-- dump date   	20140620_073536
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
93062000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
93062000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
93062000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062000004	Walker A motif; other site
93062000005	ATP binding site [chemical binding]; other site
93062000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
93062000007	Walker B motif; other site
93062000008	arginine finger; other site
93062000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
93062000010	DnaA box-binding interface [nucleotide binding]; other site
93062000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
93062000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
93062000013	putative DNA binding surface [nucleotide binding]; other site
93062000014	dimer interface [polypeptide binding]; other site
93062000015	beta-clamp/clamp loader binding surface; other site
93062000016	beta-clamp/translesion DNA polymerase binding surface; other site
93062000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
93062000018	recF protein; Region: recf; TIGR00611
93062000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
93062000020	Walker A/P-loop; other site
93062000021	ATP binding site [chemical binding]; other site
93062000022	Q-loop/lid; other site
93062000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062000024	ABC transporter signature motif; other site
93062000025	Walker B; other site
93062000026	D-loop; other site
93062000027	H-loop/switch region; other site
93062000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
93062000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062000030	Mg2+ binding site [ion binding]; other site
93062000031	G-X-G motif; other site
93062000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
93062000033	anchoring element; other site
93062000034	dimer interface [polypeptide binding]; other site
93062000035	ATP binding site [chemical binding]; other site
93062000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
93062000037	active site
93062000038	putative metal-binding site [ion binding]; other site
93062000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
93062000040	DNA gyrase subunit A; Validated; Region: PRK05560
93062000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
93062000042	CAP-like domain; other site
93062000043	active site
93062000044	primary dimer interface [polypeptide binding]; other site
93062000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062000051	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
93062000052	putative substrate binding site [chemical binding]; other site
93062000053	putative ATP binding site [chemical binding]; other site
93062000054	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
93062000055	active sites [active]
93062000056	tetramer interface [polypeptide binding]; other site
93062000057	seryl-tRNA synthetase; Provisional; Region: PRK05431
93062000058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
93062000059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
93062000060	dimer interface [polypeptide binding]; other site
93062000061	active site
93062000062	motif 1; other site
93062000063	motif 2; other site
93062000064	motif 3; other site
93062000065	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
93062000066	Predicted membrane protein [Function unknown]; Region: COG4392
93062000067	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
93062000068	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
93062000069	Predicted membrane protein [Function unknown]; Region: COG4241
93062000070	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
93062000071	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
93062000072	DHH family; Region: DHH; pfam01368
93062000073	DHHA1 domain; Region: DHHA1; pfam02272
93062000074	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
93062000075	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
93062000076	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
93062000077	replicative DNA helicase; Region: DnaB; TIGR00665
93062000078	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
93062000079	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
93062000080	Walker A motif; other site
93062000081	ATP binding site [chemical binding]; other site
93062000082	Walker B motif; other site
93062000083	DNA binding loops [nucleotide binding]
93062000084	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
93062000085	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
93062000086	GDP-binding site [chemical binding]; other site
93062000087	ACT binding site; other site
93062000088	IMP binding site; other site
93062000089	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062000090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062000091	active site
93062000092	phosphorylation site [posttranslational modification]
93062000093	intermolecular recognition site; other site
93062000094	dimerization interface [polypeptide binding]; other site
93062000095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062000096	DNA binding site [nucleotide binding]
93062000097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
93062000098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
93062000099	dimerization interface [polypeptide binding]; other site
93062000100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
93062000101	putative active site [active]
93062000102	heme pocket [chemical binding]; other site
93062000103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062000104	dimer interface [polypeptide binding]; other site
93062000105	phosphorylation site [posttranslational modification]
93062000106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062000107	ATP binding site [chemical binding]; other site
93062000108	Mg2+ binding site [ion binding]; other site
93062000109	G-X-G motif; other site
93062000110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
93062000111	YycH protein; Region: YycH; pfam07435
93062000112	YycH protein; Region: YycI; cl02015
93062000113	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
93062000114	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
93062000115	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
93062000116	putative active site [active]
93062000117	putative metal binding site [ion binding]; other site
93062000118	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
93062000119	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
93062000120	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
93062000121	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
93062000122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
93062000123	Integrase core domain; Region: rve; pfam00665
93062000124	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
93062000125	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
93062000126	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
93062000127	putative active site [active]
93062000128	catalytic site [active]
93062000129	putative metal binding site [ion binding]; other site
93062000130	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
93062000131	putative active site [active]
93062000132	putative catalytic site [active]
93062000133	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
93062000134	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
93062000135	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
93062000136	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
93062000137	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
93062000138	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
93062000139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
93062000140	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
93062000141	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
93062000142	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
93062000143	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
93062000144	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
93062000145	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
93062000146	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
93062000147	catalytic residues [active]
93062000148	catalytic nucleophile [active]
93062000149	Recombinase; Region: Recombinase; pfam07508
93062000150	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
93062000151	Domain of unknown function (DUF927); Region: DUF927; pfam06048
93062000152	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
93062000153	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
93062000154	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062000155	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062000156	active site residue [active]
93062000157	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062000158	active site residue [active]
93062000159	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
93062000160	CPxP  motif; other site
93062000161	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
93062000162	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
93062000163	putative homodimer interface [polypeptide binding]; other site
93062000164	putative homotetramer interface [polypeptide binding]; other site
93062000165	putative metal binding site [ion binding]; other site
93062000166	putative homodimer-homodimer interface [polypeptide binding]; other site
93062000167	putative allosteric switch controlling residues; other site
93062000168	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
93062000169	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062000170	legume lectins; Region: lectin_L-type; cl14058
93062000171	homotetramer interaction site [polypeptide binding]; other site
93062000172	carbohydrate binding site [chemical binding]; other site
93062000173	metal binding site [ion binding]; metal-binding site
93062000174	G5 domain; Region: G5; pfam07501
93062000175	G5 domain; Region: G5; pfam07501
93062000176	G5 domain; Region: G5; pfam07501
93062000177	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
93062000178	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
93062000179	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062000180	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
93062000181	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
93062000182	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
93062000183	phosphate binding site [ion binding]; other site
93062000184	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
93062000185	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
93062000186	putative homodimer interface [polypeptide binding]; other site
93062000187	putative homotetramer interface [polypeptide binding]; other site
93062000188	putative metal binding site [ion binding]; other site
93062000189	putative homodimer-homodimer interface [polypeptide binding]; other site
93062000190	putative allosteric switch controlling residues; other site
93062000191	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062000192	active site residue [active]
93062000193	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
93062000194	CPxP  motif; other site
93062000195	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
93062000196	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
93062000197	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
93062000198	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062000199	active site residue [active]
93062000200	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
93062000201	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
93062000202	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
93062000203	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
93062000204	FMN binding site [chemical binding]; other site
93062000205	active site
93062000206	catalytic residues [active]
93062000207	substrate binding site [chemical binding]; other site
93062000208	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
93062000209	H+ Antiporter protein; Region: 2A0121; TIGR00900
93062000210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000211	putative substrate translocation pore; other site
93062000212	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
93062000213	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
93062000214	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062000215	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062000216	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
93062000217	dimerization interface [polypeptide binding]; other site
93062000218	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062000219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062000220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
93062000221	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
93062000222	Part of AAA domain; Region: AAA_19; pfam13245
93062000223	AAA domain; Region: AAA_12; pfam13087
93062000224	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
93062000225	active site
93062000226	catalytic site [active]
93062000227	putative metal binding site [ion binding]; other site
93062000228	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062000229	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062000230	Protein of unknown function, DUF576; Region: DUF576; cl04553
93062000231	Protein of unknown function, DUF576; Region: DUF576; cl04553
93062000232	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062000233	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
93062000234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
93062000235	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
93062000236	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
93062000237	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
93062000238	metal binding site [ion binding]; metal-binding site
93062000239	dimer interface [polypeptide binding]; other site
93062000240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000241	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062000242	putative substrate translocation pore; other site
93062000243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000244	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
93062000245	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
93062000246	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
93062000247	PhoU domain; Region: PhoU; pfam01895
93062000248	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
93062000249	EamA-like transporter family; Region: EamA; pfam00892
93062000250	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
93062000251	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062000252	DNA-binding site [nucleotide binding]; DNA binding site
93062000253	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062000254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062000255	homodimer interface [polypeptide binding]; other site
93062000256	catalytic residue [active]
93062000257	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
93062000258	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
93062000259	L-lactate permease; Region: Lactate_perm; cl00701
93062000260	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062000261	B domain; Region: B; pfam02216
93062000262	B domain; Region: B; pfam02216
93062000263	B domain; Region: B; pfam02216
93062000264	B domain; Region: B; pfam02216
93062000265	B domain; Region: B; pfam02216
93062000266	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062000267	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062000268	Transcriptional regulators [Transcription]; Region: MarR; COG1846
93062000269	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062000270	Transcriptional regulators [Transcription]; Region: MarR; COG1846
93062000271	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
93062000272	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062000273	ABC-ATPase subunit  interface; other site
93062000274	dimer interface [polypeptide binding]; other site
93062000275	putative PBP binding regions; other site
93062000276	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
93062000277	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062000278	ABC-ATPase subunit  interface; other site
93062000279	dimer interface [polypeptide binding]; other site
93062000280	putative PBP binding regions; other site
93062000281	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
93062000282	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
93062000283	siderophore binding site; other site
93062000284	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
93062000285	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
93062000286	dimer interface [polypeptide binding]; other site
93062000287	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062000288	catalytic residue [active]
93062000289	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
93062000290	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
93062000291	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
93062000292	IucA / IucC family; Region: IucA_IucC; pfam04183
93062000293	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
93062000294	drug efflux system protein MdtG; Provisional; Region: PRK09874
93062000295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000296	putative substrate translocation pore; other site
93062000297	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
93062000298	IucA / IucC family; Region: IucA_IucC; pfam04183
93062000299	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
93062000300	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
93062000301	IucA / IucC family; Region: IucA_IucC; pfam04183
93062000302	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
93062000303	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
93062000304	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
93062000305	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
93062000306	dimer interface [polypeptide binding]; other site
93062000307	active site
93062000308	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
93062000309	catalytic residues [active]
93062000310	substrate binding site [chemical binding]; other site
93062000311	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
93062000312	ParB-like nuclease domain; Region: ParBc; pfam02195
93062000313	acetoin reductase; Validated; Region: PRK08643
93062000314	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
93062000315	NAD binding site [chemical binding]; other site
93062000316	homotetramer interface [polypeptide binding]; other site
93062000317	homodimer interface [polypeptide binding]; other site
93062000318	active site
93062000319	substrate binding site [chemical binding]; other site
93062000320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062000321	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
93062000322	NAD(P) binding site [chemical binding]; other site
93062000323	active site
93062000324	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
93062000325	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062000326	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
93062000327	putative ADP-binding pocket [chemical binding]; other site
93062000328	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
93062000329	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
93062000330	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
93062000331	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
93062000332	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
93062000333	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
93062000334	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062000335	DNA-binding site [nucleotide binding]; DNA binding site
93062000336	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
93062000337	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
93062000338	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062000339	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
93062000340	intersubunit interface [polypeptide binding]; other site
93062000341	active site
93062000342	catalytic residue [active]
93062000343	phosphopentomutase; Provisional; Region: PRK05362
93062000344	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
93062000345	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
93062000346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062000347	dimer interface [polypeptide binding]; other site
93062000348	conserved gate region; other site
93062000349	putative PBP binding loops; other site
93062000350	ABC-ATPase subunit interface; other site
93062000351	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
93062000352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062000353	dimer interface [polypeptide binding]; other site
93062000354	conserved gate region; other site
93062000355	ABC-ATPase subunit interface; other site
93062000356	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
93062000357	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
93062000358	Walker A/P-loop; other site
93062000359	ATP binding site [chemical binding]; other site
93062000360	Q-loop/lid; other site
93062000361	ABC transporter signature motif; other site
93062000362	Walker B; other site
93062000363	D-loop; other site
93062000364	H-loop/switch region; other site
93062000365	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
93062000366	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
93062000367	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
93062000368	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
93062000369	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
93062000370	active site
93062000371	metal binding site [ion binding]; metal-binding site
93062000372	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
93062000373	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
93062000374	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
93062000375	putative catalytic cysteine [active]
93062000376	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
93062000377	putative active site [active]
93062000378	metal binding site [ion binding]; metal-binding site
93062000379	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
93062000380	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
93062000381	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
93062000382	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
93062000383	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
93062000384	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
93062000385	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
93062000386	NAD(P) binding site [chemical binding]; other site
93062000387	homodimer interface [polypeptide binding]; other site
93062000388	substrate binding site [chemical binding]; other site
93062000389	active site
93062000390	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
93062000391	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
93062000392	NAD(P) binding site [chemical binding]; other site
93062000393	homodimer interface [polypeptide binding]; other site
93062000394	substrate binding site [chemical binding]; other site
93062000395	active site
93062000396	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
93062000397	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
93062000398	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
93062000399	putative NAD(P) binding site [chemical binding]; other site
93062000400	active site
93062000401	putative substrate binding site [chemical binding]; other site
93062000402	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
93062000403	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
93062000404	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
93062000405	active site
93062000406	homodimer interface [polypeptide binding]; other site
93062000407	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
93062000408	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
93062000409	trimer interface [polypeptide binding]; other site
93062000410	active site
93062000411	substrate binding site [chemical binding]; other site
93062000412	CoA binding site [chemical binding]; other site
93062000413	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062000414	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
93062000415	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
93062000416	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062000417	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
93062000418	Bacterial sugar transferase; Region: Bac_transf; pfam02397
93062000419	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
93062000420	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
93062000421	putative NAD(P) binding site [chemical binding]; other site
93062000422	active site
93062000423	putative substrate binding site [chemical binding]; other site
93062000424	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
93062000425	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
93062000426	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
93062000427	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
93062000428	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
93062000429	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
93062000430	active site
93062000431	homodimer interface [polypeptide binding]; other site
93062000432	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
93062000433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
93062000434	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
93062000435	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
93062000436	NAD(P) binding site [chemical binding]; other site
93062000437	catalytic residues [active]
93062000438	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
93062000439	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
93062000440	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
93062000441	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
93062000442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
93062000443	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
93062000444	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
93062000445	active site
93062000446	Uncharacterized conserved protein [Function unknown]; Region: COG5609
93062000447	formate dehydrogenase; Provisional; Region: PRK07574
93062000448	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
93062000449	dimerization interface [polypeptide binding]; other site
93062000450	ligand binding site [chemical binding]; other site
93062000451	NAD binding site [chemical binding]; other site
93062000452	catalytic site [active]
93062000453	putative transporter; Provisional; Region: PRK10054
93062000454	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
93062000455	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
93062000456	acyl-activating enzyme (AAE) consensus motif; other site
93062000457	AMP binding site [chemical binding]; other site
93062000458	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
93062000459	Condensation domain; Region: Condensation; pfam00668
93062000460	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
93062000461	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
93062000462	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
93062000463	acyl-activating enzyme (AAE) consensus motif; other site
93062000464	AMP binding site [chemical binding]; other site
93062000465	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
93062000466	thioester reductase domain; Region: Thioester-redct; TIGR01746
93062000467	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062000468	NAD(P) binding site [chemical binding]; other site
93062000469	active site
93062000470	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
93062000471	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
93062000472	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
93062000473	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
93062000474	nucleotide binding site [chemical binding]; other site
93062000475	N-acetyl-L-glutamate binding site [chemical binding]; other site
93062000476	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
93062000477	heterotetramer interface [polypeptide binding]; other site
93062000478	active site pocket [active]
93062000479	cleavage site
93062000480	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
93062000481	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
93062000482	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
93062000483	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
93062000484	inhibitor-cofactor binding pocket; inhibition site
93062000485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062000486	catalytic residue [active]
93062000487	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
93062000488	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
93062000489	Isochorismatase family; Region: Isochorismatase; pfam00857
93062000490	catalytic triad [active]
93062000491	conserved cis-peptide bond; other site
93062000492	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
93062000493	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
93062000494	dimer interface [polypeptide binding]; other site
93062000495	PYR/PP interface [polypeptide binding]; other site
93062000496	TPP binding site [chemical binding]; other site
93062000497	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
93062000498	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
93062000499	TPP-binding site [chemical binding]; other site
93062000500	dimer interface [polypeptide binding]; other site
93062000501	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062000502	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
93062000503	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062000504	active site turn [active]
93062000505	phosphorylation site [posttranslational modification]
93062000506	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
93062000507	HPr interaction site; other site
93062000508	glycerol kinase (GK) interaction site [polypeptide binding]; other site
93062000509	active site
93062000510	phosphorylation site [posttranslational modification]
93062000511	Uncharacterized conserved protein [Function unknown]; Region: COG3589
93062000512	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
93062000513	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
93062000514	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
93062000515	putative active site [active]
93062000516	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
93062000517	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062000518	active site turn [active]
93062000519	phosphorylation site [posttranslational modification]
93062000520	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062000521	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
93062000522	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
93062000523	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
93062000524	putative active site [active]
93062000525	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
93062000526	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
93062000527	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062000528	ATP binding site [chemical binding]; other site
93062000529	putative Mg++ binding site [ion binding]; other site
93062000530	RES domain; Region: RES; pfam08808
93062000531	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
93062000532	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062000533	Walker A/P-loop; other site
93062000534	ATP binding site [chemical binding]; other site
93062000535	Q-loop/lid; other site
93062000536	ABC transporter signature motif; other site
93062000537	Walker B; other site
93062000538	D-loop; other site
93062000539	H-loop/switch region; other site
93062000540	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
93062000541	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062000542	Walker A/P-loop; other site
93062000543	ATP binding site [chemical binding]; other site
93062000544	Q-loop/lid; other site
93062000545	ABC transporter signature motif; other site
93062000546	Walker B; other site
93062000547	D-loop; other site
93062000548	H-loop/switch region; other site
93062000549	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
93062000550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062000551	dimer interface [polypeptide binding]; other site
93062000552	conserved gate region; other site
93062000553	putative PBP binding loops; other site
93062000554	ABC-ATPase subunit interface; other site
93062000555	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
93062000556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062000557	dimer interface [polypeptide binding]; other site
93062000558	conserved gate region; other site
93062000559	ABC-ATPase subunit interface; other site
93062000560	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
93062000561	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
93062000562	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
93062000563	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
93062000564	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
93062000565	Protein of unknown function, DUF576; Region: DUF576; cl04553
93062000566	azoreductase; Reviewed; Region: PRK00170
93062000567	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
93062000568	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
93062000569	Peptidase family M23; Region: Peptidase_M23; pfam01551
93062000570	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
93062000571	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
93062000572	Walker A/P-loop; other site
93062000573	ATP binding site [chemical binding]; other site
93062000574	Q-loop/lid; other site
93062000575	ABC transporter signature motif; other site
93062000576	Walker B; other site
93062000577	D-loop; other site
93062000578	H-loop/switch region; other site
93062000579	TOBE domain; Region: TOBE; pfam03459
93062000580	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
93062000581	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
93062000582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062000583	dimer interface [polypeptide binding]; other site
93062000584	conserved gate region; other site
93062000585	ABC-ATPase subunit interface; other site
93062000586	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
93062000587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062000588	dimer interface [polypeptide binding]; other site
93062000589	conserved gate region; other site
93062000590	putative PBP binding loops; other site
93062000591	ABC-ATPase subunit interface; other site
93062000592	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
93062000593	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
93062000594	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
93062000595	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
93062000596	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
93062000597	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
93062000598	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
93062000599	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
93062000600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
93062000601	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
93062000602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000603	putative substrate translocation pore; other site
93062000604	Response regulator receiver domain; Region: Response_reg; pfam00072
93062000605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062000606	active site
93062000607	phosphorylation site [posttranslational modification]
93062000608	intermolecular recognition site; other site
93062000609	dimerization interface [polypeptide binding]; other site
93062000610	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
93062000611	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
93062000612	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
93062000613	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
93062000614	Histidine kinase; Region: His_kinase; pfam06580
93062000615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062000616	ATP binding site [chemical binding]; other site
93062000617	Mg2+ binding site [ion binding]; other site
93062000618	G-X-G motif; other site
93062000619	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
93062000620	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
93062000621	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
93062000622	Pyruvate formate lyase 1; Region: PFL1; cd01678
93062000623	coenzyme A binding site [chemical binding]; other site
93062000624	active site
93062000625	catalytic residues [active]
93062000626	glycine loop; other site
93062000627	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
93062000628	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062000629	FeS/SAM binding site; other site
93062000630	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
93062000631	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
93062000632	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
93062000633	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
93062000634	putative active site [active]
93062000635	catalytic site [active]
93062000636	putative metal binding site [ion binding]; other site
93062000637	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
93062000638	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
93062000639	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
93062000640	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
93062000641	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
93062000642	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
93062000643	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
93062000644	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
93062000645	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
93062000646	dimer interface [polypeptide binding]; other site
93062000647	active site
93062000648	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
93062000649	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
93062000650	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
93062000651	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
93062000652	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
93062000653	substrate binding site [chemical binding]; other site
93062000654	oxyanion hole (OAH) forming residues; other site
93062000655	trimer interface [polypeptide binding]; other site
93062000656	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
93062000657	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
93062000658	active site
93062000659	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
93062000660	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
93062000661	acyl-activating enzyme (AAE) consensus motif; other site
93062000662	AMP binding site [chemical binding]; other site
93062000663	active site
93062000664	CoA binding site [chemical binding]; other site
93062000665	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
93062000666	Coenzyme A transferase; Region: CoA_trans; smart00882
93062000667	Coenzyme A transferase; Region: CoA_trans; cl17247
93062000668	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
93062000669	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
93062000670	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
93062000671	Uncharacterized conserved protein [Function unknown]; Region: COG3189
93062000672	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
93062000673	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
93062000674	heme-binding site [chemical binding]; other site
93062000675	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
93062000676	FAD binding pocket [chemical binding]; other site
93062000677	FAD binding motif [chemical binding]; other site
93062000678	phosphate binding motif [ion binding]; other site
93062000679	beta-alpha-beta structure motif; other site
93062000680	NAD binding pocket [chemical binding]; other site
93062000681	Heme binding  pocket [chemical binding]; other site
93062000682	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
93062000683	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
93062000684	tetramer (dimer of dimers) interface [polypeptide binding]; other site
93062000685	NAD binding site [chemical binding]; other site
93062000686	dimer interface [polypeptide binding]; other site
93062000687	substrate binding site [chemical binding]; other site
93062000688	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
93062000689	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062000690	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062000691	active site turn [active]
93062000692	phosphorylation site [posttranslational modification]
93062000693	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
93062000694	active site
93062000695	tetramer interface [polypeptide binding]; other site
93062000696	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
93062000697	Mga helix-turn-helix domain; Region: Mga; pfam05043
93062000698	PRD domain; Region: PRD; pfam00874
93062000699	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
93062000700	active site
93062000701	P-loop; other site
93062000702	phosphorylation site [posttranslational modification]
93062000703	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062000704	active site
93062000705	phosphorylation site [posttranslational modification]
93062000706	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062000707	active site
93062000708	phosphorylation site [posttranslational modification]
93062000709	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
93062000710	active site
93062000711	P-loop; other site
93062000712	phosphorylation site [posttranslational modification]
93062000713	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
93062000714	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
93062000715	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
93062000716	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
93062000717	putative NAD(P) binding site [chemical binding]; other site
93062000718	catalytic Zn binding site [ion binding]; other site
93062000719	structural Zn binding site [ion binding]; other site
93062000720	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
93062000721	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
93062000722	putative NAD(P) binding site [chemical binding]; other site
93062000723	catalytic Zn binding site [ion binding]; other site
93062000724	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
93062000725	substrate binding site; other site
93062000726	dimer interface; other site
93062000727	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
93062000728	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
93062000729	putative NAD(P) binding site [chemical binding]; other site
93062000730	putative catalytic Zn binding site [ion binding]; other site
93062000731	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
93062000732	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
93062000733	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
93062000734	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
93062000735	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
93062000736	substrate binding site; other site
93062000737	dimer interface; other site
93062000738	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
93062000739	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
93062000740	putative NAD(P) binding site [chemical binding]; other site
93062000741	putative catalytic Zn binding site [ion binding]; other site
93062000742	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
93062000743	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
93062000744	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
93062000745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
93062000746	active site
93062000747	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
93062000748	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
93062000749	Hemerythrin-like domain; Region: Hr-like; cd12108
93062000750	Fe binding site [ion binding]; other site
93062000751	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
93062000752	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
93062000753	Histidine kinase; Region: His_kinase; pfam06580
93062000754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062000755	Mg2+ binding site [ion binding]; other site
