other site
1321369002143	phosphorylation site [posttranslational modification]
1321369002144	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1321369002145	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1321369002146	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1321369002147	active site
1321369002148	dimer interface [polypeptide binding]; other site
1321369002149	Domain of unknown function DUF21; Region: DUF21; pfam01595
1321369002150	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1321369002151	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1321369002152	Transporter associated domain; Region: CorC_HlyC; pfam03471
1321369002153	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1321369002154	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1321369002155	active site
1321369002156	catalytic tetrad [active]
1321369002157	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1321369002158	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1321369002159	Ligand binding site; other site
1321369002160	Putative Catalytic site; other site
1321369002161	DXD motif; other site
1321369002162	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1321369002163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369002164	dimer interface [polypeptide binding]; other site
1321369002165	phosphorylation site [posttranslational modification]
1321369002166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369002167	ATP binding site [chemical binding]; other site
1321369002168	Mg2+ binding site [ion binding]; other site
1321369002169	G-X-G motif; other site
1321369002170	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369002171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369002172	active site
1321369002173	phosphorylation site [posttranslational modification]
1321369002174	intermolecular recognition site; other site
1321369002175	dimerization interface [polypeptide binding]; other site
1321369002176	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369002177	DNA binding site [nucleotide binding]
1321369002178	DoxX; Region: DoxX; pfam07681
1321369002179	Electron transfer DM13; Region: DM13; pfam10517
1321369002180	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1321369002181	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1321369002182	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1321369002183	active site
1321369002184	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1321369002185	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1321369002186	Ligand Binding Site [chemical binding]; other site
1321369002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369002188	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369002189	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369002190	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1321369002191	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1321369002192	glutamine binding [chemical binding]; other site
1321369002193	catalytic triad [active]
1321369002194	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1321369002195	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1321369002196	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1321369002197	substrate-cofactor binding pocket; other site
1321369002198	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1321369002199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369002200	catalytic residue [active]
1321369002201	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1321369002202	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1321369002203	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1321369002204	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1321369002205	Sulfatase; Region: Sulfatase; pfam00884
1321369002206	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1321369002207	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369002208	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369002209	ABC transporter; Region: ABC_tran_2; pfam12848
1321369002210	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369002211	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1321369002212	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369002213	ATP binding site [chemical binding]; other site
1321369002214	putative Mg++ binding site [ion binding]; other site
1321369002215	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369002216	nucleotide binding region [chemical binding]; other site
1321369002217	ATP-binding site [chemical binding]; other site
1321369002218	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1321369002219	HRDC domain; Region: HRDC; pfam00570
1321369002220	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1321369002221	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1321369002222	Walker A/P-loop; other site
1321369002223	ATP binding site [chemical binding]; other site
1321369002224	Q-loop/lid; other site
1321369002225	ABC transporter signature motif; other site
1321369002226	Walker B; other site
1321369002227	D-loop; other site
1321369002228	H-loop/switch region; other site
1321369002229	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1321369002230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369002231	dimer interface [polypeptide binding]; other site
1321369002232	conserved gate region; other site
1321369002233	ABC-ATPase subunit interface; other site
1321369002234	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1321369002235	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1321369002236	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1321369002237	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1321369002238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369002239	homodimer interface [polypeptide binding]; other site
1321369002240	catalytic residue [active]
1321369002241	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1321369002242	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1321369002243	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1321369002244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369002245	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369002246	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369002247	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1321369002248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369002249	putative substrate translocation pore; other site
1321369002250	POT family; Region: PTR2; cl17359
1321369002251	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1321369002252	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1321369002253	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
1321369002254	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1321369002255	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1321369002256	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1321369002257	active site
1321369002258	dimer interface [polypeptide binding]; other site
1321369002259	catalytic residues [active]
1321369002260	effector binding site; other site
1321369002261	R2 peptide binding site; other site
1321369002262	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1321369002263	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1321369002264	dimer interface [polypeptide binding]; other site
1321369002265	putative radical transfer pathway; other site
1321369002266	diiron center [ion binding]; other site
1321369002267	tyrosyl radical; other site
1321369002268	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369002269	ABC-ATPase subunit  interface; other site
1321369002270	dimer interface [polypeptide binding]; other site
1321369002271	putative PBP binding regions; other site
1321369002272	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369002273	ABC-ATPase subunit  interface; other site
1321369002274	dimer interface [polypeptide binding]; other site
1321369002275	putative PBP binding regions; other site
1321369002276	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1321369002277	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1321369002278	Walker A/P-loop; other site
1321369002279	ATP binding site [chemical binding]; other site
1321369002280	Q-loop/lid; other site
1321369002281	ABC transporter signature motif; other site
1321369002282	Walker B; other site
1321369002283	D-loop; other site
1321369002284	H-loop/switch region; other site
1321369002285	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1321369002286	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1321369002287	putative ligand binding residues [chemical binding]; other site
1321369002288	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1321369002289	CHY zinc finger; Region: zf-CHY; pfam05495
1321369002290	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1321369002291	FAD binding domain; Region: FAD_binding_4; pfam01565
1321369002292	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1321369002293	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1321369002294	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1321369002295	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1321369002296	peptidase T; Region: peptidase-T; TIGR01882
1321369002297	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1321369002298	metal binding site [ion binding]; metal-binding site
1321369002299	dimer interface [polypeptide binding]; other site
1321369002300	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1321369002301	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1321369002302	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1321369002303	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1321369002304	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1321369002305	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1321369002306	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1321369002307	metal binding site [ion binding]; metal-binding site
1321369002308	active site
1321369002309	I-site; other site
1321369002310	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1321369002311	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1321369002312	Mg++ binding site [ion binding]; other site
1321369002313	putative catalytic motif [active]
1321369002314	substrate binding site [chemical binding]; other site
1321369002315	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1321369002316	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1321369002317	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1321369002318	EDD domain protein, DegV family; Region: DegV; TIGR00762
1321369002319	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1321369002320	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1321369002321	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369002322	ATP binding site [chemical binding]; other site
1321369002323	putative Mg++ binding site [ion binding]; other site
1321369002324	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369002325	nucleotide binding region [chemical binding]; other site
1321369002326	ATP-binding site [chemical binding]; other site
1321369002327	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1321369002328	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369002329	active site
1321369002330	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1321369002331	30S subunit binding site; other site
1321369002332	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1321369002333	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1321369002334	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1321369002335	nucleotide binding region [chemical binding]; other site
1321369002336	ATP-binding site [chemical binding]; other site
1321369002337	SEC-C motif; Region: SEC-C; pfam02810
1321369002338	peptide chain release factor 2; Provisional; Region: PRK06746
1321369002339	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1321369002340	RF-1 domain; Region: RF-1; pfam00472
1321369002341	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1321369002342	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369002343	Surface antigen [General function prediction only]; Region: COG3942
1321369002344	CHAP domain; Region: CHAP; pfam05257
1321369002345	HD domain; Region: HD_3; cl17350
1321369002346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
1321369002347	excinuclease ABC subunit B; Provisional; Region: PRK05298
1321369002348	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369002349	ATP binding site [chemical binding]; other site
1321369002350	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369002351	nucleotide binding region [chemical binding]; other site
1321369002352	ATP-binding site [chemical binding]; other site
1321369002353	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1321369002354	UvrB/uvrC motif; Region: UVR; pfam02151
1321369002355	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1321369002356	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1321369002357	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1321369002358	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1321369002359	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1321369002360	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1321369002361	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1321369002362	Hpr binding site; other site
1321369002363	active site
1321369002364	homohexamer subunit interaction site [polypeptide binding]; other site
1321369002365	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1321369002366	putative acyl transferase; Provisional; Region: PRK10191
1321369002367	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1321369002368	trimer interface [polypeptide binding]; other site
1321369002369	active site
1321369002370	substrate binding site [chemical binding]; other site
1321369002371	CoA binding site [chemical binding]; other site
1321369002372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1321369002373	binding surface
1321369002374	TPR motif; other site
1321369002375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1321369002376	TPR motif; other site
1321369002377	binding surface
1321369002378	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1321369002379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369002380	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369002381	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1321369002382	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1321369002383	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1321369002384	phosphate binding site [ion binding]; other site
1321369002385	dimer interface [polypeptide binding]; other site
1321369002386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1321369002387	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1321369002388	Clp protease; Region: CLP_protease; pfam00574
1321369002389	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1321369002390	oligomer interface [polypeptide binding]; other site
1321369002391	active site residues [active]
1321369002392	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1321369002393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369002394	NAD(P) binding site [chemical binding]; other site
1321369002395	active site
1321369002396	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1321369002397	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1321369002398	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1321369002399	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1321369002400	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1321369002401	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1321369002402	Phosphoglycerate kinase; Region: PGK; pfam00162
1321369002403	substrate binding site [chemical binding]; other site
1321369002404	hinge regions; other site
1321369002405	ADP binding site [chemical binding]; other site
1321369002406	catalytic site [active]
1321369002407	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1321369002408	triosephosphate isomerase; Provisional; Region: PRK14565
1321369002409	substrate binding site [chemical binding]; other site
1321369002410	dimer interface [polypeptide binding]; other site
1321369002411	catalytic triad [active]
1321369002412	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1321369002413	phosphoglyceromutase; Provisional; Region: PRK05434
1321369002414	enolase; Provisional; Region: eno; PRK00077
1321369002415	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1321369002416	dimer interface [polypeptide binding]; other site
1321369002417	metal binding site [ion binding]; metal-binding site
1321369002418	substrate binding pocket [chemical binding]; other site
1321369002419	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1321369002420	Esterase/lipase [General function prediction only]; Region: COG1647
1321369002421	Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735
1321369002422	ribonuclease R; Region: RNase_R; TIGR02063
1321369002423	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1321369002424	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1321369002425	RNB domain; Region: RNB; pfam00773
1321369002426	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1321369002427	RNA binding site [nucleotide binding]; other site
1321369002428	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1321369002429	SmpB-tmRNA interface; other site
1321369002430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369002431	Coenzyme A binding pocket [chemical binding]; other site
1321369002432	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369002433	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369002434	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1321369002435	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1321369002436	Staphylococcal nuclease homologues; Region: SNc; smart00318
1321369002437	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1321369002438	Catalytic site; other site
1321369002439	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369002440	MULE transposase domain; Region: MULE; pfam10551
1321369002441	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1321369002442	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1321369002443	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1321369002444	catalytic core [active]
1321369002445	Lysine efflux permease [General function prediction only]; Region: COG1279
1321369002446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369002447	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1321369002448	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369002449	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1321369002450	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1321369002451	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1321369002452	active site
1321369002453	catalytic residue [active]
1321369002454	dimer interface [polypeptide binding]; other site
1321369002455	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1321369002456	putative FMN binding site [chemical binding]; other site
1321369002457	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1321369002458	catalytic residues [active]
1321369002459	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1321369002460	ArsC family; Region: ArsC; pfam03960
1321369002461	putative ArsC-like catalytic residues; other site
1321369002462	putative TRX-like catalytic residues [active]
1321369002463	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1321369002464	lipoyl attachment site [posttranslational modification]; other site
1321369002465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1321369002466	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1321369002467	putative active site [active]
1321369002468	putative metal binding site [ion binding]; other site
1321369002469	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1321369002470	catalytic residues [active]
1321369002471	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1321369002472	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1321369002473	Walker A/P-loop; other site
1321369002474	ATP binding site [chemical binding]; other site
1321369002475	Q-loop/lid; other site
1321369002476	ABC transporter signature motif; other site
1321369002477	Walker B; other site
1321369002478	D-loop; other site
1321369002479	H-loop/switch region; other site
1321369002480	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1321369002481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369002482	dimer interface [polypeptide binding]; other site
1321369002483	conserved gate region; other site
1321369002484	ABC-ATPase subunit interface; other site
1321369002485	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1321369002486	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1321369002487	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1321369002488	Int/Topo IB signature motif; other site
1321369002489	SAP domain; Region: SAP; pfam02037
1321369002490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369002491	non-specific DNA binding site [nucleotide binding]; other site
1321369002492	salt bridge; other site
1321369002493	sequence-specific DNA binding site [nucleotide binding]; other site
1321369002494	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369002495	non-specific DNA binding site [nucleotide binding]; other site
1321369002496	salt bridge; other site
1321369002497	sequence-specific DNA binding site [nucleotide binding]; other site
1321369002498	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
1321369002499	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1321369002500	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
1321369002501	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
1321369002502	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1321369002503	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
1321369002504	Predicted membrane protein [Function unknown]; Region: COG2035
1321369002505	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1321369002506	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1321369002507	Walker A/P-loop; other site
1321369002508	ATP binding site [chemical binding]; other site
1321369002509	Q-loop/lid; other site
1321369002510	ABC transporter signature motif; other site
1321369002511	Walker B; other site
1321369002512	D-loop; other site
1321369002513	H-loop/switch region; other site
1321369002514	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1321369002515	FeS assembly protein SufD; Region: sufD; TIGR01981
1321369002516	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1321369002517	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1321369002518	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369002519	catalytic residue [active]
1321369002520	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1321369002521	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1321369002522	trimerization site [polypeptide binding]; other site
1321369002523	active site
1321369002524	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1321369002525	FeS assembly protein SufB; Region: sufB; TIGR01980
1321369002526	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1321369002527	Domain of unknown function DUF21; Region: DUF21; pfam01595
1321369002528	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1321369002529	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1321369002530	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1321369002531	FMN binding site [chemical binding]; other site
1321369002532	substrate binding site [chemical binding]; other site
1321369002533	putative catalytic residue [active]
1321369002534	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1321369002535	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1321369002536	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1321369002537	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1321369002538	active site
1321369002539	metal binding site [ion binding]; metal-binding site
1321369002540	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1321369002541	lipoyl synthase; Provisional; Region: PRK05481
1321369002542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369002543	FeS/SAM binding site; other site
1321369002544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
1321369002545	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1321369002546	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1321369002547	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1321369002548	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369002549	active site
1321369002550	motif I; other site
1321369002551	motif II; other site
1321369002552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369002553	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1321369002554	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1321369002555	dimerization interface [polypeptide binding]; other site
1321369002556	ligand binding site [chemical binding]; other site
1321369002557	NADP binding site [chemical binding]; other site
1321369002558	catalytic site [active]
1321369002559	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1321369002560	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1321369002561	acyl-activating enzyme (AAE) consensus motif; other site
1321369002562	AMP binding site [chemical binding]; other site
1321369002563	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1321369002564	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1321369002565	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1321369002566	DltD N-terminal region; Region: DltD_N; pfam04915
1321369002567	DltD central region; Region: DltD_M; pfam04918
1321369002568	DltD C-terminal region; Region: DltD_C; pfam04914
1321369002569	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1321369002570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
1321369002571	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1321369002572	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369002573	hypothetical protein; Provisional; Region: PRK13669
1321369002574	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1321369002575	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1321369002576	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369002577	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1321369002578	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1321369002579	interface (dimer of trimers) [polypeptide binding]; other site
1321369002580	Substrate-binding/catalytic site; other site
1321369002581	Zn-binding sites [ion binding]; other site
1321369002582	Predicted permease [General function prediction only]; Region: COG2056
1321369002583	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1321369002584	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1321369002585	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1321369002586	CoenzymeA binding site [chemical binding]; other site
1321369002587	subunit interaction site [polypeptide binding]; other site
1321369002588	PHB binding site; other site
1321369002589	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369002590	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1321369002591	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
1321369002592	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
1321369002593	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
1321369002594	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1321369002595	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1321369002596	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
1321369002597	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1321369002598	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1321369002599	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1321369002600	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1321369002601	Kinase associated protein B; Region: KapB; pfam08810
1321369002602	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1321369002603	active site
1321369002604	general stress protein 13; Validated; Region: PRK08059
1321369002605	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1321369002606	RNA binding site [nucleotide binding]; other site
1321369002607	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1321369002608	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1321369002609	putative active site [active]
1321369002610	putative FMN binding site [chemical binding]; other site
1321369002611	putative substrate binding site [chemical binding]; other site
1321369002612	putative catalytic residue [active]
1321369002613	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1321369002614	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1321369002615	inhibitor-cofactor binding pocket; inhibition site
1321369002616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369002617	catalytic residue [active]
1321369002618	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1321369002619	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1321369002620	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1321369002621	NAD(P) binding site [chemical binding]; other site
1321369002622	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1321369002623	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1321369002624	active site
1321369002625	catalytic site [active]
1321369002626	metal binding site [ion binding]; metal-binding site
1321369002627	argininosuccinate lyase; Provisional; Region: PRK00855
1321369002628	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1321369002629	active sites [active]
1321369002630	tetramer interface [polypeptide binding]; other site
1321369002631	argininosuccinate synthase; Provisional; Region: PRK13820
1321369002632	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1321369002633	ANP binding site [chemical binding]; other site
1321369002634	Substrate Binding Site II [chemical binding]; other site
1321369002635	Substrate Binding Site I [chemical binding]; other site
1321369002636	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1321369002637	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1321369002638	active site
1321369002639	dimer interface [polypeptide binding]; other site
1321369002640	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1321369002641	dimer interface [polypeptide binding]; other site
1321369002642	active site
1321369002643	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1321369002644	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1321369002645	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1321369002646	Catalytic site [active]
1321369002647	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1321369002648	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1321369002649	Catalytic site [active]
1321369002650	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1321369002651	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1321369002652	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1321369002653	Part of AAA domain; Region: AAA_19; pfam13245
1321369002654	Family description; Region: UvrD_C_2; pfam13538
1321369002655	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1321369002656	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1321369002657	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1321369002658	hypothetical protein; Provisional; Region: PRK13673
1321369002659	coenzyme A disulfide reductase; Provisional; Region: PRK13512
1321369002660	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369002661	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369002662	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1321369002663	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1321369002664	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369002665	active site
1321369002666	motif I; other site
1321369002667	motif II; other site
1321369002668	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369002669	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1321369002670	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1321369002671	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1321369002672	catalytic triad [active]
1321369002673	catalytic triad [active]
1321369002674	oxyanion hole [active]
1321369002675	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1321369002676	Clp amino terminal domain; Region: Clp_N; pfam02861
1321369002677	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369002678	Walker A motif; other site
1321369002679	ATP binding site [chemical binding]; other site
1321369002680	Walker B motif; other site
1321369002681	arginine finger; other site
1321369002682	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1321369002683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369002684	Walker A motif; other site
1321369002685	ATP binding site [chemical binding]; other site
1321369002686	Walker B motif; other site
1321369002687	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1321369002688	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1321369002689	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1321369002690	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1321369002691	dimerization interface [polypeptide binding]; other site
1321369002692	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1321369002693	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1321369002694	active site
1321369002695	catalytic residues [active]
1321369002696	metal binding site [ion binding]; metal-binding site
1321369002697	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1321369002698	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1321369002699	substrate binding site [chemical binding]; other site
1321369002700	MAP domain; Region: MAP; pfam03642
1321369002701	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1321369002702	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1321369002703	dimer interface [polypeptide binding]; other site
1321369002704	active site
1321369002705	CoA binding pocket [chemical binding]; other site
1321369002706	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1321369002707	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1321369002708	dimer interface [polypeptide binding]; other site
1321369002709	active site
1321369002710	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1321369002711	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1321369002712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369002713	dimer interface [polypeptide binding]; other site
1321369002714	conserved gate region; other site
1321369002715	putative PBP binding loops; other site
1321369002716	ABC-ATPase subunit interface; other site
1321369002717	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1321369002718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369002719	dimer interface [polypeptide binding]; other site
1321369002720	conserved gate region; other site
1321369002721	putative PBP binding loops; other site
1321369002722	ABC-ATPase subunit interface; other site
1321369002723	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1321369002724	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369002725	Walker A/P-loop; other site
1321369002726	ATP binding site [chemical binding]; other site
1321369002727	Q-loop/lid; other site
1321369002728	ABC transporter signature motif; other site
1321369002729	Walker B; other site
1321369002730	D-loop; other site
1321369002731	H-loop/switch region; other site
1321369002732	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1321369002733	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1321369002734	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369002735	Walker A/P-loop; other site
1321369002736	ATP binding site [chemical binding]; other site
1321369002737	Q-loop/lid; other site
1321369002738	ABC transporter signature motif; other site
1321369002739	Walker B; other site
1321369002740	D-loop; other site
1321369002741	H-loop/switch region; other site
1321369002742	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1321369002743	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1321369002744	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1321369002745	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1321369002746	peptide binding site [polypeptide binding]; other site
1321369002747	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1321369002748	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1321369002749	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1321369002750	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369002751	Walker A/P-loop; other site
1321369002752	ATP binding site [chemical binding]; other site
1321369002753	Q-loop/lid; other site
1321369002754	ABC transporter signature motif; other site
1321369002755	Walker B; other site
1321369002756	D-loop; other site
1321369002757	H-loop/switch region; other site
1321369002758	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1321369002759	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1321369002760	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369002761	Walker A/P-loop; other site
1321369002762	ATP binding site [chemical binding]; other site
1321369002763	Q-loop/lid; other site
1321369002764	ABC transporter signature motif; other site
1321369002765	Walker B; other site
1321369002766	D-loop; other site
1321369002767	H-loop/switch region; other site
1321369002768	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1321369002769	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1321369002770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369002771	conserved gate region; other site
1321369002772	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1321369002773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369002774	dimer interface [polypeptide binding]; other site
1321369002775	conserved gate region; other site
1321369002776	putative PBP binding loops; other site
1321369002777	ABC-ATPase subunit interface; other site
1321369002778	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1321369002779	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1321369002780	active site
1321369002781	HIGH motif; other site
1321369002782	dimer interface [polypeptide binding]; other site
1321369002783	KMSKS motif; other site
1321369002784	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1321369002785	ArsC family; Region: ArsC; pfam03960
1321369002786	putative catalytic residues [active]
1321369002787	thiol/disulfide switch; other site
1321369002788	adaptor protein; Provisional; Region: PRK02315
1321369002789	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1321369002790	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1321369002791	active site
1321369002792	Zn binding site [ion binding]; other site
1321369002793	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1321369002794	Thioredoxin; Region: Thioredoxin_5; pfam13743
1321369002795	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1321369002796	apolar tunnel; other site
1321369002797	heme binding site [chemical binding]; other site
1321369002798	dimerization interface [polypeptide binding]; other site
1321369002799	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1321369002800	putative active site [active]
1321369002801	putative metal binding residues [ion binding]; other site
1321369002802	signature motif; other site
1321369002803	putative triphosphate binding site [ion binding]; other site
1321369002804	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1321369002805	synthetase active site [active]
1321369002806	NTP binding site [chemical binding]; other site
1321369002807	metal binding site [ion binding]; metal-binding site
1321369002808	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1321369002809	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1321369002810	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1321369002811	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1321369002812	active site
1321369002813	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1321369002814	MgtE intracellular N domain; Region: MgtE_N; smart00924
1321369002815	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1321369002816	Divalent cation transporter; Region: MgtE; pfam01769
1321369002817	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1321369002818	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1321369002819	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1321369002820	TrkA-N domain; Region: TrkA_N; pfam02254
1321369002821	TrkA-C domain; Region: TrkA_C; pfam02080
1321369002822	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1321369002823	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1321369002824	NAD binding site [chemical binding]; other site
1321369002825	homotetramer interface [polypeptide binding]; other site
1321369002826	homodimer interface [polypeptide binding]; other site
1321369002827	substrate binding site [chemical binding]; other site
1321369002828	active site
1321369002829	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1321369002830	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1321369002831	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1321369002832	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1321369002833	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1321369002834	Putative esterase; Region: Esterase; pfam00756
1321369002835	hypothetical protein; Provisional; Region: PRK13679
1321369002836	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1321369002837	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369002838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369002839	putative substrate translocation pore; other site
1321369002840	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1321369002841	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1321369002842	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1321369002843	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1321369002844	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1321369002845	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1321369002846	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1321369002847	YueH-like protein; Region: YueH; pfam14166
1321369002848	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1321369002849	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1321369002850	G1 box; other site
1321369002851	putative GEF interaction site [polypeptide binding]; other site
1321369002852	GTP/Mg2+ binding site [chemical binding]; other site
1321369002853	Switch I region; other site
1321369002854	G2 box; other site
1321369002855	G3 box; other site
1321369002856	Switch II region; other site
1321369002857	G4 box; other site
1321369002858	G5 box; other site
1321369002859	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1321369002860	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1321369002861	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1321369002862	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1321369002863	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1321369002864	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1321369002865	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1321369002866	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1321369002867	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1321369002868	active site
1321369002869	metal binding site [ion binding]; metal-binding site
1321369002870	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1321369002871	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1321369002872	IDEAL domain; Region: IDEAL; pfam08858
1321369002873	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1321369002874	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1321369002875	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1321369002876	CAAX protease self-immunity; Region: Abi; pfam02517
1321369002877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1321369002878	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1321369002879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1321369002880	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1321369002881	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1321369002882	Walker A/P-loop; other site
1321369002883	ATP binding site [chemical binding]; other site
1321369002884	Q-loop/lid; other site
1321369002885	ABC transporter signature motif; other site
1321369002886	Walker B; other site
1321369002887	D-loop; other site
1321369002888	H-loop/switch region; other site
1321369002889	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1321369002890	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1321369002891	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1321369002892	Predicted membrane protein [Function unknown]; Region: COG2259
1321369002893	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1321369002894	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1321369002895	siderophore binding site; other site
1321369002896	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1321369002897	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369002898	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369002899	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369002900	Coenzyme A binding pocket [chemical binding]; other site
1321369002901	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1321369002902	UbiA prenyltransferase family; Region: UbiA; pfam01040
1321369002903	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1321369002904	isochorismate synthases; Region: isochor_syn; TIGR00543
1321369002905	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1321369002906	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1321369002907	dimer interface [polypeptide binding]; other site
1321369002908	tetramer interface [polypeptide binding]; other site
1321369002909	PYR/PP interface [polypeptide binding]; other site
1321369002910	TPP binding site [chemical binding]; other site