93062000756	G-X-G motif; other site
93062000757	two-component response regulator; Provisional; Region: PRK14084
93062000758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062000759	active site
93062000760	phosphorylation site [posttranslational modification]
93062000761	intermolecular recognition site; other site
93062000762	dimerization interface [polypeptide binding]; other site
93062000763	LytTr DNA-binding domain; Region: LytTR; pfam04397
93062000764	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
93062000765	antiholin-like protein LrgB; Provisional; Region: PRK04288
93062000766	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
93062000767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062000768	DNA-binding site [nucleotide binding]; DNA binding site
93062000769	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
93062000770	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
93062000771	active site turn [active]
93062000772	phosphorylation site [posttranslational modification]
93062000773	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
93062000774	HPr interaction site; other site
93062000775	glycerol kinase (GK) interaction site [polypeptide binding]; other site
93062000776	active site
93062000777	phosphorylation site [posttranslational modification]
93062000778	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
93062000779	beta-galactosidase; Region: BGL; TIGR03356
93062000780	Methyltransferase domain; Region: Methyltransf_31; pfam13847
93062000781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062000782	S-adenosylmethionine binding site [chemical binding]; other site
93062000783	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
93062000784	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
93062000785	substrate binding site [chemical binding]; other site
93062000786	dimer interface [polypeptide binding]; other site
93062000787	ATP binding site [chemical binding]; other site
93062000788	D-ribose pyranase; Provisional; Region: PRK11797
93062000789	Sugar transport protein; Region: Sugar_transport; pfam06800
93062000790	Transcriptional regulators [Transcription]; Region: PurR; COG1609
93062000791	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
93062000792	DNA binding site [nucleotide binding]
93062000793	domain linker motif; other site
93062000794	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
93062000795	dimerization interface [polypeptide binding]; other site
93062000796	ligand binding site [chemical binding]; other site
93062000797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062000799	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
93062000800	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
93062000801	active site
93062000802	Surface antigen [General function prediction only]; Region: COG3942
93062000803	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
93062000804	Peptidase family M23; Region: Peptidase_M23; pfam01551
93062000805	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
93062000806	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
93062000807	Walker A/P-loop; other site
93062000808	ATP binding site [chemical binding]; other site
93062000809	Q-loop/lid; other site
93062000810	ABC transporter signature motif; other site
93062000811	Walker B; other site
93062000812	D-loop; other site
93062000813	H-loop/switch region; other site
93062000814	Surface antigen [General function prediction only]; Region: COG3942
93062000815	CHAP domain; Region: CHAP; pfam05257
93062000816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
93062000817	Predicted membrane protein [Function unknown]; Region: COG1511
93062000818	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
93062000819	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
93062000820	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
93062000821	Uncharacterized small protein [Function unknown]; Region: COG5417
93062000822	Predicted membrane protein [Function unknown]; Region: COG4499
93062000823	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
93062000824	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
93062000825	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
93062000826	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
93062000827	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
93062000828	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
93062000829	Uncharacterized conserved protein [Function unknown]; Region: COG5444
93062000830	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
93062000831	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000832	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000833	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000834	conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741
93062000835	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000836	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000837	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000838	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000839	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000840	Protein of unknown function, DUF600; Region: DUF600; cl04640
93062000841	conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741
93062000842	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
93062000843	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
93062000844	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
93062000845	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
93062000846	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
93062000847	FtsX-like permease family; Region: FtsX; pfam02687
93062000848	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
93062000849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
93062000850	Walker A/P-loop; other site
93062000851	ATP binding site [chemical binding]; other site
93062000852	Q-loop/lid; other site
93062000853	ABC transporter signature motif; other site
93062000854	Walker B; other site
93062000855	D-loop; other site
93062000856	H-loop/switch region; other site
93062000857	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
93062000858	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
93062000859	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062000860	non-specific DNA binding site [nucleotide binding]; other site
93062000861	salt bridge; other site
93062000862	sequence-specific DNA binding site [nucleotide binding]; other site
93062000863	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
93062000864	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
93062000865	substrate binding site [chemical binding]; other site
93062000866	ATP binding site [chemical binding]; other site
93062000867	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
93062000868	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
93062000869	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
93062000870	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
93062000871	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
93062000872	putative transporter; Provisional; Region: PRK10484
93062000873	Na binding site [ion binding]; other site
93062000874	N-acetylneuraminate lyase; Provisional; Region: PRK04147
93062000875	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
93062000876	inhibitor site; inhibition site
93062000877	active site
93062000878	dimer interface [polypeptide binding]; other site
93062000879	catalytic residue [active]
93062000880	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
93062000881	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
93062000882	nucleotide binding site [chemical binding]; other site
93062000883	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
93062000884	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
93062000885	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
93062000886	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
93062000887	putative active site [active]
93062000888	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
93062000889	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
93062000890	putative active site cavity [active]
93062000891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
93062000892	Nucleoside recognition; Region: Gate; pfam07670
93062000893	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
93062000894	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
93062000895	PGAP1-like protein; Region: PGAP1; pfam07819
93062000896	Bacteriophage L54a is a temperate phage originally carried as a prophage in Staphylococcus aureus PS54 [PMID:4116059]. It disrupts the Lipase precursor (ORF02798/ORF02874); SA_PHAGE01
93062000897	attL/R core region
93062000898	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
93062000899	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
93062000900	Int/Topo IB signature motif; other site
93062000901	PemK-like protein; Region: PemK; pfam02452
93062000902	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062000903	non-specific DNA binding site [nucleotide binding]; other site
93062000904	salt bridge; other site
93062000905	sequence-specific DNA binding site [nucleotide binding]; other site
93062000906	Predicted transcriptional regulator [Transcription]; Region: COG2932
93062000907	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
93062000908	Catalytic site [active]
93062000909	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062000910	non-specific DNA binding site [nucleotide binding]; other site
93062000911	salt bridge; other site
93062000912	sequence-specific DNA binding site [nucleotide binding]; other site
93062000913	Prophage antirepressor [Transcription]; Region: COG3617
93062000914	BRO family, N-terminal domain; Region: Bro-N; smart01040
93062000915	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
93062000916	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
93062000917	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
93062000918	Homeodomain-like domain; Region: HTH_23; pfam13384
93062000919	Protein of unknown function (DUF1270); Region: DUF1270; pfam06900
93062000920	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
93062000921	Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656
93062000922	Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
93062000923	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
93062000924	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
93062000925	dimer interface [polypeptide binding]; other site
93062000926	ssDNA binding site [nucleotide binding]; other site
93062000927	tetramer (dimer of dimers) interface [polypeptide binding]; other site
93062000928	Protein of unknown function (DUF968); Region: DUF968; pfam06147
93062000929	phage replisome organizer, putative, N-terminal region; Region: phage_rep_org_N; TIGR01714
93062000930	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
93062000931	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
93062000932	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
93062000933	Walker A motif; other site
93062000934	ATP binding site [chemical binding]; other site
93062000935	Walker B motif; other site
93062000936	DNA binding loops [nucleotide binding]
93062000937	Protein of unknown function (DUF3269); Region: DUF3269; pfam11673
93062000938	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
93062000939	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
93062000940	Protein of unknown function (DUF3113); Region: DUF3113; pfam11310
93062000941	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
93062000942	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062000943	non-specific DNA binding site [nucleotide binding]; other site
93062000944	salt bridge; other site
93062000945	sequence-specific DNA binding site [nucleotide binding]; other site
93062000946	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
93062000947	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
93062000948	YopX protein; Region: YopX; pfam09643
93062000949	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
93062000950	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
93062000951	trimer interface [polypeptide binding]; other site
93062000952	active site
93062000953	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
93062000954	Transcriptional activator RinB; Region: RinB; pfam06116
93062000955	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
93062000956	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
93062000957	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
93062000958	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
93062000959	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
93062000960	active site
93062000961	Phage terminase, small subunit; Region: Terminase_4; pfam05119
93062000962	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
93062000963	Phage-related protein [Function unknown]; Region: COG4695; cl01923
93062000964	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
93062000965	Clp protease; Region: CLP_protease; pfam00574
93062000966	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
93062000967	oligomer interface [polypeptide binding]; other site
93062000968	active site residues [active]
93062000969	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
93062000970	Phage capsid family; Region: Phage_capsid; pfam05065
93062000971	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
93062000972	oligomerization interface [polypeptide binding]; other site
93062000973	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
93062000974	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
93062000975	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
93062000976	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
93062000977	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
93062000978	linker region; other site
93062000979	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
93062000980	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
93062000981	dimer interface [polypeptide binding]; other site
93062000982	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
93062000983	Peptidase family M23; Region: Peptidase_M23; pfam01551
93062000984	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
93062000985	N-acetyl-D-glucosamine binding site [chemical binding]; other site
93062000986	catalytic residue [active]
93062000987	Phage tail protein; Region: Sipho_tail; pfam05709
93062000988	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
93062000989	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
93062000990	hypothetical protein; Provisional; Region: PRK05926
93062000991	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
93062000992	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
93062000993	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
93062000994	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
93062000995	holin, SPP1 family; Region: holin_SPP1; TIGR01592
93062000996	CHAP domain; Region: CHAP; pfam05257
93062000997	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
93062000998	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
93062000999	active site
93062001000	metal binding site [ion binding]; metal-binding site
93062001001	Bacterial SH3 domain; Region: SH3_5; pfam08460
93062001002	attL/R core region
93062001003	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
93062001004	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
93062001005	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
93062001006	putative active site [active]
93062001007	putative FMN binding site [chemical binding]; other site
93062001008	putative substrate binding site [chemical binding]; other site
93062001009	putative catalytic residue [active]
93062001010	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
93062001011	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
93062001012	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
93062001013	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
93062001014	lipoyl attachment site [posttranslational modification]; other site
93062001015	Replication protein C N-terminal domain; Region: RP-C; pfam03428
93062001016	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
93062001017	putative ADP-ribose binding site [chemical binding]; other site
93062001018	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
93062001019	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
93062001020	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
93062001021	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
93062001022	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
93062001023	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
93062001024	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
93062001025	NADP binding site [chemical binding]; other site
93062001026	putative substrate binding site [chemical binding]; other site
93062001027	active site
93062001028	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
93062001029	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
93062001030	active site
93062001031	P-loop; other site
93062001032	phosphorylation site [posttranslational modification]
93062001033	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062001034	active site
93062001035	phosphorylation site [posttranslational modification]
93062001036	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
93062001037	HTH domain; Region: HTH_11; pfam08279
93062001038	HTH domain; Region: HTH_11; pfam08279
93062001039	PRD domain; Region: PRD; pfam00874
93062001040	PRD domain; Region: PRD; pfam00874
93062001041	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
93062001042	active site
93062001043	P-loop; other site
93062001044	phosphorylation site [posttranslational modification]
93062001045	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062001046	active site
93062001047	phosphorylation site [posttranslational modification]
93062001048	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062001049	MarR family; Region: MarR_2; pfam12802
93062001050	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
93062001051	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
93062001052	MepB protein; Region: MepB; cl01985
93062001053	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
93062001054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062001055	putative substrate translocation pore; other site
93062001056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062001057	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
93062001058	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
93062001059	Zn binding site [ion binding]; other site
93062001060	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
93062001061	Zn binding site [ion binding]; other site
93062001062	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
93062001063	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
93062001064	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
93062001065	Predicted flavoprotein [General function prediction only]; Region: COG0431
93062001066	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
93062001067	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
93062001068	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
93062001069	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
93062001070	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
93062001071	Imelysin; Region: Peptidase_M75; pfam09375
93062001072	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
93062001073	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
93062001074	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
93062001075	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
93062001076	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
93062001077	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
93062001078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062001079	non-specific DNA binding site [nucleotide binding]; other site
93062001080	salt bridge; other site
93062001081	sequence-specific DNA binding site [nucleotide binding]; other site
93062001082	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
93062001083	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
93062001084	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
93062001085	Walker A/P-loop; other site
93062001086	ATP binding site [chemical binding]; other site
93062001087	Q-loop/lid; other site
93062001088	ABC transporter signature motif; other site
93062001089	Walker B; other site
93062001090	D-loop; other site
93062001091	H-loop/switch region; other site
93062001092	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
93062001093	Predicted membrane protein [Function unknown]; Region: COG4292
93062001094	putative acyltransferase; Provisional; Region: PRK05790
93062001095	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
93062001096	dimer interface [polypeptide binding]; other site
93062001097	active site
93062001098	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
93062001099	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
93062001100	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
93062001101	THF binding site; other site
93062001102	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
93062001103	substrate binding site [chemical binding]; other site
93062001104	THF binding site; other site
93062001105	zinc-binding site [ion binding]; other site
93062001106	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
93062001107	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
93062001108	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
93062001109	FAD binding site [chemical binding]; other site
93062001110	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
93062001111	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
93062001112	homodimer interface [polypeptide binding]; other site
93062001113	substrate-cofactor binding pocket; other site
93062001114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062001115	catalytic residue [active]
93062001116	cystathionine gamma-synthase; Reviewed; Region: PRK08247
93062001117	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
93062001118	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062001119	catalytic residue [active]
93062001120	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
93062001121	ParB-like nuclease domain; Region: ParB; smart00470
93062001122	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
93062001123	Mechanosensitive ion channel; Region: MS_channel; pfam00924
93062001124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
93062001125	GTP-binding protein YchF; Reviewed; Region: PRK09601
93062001126	YchF GTPase; Region: YchF; cd01900
93062001127	G1 box; other site
93062001128	GTP/Mg2+ binding site [chemical binding]; other site
93062001129	Switch I region; other site
93062001130	G2 box; other site
93062001131	Switch II region; other site
93062001132	G3 box; other site
93062001133	G4 box; other site
93062001134	G5 box; other site
93062001135	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
93062001136	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
93062001137	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
93062001138	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
93062001139	dimer interface [polypeptide binding]; other site
93062001140	ssDNA binding site [nucleotide binding]; other site
93062001141	tetramer (dimer of dimers) interface [polypeptide binding]; other site
93062001142	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
93062001143	Abi-like protein; Region: Abi_2; pfam07751
93062001144	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
93062001146	Predicted membrane protein [Function unknown]; Region: COG3212
93062001147	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
93062001148	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
93062001149	non-specific DNA binding site [nucleotide binding]; other site
93062001150	salt bridge; other site
93062001151	sequence-specific DNA binding site [nucleotide binding]; other site
93062001152	Predicted membrane protein [Function unknown]; Region: COG2261
93062001153	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
93062001154	catalytic core [active]
93062001155	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
93062001156	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
93062001157	catalytic residue [active]
93062001158	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
93062001159	catalytic residues [active]
93062001160	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
93062001161	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062001162	peroxiredoxin; Region: AhpC; TIGR03137
93062001163	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
93062001164	dimer interface [polypeptide binding]; other site
93062001165	decamer (pentamer of dimers) interface [polypeptide binding]; other site
93062001166	catalytic triad [active]
93062001167	peroxidatic and resolving cysteines [active]
93062001168	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
93062001169	dimer interface [polypeptide binding]; other site
93062001170	FMN binding site [chemical binding]; other site
93062001171	NADPH bind site [chemical binding]; other site
93062001172	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
93062001173	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
93062001174	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062001175	active site
93062001176	xanthine permease; Region: pbuX; TIGR03173
93062001177	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
93062001178	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
93062001179	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
93062001180	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
93062001181	active site
93062001182	GMP synthase; Reviewed; Region: guaA; PRK00074
93062001183	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
93062001184	AMP/PPi binding site [chemical binding]; other site
93062001185	candidate oxyanion hole; other site
93062001186	catalytic triad [active]
93062001187	potential glutamine specificity residues [chemical binding]; other site
93062001188	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
93062001189	ATP Binding subdomain [chemical binding]; other site
93062001190	Ligand Binding sites [chemical binding]; other site
93062001191	Dimerization subdomain; other site
93062001192	PemK-like protein; Region: PemK; pfam02452
93062001193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
93062001194	Transposase; Region: HTH_Tnp_1; cl17663
93062001195	Predicted membrane protein [Function unknown]; Region: COG3759
93062001196	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
93062001197	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
93062001198	NADP binding site [chemical binding]; other site
93062001199	superantigen-like protein; Reviewed; Region: PRK13037
93062001200	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001201	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001202	superantigen-like protein; Reviewed; Region: PRK13041
93062001203	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001204	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001205	superantigen-like protein; Reviewed; Region: PRK13335
93062001206	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001207	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001208	superantigen-like protein; Reviewed; Region: PRK13042
93062001209	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001210	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001211	superantigen-like protein; Reviewed; Region: PRK13345
93062001212	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001213	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001214	superantigen-like protein 5; Reviewed; Region: PRK13035
93062001215	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001216	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001217	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
93062001218	HsdM N-terminal domain; Region: HsdM_N; pfam12161
93062001219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062001220	S-adenosylmethionine binding site [chemical binding]; other site
93062001221	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
93062001222	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
93062001223	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
93062001224	superantigen-like protein; Reviewed; Region: PRK13036
93062001225	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
93062001226	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062001227	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062001228	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062001229	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062001230	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062001231	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062001232	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062001233	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
93062001234	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
93062001235	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
93062001236	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
93062001237	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
93062001238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
93062001239	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
93062001240	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
93062001241	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
93062001242	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
93062001243	active site
93062001244	Esterase/lipase [General function prediction only]; Region: COG1647
93062001245	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
93062001246	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
93062001247	Na2 binding site [ion binding]; other site
93062001248	putative substrate binding site 1 [chemical binding]; other site
93062001249	Na binding site 1 [ion binding]; other site
93062001250	putative substrate binding site 2 [chemical binding]; other site
93062001251	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
93062001252	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
93062001253	dimer interface [polypeptide binding]; other site
93062001254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062001255	catalytic residue [active]
93062001256	cystathionine beta-lyase; Provisional; Region: PRK07671
93062001257	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
93062001258	homodimer interface [polypeptide binding]; other site
93062001259	substrate-cofactor binding pocket; other site
93062001260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062001261	catalytic residue [active]
93062001262	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
93062001263	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
93062001264	Walker A/P-loop; other site
93062001265	ATP binding site [chemical binding]; other site
93062001266	Q-loop/lid; other site
93062001267	ABC transporter signature motif; other site
93062001268	Walker B; other site
93062001269	D-loop; other site
93062001270	H-loop/switch region; other site
93062001271	NIL domain; Region: NIL; pfam09383
93062001272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062001273	dimer interface [polypeptide binding]; other site
93062001274	conserved gate region; other site
93062001275	ABC-ATPase subunit interface; other site
93062001276	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
93062001277	LysM domain; Region: LysM; pfam01476
93062001278	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062001279	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062001280	Surface antigen [General function prediction only]; Region: COG3942
93062001281	CHAP domain; Region: CHAP; pfam05257
93062001282	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
93062001283	nudix motif; other site
93062001284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062001285	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
93062001286	Coenzyme A binding pocket [chemical binding]; other site
93062001287	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
93062001288	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
93062001289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062001290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062001291	LysR substrate binding domain; Region: LysR_substrate; pfam03466
93062001292	dimerization interface [polypeptide binding]; other site
93062001293	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
93062001294	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
93062001295	active site
93062001296	dimer interface [polypeptide binding]; other site
93062001297	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
93062001298	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
93062001299	active site
93062001300	FMN binding site [chemical binding]; other site
93062001301	substrate binding site [chemical binding]; other site
93062001302	3Fe-4S cluster binding site [ion binding]; other site
93062001303	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
93062001304	domain interface; other site
93062001305	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
93062001306	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
93062001307	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062001308	active site turn [active]
93062001309	phosphorylation site [posttranslational modification]
93062001310	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062001311	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
93062001312	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
93062001313	Ca binding site [ion binding]; other site
93062001314	active site
93062001315	catalytic site [active]
93062001316	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
93062001317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062001318	DNA-binding site [nucleotide binding]; DNA binding site
93062001319	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
93062001320	UTRA domain; Region: UTRA; pfam07702
93062001321	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
93062001322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062001323	Coenzyme A binding pocket [chemical binding]; other site
93062001324	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
93062001325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062001326	Walker A motif; other site
93062001327	ATP binding site [chemical binding]; other site
93062001328	Walker B motif; other site
93062001329	arginine finger; other site
93062001330	hypothetical protein; Validated; Region: PRK00153
93062001331	recombination protein RecR; Reviewed; Region: recR; PRK00076
93062001332	RecR protein; Region: RecR; pfam02132
93062001333	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
93062001334	putative active site [active]
93062001335	putative metal-binding site [ion binding]; other site
93062001336	tetramer interface [polypeptide binding]; other site
93062001337	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
93062001338	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
93062001339	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062001340	catalytic residue [active]
93062001341	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
93062001342	thymidylate kinase; Validated; Region: tmk; PRK00698
93062001343	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
93062001344	TMP-binding site; other site
93062001345	ATP-binding site [chemical binding]; other site
93062001346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
93062001347	DNA polymerase III subunit delta'; Validated; Region: PRK08058
93062001348	DNA polymerase III subunit delta'; Validated; Region: PRK08485
93062001349	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
93062001350	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
93062001351	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
93062001352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062001353	S-adenosylmethionine binding site [chemical binding]; other site
93062001354	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
93062001355	GIY-YIG motif/motif A; other site
93062001356	putative active site [active]
93062001357	putative metal binding site [ion binding]; other site
93062001358	Predicted methyltransferases [General function prediction only]; Region: COG0313
93062001359	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
93062001360	putative SAM binding site [chemical binding]; other site
93062001361	putative homodimer interface [polypeptide binding]; other site
93062001362	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
93062001363	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
93062001364	active site
93062001365	HIGH motif; other site
93062001366	KMSKS motif; other site
93062001367	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
93062001368	tRNA binding surface [nucleotide binding]; other site
93062001369	anticodon binding site; other site
93062001370	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
93062001371	dimer interface [polypeptide binding]; other site
93062001372	putative tRNA-binding site [nucleotide binding]; other site
93062001373	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
93062001374	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
93062001375	active site
93062001376	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
93062001377	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
93062001378	putative active site [active]
93062001379	putative metal binding site [ion binding]; other site
93062001380	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
93062001381	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
93062001382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062001383	S-adenosylmethionine binding site [chemical binding]; other site
93062001384	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
93062001385	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
93062001386	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
93062001387	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
93062001388	pur operon repressor; Provisional; Region: PRK09213
93062001389	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
93062001390	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062001391	active site
93062001392	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
93062001393	homotrimer interaction site [polypeptide binding]; other site
93062001394	putative active site [active]
93062001395	regulatory protein SpoVG; Reviewed; Region: PRK13259
93062001396	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
93062001397	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
93062001398	Substrate binding site; other site
93062001399	Mg++ binding site; other site
93062001400	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
93062001401	active site
93062001402	substrate binding site [chemical binding]; other site
93062001403	CoA binding site [chemical binding]; other site
93062001404	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
93062001405	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
93062001406	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062001407	active site
93062001408	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
93062001409	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
93062001410	5S rRNA interface [nucleotide binding]; other site
93062001411	CTC domain interface [polypeptide binding]; other site
93062001412	L16 interface [polypeptide binding]; other site
93062001413	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
93062001414	putative active site [active]
93062001415	catalytic residue [active]
93062001416	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
93062001417	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
93062001418	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062001419	ATP binding site [chemical binding]; other site
93062001420	putative Mg++ binding site [ion binding]; other site
93062001421	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062001422	nucleotide binding region [chemical binding]; other site
93062001423	ATP-binding site [chemical binding]; other site
93062001424	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
93062001425	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
93062001426	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
93062001427	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
93062001428	putative SAM binding site [chemical binding]; other site
93062001429	putative homodimer interface [polypeptide binding]; other site
93062001430	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
93062001431	homodimer interface [polypeptide binding]; other site
93062001432	metal binding site [ion binding]; metal-binding site
93062001433	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062001434	RNA binding surface [nucleotide binding]; other site
93062001435	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
93062001436	Septum formation initiator; Region: DivIC; pfam04977
93062001437	hypothetical protein; Provisional; Region: PRK08582
93062001438	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
93062001439	RNA binding site [nucleotide binding]; other site
93062001440	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
93062001441	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
93062001442	Ligand Binding Site [chemical binding]; other site
93062001443	TilS substrate C-terminal domain; Region: TilS_C; smart00977
93062001444	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
93062001445	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062001446	active site
93062001447	FtsH Extracellular; Region: FtsH_ext; pfam06480
93062001448	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
93062001449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062001450	Walker A motif; other site
93062001451	ATP binding site [chemical binding]; other site
93062001452	Walker B motif; other site
93062001453	arginine finger; other site
93062001454	Peptidase family M41; Region: Peptidase_M41; pfam01434
93062001455	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
93062001456	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
93062001457	dimerization interface [polypeptide binding]; other site
93062001458	domain crossover interface; other site
93062001459	redox-dependent activation switch; other site
93062001460	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
93062001461	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
93062001462	dimer interface [polypeptide binding]; other site
93062001463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062001464	catalytic residue [active]
93062001465	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
93062001466	dihydropteroate synthase; Region: DHPS; TIGR01496
93062001467	substrate binding pocket [chemical binding]; other site
93062001468	dimer interface [polypeptide binding]; other site
93062001469	inhibitor binding site; inhibition site
93062001470	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
93062001471	homooctamer interface [polypeptide binding]; other site
93062001472	active site
93062001473	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
93062001474	catalytic center binding site [active]
93062001475	ATP binding site [chemical binding]; other site
93062001476	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
93062001477	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
93062001478	dimer interface [polypeptide binding]; other site
93062001479	putative anticodon binding site; other site
93062001480	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
93062001481	motif 1; other site
93062001482	active site
93062001483	motif 2; other site
93062001484	motif 3; other site
93062001485	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
93062001486	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062001487	DNA-binding site [nucleotide binding]; DNA binding site
93062001488	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062001489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062001490	homodimer interface [polypeptide binding]; other site
93062001491	catalytic residue [active]
93062001492	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
93062001493	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
93062001494	active site
93062001495	multimer interface [polypeptide binding]; other site
93062001496	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
93062001497	predicted active site [active]