1321369002911	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1321369002912	TPP-binding site; other site
1321369002913	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1321369002914	PGAP1-like protein; Region: PGAP1; pfam07819
1321369002915	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1321369002916	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1321369002917	substrate binding site [chemical binding]; other site
1321369002918	oxyanion hole (OAH) forming residues; other site
1321369002919	trimer interface [polypeptide binding]; other site
1321369002920	Staphostatin B; Region: Staphostatin_B; pfam09023
1321369002921	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1321369002922	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369002923	aminotransferase A; Validated; Region: PRK07683
1321369002924	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1321369002925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369002926	homodimer interface [polypeptide binding]; other site
1321369002927	catalytic residue [active]
1321369002928	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369002929	MarR family; Region: MarR; pfam01047
1321369002930	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1321369002931	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1321369002932	amidase catalytic site [active]
1321369002933	Zn binding residues [ion binding]; other site
1321369002934	substrate binding site [chemical binding]; other site
1321369002935	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1321369002936	Lysozyme subfamily 2; Region: LYZ2; smart00047
1321369002937	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369002938	Coenzyme A binding pocket [chemical binding]; other site
1321369002939	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1321369002940	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1321369002941	Beta-lactamase; Region: Beta-lactamase; pfam00144
1321369002942	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1321369002943	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
1321369002944	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1321369002945	Subunit I/III interface [polypeptide binding]; other site
1321369002946	Subunit III/IV interface [polypeptide binding]; other site
1321369002947	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1321369002948	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1321369002949	D-pathway; other site
1321369002950	Putative ubiquinol binding site [chemical binding]; other site
1321369002951	Low-spin heme (heme b) binding site [chemical binding]; other site
1321369002952	Putative water exit pathway; other site
1321369002953	Binuclear center (heme o3/CuB) [ion binding]; other site
1321369002954	K-pathway; other site
1321369002955	Putative proton exit pathway; other site
1321369002956	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1321369002957	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1321369002958	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1321369002959	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1321369002960	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
1321369002961	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1321369002962	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1321369002963	homodimer interface [polypeptide binding]; other site
1321369002964	NADP binding site [chemical binding]; other site
1321369002965	substrate binding site [chemical binding]; other site
1321369002966	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1321369002967	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1321369002968	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1321369002969	NAD binding site [chemical binding]; other site
1321369002970	ATP-grasp domain; Region: ATP-grasp; pfam02222
1321369002971	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1321369002972	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1321369002973	ATP binding site [chemical binding]; other site
1321369002974	active site
1321369002975	substrate binding site [chemical binding]; other site
1321369002976	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
1321369002977	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1321369002978	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1321369002979	putative active site [active]
1321369002980	catalytic triad [active]
1321369002981	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1321369002982	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1321369002983	dimerization interface [polypeptide binding]; other site
1321369002984	ATP binding site [chemical binding]; other site
1321369002985	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1321369002986	dimerization interface [polypeptide binding]; other site
1321369002987	ATP binding site [chemical binding]; other site
1321369002988	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1321369002989	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1321369002990	active site
1321369002991	tetramer interface [polypeptide binding]; other site
1321369002992	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369002993	active site
1321369002994	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1321369002995	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1321369002996	dimerization interface [polypeptide binding]; other site
1321369002997	putative ATP binding site [chemical binding]; other site
1321369002998	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1321369002999	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1321369003000	active site
1321369003001	substrate binding site [chemical binding]; other site
1321369003002	cosubstrate binding site; other site
1321369003003	catalytic site [active]
1321369003004	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1321369003005	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1321369003006	purine monophosphate binding site [chemical binding]; other site
1321369003007	dimer interface [polypeptide binding]; other site
1321369003008	putative catalytic residues [active]
1321369003009	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1321369003010	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1321369003011	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1321369003012	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
1321369003013	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1321369003014	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1321369003015	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1321369003016	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1321369003017	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369003018	Walker A/P-loop; other site
1321369003019	ATP binding site [chemical binding]; other site
1321369003020	Q-loop/lid; other site
1321369003021	ABC transporter signature motif; other site
1321369003022	Walker B; other site
1321369003023	D-loop; other site
1321369003024	H-loop/switch region; other site
1321369003025	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1321369003026	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369003027	Walker A/P-loop; other site
1321369003028	ATP binding site [chemical binding]; other site
1321369003029	Q-loop/lid; other site
1321369003030	ABC transporter signature motif; other site
1321369003031	Walker B; other site
1321369003032	D-loop; other site
1321369003033	H-loop/switch region; other site
1321369003034	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1321369003035	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1321369003036	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1321369003037	putative RNA binding site [nucleotide binding]; other site
1321369003038	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1321369003039	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1321369003040	dimerization domain swap beta strand [polypeptide binding]; other site
1321369003041	regulatory protein interface [polypeptide binding]; other site
1321369003042	active site
1321369003043	regulatory phosphorylation site [posttranslational modification]; other site
1321369003044	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1321369003045	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1321369003046	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1321369003047	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1321369003048	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1321369003049	catalytic residues [active]
1321369003050	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1321369003051	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1321369003052	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1321369003053	TrkA-N domain; Region: TrkA_N; pfam02254
1321369003054	TrkA-C domain; Region: TrkA_C; pfam02080
1321369003055	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1321369003056	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1321369003057	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1321369003058	hypothetical protein; Provisional; Region: PRK13667
1321369003059	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1321369003060	active site
1321369003061	catalytic residues [active]
1321369003062	metal binding site [ion binding]; metal-binding site
1321369003063	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1321369003064	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1321369003065	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1321369003066	TPP-binding site [chemical binding]; other site
1321369003067	tetramer interface [polypeptide binding]; other site
1321369003068	heterodimer interface [polypeptide binding]; other site
1321369003069	phosphorylation loop region [posttranslational modification]
1321369003070	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1321369003071	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1321369003072	alpha subunit interface [polypeptide binding]; other site
1321369003073	TPP binding site [chemical binding]; other site
1321369003074	heterodimer interface [polypeptide binding]; other site
1321369003075	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1321369003076	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1321369003077	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1321369003078	E3 interaction surface; other site
1321369003079	lipoyl attachment site [posttranslational modification]; other site
1321369003080	e3 binding domain; Region: E3_binding; pfam02817
1321369003081	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1321369003082	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1321369003083	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1321369003084	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369003085	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1321369003086	hypothetical protein; Provisional; Region: PRK04387
1321369003087	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369003088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369003089	non-specific DNA binding site [nucleotide binding]; other site
1321369003090	salt bridge; other site
1321369003091	sequence-specific DNA binding site [nucleotide binding]; other site
1321369003092	Cupin domain; Region: Cupin_2; pfam07883
1321369003093	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1321369003094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369003095	Walker A/P-loop; other site
1321369003096	ATP binding site [chemical binding]; other site
1321369003097	Q-loop/lid; other site
1321369003098	ABC transporter signature motif; other site
1321369003099	Walker B; other site
1321369003100	D-loop; other site
1321369003101	H-loop/switch region; other site
1321369003102	TOBE domain; Region: TOBE_2; pfam08402
1321369003103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369003104	putative PBP binding loops; other site
1321369003105	dimer interface [polypeptide binding]; other site
1321369003106	ABC-ATPase subunit interface; other site
1321369003107	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1321369003108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369003109	dimer interface [polypeptide binding]; other site
1321369003110	conserved gate region; other site
1321369003111	putative PBP binding loops; other site
1321369003112	ABC-ATPase subunit interface; other site
1321369003113	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1321369003114	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
1321369003115	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1321369003116	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1321369003117	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1321369003118	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1321369003119	manganese transport protein MntH; Reviewed; Region: PRK00701
1321369003120	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1321369003121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1321369003122	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1321369003123	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1321369003124	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1321369003125	active site
1321369003126	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1321369003127	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1321369003128	G1 box; other site
1321369003129	putative GEF interaction site [polypeptide binding]; other site
1321369003130	GTP/Mg2+ binding site [chemical binding]; other site
1321369003131	Switch I region; other site
1321369003132	G2 box; other site
1321369003133	G3 box; other site
1321369003134	Switch II region; other site
1321369003135	G4 box; other site
1321369003136	G5 box; other site
1321369003137	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1321369003138	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1321369003139	hypothetical protein; Provisional; Region: PRK13666
1321369003140	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1321369003141	pyruvate carboxylase; Reviewed; Region: PRK12999
1321369003142	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1321369003143	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1321369003144	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1321369003145	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1321369003146	active site
1321369003147	catalytic residues [active]
1321369003148	metal binding site [ion binding]; metal-binding site
1321369003149	homodimer binding site [polypeptide binding]; other site
1321369003150	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1321369003151	carboxyltransferase (CT) interaction site; other site
1321369003152	biotinylation site [posttranslational modification]; other site
1321369003153	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1321369003154	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1321369003155	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1321369003156	UbiA prenyltransferase family; Region: UbiA; pfam01040
1321369003157	Predicted membrane protein [Function unknown]; Region: COG2322
1321369003158	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1321369003159	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1321369003160	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
1321369003161	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1321369003162	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1321369003163	putative active site [active]
1321369003164	catalytic site [active]
1321369003165	putative metal binding site [ion binding]; other site
1321369003166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
1321369003167	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1321369003168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369003169	S-adenosylmethionine binding site [chemical binding]; other site
1321369003170	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1321369003171	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1321369003172	active site
1321369003173	(T/H)XGH motif; other site
1321369003174	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1321369003175	hypothetical protein; Provisional; Region: PRK13670
1321369003176	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1321369003177	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1321369003178	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1321369003179	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1321369003180	catalytic residues [active]
1321369003181	catalytic nucleophile [active]
1321369003182	Presynaptic Site I dimer interface [polypeptide binding]; other site
1321369003183	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1321369003184	Synaptic Flat tetramer interface [polypeptide binding]; other site
1321369003185	Synaptic Site I dimer interface [polypeptide binding]; other site
1321369003186	DNA binding site [nucleotide binding]
1321369003187	Recombinase; Region: Recombinase; pfam07508
1321369003188	PemK-like protein; Region: PemK; pfam02452
1321369003189	Short C-terminal domain; Region: SHOCT; pfam09851
1321369003190	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1321369003191	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369003192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369003193	sequence-specific DNA binding site [nucleotide binding]; other site
1321369003194	salt bridge; other site
1321369003195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369003196	non-specific DNA binding site [nucleotide binding]; other site
1321369003197	salt bridge; other site
1321369003198	sequence-specific DNA binding site [nucleotide binding]; other site
1321369003199	BRO family, N-terminal domain; Region: Bro-N; smart01040
1321369003200	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
1321369003201	Phage anti-repressor protein [Transcription]; Region: COG3561
1321369003202	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
1321369003203	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
1321369003204	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352
1321369003205	ERF superfamily; Region: ERF; pfam04404
1321369003206	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1321369003207	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1321369003208	ssDNA binding site [nucleotide binding]; other site
1321369003209	dimer interface [polypeptide binding]; other site
1321369003210	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369003211	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1321369003212	Helix-turn-helix domain; Region: HTH_36; pfam13730
1321369003213	phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220
1321369003214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369003215	Walker A motif; other site
1321369003216	ATP binding site [chemical binding]; other site
1321369003217	Walker B motif; other site
1321369003218	Protein of unknown function (DUF3269); Region: DUF3269; pfam11673
1321369003219	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
1321369003220	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
1321369003221	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
1321369003222	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
1321369003223	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1321369003224	trimer interface [polypeptide binding]; other site
1321369003225	active site
1321369003226	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
1321369003227	Virulence-associated protein E; Region: VirE; pfam05272
1321369003228	VRR-NUC domain; Region: VRR_NUC; pfam08774
1321369003229	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1321369003230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369003231	ATP binding site [chemical binding]; other site
1321369003232	putative Mg++ binding site [ion binding]; other site
1321369003233	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1321369003234	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1321369003235	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1321369003236	active site
1321369003237	Phage terminase, small subunit; Region: Terminase_4; pfam05119
1321369003238	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1321369003239	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1321369003240	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1321369003241	Clp protease; Region: CLP_protease; pfam00574
1321369003242	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1321369003243	oligomer interface [polypeptide binding]; other site
1321369003244	active site residues [active]
1321369003245	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1321369003246	Phage capsid family; Region: Phage_capsid; pfam05065
1321369003247	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1321369003248	oligomerization interface [polypeptide binding]; other site
1321369003249	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1321369003250	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1321369003251	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1321369003252	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
1321369003253	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
1321369003254	linker region; other site
1321369003255	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1321369003256	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1321369003257	dimer interface [polypeptide binding]; other site
1321369003258	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1321369003259	Peptidase family M23; Region: Peptidase_M23; pfam01551
1321369003260	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1321369003261	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1321369003262	catalytic residue [active]
1321369003263	Phage tail protein; Region: Sipho_tail; pfam05709
1321369003264	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
1321369003265	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1321369003266	hypothetical protein; Provisional; Region: PRK05926
1321369003267	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
1321369003268	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
1321369003269	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
1321369003270	holin, SPP1 family; Region: holin_SPP1; TIGR01592
1321369003271	CHAP domain; Region: CHAP; pfam05257
1321369003272	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1321369003273	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1321369003274	active site
1321369003275	metal binding site [ion binding]; metal-binding site
1321369003276	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1321369003277	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1321369003278	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1321369003279	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1321369003280	Predicted membrane protein [Function unknown]; Region: COG3601
1321369003281	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1321369003282	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1321369003283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1321369003284	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1321369003285	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369003286	ATP binding site [chemical binding]; other site
1321369003287	putative Mg++ binding site [ion binding]; other site
1321369003288	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369003289	nucleotide binding region [chemical binding]; other site
1321369003290	ATP-binding site [chemical binding]; other site
1321369003291	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369003292	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1321369003293	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1321369003294	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369003295	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1321369003296	active site
1321369003297	homotetramer interface [polypeptide binding]; other site
1321369003298	homodimer interface [polypeptide binding]; other site
1321369003299	cytidylate kinase; Provisional; Region: cmk; PRK00023
1321369003300	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1321369003301	CMP-binding site; other site
1321369003302	The sites determining sugar specificity; other site
1321369003303	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1321369003304	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1321369003305	RNA binding site [nucleotide binding]; other site
1321369003306	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1321369003307	RNA binding site [nucleotide binding]; other site
1321369003308	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1321369003309	RNA binding site [nucleotide binding]; other site
1321369003310	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1321369003311	RNA binding site [nucleotide binding]; other site
1321369003312	GTP-binding protein Der; Reviewed; Region: PRK00093
1321369003313	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1321369003314	G1 box; other site
1321369003315	GTP/Mg2+ binding site [chemical binding]; other site
1321369003316	Switch I region; other site
1321369003317	G2 box; other site
1321369003318	Switch II region; other site
1321369003319	G3 box; other site
1321369003320	G4 box; other site
1321369003321	G5 box; other site
1321369003322	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1321369003323	G1 box; other site
1321369003324	GTP/Mg2+ binding site [chemical binding]; other site
1321369003325	Switch I region; other site
1321369003326	G2 box; other site
1321369003327	G3 box; other site
1321369003328	Switch II region; other site
1321369003329	G4 box; other site
1321369003330	G5 box; other site
1321369003331	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1321369003332	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1321369003333	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1321369003334	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1321369003335	IHF dimer interface [polypeptide binding]; other site
1321369003336	IHF - DNA interface [nucleotide binding]; other site
1321369003337	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1321369003338	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1321369003339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369003340	S-adenosylmethionine binding site [chemical binding]; other site
1321369003341	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1321369003342	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1321369003343	substrate binding pocket [chemical binding]; other site
1321369003344	chain length determination region; other site
1321369003345	substrate-Mg2+ binding site; other site
1321369003346	catalytic residues [active]
1321369003347	aspartate-rich region 1; other site
1321369003348	active site lid residues [active]
1321369003349	aspartate-rich region 2; other site
1321369003350	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1321369003351	active site
1321369003352	multimer interface [polypeptide binding]; other site
1321369003353	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1321369003354	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1321369003355	Tetramer interface [polypeptide binding]; other site
1321369003356	active site
1321369003357	FMN-binding site [chemical binding]; other site
1321369003358	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1321369003359	active site
1321369003360	NAD binding site [chemical binding]; other site
1321369003361	metal binding site [ion binding]; metal-binding site
1321369003362	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1321369003363	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1321369003364	hinge; other site
1321369003365	active site
1321369003366	TPR repeat; Region: TPR_11; pfam13414
1321369003367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1321369003368	binding surface
1321369003369	TPR motif; other site
1321369003370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1321369003371	TPR motif; other site
1321369003372	binding surface
1321369003373	Uncharacterized conserved protein [Function unknown]; Region: COG5582
1321369003374	UPF0302 domain; Region: UPF0302; pfam08864
1321369003375	A short protein domain of unknown function; Region: IDEAL; smart00914
1321369003376	Predicted membrane protein [Function unknown]; Region: COG4347
1321369003377	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1321369003378	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1321369003379	homodimer interface [polypeptide binding]; other site
1321369003380	metal binding site [ion binding]; metal-binding site
1321369003381	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1321369003382	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1321369003383	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1321369003384	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1321369003385	active site
1321369003386	NTP binding site [chemical binding]; other site
1321369003387	metal binding triad [ion binding]; metal-binding site
1321369003388	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1321369003389	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1321369003390	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1321369003391	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1321369003392	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1321369003393	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1321369003394	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1321369003395	active site
1321369003396	catalytic site [active]
1321369003397	substrate binding site [chemical binding]; other site
1321369003398	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1321369003399	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1321369003400	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1321369003401	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1321369003402	putative dimer interface [polypeptide binding]; other site
1321369003403	putative anticodon binding site; other site
1321369003404	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1321369003405	homodimer interface [polypeptide binding]; other site
1321369003406	motif 1; other site
1321369003407	motif 2; other site
1321369003408	active site
1321369003409	motif 3; other site
1321369003410	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1321369003411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1321369003412	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1321369003413	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1321369003414	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1321369003415	minor groove reading motif; other site
1321369003416	helix-hairpin-helix signature motif; other site
1321369003417	substrate binding pocket [chemical binding]; other site
1321369003418	active site
1321369003419	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1321369003420	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1321369003421	Transglycosylase; Region: Transgly; pfam00912
1321369003422	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1321369003423	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1321369003424	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1321369003425	hypothetical protein; Provisional; Region: PRK13660
1321369003426	cell division protein GpsB; Provisional; Region: PRK14127
1321369003427	DivIVA domain; Region: DivI1A_domain; TIGR03544
1321369003428	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1321369003429	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1321369003430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1321369003431	Cobalt transport protein component CbiN; Region: CbiN; cl00842
1321369003432	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1321369003433	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1321369003434	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1321369003435	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1321369003436	Dynamin family; Region: Dynamin_N; pfam00350
1321369003437	G1 box; other site
1321369003438	GTP/Mg2+ binding site [chemical binding]; other site
1321369003439	G2 box; other site
1321369003440	Switch I region; other site
1321369003441	G3 box; other site
1321369003442	Switch II region; other site
1321369003443	G4 box; other site
1321369003444	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1321369003445	Dynamin family; Region: Dynamin_N; pfam00350
1321369003446	G1 box; other site
1321369003447	GTP/Mg2+ binding site [chemical binding]; other site
1321369003448	G2 box; other site
1321369003449	Switch I region; other site
1321369003450	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1321369003451	G3 box; other site
1321369003452	Switch II region; other site
1321369003453	GTP/Mg2+ binding site [chemical binding]; other site
1321369003454	G4 box; other site
1321369003455	G5 box; other site
1321369003456	5'-3' exonuclease; Region: 53EXOc; smart00475
1321369003457	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1321369003458	active site
1321369003459	metal binding site 1 [ion binding]; metal-binding site
1321369003460	putative 5' ssDNA interaction site; other site
1321369003461	metal binding site 3; metal-binding site
1321369003462	metal binding site 2 [ion binding]; metal-binding site
1321369003463	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1321369003464	putative DNA binding site [nucleotide binding]; other site
1321369003465	putative metal binding site [ion binding]; other site
1321369003466	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1321369003467	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1321369003468	hexamer interface [polypeptide binding]; other site
1321369003469	ligand binding site [chemical binding]; other site
1321369003470	putative active site [active]
1321369003471	NAD(P) binding site [chemical binding]; other site
1321369003472	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1321369003473	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1321369003474	tetramer interface [polypeptide binding]; other site
1321369003475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369003476	catalytic residue [active]
1321369003477	Amino acid permease; Region: AA_permease_2; pfam13520
1321369003478	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1321369003479	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369003480	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
1321369003481	GA module; Region: GA; smart00844
1321369003482	GA module; Region: GA; smart00844
1321369003483	GA module; Region: GA; smart00844
1321369003484	GA module; Region: GA; smart00844
1321369003485	GA module; Region: GA; smart00844
1321369003486	GA module; Region: GA; smart00844
1321369003487	GA module; Region: GA; smart00844
1321369003488	GA module; Region: GA; smart00844
1321369003489	GA module; Region: GA; smart00844
1321369003490	GA module; Region: GA; smart00844
1321369003491	GA module; Region: GA; smart00844
1321369003492	GA module; Region: GA; smart00844
1321369003493	GA module; Region: GA; smart00844
1321369003494	GA module; Region: GA; smart00844
1321369003495	GA module; Region: GA; smart00844
1321369003496	GA module; Region: GA; smart00844
1321369003497	GA module; Region: GA; smart00844
1321369003498	GA module; Region: GA; smart00844
1321369003499	GA module; Region: GA; smart00844
1321369003500	GA module; Region: GA; pfam01468
1321369003501	GA module; Region: GA; smart00844
1321369003502	GA module; Region: GA; smart00844
1321369003503	GA module; Region: GA; smart00844
1321369003504	GA module; Region: GA; smart00844
1321369003505	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
1321369003506	GA module; Region: GA; smart00844
1321369003507	GA module; Region: GA; smart00844
1321369003508	GA module; Region: GA; smart00844
1321369003509	GA module; Region: GA; smart00844
1321369003510	GA module; Region: GA; smart00844
1321369003511	GA module; Region: GA; smart00844
1321369003512	GA module; Region: GA; smart00844
1321369003513	GA module; Region: GA; pfam01468
1321369003514	GA module; Region: GA; smart00844
1321369003515	GA module; Region: GA; smart00844
1321369003516	GA module; Region: GA; smart00844
1321369003517	GA module; Region: GA; smart00844
1321369003518	GA module; Region: GA; smart00844
1321369003519	GA module; Region: GA; smart00844
1321369003520	GA module; Region: GA; smart00844
1321369003521	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1321369003522	GA module; Region: GA; smart00844
1321369003523	GA module; Region: GA; smart00844
1321369003524	GA module; Region: GA; smart00844
1321369003525	GA module; Region: GA; smart00844
1321369003526	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369003527	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369003528	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1321369003529	RNA/DNA hybrid binding site [nucleotide binding]; other site
1321369003530	active site
1321369003531	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1321369003532	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1321369003533	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
1321369003534	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1321369003535	Virulence factor; Region: Virulence_fact; pfam13769
1321369003536	HEAT repeats; Region: HEAT_2; pfam13646
1321369003537	HEAT repeat; Region: HEAT; pfam02985
1321369003538	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1321369003539	thymidylate synthase; Region: thym_sym; TIGR03284
1321369003540	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1321369003541	dimerization interface [polypeptide binding]; other site
1321369003542	active site
1321369003543	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1321369003544	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1321369003545	folate binding site [chemical binding]; other site
1321369003546	NADP+ binding site [chemical binding]; other site
1321369003547	EDD domain protein, DegV family; Region: DegV; TIGR00762
1321369003548	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1321369003549	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1321369003550	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1321369003551	SelR domain; Region: SelR; pfam01641
1321369003552	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1321369003553	HPr interaction site; other site
1321369003554	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1321369003555	active site
1321369003556	phosphorylation site [posttranslational modification]
1321369003557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
1321369003558	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1321369003559	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1321369003560	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1321369003561	protein binding site [polypeptide binding]; other site
1321369003562	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1321369003563	Catalytic dyad [active]
1321369003564	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1321369003565	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369003566	Coenzyme A binding pocket [chemical binding]; other site
1321369003567	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1321369003568	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1321369003569	active site
1321369003570	homodimer interface [polypeptide binding]; other site
1321369003571	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1321369003572	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1321369003573	active site
1321369003574	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1321369003575	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369003576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369003577	active site
1321369003578	phosphorylation site [posttranslational modification]
1321369003579	intermolecular recognition site; other site
1321369003580	dimerization interface [polypeptide binding]; other site
1321369003581	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369003582	DNA binding site [nucleotide binding]
1321369003583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1321369003584	HAMP domain; Region: HAMP; pfam00672
1321369003585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369003586	dimer interface [polypeptide binding]; other site
1321369003587	phosphorylation site [posttranslational modification]
1321369003588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369003589	ATP binding site [chemical binding]; other site
1321369003590	Mg2+ binding site [ion binding]; other site
1321369003591	G-X-G motif; other site
1321369003592	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1321369003593	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1321369003594	TPP-binding site [chemical binding]; other site
1321369003595	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
1321369003596	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1321369003597	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1321369003598	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1321369003599	E3 interaction surface; other site
1321369003600	lipoyl attachment site [posttranslational modification]; other site
1321369003601	e3 binding domain; Region: E3_binding; pfam02817
1321369003602	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1321369003603	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1321369003604	active site
1321369003605	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1321369003606	active site
1321369003607	MoxR-like ATPases [General function prediction only]; Region: COG0714
1321369003608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369003609	Walker A motif; other site
1321369003610	ATP binding site [chemical binding]; other site
1321369003611	Walker B motif; other site
1321369003612	arginine finger; other site
1321369003613	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1321369003614	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1321369003615	metal ion-dependent adhesion site (MIDAS); other site
1321369003616	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
1321369003617	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369003618	MULE transposase domain; Region: MULE; pfam10551
1321369003619	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369003620	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1321369003621	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1321369003622	acylphosphatase; Provisional; Region: PRK14431
1321369003623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
1321369003624	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1321369003625	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1321369003626	active site
1321369003627	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1321369003628	substrate binding site [chemical binding]; other site
1321369003629	catalytic residues [active]
1321369003630	dimer interface [polypeptide binding]; other site
1321369003631	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1321369003632	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1321369003633	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1321369003634	catalytic residue [active]
1321369003635	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1321369003636	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1321369003637	metal binding site [ion binding]; metal-binding site
1321369003638	dimer interface [polypeptide binding]; other site
1321369003639	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1321369003640	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1321369003641	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1321369003642	active site
1321369003643	trimer interface [polypeptide binding]; other site
1321369003644	substrate binding site [chemical binding]; other site
1321369003645	CoA binding site [chemical binding]; other site
1321369003646	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1321369003647	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1321369003648	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1321369003649	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1321369003650	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1321369003651	dimer interface [polypeptide binding]; other site
1321369003652	active site
1321369003653	catalytic residue [active]
1321369003654	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1321369003655	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1321369003656	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1321369003657	aspartate kinase; Reviewed; Region: PRK06635
1321369003658	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1321369003659	putative nucleotide binding site [chemical binding]; other site
1321369003660	putative catalytic residues [active]
1321369003661	putative Mg ion binding site [ion binding]; other site
1321369003662	putative aspartate binding site [chemical binding]; other site
1321369003663	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
1321369003664	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1321369003665	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1321369003666	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1321369003667	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369003668	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369003669	ABC transporter; Region: ABC_tran_2; pfam12848
1321369003670	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369003671	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1321369003672	S1 domain; Region: S1_2; pfam13509
1321369003673	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369003674	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369003675	phosphate binding protein; Region: ptsS_2; TIGR02136
1321369003676	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1321369003677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369003678	dimer interface [polypeptide binding]; other site
1321369003679	conserved gate region; other site
1321369003680	ABC-ATPase subunit interface; other site
1321369003681	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1321369003682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369003683	dimer interface [polypeptide binding]; other site
1321369003684	conserved gate region; other site
1321369003685	putative PBP binding loops; other site
1321369003686	ABC-ATPase subunit interface; other site
1321369003687	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1321369003688	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1321369003689	Walker A/P-loop; other site
1321369003690	ATP binding site [chemical binding]; other site
1321369003691	Q-loop/lid; other site
1321369003692	ABC transporter signature motif; other site
1321369003693	Walker B; other site
1321369003694	D-loop; other site
1321369003695	H-loop/switch region; other site
1321369003696	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1321369003697	PhoU domain; Region: PhoU; pfam01895
1321369003698	PhoU domain; Region: PhoU; pfam01895
1321369003699	oligoendopeptidase F; Region: pepF; TIGR00181
1321369003700	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1321369003701	active site
1321369003702	Zn binding site [ion binding]; other site
1321369003703	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
1321369003704	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1321369003705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369003706	dimer interface [polypeptide binding]; other site
1321369003707	conserved gate region; other site
1321369003708	putative PBP binding loops; other site
1321369003709	ABC-ATPase subunit interface; other site
1321369003710	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1321369003711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369003712	dimer interface [polypeptide binding]; other site
1321369003713	conserved gate region; other site
1321369003714	putative PBP binding loops; other site
1321369003715	ABC-ATPase subunit interface; other site
1321369003716	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369003717	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1321369003718	Walker A/P-loop; other site
1321369003719	ATP binding site [chemical binding]; other site
1321369003720	Q-loop/lid; other site
1321369003721	ABC transporter signature motif; other site
1321369003722	Walker B; other site
1321369003723	D-loop; other site
1321369003724	H-loop/switch region; other site
1321369003725	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1321369003726	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369003727	Walker A/P-loop; other site
1321369003728	ATP binding site [chemical binding]; other site
1321369003729	Q-loop/lid; other site
1321369003730	ABC transporter signature motif; other site
1321369003731	Walker B; other site
1321369003732	D-loop; other site
1321369003733	H-loop/switch region; other site
1321369003734	SWIM zinc finger; Region: SWIM; pfam04434
1321369003735	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1321369003736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369003737	active site
1321369003738	motif I; other site
1321369003739	motif II; other site
1321369003740	FemAB family; Region: FemAB; pfam02388
1321369003741	FemAB family; Region: FemAB; pfam02388
1321369003742	FlxA-like protein; Region: FlxA; pfam14282
1321369003743	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1321369003744	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1321369003745	substrate binding site [chemical binding]; other site
1321369003746	active site
1321369003747	catalytic residues [active]
1321369003748	heterodimer interface [polypeptide binding]; other site
1321369003749	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1321369003750	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1321369003751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369003752	catalytic residue [active]
1321369003753	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1321369003754	active site
1321369003755	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1321369003756	active site
1321369003757	ribulose/triose binding site [chemical binding]; other site
1321369003758	phosphate binding site [ion binding]; other site
1321369003759	substrate (anthranilate) binding pocket [chemical binding]; other site
1321369003760	product (indole) binding pocket [chemical binding]; other site
1321369003761	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1321369003762	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1321369003763	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1321369003764	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1321369003765	glutamine binding [chemical binding]; other site
1321369003766	catalytic triad [active]
1321369003767	anthranilate synthase component I; Provisional; Region: PRK13567
1321369003768	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1321369003769	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1321369003770	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1321369003771	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1321369003772	putative oligomer interface [polypeptide binding]; other site
1321369003773	putative active site [active]
1321369003774	metal binding site [ion binding]; metal-binding site
1321369003775	prephenate dehydrogenase; Validated; Region: PRK06545
1321369003776	prephenate dehydrogenase; Validated; Region: PRK08507
1321369003777	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1321369003778	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1321369003779	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1321369003780	active site
1321369003781	DNA binding site [nucleotide binding]
1321369003782	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1321369003783	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1321369003784	active site 1 [active]
1321369003785	dimer interface [polypeptide binding]; other site
1321369003786	hexamer interface [polypeptide binding]; other site
1321369003787	active site 2 [active]
1321369003788	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1321369003789	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1321369003790	Predicted integral membrane protein [Function unknown]; Region: COG0392
1321369003791	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1321369003792	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1321369003793	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1321369003794	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1321369003795	CAT RNA binding domain; Region: CAT_RBD; smart01061
1321369003796	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1321369003797	PRD domain; Region: PRD; pfam00874
1321369003798	PRD domain; Region: PRD; pfam00874
1321369003799	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1321369003800	amino acid carrier protein; Region: agcS; TIGR00835
1321369003801	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1321369003802	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1321369003803	CAP-like domain; other site
1321369003804	active site
1321369003805	primary dimer interface [polypeptide binding]; other site
1321369003806	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1321369003807	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1321369003808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369003809	ATP binding site [chemical binding]; other site
1321369003810	Mg2+ binding site [ion binding]; other site
1321369003811	G-X-G motif; other site
1321369003812	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1321369003813	anchoring element; other site
1321369003814	dimer interface [polypeptide binding]; other site
1321369003815	ATP binding site [chemical binding]; other site
1321369003816	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1321369003817	active site
1321369003818	putative metal-binding site [ion binding]; other site
1321369003819	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1321369003820	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1321369003821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1321369003822	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1321369003823	active site
1321369003824	aconitate hydratase; Validated; Region: PRK09277
1321369003825	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1321369003826	substrate binding site [chemical binding]; other site
1321369003827	ligand binding site [chemical binding]; other site
1321369003828	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1321369003829	substrate binding site [chemical binding]; other site
1321369003830	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1321369003831	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1321369003832	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
1321369003833	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1321369003834	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1321369003835	Walker A/P-loop; other site
1321369003836	ATP binding site [chemical binding]; other site
1321369003837	Q-loop/lid; other site
1321369003838	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1321369003839	ABC transporter signature motif; other site
1321369003840	Walker B; other site
1321369003841	D-loop; other site
1321369003842	H-loop/switch region; other site
1321369003843	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1321369003844	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1321369003845	active site
1321369003846	metal binding site [ion binding]; metal-binding site
1321369003847	DNA binding site [nucleotide binding]
1321369003848	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1321369003849	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1321369003850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1321369003851	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1321369003852	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1321369003853	TPP-binding site [chemical binding]; other site
1321369003854	dimer interface [polypeptide binding]; other site
1321369003855	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1321369003856	PYR/PP interface [polypeptide binding]; other site
1321369003857	dimer interface [polypeptide binding]; other site
1321369003858	TPP binding site [chemical binding]; other site
1321369003859	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1321369003860	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1321369003861	LexA repressor; Validated; Region: PRK00215
1321369003862	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1321369003863	putative DNA binding site [nucleotide binding]; other site
1321369003864	putative Zn2+ binding site [ion binding]; other site
1321369003865	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1321369003866	Catalytic site [active]
1321369003867	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1321369003868	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1321369003869	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1321369003870	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1321369003871	active site
1321369003872	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1321369003873	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1321369003874	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1321369003875	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1321369003876	tetramer interface [polypeptide binding]; other site
1321369003877	heme binding pocket [chemical binding]; other site
1321369003878	NADPH binding site [chemical binding]; other site
1321369003879	lysine transporter; Provisional; Region: PRK10836
1321369003880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369003881	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1321369003882	active site
1321369003883	motif I; other site
1321369003884	motif II; other site
1321369003885	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1321369003886	homoserine kinase; Provisional; Region: PRK01212
1321369003887	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1321369003888	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1321369003889	threonine synthase; Reviewed; Region: PRK06721
1321369003890	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1321369003891	homodimer interface [polypeptide binding]; other site
1321369003892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369003893	catalytic residue [active]
1321369003894	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1321369003895	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1321369003896	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1321369003897	aspartate kinase; Reviewed; Region: PRK09034
1321369003898	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1321369003899	putative catalytic residues [active]
1321369003900	putative nucleotide binding site [chemical binding]; other site
1321369003901	putative aspartate binding site [chemical binding]; other site
1321369003902	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1321369003903	allosteric regulatory residue; other site
1321369003904	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1321369003905	AAA domain; Region: AAA_11; pfam13086
1321369003906	Staphylococcal nuclease homologues; Region: SNc; smart00318
1321369003907	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1321369003908	Catalytic site; other site
1321369003909	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1321369003910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369003911	active site
1321369003912	phosphorylation site [posttranslational modification]
1321369003913	intermolecular recognition site; other site
1321369003914	dimerization interface [polypeptide binding]; other site
1321369003915	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1321369003916	DNA binding residues [nucleotide binding]
1321369003917	dimerization interface [polypeptide binding]; other site
1321369003918	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369003919	MULE transposase domain; Region: MULE; pfam10551
1321369003920	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1321369003921	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1321369003922	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1321369003923	Walker A/P-loop; other site
1321369003924	ATP binding site [chemical binding]; other site
1321369003925	Q-loop/lid; other site
1321369003926	ABC transporter signature motif; other site
1321369003927	Walker B; other site
1321369003928	D-loop; other site
1321369003929	H-loop/switch region; other site
1321369003930	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1321369003931	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1321369003932	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1321369003933	putative active site [active]
1321369003934	catalytic site [active]
1321369003935	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1321369003936	putative active site [active]
1321369003937	catalytic site [active]
1321369003938	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1321369003939	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1321369003940	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369003941	catalytic residue [active]
1321369003942	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1321369003943	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1321369003944	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1321369003945	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1321369003946	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1321369003947	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1321369003948	DNA binding residues [nucleotide binding]
1321369003949	putative dimer interface [polypeptide binding]; other site
1321369003950	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1321369003951	Aluminium resistance protein; Region: Alum_res; pfam06838
1321369003952	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1321369003953	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1321369003954	HflX GTPase family; Region: HflX; cd01878
1321369003955	G1 box; other site
1321369003956	GTP/Mg2+ binding site [chemical binding]; other site
1321369003957	Switch I region; other site
1321369003958	G2 box; other site
1321369003959	G3 box; other site
1321369003960	Switch II region; other site
1321369003961	G4 box; other site
1321369003962	G5 box; other site
1321369003963	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1321369003964	catalytic residues [active]
1321369003965	dimer interface [polypeptide binding]; other site
1321369003966	bacterial Hfq-like; Region: Hfq; cd01716
1321369003967	hexamer interface [polypeptide binding]; other site
1321369003968	Sm1 motif; other site
1321369003969	RNA binding site [nucleotide binding]; other site
1321369003970	Sm2 motif; other site
1321369003971	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1321369003972	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1321369003973	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1321369003974	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1321369003975	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
1321369003976	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1321369003977	glycerol kinase; Provisional; Region: glpK; PRK00047
1321369003978	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1321369003979	N- and C-terminal domain interface [polypeptide binding]; other site
1321369003980	active site
1321369003981	MgATP binding site [chemical binding]; other site
1321369003982	catalytic site [active]
1321369003983	metal binding site [ion binding]; metal-binding site
1321369003984	glycerol binding site [chemical binding]; other site
1321369003985	homotetramer interface [polypeptide binding]; other site
1321369003986	homodimer interface [polypeptide binding]; other site
1321369003987	FBP binding site [chemical binding]; other site
1321369003988	protein IIAGlc interface [polypeptide binding]; other site
1321369003989	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1321369003990	amphipathic channel; other site
1321369003991	Asn-Pro-Ala signature motifs; other site
1321369003992	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
1321369003993	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1321369003994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369003995	ATP binding site [chemical binding]; other site
1321369003996	Mg2+ binding site [ion binding]; other site
1321369003997	G-X-G motif; other site
1321369003998	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1321369003999	ATP binding site [chemical binding]; other site
1321369004000	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1321369004001	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1321369004002	MutS domain I; Region: MutS_I; pfam01624
1321369004003	MutS domain II; Region: MutS_II; pfam05188
1321369004004	MutS domain III; Region: MutS_III; pfam05192
1321369004005	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1321369004006	Walker A/P-loop; other site
1321369004007	ATP binding site [chemical binding]; other site
1321369004008	Q-loop/lid; other site
1321369004009	ABC transporter signature motif; other site
1321369004010	Walker B; other site
1321369004011	D-loop; other site
1321369004012	H-loop/switch region; other site
1321369004013	Predicted membrane protein [Function unknown]; Region: COG4732
1321369004014	Predicted membrane protein [Function unknown]; Region: COG4550
1321369004015	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1321369004016	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1321369004017	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369004018	FeS/SAM binding site; other site
1321369004019	TRAM domain; Region: TRAM; pfam01938
1321369004020	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1321369004021	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1321369004022	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1321369004023	TPP-binding site [chemical binding]; other site
1321369004024	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1321369004025	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1321369004026	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1321369004027	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1321369004028	dimer interface [polypeptide binding]; other site
1321369004029	PYR/PP interface [polypeptide binding]; other site
1321369004030	TPP binding site [chemical binding]; other site
1321369004031	substrate binding site [chemical binding]; other site
1321369004032	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1321369004033	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1321369004034	putative active site [active]
1321369004035	metal binding site [ion binding]; metal-binding site
1321369004036	homodimer binding site [polypeptide binding]; other site
1321369004037	phosphodiesterase; Provisional; Region: PRK12704
1321369004038	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1321369004039	Zn2+ binding site [ion binding]; other site
1321369004040	Mg2+ binding site [ion binding]; other site
1321369004041	recombinase A; Provisional; Region: recA; PRK09354
1321369004042	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1321369004043	hexamer interface [polypeptide binding]; other site
1321369004044	Walker A motif; other site
1321369004045	ATP binding site [chemical binding]; other site
1321369004046	Walker B motif; other site
1321369004047	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1321369004048	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1321369004049	putative MPT binding site; other site
1321369004050	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1321369004051	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1321369004052	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1321369004053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369004054	non-specific DNA binding site [nucleotide binding]; other site
1321369004055	salt bridge; other site
1321369004056	sequence-specific DNA binding site [nucleotide binding]; other site
1321369004057	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1321369004058	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1321369004059	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1321369004060	classical (c) SDRs; Region: SDR_c; cd05233
1321369004061	NAD(P) binding site [chemical binding]; other site
1321369004062	active site
1321369004063	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1321369004064	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1321369004065	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1321369004066	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1321369004067	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1321369004068	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1321369004069	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1321369004070	DNA-binding site [nucleotide binding]; DNA binding site
1321369004071	UTRA domain; Region: UTRA; pfam07702
1321369004072	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1321369004073	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1321369004074	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1321369004075	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1321369004076	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1321369004077	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1321369004078	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1321369004079	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1321369004080	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1321369004081	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1321369004082	RNase E interface [polypeptide binding]; other site
1321369004083	trimer interface [polypeptide binding]; other site
1321369004084	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1321369004085	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1321369004086	RNase E interface [polypeptide binding]; other site
1321369004087	trimer interface [polypeptide binding]; other site
1321369004088	active site
1321369004089	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1321369004090	putative nucleic acid binding region [nucleotide binding]; other site
1321369004091	G-X-X-G motif; other site
1321369004092	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1321369004093	RNA binding site [nucleotide binding]; other site
1321369004094	domain interface; other site
1321369004095	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1321369004096	16S/18S rRNA binding site [nucleotide binding]; other site
1321369004097	S13e-L30e interaction site [polypeptide binding]; other site
1321369004098	25S rRNA binding site [nucleotide binding]; other site
1321369004099	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
1321369004100	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1321369004101	active site
1321369004102	Riboflavin kinase; Region: Flavokinase; smart00904
1321369004103	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
1321369004104	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1321369004105	RNA binding site [nucleotide binding]; other site
1321369004106	active site
1321369004107	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1321369004108	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1321369004109	translation initiation factor IF-2; Region: IF-2; TIGR00487
1321369004110	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1321369004111	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1321369004112	G1 box; other site
1321369004113	putative GEF interaction site [polypeptide binding]; other site
1321369004114	GTP/Mg2+ binding site [chemical binding]; other site
1321369004115	Switch I region; other site
1321369004116	G2 box; other site
1321369004117	G3 box; other site
1321369004118	Switch II region; other site
1321369004119	G4 box; other site
1321369004120	G5 box; other site
1321369004121	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1321369004122	Translation-initiation factor 2; Region: IF-2; pfam11987
1321369004123	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1321369004124	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1321369004125	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1321369004126	putative RNA binding cleft [nucleotide binding]; other site
1321369004127	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1321369004128	NusA N-terminal domain; Region: NusA_N; pfam08529
1321369004129	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1321369004130	RNA binding site [nucleotide binding]; other site
1321369004131	homodimer interface [polypeptide binding]; other site
1321369004132	NusA-like KH domain; Region: KH_5; pfam13184
1321369004133	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1321369004134	G-X-X-G motif; other site
1321369004135	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1321369004136	Sm and related proteins; Region: Sm_like; cl00259
1321369004137	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1321369004138	putative oligomer interface [polypeptide binding]; other site
1321369004139	putative RNA binding site [nucleotide binding]; other site
1321369004140	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1321369004141	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1321369004142	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1321369004143	generic binding surface II; other site
1321369004144	generic binding surface I; other site
1321369004145	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1321369004146	active site
1321369004147	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1321369004148	active site
1321369004149	catalytic site [active]
1321369004150	substrate binding site [chemical binding]; other site
1321369004151	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1321369004152	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1321369004153	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1321369004154	dimer interface [polypeptide binding]; other site
1321369004155	motif 1; other site
1321369004156	active site
1321369004157	motif 2; other site
1321369004158	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1321369004159	putative deacylase active site [active]
1321369004160	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1321369004161	active site
1321369004162	motif 3; other site
1321369004163	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1321369004164	anticodon binding site; other site
1321369004165	RIP metalloprotease RseP; Region: TIGR00054
1321369004166	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1321369004167	active site
1321369004168	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1321369004169	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1321369004170	protein binding site [polypeptide binding]; other site
1321369004171	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1321369004172	putative substrate binding region [chemical binding]; other site
1321369004173	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1321369004174	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1321369004175	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1321369004176	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1321369004177	catalytic residue [active]
1321369004178	putative FPP diphosphate  binding site; other site
1321369004179	putative FPP binding hydrophobic cleft; other site
1321369004180	dimer interface [polypeptide binding]; other site
1321369004181	putative IPP diphosphate binding site; other site
1321369004182	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1321369004183	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1321369004184	hinge region; other site
1321369004185	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1321369004186	putative nucleotide binding site [chemical binding]; other site
1321369004187	uridine monophosphate binding site [chemical binding]; other site
1321369004188	homohexameric interface [polypeptide binding]; other site
1321369004189	elongation factor Ts; Provisional; Region: tsf; PRK09377
1321369004190	UBA/TS-N domain; Region: UBA; pfam00627
1321369004191	Elongation factor TS; Region: EF_TS; pfam00889
1321369004192	Elongation factor TS; Region: EF_TS; pfam00889
1321369004193	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1321369004194	rRNA interaction site [nucleotide binding]; other site
1321369004195	S8 interaction site; other site
1321369004196	putative laminin-1 binding site; other site
1321369004197	transcriptional repressor CodY; Validated; Region: PRK04158
1321369004198	CodY GAF-like domain; Region: CodY; pfam06018
1321369004199	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1321369004200	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1321369004201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369004202	Walker A motif; other site
1321369004203	ATP binding site [chemical binding]; other site
1321369004204	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1321369004205	Walker B motif; other site
1321369004206	arginine finger; other site
1321369004207	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1321369004208	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1321369004209	active site
1321369004210	HslU subunit interaction site [polypeptide binding]; other site
1321369004211	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1321369004212	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1321369004213	active site
1321369004214	DNA binding site [nucleotide binding]
1321369004215	Int/Topo IB signature motif; other site
1321369004216	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1321369004217	Glucose inhibited division protein A; Region: GIDA; pfam01134
1321369004218	DNA topoisomerase I; Validated; Region: PRK05582
1321369004219	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1321369004220	active site
1321369004221	interdomain interaction site; other site
1321369004222	putative metal-binding site [ion binding]; other site
1321369004223	nucleotide binding site [chemical binding]; other site
1321369004224	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1321369004225	domain I; other site
1321369004226	DNA binding groove [nucleotide binding]
1321369004227	phosphate binding site [ion binding]; other site
1321369004228	domain II; other site
1321369004229	domain III; other site
1321369004230	nucleotide binding site [chemical binding]; other site
1321369004231	catalytic site [active]
1321369004232	domain IV; other site
1321369004233	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1321369004234	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1321369004235	DNA protecting protein DprA; Region: dprA; TIGR00732
1321369004236	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1321369004237	FemAB family; Region: FemAB; pfam02388
1321369004238	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1321369004239	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1321369004240	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1321369004241	CHAP domain; Region: CHAP; pfam05257
1321369004242	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1321369004243	CoA binding domain; Region: CoA_binding; pfam02629
1321369004244	CoA-ligase; Region: Ligase_CoA; pfam00549
1321369004245	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1321369004246	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1321369004247	CoA-ligase; Region: Ligase_CoA; pfam00549
1321369004248	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1321369004249	RNA/DNA hybrid binding site [nucleotide binding]; other site
1321369004250	active site
1321369004251	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1321369004252	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1321369004253	GTP/Mg2+ binding site [chemical binding]; other site
1321369004254	G4 box; other site
1321369004255	G5 box; other site
1321369004256	G1 box; other site
1321369004257	Switch I region; other site
1321369004258	G2 box; other site
1321369004259	G3 box; other site
1321369004260	Switch II region; other site
1321369004261	Predicted membrane protein [Function unknown]; Region: COG4485
1321369004262	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1321369004263	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1321369004264	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1321369004265	RimM N-terminal domain; Region: RimM; pfam01782
1321369004266	PRC-barrel domain; Region: PRC; pfam05239
1321369004267	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1321369004268	signal recognition particle protein; Provisional; Region: PRK10867
1321369004269	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1321369004270	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1321369004271	P loop; other site
1321369004272	GTP binding site [chemical binding]; other site
1321369004273	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1321369004274	putative DNA-binding protein; Validated; Region: PRK00118
1321369004275	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1321369004276	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1321369004277	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1321369004278	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1321369004279	P loop; other site
1321369004280	GTP binding site [chemical binding]; other site
1321369004281	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1321369004282	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1321369004283	Walker A/P-loop; other site
1321369004284	ATP binding site [chemical binding]; other site
1321369004285	Q-loop/lid; other site
1321369004286	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1321369004287	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1321369004288	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1321369004289	ABC transporter signature motif; other site
1321369004290	Walker B; other site
1321369004291	D-loop; other site
1321369004292	H-loop/switch region; other site
1321369004293	ribonuclease III; Reviewed; Region: rnc; PRK00102
1321369004294	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1321369004295	dimerization interface [polypeptide binding]; other site
1321369004296	active site
1321369004297	metal binding site [ion binding]; metal-binding site
1321369004298	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1321369004299	dsRNA binding site [nucleotide binding]; other site
1321369004300	acyl carrier protein; Provisional; Region: acpP; PRK00982
1321369004301	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1321369004302	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1321369004303	NAD(P) binding site [chemical binding]; other site
1321369004304	homotetramer interface [polypeptide binding]; other site
1321369004305	homodimer interface [polypeptide binding]; other site
1321369004306	active site
1321369004307	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1321369004308	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1321369004309	putative phosphate acyltransferase; Provisional; Region: PRK05331
1321369004310	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1321369004311	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1321369004312	active site 2 [active]
1321369004313	active site 1 [active]
1321369004314	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1321369004315	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1321369004316	generic binding surface II; other site
1321369004317	ssDNA binding site; other site
1321369004318	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369004319	ATP binding site [chemical binding]; other site
1321369004320	putative Mg++ binding site [ion binding]; other site
1321369004321	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369004322	nucleotide binding region [chemical binding]; other site
1321369004323	ATP-binding site [chemical binding]; other site
1321369004324	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1321369004325	DAK2 domain; Region: Dak2; pfam02734
1321369004326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1321369004327	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1321369004328	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1321369004329	Thiamine pyrophosphokinase; Region: TPK; cd07995
1321369004330	active site
1321369004331	dimerization interface [polypeptide binding]; other site
1321369004332	thiamine binding site [chemical binding]; other site
1321369004333	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1321369004334	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1321369004335	substrate binding site [chemical binding]; other site
1321369004336	hexamer interface [polypeptide binding]; other site
1321369004337	metal binding site [ion binding]; metal-binding site
1321369004338	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1321369004339	RNA binding site [nucleotide binding]; other site
1321369004340	Predicted GTPases [General function prediction only]; Region: COG1162
1321369004341	homodimer interface [polypeptide binding]; other site
1321369004342	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1321369004343	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1321369004344	GTP/Mg2+ binding site [chemical binding]; other site
1321369004345	G4 box; other site
1321369004346	G5 box; other site
1321369004347	G1 box; other site
1321369004348	Switch I region; other site
1321369004349	G2 box; other site
1321369004350	G3 box; other site
1321369004351	Switch II region; other site
1321369004352	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1321369004353	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1321369004354	active site
1321369004355	ATP binding site [chemical binding]; other site
1321369004356	substrate binding site [chemical binding]; other site
1321369004357	activation loop (A-loop); other site
1321369004358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1321369004359	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1321369004360	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1321369004361	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1321369004362	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1321369004363	Protein phosphatase 2C; Region: PP2C; pfam00481
1321369004364	active site
1321369004365	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1321369004366	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369004367	FeS/SAM binding site; other site
1321369004368	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1321369004369	NusB family; Region: NusB; pfam01029
1321369004370	putative RNA binding site [nucleotide binding]; other site
1321369004371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369004372	S-adenosylmethionine binding site [chemical binding]; other site
1321369004373	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1321369004374	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1321369004375	putative active site [active]
1321369004376	substrate binding site [chemical binding]; other site
1321369004377	putative cosubstrate binding site; other site
1321369004378	catalytic site [active]
1321369004379	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1321369004380	substrate binding site [chemical binding]; other site
1321369004381	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1321369004382	active site
1321369004383	catalytic residues [active]
1321369004384	metal binding site [ion binding]; metal-binding site
1321369004385	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1321369004386	primosome assembly protein PriA; Validated; Region: PRK05580
1321369004387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369004388	ATP binding site [chemical binding]; other site
1321369004389	putative Mg++ binding site [ion binding]; other site
1321369004390	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1321369004391	nucleotide binding region [chemical binding]; other site
1321369004392	ATP-binding site [chemical binding]; other site
1321369004393	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1321369004394	Flavoprotein; Region: Flavoprotein; pfam02441
1321369004395	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1321369004396	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1321369004397	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1321369004398	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1321369004399	catalytic site [active]
1321369004400	G-X2-G-X-G-K; other site
1321369004401	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1321369004402	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1321369004403	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1321369004404	dimer interface [polypeptide binding]; other site
1321369004405	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369004406	active site
1321369004407	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1321369004408	active site
1321369004409	dimer interface [polypeptide binding]; other site
1321369004410	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1321369004411	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1321369004412	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1321369004413	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1321369004414	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1321369004415	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1321369004416	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1321369004417	IMP binding site; other site
1321369004418	dimer interface [polypeptide binding]; other site
1321369004419	interdomain contacts; other site
1321369004420	partial ornithine binding site; other site
1321369004421	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1321369004422	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1321369004423	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1321369004424	catalytic site [active]
1321369004425	subunit interface [polypeptide binding]; other site
1321369004426	dihydroorotase; Validated; Region: pyrC; PRK09357
1321369004427	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1321369004428	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1321369004429	active site
1321369004430	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1321369004431	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1321369004432	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1321369004433	uracil transporter; Provisional; Region: PRK10720
1321369004434	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1321369004435	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1321369004436	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1321369004437	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369004438	RNA binding surface [nucleotide binding]; other site
1321369004439	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1321369004440	active site
1321369004441	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1321369004442	lipoprotein signal peptidase; Provisional; Region: PRK14787
1321369004443	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1321369004444	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1321369004445	active site
1321369004446	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1321369004447	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1321369004448	HIGH motif; other site
1321369004449	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1321369004450	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1321369004451	active site
1321369004452	KMSKS motif; other site
1321369004453	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1321369004454	tRNA binding surface [nucleotide binding]; other site
1321369004455	anticodon binding site; other site
1321369004456	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1321369004457	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1321369004458	DivIVA domain; Region: DivI1A_domain; TIGR03544