93062001498	catalytic triad [active]
93062001499	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
93062001500	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
93062001501	Nucleoside recognition; Region: Gate; pfam07670
93062001502	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
93062001503	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
93062001504	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
93062001505	UvrB/uvrC motif; Region: UVR; pfam02151
93062001506	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
93062001507	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
93062001508	ADP binding site [chemical binding]; other site
93062001509	phosphagen binding site; other site
93062001510	substrate specificity loop; other site
93062001511	DNA repair protein RadA; Provisional; Region: PRK11823
93062001512	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
93062001513	Walker A motif/ATP binding site; other site
93062001514	ATP binding site [chemical binding]; other site
93062001515	Walker B motif; other site
93062001516	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
93062001517	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
93062001518	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
93062001519	putative active site [active]
93062001520	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
93062001521	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
93062001522	active site
93062001523	HIGH motif; other site
93062001524	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
93062001525	active site
93062001526	KMSKS motif; other site
93062001527	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
93062001528	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
93062001529	trimer interface [polypeptide binding]; other site
93062001530	active site
93062001531	substrate binding site [chemical binding]; other site
93062001532	CoA binding site [chemical binding]; other site
93062001533	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
93062001534	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
93062001535	active site
93062001536	HIGH motif; other site
93062001537	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
93062001538	KMSKS motif; other site
93062001539	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
93062001540	tRNA binding surface [nucleotide binding]; other site
93062001541	anticodon binding site; other site
93062001542	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
93062001543	active site
93062001544	dimerization interface [polypeptide binding]; other site
93062001545	metal binding site [ion binding]; metal-binding site
93062001546	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
93062001547	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
93062001548	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
93062001549	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
93062001550	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
93062001551	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
93062001552	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
93062001553	DNA binding residues [nucleotide binding]
93062001554	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
93062001555	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
93062001556	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
93062001557	putative homodimer interface [polypeptide binding]; other site
93062001558	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
93062001559	heterodimer interface [polypeptide binding]; other site
93062001560	homodimer interface [polypeptide binding]; other site
93062001561	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
93062001562	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
93062001563	23S rRNA interface [nucleotide binding]; other site
93062001564	L7/L12 interface [polypeptide binding]; other site
93062001565	putative thiostrepton binding site; other site
93062001566	L25 interface [polypeptide binding]; other site
93062001567	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
93062001568	mRNA/rRNA interface [nucleotide binding]; other site
93062001569	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
93062001570	23S rRNA interface [nucleotide binding]; other site
93062001571	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
93062001572	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
93062001573	peripheral dimer interface [polypeptide binding]; other site
93062001574	core dimer interface [polypeptide binding]; other site
93062001575	L10 interface [polypeptide binding]; other site
93062001576	L11 interface [polypeptide binding]; other site
93062001577	putative EF-Tu interaction site [polypeptide binding]; other site
93062001578	putative EF-G interaction site [polypeptide binding]; other site
93062001579	Methyltransferase domain; Region: Methyltransf_31; pfam13847
93062001580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062001581	S-adenosylmethionine binding site [chemical binding]; other site
93062001582	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
93062001583	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
93062001584	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
93062001585	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
93062001586	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
93062001587	RPB10 interaction site [polypeptide binding]; other site
93062001588	RPB1 interaction site [polypeptide binding]; other site
93062001589	RPB11 interaction site [polypeptide binding]; other site
93062001590	RPB3 interaction site [polypeptide binding]; other site
93062001591	RPB12 interaction site [polypeptide binding]; other site
93062001592	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
93062001593	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
93062001594	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
93062001595	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
93062001596	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
93062001597	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
93062001598	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
93062001599	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
93062001600	G-loop; other site
93062001601	DNA binding site [nucleotide binding]
93062001602	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
93062001603	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
93062001604	S17 interaction site [polypeptide binding]; other site
93062001605	S8 interaction site; other site
93062001606	16S rRNA interaction site [nucleotide binding]; other site
93062001607	streptomycin interaction site [chemical binding]; other site
93062001608	23S rRNA interaction site [nucleotide binding]; other site
93062001609	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
93062001610	30S ribosomal protein S7; Validated; Region: PRK05302
93062001611	elongation factor G; Reviewed; Region: PRK00007
93062001612	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
93062001613	G1 box; other site
93062001614	putative GEF interaction site [polypeptide binding]; other site
93062001615	GTP/Mg2+ binding site [chemical binding]; other site
93062001616	Switch I region; other site
93062001617	G2 box; other site
93062001618	G3 box; other site
93062001619	Switch II region; other site
93062001620	G4 box; other site
93062001621	G5 box; other site
93062001622	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
93062001623	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
93062001624	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
93062001625	elongation factor Tu; Reviewed; Region: PRK00049
93062001626	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
93062001627	G1 box; other site
93062001628	GEF interaction site [polypeptide binding]; other site
93062001629	GTP/Mg2+ binding site [chemical binding]; other site
93062001630	Switch I region; other site
93062001631	G2 box; other site
93062001632	G3 box; other site
93062001633	Switch II region; other site
93062001634	G4 box; other site
93062001635	G5 box; other site
93062001636	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
93062001637	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
93062001638	Antibiotic Binding Site [chemical binding]; other site
93062001639	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
93062001640	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
93062001641	metal binding site [ion binding]; metal-binding site
93062001642	dimer interface [polypeptide binding]; other site
93062001643	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
93062001644	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
93062001645	substrate-cofactor binding pocket; other site
93062001646	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062001647	catalytic residue [active]
93062001648	chaperone protein HchA; Provisional; Region: PRK04155
93062001649	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
93062001650	dimer interface [polypeptide binding]; other site
93062001651	metal binding site [ion binding]; metal-binding site
93062001652	potential oxyanion hole; other site
93062001653	potential catalytic triad [active]
93062001654	conserved cys residue [active]
93062001655	ribulokinase; Provisional; Region: PRK04123
93062001656	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
93062001657	N- and C-terminal domain interface [polypeptide binding]; other site
93062001658	active site
93062001659	MgATP binding site [chemical binding]; other site
93062001660	catalytic site [active]
93062001661	metal binding site [ion binding]; metal-binding site
93062001662	carbohydrate binding site [chemical binding]; other site
93062001663	homodimer interface [polypeptide binding]; other site
93062001664	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
93062001665	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062001666	NAD(P) binding site [chemical binding]; other site
93062001667	active site
93062001668	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
93062001669	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
93062001670	homodimer interface [polypeptide binding]; other site
93062001671	substrate-cofactor binding pocket; other site
93062001672	catalytic residue [active]
93062001673	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
93062001674	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062001675	motif II; other site
93062001676	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
93062001677	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
93062001678	Substrate-binding site [chemical binding]; other site
93062001679	Substrate specificity [chemical binding]; other site
93062001680	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
93062001681	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
93062001682	Substrate-binding site [chemical binding]; other site
93062001683	Substrate specificity [chemical binding]; other site
93062001684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062001685	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
93062001686	active site
93062001687	motif I; other site
93062001688	motif II; other site
93062001689	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062001690	Predicted flavoprotein [General function prediction only]; Region: COG0431
93062001691	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
93062001692	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062001693	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062001694	Cna protein B-type domain; Region: Cna_B; pfam05738
93062001695	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
93062001696	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062001697	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062001698	Cna protein B-type domain; Region: Cna_B; pfam05738
93062001699	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
93062001700	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
93062001701	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
93062001702	Cna protein B-type domain; Region: Cna_B; pfam05738
93062001703	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062001704	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062001705	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
93062001706	Cna protein B-type domain; Region: Cna_B; pfam05738
93062001707	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
93062001708	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
93062001709	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
93062001710	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062001711	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
93062001712	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
93062001713	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062001714	putative GTP cyclohydrolase; Provisional; Region: PRK13674
93062001715	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
93062001716	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
93062001717	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
93062001718	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
93062001719	active site
93062001720	trimer interface [polypeptide binding]; other site
93062001721	allosteric site; other site
93062001722	active site lid [active]
93062001723	hexamer (dimer of trimers) interface [polypeptide binding]; other site
93062001724	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
93062001725	active site
93062001726	dimer interface [polypeptide binding]; other site
93062001727	magnesium binding site [ion binding]; other site
93062001728	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
93062001729	tetramer interface [polypeptide binding]; other site
93062001730	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
93062001731	active site
93062001732	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
93062001733	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062001734	motif II; other site
93062001735	proline/glycine betaine transporter; Provisional; Region: PRK10642
93062001736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062001737	putative substrate translocation pore; other site
93062001738	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
93062001739	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
93062001740	acyl-activating enzyme (AAE) consensus motif; other site
93062001741	AMP binding site [chemical binding]; other site
93062001742	active site
93062001743	CoA binding site [chemical binding]; other site
93062001744	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
93062001745	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
93062001746	dimer interface [polypeptide binding]; other site
93062001747	active site
93062001748	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
93062001749	dimer interface [polypeptide binding]; other site
93062001750	substrate binding site [chemical binding]; other site
93062001751	ATP binding site [chemical binding]; other site
93062001752	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
93062001753	ligand binding site [chemical binding]; other site
93062001754	active site
93062001755	UGI interface [polypeptide binding]; other site
93062001756	catalytic site [active]
93062001757	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
93062001758	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
93062001759	Uncharacterized conserved protein [Function unknown]; Region: COG3610
93062001760	Uncharacterized conserved protein [Function unknown]; Region: COG2966
93062001761	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
93062001762	putative heme peroxidase; Provisional; Region: PRK12276
93062001763	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
93062001764	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
93062001765	mevalonate kinase; Region: mevalon_kin; TIGR00549
93062001766	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
93062001767	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
93062001768	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
93062001769	diphosphomevalonate decarboxylase; Region: PLN02407
93062001770	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
93062001771	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
93062001772	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
93062001773	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
93062001774	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
93062001775	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
93062001776	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062001777	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
93062001778	Predicted transcriptional regulator [Transcription]; Region: COG1959
93062001779	Transcriptional regulator; Region: Rrf2; pfam02082
93062001780	LXG domain of WXG superfamily; Region: LXG; pfam04740
93062001781	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001782	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001783	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001784	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001785	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001786	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001787	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001788	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001789	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001790	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001791	Protein of unknown function (DUF443); Region: DUF443; pfam04276
93062001792	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
93062001793	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
93062001794	active site
93062001795	catalytic tetrad [active]
93062001796	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
93062001797	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
93062001798	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
93062001799	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
93062001800	Zn2+ binding site [ion binding]; other site
93062001801	Mg2+ binding site [ion binding]; other site
93062001802	YwhD family; Region: YwhD; pfam08741
93062001803	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
93062001804	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
93062001805	NAD binding site [chemical binding]; other site
93062001806	substrate binding site [chemical binding]; other site
93062001807	catalytic Zn binding site [ion binding]; other site
93062001808	tetramer interface [polypeptide binding]; other site
93062001809	structural Zn binding site [ion binding]; other site
93062001810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
93062001811	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
93062001812	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
93062001813	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
93062001814	active site
93062001815	HIGH motif; other site
93062001816	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
93062001817	KMSK motif region; other site
93062001818	tRNA binding surface [nucleotide binding]; other site
93062001819	DALR anticodon binding domain; Region: DALR_1; smart00836
93062001820	anticodon binding site; other site
93062001821	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
93062001822	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
93062001823	minor groove reading motif; other site
93062001824	helix-hairpin-helix signature motif; other site
93062001825	substrate binding pocket [chemical binding]; other site
93062001826	active site
93062001827	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
93062001828	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
93062001829	putative binding site residues; other site
93062001830	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062001831	ABC-ATPase subunit  interface; other site
93062001832	dimer interface [polypeptide binding]; other site
93062001833	putative PBP binding regions; other site
93062001834	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
93062001835	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062001836	motif II; other site
93062001837	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
93062001838	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
93062001839	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
93062001840	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
93062001841	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062001842	Transcriptional regulators [Transcription]; Region: MarR; COG1846
93062001843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
93062001844	Protein of unknown function, DUF606; Region: DUF606; pfam04657
93062001845	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
93062001846	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
93062001847	active site
93062001848	DNA binding site [nucleotide binding]
93062001849	Int/Topo IB signature motif; other site
93062001850	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
93062001851	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
93062001852	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
93062001853	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
93062001854	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
93062001855	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
93062001856	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
93062001857	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
93062001858	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
93062001859	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
93062001860	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
93062001861	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
93062001862	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
93062001863	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
93062001864	metal binding site [ion binding]; metal-binding site
93062001865	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
93062001866	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062001867	ABC-ATPase subunit  interface; other site
93062001868	dimer interface [polypeptide binding]; other site
93062001869	putative PBP binding regions; other site
93062001870	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
93062001871	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
93062001872	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
93062001873	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
93062001874	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
93062001875	FeoA domain; Region: FeoA; pfam04023
93062001876	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
93062001877	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
93062001878	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
93062001879	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
93062001880	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
93062001881	Walker A/P-loop; other site
93062001882	ATP binding site [chemical binding]; other site
93062001883	Q-loop/lid; other site
93062001884	ABC transporter signature motif; other site
93062001885	Walker B; other site
93062001886	D-loop; other site
93062001887	H-loop/switch region; other site
93062001888	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
93062001889	ABC-2 type transporter; Region: ABC2_membrane; cl17235
93062001890	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
93062001891	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
93062001892	active site
93062001893	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
93062001894	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
93062001895	active site
93062001896	nucleotide binding site [chemical binding]; other site
93062001897	HIGH motif; other site
93062001898	KMSKS motif; other site
93062001899	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
93062001900	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
93062001901	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
93062001902	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
93062001903	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
93062001904	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062001905	Walker A/P-loop; other site
93062001906	ATP binding site [chemical binding]; other site
93062001907	Q-loop/lid; other site
93062001908	ABC transporter signature motif; other site
93062001909	Walker B; other site
93062001910	D-loop; other site
93062001911	H-loop/switch region; other site
93062001912	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
93062001913	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
93062001914	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
93062001915	Uncharacterized conserved protein [Function unknown]; Region: COG1284
93062001916	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
93062001917	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
93062001918	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
93062001919	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
93062001920	Walker A/P-loop; other site
93062001921	ATP binding site [chemical binding]; other site
93062001922	Q-loop/lid; other site
93062001923	ABC transporter signature motif; other site
93062001924	Walker B; other site
93062001925	D-loop; other site
93062001926	H-loop/switch region; other site
93062001927	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
93062001928	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062001929	ABC-ATPase subunit  interface; other site
93062001930	dimer interface [polypeptide binding]; other site
93062001931	putative PBP binding regions; other site
93062001932	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
93062001933	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062001934	ABC-ATPase subunit  interface; other site
93062001935	dimer interface [polypeptide binding]; other site
93062001936	putative PBP binding regions; other site
93062001937	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
93062001938	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
93062001939	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
93062001940	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
93062001941	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
93062001942	Uncharacterized membrane protein [Function unknown]; Region: COG3949
93062001943	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
93062001944	Na binding site [ion binding]; other site
93062001945	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
93062001946	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
93062001947	substrate binding pocket [chemical binding]; other site
93062001948	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
93062001949	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
93062001950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062001951	Coenzyme A binding pocket [chemical binding]; other site
93062001952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
93062001953	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
93062001954	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062001955	NAD(P) binding site [chemical binding]; other site
93062001956	active site
93062001957	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062001958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062001959	active site
93062001960	phosphorylation site [posttranslational modification]
93062001961	intermolecular recognition site; other site
93062001962	dimerization interface [polypeptide binding]; other site
93062001963	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062001964	DNA binding site [nucleotide binding]
93062001965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
93062001966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
93062001967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062001968	ATP binding site [chemical binding]; other site
93062001969	Mg2+ binding site [ion binding]; other site
93062001970	G-X-G motif; other site
93062001971	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
93062001972	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
93062001973	Walker A/P-loop; other site
93062001974	ATP binding site [chemical binding]; other site
93062001975	Q-loop/lid; other site
93062001976	ABC transporter signature motif; other site
93062001977	Walker B; other site
93062001978	D-loop; other site
93062001979	H-loop/switch region; other site
93062001980	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
93062001981	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
93062001982	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062001983	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
93062001984	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062001985	Surface antigen [General function prediction only]; Region: COG3942
93062001986	CHAP domain; Region: CHAP; pfam05257
93062001987	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
93062001988	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
93062001989	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
93062001990	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062001991	hypothetical protein; Provisional; Region: PRK12378
93062001992	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
93062001993	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
93062001994	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062001995	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062001996	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
93062001997	dimerization interface [polypeptide binding]; other site
93062001998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062001999	sugar efflux transporter; Region: 2A0120; TIGR00899
93062002000	putative substrate translocation pore; other site
93062002001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
93062002002	Serine incorporator (Serinc); Region: Serinc; pfam03348
93062002003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062002004	Coenzyme A binding pocket [chemical binding]; other site
93062002005	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
93062002006	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
93062002007	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
93062002008	hypothetical protein; Validated; Region: PRK00124
93062002009	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
93062002010	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
93062002011	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
93062002012	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
93062002013	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
93062002014	Walker A/P-loop; other site
93062002015	ATP binding site [chemical binding]; other site
93062002016	Q-loop/lid; other site
93062002017	ABC transporter signature motif; other site
93062002018	Walker B; other site
93062002019	D-loop; other site
93062002020	H-loop/switch region; other site
93062002021	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
93062002022	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
93062002023	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
93062002024	Walker A/P-loop; other site
93062002025	ATP binding site [chemical binding]; other site
93062002026	Q-loop/lid; other site
93062002027	ABC transporter signature motif; other site
93062002028	Walker B; other site
93062002029	D-loop; other site
93062002030	H-loop/switch region; other site
93062002031	Transcriptional regulators [Transcription]; Region: MarR; COG1846
93062002032	MarR family; Region: MarR; pfam01047
93062002033	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
93062002034	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
93062002035	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
93062002036	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
93062002037	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
93062002038	active site
93062002039	catalytic tetrad [active]
93062002040	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
93062002041	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
93062002042	transmembrane helices; other site
93062002043	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
93062002044	DNA photolyase; Region: DNA_photolyase; pfam00875
93062002045	Predicted membrane protein [Function unknown]; Region: COG4330
93062002046	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
93062002047	trimer interface [polypeptide binding]; other site
93062002048	putative Zn binding site [ion binding]; other site
93062002049	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
93062002050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062002051	putative substrate translocation pore; other site
93062002052	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
93062002053	putative deacylase active site [active]
93062002054	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
93062002055	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
93062002056	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
93062002057	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
93062002058	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
93062002059	putative substrate binding site [chemical binding]; other site
93062002060	putative ATP binding site [chemical binding]; other site
93062002061	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
93062002062	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
93062002063	active site
93062002064	dimer interface [polypeptide binding]; other site
93062002065	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
93062002066	Domain of unknown function DUF21; Region: DUF21; pfam01595
93062002067	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
93062002068	Transporter associated domain; Region: CorC_HlyC; pfam03471
93062002069	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
93062002070	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
93062002071	active site
93062002072	catalytic tetrad [active]
93062002073	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
93062002074	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
93062002075	Ligand binding site; other site
93062002076	Putative Catalytic site; other site
93062002077	DXD motif; other site
93062002078	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
93062002079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062002080	dimer interface [polypeptide binding]; other site
93062002081	phosphorylation site [posttranslational modification]
93062002082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062002083	ATP binding site [chemical binding]; other site
93062002084	Mg2+ binding site [ion binding]; other site
93062002085	G-X-G motif; other site
93062002086	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062002087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062002088	active site
93062002089	phosphorylation site [posttranslational modification]
93062002090	intermolecular recognition site; other site
93062002091	dimerization interface [polypeptide binding]; other site
93062002092	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062002093	DNA binding site [nucleotide binding]
93062002094	DoxX; Region: DoxX; pfam07681
93062002095	Electron transfer DM13; Region: DM13; pfam10517
93062002096	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
93062002097	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
93062002098	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
93062002099	active site
93062002100	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
93062002101	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
93062002102	Ligand Binding Site [chemical binding]; other site
93062002103	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
93062002104	Glutamine amidotransferase class-I; Region: GATase; pfam00117
93062002105	glutamine binding [chemical binding]; other site
93062002106	catalytic triad [active]
93062002107	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
93062002108	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
93062002109	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
93062002110	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
93062002111	Sulfatase; Region: Sulfatase; pfam00884
93062002112	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
93062002113	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062002114	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062002115	ABC transporter; Region: ABC_tran_2; pfam12848
93062002116	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062002117	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
93062002118	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062002119	ATP binding site [chemical binding]; other site
93062002120	putative Mg++ binding site [ion binding]; other site
93062002121	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062002122	nucleotide binding region [chemical binding]; other site
93062002123	ATP-binding site [chemical binding]; other site
93062002124	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
93062002125	HRDC domain; Region: HRDC; pfam00570
93062002126	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
93062002127	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
93062002128	Walker A/P-loop; other site
93062002129	ATP binding site [chemical binding]; other site
93062002130	Q-loop/lid; other site
93062002131	ABC transporter signature motif; other site
93062002132	Walker B; other site
93062002133	D-loop; other site
93062002134	H-loop/switch region; other site
93062002135	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
93062002136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062002137	dimer interface [polypeptide binding]; other site
93062002138	conserved gate region; other site
93062002139	ABC-ATPase subunit interface; other site
93062002140	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
93062002141	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
93062002142	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
93062002143	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062002144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062002145	homodimer interface [polypeptide binding]; other site
93062002146	catalytic residue [active]
93062002147	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
93062002148	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
93062002149	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
93062002150	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
93062002151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062002152	putative substrate translocation pore; other site
93062002153	POT family; Region: PTR2; cl17359
93062002154	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
93062002155	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
93062002156	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
93062002157	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
93062002158	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
93062002159	Class I ribonucleotide reductase; Region: RNR_I; cd01679
93062002160	active site
93062002161	dimer interface [polypeptide binding]; other site
93062002162	catalytic residues [active]
93062002163	effector binding site; other site
93062002164	R2 peptide binding site; other site
93062002165	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
93062002166	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
93062002167	dimer interface [polypeptide binding]; other site
93062002168	putative radical transfer pathway; other site
93062002169	diiron center [ion binding]; other site
93062002170	tyrosyl radical; other site
93062002171	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062002172	ABC-ATPase subunit  interface; other site
93062002173	dimer interface [polypeptide binding]; other site
93062002174	putative PBP binding regions; other site
93062002175	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062002176	ABC-ATPase subunit  interface; other site
93062002177	dimer interface [polypeptide binding]; other site
93062002178	putative PBP binding regions; other site
93062002179	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
93062002180	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
93062002181	Walker A/P-loop; other site
93062002182	ATP binding site [chemical binding]; other site
93062002183	Q-loop/lid; other site
93062002184	ABC transporter signature motif; other site
93062002185	Walker B; other site
93062002186	D-loop; other site
93062002187	H-loop/switch region; other site
93062002188	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
93062002189	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
93062002190	putative ligand binding residues [chemical binding]; other site
93062002191	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
93062002192	CHY zinc finger; Region: zf-CHY; pfam05495
93062002193	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
93062002194	FAD binding domain; Region: FAD_binding_4; pfam01565
93062002195	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
93062002196	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
93062002197	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
93062002198	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
93062002199	peptidase T; Region: peptidase-T; TIGR01882
93062002200	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
93062002201	metal binding site [ion binding]; metal-binding site
93062002202	dimer interface [polypeptide binding]; other site
93062002203	Uncharacterized conserved protein [Function unknown]; Region: COG3610
93062002204	Uncharacterized conserved protein [Function unknown]; Region: COG2966
93062002205	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
93062002206	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
93062002207	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
93062002208	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
93062002209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
93062002210	metal binding site [ion binding]; metal-binding site
93062002211	active site
93062002212	I-site; other site
93062002213	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
93062002214	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
93062002215	Mg++ binding site [ion binding]; other site
93062002216	putative catalytic motif [active]
93062002217	substrate binding site [chemical binding]; other site
93062002218	Uncharacterized conserved protein [Function unknown]; Region: COG1739
93062002219	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
93062002220	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
93062002221	EDD domain protein, DegV family; Region: DegV; TIGR00762
93062002222	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
93062002223	DEAD-like helicases superfamily; Region: DEXDc; smart00487
93062002224	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062002225	ATP binding site [chemical binding]; other site
93062002226	putative Mg++ binding site [ion binding]; other site
93062002227	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062002228	nucleotide binding region [chemical binding]; other site
93062002229	ATP-binding site [chemical binding]; other site
93062002230	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
93062002231	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062002232	active site
93062002233	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
93062002234	30S subunit binding site; other site
93062002235	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
93062002236	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
93062002237	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
93062002238	nucleotide binding region [chemical binding]; other site
93062002239	ATP-binding site [chemical binding]; other site
93062002240	SEC-C motif; Region: SEC-C; pfam02810
93062002241	peptide chain release factor 2; Validated; Region: prfB; PRK00578
93062002242	This domain is found in peptide chain release factors; Region: PCRF; smart00937
93062002243	RF-1 domain; Region: RF-1; pfam00472
93062002244	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
93062002245	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062002246	Surface antigen [General function prediction only]; Region: COG3942
93062002247	CHAP domain; Region: CHAP; pfam05257
93062002248	HD domain; Region: HD_3; cl17350
93062002249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
93062002250	excinuclease ABC subunit B; Provisional; Region: PRK05298
93062002251	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062002252	ATP binding site [chemical binding]; other site