1321369004459	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1321369004460	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369004461	RNA binding surface [nucleotide binding]; other site
1321369004462	YGGT family; Region: YGGT; pfam02325
1321369004463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1321369004464	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1321369004465	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1321369004466	cell division protein FtsZ; Validated; Region: PRK09330
1321369004467	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1321369004468	nucleotide binding site [chemical binding]; other site
1321369004469	SulA interaction site; other site
1321369004470	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1321369004471	Cell division protein FtsA; Region: FtsA; smart00842
1321369004472	Cell division protein FtsA; Region: FtsA; pfam14450
1321369004473	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1321369004474	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1321369004475	Cell division protein FtsQ; Region: FtsQ; pfam03799
1321369004476	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1321369004477	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1321369004478	NAD binding site [chemical binding]; other site
1321369004479	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1321369004480	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1321369004481	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1321369004482	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1321369004483	Mg++ binding site [ion binding]; other site
1321369004484	putative catalytic motif [active]
1321369004485	putative substrate binding site [chemical binding]; other site
1321369004486	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1321369004487	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1321369004488	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1321369004489	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1321369004490	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1321369004491	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1321369004492	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1321369004493	MraW methylase family; Region: Methyltransf_5; pfam01795
1321369004494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1321369004495	MraZ protein; Region: MraZ; pfam02381
1321369004496	MraZ protein; Region: MraZ; pfam02381
1321369004497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1321369004498	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1321369004499	hypothetical protein; Provisional; Region: PRK13688
1321369004500	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1321369004501	Coenzyme A binding pocket [chemical binding]; other site
1321369004502	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1321369004503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369004504	motif II; other site
1321369004505	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1321369004506	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1321369004507	gating phenylalanine in ion channel; other site
1321369004508	Predicted membrane protein [Function unknown]; Region: COG1288
1321369004509	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1321369004510	carbamate kinase; Reviewed; Region: PRK12686
1321369004511	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1321369004512	putative substrate binding site [chemical binding]; other site
1321369004513	nucleotide binding site [chemical binding]; other site
1321369004514	nucleotide binding site [chemical binding]; other site
1321369004515	homodimer interface [polypeptide binding]; other site
1321369004516	ornithine carbamoyltransferase; Provisional; Region: PRK04284
1321369004517	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1321369004518	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1321369004519	superantigen-like protein; Reviewed; Region: PRK13043
1321369004520	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369004521	superantigen-like protein; Reviewed; Region: PRK13349
1321369004522	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369004523	superantigen-like protein; Reviewed; Region: PRK13350
1321369004524	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369004525	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1321369004526	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1321369004527	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1321369004528	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
1321369004529	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1321369004530	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1321369004531	active site
1321369004532	metal binding site [ion binding]; metal-binding site
1321369004533	homotetramer interface [polypeptide binding]; other site
1321369004534	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1321369004535	active site
1321369004536	dimerization interface [polypeptide binding]; other site
1321369004537	glutamate racemase; Provisional; Region: PRK00865
1321369004538	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1321369004539	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1321369004540	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1321369004541	L-aspartate oxidase; Provisional; Region: PRK06175
1321369004542	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1321369004543	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1321369004544	putative Iron-sulfur protein interface [polypeptide binding]; other site
1321369004545	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1321369004546	proximal heme binding site [chemical binding]; other site
1321369004547	distal heme binding site [chemical binding]; other site
1321369004548	putative dimer interface [polypeptide binding]; other site
1321369004549	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1321369004550	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1321369004551	GIY-YIG motif/motif A; other site
1321369004552	active site
1321369004553	catalytic site [active]
1321369004554	putative DNA binding site [nucleotide binding]; other site
1321369004555	metal binding site [ion binding]; metal-binding site
1321369004556	UvrB/uvrC motif; Region: UVR; pfam02151
1321369004557	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1321369004558	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1321369004559	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1321369004560	catalytic residues [active]
1321369004561	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1321369004562	MutS domain III; Region: MutS_III; pfam05192
1321369004563	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1321369004564	Walker A/P-loop; other site
1321369004565	ATP binding site [chemical binding]; other site
1321369004566	Q-loop/lid; other site
1321369004567	ABC transporter signature motif; other site
1321369004568	Walker B; other site
1321369004569	D-loop; other site
1321369004570	H-loop/switch region; other site
1321369004571	Smr domain; Region: Smr; pfam01713
1321369004572	hypothetical protein; Provisional; Region: PRK08609
1321369004573	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1321369004574	active site
1321369004575	primer binding site [nucleotide binding]; other site
1321369004576	NTP  binding site [chemical binding]; other site
1321369004577	metal binding triad [ion binding]; metal-binding site
1321369004578	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1321369004579	active site
1321369004580	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1321369004581	Colicin V production protein; Region: Colicin_V; pfam02674
1321369004582	Cell division protein ZapA; Region: ZapA; cl01146
1321369004583	ribonuclease HIII; Provisional; Region: PRK00996
1321369004584	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1321369004585	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1321369004586	RNA/DNA hybrid binding site [nucleotide binding]; other site
1321369004587	active site
1321369004588	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1321369004589	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1321369004590	putative tRNA-binding site [nucleotide binding]; other site
1321369004591	B3/4 domain; Region: B3_4; pfam03483
1321369004592	tRNA synthetase B5 domain; Region: B5; smart00874
1321369004593	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1321369004594	dimer interface [polypeptide binding]; other site
1321369004595	motif 1; other site
1321369004596	motif 3; other site
1321369004597	motif 2; other site
1321369004598	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1321369004599	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1321369004600	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1321369004601	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1321369004602	dimer interface [polypeptide binding]; other site
1321369004603	motif 1; other site
1321369004604	active site
1321369004605	motif 2; other site
1321369004606	motif 3; other site
1321369004607	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1321369004608	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1321369004609	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1321369004610	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
1321369004611	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1321369004612	active site
1321369004613	catalytic site [active]
1321369004614	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1321369004615	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369004616	ABC-ATPase subunit  interface; other site
1321369004617	dimer interface [polypeptide binding]; other site
1321369004618	putative PBP binding regions; other site
1321369004619	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1321369004620	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1321369004621	intersubunit interface [polypeptide binding]; other site
1321369004622	heme uptake protein IsdC; Region: IsdC; TIGR03656
1321369004623	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1321369004624	heme-binding site [chemical binding]; other site
1321369004625	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
1321369004626	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
1321369004627	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1321369004628	heme-binding site [chemical binding]; other site
1321369004629	heme uptake protein IsdB; Region: IsdB; TIGR03657
1321369004630	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369004631	NEAr Transporter domain; Region: NEAT; smart00725
1321369004632	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1321369004633	heme-binding site [chemical binding]; other site
1321369004634	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1321369004635	CHAP domain; Region: CHAP; pfam05257
1321369004636	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1321369004637	amidase catalytic site [active]
1321369004638	Zn binding residues [ion binding]; other site
1321369004639	substrate binding site [chemical binding]; other site
1321369004640	Bacterial SH3 domain; Region: SH3_5; pfam08460
1321369004641	Bacteriophage holin; Region: Phage_holin_1; pfam04531
1321369004642	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
1321369004643	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
1321369004644	Phage tail repeat like; Region: PTR; pfam12789
1321369004645	CHAP domain; Region: CHAP; pfam05257
1321369004646	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1321369004647	Lysozyme subfamily 2; Region: LYZ2; smart00047
1321369004648	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
1321369004649	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
1321369004650	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
1321369004651	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
1321369004652	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1321369004653	active site
1321369004654	catalytic triad [active]
1321369004655	oxyanion hole [active]
1321369004656	Phage tail protein; Region: Sipho_tail; pfam05709
1321369004657	Phage-related protein [Function unknown]; Region: COG5412
1321369004658	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1321369004659	Phage protein; Region: DUF3647; pfam12363
1321369004660	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
1321369004661	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1321369004662	Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055
1321369004663	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1321369004664	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
1321369004665	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
1321369004666	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1321369004667	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
1321369004668	phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547
1321369004669	Terminase-like family; Region: Terminase_6; pfam03237
1321369004670	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
1321369004671	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1321369004672	trimer interface [polypeptide binding]; other site
1321369004673	active site
1321369004674	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
1321369004675	YopX protein; Region: YopX; pfam09643
1321369004676	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
1321369004677	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
1321369004678	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
1321369004679	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
1321369004680	active site
1321369004681	DNA binding site [nucleotide binding]
1321369004682	catalytic site [active]
1321369004683	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
1321369004684	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
1321369004685	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1321369004686	Homeodomain-like domain; Region: HTH_23; pfam13384
1321369004687	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1321369004688	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1321369004689	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369004690	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369004691	non-specific DNA binding site [nucleotide binding]; other site
1321369004692	salt bridge; other site
1321369004693	sequence-specific DNA binding site [nucleotide binding]; other site
1321369004694	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1321369004695	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1321369004696	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1321369004697	Int/Topo IB signature motif; other site
1321369004698	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1321369004699	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1321369004700	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1321369004701	dimerization interface [polypeptide binding]; other site
1321369004702	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1321369004703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369004704	dimer interface [polypeptide binding]; other site
1321369004705	phosphorylation site [posttranslational modification]
1321369004706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369004707	ATP binding site [chemical binding]; other site
1321369004708	Mg2+ binding site [ion binding]; other site
1321369004709	G-X-G motif; other site
1321369004710	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369004711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369004712	active site
1321369004713	phosphorylation site [posttranslational modification]
1321369004714	intermolecular recognition site; other site
1321369004715	dimerization interface [polypeptide binding]; other site
1321369004716	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369004717	DNA binding site [nucleotide binding]
1321369004718	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1321369004719	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369004720	RNA binding surface [nucleotide binding]; other site
1321369004721	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1321369004722	active site
1321369004723	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1321369004724	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1321369004725	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1321369004726	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1321369004727	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1321369004728	active site
1321369004729	Int/Topo IB signature motif; other site
1321369004730	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1321369004731	metal binding site 2 [ion binding]; metal-binding site
1321369004732	putative DNA binding helix; other site
1321369004733	metal binding site 1 [ion binding]; metal-binding site
1321369004734	dimer interface [polypeptide binding]; other site
1321369004735	structural Zn2+ binding site [ion binding]; other site
1321369004736	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1321369004737	dimer interface [polypeptide binding]; other site
1321369004738	ADP-ribose binding site [chemical binding]; other site
1321369004739	active site
1321369004740	nudix motif; other site
1321369004741	metal binding site [ion binding]; metal-binding site
1321369004742	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1321369004743	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1321369004744	active site
1321369004745	catalytic tetrad [active]
1321369004746	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1321369004747	classical (c) SDRs; Region: SDR_c; cd05233
1321369004748	NAD(P) binding site [chemical binding]; other site
1321369004749	active site
1321369004750	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1321369004751	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1321369004752	ribonuclease Z; Region: RNase_Z; TIGR02651
1321369004753	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1321369004754	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1321369004755	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1321369004756	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1321369004757	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1321369004758	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1321369004759	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1321369004760	Ca binding site [ion binding]; other site
1321369004761	active site
1321369004762	catalytic site [active]
1321369004763	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1321369004764	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1321369004765	DNA binding site [nucleotide binding]
1321369004766	domain linker motif; other site
1321369004767	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1321369004768	putative ligand binding site [chemical binding]; other site
1321369004769	putative dimerization interface [polypeptide binding]; other site
1321369004770	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1321369004771	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1321369004772	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1321369004773	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1321369004774	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1321369004775	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1321369004776	peptidase T-like protein; Region: PepT-like; TIGR01883
1321369004777	metal binding site [ion binding]; metal-binding site
1321369004778	putative dimer interface [polypeptide binding]; other site
1321369004779	Predicted membrane protein [Function unknown]; Region: COG4129
1321369004780	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1321369004781	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1321369004782	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1321369004783	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1321369004784	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1321369004785	E3 interaction surface; other site
1321369004786	lipoyl attachment site [posttranslational modification]; other site
1321369004787	e3 binding domain; Region: E3_binding; pfam02817
1321369004788	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1321369004789	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1321369004790	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1321369004791	alpha subunit interface [polypeptide binding]; other site
1321369004792	TPP binding site [chemical binding]; other site
1321369004793	heterodimer interface [polypeptide binding]; other site
1321369004794	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1321369004795	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1321369004796	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1321369004797	tetramer interface [polypeptide binding]; other site
1321369004798	TPP-binding site [chemical binding]; other site
1321369004799	heterodimer interface [polypeptide binding]; other site
1321369004800	phosphorylation loop region [posttranslational modification]
1321369004801	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1321369004802	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1321369004803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369004804	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1321369004805	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1321369004806	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1321369004807	Walker A/P-loop; other site
1321369004808	ATP binding site [chemical binding]; other site
1321369004809	Q-loop/lid; other site
1321369004810	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1321369004811	ABC transporter signature motif; other site
1321369004812	Walker B; other site
1321369004813	D-loop; other site
1321369004814	H-loop/switch region; other site
1321369004815	arginine repressor; Provisional; Region: PRK04280
1321369004816	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1321369004817	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1321369004818	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1321369004819	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1321369004820	substrate binding pocket [chemical binding]; other site
1321369004821	chain length determination region; other site
1321369004822	substrate-Mg2+ binding site; other site
1321369004823	catalytic residues [active]
1321369004824	aspartate-rich region 1; other site
1321369004825	active site lid residues [active]
1321369004826	aspartate-rich region 2; other site
1321369004827	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
1321369004828	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1321369004829	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1321369004830	generic binding surface II; other site
1321369004831	generic binding surface I; other site
1321369004832	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1321369004833	putative RNA binding site [nucleotide binding]; other site
1321369004834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1321369004835	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1321369004836	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1321369004837	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1321369004838	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1321369004839	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1321369004840	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1321369004841	carboxyltransferase (CT) interaction site; other site
1321369004842	biotinylation site [posttranslational modification]; other site
1321369004843	elongation factor P; Validated; Region: PRK00529
1321369004844	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1321369004845	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1321369004846	RNA binding site [nucleotide binding]; other site
1321369004847	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1321369004848	RNA binding site [nucleotide binding]; other site
1321369004849	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1321369004850	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1321369004851	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1321369004852	active site
1321369004853	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1321369004854	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1321369004855	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1321369004856	active site residue [active]
1321369004857	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1321369004858	tetramer interface [polypeptide binding]; other site
1321369004859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369004860	catalytic residue [active]
1321369004861	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1321369004862	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1321369004863	tetramer interface [polypeptide binding]; other site
1321369004864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369004865	catalytic residue [active]
1321369004866	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1321369004867	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1321369004868	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1321369004869	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1321369004870	ADP binding site [chemical binding]; other site
1321369004871	magnesium binding site [ion binding]; other site
1321369004872	putative shikimate binding site; other site
1321369004873	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1321369004874	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1321369004875	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1321369004876	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1321369004877	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1321369004878	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1321369004879	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1321369004880	Type II/IV secretion system protein; Region: T2SE; pfam00437
1321369004881	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1321369004882	Walker A motif; other site
1321369004883	ATP binding site [chemical binding]; other site
1321369004884	Walker B motif; other site
1321369004885	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1321369004886	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1321369004887	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1321369004888	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1321369004889	Rhomboid family; Region: Rhomboid; pfam01694
1321369004890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1321369004891	binding surface
1321369004892	TPR motif; other site
1321369004893	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1321369004894	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1321369004895	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1321369004896	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1321369004897	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1321369004898	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1321369004899	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1321369004900	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1321369004901	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1321369004902	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1321369004903	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1321369004904	metal binding site 2 [ion binding]; metal-binding site
1321369004905	putative DNA binding helix; other site
1321369004906	metal binding site 1 [ion binding]; metal-binding site
1321369004907	dimer interface [polypeptide binding]; other site
1321369004908	structural Zn2+ binding site [ion binding]; other site
1321369004909	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1321369004910	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369004911	ABC-ATPase subunit  interface; other site
1321369004912	dimer interface [polypeptide binding]; other site
1321369004913	putative PBP binding regions; other site
1321369004914	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1321369004915	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1321369004916	endonuclease IV; Provisional; Region: PRK01060
1321369004917	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1321369004918	AP (apurinic/apyrimidinic) site pocket; other site
1321369004919	DNA interaction; other site
1321369004920	Metal-binding active site; metal-binding site
1321369004921	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1321369004922	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1321369004923	ATP binding site [chemical binding]; other site
1321369004924	putative Mg++ binding site [ion binding]; other site
1321369004925	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369004926	nucleotide binding region [chemical binding]; other site
1321369004927	ATP-binding site [chemical binding]; other site
1321369004928	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1321369004929	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1321369004930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1321369004931	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1321369004932	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1321369004933	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1321369004934	Family of unknown function (DUF633); Region: DUF633; pfam04816
1321369004935	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1321369004936	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1321369004937	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1321369004938	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1321369004939	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1321369004940	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1321369004941	DNA binding residues [nucleotide binding]
1321369004942	DNA primase, catalytic core; Region: dnaG; TIGR01391
1321369004943	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1321369004944	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1321369004945	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1321369004946	active site
1321369004947	metal binding site [ion binding]; metal-binding site
1321369004948	interdomain interaction site; other site
1321369004949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
1321369004950	HTH domain; Region: HTH_11; cl17392
1321369004951	FOG: CBS domain [General function prediction only]; Region: COG0517
1321369004952	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1321369004953	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1321369004954	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1321369004955	motif 1; other site
1321369004956	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1321369004957	active site
1321369004958	motif 2; other site
1321369004959	motif 3; other site
1321369004960	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1321369004961	anticodon binding site; other site
1321369004962	DNA repair protein RecO; Region: reco; TIGR00613
1321369004963	Recombination protein O N terminal; Region: RecO_N; pfam11967
1321369004964	Recombination protein O C terminal; Region: RecO_C; pfam02565
1321369004965	GTPase Era; Reviewed; Region: era; PRK00089
1321369004966	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1321369004967	G1 box; other site
1321369004968	GTP/Mg2+ binding site [chemical binding]; other site
1321369004969	Switch I region; other site
1321369004970	G2 box; other site
1321369004971	Switch II region; other site
1321369004972	G3 box; other site
1321369004973	G4 box; other site
1321369004974	G5 box; other site
1321369004975	KH domain; Region: KH_2; pfam07650
1321369004976	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1321369004977	active site
1321369004978	catalytic motif [active]
1321369004979	Zn binding site [ion binding]; other site
1321369004980	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1321369004981	metal-binding heat shock protein; Provisional; Region: PRK00016
1321369004982	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1321369004983	PhoH-like protein; Region: PhoH; pfam02562
1321369004984	hypothetical protein; Provisional; Region: PRK13665
1321369004985	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1321369004986	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1321369004987	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1321369004988	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1321369004989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369004990	FeS/SAM binding site; other site
1321369004991	TRAM domain; Region: TRAM; cl01282
1321369004992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1321369004993	RNA methyltransferase, RsmE family; Region: TIGR00046
1321369004994	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1321369004995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369004996	S-adenosylmethionine binding site [chemical binding]; other site
1321369004997	chaperone protein DnaJ; Provisional; Region: PRK14280
1321369004998	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1321369004999	HSP70 interaction site [polypeptide binding]; other site
1321369005000	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1321369005001	substrate binding site [polypeptide binding]; other site
1321369005002	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1321369005003	Zn binding sites [ion binding]; other site
1321369005004	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1321369005005	dimer interface [polypeptide binding]; other site
1321369005006	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1321369005007	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1321369005008	nucleotide binding site [chemical binding]; other site
1321369005009	NEF interaction site [polypeptide binding]; other site
1321369005010	SBD interface [polypeptide binding]; other site
1321369005011	heat shock protein GrpE; Provisional; Region: PRK14140
1321369005012	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1321369005013	dimer interface [polypeptide binding]; other site
1321369005014	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1321369005015	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1321369005016	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
1321369005017	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
1321369005018	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1321369005019	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369005020	FeS/SAM binding site; other site
1321369005021	HemN C-terminal domain; Region: HemN_C; pfam06969
1321369005022	GTP-binding protein LepA; Provisional; Region: PRK05433
1321369005023	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1321369005024	G1 box; other site
1321369005025	putative GEF interaction site [polypeptide binding]; other site
1321369005026	GTP/Mg2+ binding site [chemical binding]; other site
1321369005027	Switch I region; other site
1321369005028	G2 box; other site
1321369005029	G3 box; other site
1321369005030	Switch II region; other site
1321369005031	G4 box; other site
1321369005032	G5 box; other site
1321369005033	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1321369005034	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1321369005035	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1321369005036	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1321369005037	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1321369005038	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1321369005039	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1321369005040	Competence protein; Region: Competence; pfam03772
1321369005041	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1321369005042	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1321369005043	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1321369005044	catalytic motif [active]
1321369005045	Zn binding site [ion binding]; other site
1321369005046	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1321369005047	SLBB domain; Region: SLBB; pfam10531
1321369005048	Helix-hairpin-helix motif; Region: HHH; pfam00633
1321369005049	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1321369005050	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1321369005051	Zn2+ binding site [ion binding]; other site
1321369005052	Mg2+ binding site [ion binding]; other site
1321369005053	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1321369005054	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1321369005055	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1321369005056	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1321369005057	shikimate binding site; other site
1321369005058	NAD(P) binding site [chemical binding]; other site
1321369005059	GTPase YqeH; Provisional; Region: PRK13796
1321369005060	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1321369005061	GTP/Mg2+ binding site [chemical binding]; other site
1321369005062	G4 box; other site
1321369005063	G5 box; other site
1321369005064	G1 box; other site
1321369005065	Switch I region; other site
1321369005066	G2 box; other site
1321369005067	G3 box; other site
1321369005068	Switch II region; other site
1321369005069	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1321369005070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369005071	active site
1321369005072	motif I; other site
1321369005073	motif II; other site
1321369005074	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1321369005075	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1321369005076	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1321369005077	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1321369005078	Fic family protein [Function unknown]; Region: COG3177
1321369005079	Fic/DOC family; Region: Fic; pfam02661
1321369005080	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1321369005081	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1321369005082	putative active site [active]
1321369005083	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1321369005084	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1321369005085	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1321369005086	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1321369005087	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1321369005088	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1321369005089	carboxyltransferase (CT) interaction site; other site
1321369005090	biotinylation site [posttranslational modification]; other site
1321369005091	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1321369005092	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1321369005093	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1321369005094	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1321369005095	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1321369005096	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1321369005097	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1321369005098	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1321369005099	Sugar specificity; other site
1321369005100	Pyrimidine base specificity; other site
1321369005101	ATP-binding site [chemical binding]; other site
1321369005102	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1321369005103	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1321369005104	Peptidase family U32; Region: Peptidase_U32; pfam01136
1321369005105	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1321369005106	Peptidase family U32; Region: Peptidase_U32; pfam01136
1321369005107	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1321369005108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005109	S-adenosylmethionine binding site [chemical binding]; other site
1321369005110	hypothetical protein; Provisional; Region: PRK13678
1321369005111	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
1321369005112	hypothetical protein; Provisional; Region: PRK05473
1321369005113	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1321369005114	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1321369005115	motif 1; other site
1321369005116	active site
1321369005117	motif 2; other site
1321369005118	motif 3; other site
1321369005119	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1321369005120	DHHA1 domain; Region: DHHA1; pfam02272
1321369005121	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1321369005122	AAA domain; Region: AAA_30; pfam13604
1321369005123	Family description; Region: UvrD_C_2; pfam13538
1321369005124	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1321369005125	binding surface
1321369005126	TPR motif; other site
1321369005127	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1321369005128	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1321369005129	binding surface
1321369005130	TPR motif; other site
1321369005131	TPR repeat; Region: TPR_11; pfam13414
1321369005132	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1321369005133	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1321369005134	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1321369005135	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1321369005136	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369005137	catalytic residue [active]
1321369005138	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1321369005139	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1321369005140	Predicted transcriptional regulator [Transcription]; Region: COG1959
1321369005141	Transcriptional regulator; Region: Rrf2; pfam02082
1321369005142	recombination factor protein RarA; Reviewed; Region: PRK13342
1321369005143	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369005144	Walker A motif; other site
1321369005145	ATP binding site [chemical binding]; other site
1321369005146	Walker B motif; other site
1321369005147	arginine finger; other site
1321369005148	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1321369005149	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1321369005150	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1321369005151	putative ATP binding site [chemical binding]; other site
1321369005152	putative substrate interface [chemical binding]; other site
1321369005153	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1321369005154	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1321369005155	dimer interface [polypeptide binding]; other site
1321369005156	anticodon binding site; other site
1321369005157	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1321369005158	homodimer interface [polypeptide binding]; other site
1321369005159	motif 1; other site
1321369005160	active site
1321369005161	motif 2; other site
1321369005162	GAD domain; Region: GAD; pfam02938
1321369005163	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1321369005164	motif 3; other site
1321369005165	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1321369005166	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1321369005167	dimer interface [polypeptide binding]; other site
1321369005168	motif 1; other site
1321369005169	active site
1321369005170	motif 2; other site
1321369005171	motif 3; other site
1321369005172	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1321369005173	anticodon binding site; other site
1321369005174	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1321369005175	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1321369005176	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1321369005177	active site
1321369005178	metal binding site [ion binding]; metal-binding site
1321369005179	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1321369005180	putative active site [active]
1321369005181	dimerization interface [polypeptide binding]; other site
1321369005182	putative tRNAtyr binding site [nucleotide binding]; other site
1321369005183	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1321369005184	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1321369005185	Zn2+ binding site [ion binding]; other site
1321369005186	Mg2+ binding site [ion binding]; other site
1321369005187	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1321369005188	synthetase active site [active]
1321369005189	NTP binding site [chemical binding]; other site
1321369005190	metal binding site [ion binding]; metal-binding site
1321369005191	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1321369005192	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1321369005193	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1321369005194	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369005195	active site
1321369005196	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1321369005197	DHH family; Region: DHH; pfam01368
1321369005198	DHHA1 domain; Region: DHHA1; pfam02272
1321369005199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1321369005200	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1321369005201	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1321369005202	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1321369005203	Protein export membrane protein; Region: SecD_SecF; pfam02355
1321369005204	Preprotein translocase subunit; Region: YajC; pfam02699
1321369005205	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1321369005206	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1321369005207	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1321369005208	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1321369005209	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1321369005210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369005211	Walker A motif; other site
1321369005212	ATP binding site [chemical binding]; other site
1321369005213	Walker B motif; other site
1321369005214	arginine finger; other site
1321369005215	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1321369005216	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1321369005217	RuvA N terminal domain; Region: RuvA_N; pfam01330