93062002253	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062002254	nucleotide binding region [chemical binding]; other site
93062002255	ATP-binding site [chemical binding]; other site
93062002256	Ultra-violet resistance protein B; Region: UvrB; pfam12344
93062002257	UvrB/uvrC motif; Region: UVR; pfam02151
93062002258	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
93062002259	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
93062002260	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
93062002261	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
93062002262	HPr kinase/phosphorylase; Provisional; Region: PRK05428
93062002263	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
93062002264	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
93062002265	Hpr binding site; other site
93062002266	active site
93062002267	homohexamer subunit interaction site [polypeptide binding]; other site
93062002268	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
93062002269	putative acyl transferase; Provisional; Region: PRK10191
93062002270	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
93062002271	trimer interface [polypeptide binding]; other site
93062002272	active site
93062002273	substrate binding site [chemical binding]; other site
93062002274	CoA binding site [chemical binding]; other site
93062002275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
93062002276	binding surface
93062002277	TPR motif; other site
93062002278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
93062002279	TPR motif; other site
93062002280	binding surface
93062002281	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
93062002282	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
93062002283	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062002284	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
93062002285	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
93062002286	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
93062002287	phosphate binding site [ion binding]; other site
93062002288	dimer interface [polypeptide binding]; other site
93062002289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
93062002290	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
93062002291	Clp protease; Region: CLP_protease; pfam00574
93062002292	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
93062002293	oligomer interface [polypeptide binding]; other site
93062002294	active site residues [active]
93062002295	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
93062002296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062002297	NAD(P) binding site [chemical binding]; other site
93062002298	active site
93062002299	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
93062002300	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
93062002301	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
93062002302	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
93062002303	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
93062002304	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
93062002305	Phosphoglycerate kinase; Region: PGK; pfam00162
93062002306	substrate binding site [chemical binding]; other site
93062002307	hinge regions; other site
93062002308	ADP binding site [chemical binding]; other site
93062002309	catalytic site [active]
93062002310	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
93062002311	triosephosphate isomerase; Provisional; Region: PRK14565
93062002312	substrate binding site [chemical binding]; other site
93062002313	dimer interface [polypeptide binding]; other site
93062002314	catalytic triad [active]
93062002315	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
93062002316	phosphoglyceromutase; Provisional; Region: PRK05434
93062002317	enolase; Provisional; Region: eno; PRK00077
93062002318	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
93062002319	dimer interface [polypeptide binding]; other site
93062002320	metal binding site [ion binding]; metal-binding site
93062002321	substrate binding pocket [chemical binding]; other site
93062002322	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
93062002323	Esterase/lipase [General function prediction only]; Region: COG1647
93062002324	Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735
93062002325	ribonuclease R; Region: RNase_R; TIGR02063
93062002326	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
93062002327	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
93062002328	RNB domain; Region: RNB; pfam00773
93062002329	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
93062002330	RNA binding site [nucleotide binding]; other site
93062002331	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
93062002332	SmpB-tmRNA interface; other site
93062002333	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062002334	Coenzyme A binding pocket [chemical binding]; other site
93062002335	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062002336	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062002337	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
93062002338	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
93062002339	Staphylococcal nuclease homologues; Region: SNc; smart00318
93062002340	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
93062002341	Catalytic site; other site
93062002342	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
93062002343	DNA-binding site [nucleotide binding]; DNA binding site
93062002344	RNA-binding motif; other site
93062002345	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
93062002346	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
93062002347	catalytic core [active]
93062002348	Lysine efflux permease [General function prediction only]; Region: COG1279
93062002349	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
93062002350	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
93062002351	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
93062002352	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
93062002353	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
93062002354	active site
93062002355	catalytic residue [active]
93062002356	dimer interface [polypeptide binding]; other site
93062002357	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
93062002358	putative FMN binding site [chemical binding]; other site
93062002359	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
93062002360	catalytic residues [active]
93062002361	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
93062002362	ArsC family; Region: ArsC; pfam03960
93062002363	putative ArsC-like catalytic residues; other site
93062002364	putative TRX-like catalytic residues [active]
93062002365	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
93062002366	lipoyl attachment site [posttranslational modification]; other site
93062002367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
93062002368	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
93062002369	putative active site [active]
93062002370	putative metal binding site [ion binding]; other site
93062002371	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
93062002372	catalytic residues [active]
93062002373	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
93062002374	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
93062002375	Walker A/P-loop; other site
93062002376	ATP binding site [chemical binding]; other site
93062002377	Q-loop/lid; other site
93062002378	ABC transporter signature motif; other site
93062002379	Walker B; other site
93062002380	D-loop; other site
93062002381	H-loop/switch region; other site
93062002382	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
93062002383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062002384	dimer interface [polypeptide binding]; other site
93062002385	conserved gate region; other site
93062002386	ABC-ATPase subunit interface; other site
93062002387	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
93062002388	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
93062002389	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
93062002390	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
93062002391	Int/Topo IB signature motif; other site
93062002392	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
93062002393	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062002394	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
93062002395	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062002396	Domain of unknown function (DUF955); Region: DUF955; pfam06114
93062002397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062002398	non-specific DNA binding site [nucleotide binding]; other site
93062002399	salt bridge; other site
93062002400	sequence-specific DNA binding site [nucleotide binding]; other site
93062002401	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062002402	non-specific DNA binding site [nucleotide binding]; other site
93062002403	salt bridge; other site
93062002404	sequence-specific DNA binding site [nucleotide binding]; other site
93062002405	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
93062002406	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
93062002407	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
93062002408	Virulence-associated protein E; Region: VirE; pfam05272
93062002409	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
93062002410	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
93062002411	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
93062002412	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062002413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
93062002414	Predicted membrane protein [Function unknown]; Region: COG2035
93062002415	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
93062002416	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
93062002417	Walker A/P-loop; other site
93062002418	ATP binding site [chemical binding]; other site
93062002419	Q-loop/lid; other site
93062002420	ABC transporter signature motif; other site
93062002421	Walker B; other site
93062002422	D-loop; other site
93062002423	H-loop/switch region; other site
93062002424	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
93062002425	FeS assembly protein SufD; Region: sufD; TIGR01981
93062002426	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
93062002427	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
93062002428	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062002429	catalytic residue [active]
93062002430	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
93062002431	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
93062002432	trimerization site [polypeptide binding]; other site
93062002433	active site
93062002434	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
93062002435	FeS assembly protein SufB; Region: sufB; TIGR01980
93062002436	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
93062002437	Domain of unknown function DUF21; Region: DUF21; pfam01595
93062002438	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
93062002439	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
93062002440	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
93062002441	FMN binding site [chemical binding]; other site
93062002442	substrate binding site [chemical binding]; other site
93062002443	putative catalytic residue [active]
93062002444	Uncharacterized conserved protein [Function unknown]; Region: COG1801
93062002445	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
93062002446	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
93062002447	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
93062002448	active site
93062002449	metal binding site [ion binding]; metal-binding site
93062002450	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
93062002451	lipoyl synthase; Provisional; Region: PRK05481
93062002452	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062002453	FeS/SAM binding site; other site
93062002454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
93062002455	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
93062002456	Uncharacterized conserved protein [Function unknown]; Region: COG2445
93062002457	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
93062002458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062002459	active site
93062002460	motif I; other site
93062002461	motif II; other site
93062002462	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062002463	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
93062002464	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
93062002465	dimerization interface [polypeptide binding]; other site
93062002466	ligand binding site [chemical binding]; other site
93062002467	NADP binding site [chemical binding]; other site
93062002468	catalytic site [active]
93062002469	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
93062002470	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
93062002471	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
93062002472	acyl-activating enzyme (AAE) consensus motif; other site
93062002473	AMP binding site [chemical binding]; other site
93062002474	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
93062002475	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
93062002476	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
93062002477	DltD N-terminal region; Region: DltD_N; pfam04915
93062002478	DltD central region; Region: DltD_M; pfam04918
93062002479	DltD C-terminal region; Region: DltD_C; pfam04914
93062002480	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
93062002481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
93062002482	hypothetical protein; Provisional; Region: PRK13669
93062002483	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
93062002484	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
93062002485	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062002486	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
93062002487	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
93062002488	interface (dimer of trimers) [polypeptide binding]; other site
93062002489	Substrate-binding/catalytic site; other site
93062002490	Zn-binding sites [ion binding]; other site
93062002491	Predicted permease [General function prediction only]; Region: COG2056
93062002492	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
93062002493	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
93062002494	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
93062002495	CoenzymeA binding site [chemical binding]; other site
93062002496	subunit interaction site [polypeptide binding]; other site
93062002497	PHB binding site; other site
93062002498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
93062002499	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
93062002500	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
93062002501	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
93062002502	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
93062002503	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
93062002504	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
93062002505	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
93062002506	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
93062002507	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
93062002508	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
93062002509	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
93062002510	Kinase associated protein B; Region: KapB; pfam08810
93062002511	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
93062002512	active site
93062002513	general stress protein 13; Validated; Region: PRK08059
93062002514	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
93062002515	RNA binding site [nucleotide binding]; other site
93062002516	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
93062002517	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
93062002518	putative active site [active]
93062002519	putative FMN binding site [chemical binding]; other site
93062002520	putative substrate binding site [chemical binding]; other site
93062002521	putative catalytic residue [active]
93062002522	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
93062002523	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
93062002524	inhibitor-cofactor binding pocket; inhibition site
93062002525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062002526	catalytic residue [active]
93062002527	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
93062002528	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
93062002529	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
93062002530	NAD(P) binding site [chemical binding]; other site
93062002531	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
93062002532	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
93062002533	active site
93062002534	catalytic site [active]
93062002535	metal binding site [ion binding]; metal-binding site
93062002536	argininosuccinate lyase; Provisional; Region: PRK00855
93062002537	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
93062002538	active sites [active]
93062002539	tetramer interface [polypeptide binding]; other site
93062002540	argininosuccinate synthase; Provisional; Region: PRK13820
93062002541	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
93062002542	ANP binding site [chemical binding]; other site
93062002543	Substrate Binding Site II [chemical binding]; other site
93062002544	Substrate Binding Site I [chemical binding]; other site
93062002545	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
93062002546	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
93062002547	active site
93062002548	dimer interface [polypeptide binding]; other site
93062002549	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
93062002550	dimer interface [polypeptide binding]; other site
93062002551	active site
93062002552	Uncharacterized conserved protein [Function unknown]; Region: COG0398
93062002553	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
93062002554	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
93062002555	Catalytic site [active]
93062002556	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
93062002557	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
93062002558	Catalytic site [active]
93062002559	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
93062002560	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
93062002561	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
93062002562	Part of AAA domain; Region: AAA_19; pfam13245
93062002563	Family description; Region: UvrD_C_2; pfam13538
93062002564	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
93062002565	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
93062002566	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
93062002567	hypothetical protein; Provisional; Region: PRK13673
93062002568	coenzyme A disulfide reductase; Provisional; Region: PRK13512
93062002569	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
93062002570	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062002571	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
93062002572	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
93062002573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062002574	active site
93062002575	motif I; other site
93062002576	motif II; other site
93062002577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062002578	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
93062002579	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
93062002580	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
93062002581	catalytic triad [active]
93062002582	catalytic triad [active]
93062002583	oxyanion hole [active]
93062002584	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
93062002585	Clp amino terminal domain; Region: Clp_N; pfam02861
93062002586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062002587	Walker A motif; other site
93062002588	ATP binding site [chemical binding]; other site
93062002589	Walker B motif; other site
93062002590	arginine finger; other site
93062002591	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
93062002592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062002593	Walker A motif; other site
93062002594	ATP binding site [chemical binding]; other site
93062002595	Walker B motif; other site
93062002596	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
93062002597	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062002598	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062002599	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
93062002600	dimerization interface [polypeptide binding]; other site
93062002601	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
93062002602	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
93062002603	active site
93062002604	catalytic residues [active]
93062002605	metal binding site [ion binding]; metal-binding site
93062002606	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
93062002607	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
93062002608	substrate binding site [chemical binding]; other site
93062002609	MAP domain; Region: MAP; pfam03642
93062002610	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
93062002611	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
93062002612	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
93062002613	dimer interface [polypeptide binding]; other site
93062002614	active site
93062002615	CoA binding pocket [chemical binding]; other site
93062002616	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
93062002617	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
93062002618	dimer interface [polypeptide binding]; other site
93062002619	active site
93062002620	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
93062002621	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
93062002622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062002623	dimer interface [polypeptide binding]; other site
93062002624	conserved gate region; other site
93062002625	putative PBP binding loops; other site
93062002626	ABC-ATPase subunit interface; other site
93062002627	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
93062002628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062002629	dimer interface [polypeptide binding]; other site
93062002630	conserved gate region; other site
93062002631	putative PBP binding loops; other site
93062002632	ABC-ATPase subunit interface; other site
93062002633	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
93062002634	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062002635	Walker A/P-loop; other site
93062002636	ATP binding site [chemical binding]; other site
93062002637	Q-loop/lid; other site
93062002638	ABC transporter signature motif; other site
93062002639	Walker B; other site
93062002640	D-loop; other site
93062002641	H-loop/switch region; other site
93062002642	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
93062002643	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
93062002644	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062002645	Walker A/P-loop; other site
93062002646	ATP binding site [chemical binding]; other site
93062002647	Q-loop/lid; other site
93062002648	ABC transporter signature motif; other site
93062002649	Walker B; other site
93062002650	D-loop; other site
93062002651	H-loop/switch region; other site
93062002652	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
93062002653	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
93062002654	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
93062002655	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
93062002656	peptide binding site [polypeptide binding]; other site
93062002657	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
93062002658	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
93062002659	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
93062002660	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062002661	Walker A/P-loop; other site
93062002662	ATP binding site [chemical binding]; other site
93062002663	Q-loop/lid; other site
93062002664	ABC transporter signature motif; other site
93062002665	Walker B; other site
93062002666	D-loop; other site
93062002667	H-loop/switch region; other site
93062002668	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
93062002669	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
93062002670	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062002671	Walker A/P-loop; other site
93062002672	ATP binding site [chemical binding]; other site
93062002673	Q-loop/lid; other site
93062002674	ABC transporter signature motif; other site
93062002675	Walker B; other site
93062002676	D-loop; other site
93062002677	H-loop/switch region; other site
93062002678	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
93062002679	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
93062002680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062002681	dimer interface [polypeptide binding]; other site
93062002682	conserved gate region; other site
93062002683	putative PBP binding loops; other site
93062002684	ABC-ATPase subunit interface; other site
93062002685	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
93062002686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062002687	dimer interface [polypeptide binding]; other site
93062002688	conserved gate region; other site
93062002689	putative PBP binding loops; other site
93062002690	ABC-ATPase subunit interface; other site
93062002691	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
93062002692	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
93062002693	active site
93062002694	HIGH motif; other site
93062002695	dimer interface [polypeptide binding]; other site
93062002696	KMSKS motif; other site
93062002697	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
93062002698	ArsC family; Region: ArsC; pfam03960
93062002699	putative catalytic residues [active]
93062002700	thiol/disulfide switch; other site
93062002701	adaptor protein; Provisional; Region: PRK02315
93062002702	Competence protein CoiA-like family; Region: CoiA; cl11541
93062002703	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
93062002704	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
93062002705	active site
93062002706	Zn binding site [ion binding]; other site
93062002707	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
93062002708	Thioredoxin; Region: Thioredoxin_5; pfam13743
93062002709	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
93062002710	apolar tunnel; other site
93062002711	heme binding site [chemical binding]; other site
93062002712	dimerization interface [polypeptide binding]; other site
93062002713	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
93062002714	putative active site [active]
93062002715	putative metal binding residues [ion binding]; other site
93062002716	signature motif; other site
93062002717	putative triphosphate binding site [ion binding]; other site
93062002718	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
93062002719	synthetase active site [active]
93062002720	NTP binding site [chemical binding]; other site
93062002721	metal binding site [ion binding]; metal-binding site
93062002722	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
93062002723	ATP-NAD kinase; Region: NAD_kinase; pfam01513
93062002724	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
93062002725	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
93062002726	active site
93062002727	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
93062002728	MgtE intracellular N domain; Region: MgtE_N; smart00924
93062002729	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
93062002730	Divalent cation transporter; Region: MgtE; pfam01769
93062002731	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
93062002732	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
93062002733	NAD binding site [chemical binding]; other site
93062002734	homotetramer interface [polypeptide binding]; other site
93062002735	homodimer interface [polypeptide binding]; other site
93062002736	substrate binding site [chemical binding]; other site
93062002737	active site
93062002738	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
93062002739	Domain of unknown function DUF20; Region: UPF0118; pfam01594
93062002740	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
93062002741	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
93062002742	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
93062002743	Putative esterase; Region: Esterase; pfam00756
93062002744	hypothetical protein; Provisional; Region: PRK13679
93062002745	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
93062002746	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062002747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062002748	putative substrate translocation pore; other site
93062002749	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
93062002750	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
93062002751	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
93062002752	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
93062002753	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
93062002754	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
93062002755	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
93062002756	YueH-like protein; Region: YueH; pfam14166
93062002757	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
93062002758	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
93062002759	G1 box; other site
93062002760	putative GEF interaction site [polypeptide binding]; other site
93062002761	GTP/Mg2+ binding site [chemical binding]; other site
93062002762	Switch I region; other site
93062002763	G2 box; other site
93062002764	G3 box; other site
93062002765	Switch II region; other site
93062002766	G4 box; other site
93062002767	G5 box; other site
93062002768	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
93062002769	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
93062002770	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
93062002771	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
93062002772	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
93062002773	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
93062002774	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
93062002775	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
93062002776	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
93062002777	active site
93062002778	metal binding site [ion binding]; metal-binding site
93062002779	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
93062002780	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
93062002781	IDEAL domain; Region: IDEAL; pfam08858
93062002782	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
93062002783	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
93062002784	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
93062002785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
93062002786	CAAX protease self-immunity; Region: Abi; pfam02517
93062002787	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
93062002788	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
93062002789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
93062002790	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
93062002791	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
93062002792	Walker A/P-loop; other site
93062002793	ATP binding site [chemical binding]; other site
93062002794	Q-loop/lid; other site
93062002795	ABC transporter signature motif; other site
93062002796	Walker B; other site
93062002797	D-loop; other site
93062002798	H-loop/switch region; other site
93062002799	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
93062002800	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
93062002801	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
93062002802	Predicted membrane protein [Function unknown]; Region: COG2259
93062002803	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
93062002804	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
93062002805	siderophore binding site; other site
93062002806	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
93062002807	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062002808	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
93062002809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
93062002810	Coenzyme A binding pocket [chemical binding]; other site
93062002811	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
93062002812	UbiA prenyltransferase family; Region: UbiA; pfam01040
93062002813	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
93062002814	isochorismate synthases; Region: isochor_syn; TIGR00543
93062002815	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
93062002816	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
93062002817	dimer interface [polypeptide binding]; other site
93062002818	tetramer interface [polypeptide binding]; other site
93062002819	PYR/PP interface [polypeptide binding]; other site
93062002820	TPP binding site [chemical binding]; other site
93062002821	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
93062002822	TPP-binding site; other site
93062002823	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
93062002824	PGAP1-like protein; Region: PGAP1; pfam07819
93062002825	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
93062002826	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
93062002827	substrate binding site [chemical binding]; other site
93062002828	oxyanion hole (OAH) forming residues; other site
93062002829	trimer interface [polypeptide binding]; other site
93062002830	Staphostatin B; Region: Staphostatin_B; pfam09023
93062002831	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
93062002832	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062002833	aminotransferase A; Validated; Region: PRK07683
93062002834	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062002835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062002836	homodimer interface [polypeptide binding]; other site
93062002837	catalytic residue [active]
93062002838	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
93062002839	Acyltransferase family; Region: Acyl_transf_3; pfam01757
93062002840	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062002841	MarR family; Region: MarR; pfam01047
93062002842	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
93062002843	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
93062002844	amidase catalytic site [active]
93062002845	Zn binding residues [ion binding]; other site
93062002846	substrate binding site [chemical binding]; other site
93062002847	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
93062002848	Lysozyme subfamily 2; Region: LYZ2; smart00047
93062002849	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062002850	Coenzyme A binding pocket [chemical binding]; other site
93062002851	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
93062002852	Transcriptional regulator [Transcription]; Region: LytR; COG1316
93062002853	Beta-lactamase; Region: Beta-lactamase; pfam00144
93062002854	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
93062002855	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
93062002856	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
93062002857	Subunit I/III interface [polypeptide binding]; other site
93062002858	Subunit III/IV interface [polypeptide binding]; other site
93062002859	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
93062002860	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
93062002861	D-pathway; other site
93062002862	Putative ubiquinol binding site [chemical binding]; other site
93062002863	Low-spin heme (heme b) binding site [chemical binding]; other site
93062002864	Putative water exit pathway; other site
93062002865	Binuclear center (heme o3/CuB) [ion binding]; other site
93062002866	K-pathway; other site
93062002867	Putative proton exit pathway; other site
93062002868	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
93062002869	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
93062002870	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
93062002871	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
93062002872	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
93062002873	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
93062002874	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
93062002875	homodimer interface [polypeptide binding]; other site
93062002876	NADP binding site [chemical binding]; other site
93062002877	substrate binding site [chemical binding]; other site
93062002878	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
93062002879	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
93062002880	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
93062002881	NAD binding site [chemical binding]; other site
93062002882	ATP-grasp domain; Region: ATP-grasp; pfam02222
93062002883	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
93062002884	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
93062002885	ATP binding site [chemical binding]; other site
93062002886	active site
93062002887	substrate binding site [chemical binding]; other site
93062002888	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
93062002889	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
93062002890	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
93062002891	putative active site [active]
93062002892	catalytic triad [active]
93062002893	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
93062002894	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
93062002895	dimerization interface [polypeptide binding]; other site
93062002896	ATP binding site [chemical binding]; other site
93062002897	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
93062002898	dimerization interface [polypeptide binding]; other site
93062002899	ATP binding site [chemical binding]; other site
93062002900	amidophosphoribosyltransferase; Provisional; Region: PRK07272
93062002901	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
93062002902	active site
93062002903	tetramer interface [polypeptide binding]; other site
93062002904	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062002905	active site
93062002906	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
93062002907	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
93062002908	dimerization interface [polypeptide binding]; other site
93062002909	putative ATP binding site [chemical binding]; other site
93062002910	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
93062002911	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
93062002912	active site
93062002913	substrate binding site [chemical binding]; other site
93062002914	cosubstrate binding site; other site
93062002915	catalytic site [active]
93062002916	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
93062002917	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
93062002918	purine monophosphate binding site [chemical binding]; other site
93062002919	dimer interface [polypeptide binding]; other site
93062002920	putative catalytic residues [active]
93062002921	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
93062002922	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
93062002923	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
93062002924	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
93062002925	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
93062002926	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
93062002927	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
93062002928	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
93062002929	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062002930	Walker A/P-loop; other site
93062002931	ATP binding site [chemical binding]; other site
93062002932	Q-loop/lid; other site
93062002933	ABC transporter signature motif; other site
93062002934	Walker B; other site
93062002935	D-loop; other site
93062002936	H-loop/switch region; other site
93062002937	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
93062002938	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062002939	Walker A/P-loop; other site
93062002940	ATP binding site [chemical binding]; other site
93062002941	Q-loop/lid; other site
93062002942	ABC transporter signature motif; other site
93062002943	Walker B; other site
93062002944	D-loop; other site
93062002945	H-loop/switch region; other site
93062002946	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
93062002947	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
93062002948	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
93062002949	putative RNA binding site [nucleotide binding]; other site
93062002950	Methyltransferase domain; Region: Methyltransf_26; pfam13659
93062002951	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
93062002952	dimerization domain swap beta strand [polypeptide binding]; other site
93062002953	regulatory protein interface [polypeptide binding]; other site
93062002954	active site
93062002955	regulatory phosphorylation site [posttranslational modification]; other site
93062002956	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
93062002957	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
93062002958	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
93062002959	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
93062002960	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
93062002961	catalytic residues [active]
93062002962	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
93062002963	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
93062002964	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
93062002965	TrkA-N domain; Region: TrkA_N; pfam02254
93062002966	TrkA-C domain; Region: TrkA_C; pfam02080
93062002967	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
93062002968	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
93062002969	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
93062002970	hypothetical protein; Provisional; Region: PRK13667
93062002971	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
93062002972	active site
93062002973	catalytic residues [active]
93062002974	metal binding site [ion binding]; metal-binding site
93062002975	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
93062002976	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
93062002977	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
93062002978	TPP-binding site [chemical binding]; other site
93062002979	tetramer interface [polypeptide binding]; other site
93062002980	heterodimer interface [polypeptide binding]; other site
93062002981	phosphorylation loop region [posttranslational modification]
93062002982	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
93062002983	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
93062002984	alpha subunit interface [polypeptide binding]; other site
93062002985	TPP binding site [chemical binding]; other site
93062002986	heterodimer interface [polypeptide binding]; other site
93062002987	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
93062002988	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
93062002989	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
93062002990	E3 interaction surface; other site
93062002991	lipoyl attachment site [posttranslational modification]; other site
93062002992	e3 binding domain; Region: E3_binding; pfam02817
93062002993	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
93062002994	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
93062002995	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
93062002996	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062002997	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
93062002998	hypothetical protein; Provisional; Region: PRK04387
93062002999	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
93062003000	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062003001	non-specific DNA binding site [nucleotide binding]; other site
93062003002	salt bridge; other site
93062003003	sequence-specific DNA binding site [nucleotide binding]; other site
93062003004	Cupin domain; Region: Cupin_2; pfam07883
93062003005	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
93062003006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062003007	Walker A/P-loop; other site
93062003008	ATP binding site [chemical binding]; other site
93062003009	Q-loop/lid; other site
93062003010	ABC transporter signature motif; other site
93062003011	Walker B; other site
93062003012	D-loop; other site
93062003013	H-loop/switch region; other site
93062003014	TOBE domain; Region: TOBE_2; pfam08402
93062003015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062003016	putative PBP binding loops; other site
93062003017	dimer interface [polypeptide binding]; other site
93062003018	ABC-ATPase subunit interface; other site
93062003019	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
93062003020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062003021	dimer interface [polypeptide binding]; other site
93062003022	conserved gate region; other site
93062003023	putative PBP binding loops; other site
93062003024	ABC-ATPase subunit interface; other site
93062003025	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
93062003026	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
93062003027	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
93062003028	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
93062003029	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
93062003030	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
93062003031	manganese transport protein MntH; Reviewed; Region: PRK00701
93062003032	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
93062003033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
93062003034	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
93062003035	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
93062003036	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
93062003037	active site
93062003038	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
93062003039	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
93062003040	G1 box; other site
93062003041	putative GEF interaction site [polypeptide binding]; other site
93062003042	GTP/Mg2+ binding site [chemical binding]; other site
93062003043	Switch I region; other site
93062003044	G2 box; other site
93062003045	G3 box; other site
93062003046	Switch II region; other site
93062003047	G4 box; other site
93062003048	G5 box; other site
93062003049	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
93062003050	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
93062003051	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
93062003052	hypothetical protein; Provisional; Region: PRK13666
93062003053	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
93062003054	pyruvate carboxylase; Reviewed; Region: PRK12999
93062003055	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
93062003056	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
93062003057	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
93062003058	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
93062003059	active site
93062003060	catalytic residues [active]
93062003061	metal binding site [ion binding]; metal-binding site
93062003062	homodimer binding site [polypeptide binding]; other site
93062003063	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
93062003064	carboxyltransferase (CT) interaction site; other site
93062003065	biotinylation site [posttranslational modification]; other site
93062003066	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
93062003067	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
93062003068	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
93062003069	UbiA prenyltransferase family; Region: UbiA; pfam01040
93062003070	Predicted membrane protein [Function unknown]; Region: COG2322
93062003071	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
93062003072	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
93062003073	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
93062003074	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
93062003075	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
93062003076	putative active site [active]
93062003077	catalytic site [active]
93062003078	putative metal binding site [ion binding]; other site
93062003079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
93062003080	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
93062003081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062003082	S-adenosylmethionine binding site [chemical binding]; other site
93062003083	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
93062003084	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
93062003085	active site
93062003086	(T/H)XGH motif; other site
93062003087	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
93062003088	hypothetical protein; Provisional; Region: PRK13670
93062003089	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
93062003090	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
93062003091	heme uptake protein IsdB; Region: IsdB; TIGR03657
93062003092	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062003093	NEAr Transporter domain; Region: NEAT; smart00725
93062003094	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
93062003095	heme-binding site [chemical binding]; other site
93062003096	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
93062003097	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
93062003098	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
93062003099	heme-binding site [chemical binding]; other site
93062003100	heme uptake protein IsdC; Region: IsdC; TIGR03656
93062003101	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
93062003102	heme-binding site [chemical binding]; other site
93062003103	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
93062003104	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
93062003105	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
93062003106	intersubunit interface [polypeptide binding]; other site
93062003107	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
93062003108	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062003109	ABC-ATPase subunit  interface; other site
93062003110	dimer interface [polypeptide binding]; other site
93062003111	putative PBP binding regions; other site
93062003112	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
93062003113	active site
93062003114	catalytic site [active]
93062003115	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
93062003116	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
93062003117	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
93062003118	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
93062003119	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
93062003120	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
93062003121	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
93062003122	dimer interface [polypeptide binding]; other site
93062003123	motif 1; other site
93062003124	active site
93062003125	motif 2; other site
93062003126	motif 3; other site
93062003127	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
93062003128	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
93062003129	putative tRNA-binding site [nucleotide binding]; other site
93062003130	B3/4 domain; Region: B3_4; pfam03483
93062003131	tRNA synthetase B5 domain; Region: B5; smart00874
93062003132	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
93062003133	dimer interface [polypeptide binding]; other site
93062003134	motif 1; other site
93062003135	motif 3; other site
93062003136	motif 2; other site
93062003137	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
93062003138	ribonuclease HIII; Provisional; Region: PRK00996
93062003139	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
93062003140	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
93062003141	RNA/DNA hybrid binding site [nucleotide binding]; other site
93062003142	active site
93062003143	Cell division protein ZapA; Region: ZapA; cl01146
93062003144	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
93062003145	Colicin V production protein; Region: Colicin_V; pfam02674
93062003146	hypothetical protein; Provisional; Region: PRK08609
93062003147	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
93062003148	active site
93062003149	primer binding site [nucleotide binding]; other site
93062003150	NTP  binding site [chemical binding]; other site
93062003151	metal binding triad [ion binding]; metal-binding site
93062003152	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
93062003153	active site
93062003154	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
93062003155	MutS domain III; Region: MutS_III; pfam05192
93062003156	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
93062003157	Walker A/P-loop; other site
93062003158	ATP binding site [chemical binding]; other site
93062003159	Q-loop/lid; other site
93062003160	ABC transporter signature motif; other site
93062003161	Walker B; other site
93062003162	D-loop; other site
93062003163	H-loop/switch region; other site
93062003164	Smr domain; Region: Smr; pfam01713
93062003165	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
93062003166	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
93062003167	catalytic residues [active]
93062003168	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
93062003169	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
93062003170	GIY-YIG motif/motif A; other site
93062003171	active site
93062003172	catalytic site [active]
93062003173	putative DNA binding site [nucleotide binding]; other site
93062003174	metal binding site [ion binding]; metal-binding site
93062003175	UvrB/uvrC motif; Region: UVR; pfam02151
93062003176	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
93062003177	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
93062003178	putative Iron-sulfur protein interface [polypeptide binding]; other site
93062003179	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
93062003180	proximal heme binding site [chemical binding]; other site
93062003181	distal heme binding site [chemical binding]; other site
93062003182	putative dimer interface [polypeptide binding]; other site
93062003183	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
93062003184	L-aspartate oxidase; Provisional; Region: PRK06175
93062003185	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
93062003186	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
93062003187	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
93062003188	glutamate racemase; Provisional; Region: PRK00865
93062003189	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
93062003190	active site
93062003191	dimerization interface [polypeptide binding]; other site
93062003192	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
93062003193	active site
93062003194	metal binding site [ion binding]; metal-binding site
93062003195	homotetramer interface [polypeptide binding]; other site
93062003196	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
93062003197	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
93062003198	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
93062003199	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
93062003200	beta-channel forming cytolysin; Region: hlyII; TIGR01002
93062003201	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
93062003202	superantigen-like protein; Reviewed; Region: PRK13350
93062003203	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062003204	superantigen-like protein; Reviewed; Region: PRK13349
93062003205	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062003206	superantigen-like protein; Reviewed; Region: PRK13043
93062003207	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062003208	ornithine carbamoyltransferase; Provisional; Region: PRK04284
93062003209	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
93062003210	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
93062003211	carbamate kinase; Reviewed; Region: PRK12686
93062003212	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
93062003213	putative substrate binding site [chemical binding]; other site
93062003214	nucleotide binding site [chemical binding]; other site
93062003215	nucleotide binding site [chemical binding]; other site
93062003216	homodimer interface [polypeptide binding]; other site
93062003217	Predicted membrane protein [Function unknown]; Region: COG1288
93062003218	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
93062003219	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
93062003220	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
93062003221	gating phenylalanine in ion channel; other site
93062003222	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
93062003223	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
93062003224	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
93062003225	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062003226	motif II; other site
93062003227	hypothetical protein; Provisional; Region: PRK13688
93062003228	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
93062003229	Coenzyme A binding pocket [chemical binding]; other site
93062003230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
93062003231	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
93062003232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
93062003233	MraZ protein; Region: MraZ; pfam02381
93062003234	MraZ protein; Region: MraZ; pfam02381
93062003235	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
93062003236	MraW methylase family; Region: Methyltransf_5; pfam01795
93062003237	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
93062003238	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
93062003239	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
93062003240	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
93062003241	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
93062003242	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
93062003243	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
93062003244	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
93062003245	Mg++ binding site [ion binding]; other site
93062003246	putative catalytic motif [active]
93062003247	putative substrate binding site [chemical binding]; other site
93062003248	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
93062003249	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
93062003250	NAD binding site [chemical binding]; other site
93062003251	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
93062003252	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
93062003253	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
93062003254	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
93062003255	Cell division protein FtsQ; Region: FtsQ; pfam03799
93062003256	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
93062003257	Cell division protein FtsA; Region: FtsA; smart00842
93062003258	Cell division protein FtsA; Region: FtsA; pfam14450
93062003259	cell division protein FtsZ; Validated; Region: PRK09330
93062003260	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
93062003261	nucleotide binding site [chemical binding]; other site
93062003262	SulA interaction site; other site
93062003263	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
93062003264	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
93062003265	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
93062003266	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
93062003267	catalytic residue [active]
93062003268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
93062003269	YGGT family; Region: YGGT; pfam02325
93062003270	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
93062003271	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062003272	RNA binding surface [nucleotide binding]; other site
93062003273	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
93062003274	DivIVA domain; Region: DivI1A_domain; TIGR03544
93062003275	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
93062003276	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
93062003277	HIGH motif; other site
93062003278	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
93062003279	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
93062003280	active site
93062003281	KMSKS motif; other site
93062003282	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
93062003283	tRNA binding surface [nucleotide binding]; other site
93062003284	anticodon binding site; other site
93062003285	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
93062003286	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
93062003287	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
93062003288	active site
93062003289	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
93062003290	lipoprotein signal peptidase; Provisional; Region: PRK14787
93062003291	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
93062003292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062003293	RNA binding surface [nucleotide binding]; other site
93062003294	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
93062003295	active site
93062003296	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
93062003297	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
93062003298	uracil transporter; Provisional; Region: PRK10720
93062003299	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
93062003300	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
93062003301	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
93062003302	dihydroorotase; Validated; Region: pyrC; PRK09357
93062003303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
93062003304	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
93062003305	active site
93062003306	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
93062003307	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
93062003308	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
93062003309	catalytic site [active]
93062003310	subunit interface [polypeptide binding]; other site
93062003311	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
93062003312	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
93062003313	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
93062003314	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
93062003315	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
93062003316	ATP-grasp domain; Region: ATP-grasp_4; cl17255
93062003317	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
93062003318	IMP binding site; other site
93062003319	dimer interface [polypeptide binding]; other site
93062003320	interdomain contacts; other site
93062003321	partial ornithine binding site; other site
93062003322	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
93062003323	active site
93062003324	dimer interface [polypeptide binding]; other site
93062003325	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062003326	active site
93062003327	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
93062003328	dimer interface [polypeptide binding]; other site
93062003329	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
93062003330	Domain of unknown function (DUF814); Region: DUF814; pfam05670
93062003331	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
93062003332	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
93062003333	catalytic site [active]
93062003334	G-X2-G-X-G-K; other site
93062003335	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
93062003336	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
93062003337	Flavoprotein; Region: Flavoprotein; pfam02441
93062003338	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
93062003339	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
93062003340	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062003341	ATP binding site [chemical binding]; other site
93062003342	putative Mg++ binding site [ion binding]; other site
93062003343	helicase superfamily c-terminal domain; Region: HELICc; smart00490
93062003344	nucleotide binding region [chemical binding]; other site
93062003345	ATP-binding site [chemical binding]; other site
93062003346	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
93062003347	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
93062003348	active site
93062003349	catalytic residues [active]
93062003350	metal binding site [ion binding]; metal-binding site
93062003351	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
93062003352	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
93062003353	putative active site [active]
93062003354	substrate binding site [chemical binding]; other site
93062003355	putative cosubstrate binding site; other site
93062003356	catalytic site [active]
93062003357	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
93062003358	substrate binding site [chemical binding]; other site
93062003359	16S rRNA methyltransferase B; Provisional; Region: PRK14902
93062003360	NusB family; Region: NusB; pfam01029
93062003361	putative RNA binding site [nucleotide binding]; other site
93062003362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062003363	S-adenosylmethionine binding site [chemical binding]; other site
93062003364	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
93062003365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062003366	FeS/SAM binding site; other site
93062003367	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
93062003368	Protein phosphatase 2C; Region: PP2C; pfam00481
93062003369	active site
93062003370	Predicted GTPases [General function prediction only]; Region: COG1162
93062003371	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
93062003372	RNA binding site [nucleotide binding]; other site
93062003373	homodimer interface [polypeptide binding]; other site
93062003374	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
93062003375	GTPase/Zn-binding domain interface [polypeptide binding]; other site
93062003376	GTP/Mg2+ binding site [chemical binding]; other site
93062003377	G4 box; other site
93062003378	G5 box; other site
93062003379	G1 box; other site
93062003380	Switch I region; other site
93062003381	G2 box; other site
93062003382	G3 box; other site
93062003383	Switch II region; other site
93062003384	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
93062003385	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
93062003386	substrate binding site [chemical binding]; other site
93062003387	hexamer interface [polypeptide binding]; other site
93062003388	metal binding site [ion binding]; metal-binding site
93062003389	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
93062003390	Thiamine pyrophosphokinase; Region: TPK; cd07995
93062003391	active site
93062003392	dimerization interface [polypeptide binding]; other site
93062003393	thiamine binding site [chemical binding]; other site
93062003394	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
93062003395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
93062003396	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
93062003397	DAK2 domain; Region: Dak2; pfam02734
93062003398	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
93062003399	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
93062003400	generic binding surface II; other site
93062003401	ssDNA binding site; other site
93062003402	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062003403	ATP binding site [chemical binding]; other site
93062003404	putative Mg++ binding site [ion binding]; other site
93062003405	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062003406	nucleotide binding region [chemical binding]; other site
93062003407	ATP-binding site [chemical binding]; other site
93062003408	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
93062003409	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
93062003410	active site 2 [active]
93062003411	active site 1 [active]
93062003412	putative phosphate acyltransferase; Provisional; Region: PRK05331
93062003413	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
93062003414	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
93062003415	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
93062003416	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
93062003417	NAD(P) binding site [chemical binding]; other site
93062003418	homotetramer interface [polypeptide binding]; other site
93062003419	homodimer interface [polypeptide binding]; other site
93062003420	active site
93062003421	acyl carrier protein; Provisional; Region: acpP; PRK00982
93062003422	ribonuclease III; Reviewed; Region: rnc; PRK00102
93062003423	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
93062003424	dimerization interface [polypeptide binding]; other site
93062003425	active site
93062003426	metal binding site [ion binding]; metal-binding site
93062003427	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
93062003428	dsRNA binding site [nucleotide binding]; other site
93062003429	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
93062003430	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
93062003431	Walker A/P-loop; other site
93062003432	ATP binding site [chemical binding]; other site
93062003433	Q-loop/lid; other site
93062003434	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
93062003435	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
93062003436	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
93062003437	ABC transporter signature motif; other site
93062003438	Walker B; other site
93062003439	D-loop; other site
93062003440	H-loop/switch region; other site
93062003441	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
93062003442	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
93062003443	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
93062003444	P loop; other site
93062003445	GTP binding site [chemical binding]; other site
93062003446	putative DNA-binding protein; Validated; Region: PRK00118
93062003447	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
93062003448	signal recognition particle protein; Provisional; Region: PRK10867
93062003449	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
93062003450	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
93062003451	P loop; other site
93062003452	GTP binding site [chemical binding]; other site
93062003453	Signal peptide binding domain; Region: SRP_SPB; pfam02978
93062003454	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
93062003455	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
93062003456	RimM N-terminal domain; Region: RimM; pfam01782
93062003457	PRC-barrel domain; Region: PRC; pfam05239
93062003458	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
93062003459	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
93062003460	Predicted membrane protein [Function unknown]; Region: COG4485
93062003461	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
93062003462	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
93062003463	GTP/Mg2+ binding site [chemical binding]; other site
93062003464	G4 box; other site
93062003465	G5 box; other site
93062003466	G1 box; other site
93062003467	Switch I region; other site
93062003468	G2 box; other site
93062003469	G3 box; other site
93062003470	Switch II region; other site
93062003471	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
93062003472	RNA/DNA hybrid binding site [nucleotide binding]; other site
93062003473	active site
93062003474	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
93062003475	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
93062003476	CoA-ligase; Region: Ligase_CoA; pfam00549
93062003477	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
93062003478	CoA binding domain; Region: CoA_binding; pfam02629
93062003479	CoA-ligase; Region: Ligase_CoA; pfam00549
93062003480	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
93062003481	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062003482	CHAP domain; Region: CHAP; pfam05257
93062003483	FemAB family; Region: FemAB; pfam02388
93062003484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
93062003485	DNA protecting protein DprA; Region: dprA; TIGR00732
93062003486	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
93062003487	DNA topoisomerase I; Validated; Region: PRK05582
93062003488	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
93062003489	active site
93062003490	interdomain interaction site; other site
93062003491	putative metal-binding site [ion binding]; other site
93062003492	nucleotide binding site [chemical binding]; other site
93062003493	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
93062003494	domain I; other site
93062003495	DNA binding groove [nucleotide binding]
93062003496	phosphate binding site [ion binding]; other site
93062003497	domain II; other site
93062003498	domain III; other site
93062003499	nucleotide binding site [chemical binding]; other site
93062003500	catalytic site [active]
93062003501	domain IV; other site
93062003502	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
93062003503	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
93062003504	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
93062003505	Glucose inhibited division protein A; Region: GIDA; pfam01134
93062003506	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
93062003507	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
93062003508	active site
93062003509	DNA binding site [nucleotide binding]
93062003510	Int/Topo IB signature motif; other site
93062003511	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
93062003512	active site
93062003513	HslU subunit interaction site [polypeptide binding]; other site
93062003514	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
93062003515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062003516	Walker A motif; other site
93062003517	ATP binding site [chemical binding]; other site
93062003518	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
93062003519	Walker B motif; other site
93062003520	arginine finger; other site
93062003521	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
93062003522	transcriptional repressor CodY; Validated; Region: PRK04158
93062003523	CodY GAF-like domain; Region: CodY; pfam06018
93062003524	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
93062003525	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
93062003526	rRNA interaction site [nucleotide binding]; other site
93062003527	S8 interaction site; other site
93062003528	putative laminin-1 binding site; other site
93062003529	elongation factor Ts; Provisional; Region: tsf; PRK09377
93062003530	UBA/TS-N domain; Region: UBA; pfam00627
93062003531	Elongation factor TS; Region: EF_TS; pfam00889
93062003532	Elongation factor TS; Region: EF_TS; pfam00889
93062003533	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
93062003534	putative nucleotide binding site [chemical binding]; other site
93062003535	uridine monophosphate binding site [chemical binding]; other site
93062003536	homohexameric interface [polypeptide binding]; other site
93062003537	ribosome recycling factor; Reviewed; Region: frr; PRK00083
93062003538	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
93062003539	hinge region; other site
93062003540	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
93062003541	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
93062003542	catalytic residue [active]
93062003543	putative FPP diphosphate  binding site; other site
93062003544	putative FPP binding hydrophobic cleft; other site
93062003545	dimer interface [polypeptide binding]; other site
93062003546	putative IPP diphosphate binding site; other site
93062003547	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
93062003548	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
93062003549	RIP metalloprotease RseP; Region: TIGR00054
93062003550	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
93062003551	active site
93062003552	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
93062003553	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
93062003554	protein binding site [polypeptide binding]; other site
93062003555	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
93062003556	putative substrate binding region [chemical binding]; other site
93062003557	prolyl-tRNA synthetase; Provisional; Region: PRK09194
93062003558	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
93062003559	dimer interface [polypeptide binding]; other site
93062003560	motif 1; other site
93062003561	active site
93062003562	motif 2; other site
93062003563	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
93062003564	putative deacylase active site [active]
93062003565	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
93062003566	active site
93062003567	motif 3; other site
93062003568	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
93062003569	anticodon binding site; other site
93062003570	DNA polymerase III PolC; Validated; Region: polC; PRK00448
93062003571	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
93062003572	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
93062003573	generic binding surface II; other site
93062003574	generic binding surface I; other site
93062003575	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
93062003576	active site
93062003577	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
93062003578	active site
93062003579	catalytic site [active]
93062003580	substrate binding site [chemical binding]; other site
93062003581	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
93062003582	ribosome maturation protein RimP; Reviewed; Region: PRK00092
93062003583	Sm and related proteins; Region: Sm_like; cl00259
93062003584	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
93062003585	putative oligomer interface [polypeptide binding]; other site
93062003586	putative RNA binding site [nucleotide binding]; other site
93062003587	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
93062003588	NusA N-terminal domain; Region: NusA_N; pfam08529
93062003589	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
93062003590	RNA binding site [nucleotide binding]; other site
93062003591	homodimer interface [polypeptide binding]; other site
93062003592	NusA-like KH domain; Region: KH_5; pfam13184
93062003593	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
93062003594	G-X-X-G motif; other site
93062003595	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
93062003596	putative RNA binding cleft [nucleotide binding]; other site
93062003597	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
93062003598	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
93062003599	translation initiation factor IF-2; Region: IF-2; TIGR00487
93062003600	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
93062003601	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
93062003602	G1 box; other site
93062003603	putative GEF interaction site [polypeptide binding]; other site
93062003604	GTP/Mg2+ binding site [chemical binding]; other site
93062003605	Switch I region; other site
93062003606	G2 box; other site
93062003607	G3 box; other site
93062003608	Switch II region; other site
93062003609	G4 box; other site
93062003610	G5 box; other site
93062003611	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
93062003612	Translation-initiation factor 2; Region: IF-2; pfam11987
93062003613	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
93062003614	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
93062003615	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
93062003616	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
93062003617	RNA binding site [nucleotide binding]; other site
93062003618	active site
93062003619	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
93062003620	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
93062003621	active site
93062003622	Riboflavin kinase; Region: Flavokinase; smart00904
93062003623	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
93062003624	16S/18S rRNA binding site [nucleotide binding]; other site
93062003625	S13e-L30e interaction site [polypeptide binding]; other site
93062003626	25S rRNA binding site [nucleotide binding]; other site
93062003627	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
93062003628	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
93062003629	RNase E interface [polypeptide binding]; other site
93062003630	trimer interface [polypeptide binding]; other site
93062003631	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
93062003632	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
93062003633	RNase E interface [polypeptide binding]; other site
93062003634	trimer interface [polypeptide binding]; other site
93062003635	active site
93062003636	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
93062003637	putative nucleic acid binding region [nucleotide binding]; other site
93062003638	G-X-X-G motif; other site
93062003639	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
93062003640	RNA binding site [nucleotide binding]; other site
93062003641	domain interface; other site
93062003642	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
93062003643	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
93062003644	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
93062003645	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
93062003646	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
93062003647	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
93062003648	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
93062003649	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
93062003650	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
93062003651	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
93062003652	DNA-binding site [nucleotide binding]; DNA binding site
93062003653	UTRA domain; Region: UTRA; pfam07702
93062003654	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
93062003655	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
93062003656	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
93062003657	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
93062003658	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
93062003659	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
93062003660	classical (c) SDRs; Region: SDR_c; cd05233
93062003661	NAD(P) binding site [chemical binding]; other site
93062003662	active site
93062003663	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
93062003664	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
93062003665	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
93062003666	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062003667	non-specific DNA binding site [nucleotide binding]; other site
93062003668	salt bridge; other site
93062003669	sequence-specific DNA binding site [nucleotide binding]; other site
93062003670	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
93062003671	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
93062003672	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
93062003673	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
93062003674	putative MPT binding site; other site
93062003675	recombinase A; Provisional; Region: recA; PRK09354
93062003676	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
93062003677	hexamer interface [polypeptide binding]; other site
93062003678	Walker A motif; other site
93062003679	ATP binding site [chemical binding]; other site
93062003680	Walker B motif; other site
93062003681	phosphodiesterase; Provisional; Region: PRK12704
93062003682	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
93062003683	Zn2+ binding site [ion binding]; other site
93062003684	Mg2+ binding site [ion binding]; other site
93062003685	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
93062003686	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
93062003687	putative active site [active]
93062003688	metal binding site [ion binding]; metal-binding site
93062003689	homodimer binding site [polypeptide binding]; other site
93062003690	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
93062003691	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
93062003692	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
93062003693	dimer interface [polypeptide binding]; other site
93062003694	PYR/PP interface [polypeptide binding]; other site
93062003695	TPP binding site [chemical binding]; other site
93062003696	substrate binding site [chemical binding]; other site
93062003697	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
93062003698	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
93062003699	TPP-binding site [chemical binding]; other site
93062003700	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
93062003701	Uncharacterized conserved protein [Function unknown]; Region: COG0011
93062003702	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
93062003703	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
93062003704	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062003705	FeS/SAM binding site; other site
93062003706	TRAM domain; Region: TRAM; pfam01938
93062003707	Predicted membrane protein [Function unknown]; Region: COG4550
93062003708	Predicted membrane protein [Function unknown]; Region: COG4732
93062003709	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
93062003710	MutS domain I; Region: MutS_I; pfam01624
93062003711	MutS domain II; Region: MutS_II; pfam05188
93062003712	MutS domain III; Region: MutS_III; pfam05192
93062003713	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
93062003714	Walker A/P-loop; other site
93062003715	ATP binding site [chemical binding]; other site
93062003716	Q-loop/lid; other site
93062003717	ABC transporter signature motif; other site
93062003718	Walker B; other site
93062003719	D-loop; other site
93062003720	H-loop/switch region; other site
93062003721	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
93062003722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062003723	ATP binding site [chemical binding]; other site
93062003724	Mg2+ binding site [ion binding]; other site
93062003725	G-X-G motif; other site
93062003726	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
93062003727	ATP binding site [chemical binding]; other site
93062003728	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
93062003729	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
93062003730	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
93062003731	amphipathic channel; other site
93062003732	Asn-Pro-Ala signature motifs; other site
93062003733	glycerol kinase; Provisional; Region: glpK; PRK00047
93062003734	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
93062003735	N- and C-terminal domain interface [polypeptide binding]; other site
93062003736	active site
93062003737	MgATP binding site [chemical binding]; other site
93062003738	catalytic site [active]
93062003739	metal binding site [ion binding]; metal-binding site
93062003740	glycerol binding site [chemical binding]; other site
93062003741	homotetramer interface [polypeptide binding]; other site
93062003742	homodimer interface [polypeptide binding]; other site
93062003743	FBP binding site [chemical binding]; other site
93062003744	protein IIAGlc interface [polypeptide binding]; other site
93062003745	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
93062003746	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
93062003747	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
93062003748	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
93062003749	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
93062003750	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
93062003751	bacterial Hfq-like; Region: Hfq; cd01716
93062003752	hexamer interface [polypeptide binding]; other site
93062003753	Sm1 motif; other site
93062003754	RNA binding site [nucleotide binding]; other site
93062003755	Sm2 motif; other site
93062003756	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
93062003757	catalytic residues [active]
93062003758	dimer interface [polypeptide binding]; other site
93062003759	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
93062003760	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
93062003761	HflX GTPase family; Region: HflX; cd01878
93062003762	G1 box; other site
93062003763	GTP/Mg2+ binding site [chemical binding]; other site
93062003764	Switch I region; other site
93062003765	G2 box; other site
93062003766	G3 box; other site
93062003767	Switch II region; other site
93062003768	G4 box; other site
93062003769	G5 box; other site
93062003770	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
93062003771	Aluminium resistance protein; Region: Alum_res; pfam06838