1321369005218	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1321369005219	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
1321369005220	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1321369005221	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1321369005222	GTP1/OBG; Region: GTP1_OBG; pfam01018
1321369005223	Obg GTPase; Region: Obg; cd01898
1321369005224	G1 box; other site
1321369005225	GTP/Mg2+ binding site [chemical binding]; other site
1321369005226	Switch I region; other site
1321369005227	G2 box; other site
1321369005228	G3 box; other site
1321369005229	Switch II region; other site
1321369005230	G4 box; other site
1321369005231	G5 box; other site
1321369005232	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1321369005233	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1321369005234	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
1321369005235	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1321369005236	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1321369005237	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1321369005238	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1321369005239	rod shape-determining protein MreC; Region: MreC; pfam04085
1321369005240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005241	S-adenosylmethionine binding site [chemical binding]; other site
1321369005242	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1321369005243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005244	S-adenosylmethionine binding site [chemical binding]; other site
1321369005245	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1321369005246	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1321369005247	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1321369005248	Int/Topo IB signature motif; other site
1321369005249	hypothetical protein; Reviewed; Region: PRK00024
1321369005250	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1321369005251	MPN+ (JAMM) motif; other site
1321369005252	Zinc-binding site [ion binding]; other site
1321369005253	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1321369005254	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1321369005255	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1321369005256	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1321369005257	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1321369005258	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1321369005259	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1321369005260	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1321369005261	active site
1321369005262	HIGH motif; other site
1321369005263	nucleotide binding site [chemical binding]; other site
1321369005264	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1321369005265	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1321369005266	active site
1321369005267	KMSKS motif; other site
1321369005268	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1321369005269	tRNA binding surface [nucleotide binding]; other site
1321369005270	anticodon binding site; other site
1321369005271	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1321369005272	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1321369005273	Putative ammonia monooxygenase; Region: AmoA; pfam05145
1321369005274	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1321369005275	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1321369005276	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1321369005277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1321369005278	inhibitor-cofactor binding pocket; inhibition site
1321369005279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369005280	catalytic residue [active]
1321369005281	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1321369005282	dimer interface [polypeptide binding]; other site
1321369005283	active site
1321369005284	Schiff base residues; other site
1321369005285	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1321369005286	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1321369005287	active site
1321369005288	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1321369005289	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1321369005290	domain interfaces; other site
1321369005291	active site
1321369005292	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
1321369005293	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1321369005294	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1321369005295	tRNA; other site
1321369005296	putative tRNA binding site [nucleotide binding]; other site
1321369005297	putative NADP binding site [chemical binding]; other site
1321369005298	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1321369005299	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1321369005300	G1 box; other site
1321369005301	GTP/Mg2+ binding site [chemical binding]; other site
1321369005302	Switch I region; other site
1321369005303	G2 box; other site
1321369005304	G3 box; other site
1321369005305	Switch II region; other site
1321369005306	G4 box; other site
1321369005307	G5 box; other site
1321369005308	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1321369005309	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1321369005310	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369005311	Walker A motif; other site
1321369005312	ATP binding site [chemical binding]; other site
1321369005313	Walker B motif; other site
1321369005314	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1321369005315	trigger factor; Provisional; Region: tig; PRK01490
1321369005316	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1321369005317	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1321369005318	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1321369005319	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1321369005320	23S rRNA binding site [nucleotide binding]; other site
1321369005321	L21 binding site [polypeptide binding]; other site
1321369005322	L13 binding site [polypeptide binding]; other site
1321369005323	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1321369005324	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1321369005325	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1321369005326	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1321369005327	lysine transporter; Provisional; Region: PRK10836
1321369005328	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1321369005329	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1321369005330	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1321369005331	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1321369005332	active site
1321369005333	dimer interface [polypeptide binding]; other site
1321369005334	motif 1; other site
1321369005335	motif 2; other site
1321369005336	motif 3; other site
1321369005337	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1321369005338	anticodon binding site; other site
1321369005339	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1321369005340	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1321369005341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369005342	Walker A motif; other site
1321369005343	ATP binding site [chemical binding]; other site
1321369005344	Walker B motif; other site
1321369005345	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1321369005346	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1321369005347	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1321369005348	ATP cone domain; Region: ATP-cone; pfam03477
1321369005349	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1321369005350	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1321369005351	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1321369005352	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1321369005353	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1321369005354	CoA-binding site [chemical binding]; other site
1321369005355	ATP-binding [chemical binding]; other site
1321369005356	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1321369005357	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1321369005358	DNA binding site [nucleotide binding]
1321369005359	catalytic residue [active]
1321369005360	H2TH interface [polypeptide binding]; other site
1321369005361	putative catalytic residues [active]
1321369005362	turnover-facilitating residue; other site
1321369005363	intercalation triad [nucleotide binding]; other site
1321369005364	8OG recognition residue [nucleotide binding]; other site
1321369005365	putative reading head residues; other site
1321369005366	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1321369005367	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1321369005368	DNA polymerase I; Provisional; Region: PRK05755
1321369005369	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1321369005370	active site
1321369005371	metal binding site 1 [ion binding]; metal-binding site
1321369005372	putative 5' ssDNA interaction site; other site
1321369005373	metal binding site 3; metal-binding site
1321369005374	metal binding site 2 [ion binding]; metal-binding site
1321369005375	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1321369005376	putative DNA binding site [nucleotide binding]; other site
1321369005377	putative metal binding site [ion binding]; other site
1321369005378	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1321369005379	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1321369005380	active site
1321369005381	DNA binding site [nucleotide binding]
1321369005382	catalytic site [active]
1321369005383	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1321369005384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369005385	dimer interface [polypeptide binding]; other site
1321369005386	phosphorylation site [posttranslational modification]
1321369005387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369005388	ATP binding site [chemical binding]; other site
1321369005389	Mg2+ binding site [ion binding]; other site
1321369005390	G-X-G motif; other site
1321369005391	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369005392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369005393	active site
1321369005394	phosphorylation site [posttranslational modification]
1321369005395	intermolecular recognition site; other site
1321369005396	dimerization interface [polypeptide binding]; other site
1321369005397	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369005398	DNA binding site [nucleotide binding]
1321369005399	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1321369005400	isocitrate dehydrogenase; Validated; Region: PRK07362
1321369005401	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1321369005402	dimer interface [polypeptide binding]; other site
1321369005403	Citrate synthase; Region: Citrate_synt; pfam00285
1321369005404	active site
1321369005405	citrylCoA binding site [chemical binding]; other site
1321369005406	oxalacetate/citrate binding site [chemical binding]; other site
1321369005407	coenzyme A binding site [chemical binding]; other site
1321369005408	catalytic triad [active]
1321369005409	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1321369005410	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369005411	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369005412	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369005413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369005414	pyruvate kinase; Provisional; Region: PRK06354
1321369005415	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1321369005416	domain interfaces; other site
1321369005417	active site
1321369005418	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1321369005419	6-phosphofructokinase; Provisional; Region: PRK03202
1321369005420	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1321369005421	active site
1321369005422	ADP/pyrophosphate binding site [chemical binding]; other site
1321369005423	dimerization interface [polypeptide binding]; other site
1321369005424	allosteric effector site; other site
1321369005425	fructose-1,6-bisphosphate binding site; other site
1321369005426	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1321369005427	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1321369005428	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1321369005429	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1321369005430	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1321369005431	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1321369005432	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1321369005433	putative NAD(P) binding site [chemical binding]; other site
1321369005434	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1321369005435	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1321369005436	active site
1321369005437	PHP Thumb interface [polypeptide binding]; other site
1321369005438	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1321369005439	generic binding surface I; other site
1321369005440	generic binding surface II; other site
1321369005441	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1321369005442	DHH family; Region: DHH; pfam01368
1321369005443	DHHA1 domain; Region: DHHA1; pfam02272
1321369005444	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1321369005445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1321369005446	DNA-binding site [nucleotide binding]; DNA binding site
1321369005447	DRTGG domain; Region: DRTGG; pfam07085
1321369005448	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1321369005449	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1321369005450	active site 2 [active]
1321369005451	active site 1 [active]
1321369005452	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1321369005453	Ligand Binding Site [chemical binding]; other site
1321369005454	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1321369005455	metal-dependent hydrolase; Provisional; Region: PRK00685
1321369005456	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1321369005457	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1321369005458	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1321369005459	active site
1321369005460	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1321369005461	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1321369005462	hexamer interface [polypeptide binding]; other site
1321369005463	ligand binding site [chemical binding]; other site
1321369005464	putative active site [active]
1321369005465	NAD(P) binding site [chemical binding]; other site
1321369005466	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1321369005467	Ligand Binding Site [chemical binding]; other site
1321369005468	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1321369005469	propionate/acetate kinase; Provisional; Region: PRK12379
1321369005470	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1321369005471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005472	S-adenosylmethionine binding site [chemical binding]; other site
1321369005473	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1321369005474	dimer interface [polypeptide binding]; other site
1321369005475	catalytic triad [active]
1321369005476	peroxidatic and resolving cysteines [active]
1321369005477	hypothetical protein; Provisional; Region: PRK10621
1321369005478	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1321369005479	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1321369005480	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1321369005481	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1321369005482	Ligand Binding Site [chemical binding]; other site
1321369005483	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1321369005484	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1321369005485	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369005486	catalytic residue [active]
1321369005487	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1321369005488	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1321369005489	GAF domain; Region: GAF_2; pfam13185
1321369005490	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1321369005491	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1321369005492	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369005493	RNA binding surface [nucleotide binding]; other site
1321369005494	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1321369005495	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1321369005496	active site
1321369005497	catalytic site [active]
1321369005498	OsmC-like protein; Region: OsmC; cl00767
1321369005499	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1321369005500	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369005501	catalytic residue [active]
1321369005502	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1321369005503	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1321369005504	ligand binding site [chemical binding]; other site
1321369005505	NAD binding site [chemical binding]; other site
1321369005506	dimerization interface [polypeptide binding]; other site
1321369005507	catalytic site [active]
1321369005508	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1321369005509	putative L-serine binding site [chemical binding]; other site
1321369005510	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1321369005511	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369005512	motif II; other site
1321369005513	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1321369005514	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369005515	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369005516	active site turn [active]
1321369005517	phosphorylation site [posttranslational modification]
1321369005518	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1321369005519	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1321369005520	putative acyl-acceptor binding pocket; other site
1321369005521	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1321369005522	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1321369005523	protein binding site [polypeptide binding]; other site
1321369005524	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1321369005525	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1321369005526	active site
1321369005527	HIGH motif; other site
1321369005528	dimer interface [polypeptide binding]; other site
1321369005529	KMSKS motif; other site
1321369005530	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369005531	RNA binding surface [nucleotide binding]; other site
1321369005532	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1321369005533	Transglycosylase; Region: Transgly; pfam00912
1321369005534	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
1321369005535	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1321369005536	NEAr Transporter domain; Region: NEAT; smart00725
1321369005537	NEAr Transporter domain; Region: NEAT; smart00725
1321369005538	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1321369005539	heme-binding site [chemical binding]; other site
1321369005540	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1321369005541	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1321369005542	Potassium binding sites [ion binding]; other site
1321369005543	Cesium cation binding sites [ion binding]; other site
1321369005544	acetyl-CoA synthetase; Provisional; Region: PRK04319
1321369005545	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1321369005546	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1321369005547	active site
1321369005548	acyl-activating enzyme (AAE) consensus motif; other site
1321369005549	putative CoA binding site [chemical binding]; other site
1321369005550	AMP binding site [chemical binding]; other site
1321369005551	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1321369005552	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1321369005553	active site
1321369005554	Zn binding site [ion binding]; other site
1321369005555	catabolite control protein A; Region: ccpA; TIGR01481
1321369005556	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1321369005557	DNA binding site [nucleotide binding]
1321369005558	domain linker motif; other site
1321369005559	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1321369005560	dimerization interface [polypeptide binding]; other site
1321369005561	effector binding site; other site
1321369005562	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1321369005563	Chorismate mutase type II; Region: CM_2; cl00693
1321369005564	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1321369005565	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1321369005566	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1321369005567	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1321369005568	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1321369005569	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1321369005570	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1321369005571	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1321369005572	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1321369005573	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1321369005574	putative tRNA-binding site [nucleotide binding]; other site
1321369005575	hypothetical protein; Provisional; Region: PRK13668
1321369005576	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1321369005577	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1321369005578	catalytic residues [active]
1321369005579	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1321369005580	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1321369005581	oligomer interface [polypeptide binding]; other site
1321369005582	active site
1321369005583	metal binding site [ion binding]; metal-binding site
1321369005584	Predicted small secreted protein [Function unknown]; Region: COG5584
1321369005585	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1321369005586	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005587	S-adenosylmethionine binding site [chemical binding]; other site
1321369005588	Phosphotransferase enzyme family; Region: APH; pfam01636
1321369005589	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1321369005590	active site
1321369005591	substrate binding site [chemical binding]; other site
1321369005592	ATP binding site [chemical binding]; other site
1321369005593	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1321369005594	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1321369005595	homodimer interface [polypeptide binding]; other site
1321369005596	substrate-cofactor binding pocket; other site
1321369005597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369005598	catalytic residue [active]
1321369005599	dipeptidase PepV; Reviewed; Region: PRK07318
1321369005600	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1321369005601	active site
1321369005602	metal binding site [ion binding]; metal-binding site
1321369005603	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1321369005604	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1321369005605	RNA binding surface [nucleotide binding]; other site
1321369005606	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1321369005607	active site
1321369005608	uracil binding [chemical binding]; other site
1321369005609	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1321369005610	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1321369005611	HI0933-like protein; Region: HI0933_like; pfam03486
1321369005612	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369005613	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1321369005614	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005615	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005616	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005617	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005618	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005619	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005620	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005621	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005622	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005623	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005624	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005625	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005626	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005627	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005628	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369005629	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1321369005630	active site residue [active]
1321369005631	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1321369005632	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1321369005633	HIGH motif; other site
1321369005634	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1321369005635	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1321369005636	active site
1321369005637	KMSKS motif; other site
1321369005638	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1321369005639	tRNA binding surface [nucleotide binding]; other site
1321369005640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369005641	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369005642	putative substrate translocation pore; other site
1321369005643	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1321369005644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005645	S-adenosylmethionine binding site [chemical binding]; other site
1321369005646	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369005647	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1321369005648	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1321369005649	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1321369005650	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1321369005651	homopentamer interface [polypeptide binding]; other site
1321369005652	active site
1321369005653	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1321369005654	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1321369005655	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1321369005656	dimerization interface [polypeptide binding]; other site
1321369005657	active site
1321369005658	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1321369005659	Lumazine binding domain; Region: Lum_binding; pfam00677
1321369005660	Lumazine binding domain; Region: Lum_binding; pfam00677
1321369005661	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1321369005662	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1321369005663	catalytic motif [active]
1321369005664	Zn binding site [ion binding]; other site
1321369005665	RibD C-terminal domain; Region: RibD_C; cl17279
1321369005666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1321369005667	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1321369005668	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1321369005669	arsenical pump membrane protein; Provisional; Region: PRK15445
1321369005670	transmembrane helices; other site
1321369005671	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1321369005672	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1321369005673	active site
1321369005674	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1321369005675	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1321369005676	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1321369005677	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1321369005678	DNA binding residues [nucleotide binding]
1321369005679	CAAX protease self-immunity; Region: Abi; pfam02517
1321369005680	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1321369005681	active site
1321369005682	intersubunit interactions; other site
1321369005683	catalytic residue [active]
1321369005684	camphor resistance protein CrcB; Provisional; Region: PRK14201
1321369005685	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1321369005686	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1321369005687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369005688	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369005689	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369005690	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1321369005691	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1321369005692	active site
1321369005693	catalytic tetrad [active]
1321369005694	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1321369005695	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1321369005696	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1321369005697	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1321369005698	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1321369005699	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1321369005700	active site
1321369005701	substrate-binding site [chemical binding]; other site
1321369005702	metal-binding site [ion binding]
1321369005703	ATP binding site [chemical binding]; other site
1321369005704	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1321369005705	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1321369005706	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1321369005707	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1321369005708	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1321369005709	nudix motif; other site
1321369005710	Haemolytic domain; Region: Haemolytic; pfam01809
1321369005711	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1321369005712	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1321369005713	metal binding site [ion binding]; metal-binding site
1321369005714	substrate binding pocket [chemical binding]; other site
1321369005715	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1321369005716	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1321369005717	acyl-activating enzyme (AAE) consensus motif; other site
1321369005718	putative AMP binding site [chemical binding]; other site
1321369005719	putative active site [active]
1321369005720	putative CoA binding site [chemical binding]; other site
1321369005721	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1321369005722	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1321369005723	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
1321369005724	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1321369005725	putative transposase OrfB; Reviewed; Region: PHA02517
1321369005726	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1321369005727	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1321369005728	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1321369005729	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1321369005730	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1321369005731	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1321369005732	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1321369005733	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1321369005734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005735	S-adenosylmethionine binding site [chemical binding]; other site
1321369005736	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369005737	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1321369005738	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369005739	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1321369005740	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369005741	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1321369005742	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369005743	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369005744	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1321369005745	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1321369005746	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
1321369005747	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1321369005748	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1321369005749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369005750	Walker A/P-loop; other site
1321369005751	ATP binding site [chemical binding]; other site
1321369005752	Q-loop/lid; other site
1321369005753	ABC transporter signature motif; other site
1321369005754	Walker B; other site
1321369005755	D-loop; other site
1321369005756	H-loop/switch region; other site
1321369005757	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
1321369005758	active site
1321369005759	catalytic triad [active]
1321369005760	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
1321369005761	Flavoprotein; Region: Flavoprotein; pfam02441
1321369005762	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
1321369005763	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
1321369005764	active site
1321369005765	zinc binding site [ion binding]; other site
1321369005766	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
1321369005767	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
1321369005768	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
1321369005769	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
1321369005770	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
1321369005771	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1321369005772	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1321369005773	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1321369005774	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1321369005775	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1321369005776	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1321369005777	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1321369005778	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1321369005779	ferrochelatase; Provisional; Region: PRK12435
1321369005780	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1321369005781	C-terminal domain interface [polypeptide binding]; other site
1321369005782	active site
1321369005783	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1321369005784	active site
1321369005785	N-terminal domain interface [polypeptide binding]; other site
1321369005786	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1321369005787	substrate binding site [chemical binding]; other site
1321369005788	active site
1321369005789	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1321369005790	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1321369005791	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1321369005792	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1321369005793	Walker A/P-loop; other site
1321369005794	ATP binding site [chemical binding]; other site
1321369005795	Q-loop/lid; other site
1321369005796	ABC transporter signature motif; other site
1321369005797	Walker B; other site
1321369005798	D-loop; other site
1321369005799	H-loop/switch region; other site
1321369005800	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1321369005801	HIT family signature motif; other site
1321369005802	catalytic residue [active]
1321369005803	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1321369005804	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1321369005805	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1321369005806	SurA N-terminal domain; Region: SurA_N_3; cl07813
1321369005807	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1321369005808	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1321369005809	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1321369005810	generic binding surface II; other site
1321369005811	generic binding surface I; other site
1321369005812	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1321369005813	Zn2+ binding site [ion binding]; other site
1321369005814	Mg2+ binding site [ion binding]; other site
1321369005815	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1321369005816	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1321369005817	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
1321369005818	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1321369005819	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1321369005820	active site
1321369005821	metal binding site [ion binding]; metal-binding site
1321369005822	DNA binding site [nucleotide binding]
1321369005823	hypothetical protein; Provisional; Region: PRK13676
1321369005824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1321369005825	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369005826	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369005827	non-specific DNA binding site [nucleotide binding]; other site
1321369005828	salt bridge; other site
1321369005829	sequence-specific DNA binding site [nucleotide binding]; other site
1321369005830	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1321369005831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369005832	active site
1321369005833	phosphorylation site [posttranslational modification]
1321369005834	intermolecular recognition site; other site
1321369005835	dimerization interface [polypeptide binding]; other site
1321369005836	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1321369005837	DNA binding residues [nucleotide binding]
1321369005838	dimerization interface [polypeptide binding]; other site
1321369005839	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1321369005840	GAF domain; Region: GAF_3; pfam13492
1321369005841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1321369005842	Histidine kinase; Region: HisKA_3; pfam07730
1321369005843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369005844	ATP binding site [chemical binding]; other site
1321369005845	Mg2+ binding site [ion binding]; other site
1321369005846	G-X-G motif; other site
1321369005847	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1321369005848	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1321369005849	active site
1321369005850	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1321369005851	Class II fumarases; Region: Fumarase_classII; cd01362
1321369005852	active site
1321369005853	tetramer interface [polypeptide binding]; other site
1321369005854	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1321369005855	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1321369005856	active site
1321369005857	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1321369005858	epoxyqueuosine reductase; Region: TIGR00276
1321369005859	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1321369005860	HEAT repeats; Region: HEAT_2; pfam13646
1321369005861	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1321369005862	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1321369005863	Walker A/P-loop; other site
1321369005864	ATP binding site [chemical binding]; other site
1321369005865	Q-loop/lid; other site
1321369005866	ABC transporter signature motif; other site
1321369005867	Walker B; other site
1321369005868	D-loop; other site
1321369005869	H-loop/switch region; other site
1321369005870	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1321369005871	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1321369005872	substrate binding pocket [chemical binding]; other site
1321369005873	membrane-bound complex binding site; other site
1321369005874	hinge residues; other site
1321369005875	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1321369005876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369005877	dimer interface [polypeptide binding]; other site
1321369005878	conserved gate region; other site
1321369005879	putative PBP binding loops; other site
1321369005880	ABC-ATPase subunit interface; other site
1321369005881	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1321369005882	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1321369005883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1321369005884	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1321369005885	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1321369005886	metal binding site 2 [ion binding]; metal-binding site
1321369005887	putative DNA binding helix; other site
1321369005888	metal binding site 1 [ion binding]; metal-binding site
1321369005889	dimer interface [polypeptide binding]; other site
1321369005890	structural Zn2+ binding site [ion binding]; other site
1321369005891	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1321369005892	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1321369005893	putative ligand binding site [chemical binding]; other site
1321369005894	NAD binding site [chemical binding]; other site
1321369005895	catalytic site [active]
1321369005896	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1321369005897	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1321369005898	catalytic triad [active]
1321369005899	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1321369005900	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1321369005901	inhibitor-cofactor binding pocket; inhibition site
1321369005902	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369005903	catalytic residue [active]
1321369005904	Predicted membrane protein [Function unknown]; Region: COG4129
1321369005905	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1321369005906	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1321369005907	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1321369005908	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1321369005909	Walker A/P-loop; other site
1321369005910	ATP binding site [chemical binding]; other site
1321369005911	Q-loop/lid; other site
1321369005912	ABC transporter signature motif; other site
1321369005913	Walker B; other site
1321369005914	D-loop; other site
1321369005915	H-loop/switch region; other site
1321369005916	hypothetical protein; Provisional; Region: PRK13662
1321369005917	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1321369005918	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1321369005919	minor groove reading motif; other site
1321369005920	helix-hairpin-helix signature motif; other site
1321369005921	substrate binding pocket [chemical binding]; other site
1321369005922	active site
1321369005923	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1321369005924	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1321369005925	DNA binding and oxoG recognition site [nucleotide binding]
1321369005926	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1321369005927	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1321369005928	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369005929	Walker A/P-loop; other site
1321369005930	ATP binding site [chemical binding]; other site
1321369005931	Q-loop/lid; other site
1321369005932	ABC transporter signature motif; other site
1321369005933	Walker B; other site
1321369005934	H-loop/switch region; other site
1321369005935	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1321369005936	recombination regulator RecX; Provisional; Region: recX; PRK14135
1321369005937	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1321369005938	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1321369005939	proposed catalytic triad [active]
1321369005940	conserved cys residue [active]
1321369005941	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1321369005942	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369005943	FeS/SAM binding site; other site
1321369005944	YfkB-like domain; Region: YfkB; pfam08756
1321369005945	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1321369005946	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1321369005947	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1321369005948	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
1321369005949	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1321369005950	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1321369005951	active site
1321369005952	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1321369005953	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1321369005954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369005955	active site
1321369005956	phosphorylation site [posttranslational modification]
1321369005957	intermolecular recognition site; other site
1321369005958	dimerization interface [polypeptide binding]; other site
1321369005959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1321369005960	DNA binding residues [nucleotide binding]
1321369005961	dimerization interface [polypeptide binding]; other site
1321369005962	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1321369005963	Histidine kinase; Region: HisKA_3; pfam07730
1321369005964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369005965	ATP binding site [chemical binding]; other site
1321369005966	Mg2+ binding site [ion binding]; other site
1321369005967	G-X-G motif; other site
1321369005968	Predicted membrane protein [Function unknown]; Region: COG4758
1321369005969	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1321369005970	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1321369005971	active site
1321369005972	Predicted membrane protein [Function unknown]; Region: COG4129
1321369005973	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1321369005974	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1321369005975	catalytic triad [active]
1321369005976	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1321369005977	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1321369005978	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1321369005979	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1321369005980	Ferritin-like domain; Region: Ferritin; pfam00210
1321369005981	ferroxidase diiron center [ion binding]; other site
1321369005982	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1321369005983	active site
1321369005984	catalytic site [active]
1321369005985	substrate binding site [chemical binding]; other site
1321369005986	DNA polymerase IV; Validated; Region: PRK02406