93062003772	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
93062003773	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
93062003774	DNA binding residues [nucleotide binding]
93062003775	putative dimer interface [polypeptide binding]; other site
93062003776	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
93062003777	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
93062003778	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
93062003779	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
93062003780	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
93062003781	Pathogenicity factor; Region: AvrE; pfam11725
93062003782	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
93062003783	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
93062003784	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
93062003785	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062003786	catalytic residue [active]
93062003787	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
93062003788	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
93062003789	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
93062003790	putative active site [active]
93062003791	catalytic site [active]
93062003792	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
93062003793	putative active site [active]
93062003794	catalytic site [active]
93062003795	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
93062003796	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
93062003797	Walker A/P-loop; other site
93062003798	ATP binding site [chemical binding]; other site
93062003799	Q-loop/lid; other site
93062003800	ABC transporter signature motif; other site
93062003801	Walker B; other site
93062003802	D-loop; other site
93062003803	H-loop/switch region; other site
93062003804	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
93062003805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
93062003806	Histidine kinase; Region: HisKA_3; pfam07730
93062003807	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
93062003808	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
93062003809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062003810	active site
93062003811	phosphorylation site [posttranslational modification]
93062003812	intermolecular recognition site; other site
93062003813	dimerization interface [polypeptide binding]; other site
93062003814	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
93062003815	DNA binding residues [nucleotide binding]
93062003816	dimerization interface [polypeptide binding]; other site
93062003817	Staphylococcal nuclease homologues; Region: SNc; smart00318
93062003818	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
93062003819	Catalytic site; other site
93062003820	AAA domain; Region: AAA_11; pfam13086
93062003821	aspartate kinase; Reviewed; Region: PRK09034
93062003822	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
93062003823	putative catalytic residues [active]
93062003824	putative nucleotide binding site [chemical binding]; other site
93062003825	putative aspartate binding site [chemical binding]; other site
93062003826	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
93062003827	allosteric regulatory residue; other site
93062003828	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
93062003829	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
93062003830	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
93062003831	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
93062003832	threonine synthase; Reviewed; Region: PRK06721
93062003833	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
93062003834	homodimer interface [polypeptide binding]; other site
93062003835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062003836	catalytic residue [active]
93062003837	homoserine kinase; Provisional; Region: PRK01212
93062003838	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
93062003839	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
93062003840	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062003841	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
93062003842	active site
93062003843	motif I; other site
93062003844	motif II; other site
93062003845	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
93062003846	lysine transporter; Provisional; Region: PRK10836
93062003847	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
93062003848	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
93062003849	tetramer interface [polypeptide binding]; other site
93062003850	heme binding pocket [chemical binding]; other site
93062003851	NADPH binding site [chemical binding]; other site
93062003852	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
93062003853	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
93062003854	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
93062003855	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
93062003856	active site
93062003857	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
93062003858	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
93062003859	LexA repressor; Validated; Region: PRK00215
93062003860	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
93062003861	putative DNA binding site [nucleotide binding]; other site
93062003862	putative Zn2+ binding site [ion binding]; other site
93062003863	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
93062003864	Catalytic site [active]
93062003865	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
93062003866	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
93062003867	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
93062003868	TPP-binding site [chemical binding]; other site
93062003869	dimer interface [polypeptide binding]; other site
93062003870	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
93062003871	PYR/PP interface [polypeptide binding]; other site
93062003872	dimer interface [polypeptide binding]; other site
93062003873	TPP binding site [chemical binding]; other site
93062003874	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
93062003875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
93062003876	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
93062003877	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
93062003878	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
93062003879	active site
93062003880	metal binding site [ion binding]; metal-binding site
93062003881	DNA binding site [nucleotide binding]
93062003882	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
93062003883	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
93062003884	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
93062003885	Walker A/P-loop; other site
93062003886	ATP binding site [chemical binding]; other site
93062003887	Q-loop/lid; other site
93062003888	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
93062003889	ABC transporter signature motif; other site
93062003890	Walker B; other site
93062003891	D-loop; other site
93062003892	H-loop/switch region; other site
93062003893	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
93062003894	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
93062003895	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
93062003896	aconitate hydratase; Validated; Region: PRK09277
93062003897	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
93062003898	substrate binding site [chemical binding]; other site
93062003899	ligand binding site [chemical binding]; other site
93062003900	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
93062003901	substrate binding site [chemical binding]; other site
93062003902	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
93062003903	active site
93062003904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
93062003905	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
93062003906	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
93062003907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062003908	ATP binding site [chemical binding]; other site
93062003909	Mg2+ binding site [ion binding]; other site
93062003910	G-X-G motif; other site
93062003911	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
93062003912	anchoring element; other site
93062003913	dimer interface [polypeptide binding]; other site
93062003914	ATP binding site [chemical binding]; other site
93062003915	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
93062003916	active site
93062003917	putative metal-binding site [ion binding]; other site
93062003918	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
93062003919	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
93062003920	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
93062003921	CAP-like domain; other site
93062003922	active site
93062003923	primary dimer interface [polypeptide binding]; other site
93062003924	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
93062003925	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
93062003926	amino acid carrier protein; Region: agcS; TIGR00835
93062003927	CAT RNA binding domain; Region: CAT_RBD; smart01061
93062003928	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
93062003929	PRD domain; Region: PRD; pfam00874
93062003930	PRD domain; Region: PRD; pfam00874
93062003931	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
93062003932	Domain of unknown function DUF20; Region: UPF0118; pfam01594
93062003933	Predicted integral membrane protein [Function unknown]; Region: COG0392
93062003934	Uncharacterized conserved protein [Function unknown]; Region: COG2898
93062003935	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
93062003936	methionine sulfoxide reductase A; Provisional; Region: PRK14054
93062003937	Transcriptional regulator [Transcription]; Region: LytR; COG1316
93062003938	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
93062003939	active site 1 [active]
93062003940	dimer interface [polypeptide binding]; other site
93062003941	hexamer interface [polypeptide binding]; other site
93062003942	active site 2 [active]
93062003943	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
93062003944	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
93062003945	active site
93062003946	DNA binding site [nucleotide binding]
93062003947	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
93062003948	prephenate dehydrogenase; Validated; Region: PRK06545
93062003949	prephenate dehydrogenase; Validated; Region: PRK08507
93062003950	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
93062003951	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
93062003952	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
93062003953	putative oligomer interface [polypeptide binding]; other site
93062003954	putative active site [active]
93062003955	metal binding site [ion binding]; metal-binding site
93062003956	anthranilate synthase component I; Provisional; Region: PRK13567
93062003957	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
93062003958	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
93062003959	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
93062003960	Glutamine amidotransferase class-I; Region: GATase; pfam00117
93062003961	glutamine binding [chemical binding]; other site
93062003962	catalytic triad [active]
93062003963	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
93062003964	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
93062003965	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
93062003966	active site
93062003967	ribulose/triose binding site [chemical binding]; other site
93062003968	phosphate binding site [ion binding]; other site
93062003969	substrate (anthranilate) binding pocket [chemical binding]; other site
93062003970	product (indole) binding pocket [chemical binding]; other site
93062003971	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
93062003972	active site
93062003973	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
93062003974	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
93062003975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062003976	catalytic residue [active]
93062003977	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
93062003978	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
93062003979	substrate binding site [chemical binding]; other site
93062003980	active site
93062003981	catalytic residues [active]
93062003982	heterodimer interface [polypeptide binding]; other site
93062003983	FemAB family; Region: FemAB; pfam02388
93062003984	FlxA-like protein; Region: FlxA; pfam14282
93062003985	FemAB family; Region: FemAB; pfam02388
93062003986	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
93062003987	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062003988	active site
93062003989	motif I; other site
93062003990	motif II; other site
93062003991	SWIM zinc finger; Region: SWIM; pfam04434
93062003992	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
93062003993	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062003994	Walker A/P-loop; other site
93062003995	ATP binding site [chemical binding]; other site
93062003996	Q-loop/lid; other site
93062003997	ABC transporter signature motif; other site
93062003998	Walker B; other site
93062003999	D-loop; other site
93062004000	H-loop/switch region; other site
93062004001	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062004002	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
93062004003	Walker A/P-loop; other site
93062004004	ATP binding site [chemical binding]; other site
93062004005	Q-loop/lid; other site
93062004006	ABC transporter signature motif; other site
93062004007	Walker B; other site
93062004008	D-loop; other site
93062004009	H-loop/switch region; other site
93062004010	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
93062004011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062004012	dimer interface [polypeptide binding]; other site
93062004013	conserved gate region; other site
93062004014	putative PBP binding loops; other site
93062004015	ABC-ATPase subunit interface; other site
93062004016	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
93062004017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062004018	dimer interface [polypeptide binding]; other site
93062004019	conserved gate region; other site
93062004020	putative PBP binding loops; other site
93062004021	ABC-ATPase subunit interface; other site
93062004022	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
93062004023	oligoendopeptidase F; Region: pepF; TIGR00181
93062004024	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
93062004025	active site
93062004026	Zn binding site [ion binding]; other site
93062004027	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
93062004028	PhoU domain; Region: PhoU; pfam01895
93062004029	PhoU domain; Region: PhoU; pfam01895
93062004030	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
93062004031	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
93062004032	Walker A/P-loop; other site
93062004033	ATP binding site [chemical binding]; other site
93062004034	Q-loop/lid; other site
93062004035	ABC transporter signature motif; other site
93062004036	Walker B; other site
93062004037	D-loop; other site
93062004038	H-loop/switch region; other site
93062004039	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
93062004040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062004041	dimer interface [polypeptide binding]; other site
93062004042	conserved gate region; other site
93062004043	putative PBP binding loops; other site
93062004044	ABC-ATPase subunit interface; other site
93062004045	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
93062004046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062004047	dimer interface [polypeptide binding]; other site
93062004048	conserved gate region; other site
93062004049	ABC-ATPase subunit interface; other site
93062004050	phosphate binding protein; Region: ptsS_2; TIGR02136
93062004051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
93062004052	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
93062004053	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
93062004054	S1 domain; Region: S1_2; pfam13509
93062004055	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
93062004056	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062004057	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062004058	ABC transporter; Region: ABC_tran_2; pfam12848
93062004059	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062004060	aspartate kinase; Reviewed; Region: PRK06635
93062004061	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
93062004062	putative nucleotide binding site [chemical binding]; other site
93062004063	putative catalytic residues [active]
93062004064	putative Mg ion binding site [ion binding]; other site
93062004065	putative aspartate binding site [chemical binding]; other site
93062004066	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
93062004067	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
93062004068	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
93062004069	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
93062004070	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
93062004071	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
93062004072	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
93062004073	dimer interface [polypeptide binding]; other site
93062004074	active site
93062004075	catalytic residue [active]
93062004076	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
93062004077	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
93062004078	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
93062004079	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
93062004080	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
93062004081	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
93062004082	active site
93062004083	trimer interface [polypeptide binding]; other site
93062004084	substrate binding site [chemical binding]; other site
93062004085	CoA binding site [chemical binding]; other site
93062004086	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
93062004087	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
93062004088	metal binding site [ion binding]; metal-binding site
93062004089	dimer interface [polypeptide binding]; other site
93062004090	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
93062004091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
93062004092	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
93062004093	catalytic residue [active]
93062004094	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
93062004095	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
93062004096	active site
93062004097	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
93062004098	substrate binding site [chemical binding]; other site
93062004099	catalytic residues [active]
93062004100	dimer interface [polypeptide binding]; other site
93062004101	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
93062004102	DNA-binding site [nucleotide binding]; DNA binding site
93062004103	RNA-binding motif; other site
93062004104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
93062004105	acylphosphatase; Provisional; Region: PRK14431
93062004106	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
93062004107	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
93062004108	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
93062004109	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
93062004110	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
93062004111	metal ion-dependent adhesion site (MIDAS); other site
93062004112	MoxR-like ATPases [General function prediction only]; Region: COG0714
93062004113	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062004114	Walker A motif; other site
93062004115	ATP binding site [chemical binding]; other site
93062004116	Walker B motif; other site
93062004117	arginine finger; other site
93062004118	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
93062004119	active site
93062004120	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
93062004121	active site
93062004122	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
93062004123	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
93062004124	E3 interaction surface; other site
93062004125	lipoyl attachment site [posttranslational modification]; other site
93062004126	e3 binding domain; Region: E3_binding; pfam02817
93062004127	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
93062004128	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
93062004129	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
93062004130	TPP-binding site [chemical binding]; other site
93062004131	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
93062004132	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
93062004133	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
93062004134	HAMP domain; Region: HAMP; pfam00672
93062004135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062004136	dimer interface [polypeptide binding]; other site
93062004137	phosphorylation site [posttranslational modification]
93062004138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062004139	ATP binding site [chemical binding]; other site
93062004140	Mg2+ binding site [ion binding]; other site
93062004141	G-X-G motif; other site
93062004142	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062004143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062004144	active site
93062004145	phosphorylation site [posttranslational modification]
93062004146	intermolecular recognition site; other site
93062004147	dimerization interface [polypeptide binding]; other site
93062004148	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062004149	DNA binding site [nucleotide binding]
93062004150	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
93062004151	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
93062004152	active site
93062004153	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
93062004154	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
93062004155	active site
93062004156	homodimer interface [polypeptide binding]; other site
93062004157	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
93062004158	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
93062004159	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
93062004160	protein binding site [polypeptide binding]; other site
93062004161	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
93062004162	Catalytic dyad [active]
93062004163	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
93062004164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
93062004165	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
93062004166	HPr interaction site; other site
93062004167	glycerol kinase (GK) interaction site [polypeptide binding]; other site
93062004168	active site
93062004169	phosphorylation site [posttranslational modification]
93062004170	EDD domain protein, DegV family; Region: DegV; TIGR00762
93062004171	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
93062004172	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
93062004173	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
93062004174	folate binding site [chemical binding]; other site
93062004175	NADP+ binding site [chemical binding]; other site
93062004176	thymidylate synthase; Region: thym_sym; TIGR03284
93062004177	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
93062004178	dimerization interface [polypeptide binding]; other site
93062004179	active site
93062004180	Disulphide isomerase; Region: Disulph_isomer; pfam06491
93062004181	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
93062004182	Virulence factor; Region: Virulence_fact; pfam13769
93062004183	HEAT repeats; Region: HEAT_2; pfam13646
93062004184	HEAT repeat; Region: HEAT; pfam02985
93062004185	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
93062004186	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
93062004187	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
93062004188	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
93062004189	RNA/DNA hybrid binding site [nucleotide binding]; other site
93062004190	active site
93062004191	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062004192	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
93062004193	GA module; Region: GA; smart00844
93062004194	GA module; Region: GA; smart00844
93062004195	GA module; Region: GA; smart00844
93062004196	GA module; Region: GA; smart00844
93062004197	GA module; Region: GA; smart00844
93062004198	GA module; Region: GA; smart00844
93062004199	GA module; Region: GA; smart00844
93062004200	GA module; Region: GA; smart00844
93062004201	GA module; Region: GA; smart00844
93062004202	GA module; Region: GA; smart00844
93062004203	GA module; Region: GA; smart00844
93062004204	GA module; Region: GA; smart00844
93062004205	GA module; Region: GA; smart00844
93062004206	GA module; Region: GA; smart00844
93062004207	GA module; Region: GA; smart00844
93062004208	GA module; Region: GA; smart00844
93062004209	GA module; Region: GA; smart00844
93062004210	GA module; Region: GA; smart00844
93062004211	GA module; Region: GA; smart00844
93062004212	GA module; Region: GA; pfam01468
93062004213	GA module; Region: GA; smart00844
93062004214	GA module; Region: GA; smart00844
93062004215	GA module; Region: GA; smart00844
93062004216	GA module; Region: GA; smart00844
93062004217	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
93062004218	GA module; Region: GA; smart00844
93062004219	GA module; Region: GA; smart00844
93062004220	GA module; Region: GA; smart00844
93062004221	GA module; Region: GA; smart00844
93062004222	GA module; Region: GA; smart00844
93062004223	GA module; Region: GA; smart00844
93062004224	GA module; Region: GA; smart00844
93062004225	GA module; Region: GA; pfam01468
93062004226	GA module; Region: GA; smart00844
93062004227	GA module; Region: GA; smart00844
93062004228	GA module; Region: GA; smart00844
93062004229	GA module; Region: GA; smart00844
93062004230	GA module; Region: GA; smart00844
93062004231	GA module; Region: GA; smart00844
93062004232	GA module; Region: GA; smart00844
93062004233	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
93062004234	GA module; Region: GA; smart00844
93062004235	GA module; Region: GA; smart00844
93062004236	GA module; Region: GA; smart00844
93062004237	GA module; Region: GA; smart00844
93062004238	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062004239	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062004240	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062004241	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
93062004242	Amino acid permease; Region: AA_permease_2; pfam13520
93062004243	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
93062004244	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
93062004245	tetramer interface [polypeptide binding]; other site
93062004246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062004247	catalytic residue [active]
93062004248	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
93062004249	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
93062004250	hexamer interface [polypeptide binding]; other site
93062004251	ligand binding site [chemical binding]; other site
93062004252	putative active site [active]
93062004253	NAD(P) binding site [chemical binding]; other site
93062004254	5'-3' exonuclease; Region: 53EXOc; smart00475
93062004255	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
93062004256	active site
93062004257	metal binding site 1 [ion binding]; metal-binding site
93062004258	putative 5' ssDNA interaction site; other site
93062004259	metal binding site 3; metal-binding site
93062004260	metal binding site 2 [ion binding]; metal-binding site
93062004261	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
93062004262	putative DNA binding site [nucleotide binding]; other site
93062004263	putative metal binding site [ion binding]; other site
93062004264	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
93062004265	Dynamin family; Region: Dynamin_N; pfam00350
93062004266	G1 box; other site
93062004267	GTP/Mg2+ binding site [chemical binding]; other site
93062004268	G2 box; other site
93062004269	Switch I region; other site
93062004270	G3 box; other site
93062004271	Switch II region; other site
93062004272	G4 box; other site
93062004273	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
93062004274	Dynamin family; Region: Dynamin_N; pfam00350
93062004275	G1 box; other site
93062004276	GTP/Mg2+ binding site [chemical binding]; other site
93062004277	G2 box; other site
93062004278	Switch I region; other site
93062004279	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
93062004280	G3 box; other site
93062004281	Switch II region; other site
93062004282	GTP/Mg2+ binding site [chemical binding]; other site
93062004283	G4 box; other site
93062004284	G5 box; other site
93062004285	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
93062004286	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
93062004287	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
93062004288	Cobalt transport protein component CbiN; Region: CbiN; cl00842
93062004289	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
93062004290	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
93062004291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
93062004292	cell division protein GpsB; Provisional; Region: PRK14127
93062004293	DivIVA domain; Region: DivI1A_domain; TIGR03544
93062004294	hypothetical protein; Provisional; Region: PRK13660
93062004295	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
93062004296	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
93062004297	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
93062004298	Transglycosylase; Region: Transgly; pfam00912
93062004299	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
93062004300	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
93062004301	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
93062004302	minor groove reading motif; other site
93062004303	helix-hairpin-helix signature motif; other site
93062004304	substrate binding pocket [chemical binding]; other site
93062004305	active site
93062004306	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
93062004307	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
93062004308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
93062004309	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
93062004310	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
93062004311	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
93062004312	putative dimer interface [polypeptide binding]; other site
93062004313	putative anticodon binding site; other site
93062004314	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
93062004315	homodimer interface [polypeptide binding]; other site
93062004316	motif 1; other site
93062004317	motif 2; other site
93062004318	active site
93062004319	motif 3; other site
93062004320	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
93062004321	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
93062004322	active site
93062004323	catalytic site [active]
93062004324	substrate binding site [chemical binding]; other site
93062004325	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
93062004326	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
93062004327	Biotin operon repressor [Transcription]; Region: BirA; COG1654
93062004328	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
93062004329	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
93062004330	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
93062004331	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
93062004332	active site
93062004333	NTP binding site [chemical binding]; other site
93062004334	metal binding triad [ion binding]; metal-binding site
93062004335	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
93062004336	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
93062004337	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
93062004338	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
93062004339	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
93062004340	homodimer interface [polypeptide binding]; other site
93062004341	metal binding site [ion binding]; metal-binding site
93062004342	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
93062004343	Predicted membrane protein [Function unknown]; Region: COG4347
93062004344	Uncharacterized conserved protein [Function unknown]; Region: COG5582
93062004345	UPF0302 domain; Region: UPF0302; pfam08864
93062004346	A short protein domain of unknown function; Region: IDEAL; smart00914
93062004347	TPR repeat; Region: TPR_11; pfam13414
93062004348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
93062004349	binding surface
93062004350	TPR motif; other site
93062004351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
93062004352	TPR motif; other site
93062004353	binding surface
93062004354	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
93062004355	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
93062004356	hinge; other site
93062004357	active site
93062004358	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
93062004359	active site
93062004360	NAD binding site [chemical binding]; other site
93062004361	metal binding site [ion binding]; metal-binding site
93062004362	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
93062004363	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
93062004364	Tetramer interface [polypeptide binding]; other site
93062004365	active site
93062004366	FMN-binding site [chemical binding]; other site
93062004367	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
93062004368	active site
93062004369	multimer interface [polypeptide binding]; other site
93062004370	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
93062004371	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
93062004372	substrate binding pocket [chemical binding]; other site
93062004373	chain length determination region; other site
93062004374	substrate-Mg2+ binding site; other site
93062004375	catalytic residues [active]
93062004376	aspartate-rich region 1; other site
93062004377	active site lid residues [active]
93062004378	aspartate-rich region 2; other site
93062004379	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
93062004380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062004381	S-adenosylmethionine binding site [chemical binding]; other site
93062004382	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
93062004383	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
93062004384	IHF dimer interface [polypeptide binding]; other site
93062004385	IHF - DNA interface [nucleotide binding]; other site
93062004386	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
93062004387	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
93062004388	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
93062004389	GTP-binding protein Der; Reviewed; Region: PRK00093
93062004390	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
93062004391	G1 box; other site
93062004392	GTP/Mg2+ binding site [chemical binding]; other site
93062004393	Switch I region; other site
93062004394	G2 box; other site
93062004395	Switch II region; other site
93062004396	G3 box; other site
93062004397	G4 box; other site
93062004398	G5 box; other site
93062004399	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
93062004400	G1 box; other site
93062004401	GTP/Mg2+ binding site [chemical binding]; other site
93062004402	Switch I region; other site
93062004403	G2 box; other site
93062004404	G3 box; other site
93062004405	Switch II region; other site
93062004406	G4 box; other site
93062004407	G5 box; other site
93062004408	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
93062004409	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
93062004410	RNA binding site [nucleotide binding]; other site
93062004411	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
93062004412	RNA binding site [nucleotide binding]; other site
93062004413	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
93062004414	RNA binding site [nucleotide binding]; other site
93062004415	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
93062004416	RNA binding site [nucleotide binding]; other site
93062004417	cytidylate kinase; Provisional; Region: cmk; PRK00023
93062004418	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
93062004419	CMP-binding site; other site
93062004420	The sites determining sugar specificity; other site
93062004421	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
93062004422	active site
93062004423	homotetramer interface [polypeptide binding]; other site
93062004424	homodimer interface [polypeptide binding]; other site
93062004425	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
93062004426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
93062004427	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062004428	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
93062004429	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
93062004430	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062004431	ATP binding site [chemical binding]; other site
93062004432	putative Mg++ binding site [ion binding]; other site
93062004433	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062004434	nucleotide binding region [chemical binding]; other site
93062004435	ATP-binding site [chemical binding]; other site
93062004436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
93062004437	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
93062004438	Predicted membrane protein [Function unknown]; Region: COG3601
93062004439	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
93062004440	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
93062004441	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
93062004442	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
93062004443	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
93062004444	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
93062004445	dimerization interface [polypeptide binding]; other site
93062004446	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
93062004447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062004448	dimer interface [polypeptide binding]; other site
93062004449	phosphorylation site [posttranslational modification]
93062004450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062004451	ATP binding site [chemical binding]; other site
93062004452	Mg2+ binding site [ion binding]; other site
93062004453	G-X-G motif; other site
93062004454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062004455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062004456	active site
93062004457	phosphorylation site [posttranslational modification]
93062004458	intermolecular recognition site; other site
93062004459	dimerization interface [polypeptide binding]; other site
93062004460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062004461	DNA binding site [nucleotide binding]
93062004462	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
93062004463	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062004464	RNA binding surface [nucleotide binding]; other site
93062004465	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
93062004466	active site
93062004467	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
93062004468	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
93062004469	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
93062004470	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
93062004471	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
93062004472	active site
93062004473	Int/Topo IB signature motif; other site
93062004474	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
93062004475	metal binding site 2 [ion binding]; metal-binding site
93062004476	putative DNA binding helix; other site
93062004477	metal binding site 1 [ion binding]; metal-binding site
93062004478	dimer interface [polypeptide binding]; other site
93062004479	structural Zn2+ binding site [ion binding]; other site
93062004480	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
93062004481	dimer interface [polypeptide binding]; other site
93062004482	ADP-ribose binding site [chemical binding]; other site
93062004483	active site
93062004484	nudix motif; other site
93062004485	metal binding site [ion binding]; metal-binding site
93062004486	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
93062004487	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
93062004488	active site
93062004489	catalytic tetrad [active]
93062004490	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
93062004491	classical (c) SDRs; Region: SDR_c; cd05233
93062004492	NAD(P) binding site [chemical binding]; other site
93062004493	active site
93062004494	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
93062004495	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
93062004496	ribonuclease Z; Region: RNase_Z; TIGR02651
93062004497	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
93062004498	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
93062004499	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
93062004500	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
93062004501	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
93062004502	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
93062004503	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
93062004504	Ca binding site [ion binding]; other site
93062004505	active site
93062004506	catalytic site [active]
93062004507	Transcriptional regulators [Transcription]; Region: PurR; COG1609
93062004508	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
93062004509	DNA binding site [nucleotide binding]
93062004510	domain linker motif; other site
93062004511	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
93062004512	putative ligand binding site [chemical binding]; other site
93062004513	putative dimerization interface [polypeptide binding]; other site
93062004514	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
93062004515	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
93062004516	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
93062004517	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
93062004518	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
93062004519	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
93062004520	peptidase T-like protein; Region: PepT-like; TIGR01883
93062004521	metal binding site [ion binding]; metal-binding site
93062004522	putative dimer interface [polypeptide binding]; other site
93062004523	Predicted membrane protein [Function unknown]; Region: COG4129
93062004524	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
93062004525	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
93062004526	Disulphide isomerase; Region: Disulph_isomer; pfam06491
93062004527	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
93062004528	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
93062004529	E3 interaction surface; other site
93062004530	lipoyl attachment site [posttranslational modification]; other site
93062004531	e3 binding domain; Region: E3_binding; pfam02817
93062004532	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
93062004533	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
93062004534	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
93062004535	alpha subunit interface [polypeptide binding]; other site
93062004536	TPP binding site [chemical binding]; other site
93062004537	heterodimer interface [polypeptide binding]; other site
93062004538	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
93062004539	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
93062004540	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
93062004541	tetramer interface [polypeptide binding]; other site
93062004542	TPP-binding site [chemical binding]; other site
93062004543	heterodimer interface [polypeptide binding]; other site
93062004544	phosphorylation loop region [posttranslational modification]
93062004545	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
93062004546	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
93062004547	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062004548	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
93062004549	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
93062004550	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