1321369005987	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1321369005988	active site
1321369005989	DNA binding site [nucleotide binding]
1321369005990	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1321369005991	TRAM domain; Region: TRAM; cl01282
1321369005992	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1321369005993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369005994	S-adenosylmethionine binding site [chemical binding]; other site
1321369005995	putative lipid kinase; Reviewed; Region: PRK13337
1321369005996	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1321369005997	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1321369005998	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1321369005999	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1321369006000	GatB domain; Region: GatB_Yqey; pfam02637
1321369006001	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1321369006002	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1321369006003	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1321369006004	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1321369006005	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1321369006006	Na binding site [ion binding]; other site
1321369006007	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1321369006008	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1321369006009	putative dimer interface [polypeptide binding]; other site
1321369006010	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1321369006011	putative dimer interface [polypeptide binding]; other site
1321369006012	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1321369006013	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1321369006014	nucleotide binding pocket [chemical binding]; other site
1321369006015	K-X-D-G motif; other site
1321369006016	catalytic site [active]
1321369006017	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1321369006018	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1321369006019	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1321369006020	Dimer interface [polypeptide binding]; other site
1321369006021	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1321369006022	Part of AAA domain; Region: AAA_19; pfam13245
1321369006023	Family description; Region: UvrD_C_2; pfam13538
1321369006024	PcrB family; Region: PcrB; pfam01884
1321369006025	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1321369006026	substrate binding site [chemical binding]; other site
1321369006027	putative active site [active]
1321369006028	dimer interface [polypeptide binding]; other site
1321369006029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
1321369006030	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1321369006031	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1321369006032	tetramer interface [polypeptide binding]; other site
1321369006033	active site
1321369006034	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1321369006035	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1321369006036	Staphostatin A; Region: Staphostatin_A; pfam09022
1321369006037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1321369006038	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1321369006039	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1321369006040	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1321369006041	homodimer interface [polypeptide binding]; other site
1321369006042	NAD binding pocket [chemical binding]; other site
1321369006043	ATP binding pocket [chemical binding]; other site
1321369006044	Mg binding site [ion binding]; other site
1321369006045	active-site loop [active]
1321369006046	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1321369006047	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1321369006048	active site
1321369006049	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1321369006050	active site
1321369006051	dimer interface [polypeptide binding]; other site
1321369006052	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1321369006053	Prephenate dehydratase; Region: PDT; pfam00800
1321369006054	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1321369006055	putative L-Phe binding site [chemical binding]; other site
1321369006056	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1321369006057	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1321369006058	transmembrane helices; other site
1321369006059	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1321369006060	Isochorismatase family; Region: Isochorismatase; pfam00857
1321369006061	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1321369006062	catalytic triad [active]
1321369006063	conserved cis-peptide bond; other site
1321369006064	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1321369006065	DHH family; Region: DHH; pfam01368
1321369006066	DHHA2 domain; Region: DHHA2; pfam02833
1321369006067	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1321369006068	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1321369006069	NAD(P) binding site [chemical binding]; other site
1321369006070	catalytic residues [active]
1321369006071	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1321369006072	YolD-like protein; Region: YolD; pfam08863
1321369006073	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1321369006074	active site
1321369006075	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1321369006076	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1321369006077	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1321369006078	Bacterial PH domain; Region: DUF304; cl01348
1321369006079	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
1321369006080	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1321369006081	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1321369006082	Walker A/P-loop; other site
1321369006083	ATP binding site [chemical binding]; other site
1321369006084	Q-loop/lid; other site
1321369006085	ABC transporter signature motif; other site
1321369006086	Walker B; other site
1321369006087	D-loop; other site
1321369006088	H-loop/switch region; other site
1321369006089	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1321369006090	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1321369006091	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1321369006092	Walker A/P-loop; other site
1321369006093	ATP binding site [chemical binding]; other site
1321369006094	Q-loop/lid; other site
1321369006095	ABC transporter signature motif; other site
1321369006096	Walker B; other site
1321369006097	D-loop; other site
1321369006098	H-loop/switch region; other site
1321369006099	Predicted transcriptional regulators [Transcription]; Region: COG1725
1321369006100	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1321369006101	DNA-binding site [nucleotide binding]; DNA binding site
1321369006102	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1321369006103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1321369006104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369006105	homodimer interface [polypeptide binding]; other site
1321369006106	catalytic residue [active]
1321369006107	MAP domain; Region: MAP; pfam03642
1321369006108	MAP domain; Region: MAP; pfam03642
1321369006109	MAP domain; Region: MAP; pfam03642
1321369006110	MAP domain; Region: MAP; pfam03642
1321369006111	MAP domain; Region: MAP; pfam03642
1321369006112	MAP domain; Region: MAP; pfam03642
1321369006113	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1321369006114	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1321369006115	chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032
1321369006116	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1321369006117	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1321369006118	CHAP domain; Region: CHAP; pfam05257
1321369006119	Small integral membrane protein [Function unknown]; Region: COG5546
1321369006120	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
1321369006121	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
1321369006122	TolA protein; Region: tolA_full; TIGR02794
1321369006123	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1321369006124	Phage tail protein; Region: Sipho_tail; cl17486
1321369006125	Phage tail protein; Region: Sipho_tail; cl17486
1321369006126	Phage-related minor tail protein [Function unknown]; Region: COG5280
1321369006127	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1321369006128	Phage-related protein [Function unknown]; Region: COG5412
1321369006129	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
1321369006130	Peptidase family M23; Region: Peptidase_M23; pfam01551
1321369006131	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1321369006132	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1321369006133	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1321369006134	catalytic residue [active]
1321369006135	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1321369006136	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
1321369006137	Translocation protein Sec62; Region: Sec62; cl02170
1321369006138	Phage capsid family; Region: Phage_capsid; pfam05065
1321369006139	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1321369006140	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1321369006141	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1321369006142	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1321369006143	HNH endonuclease; Region: HNH; pfam01844
1321369006144	active site
1321369006145	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1321369006146	dUTPase; Region: dUTPase_2; pfam08761
1321369006147	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1321369006148	active site
1321369006149	homodimer interface [polypeptide binding]; other site
1321369006150	metal binding site [ion binding]; metal-binding site
1321369006151	YopX protein; Region: YopX; pfam09643
1321369006152	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
1321369006153	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
1321369006154	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
1321369006155	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
1321369006156	Protein of unknown function (DUF3269); Region: DUF3269; pfam11673
1321369006157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369006158	Walker A motif; other site
1321369006159	ATP binding site [chemical binding]; other site
1321369006160	Walker B motif; other site
1321369006161	Helix-turn-helix domain; Region: HTH_36; pfam13730
1321369006162	phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220
1321369006163	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1321369006164	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1321369006165	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1321369006166	ssDNA binding site [nucleotide binding]; other site
1321369006167	dimer interface [polypeptide binding]; other site
1321369006168	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369006169	Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
1321369006170	Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656
1321369006171	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
1321369006172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707
1321369006173	AntA/AntB antirepressor; Region: AntA; cl01430
1321369006174	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
1321369006175	Protein of unknown function (DUF739); Region: DUF739; pfam05339
1321369006176	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369006177	non-specific DNA binding site [nucleotide binding]; other site
1321369006178	salt bridge; other site
1321369006179	sequence-specific DNA binding site [nucleotide binding]; other site
1321369006180	Predicted transcriptional regulator [Transcription]; Region: COG2932
1321369006181	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1321369006182	Catalytic site [active]
1321369006183	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1321369006184	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1321369006185	Int/Topo IB signature motif; other site
1321369006186	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1321369006187	putative catalytic site [active]
1321369006188	phosphate binding site [ion binding]; other site
1321369006189	metal binding site A [ion binding]; metal-binding site
1321369006190	metal binding site C [ion binding]; metal-binding site
1321369006191	metal binding site B [ion binding]; metal-binding site
1321369006192	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1321369006193	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1321369006194	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1321369006195	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1321369006196	metal binding site [ion binding]; metal-binding site
1321369006197	dimer interface [polypeptide binding]; other site
1321369006198	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1321369006199	Cation transport protein; Region: TrkH; cl17365
1321369006200	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1321369006201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369006202	Coenzyme A binding pocket [chemical binding]; other site
1321369006203	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
1321369006204	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1321369006205	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1321369006206	ring oligomerisation interface [polypeptide binding]; other site
1321369006207	ATP/Mg binding site [chemical binding]; other site
1321369006208	stacking interactions; other site
1321369006209	hinge regions; other site
1321369006210	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1321369006211	oligomerisation interface [polypeptide binding]; other site
1321369006212	mobile loop; other site
1321369006213	roof hairpin; other site
1321369006214	CAAX protease self-immunity; Region: Abi; pfam02517
1321369006215	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1321369006216	dimer interface [polypeptide binding]; other site
1321369006217	FMN binding site [chemical binding]; other site
1321369006218	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1321369006219	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1321369006220	putative active site [active]
1321369006221	catalytic triad [active]
1321369006222	putative dimer interface [polypeptide binding]; other site
1321369006223	delta-hemolysin; Provisional; Region: PRK14752
1321369006224	Accessory gene regulator B; Region: AgrB; smart00793
1321369006225	Staphylococcal AgrD protein; Region: AgrD; smart00794
1321369006226	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1321369006227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369006228	Mg2+ binding site [ion binding]; other site
1321369006229	G-X-G motif; other site
1321369006230	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1321369006231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369006232	active site
1321369006233	phosphorylation site [posttranslational modification]
1321369006234	intermolecular recognition site; other site
1321369006235	dimerization interface [polypeptide binding]; other site
1321369006236	LytTr DNA-binding domain; Region: LytTR; pfam04397
1321369006237	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1321369006238	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1321369006239	putative substrate binding site [chemical binding]; other site
1321369006240	putative ATP binding site [chemical binding]; other site
1321369006241	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1321369006242	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1321369006243	substrate binding [chemical binding]; other site
1321369006244	active site
1321369006245	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1321369006246	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1321369006247	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1321369006248	DNA binding site [nucleotide binding]
1321369006249	domain linker motif; other site
1321369006250	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1321369006251	dimerization interface [polypeptide binding]; other site
1321369006252	ligand binding site [chemical binding]; other site
1321369006253	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1321369006254	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1321369006255	CPxP  motif; other site
1321369006256	Predicted transporter component [General function prediction only]; Region: COG2391
1321369006257	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
1321369006258	Sulphur transport; Region: Sulf_transp; pfam04143
1321369006259	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1321369006260	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1321369006261	CoA binding domain; Region: CoA_binding; pfam02629
1321369006262	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1321369006263	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369006264	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369006265	ABC transporter; Region: ABC_tran_2; pfam12848
1321369006266	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1321369006267	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1321369006268	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
1321369006269	Walker A/P-loop; other site
1321369006270	ATP binding site [chemical binding]; other site
1321369006271	Q-loop/lid; other site
1321369006272	ABC transporter signature motif; other site
1321369006273	Walker B; other site
1321369006274	D-loop; other site
1321369006275	H-loop/switch region; other site
1321369006276	UGMP family protein; Validated; Region: PRK09604
1321369006277	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1321369006278	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1321369006279	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369006280	Coenzyme A binding pocket [chemical binding]; other site
1321369006281	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1321369006282	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1321369006283	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1321369006284	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1321369006285	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1321369006286	PYR/PP interface [polypeptide binding]; other site
1321369006287	dimer interface [polypeptide binding]; other site
1321369006288	TPP binding site [chemical binding]; other site
1321369006289	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1321369006290	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1321369006291	TPP-binding site [chemical binding]; other site
1321369006292	dimer interface [polypeptide binding]; other site
1321369006293	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
1321369006294	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1321369006295	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1321369006296	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1321369006297	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1321369006298	2-isopropylmalate synthase; Validated; Region: PRK00915
1321369006299	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1321369006300	active site
1321369006301	catalytic residues [active]
1321369006302	metal binding site [ion binding]; metal-binding site
1321369006303	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1321369006304	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1321369006305	tartrate dehydrogenase; Region: TTC; TIGR02089
1321369006306	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1321369006307	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1321369006308	substrate binding site [chemical binding]; other site
1321369006309	ligand binding site [chemical binding]; other site
1321369006310	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1321369006311	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1321369006312	substrate binding site [chemical binding]; other site
1321369006313	threonine dehydratase; Validated; Region: PRK08639
1321369006314	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1321369006315	tetramer interface [polypeptide binding]; other site
1321369006316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369006317	catalytic residue [active]
1321369006318	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1321369006319	putative Ile/Val binding site [chemical binding]; other site
1321369006320	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369006321	MULE transposase domain; Region: MULE; pfam10551
1321369006322	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1321369006323	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1321369006324	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1321369006325	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1321369006326	Phosphotransferase enzyme family; Region: APH; pfam01636
1321369006327	active site
1321369006328	ATP binding site [chemical binding]; other site
1321369006329	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1321369006330	substrate binding site [chemical binding]; other site
1321369006331	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1321369006332	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369006333	Coenzyme A binding pocket [chemical binding]; other site
1321369006334	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369006335	MULE transposase domain; Region: MULE; pfam10551
1321369006336	hypothetical protein; Provisional; Region: PRK04351
1321369006337	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1321369006338	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1321369006339	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1321369006340	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1321369006341	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1321369006342	RNA binding site [nucleotide binding]; other site
1321369006343	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
1321369006344	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1321369006345	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1321369006346	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1321369006347	DNA binding residues [nucleotide binding]
1321369006348	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1321369006349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369006350	ATP binding site [chemical binding]; other site
1321369006351	Mg2+ binding site [ion binding]; other site
1321369006352	G-X-G motif; other site
1321369006353	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1321369006354	anti sigma factor interaction site; other site
1321369006355	regulatory phosphorylation site [posttranslational modification]; other site
1321369006356	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1321369006357	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1321369006358	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1321369006359	PemK-like protein; Region: PemK; pfam02452
1321369006360	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1321369006361	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1321369006362	active site
1321369006363	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1321369006364	dimer interface [polypeptide binding]; other site
1321369006365	substrate binding site [chemical binding]; other site
1321369006366	catalytic residues [active]
1321369006367	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1321369006368	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1321369006369	Predicted membrane protein [Function unknown]; Region: COG3428
1321369006370	Bacterial PH domain; Region: DUF304; pfam03703
1321369006371	Bacterial PH domain; Region: DUF304; pfam03703
1321369006372	Bacterial PH domain; Region: DUF304; cl01348
1321369006373	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
1321369006374	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
1321369006375	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1321369006376	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1321369006377	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
1321369006378	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1321369006379	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1321369006380	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1321369006381	Ligand Binding Site [chemical binding]; other site
1321369006382	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369006383	dimer interface [polypeptide binding]; other site
1321369006384	phosphorylation site [posttranslational modification]
1321369006385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369006386	ATP binding site [chemical binding]; other site
1321369006387	Mg2+ binding site [ion binding]; other site
1321369006388	G-X-G motif; other site
1321369006389	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369006390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369006391	active site
1321369006392	phosphorylation site [posttranslational modification]
1321369006393	intermolecular recognition site; other site
1321369006394	dimerization interface [polypeptide binding]; other site
1321369006395	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369006396	DNA binding site [nucleotide binding]
1321369006397	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1321369006398	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1321369006399	ATP binding site [chemical binding]; other site
1321369006400	Mg++ binding site [ion binding]; other site
1321369006401	motif III; other site
1321369006402	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369006403	nucleotide binding region [chemical binding]; other site
1321369006404	ATP-binding site [chemical binding]; other site
1321369006405	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1321369006406	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1321369006407	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1321369006408	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1321369006409	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1321369006410	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1321369006411	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1321369006412	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1321369006413	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
1321369006414	putative homodimer interface [polypeptide binding]; other site
1321369006415	putative homotetramer interface [polypeptide binding]; other site
1321369006416	allosteric switch controlling residues; other site
1321369006417	putative metal binding site [ion binding]; other site
1321369006418	putative homodimer-homodimer interface [polypeptide binding]; other site
1321369006419	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1321369006420	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1321369006421	putative active site [active]
1321369006422	catalytic site [active]
1321369006423	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1321369006424	putative active site [active]
1321369006425	catalytic site [active]
1321369006426	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1321369006427	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1321369006428	Zn2+ binding site [ion binding]; other site
1321369006429	Mg2+ binding site [ion binding]; other site
1321369006430	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1321369006431	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1321369006432	thiamine phosphate binding site [chemical binding]; other site
1321369006433	active site
1321369006434	pyrophosphate binding site [ion binding]; other site
1321369006435	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1321369006436	substrate binding site [chemical binding]; other site
1321369006437	multimerization interface [polypeptide binding]; other site
1321369006438	ATP binding site [chemical binding]; other site
1321369006439	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1321369006440	dimer interface [polypeptide binding]; other site
1321369006441	substrate binding site [chemical binding]; other site
1321369006442	ATP binding site [chemical binding]; other site
1321369006443	thiaminase II; Region: salvage_TenA; TIGR04306
1321369006444	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1321369006445	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1321369006446	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1321369006447	dimer interface [polypeptide binding]; other site
1321369006448	ssDNA binding site [nucleotide binding]; other site
1321369006449	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369006450	YwpF-like protein; Region: YwpF; pfam14183
1321369006451	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1321369006452	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1321369006453	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1321369006454	hinge; other site
1321369006455	active site
1321369006456	Predicted membrane protein [Function unknown]; Region: COG4836
1321369006457	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
1321369006458	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1321369006459	gamma subunit interface [polypeptide binding]; other site
1321369006460	epsilon subunit interface [polypeptide binding]; other site
1321369006461	LBP interface [polypeptide binding]; other site
1321369006462	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1321369006463	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1321369006464	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1321369006465	alpha subunit interaction interface [polypeptide binding]; other site
1321369006466	Walker A motif; other site
1321369006467	ATP binding site [chemical binding]; other site
1321369006468	Walker B motif; other site
1321369006469	inhibitor binding site; inhibition site
1321369006470	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1321369006471	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1321369006472	core domain interface [polypeptide binding]; other site
1321369006473	delta subunit interface [polypeptide binding]; other site
1321369006474	epsilon subunit interface [polypeptide binding]; other site
1321369006475	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1321369006476	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1321369006477	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1321369006478	beta subunit interaction interface [polypeptide binding]; other site
1321369006479	Walker A motif; other site
1321369006480	ATP binding site [chemical binding]; other site
1321369006481	Walker B motif; other site
1321369006482	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1321369006483	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1321369006484	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1321369006485	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
1321369006486	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1321369006487	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1321369006488	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1321369006489	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1321369006490	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1321369006491	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1321369006492	active site
1321369006493	homodimer interface [polypeptide binding]; other site
1321369006494	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1321369006495	active site
1321369006496	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1321369006497	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1321369006498	dimer interface [polypeptide binding]; other site
1321369006499	active site
1321369006500	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1321369006501	folate binding site [chemical binding]; other site
1321369006502	hypothetical protein; Provisional; Region: PRK13690
1321369006503	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1321369006504	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1321369006505	active site
1321369006506	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1321369006507	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1321369006508	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1321369006509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369006510	S-adenosylmethionine binding site [chemical binding]; other site
1321369006511	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1321369006512	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1321369006513	RF-1 domain; Region: RF-1; pfam00472
1321369006514	thymidine kinase; Provisional; Region: PRK04296
1321369006515	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1321369006516	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1321369006517	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1321369006518	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1321369006519	RNA binding site [nucleotide binding]; other site
1321369006520	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1321369006521	multimer interface [polypeptide binding]; other site
1321369006522	Walker A motif; other site
1321369006523	ATP binding site [chemical binding]; other site
1321369006524	Walker B motif; other site
1321369006525	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1321369006526	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1321369006527	NAD binding site [chemical binding]; other site
1321369006528	catalytic residues [active]
1321369006529	Predicted transcriptional regulators [Transcription]; Region: COG1733
1321369006530	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1321369006531	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1321369006532	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1321369006533	hinge; other site
1321369006534	active site
1321369006535	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1321369006536	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1321369006537	intersubunit interface [polypeptide binding]; other site
1321369006538	active site
1321369006539	zinc binding site [ion binding]; other site
1321369006540	Na+ binding site [ion binding]; other site
1321369006541	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1321369006542	CTP synthetase; Validated; Region: pyrG; PRK05380
1321369006543	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1321369006544	Catalytic site [active]
1321369006545	active site
1321369006546	UTP binding site [chemical binding]; other site
1321369006547	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1321369006548	active site
1321369006549	putative oxyanion hole; other site
1321369006550	catalytic triad [active]
1321369006551	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1321369006552	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1321369006553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369006554	Coenzyme A binding pocket [chemical binding]; other site
1321369006555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369006556	Coenzyme A binding pocket [chemical binding]; other site
1321369006557	pantothenate kinase; Provisional; Region: PRK13317
1321369006558	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1321369006559	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1321369006560	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1321369006561	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1321369006562	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1321369006563	metal binding site [ion binding]; metal-binding site
1321369006564	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1321369006565	Predicted membrane protein [Function unknown]; Region: COG4270
1321369006566	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1321369006567	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1321369006568	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1321369006569	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1321369006570	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1321369006571	intersubunit interface [polypeptide binding]; other site
1321369006572	active site
1321369006573	catalytic residue [active]
1321369006574	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1321369006575	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1321369006576	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1321369006577	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1321369006578	dimerization interface [polypeptide binding]; other site
1321369006579	DPS ferroxidase diiron center [ion binding]; other site
1321369006580	ion pore; other site
1321369006581	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1321369006582	EVE domain; Region: EVE; cl00728
1321369006583	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1321369006584	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1321369006585	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1321369006586	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1321369006587	NAD(P) binding site [chemical binding]; other site
1321369006588	putative active site [active]
1321369006589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1321369006590	dimerization interface [polypeptide binding]; other site
1321369006591	putative DNA binding site [nucleotide binding]; other site
1321369006592	putative Zn2+ binding site [ion binding]; other site
1321369006593	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1321369006594	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1321369006595	SAP domain; Region: SAP; pfam02037
1321369006596	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1321369006597	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369006598	active site
1321369006599	motif I; other site
1321369006600	motif II; other site
1321369006601	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369006602	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1321369006603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369006604	Walker A/P-loop; other site
1321369006605	ATP binding site [chemical binding]; other site
1321369006606	Q-loop/lid; other site
1321369006607	ABC transporter signature motif; other site
1321369006608	Walker B; other site
1321369006609	D-loop; other site
1321369006610	H-loop/switch region; other site
1321369006611	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1321369006612	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1321369006613	glutaminase active site [active]
1321369006614	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1321369006615	dimer interface [polypeptide binding]; other site
1321369006616	active site
1321369006617	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1321369006618	dimer interface [polypeptide binding]; other site
1321369006619	active site
1321369006620	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1321369006621	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1321369006622	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1321369006623	active site
1321369006624	P-loop; other site
1321369006625	phosphorylation site [posttranslational modification]
1321369006626	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1321369006627	HTH domain; Region: HTH_11; pfam08279
1321369006628	Mga helix-turn-helix domain; Region: Mga; pfam05043
1321369006629	PRD domain; Region: PRD; pfam00874
1321369006630	PRD domain; Region: PRD; pfam00874
1321369006631	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1321369006632	active site
1321369006633	P-loop; other site
1321369006634	phosphorylation site [posttranslational modification]
1321369006635	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1321369006636	active site
1321369006637	phosphorylation site [posttranslational modification]
1321369006638	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369006639	active site
1321369006640	phosphorylation site [posttranslational modification]
1321369006641	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1321369006642	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1321369006643	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1321369006644	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369006645	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1321369006646	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369006647	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369006648	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369006649	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369006650	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369006651	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1321369006652	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1321369006653	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1321369006654	active site
1321369006655	substrate binding site [chemical binding]; other site
1321369006656	metal binding site [ion binding]; metal-binding site
1321369006657	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1321369006658	YbbR-like protein; Region: YbbR; pfam07949
1321369006659	TIGR00159 family protein; Region: TIGR00159
1321369006660	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1321369006661	Arginase family; Region: Arginase; cd09989
1321369006662	active site
1321369006663	Mn binding site [ion binding]; other site
1321369006664	oligomer interface [polypeptide binding]; other site
1321369006665	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1321369006666	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1321369006667	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1321369006668	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1321369006669	Walker A motif; other site
1321369006670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369006671	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369006672	putative substrate translocation pore; other site
1321369006673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369006674	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369006675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369006676	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1321369006677	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1321369006678	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1321369006679	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1321369006680	substrate binding site; other site
1321369006681	dimerization interface; other site
1321369006682	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1321369006683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1321369006684	Nucleoside recognition; Region: Gate; pfam07670
1321369006685	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1321369006686	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369006687	ABC-ATPase subunit  interface; other site
1321369006688	dimer interface [polypeptide binding]; other site
1321369006689	putative PBP binding regions; other site
1321369006690	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1321369006691	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1321369006692	ABC-ATPase subunit  interface; other site
1321369006693	dimer interface [polypeptide binding]; other site
1321369006694	putative PBP binding regions; other site
1321369006695	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1321369006696	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1321369006697	siderophore binding site; other site
1321369006698	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1321369006699	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1321369006700	dimer interface [polypeptide binding]; other site
1321369006701	active site
1321369006702	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1321369006703	substrate binding site [chemical binding]; other site
1321369006704	catalytic residue [active]
1321369006705	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1321369006706	IucA / IucC family; Region: IucA_IucC; pfam04183
1321369006707	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1321369006708	H+ Antiporter protein; Region: 2A0121; TIGR00900
1321369006709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369006710	putative substrate translocation pore; other site
1321369006711	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1321369006712	IucA / IucC family; Region: IucA_IucC; pfam04183
1321369006713	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1321369006714	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369006715	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369006716	Asp23 family; Region: Asp23; pfam03780
1321369006717	Small integral membrane protein [Function unknown]; Region: COG5547
1321369006718	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1321369006719	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1321369006720	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1321369006721	putative NAD(P) binding site [chemical binding]; other site
1321369006722	dimer interface [polypeptide binding]; other site
1321369006723	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1321369006724	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1321369006725	NAD(P) binding site [chemical binding]; other site
1321369006726	substrate binding site [chemical binding]; other site
1321369006727	dimer interface [polypeptide binding]; other site
1321369006728	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
1321369006729	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1321369006730	beta-galactosidase; Region: BGL; TIGR03356
1321369006731	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1321369006732	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1321369006733	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1321369006734	active site
1321369006735	P-loop; other site
1321369006736	phosphorylation site [posttranslational modification]
1321369006737	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1321369006738	methionine cluster; other site
1321369006739	active site
1321369006740	phosphorylation site [posttranslational modification]
1321369006741	metal binding site [ion binding]; metal-binding site
1321369006742	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1321369006743	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1321369006744	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1321369006745	putative substrate binding site [chemical binding]; other site
1321369006746	putative ATP binding site [chemical binding]; other site
1321369006747	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1321369006748	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1321369006749	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1321369006750	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1321369006751	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1321369006752	NAD-dependent deacetylase; Provisional; Region: PRK00481
1321369006753	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1321369006754	NAD+ binding site [chemical binding]; other site
1321369006755	substrate binding site [chemical binding]; other site
1321369006756	putative Zn binding site [ion binding]; other site
1321369006757	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
1321369006758	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1321369006759	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1321369006760	active site
1321369006761	catalytic tetrad [active]
1321369006762	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1321369006763	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1321369006764	DNA binding residues [nucleotide binding]
1321369006765	putative dimer interface [polypeptide binding]; other site
1321369006766	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1321369006767	substrate binding site [chemical binding]; other site
1321369006768	catalytic residues [active]
1321369006769	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1321369006770	Peptidase family M23; Region: Peptidase_M23; pfam01551
1321369006771	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1321369006772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1321369006773	active site
1321369006774	motif I; other site
1321369006775	motif II; other site
1321369006776	MAP domain; Region: MAP; pfam03642
1321369006777	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1321369006778	acetolactate synthase; Reviewed; Region: PRK08617
1321369006779	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1321369006780	PYR/PP interface [polypeptide binding]; other site
1321369006781	dimer interface [polypeptide binding]; other site
1321369006782	TPP binding site [chemical binding]; other site
1321369006783	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1321369006784	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1321369006785	TPP-binding site [chemical binding]; other site
1321369006786	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1321369006787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369006788	Walker A motif; other site
1321369006789	ATP binding site [chemical binding]; other site
1321369006790	Walker B motif; other site
1321369006791	arginine finger; other site
1321369006792	Predicted helicase [General function prediction only]; Region: COG4889
1321369006793	Predicted helicase [General function prediction only]; Region: COG4889
1321369006794	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1321369006795	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1321369006796	23S rRNA interface [nucleotide binding]; other site
1321369006797	L3 interface [polypeptide binding]; other site
1321369006798	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1321369006799	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1321369006800	dimerization interface 3.5A [polypeptide binding]; other site
1321369006801	active site
1321369006802	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1321369006803	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
1321369006804	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369006805	Walker A/P-loop; other site
1321369006806	ATP binding site [chemical binding]; other site
1321369006807	Q-loop/lid; other site
1321369006808	ABC transporter signature motif; other site
1321369006809	Walker B; other site
1321369006810	D-loop; other site
1321369006811	H-loop/switch region; other site
1321369006812	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
1321369006813	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369006814	Walker A/P-loop; other site
1321369006815	ATP binding site [chemical binding]; other site
1321369006816	Q-loop/lid; other site
1321369006817	ABC transporter signature motif; other site
1321369006818	Walker B; other site
1321369006819	D-loop; other site
1321369006820	H-loop/switch region; other site
1321369006821	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1321369006822	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1321369006823	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1321369006824	alphaNTD homodimer interface [polypeptide binding]; other site
1321369006825	alphaNTD - beta interaction site [polypeptide binding]; other site
1321369006826	alphaNTD - beta' interaction site [polypeptide binding]; other site
1321369006827	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1321369006828	30S ribosomal protein S11; Validated; Region: PRK05309
1321369006829	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1321369006830	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1321369006831	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1321369006832	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1321369006833	rRNA binding site [nucleotide binding]; other site
1321369006834	predicted 30S ribosome binding site; other site
1321369006835	adenylate kinase; Reviewed; Region: adk; PRK00279
1321369006836	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1321369006837	AMP-binding site [chemical binding]; other site
1321369006838	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1321369006839	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1321369006840	SecY translocase; Region: SecY; pfam00344
1321369006841	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1321369006842	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1321369006843	23S rRNA binding site [nucleotide binding]; other site
1321369006844	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1321369006845	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1321369006846	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1321369006847	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1321369006848	5S rRNA interface [nucleotide binding]; other site
1321369006849	L27 interface [polypeptide binding]; other site
1321369006850	23S rRNA interface [nucleotide binding]; other site
1321369006851	L5 interface [polypeptide binding]; other site
1321369006852	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1321369006853	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1321369006854	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1321369006855	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1321369006856	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1321369006857	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1321369006858	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1321369006859	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1321369006860	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1321369006861	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1321369006862	RNA binding site [nucleotide binding]; other site
1321369006863	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1321369006864	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1321369006865	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1321369006866	23S rRNA interface [nucleotide binding]; other site
1321369006867	putative translocon interaction site; other site
1321369006868	signal recognition particle (SRP54) interaction site; other site
1321369006869	L23 interface [polypeptide binding]; other site
1321369006870	trigger factor interaction site; other site
1321369006871	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1321369006872	23S rRNA interface [nucleotide binding]; other site
1321369006873	5S rRNA interface [nucleotide binding]; other site
1321369006874	putative antibiotic binding site [chemical binding]; other site
1321369006875	L25 interface [polypeptide binding]; other site
1321369006876	L27 interface [polypeptide binding]; other site
1321369006877	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1321369006878	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1321369006879	G-X-X-G motif; other site
1321369006880	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1321369006881	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1321369006882	putative translocon binding site; other site
1321369006883	protein-rRNA interface [nucleotide binding]; other site
1321369006884	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1321369006885	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1321369006886	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1321369006887	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1321369006888	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1321369006889	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1321369006890	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1321369006891	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1321369006892	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1321369006893	DNA topoisomerase III; Provisional; Region: PRK07726
1321369006894	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1321369006895	active site
1321369006896	putative interdomain interaction site [polypeptide binding]; other site
1321369006897	putative metal-binding site [ion binding]; other site
1321369006898	putative nucleotide binding site [chemical binding]; other site
1321369006899	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1321369006900	domain I; other site
1321369006901	DNA binding groove [nucleotide binding]
1321369006902	phosphate binding site [ion binding]; other site
1321369006903	domain II; other site
1321369006904	domain III; other site
1321369006905	nucleotide binding site [chemical binding]; other site
1321369006906	catalytic site [active]
1321369006907	domain IV; other site
1321369006908	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1321369006909	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369006910	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1321369006911	Coenzyme A binding pocket [chemical binding]; other site
1321369006912	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1321369006913	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1321369006914	Predicted permeases [General function prediction only]; Region: COG0679
1321369006915	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1321369006916	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1321369006917	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1321369006918	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1321369006919	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1321369006920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369006921	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369006922	putative substrate translocation pore; other site
1321369006923	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369006924	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369006925	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1321369006926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369006927	FeS/SAM binding site; other site
1321369006928	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1321369006929	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1321369006930	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1321369006931	GTP binding site; other site
1321369006932	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1321369006933	MoaE interaction surface [polypeptide binding]; other site
1321369006934	MoeB interaction surface [polypeptide binding]; other site
1321369006935	thiocarboxylated glycine; other site
1321369006936	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1321369006937	MoaE homodimer interface [polypeptide binding]; other site
1321369006938	MoaD interaction [polypeptide binding]; other site
1321369006939	active site residues [active]
1321369006940	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1321369006941	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1321369006942	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1321369006943	dimer interface [polypeptide binding]; other site
1321369006944	putative functional site; other site
1321369006945	putative MPT binding site; other site
1321369006946	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1321369006947	trimer interface [polypeptide binding]; other site
1321369006948	dimer interface [polypeptide binding]; other site
1321369006949	putative active site [active]
1321369006950	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1321369006951	MPT binding site; other site
1321369006952	trimer interface [polypeptide binding]; other site
1321369006953	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1321369006954	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1321369006955	ATP binding site [chemical binding]; other site
1321369006956	substrate interface [chemical binding]; other site
1321369006957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369006958	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1321369006959	Walker A/P-loop; other site
1321369006960	ATP binding site [chemical binding]; other site
1321369006961	Q-loop/lid; other site
1321369006962	ABC transporter signature motif; other site
1321369006963	Walker B; other site
1321369006964	D-loop; other site
1321369006965	H-loop/switch region; other site
1321369006966	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1321369006967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369006968	dimer interface [polypeptide binding]; other site
1321369006969	conserved gate region; other site
1321369006970	putative PBP binding loops; other site
1321369006971	ABC-ATPase subunit interface; other site
1321369006972	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1321369006973	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1321369006974	substrate binding pocket [chemical binding]; other site
1321369006975	membrane-bound complex binding site; other site
1321369006976	hinge residues; other site
1321369006977	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1321369006978	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369006979	Coenzyme A binding pocket [chemical binding]; other site
1321369006980	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1321369006981	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1321369006982	active site
1321369006983	dimerization interface [polypeptide binding]; other site
1321369006984	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1321369006985	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1321369006986	intersubunit interface [polypeptide binding]; other site
1321369006987	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1321369006988	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1321369006989	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1321369006990	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1321369006991	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1321369006992	alpha-gamma subunit interface [polypeptide binding]; other site
1321369006993	beta-gamma subunit interface [polypeptide binding]; other site
1321369006994	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1321369006995	gamma-beta subunit interface [polypeptide binding]; other site
1321369006996	alpha-beta subunit interface [polypeptide binding]; other site
1321369006997	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1321369006998	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1321369006999	subunit interactions [polypeptide binding]; other site
1321369007000	active site
1321369007001	flap region; other site
1321369007002	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1321369007003	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1321369007004	dimer interface [polypeptide binding]; other site
1321369007005	catalytic residues [active]
1321369007006	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1321369007007	UreF; Region: UreF; pfam01730
1321369007008	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1321369007009	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1321369007010	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369007011	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369007012	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369007013	Helix-turn-helix domain; Region: HTH_18; pfam12833
1321369007014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1321369007015	Surface antigen [General function prediction only]; Region: COG3942
1321369007016	CHAP domain; Region: CHAP; pfam05257
1321369007017	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1321369007018	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1321369007019	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1321369007020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
1321369007021	Surface antigen [General function prediction only]; Region: COG3942
1321369007022	CHAP domain; Region: CHAP; pfam05257
1321369007023	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1321369007024	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1321369007025	putative ligand binding site [chemical binding]; other site
1321369007026	putative NAD binding site [chemical binding]; other site
1321369007027	catalytic site [active]
1321369007028	hypothetical protein; Provisional; Region: PRK06753
1321369007029	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1321369007030	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1321369007031	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1321369007032	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1321369007033	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1321369007034	4Fe-4S binding domain; Region: Fer4; pfam00037
1321369007035	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1321369007036	[4Fe-4S] binding site [ion binding]; other site
1321369007037	molybdopterin cofactor binding site; other site
1321369007038	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1321369007039	molybdopterin cofactor binding site; other site
1321369007040	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1321369007041	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1321369007042	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1321369007043	active site
1321369007044	Predicted transcriptional regulator [Transcription]; Region: COG2378
1321369007045	HTH domain; Region: HTH_11; pfam08279
1321369007046	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369007047	CAAX protease self-immunity; Region: Abi; pfam02517
1321369007048	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1321369007049	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1321369007050	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1321369007051	putative active site [active]
1321369007052	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1321369007053	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1321369007054	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369007055	active site
1321369007056	motif I; other site
1321369007057	motif II; other site
1321369007058	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1321369007059	Sodium Bile acid symporter family; Region: SBF; pfam01758
1321369007060	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1321369007061	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369007062	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369007063	active site turn [active]
1321369007064	phosphorylation site [posttranslational modification]
1321369007065	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1321369007066	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1321369007067	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1321369007068	putative active site [active]
1321369007069	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1321369007070	putative hydrophobic ligand binding site [chemical binding]; other site
1321369007071	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1321369007072	oxidoreductase; Provisional; Region: PRK07985
1321369007073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369007074	NAD(P) binding site [chemical binding]; other site
1321369007075	active site
1321369007076	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1321369007077	amidohydrolase; Region: amidohydrolases; TIGR01891
1321369007078	metal binding site [ion binding]; metal-binding site
1321369007079	dimer interface [polypeptide binding]; other site
1321369007080	imidazolonepropionase; Validated; Region: PRK09356
1321369007081	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1321369007082	active site
1321369007083	urocanate hydratase; Provisional; Region: PRK05414
1321369007084	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1321369007085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1321369007086	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1321369007087	dimerization interface [polypeptide binding]; other site
1321369007088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1321369007089	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1321369007090	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1321369007091	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1321369007092	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
1321369007093	putative active site [active]
1321369007094	putative Mg binding site [ion binding]; other site
1321369007095	formimidoylglutamase; Provisional; Region: PRK13775
1321369007096	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1321369007097	putative active site [active]
1321369007098	putative metal binding site [ion binding]; other site
1321369007099	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1321369007100	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1321369007101	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369007102	active site
1321369007103	dimer interface [polypeptide binding]; other site
1321369007104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1321369007105	MOSC domain; Region: MOSC; pfam03473
1321369007106	3-alpha domain; Region: 3-alpha; pfam03475
1321369007107	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1321369007108	active site
1321369007109	catalytic residues [active]
1321369007110	Uncharacterized conserved protein [Function unknown]; Region: COG1742
1321369007111	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1321369007112	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1321369007113	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369007114	Walker A/P-loop; other site
1321369007115	ATP binding site [chemical binding]; other site
1321369007116	Q-loop/lid; other site
1321369007117	ABC transporter signature motif; other site
1321369007118	Walker B; other site
1321369007119	D-loop; other site
1321369007120	H-loop/switch region; other site
1321369007121	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1321369007122	Predicted membrane protein [Function unknown]; Region: COG3152
1321369007123	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1321369007124	active site
1321369007125	DNA binding site [nucleotide binding]
1321369007126	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
1321369007127	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1321369007128	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1321369007129	homotetramer interface [polypeptide binding]; other site
1321369007130	FMN binding site [chemical binding]; other site
1321369007131	homodimer contacts [polypeptide binding]; other site
1321369007132	putative active site [active]
1321369007133	putative substrate binding site [chemical binding]; other site
1321369007134	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1321369007135	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1321369007136	oligomer interface [polypeptide binding]; other site
1321369007137	metal binding site [ion binding]; metal-binding site
1321369007138	metal binding site [ion binding]; metal-binding site
1321369007139	putative Cl binding site [ion binding]; other site
1321369007140	aspartate ring; other site
1321369007141	basic sphincter; other site
1321369007142	hydrophobic gate; other site
1321369007143	periplasmic entrance; other site
1321369007144	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1321369007145	active site
1321369007146	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1321369007147	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1321369007148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007149	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1321369007150	putative substrate translocation pore; other site
1321369007151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007152	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1321369007153	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1321369007154	HlyD family secretion protein; Region: HlyD_3; pfam13437
1321369007155	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1321369007156	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1321369007157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007158	putative substrate translocation pore; other site
1321369007159	Predicted membrane protein [Function unknown]; Region: COG4640
1321369007160	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1321369007161	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369007162	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1321369007163	putative Zn2+ binding site [ion binding]; other site
1321369007164	putative DNA binding site [nucleotide binding]; other site
1321369007165	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1321369007166	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1321369007167	putative active site [active]
1321369007168	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1321369007169	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1321369007170	Walker A/P-loop; other site
1321369007171	ATP binding site [chemical binding]; other site
1321369007172	Q-loop/lid; other site
1321369007173	ABC transporter signature motif; other site
1321369007174	Walker B; other site
1321369007175	D-loop; other site
1321369007176	H-loop/switch region; other site
1321369007177	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1321369007178	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1321369007179	FtsX-like permease family; Region: FtsX; pfam02687
1321369007180	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369007181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369007182	active site
1321369007183	phosphorylation site [posttranslational modification]
1321369007184	intermolecular recognition site; other site
1321369007185	dimerization interface [polypeptide binding]; other site
1321369007186	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369007187	DNA binding site [nucleotide binding]
1321369007188	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1321369007189	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1321369007190	dimerization interface [polypeptide binding]; other site
1321369007191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1321369007192	dimer interface [polypeptide binding]; other site
1321369007193	phosphorylation site [posttranslational modification]
1321369007194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369007195	ATP binding site [chemical binding]; other site
1321369007196	Mg2+ binding site [ion binding]; other site
1321369007197	G-X-G motif; other site
1321369007198	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1321369007199	LytTr DNA-binding domain; Region: LytTR; smart00850
1321369007200	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1321369007201	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
1321369007202	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1321369007203	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1321369007204	L-lactate permease; Region: Lactate_perm; cl00701
1321369007205	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1321369007206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369007207	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369007208	Coenzyme A binding pocket [chemical binding]; other site
1321369007209	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1321369007210	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1321369007211	NAD(P) binding site [chemical binding]; other site
1321369007212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369007213	Coenzyme A binding pocket [chemical binding]; other site
1321369007214	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1321369007215	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369007216	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369007217	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
1321369007218	Predicted membrane protein [Function unknown]; Region: COG1511
1321369007219	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1321369007220	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1321369007221	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1321369007222	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1321369007223	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1321369007224	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1321369007225	Cl binding site [ion binding]; other site
1321369007226	oligomer interface [polypeptide binding]; other site
1321369007227	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1321369007228	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369007229	active site turn [active]
1321369007230	phosphorylation site [posttranslational modification]
1321369007231	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369007232	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1321369007233	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1321369007234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1321369007235	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1321369007236	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1321369007237	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1321369007238	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1321369007239	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
1321369007240	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369007241	MarR family; Region: MarR_2; pfam12802
1321369007242	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1321369007243	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
1321369007244	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1321369007245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007246	putative substrate translocation pore; other site
1321369007247	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1321369007248	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1321369007249	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1321369007250	DNA binding residues [nucleotide binding]
1321369007251	dimer interface [polypeptide binding]; other site
1321369007252	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1321369007253	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1321369007254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369007255	active site
1321369007256	phosphorylation site [posttranslational modification]
1321369007257	intermolecular recognition site; other site
1321369007258	dimerization interface [polypeptide binding]; other site
1321369007259	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1321369007260	DNA binding residues [nucleotide binding]
1321369007261	dimerization interface [polypeptide binding]; other site
1321369007262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1321369007263	Histidine kinase; Region: HisKA_3; pfam07730
1321369007264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369007265	ATP binding site [chemical binding]; other site
1321369007266	Mg2+ binding site [ion binding]; other site
1321369007267	G-X-G motif; other site
1321369007268	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1321369007269	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1321369007270	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1321369007271	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1321369007272	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1321369007273	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1321369007274	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1321369007275	[4Fe-4S] binding site [ion binding]; other site
1321369007276	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1321369007277	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1321369007278	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1321369007279	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1321369007280	molybdopterin cofactor binding site; other site
1321369007281	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1321369007282	active site
1321369007283	SAM binding site [chemical binding]; other site
1321369007284	homodimer interface [polypeptide binding]; other site
1321369007285	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1321369007286	[2Fe-2S] cluster binding site [ion binding]; other site
1321369007287	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1321369007288	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369007289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1321369007290	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1321369007291	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1321369007292	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1321369007293	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1321369007294	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1321369007295	putative active site [active]
1321369007296	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1321369007297	active site
1321369007298	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1321369007299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369007300	Coenzyme A binding pocket [chemical binding]; other site
1321369007301	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1321369007302	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1321369007303	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1321369007304	putative hydrophobic ligand binding site [chemical binding]; other site
1321369007305	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1321369007306	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1321369007307	intersubunit interface [polypeptide binding]; other site
1321369007308	YodA lipocalin-like domain; Region: YodA; pfam09223
1321369007309	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1321369007310	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1321369007311	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1321369007312	Thioredoxin; Region: Thioredoxin_4; cl17273
1321369007313	FemAB family; Region: FemAB; pfam02388
1321369007314	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1321369007315	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1321369007316	Walker A/P-loop; other site
1321369007317	ATP binding site [chemical binding]; other site
1321369007318	Q-loop/lid; other site
1321369007319	ABC transporter signature motif; other site
1321369007320	Walker B; other site
1321369007321	D-loop; other site
1321369007322	H-loop/switch region; other site
1321369007323	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1321369007324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369007325	dimer interface [polypeptide binding]; other site
1321369007326	conserved gate region; other site
1321369007327	putative PBP binding loops; other site
1321369007328	ABC-ATPase subunit interface; other site
1321369007329	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1321369007330	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1321369007331	substrate binding pocket [chemical binding]; other site
1321369007332	membrane-bound complex binding site; other site
1321369007333	hinge residues; other site
1321369007334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007335	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369007336	putative substrate translocation pore; other site
1321369007337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007338	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1321369007339	catalytic core [active]
1321369007340	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1321369007341	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1321369007342	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1321369007343	B domain; Region: B; pfam02216
1321369007344	B domain; Region: B; pfam02216
1321369007345	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
1321369007346	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1321369007347	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1321369007348	MULE transposase domain; Region: MULE; pfam10551
1321369007349	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1321369007350	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
1321369007351	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1321369007352	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1321369007353	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1321369007354	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1321369007355	catalytic residue [active]
1321369007356	biotin synthase; Validated; Region: PRK06256
1321369007357	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369007358	FeS/SAM binding site; other site
1321369007359	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1321369007360	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1321369007361	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1321369007362	inhibitor-cofactor binding pocket; inhibition site
1321369007363	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369007364	catalytic residue [active]
1321369007365	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1321369007366	AAA domain; Region: AAA_26; pfam13500
1321369007367	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1321369007368	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1321369007369	Walker A/P-loop; other site
1321369007370	ATP binding site [chemical binding]; other site
1321369007371	Q-loop/lid; other site
1321369007372	ABC transporter signature motif; other site
1321369007373	Walker B; other site
1321369007374	D-loop; other site
1321369007375	H-loop/switch region; other site
1321369007376	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1321369007377	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1321369007378	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369007379	Walker A/P-loop; other site
1321369007380	ATP binding site [chemical binding]; other site
1321369007381	Q-loop/lid; other site
1321369007382	ABC transporter signature motif; other site
1321369007383	Walker B; other site
1321369007384	D-loop; other site
1321369007385	H-loop/switch region; other site
1321369007386	Predicted membrane protein [Function unknown]; Region: COG2246
1321369007387	GtrA-like protein; Region: GtrA; pfam04138
1321369007388	glycerate kinase; Region: TIGR00045
1321369007389	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1321369007390	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1321369007391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007392	putative substrate translocation pore; other site
1321369007393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1321369007394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
1321369007395	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1321369007396	putative phosphoesterase; Region: acc_ester; TIGR03729
1321369007397	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1321369007398	Spore germination protein; Region: Spore_permease; cl17796
1321369007399	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1321369007400	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1321369007401	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1321369007402	Beta-lactamase; Region: Beta-lactamase; pfam00144
1321369007403	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1321369007404	extended (e) SDRs; Region: SDR_e; cd08946
1321369007405	NAD(P) binding site [chemical binding]; other site
1321369007406	active site
1321369007407	substrate binding site [chemical binding]; other site
1321369007408	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1321369007409	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1321369007410	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1321369007411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007412	putative substrate translocation pore; other site
1321369007413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369007415	dimer interface [polypeptide binding]; other site
1321369007416	conserved gate region; other site
1321369007417	ABC-ATPase subunit interface; other site
1321369007418	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1321369007419	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1321369007420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369007421	dimer interface [polypeptide binding]; other site
1321369007422	conserved gate region; other site
1321369007423	putative PBP binding loops; other site
1321369007424	ABC-ATPase subunit interface; other site
1321369007425	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1321369007426	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1321369007427	Walker A/P-loop; other site
1321369007428	ATP binding site [chemical binding]; other site
1321369007429	Q-loop/lid; other site
1321369007430	ABC transporter signature motif; other site
1321369007431	Walker B; other site
1321369007432	D-loop; other site
1321369007433	H-loop/switch region; other site
1321369007434	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1321369007435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1321369007436	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1321369007437	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1321369007438	amino acid transporter; Region: 2A0306; TIGR00909
1321369007439	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1321369007440	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1321369007441	substrate binding pocket [chemical binding]; other site
1321369007442	catalytic triad [active]
1321369007443	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1321369007444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007445	putative substrate translocation pore; other site
1321369007446	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1321369007447	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1321369007448	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369007449	Walker A/P-loop; other site
1321369007450	ATP binding site [chemical binding]; other site
1321369007451	Q-loop/lid; other site
1321369007452	ABC transporter signature motif; other site
1321369007453	Walker B; other site
1321369007454	D-loop; other site
1321369007455	H-loop/switch region; other site
1321369007456	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1321369007457	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1321369007458	oligomer interface [polypeptide binding]; other site
1321369007459	active site
1321369007460	metal binding site [ion binding]; metal-binding site
1321369007461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
1321369007462	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1321369007463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1321369007464	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1321369007465	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1321369007466	active site
1321369007467	FMN binding site [chemical binding]; other site
1321369007468	substrate binding site [chemical binding]; other site
1321369007469	3Fe-4S cluster binding site [ion binding]; other site
1321369007470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007471	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369007472	putative substrate translocation pore; other site
1321369007473	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1321369007474	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369007475	Walker A/P-loop; other site
1321369007476	ATP binding site [chemical binding]; other site
1321369007477	Q-loop/lid; other site
1321369007478	ABC transporter signature motif; other site
1321369007479	Walker B; other site
1321369007480	D-loop; other site
1321369007481	H-loop/switch region; other site
1321369007482	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1321369007483	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1321369007484	Walker A/P-loop; other site
1321369007485	ATP binding site [chemical binding]; other site
1321369007486	Q-loop/lid; other site
1321369007487	ABC transporter signature motif; other site
1321369007488	Walker B; other site
1321369007489	D-loop; other site
1321369007490	H-loop/switch region; other site
1321369007491	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1321369007492	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1321369007493	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1321369007494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369007495	dimer interface [polypeptide binding]; other site
1321369007496	conserved gate region; other site
1321369007497	putative PBP binding loops; other site
1321369007498	ABC-ATPase subunit interface; other site