93062004551	Walker A/P-loop; other site
93062004552	ATP binding site [chemical binding]; other site
93062004553	Q-loop/lid; other site
93062004554	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
93062004555	ABC transporter signature motif; other site
93062004556	Walker B; other site
93062004557	D-loop; other site
93062004558	H-loop/switch region; other site
93062004559	arginine repressor; Provisional; Region: PRK04280
93062004560	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
93062004561	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
93062004562	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
93062004563	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
93062004564	substrate binding pocket [chemical binding]; other site
93062004565	chain length determination region; other site
93062004566	substrate-Mg2+ binding site; other site
93062004567	catalytic residues [active]
93062004568	aspartate-rich region 1; other site
93062004569	active site lid residues [active]
93062004570	aspartate-rich region 2; other site
93062004571	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
93062004572	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
93062004573	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
93062004574	generic binding surface II; other site
93062004575	generic binding surface I; other site
93062004576	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
93062004577	putative RNA binding site [nucleotide binding]; other site
93062004578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
93062004579	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
93062004580	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
93062004581	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
93062004582	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
93062004583	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
93062004584	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
93062004585	carboxyltransferase (CT) interaction site; other site
93062004586	biotinylation site [posttranslational modification]; other site
93062004587	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
93062004588	Surface antigen [General function prediction only]; Region: COG3942
93062004589	CHAP domain; Region: CHAP; pfam05257
93062004590	ribonuclease E; Reviewed; Region: rne; PRK10811
93062004591	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
93062004592	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
93062004593	AAA-like domain; Region: AAA_10; pfam12846
93062004594	TcpE family; Region: TcpE; pfam12648
93062004595	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
93062004596	Replication initiation factor; Region: Rep_trans; pfam02486
93062004597	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
93062004598	elongation factor P; Validated; Region: PRK00529
93062004599	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
93062004600	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
93062004601	RNA binding site [nucleotide binding]; other site
93062004602	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
93062004603	RNA binding site [nucleotide binding]; other site
93062004604	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
93062004605	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
93062004606	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
93062004607	active site
93062004608	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
93062004609	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
93062004610	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062004611	active site residue [active]
93062004612	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
93062004613	tetramer interface [polypeptide binding]; other site
93062004614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062004615	catalytic residue [active]
93062004616	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
93062004617	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
93062004618	tetramer interface [polypeptide binding]; other site
93062004619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062004620	catalytic residue [active]
93062004621	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
93062004622	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
93062004623	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
93062004624	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
93062004625	ADP binding site [chemical binding]; other site
93062004626	magnesium binding site [ion binding]; other site
93062004627	putative shikimate binding site; other site
93062004628	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
93062004629	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
93062004630	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
93062004631	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
93062004632	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
93062004633	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
93062004634	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
93062004635	Type II/IV secretion system protein; Region: T2SE; pfam00437
93062004636	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
93062004637	Walker A motif; other site
93062004638	ATP binding site [chemical binding]; other site
93062004639	Walker B motif; other site
93062004640	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
93062004641	Uncharacterized conserved protein [Function unknown]; Region: COG0011
93062004642	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
93062004643	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
93062004644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
93062004645	Rhomboid family; Region: Rhomboid; pfam01694
93062004646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
93062004647	binding surface
93062004648	TPR motif; other site
93062004649	Tetratricopeptide repeat; Region: TPR_16; pfam13432
93062004650	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
93062004651	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
93062004652	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
93062004653	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
93062004654	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
93062004655	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
93062004656	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
93062004657	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
93062004658	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
93062004659	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
93062004660	metal binding site 2 [ion binding]; metal-binding site
93062004661	putative DNA binding helix; other site
93062004662	metal binding site 1 [ion binding]; metal-binding site
93062004663	dimer interface [polypeptide binding]; other site
93062004664	structural Zn2+ binding site [ion binding]; other site
93062004665	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
93062004666	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062004667	ABC-ATPase subunit  interface; other site
93062004668	dimer interface [polypeptide binding]; other site
93062004669	putative PBP binding regions; other site
93062004670	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
93062004671	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
93062004672	endonuclease IV; Provisional; Region: PRK01060
93062004673	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
93062004674	AP (apurinic/apyrimidinic) site pocket; other site
93062004675	DNA interaction; other site
93062004676	Metal-binding active site; metal-binding site
93062004677	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
93062004678	DEAD-like helicases superfamily; Region: DEXDc; smart00487
93062004679	ATP binding site [chemical binding]; other site
93062004680	Mg++ binding site [ion binding]; other site
93062004681	motif III; other site
93062004682	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062004683	nucleotide binding region [chemical binding]; other site
93062004684	ATP-binding site [chemical binding]; other site
93062004685	Uncharacterized conserved protein [Function unknown]; Region: COG0327
93062004686	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
93062004687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
93062004688	Uncharacterized conserved protein [Function unknown]; Region: COG0327
93062004689	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
93062004690	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
93062004691	Family of unknown function (DUF633); Region: DUF633; pfam04816
93062004692	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
93062004693	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
93062004694	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
93062004695	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
93062004696	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
93062004697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
93062004698	DNA binding residues [nucleotide binding]
93062004699	DNA primase, catalytic core; Region: dnaG; TIGR01391
93062004700	CHC2 zinc finger; Region: zf-CHC2; pfam01807
93062004701	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
93062004702	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
93062004703	active site
93062004704	metal binding site [ion binding]; metal-binding site
93062004705	interdomain interaction site; other site
93062004706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
93062004707	HTH domain; Region: HTH_11; cl17392
93062004708	FOG: CBS domain [General function prediction only]; Region: COG0517
93062004709	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
93062004710	glycyl-tRNA synthetase; Provisional; Region: PRK04173
93062004711	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
93062004712	motif 1; other site
93062004713	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
93062004714	active site
93062004715	motif 2; other site
93062004716	motif 3; other site
93062004717	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
93062004718	anticodon binding site; other site
93062004719	DNA repair protein RecO; Region: reco; TIGR00613
93062004720	Recombination protein O N terminal; Region: RecO_N; pfam11967
93062004721	Recombination protein O C terminal; Region: RecO_C; pfam02565
93062004722	GTPase Era; Reviewed; Region: era; PRK00089
93062004723	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
93062004724	G1 box; other site
93062004725	GTP/Mg2+ binding site [chemical binding]; other site
93062004726	Switch I region; other site
93062004727	G2 box; other site
93062004728	Switch II region; other site
93062004729	G3 box; other site
93062004730	G4 box; other site
93062004731	G5 box; other site
93062004732	KH domain; Region: KH_2; pfam07650
93062004733	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
93062004734	active site
93062004735	catalytic motif [active]
93062004736	Zn binding site [ion binding]; other site
93062004737	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
93062004738	metal-binding heat shock protein; Provisional; Region: PRK00016
93062004739	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
93062004740	PhoH-like protein; Region: PhoH; pfam02562
93062004741	hypothetical protein; Provisional; Region: PRK13665
93062004742	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
93062004743	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
93062004744	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
93062004745	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
93062004746	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062004747	FeS/SAM binding site; other site
93062004748	TRAM domain; Region: TRAM; cl01282
93062004749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
93062004750	RNA methyltransferase, RsmE family; Region: TIGR00046
93062004751	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
93062004752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062004753	S-adenosylmethionine binding site [chemical binding]; other site
93062004754	chaperone protein DnaJ; Provisional; Region: PRK14280
93062004755	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
93062004756	HSP70 interaction site [polypeptide binding]; other site
93062004757	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
93062004758	substrate binding site [polypeptide binding]; other site
93062004759	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
93062004760	Zn binding sites [ion binding]; other site
93062004761	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
93062004762	dimer interface [polypeptide binding]; other site
93062004763	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
93062004764	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
93062004765	nucleotide binding site [chemical binding]; other site
93062004766	NEF interaction site [polypeptide binding]; other site
93062004767	SBD interface [polypeptide binding]; other site
93062004768	heat shock protein GrpE; Provisional; Region: PRK14140
93062004769	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
93062004770	dimer interface [polypeptide binding]; other site
93062004771	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
93062004772	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
93062004773	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
93062004774	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
93062004775	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
93062004776	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062004777	FeS/SAM binding site; other site
93062004778	HemN C-terminal domain; Region: HemN_C; pfam06969
93062004779	GTP-binding protein LepA; Provisional; Region: PRK05433
93062004780	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
93062004781	G1 box; other site
93062004782	putative GEF interaction site [polypeptide binding]; other site
93062004783	GTP/Mg2+ binding site [chemical binding]; other site
93062004784	Switch I region; other site
93062004785	G2 box; other site
93062004786	G3 box; other site
93062004787	Switch II region; other site
93062004788	G4 box; other site
93062004789	G5 box; other site
93062004790	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
93062004791	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
93062004792	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
93062004793	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
93062004794	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
93062004795	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
93062004796	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
93062004797	Competence protein; Region: Competence; pfam03772
93062004798	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
93062004799	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
93062004800	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
93062004801	catalytic motif [active]
93062004802	Zn binding site [ion binding]; other site
93062004803	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
93062004804	SLBB domain; Region: SLBB; pfam10531
93062004805	Helix-hairpin-helix motif; Region: HHH; pfam00633
93062004806	Methyltransferase domain; Region: Methyltransf_31; pfam13847
93062004807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062004808	S-adenosylmethionine binding site [chemical binding]; other site
93062004809	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
93062004810	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
93062004811	Zn2+ binding site [ion binding]; other site
93062004812	Mg2+ binding site [ion binding]; other site
93062004813	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
93062004814	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
93062004815	active site
93062004816	(T/H)XGH motif; other site
93062004817	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
93062004818	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
93062004819	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
93062004820	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
93062004821	shikimate binding site; other site
93062004822	NAD(P) binding site [chemical binding]; other site
93062004823	GTPase YqeH; Provisional; Region: PRK13796
93062004824	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
93062004825	GTP/Mg2+ binding site [chemical binding]; other site
93062004826	G4 box; other site
93062004827	G5 box; other site
93062004828	G1 box; other site
93062004829	Switch I region; other site
93062004830	G2 box; other site
93062004831	G3 box; other site
93062004832	Switch II region; other site
93062004833	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
93062004834	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062004835	active site
93062004836	motif I; other site
93062004837	motif II; other site
93062004838	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
93062004839	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
93062004840	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
93062004841	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
93062004842	Fic family protein [Function unknown]; Region: COG3177
93062004843	Fic/DOC family; Region: Fic; pfam02661
93062004844	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
93062004845	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
93062004846	putative active site [active]
93062004847	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
93062004848	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
93062004849	ATP-grasp domain; Region: ATP-grasp_4; cl17255
93062004850	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
93062004851	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
93062004852	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
93062004853	carboxyltransferase (CT) interaction site; other site
93062004854	biotinylation site [posttranslational modification]; other site
93062004855	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
93062004856	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
93062004857	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
93062004858	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
93062004859	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
93062004860	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
93062004861	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
93062004862	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
93062004863	Sugar specificity; other site
93062004864	Pyrimidine base specificity; other site
93062004865	ATP-binding site [chemical binding]; other site
93062004866	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
93062004867	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
93062004868	Peptidase family U32; Region: Peptidase_U32; pfam01136
93062004869	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
93062004870	Peptidase family U32; Region: Peptidase_U32; pfam01136
93062004871	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
93062004872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062004873	S-adenosylmethionine binding site [chemical binding]; other site
93062004874	hypothetical protein; Provisional; Region: PRK13678
93062004875	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
93062004876	hypothetical protein; Provisional; Region: PRK05473
93062004877	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
93062004878	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
93062004879	motif 1; other site
93062004880	active site
93062004881	motif 2; other site
93062004882	motif 3; other site
93062004883	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
93062004884	DHHA1 domain; Region: DHHA1; pfam02272
93062004885	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
93062004886	AAA domain; Region: AAA_30; pfam13604
93062004887	Family description; Region: UvrD_C_2; pfam13538
93062004888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
93062004889	binding surface
93062004890	TPR motif; other site
93062004891	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
93062004892	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
93062004893	binding surface
93062004894	TPR motif; other site
93062004895	TPR repeat; Region: TPR_11; pfam13414
93062004896	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
93062004897	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
93062004898	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
93062004899	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
93062004900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062004901	catalytic residue [active]
93062004902	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
93062004903	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
93062004904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
93062004905	Predicted transcriptional regulator [Transcription]; Region: COG1959
93062004906	Transcriptional regulator; Region: Rrf2; pfam02082
93062004907	recombination factor protein RarA; Reviewed; Region: PRK13342
93062004908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062004909	Walker A motif; other site
93062004910	ATP binding site [chemical binding]; other site
93062004911	Walker B motif; other site
93062004912	arginine finger; other site
93062004913	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
93062004914	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
93062004915	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
93062004916	putative ATP binding site [chemical binding]; other site
93062004917	putative substrate interface [chemical binding]; other site
93062004918	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
93062004919	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
93062004920	dimer interface [polypeptide binding]; other site
93062004921	anticodon binding site; other site
93062004922	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
93062004923	homodimer interface [polypeptide binding]; other site
93062004924	motif 1; other site
93062004925	active site
93062004926	motif 2; other site
93062004927	GAD domain; Region: GAD; pfam02938
93062004928	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
93062004929	motif 3; other site
93062004930	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
93062004931	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
93062004932	dimer interface [polypeptide binding]; other site
93062004933	motif 1; other site
93062004934	active site
93062004935	motif 2; other site
93062004936	motif 3; other site
93062004937	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
93062004938	anticodon binding site; other site
93062004939	Bacterial SH3 domain homologues; Region: SH3b; smart00287
93062004940	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
93062004941	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
93062004942	active site
93062004943	metal binding site [ion binding]; metal-binding site
93062004944	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
93062004945	putative active site [active]
93062004946	dimerization interface [polypeptide binding]; other site
93062004947	putative tRNAtyr binding site [nucleotide binding]; other site
93062004948	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
93062004949	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
93062004950	Zn2+ binding site [ion binding]; other site
93062004951	Mg2+ binding site [ion binding]; other site
93062004952	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
93062004953	synthetase active site [active]
93062004954	NTP binding site [chemical binding]; other site
93062004955	metal binding site [ion binding]; metal-binding site
93062004956	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
93062004957	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
93062004958	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062004959	active site
93062004960	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
93062004961	DHH family; Region: DHH; pfam01368
93062004962	DHHA1 domain; Region: DHHA1; pfam02272
93062004963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
93062004964	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
93062004965	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
93062004966	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
93062004967	Protein export membrane protein; Region: SecD_SecF; pfam02355
93062004968	Preprotein translocase subunit; Region: YajC; pfam02699
93062004969	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
93062004970	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
93062004971	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
93062004972	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
93062004973	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
93062004974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062004975	Walker A motif; other site
93062004976	ATP binding site [chemical binding]; other site
93062004977	Walker B motif; other site
93062004978	arginine finger; other site
93062004979	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
93062004980	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
93062004981	RuvA N terminal domain; Region: RuvA_N; pfam01330
93062004982	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
93062004983	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
93062004984	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
93062004985	GTPase CgtA; Reviewed; Region: obgE; PRK12297
93062004986	GTP1/OBG; Region: GTP1_OBG; pfam01018
93062004987	Obg GTPase; Region: Obg; cd01898
93062004988	G1 box; other site
93062004989	GTP/Mg2+ binding site [chemical binding]; other site
93062004990	Switch I region; other site
93062004991	G2 box; other site
93062004992	G3 box; other site
93062004993	Switch II region; other site
93062004994	G4 box; other site
93062004995	G5 box; other site
93062004996	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
93062004997	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
93062004998	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
93062004999	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
93062005000	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
93062005001	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
93062005002	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
93062005003	rod shape-determining protein MreC; Region: MreC; pfam04085
93062005004	hypothetical protein; Reviewed; Region: PRK00024
93062005005	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
93062005006	MPN+ (JAMM) motif; other site
93062005007	Zinc-binding site [ion binding]; other site
93062005008	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
93062005009	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
93062005010	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
93062005011	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
93062005012	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
93062005013	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
93062005014	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
93062005015	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
93062005016	active site
93062005017	HIGH motif; other site
93062005018	nucleotide binding site [chemical binding]; other site
93062005019	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
93062005020	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
93062005021	active site
93062005022	KMSKS motif; other site
93062005023	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
93062005024	tRNA binding surface [nucleotide binding]; other site
93062005025	anticodon binding site; other site
93062005026	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
93062005027	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
93062005028	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
93062005029	Putative ammonia monooxygenase; Region: AmoA; pfam05145
93062005030	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
93062005031	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
93062005032	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
93062005033	inhibitor-cofactor binding pocket; inhibition site
93062005034	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062005035	catalytic residue [active]
93062005036	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
93062005037	dimer interface [polypeptide binding]; other site
93062005038	active site
93062005039	Schiff base residues; other site
93062005040	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
93062005041	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
93062005042	active site
93062005043	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
93062005044	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
93062005045	domain interfaces; other site
93062005046	active site
93062005047	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
93062005048	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
93062005049	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
93062005050	tRNA; other site
93062005051	putative tRNA binding site [nucleotide binding]; other site
93062005052	putative NADP binding site [chemical binding]; other site
93062005053	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
93062005054	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
93062005055	G1 box; other site
93062005056	GTP/Mg2+ binding site [chemical binding]; other site
93062005057	Switch I region; other site
93062005058	G2 box; other site
93062005059	G3 box; other site
93062005060	Switch II region; other site
93062005061	G4 box; other site
93062005062	G5 box; other site
93062005063	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
93062005064	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
93062005065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062005066	Walker A motif; other site
93062005067	ATP binding site [chemical binding]; other site
93062005068	Walker B motif; other site
93062005069	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
93062005070	trigger factor; Provisional; Region: tig; PRK01490
93062005071	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
93062005072	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
93062005073	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
93062005074	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
93062005075	23S rRNA binding site [nucleotide binding]; other site
93062005076	L21 binding site [polypeptide binding]; other site
93062005077	L13 binding site [polypeptide binding]; other site
93062005078	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
93062005079	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
93062005080	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
93062005081	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
93062005082	lysine transporter; Provisional; Region: PRK10836
93062005083	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
93062005084	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
93062005085	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
93062005086	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
93062005087	active site
93062005088	dimer interface [polypeptide binding]; other site
93062005089	motif 1; other site
93062005090	motif 2; other site
93062005091	motif 3; other site
93062005092	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
93062005093	anticodon binding site; other site
93062005094	primosomal protein DnaI; Reviewed; Region: PRK08939
93062005095	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
93062005096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062005097	Walker A motif; other site
93062005098	ATP binding site [chemical binding]; other site
93062005099	Walker B motif; other site
93062005100	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
93062005101	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
93062005102	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
93062005103	ATP cone domain; Region: ATP-cone; pfam03477
93062005104	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
93062005105	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
93062005106	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
93062005107	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
93062005108	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
93062005109	CoA-binding site [chemical binding]; other site
93062005110	ATP-binding [chemical binding]; other site
93062005111	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
93062005112	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
93062005113	DNA binding site [nucleotide binding]
93062005114	catalytic residue [active]
93062005115	H2TH interface [polypeptide binding]; other site
93062005116	putative catalytic residues [active]
93062005117	turnover-facilitating residue; other site
93062005118	intercalation triad [nucleotide binding]; other site
93062005119	8OG recognition residue [nucleotide binding]; other site
93062005120	putative reading head residues; other site
93062005121	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
93062005122	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
93062005123	DNA polymerase I; Provisional; Region: PRK05755
93062005124	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
93062005125	active site
93062005126	metal binding site 1 [ion binding]; metal-binding site
93062005127	putative 5' ssDNA interaction site; other site
93062005128	metal binding site 3; metal-binding site
93062005129	metal binding site 2 [ion binding]; metal-binding site
93062005130	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
93062005131	putative DNA binding site [nucleotide binding]; other site
93062005132	putative metal binding site [ion binding]; other site
93062005133	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
93062005134	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
93062005135	active site
93062005136	DNA binding site [nucleotide binding]
93062005137	catalytic site [active]
93062005138	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
93062005139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062005140	dimer interface [polypeptide binding]; other site
93062005141	phosphorylation site [posttranslational modification]
93062005142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062005143	ATP binding site [chemical binding]; other site
93062005144	Mg2+ binding site [ion binding]; other site
93062005145	G-X-G motif; other site
93062005146	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062005147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062005148	active site
93062005149	phosphorylation site [posttranslational modification]
93062005150	intermolecular recognition site; other site
93062005151	dimerization interface [polypeptide binding]; other site
93062005152	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062005153	DNA binding site [nucleotide binding]
93062005154	isocitrate dehydrogenase; Reviewed; Region: PRK07006
93062005155	isocitrate dehydrogenase; Validated; Region: PRK07362
93062005156	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
93062005157	dimer interface [polypeptide binding]; other site
93062005158	Citrate synthase; Region: Citrate_synt; pfam00285
93062005159	active site
93062005160	citrylCoA binding site [chemical binding]; other site
93062005161	oxalacetate/citrate binding site [chemical binding]; other site
93062005162	coenzyme A binding site [chemical binding]; other site
93062005163	catalytic triad [active]
93062005164	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
93062005165	pyruvate kinase; Provisional; Region: PRK06354
93062005166	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
93062005167	domain interfaces; other site
93062005168	active site
93062005169	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
93062005170	6-phosphofructokinase; Provisional; Region: PRK03202
93062005171	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
93062005172	active site
93062005173	ADP/pyrophosphate binding site [chemical binding]; other site
93062005174	dimerization interface [polypeptide binding]; other site
93062005175	allosteric effector site; other site
93062005176	fructose-1,6-bisphosphate binding site; other site
93062005177	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
93062005178	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
93062005179	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
93062005180	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
93062005181	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
93062005182	Malic enzyme, N-terminal domain; Region: malic; pfam00390
93062005183	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
93062005184	putative NAD(P) binding site [chemical binding]; other site
93062005185	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
93062005186	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
93062005187	active site
93062005188	PHP Thumb interface [polypeptide binding]; other site
93062005189	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
93062005190	generic binding surface I; other site
93062005191	generic binding surface II; other site
93062005192	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
93062005193	DHH family; Region: DHH; pfam01368
93062005194	DHHA1 domain; Region: DHHA1; pfam02272
93062005195	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
93062005196	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
93062005197	DNA-binding site [nucleotide binding]; DNA binding site
93062005198	DRTGG domain; Region: DRTGG; pfam07085
93062005199	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
93062005200	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
93062005201	active site 2 [active]
93062005202	active site 1 [active]
93062005203	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
93062005204	Ligand Binding Site [chemical binding]; other site
93062005205	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
93062005206	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
93062005207	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
93062005208	active site
93062005209	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
93062005210	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
93062005211	hexamer interface [polypeptide binding]; other site
93062005212	ligand binding site [chemical binding]; other site
93062005213	putative active site [active]
93062005214	NAD(P) binding site [chemical binding]; other site
93062005215	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
93062005216	Ligand Binding Site [chemical binding]; other site
93062005217	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
93062005218	propionate/acetate kinase; Provisional; Region: PRK12379
93062005219	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
93062005220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062005221	S-adenosylmethionine binding site [chemical binding]; other site
93062005222	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
93062005223	dimer interface [polypeptide binding]; other site
93062005224	catalytic triad [active]
93062005225	peroxidatic and resolving cysteines [active]
93062005226	hypothetical protein; Provisional; Region: PRK10621
93062005227	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
93062005228	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
93062005229	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
93062005230	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
93062005231	Ligand Binding Site [chemical binding]; other site
93062005232	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
93062005233	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
93062005234	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062005235	catalytic residue [active]
93062005236	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
93062005237	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
93062005238	GAF domain; Region: GAF_2; pfam13185
93062005239	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
93062005240	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
93062005241	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062005242	RNA binding surface [nucleotide binding]; other site
93062005243	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
93062005244	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
93062005245	active site
93062005246	catalytic site [active]
93062005247	OsmC-like protein; Region: OsmC; cl00767
93062005248	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
93062005249	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062005250	catalytic residue [active]
93062005251	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
93062005252	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
93062005253	ligand binding site [chemical binding]; other site
93062005254	NAD binding site [chemical binding]; other site
93062005255	dimerization interface [polypeptide binding]; other site
93062005256	catalytic site [active]
93062005257	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
93062005258	putative L-serine binding site [chemical binding]; other site
93062005259	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
93062005260	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062005261	motif II; other site
93062005262	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
93062005263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062005264	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062005265	active site turn [active]
93062005266	phosphorylation site [posttranslational modification]
93062005267	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
93062005268	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
93062005269	putative acyl-acceptor binding pocket; other site
93062005270	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
93062005271	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
93062005272	protein binding site [polypeptide binding]; other site
93062005273	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
93062005274	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
93062005275	active site
93062005276	HIGH motif; other site
93062005277	dimer interface [polypeptide binding]; other site
93062005278	KMSKS motif; other site
93062005279	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062005280	RNA binding surface [nucleotide binding]; other site
93062005281	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
93062005282	Transglycosylase; Region: Transgly; pfam00912
93062005283	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
93062005284	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
93062005285	NEAr Transporter domain; Region: NEAT; smart00725
93062005286	NEAr Transporter domain; Region: NEAT; smart00725
93062005287	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
93062005288	heme-binding site [chemical binding]; other site
93062005289	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
93062005290	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
93062005291	Potassium binding sites [ion binding]; other site
93062005292	Cesium cation binding sites [ion binding]; other site
93062005293	acetyl-CoA synthetase; Provisional; Region: PRK04319
93062005294	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
93062005295	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
93062005296	active site
93062005297	acyl-activating enzyme (AAE) consensus motif; other site
93062005298	putative CoA binding site [chemical binding]; other site
93062005299	AMP binding site [chemical binding]; other site
93062005300	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
93062005301	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
93062005302	active site
93062005303	Zn binding site [ion binding]; other site
93062005304	catabolite control protein A; Region: ccpA; TIGR01481
93062005305	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
93062005306	DNA binding site [nucleotide binding]
93062005307	domain linker motif; other site
93062005308	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
93062005309	dimerization interface [polypeptide binding]; other site
93062005310	effector binding site; other site
93062005311	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
93062005312	Chorismate mutase type II; Region: CM_2; cl00693
93062005313	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
93062005314	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
93062005315	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
93062005316	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
93062005317	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