1321369007499	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1321369007500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1321369007501	dimer interface [polypeptide binding]; other site
1321369007502	conserved gate region; other site
1321369007503	putative PBP binding loops; other site
1321369007504	ABC-ATPase subunit interface; other site
1321369007505	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1321369007506	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1321369007507	substrate binding site [chemical binding]; other site
1321369007508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1321369007509	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1321369007510	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1321369007511	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1321369007512	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
1321369007513	classical (c) SDRs; Region: SDR_c; cd05233
1321369007514	NAD(P) binding site [chemical binding]; other site
1321369007515	active site
1321369007516	AbgT putative transporter family; Region: ABG_transport; pfam03806
1321369007517	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1321369007518	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1321369007519	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1321369007520	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1321369007521	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1321369007522	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1321369007523	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1321369007524	classical (c) SDRs; Region: SDR_c; cd05233
1321369007525	NAD(P) binding site [chemical binding]; other site
1321369007526	active site
1321369007527	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1321369007528	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369007529	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1321369007530	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1321369007531	PLD-like domain; Region: PLDc_2; pfam13091
1321369007532	putative homodimer interface [polypeptide binding]; other site
1321369007533	putative active site [active]
1321369007534	catalytic site [active]
1321369007535	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1321369007536	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1321369007537	ATP binding site [chemical binding]; other site
1321369007538	putative Mg++ binding site [ion binding]; other site
1321369007539	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1321369007540	nucleotide binding region [chemical binding]; other site
1321369007541	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1321369007542	ATP-binding site [chemical binding]; other site
1321369007543	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1321369007544	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1321369007545	active site
1321369007546	8-oxo-dGMP binding site [chemical binding]; other site
1321369007547	nudix motif; other site
1321369007548	metal binding site [ion binding]; metal-binding site
1321369007549	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1321369007550	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1321369007551	active site
1321369007552	substrate binding site [chemical binding]; other site
1321369007553	metal binding site [ion binding]; metal-binding site
1321369007554	H+ Antiporter protein; Region: 2A0121; TIGR00900
1321369007555	legume lectins; Region: lectin_L-type; cl14058
1321369007556	homotetramer interaction site [polypeptide binding]; other site
1321369007557	carbohydrate binding site [chemical binding]; other site
1321369007558	metal binding site [ion binding]; metal-binding site
1321369007559	G5 domain; Region: G5; pfam07501
1321369007560	G5 domain; Region: G5; pfam07501
1321369007561	G5 domain; Region: G5; pfam07501
1321369007562	G5 domain; Region: G5; pfam07501
1321369007563	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1321369007564	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369007565	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369007566	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369007567	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369007568	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1321369007569	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1321369007570	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1321369007571	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1321369007572	active site
1321369007573	tetramer interface; other site
1321369007574	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369007575	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369007576	Fibronectin binding repeat; Region: Fn_bind; pfam02986
1321369007577	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1321369007578	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369007579	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369007580	Fibronectin binding repeat; Region: Fn_bind; pfam02986
1321369007581	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1321369007582	GntP family permease; Region: GntP_permease; pfam02447
1321369007583	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1321369007584	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1321369007585	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1321369007586	N- and C-terminal domain interface [polypeptide binding]; other site
1321369007587	active site
1321369007588	catalytic site [active]
1321369007589	metal binding site [ion binding]; metal-binding site
1321369007590	carbohydrate binding site [chemical binding]; other site
1321369007591	ATP binding site [chemical binding]; other site
1321369007592	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1321369007593	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1321369007594	DNA-binding site [nucleotide binding]; DNA binding site
1321369007595	FCD domain; Region: FCD; pfam07729
1321369007596	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1321369007597	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1321369007598	DNA binding residues [nucleotide binding]
1321369007599	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1321369007600	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1321369007601	synthetase active site [active]
1321369007602	NTP binding site [chemical binding]; other site
1321369007603	metal binding site [ion binding]; metal-binding site
1321369007604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1321369007605	Predicted membrane protein [Function unknown]; Region: COG1289
1321369007606	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1321369007607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007608	D-galactonate transporter; Region: 2A0114; TIGR00893
1321369007609	putative substrate translocation pore; other site
1321369007610	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1321369007611	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1321369007612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1321369007613	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1321369007614	putative substrate translocation pore; other site
1321369007615	MarR family; Region: MarR; pfam01047
1321369007616	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1321369007617	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369007618	Walker A/P-loop; other site
1321369007619	ATP binding site [chemical binding]; other site
1321369007620	Q-loop/lid; other site
1321369007621	ABC transporter signature motif; other site
1321369007622	Walker B; other site
1321369007623	D-loop; other site
1321369007624	H-loop/switch region; other site
1321369007625	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1321369007626	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1321369007627	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
1321369007628	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1321369007629	Predicted esterase [General function prediction only]; Region: COG0400
1321369007630	putative hydrolase; Provisional; Region: PRK11460
1321369007631	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1321369007632	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1321369007633	Zn binding site [ion binding]; other site
1321369007634	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1321369007635	Zn binding site [ion binding]; other site
1321369007636	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369007637	MarR family; Region: MarR; pfam01047
1321369007638	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1321369007639	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1321369007640	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1321369007641	putative metal binding site [ion binding]; other site
1321369007642	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1321369007643	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1321369007644	dimer interface [polypeptide binding]; other site
1321369007645	FMN binding site [chemical binding]; other site
1321369007646	D-lactate dehydrogenase; Provisional; Region: PRK12480
1321369007647	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1321369007648	homodimer interface [polypeptide binding]; other site
1321369007649	ligand binding site [chemical binding]; other site
1321369007650	NAD binding site [chemical binding]; other site
1321369007651	catalytic site [active]
1321369007652	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1321369007653	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1321369007654	active site
1321369007655	motif I; other site
1321369007656	motif II; other site
1321369007657	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1321369007658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1321369007659	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1321369007660	Walker A/P-loop; other site
1321369007661	ATP binding site [chemical binding]; other site
1321369007662	Q-loop/lid; other site
1321369007663	ABC transporter signature motif; other site
1321369007664	Walker B; other site
1321369007665	D-loop; other site
1321369007666	H-loop/switch region; other site
1321369007667	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1321369007668	active site
1321369007669	catalytic site [active]
1321369007670	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1321369007671	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369007672	Coenzyme A binding pocket [chemical binding]; other site
1321369007673	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1321369007674	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1321369007675	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1321369007676	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1321369007677	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1321369007678	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1321369007679	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1321369007680	EamA-like transporter family; Region: EamA; pfam00892
1321369007681	EamA-like transporter family; Region: EamA; pfam00892
1321369007682	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1321369007683	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1321369007684	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1321369007685	catalytic residues [active]
1321369007686	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1321369007687	active site
1321369007688	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1321369007689	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1321369007690	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1321369007691	active site turn [active]
1321369007692	phosphorylation site [posttranslational modification]
1321369007693	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1321369007694	HPr interaction site; other site
1321369007695	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1321369007696	active site
1321369007697	phosphorylation site [posttranslational modification]
1321369007698	pyruvate oxidase; Provisional; Region: PRK08611
1321369007699	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1321369007700	PYR/PP interface [polypeptide binding]; other site
1321369007701	tetramer interface [polypeptide binding]; other site
1321369007702	dimer interface [polypeptide binding]; other site
1321369007703	TPP binding site [chemical binding]; other site
1321369007704	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1321369007705	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1321369007706	TPP-binding site [chemical binding]; other site
1321369007707	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1321369007708	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1321369007709	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1321369007710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1321369007711	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1321369007712	putative dimerization interface [polypeptide binding]; other site
1321369007713	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1321369007714	Surface antigen [General function prediction only]; Region: COG3942
1321369007715	CHAP domain; Region: CHAP; pfam05257
1321369007716	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1321369007717	homodimer interface [polypeptide binding]; other site
1321369007718	catalytic residues [active]
1321369007719	NAD binding site [chemical binding]; other site
1321369007720	substrate binding pocket [chemical binding]; other site
1321369007721	flexible flap; other site
1321369007722	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1321369007723	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1321369007724	dimer interface [polypeptide binding]; other site
1321369007725	active site
1321369007726	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1321369007727	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1321369007728	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1321369007729	DNA binding site [nucleotide binding]
1321369007730	active site
1321369007731	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369007732	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1321369007733	Walker A motif; other site
1321369007734	ATP binding site [chemical binding]; other site
1321369007735	Walker B motif; other site
1321369007736	arginine finger; other site
1321369007737	UvrB/uvrC motif; Region: UVR; pfam02151
1321369007738	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1321369007739	Walker A motif; other site
1321369007740	ATP binding site [chemical binding]; other site
1321369007741	Walker B motif; other site
1321369007742	arginine finger; other site
1321369007743	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1321369007744	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1321369007745	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1321369007746	G1 box; other site
1321369007747	GTP/Mg2+ binding site [chemical binding]; other site
1321369007748	Switch I region; other site
1321369007749	G2 box; other site
1321369007750	G3 box; other site
1321369007751	Switch II region; other site
1321369007752	G4 box; other site
1321369007753	G5 box; other site
1321369007754	Nucleoside recognition; Region: Gate; pfam07670
1321369007755	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1321369007756	Nucleoside recognition; Region: Gate; pfam07670
1321369007757	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1321369007758	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1321369007759	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1321369007760	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369007761	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1321369007762	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1321369007763	Glutamate binding site [chemical binding]; other site
1321369007764	homodimer interface [polypeptide binding]; other site
1321369007765	NAD binding site [chemical binding]; other site
1321369007766	catalytic residues [active]
1321369007767	maltose O-acetyltransferase; Provisional; Region: PRK10092
1321369007768	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1321369007769	active site
1321369007770	substrate binding site [chemical binding]; other site
1321369007771	trimer interface [polypeptide binding]; other site
1321369007772	CoA binding site [chemical binding]; other site
1321369007773	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1321369007774	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1321369007775	metal-binding site [ion binding]
1321369007776	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1321369007777	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1321369007778	metal-binding site [ion binding]
1321369007779	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1321369007780	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1321369007781	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1321369007782	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1321369007783	metal-binding site [ion binding]
1321369007784	D-lactate dehydrogenase; Validated; Region: PRK08605
1321369007785	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1321369007786	homodimer interface [polypeptide binding]; other site
1321369007787	ligand binding site [chemical binding]; other site
1321369007788	NAD binding site [chemical binding]; other site
1321369007789	catalytic site [active]
1321369007790	transaminase; Reviewed; Region: PRK08068
1321369007791	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1321369007792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369007793	homodimer interface [polypeptide binding]; other site
1321369007794	catalytic residue [active]
1321369007795	phytoene desaturase; Region: crtI_fam; TIGR02734
1321369007796	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1321369007797	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1321369007798	active site lid residues [active]
1321369007799	substrate binding pocket [chemical binding]; other site
1321369007800	catalytic residues [active]
1321369007801	substrate-Mg2+ binding site; other site
1321369007802	aspartate-rich region 1; other site
1321369007803	aspartate-rich region 2; other site
1321369007804	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1321369007805	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1321369007806	active site
1321369007807	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1321369007808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1321369007809	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
1321369007810	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1321369007811	Surface antigen [General function prediction only]; Region: COG3942
1321369007812	CHAP domain; Region: CHAP; pfam05257
1321369007813	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1321369007814	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1321369007815	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1321369007816	catalytic triad [active]
1321369007817	catalytic triad [active]
1321369007818	oxyanion hole [active]
1321369007819	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1321369007820	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1321369007821	catalytic residue [active]
1321369007822	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1321369007823	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1321369007824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369007825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1321369007826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
1321369007827	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1321369007828	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1321369007829	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1321369007830	NmrA-like family; Region: NmrA; pfam05368
1321369007831	NADP binding site [chemical binding]; other site
1321369007832	active site
1321369007833	regulatory binding site [polypeptide binding]; other site
1321369007834	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
1321369007835	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369007836	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1321369007837	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1321369007838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1321369007839	NAD(P) binding site [chemical binding]; other site
1321369007840	active site
1321369007841	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1321369007842	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1321369007843	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1321369007844	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1321369007845	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1321369007846	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1321369007847	Nucleoside recognition; Region: Gate; pfam07670
1321369007848	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1321369007849	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1321369007850	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1321369007851	Integrase core domain; Region: rve; pfam00665
1321369007852	Class I aldolases; Region: Aldolase_Class_I; cl17187
1321369007853	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
1321369007854	Helix-turn-helix domain; Region: HTH_28; pfam13518
1321369007855	Winged helix-turn helix; Region: HTH_29; pfam13551
1321369007856	Integrase core domain; Region: rve; pfam00665
1321369007857	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1321369007858	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1321369007859	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1321369007860	catalytic residues [active]
1321369007861	catalytic nucleophile [active]
1321369007862	Presynaptic Site I dimer interface [polypeptide binding]; other site
1321369007863	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1321369007864	Synaptic Flat tetramer interface [polypeptide binding]; other site
1321369007865	Synaptic Site I dimer interface [polypeptide binding]; other site
1321369007866	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1321369007867	DNA-binding interface [nucleotide binding]; DNA binding site
1321369007868	Predicted transcriptional regulator [Transcription]; Region: COG3682
1321369007869	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1321369007870	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1321369007871	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1321369007872	beta-lactamase TEM; Provisional; Region: PRK15442
1321369007873	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1321369007874	Winged helix-turn helix; Region: HTH_29; pfam13551
1321369007875	Homeodomain-like domain; Region: HTH_32; pfam13565
1321369007876	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1321369007877	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1321369007878	Surface antigen [General function prediction only]; Region: COG3942
1321369007879	CHAP domain; Region: CHAP; pfam05257
1321369007880	ribonuclease E; Reviewed; Region: rne; PRK10811
1321369007881	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1321369007882	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1321369007883	AAA-like domain; Region: AAA_10; pfam12846
1321369007884	TcpE family; Region: TcpE; pfam12648
1321369007885	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1321369007886	Replication initiation factor; Region: Rep_trans; pfam02486
1321369007887	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1321369007888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
1321369007889	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1321369007890	Phosphotransferase enzyme family; Region: APH; pfam01636
1321369007891	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1321369007892	active site
1321369007893	ATP binding site [chemical binding]; other site
1321369007894	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1321369007895	active site
1321369007896	ATP binding site [chemical binding]; other site
1321369007897	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1321369007898	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1321369007899	quinone interaction residues [chemical binding]; other site
1321369007900	active site
1321369007901	catalytic residues [active]
1321369007902	FMN binding site [chemical binding]; other site
1321369007903	substrate binding site [chemical binding]; other site
1321369007904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1321369007905	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1321369007906	dimer interface [polypeptide binding]; other site
1321369007907	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1321369007908	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369007909	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1321369007910	Predicted acyl esterases [General function prediction only]; Region: COG2936
1321369007911	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1321369007912	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1321369007913	tetramerization interface [polypeptide binding]; other site
1321369007914	active site
1321369007915	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1321369007916	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1321369007917	active site
1321369007918	ATP-binding site [chemical binding]; other site
1321369007919	pantoate-binding site; other site
1321369007920	HXXH motif; other site
1321369007921	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1321369007922	oligomerization interface [polypeptide binding]; other site
1321369007923	active site
1321369007924	metal binding site [ion binding]; metal-binding site
1321369007925	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1321369007926	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1321369007927	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1321369007928	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1321369007929	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1321369007930	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1321369007931	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1321369007932	NAD binding site [chemical binding]; other site
1321369007933	dimer interface [polypeptide binding]; other site
1321369007934	substrate binding site [chemical binding]; other site
1321369007935	amino acid transporter; Region: 2A0306; TIGR00909
1321369007936	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1321369007937	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1321369007938	inhibitor-cofactor binding pocket; inhibition site
1321369007939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369007940	catalytic residue [active]
1321369007941	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1321369007942	catalytic residue [active]
1321369007943	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1321369007944	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1321369007945	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1321369007946	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1321369007947	acyl-activating enzyme (AAE) consensus motif; other site
1321369007948	AMP binding site [chemical binding]; other site
1321369007949	active site
1321369007950	CoA binding site [chemical binding]; other site
1321369007951	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1321369007952	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1321369007953	choline dehydrogenase; Validated; Region: PRK02106
1321369007954	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1321369007955	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1321369007956	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1321369007957	tetramerization interface [polypeptide binding]; other site
1321369007958	NAD(P) binding site [chemical binding]; other site
1321369007959	catalytic residues [active]
1321369007960	Predicted transcriptional regulators [Transcription]; Region: COG1510
1321369007961	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1321369007962	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1321369007963	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1321369007964	FeS/SAM binding site; other site
1321369007965	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
1321369007966	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1321369007967	effector binding site; other site
1321369007968	active site
1321369007969	Zn binding site [ion binding]; other site
1321369007970	glycine loop; other site
1321369007971	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1321369007972	Citrate transporter; Region: CitMHS; pfam03600
1321369007973	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1321369007974	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1321369007975	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1321369007976	Flavodoxin; Region: Flavodoxin_1; pfam00258
1321369007977	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1321369007978	FAD binding pocket [chemical binding]; other site
1321369007979	FAD binding motif [chemical binding]; other site
1321369007980	catalytic residues [active]
1321369007981	NAD binding pocket [chemical binding]; other site
1321369007982	phosphate binding motif [ion binding]; other site
1321369007983	beta-alpha-beta structure motif; other site
1321369007984	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1321369007985	catalytic residues [active]
1321369007986	dimer interface [polypeptide binding]; other site
1321369007987	FtsX-like permease family; Region: FtsX; pfam02687
1321369007988	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1321369007989	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1321369007990	Walker A/P-loop; other site
1321369007991	ATP binding site [chemical binding]; other site
1321369007992	Q-loop/lid; other site
1321369007993	ABC transporter signature motif; other site
1321369007994	Walker B; other site
1321369007995	D-loop; other site
1321369007996	H-loop/switch region; other site
1321369007997	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1321369007998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1321369007999	ATP binding site [chemical binding]; other site
1321369008000	Mg2+ binding site [ion binding]; other site
1321369008001	G-X-G motif; other site
1321369008002	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1321369008003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1321369008004	active site
1321369008005	phosphorylation site [posttranslational modification]
1321369008006	intermolecular recognition site; other site
1321369008007	dimerization interface [polypeptide binding]; other site
1321369008008	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1321369008009	DNA binding site [nucleotide binding]
1321369008010	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1321369008011	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1321369008012	dimer interface [polypeptide binding]; other site
1321369008013	active site
1321369008014	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1321369008015	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1321369008016	MarR family; Region: MarR_2; pfam12802
1321369008017	Predicted esterase [General function prediction only]; Region: COG0627
1321369008018	S-formylglutathione hydrolase; Region: PLN02442
1321369008019	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1321369008020	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1321369008021	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1321369008022	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1321369008023	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1321369008024	ligand binding site [chemical binding]; other site
1321369008025	flexible hinge region; other site
1321369008026	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1321369008027	carbamate kinase; Reviewed; Region: PRK12686
1321369008028	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1321369008029	putative substrate binding site [chemical binding]; other site
1321369008030	nucleotide binding site [chemical binding]; other site
1321369008031	nucleotide binding site [chemical binding]; other site
1321369008032	homodimer interface [polypeptide binding]; other site
1321369008033	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1321369008034	ornithine carbamoyltransferase; Validated; Region: PRK02102
1321369008035	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1321369008036	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1321369008037	arginine deiminase; Provisional; Region: PRK01388
1321369008038	Arginine repressor [Transcription]; Region: ArgR; COG1438
1321369008039	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1321369008040	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1321369008041	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1321369008042	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1321369008043	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1321369008044	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1321369008045	active site
1321369008046	Zn binding site [ion binding]; other site
1321369008047	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1321369008048	HTH domain; Region: HTH_11; pfam08279
1321369008049	PRD domain; Region: PRD; pfam00874
1321369008050	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1321369008051	active site
1321369008052	P-loop; other site
1321369008053	phosphorylation site [posttranslational modification]
1321369008054	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369008055	active site
1321369008056	phosphorylation site [posttranslational modification]
1321369008057	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1321369008058	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1321369008059	active site
1321369008060	P-loop; other site
1321369008061	phosphorylation site [posttranslational modification]
1321369008062	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1321369008063	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1321369008064	active site
1321369008065	phosphorylation site [posttranslational modification]
1321369008066	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1321369008067	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1321369008068	Predicted membrane protein [Function unknown]; Region: COG1511
1321369008069	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1321369008070	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1321369008071	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
1321369008072	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1321369008073	CHAP domain; Region: CHAP; pfam05257
1321369008074	Isochorismatase family; Region: Isochorismatase; pfam00857
1321369008075	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1321369008076	catalytic triad [active]
1321369008077	conserved cis-peptide bond; other site
1321369008078	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1321369008079	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1321369008080	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1321369008081	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1321369008082	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1321369008083	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1321369008084	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1321369008085	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1321369008086	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1321369008087	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1321369008088	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1321369008089	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1321369008090	SecY translocase; Region: SecY; pfam00344
1321369008091	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1321369008092	legume lectins; Region: lectin_L-type; cd01951
1321369008093	homotetramer interaction site [polypeptide binding]; other site
1321369008094	carbohydrate binding site [chemical binding]; other site
1321369008095	metal binding site [ion binding]; metal-binding site
1321369008096	Putative Ig domain; Region: He_PIG; pfam05345
1321369008097	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1321369008098	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1321369008099	methionine sulfoxide reductase A; Provisional; Region: PRK05528
1321369008100	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1321369008101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1321369008102	Coenzyme A binding pocket [chemical binding]; other site
1321369008103	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1321369008104	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1321369008105	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1321369008106	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1321369008107	Chain length determinant protein; Region: Wzz; cl15801
1321369008108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1321369008109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1321369008110	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
1321369008111	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1321369008112	DXD motif; other site
1321369008113	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
1321369008114	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1321369008115	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1321369008116	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1321369008117	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1321369008118	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1321369008119	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1321369008120	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1321369008121	metal binding site [ion binding]; metal-binding site
1321369008122	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1321369008123	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1321369008124	substrate binding site [chemical binding]; other site
1321369008125	glutamase interaction surface [polypeptide binding]; other site
1321369008126	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1321369008127	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1321369008128	catalytic residues [active]
1321369008129	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
1321369008130	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1321369008131	putative active site [active]
1321369008132	oxyanion strand; other site
1321369008133	catalytic triad [active]
1321369008134	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1321369008135	putative active site pocket [active]
1321369008136	4-fold oligomerization interface [polypeptide binding]; other site
1321369008137	metal binding residues [ion binding]; metal-binding site
1321369008138	3-fold/trimer interface [polypeptide binding]; other site
1321369008139	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1321369008140	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1321369008141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1321369008142	homodimer interface [polypeptide binding]; other site
1321369008143	catalytic residue [active]
1321369008144	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1321369008145	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1321369008146	NAD binding site [chemical binding]; other site
1321369008147	dimerization interface [polypeptide binding]; other site
1321369008148	product binding site; other site
1321369008149	substrate binding site [chemical binding]; other site
1321369008150	zinc binding site [ion binding]; other site
1321369008151	catalytic residues [active]
1321369008152	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
1321369008153	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1321369008154	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
1321369008155	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1321369008156	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1321369008157	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1321369008158	putative active site [active]
1321369008159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1321369008160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1321369008161	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1321369008162	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1321369008163	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369008164	Walker A/P-loop; other site
1321369008165	ATP binding site [chemical binding]; other site
1321369008166	Q-loop/lid; other site
1321369008167	ABC transporter signature motif; other site
1321369008168	Walker B; other site
1321369008169	D-loop; other site
1321369008170	H-loop/switch region; other site
1321369008171	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1321369008172	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1321369008173	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1321369008174	Walker A/P-loop; other site
1321369008175	ATP binding site [chemical binding]; other site
1321369008176	Q-loop/lid; other site
1321369008177	ABC transporter signature motif; other site
1321369008178	Walker B; other site
1321369008179	D-loop; other site
1321369008180	H-loop/switch region; other site
1321369008181	hypothetical protein; Provisional; Region: PRK13661
1321369008182	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1321369008183	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1321369008184	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1321369008185	Strictosidine synthase; Region: Str_synth; pfam03088
1321369008186	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1321369008187	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1321369008188	active site residue [active]
1321369008189	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1321369008190	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1321369008191	putative substrate binding pocket [chemical binding]; other site
1321369008192	AC domain interface; other site
1321369008193	catalytic triad [active]
1321369008194	AB domain interface; other site
1321369008195	interchain disulfide; other site
1321369008196	DinB superfamily; Region: DinB_2; pfam12867
1321369008197	Collagen binding domain; Region: Collagen_bind; pfam05737
1321369008198	Cna protein B-type domain; Region: Cna_B; pfam05738
1321369008199	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1321369008200	domain interaction interfaces [polypeptide binding]; other site
1321369008201	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1321369008202	domain interaction interfaces [polypeptide binding]; other site
1321369008203	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1321369008204	domain interaction interfaces [polypeptide binding]; other site
1321369008205	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1321369008206	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1321369008207	transmembrane helices; other site
1321369008208	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1321369008209	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1321369008210	hypothetical protein; Provisional; Region: PRK07758
1321369008211	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1321369008212	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1321369008213	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1321369008214	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1321369008215	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1321369008216	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1321369008217	Walker A/P-loop; other site
1321369008218	ATP binding site [chemical binding]; other site
1321369008219	Q-loop/lid; other site
1321369008220	ABC transporter signature motif; other site
1321369008221	Walker B; other site
1321369008222	D-loop; other site
1321369008223	H-loop/switch region; other site
1321369008224	FtsX-like permease family; Region: FtsX; pfam02687
1321369008225	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1321369008226	active site
1321369008227	catalytic residues [active]
1321369008228	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1321369008229	DNA-binding site [nucleotide binding]; DNA binding site
1321369008230	RNA-binding motif; other site
1321369008231	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1321369008232	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1321369008233	non-specific DNA binding site [nucleotide binding]; other site
1321369008234	salt bridge; other site
1321369008235	sequence-specific DNA binding site [nucleotide binding]; other site
1321369008236	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1321369008237	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1321369008238	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1321369008239	ParB-like nuclease domain; Region: ParBc; pfam02195
1321369008240	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1321369008241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1321369008242	S-adenosylmethionine binding site [chemical binding]; other site
1321369008243	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1321369008244	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1321369008245	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1321369008246	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1321369008247	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1321369008248	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1321369008249	G1 box; other site
1321369008250	GTP/Mg2+ binding site [chemical binding]; other site
1321369008251	Switch I region; other site
1321369008252	G2 box; other site
1321369008253	Switch II region; other site
1321369008254	G3 box; other site
1321369008255	G4 box; other site
1321369008256	G5 box; other site
1321369008257	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1321369008258	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1321369008259	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399