93062005318	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
93062005319	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
93062005320	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
93062005321	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
93062005322	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
93062005323	putative tRNA-binding site [nucleotide binding]; other site
93062005324	hypothetical protein; Provisional; Region: PRK13668
93062005325	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
93062005326	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
93062005327	catalytic residues [active]
93062005328	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
93062005329	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
93062005330	oligomer interface [polypeptide binding]; other site
93062005331	active site
93062005332	metal binding site [ion binding]; metal-binding site
93062005333	Predicted small secreted protein [Function unknown]; Region: COG5584
93062005334	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
93062005335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062005336	S-adenosylmethionine binding site [chemical binding]; other site
93062005337	Phosphotransferase enzyme family; Region: APH; pfam01636
93062005338	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
93062005339	active site
93062005340	substrate binding site [chemical binding]; other site
93062005341	ATP binding site [chemical binding]; other site
93062005342	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
93062005343	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
93062005344	homodimer interface [polypeptide binding]; other site
93062005345	substrate-cofactor binding pocket; other site
93062005346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062005347	catalytic residue [active]
93062005348	dipeptidase PepV; Reviewed; Region: PRK07318
93062005349	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
93062005350	active site
93062005351	metal binding site [ion binding]; metal-binding site
93062005352	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
93062005353	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
93062005354	RNA binding surface [nucleotide binding]; other site
93062005355	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
93062005356	active site
93062005357	uracil binding [chemical binding]; other site
93062005358	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
93062005359	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
93062005360	HI0933-like protein; Region: HI0933_like; pfam03486
93062005361	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062005362	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
93062005363	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005364	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005365	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005366	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005367	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005368	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005369	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005370	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005371	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005372	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005373	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005374	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005375	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005376	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005377	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062005378	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
93062005379	active site residue [active]
93062005380	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
93062005381	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
93062005382	HIGH motif; other site
93062005383	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
93062005384	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
93062005385	active site
93062005386	KMSKS motif; other site
93062005387	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
93062005388	tRNA binding surface [nucleotide binding]; other site
93062005389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062005390	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062005391	putative substrate translocation pore; other site
93062005392	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
93062005393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062005394	S-adenosylmethionine binding site [chemical binding]; other site
93062005395	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062005396	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
93062005397	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
93062005398	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
93062005399	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
93062005400	homopentamer interface [polypeptide binding]; other site
93062005401	active site
93062005402	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
93062005403	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
93062005404	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
93062005405	dimerization interface [polypeptide binding]; other site
93062005406	active site
93062005407	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
93062005408	Lumazine binding domain; Region: Lum_binding; pfam00677
93062005409	Lumazine binding domain; Region: Lum_binding; pfam00677
93062005410	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
93062005411	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
93062005412	catalytic motif [active]
93062005413	Zn binding site [ion binding]; other site
93062005414	RibD C-terminal domain; Region: RibD_C; cl17279
93062005415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
93062005416	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
93062005417	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
93062005418	dimerization interface [polypeptide binding]; other site
93062005419	putative DNA binding site [nucleotide binding]; other site
93062005420	putative Zn2+ binding site [ion binding]; other site
93062005421	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
93062005422	arsenical pump membrane protein; Provisional; Region: PRK15445
93062005423	transmembrane helices; other site
93062005424	Low molecular weight phosphatase family; Region: LMWPc; cd00115
93062005425	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
93062005426	active site
93062005427	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
93062005428	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
93062005429	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
93062005430	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
93062005431	DNA binding residues [nucleotide binding]
93062005432	CAAX protease self-immunity; Region: Abi; pfam02517
93062005433	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
93062005434	active site
93062005435	intersubunit interactions; other site
93062005436	catalytic residue [active]
93062005437	camphor resistance protein CrcB; Provisional; Region: PRK14201
93062005438	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
93062005439	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
93062005440	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
93062005441	active site
93062005442	catalytic tetrad [active]
93062005443	S-adenosylmethionine synthetase; Validated; Region: PRK05250
93062005444	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
93062005445	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
93062005446	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
93062005447	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
93062005448	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
93062005449	active site
93062005450	substrate-binding site [chemical binding]; other site
93062005451	metal-binding site [ion binding]
93062005452	ATP binding site [chemical binding]; other site
93062005453	Transposase IS200 like; Region: Y1_Tnp; pfam01797
93062005454	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
93062005455	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
93062005456	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
93062005457	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
93062005458	nudix motif; other site
93062005459	Haemolytic domain; Region: Haemolytic; pfam01809
93062005460	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
93062005461	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
93062005462	metal binding site [ion binding]; metal-binding site
93062005463	substrate binding pocket [chemical binding]; other site
93062005464	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
93062005465	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
93062005466	acyl-activating enzyme (AAE) consensus motif; other site
93062005467	putative AMP binding site [chemical binding]; other site
93062005468	putative active site [active]
93062005469	putative CoA binding site [chemical binding]; other site
93062005470	Excalibur calcium-binding domain; Region: Excalibur; smart00894
93062005471	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
93062005472	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
93062005473	Domain of unknown function (DUF955); Region: DUF955; pfam06114
93062005474	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
93062005475	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
93062005476	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
93062005477	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
93062005478	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
93062005479	HsdM N-terminal domain; Region: HsdM_N; pfam12161
93062005480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062005481	S-adenosylmethionine binding site [chemical binding]; other site
93062005482	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062005483	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
93062005484	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062005485	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
93062005486	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062005487	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
93062005488	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062005489	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062005490	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
93062005491	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
93062005492	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
93062005493	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
93062005494	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
93062005495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062005496	Walker A/P-loop; other site
93062005497	ATP binding site [chemical binding]; other site
93062005498	Q-loop/lid; other site
93062005499	ABC transporter signature motif; other site
93062005500	Walker B; other site
93062005501	D-loop; other site
93062005502	H-loop/switch region; other site
93062005503	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
93062005504	active site
93062005505	catalytic triad [active]
93062005506	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
93062005507	Flavoprotein; Region: Flavoprotein; pfam02441
93062005508	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
93062005509	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
93062005510	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
93062005511	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
93062005512	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
93062005513	Transposase; Region: DDE_Tnp_ISL3; pfam01610
93062005514	beta-channel forming cytolysin; Region: hlyII; TIGR01002
93062005515	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
93062005516	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
93062005517	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
93062005518	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
93062005519	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
93062005520	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
93062005521	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
93062005522	ferrochelatase; Provisional; Region: PRK12435
93062005523	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
93062005524	C-terminal domain interface [polypeptide binding]; other site
93062005525	active site
93062005526	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
93062005527	active site
93062005528	N-terminal domain interface [polypeptide binding]; other site
93062005529	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
93062005530	substrate binding site [chemical binding]; other site
93062005531	active site
93062005532	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
93062005533	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
93062005534	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
93062005535	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
93062005536	Walker A/P-loop; other site
93062005537	ATP binding site [chemical binding]; other site
93062005538	Q-loop/lid; other site
93062005539	ABC transporter signature motif; other site
93062005540	Walker B; other site
93062005541	D-loop; other site
93062005542	H-loop/switch region; other site
93062005543	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
93062005544	HIT family signature motif; other site
93062005545	catalytic residue [active]
93062005546	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
93062005547	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
93062005548	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
93062005549	SurA N-terminal domain; Region: SurA_N_3; cl07813
93062005550	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
93062005551	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
93062005552	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
93062005553	generic binding surface II; other site
93062005554	generic binding surface I; other site
93062005555	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
93062005556	Zn2+ binding site [ion binding]; other site
93062005557	Mg2+ binding site [ion binding]; other site
93062005558	Uncharacterized conserved protein [Function unknown]; Region: COG4717
93062005559	P-loop containing region of AAA domain; Region: AAA_29; cl17516
93062005560	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
93062005561	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
93062005562	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
93062005563	active site
93062005564	metal binding site [ion binding]; metal-binding site
93062005565	DNA binding site [nucleotide binding]
93062005566	hypothetical protein; Provisional; Region: PRK13676
93062005567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
93062005568	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
93062005569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062005570	non-specific DNA binding site [nucleotide binding]; other site
93062005571	salt bridge; other site
93062005572	sequence-specific DNA binding site [nucleotide binding]; other site
93062005573	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
93062005574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062005575	active site
93062005576	phosphorylation site [posttranslational modification]
93062005577	intermolecular recognition site; other site
93062005578	dimerization interface [polypeptide binding]; other site
93062005579	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
93062005580	DNA binding residues [nucleotide binding]
93062005581	dimerization interface [polypeptide binding]; other site
93062005582	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
93062005583	GAF domain; Region: GAF_3; pfam13492
93062005584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
93062005585	Histidine kinase; Region: HisKA_3; pfam07730
93062005586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062005587	ATP binding site [chemical binding]; other site
93062005588	Mg2+ binding site [ion binding]; other site
93062005589	G-X-G motif; other site
93062005590	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
93062005591	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
93062005592	active site
93062005593	fumarate hydratase; Reviewed; Region: fumC; PRK00485
93062005594	Class II fumarases; Region: Fumarase_classII; cd01362
93062005595	active site
93062005596	tetramer interface [polypeptide binding]; other site
93062005597	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
93062005598	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
93062005599	active site
93062005600	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
93062005601	epoxyqueuosine reductase; Region: TIGR00276
93062005602	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
93062005603	HEAT repeats; Region: HEAT_2; pfam13646
93062005604	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
93062005605	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
93062005606	Walker A/P-loop; other site
93062005607	ATP binding site [chemical binding]; other site
93062005608	Q-loop/lid; other site
93062005609	ABC transporter signature motif; other site
93062005610	Walker B; other site
93062005611	D-loop; other site
93062005612	H-loop/switch region; other site
93062005613	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
93062005614	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
93062005615	substrate binding pocket [chemical binding]; other site
93062005616	membrane-bound complex binding site; other site
93062005617	hinge residues; other site
93062005618	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
93062005619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062005620	dimer interface [polypeptide binding]; other site
93062005621	conserved gate region; other site
93062005622	putative PBP binding loops; other site
93062005623	ABC-ATPase subunit interface; other site
93062005624	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
93062005625	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
93062005626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
93062005627	Transposase; Region: DDE_Tnp_ISL3; pfam01610
93062005628	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
93062005629	metal binding site 2 [ion binding]; metal-binding site
93062005630	putative DNA binding helix; other site
93062005631	metal binding site 1 [ion binding]; metal-binding site
93062005632	dimer interface [polypeptide binding]; other site
93062005633	structural Zn2+ binding site [ion binding]; other site
93062005634	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
93062005635	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
93062005636	putative ligand binding site [chemical binding]; other site
93062005637	NAD binding site [chemical binding]; other site
93062005638	catalytic site [active]
93062005639	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
93062005640	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
93062005641	catalytic triad [active]
93062005642	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
93062005643	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
93062005644	inhibitor-cofactor binding pocket; inhibition site
93062005645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062005646	catalytic residue [active]
93062005647	Predicted membrane protein [Function unknown]; Region: COG4129
93062005648	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
93062005649	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
93062005650	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
93062005651	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
93062005652	Walker A/P-loop; other site
93062005653	ATP binding site [chemical binding]; other site
93062005654	Q-loop/lid; other site
93062005655	ABC transporter signature motif; other site
93062005656	Walker B; other site
93062005657	D-loop; other site
93062005658	H-loop/switch region; other site
93062005659	hypothetical protein; Provisional; Region: PRK13662
93062005660	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
93062005661	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
93062005662	minor groove reading motif; other site
93062005663	helix-hairpin-helix signature motif; other site
93062005664	substrate binding pocket [chemical binding]; other site
93062005665	active site
93062005666	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
93062005667	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
93062005668	DNA binding and oxoG recognition site [nucleotide binding]
93062005669	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
93062005670	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
93062005671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062005672	Walker A/P-loop; other site
93062005673	ATP binding site [chemical binding]; other site
93062005674	Q-loop/lid; other site
93062005675	ABC transporter signature motif; other site
93062005676	Walker B; other site
93062005677	H-loop/switch region; other site
93062005678	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
93062005679	recombination regulator RecX; Provisional; Region: recX; PRK14135
93062005680	glycosyltransferase; Provisional; Region: PRK13481
93062005681	Transglycosylase; Region: Transgly; pfam00912
93062005682	intracellular protease, PfpI family; Region: PfpI; TIGR01382
93062005683	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
93062005684	proposed catalytic triad [active]
93062005685	conserved cys residue [active]
93062005686	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
93062005687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062005688	FeS/SAM binding site; other site
93062005689	YfkB-like domain; Region: YfkB; pfam08756
93062005690	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
93062005691	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
93062005692	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
93062005693	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
93062005694	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
93062005695	Low molecular weight phosphatase family; Region: LMWPc; cd00115
93062005696	active site
93062005697	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
93062005698	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
93062005699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062005700	active site
93062005701	phosphorylation site [posttranslational modification]
93062005702	intermolecular recognition site; other site
93062005703	dimerization interface [polypeptide binding]; other site
93062005704	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
93062005705	DNA binding residues [nucleotide binding]
93062005706	dimerization interface [polypeptide binding]; other site
93062005707	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
93062005708	Histidine kinase; Region: HisKA_3; pfam07730
93062005709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062005710	ATP binding site [chemical binding]; other site
93062005711	Mg2+ binding site [ion binding]; other site
93062005712	G-X-G motif; other site
93062005713	Predicted membrane protein [Function unknown]; Region: COG4758
93062005714	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
93062005715	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
93062005716	active site
93062005717	Predicted membrane protein [Function unknown]; Region: COG4129
93062005718	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
93062005719	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
93062005720	catalytic triad [active]
93062005721	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
93062005722	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
93062005723	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
93062005724	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
93062005725	Ferritin-like domain; Region: Ferritin; pfam00210
93062005726	ferroxidase diiron center [ion binding]; other site
93062005727	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
93062005728	active site
93062005729	catalytic site [active]
93062005730	substrate binding site [chemical binding]; other site
93062005731	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
93062005732	active site
93062005733	DNA polymerase IV; Validated; Region: PRK02406
93062005734	DNA binding site [nucleotide binding]
93062005735	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
93062005736	TRAM domain; Region: TRAM; cl01282
93062005737	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
93062005738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062005739	S-adenosylmethionine binding site [chemical binding]; other site
93062005740	putative lipid kinase; Reviewed; Region: PRK13337
93062005741	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
93062005742	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
93062005743	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
93062005744	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
93062005745	GatB domain; Region: GatB_Yqey; pfam02637
93062005746	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
93062005747	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
93062005748	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
93062005749	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
93062005750	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
93062005751	Na binding site [ion binding]; other site
93062005752	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
93062005753	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
93062005754	putative dimer interface [polypeptide binding]; other site
93062005755	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
93062005756	putative dimer interface [polypeptide binding]; other site
93062005757	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
93062005758	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
93062005759	nucleotide binding pocket [chemical binding]; other site
93062005760	K-X-D-G motif; other site
93062005761	catalytic site [active]
93062005762	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
93062005763	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
93062005764	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
93062005765	Dimer interface [polypeptide binding]; other site
93062005766	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
93062005767	Part of AAA domain; Region: AAA_19; pfam13245
93062005768	Family description; Region: UvrD_C_2; pfam13538
93062005769	PcrB family; Region: PcrB; pfam01884
93062005770	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
93062005771	substrate binding site [chemical binding]; other site
93062005772	putative active site [active]
93062005773	dimer interface [polypeptide binding]; other site
93062005774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
93062005775	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
93062005776	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
93062005777	tetramer interface [polypeptide binding]; other site
93062005778	active site
93062005779	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
93062005780	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
93062005781	Staphostatin A; Region: Staphostatin_A; pfam09022
93062005782	NETI protein; Region: NETI; pfam14044
93062005783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
93062005784	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
93062005785	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
93062005786	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
93062005787	homodimer interface [polypeptide binding]; other site
93062005788	NAD binding pocket [chemical binding]; other site
93062005789	ATP binding pocket [chemical binding]; other site
93062005790	Mg binding site [ion binding]; other site
93062005791	active-site loop [active]
93062005792	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
93062005793	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
93062005794	active site
93062005795	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
93062005796	active site
93062005797	dimer interface [polypeptide binding]; other site
93062005798	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
93062005799	Prephenate dehydratase; Region: PDT; pfam00800
93062005800	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
93062005801	putative L-Phe binding site [chemical binding]; other site
93062005802	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
93062005803	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
93062005804	transmembrane helices; other site
93062005805	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
93062005806	Isochorismatase family; Region: Isochorismatase; pfam00857
93062005807	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
93062005808	catalytic triad [active]
93062005809	conserved cis-peptide bond; other site
93062005810	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
93062005811	DHH family; Region: DHH; pfam01368
93062005812	DHHA2 domain; Region: DHHA2; pfam02833
93062005813	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
93062005814	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
93062005815	NAD(P) binding site [chemical binding]; other site
93062005816	catalytic residues [active]
93062005817	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
93062005818	YolD-like protein; Region: YolD; pfam08863
93062005819	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
93062005820	active site
93062005821	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
93062005822	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
93062005823	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
93062005824	Bacterial PH domain; Region: DUF304; cl01348
93062005825	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
93062005826	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
93062005827	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
93062005828	Walker A/P-loop; other site
93062005829	ATP binding site [chemical binding]; other site
93062005830	Q-loop/lid; other site
93062005831	ABC transporter signature motif; other site
93062005832	Walker B; other site
93062005833	D-loop; other site
93062005834	H-loop/switch region; other site
93062005835	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
93062005836	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
93062005837	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
93062005838	Walker A/P-loop; other site
93062005839	ATP binding site [chemical binding]; other site
93062005840	Q-loop/lid; other site
93062005841	ABC transporter signature motif; other site
93062005842	Walker B; other site
93062005843	D-loop; other site
93062005844	H-loop/switch region; other site
93062005845	Predicted transcriptional regulators [Transcription]; Region: COG1725
93062005846	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062005847	DNA-binding site [nucleotide binding]; DNA binding site
93062005848	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
93062005849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062005850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062005851	homodimer interface [polypeptide binding]; other site
93062005852	catalytic residue [active]
93062005853	MAP domain; Region: MAP; pfam03642
93062005854	MAP domain; Region: MAP; pfam03642
93062005855	MAP domain; Region: MAP; pfam03642
93062005856	MAP domain; Region: MAP; pfam03642
93062005857	MAP domain; Region: MAP; pfam03642
93062005858	MAP domain; Region: MAP; pfam03642
93062005859	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
93062005860	putative catalytic site [active]
93062005861	metal binding site A [ion binding]; metal-binding site
93062005862	phosphate binding site [ion binding]; other site
93062005863	metal binding site C [ion binding]; metal-binding site
93062005864	metal binding site B [ion binding]; metal-binding site
93062005865	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
93062005866	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
93062005867	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
93062005868	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
93062005869	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
93062005870	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
93062005871	putative ligand binding residues [chemical binding]; other site
93062005872	Cation transport protein; Region: TrkH; cl17365
93062005873	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
93062005874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062005875	Coenzyme A binding pocket [chemical binding]; other site
93062005876	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
93062005877	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
93062005878	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
93062005879	ring oligomerisation interface [polypeptide binding]; other site
93062005880	ATP/Mg binding site [chemical binding]; other site
93062005881	stacking interactions; other site
93062005882	hinge regions; other site
93062005883	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
93062005884	oligomerisation interface [polypeptide binding]; other site
93062005885	mobile loop; other site
93062005886	roof hairpin; other site
93062005887	CAAX protease self-immunity; Region: Abi; pfam02517
93062005888	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
93062005889	dimer interface [polypeptide binding]; other site
93062005890	FMN binding site [chemical binding]; other site
93062005891	Predicted amidohydrolase [General function prediction only]; Region: COG0388
93062005892	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
93062005893	putative active site [active]
93062005894	catalytic triad [active]
93062005895	putative dimer interface [polypeptide binding]; other site
93062005896	delta-hemolysin; Provisional; Region: PRK14752
93062005897	Accessory gene regulator B; Region: AgrB; smart00793
93062005898	Staphylococcal AgrD protein; Region: AgrD; smart00794
93062005899	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
93062005900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062005901	Mg2+ binding site [ion binding]; other site
93062005902	G-X-G motif; other site
93062005903	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
93062005904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062005905	active site
93062005906	phosphorylation site [posttranslational modification]
93062005907	intermolecular recognition site; other site
93062005908	dimerization interface [polypeptide binding]; other site
93062005909	LytTr DNA-binding domain; Region: LytTR; pfam04397
93062005910	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
93062005911	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
93062005912	putative substrate binding site [chemical binding]; other site
93062005913	putative ATP binding site [chemical binding]; other site
93062005914	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
93062005915	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
93062005916	substrate binding [chemical binding]; other site
93062005917	active site
93062005918	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
93062005919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
93062005920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
93062005921	DNA binding site [nucleotide binding]
93062005922	domain linker motif; other site
93062005923	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
93062005924	dimerization interface [polypeptide binding]; other site
93062005925	ligand binding site [chemical binding]; other site
93062005926	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
93062005927	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
93062005928	CPxP  motif; other site
93062005929	Predicted transporter component [General function prediction only]; Region: COG2391
93062005930	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
93062005931	Sulphur transport; Region: Sulf_transp; pfam04143
93062005932	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
93062005933	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
93062005934	CoA binding domain; Region: CoA_binding; pfam02629
93062005935	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
93062005936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062005937	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062005938	ABC transporter; Region: ABC_tran_2; pfam12848
93062005939	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
93062005940	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
93062005941	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
93062005942	Walker A/P-loop; other site
93062005943	ATP binding site [chemical binding]; other site
93062005944	Q-loop/lid; other site
93062005945	ABC transporter signature motif; other site
93062005946	Walker B; other site
93062005947	D-loop; other site
93062005948	H-loop/switch region; other site
93062005949	UGMP family protein; Validated; Region: PRK09604
93062005950	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
93062005951	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
93062005952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062005953	Coenzyme A binding pocket [chemical binding]; other site
93062005954	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
93062005955	Glycoprotease family; Region: Peptidase_M22; pfam00814
93062005956	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
93062005957	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
93062005958	6-phosphogluconate dehydratase; Region: edd; TIGR01196
93062005959	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
93062005960	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
93062005961	PYR/PP interface [polypeptide binding]; other site
93062005962	dimer interface [polypeptide binding]; other site
93062005963	TPP binding site [chemical binding]; other site
93062005964	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
93062005965	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
93062005966	TPP-binding site [chemical binding]; other site
93062005967	dimer interface [polypeptide binding]; other site
93062005968	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
93062005969	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
93062005970	ketol-acid reductoisomerase; Provisional; Region: PRK05479
93062005971	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
93062005972	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
93062005973	2-isopropylmalate synthase; Validated; Region: PRK00915
93062005974	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
93062005975	active site
93062005976	catalytic residues [active]
93062005977	metal binding site [ion binding]; metal-binding site
93062005978	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
93062005979	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
93062005980	tartrate dehydrogenase; Region: TTC; TIGR02089
93062005981	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
93062005982	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
93062005983	substrate binding site [chemical binding]; other site
93062005984	ligand binding site [chemical binding]; other site
93062005985	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
93062005986	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
93062005987	substrate binding site [chemical binding]; other site
93062005988	threonine dehydratase; Validated; Region: PRK08639
93062005989	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
93062005990	tetramer interface [polypeptide binding]; other site
93062005991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062005992	catalytic residue [active]
93062005993	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
93062005994	putative Ile/Val binding site [chemical binding]; other site
93062005995	hypothetical protein; Provisional; Region: PRK04351
93062005996	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
93062005997	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
93062005998	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
93062005999	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
93062006000	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
93062006001	RNA binding site [nucleotide binding]; other site
93062006002	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
93062006003	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
93062006004	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
93062006005	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
93062006006	DNA binding residues [nucleotide binding]
93062006007	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
93062006008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062006009	ATP binding site [chemical binding]; other site
93062006010	Mg2+ binding site [ion binding]; other site
93062006011	G-X-G motif; other site
93062006012	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
93062006013	anti sigma factor interaction site; other site
93062006014	regulatory phosphorylation site [posttranslational modification]; other site
93062006015	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
93062006016	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
93062006017	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
93062006018	PemK-like protein; Region: PemK; pfam02452
93062006019	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
93062006020	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
93062006021	active site
93062006022	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
93062006023	dimer interface [polypeptide binding]; other site
93062006024	substrate binding site [chemical binding]; other site
93062006025	catalytic residues [active]
93062006026	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
93062006027	Uncharacterized conserved protein [Function unknown]; Region: COG3402
93062006028	Predicted membrane protein [Function unknown]; Region: COG3428
93062006029	Bacterial PH domain; Region: DUF304; pfam03703
93062006030	Bacterial PH domain; Region: DUF304; pfam03703
93062006031	Bacterial PH domain; Region: DUF304; cl01348
93062006032	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
93062006033	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
93062006034	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
93062006035	Soluble P-type ATPase [General function prediction only]; Region: COG4087
93062006036	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
93062006037	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
93062006038	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
93062006039	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
93062006040	Ligand Binding Site [chemical binding]; other site
93062006041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062006042	dimer interface [polypeptide binding]; other site
93062006043	phosphorylation site [posttranslational modification]
93062006044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062006045	ATP binding site [chemical binding]; other site
93062006046	Mg2+ binding site [ion binding]; other site
93062006047	G-X-G motif; other site
93062006048	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062006049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062006050	active site
93062006051	phosphorylation site [posttranslational modification]
93062006052	intermolecular recognition site; other site
93062006053	dimerization interface [polypeptide binding]; other site
93062006054	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062006055	DNA binding site [nucleotide binding]
93062006056	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
93062006057	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
93062006058	ATP binding site [chemical binding]; other site
93062006059	Mg++ binding site [ion binding]; other site
93062006060	motif III; other site
93062006061	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062006062	nucleotide binding region [chemical binding]; other site
93062006063	ATP-binding site [chemical binding]; other site
93062006064	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
93062006065	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
93062006066	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
93062006067	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
93062006068	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
93062006069	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
93062006070	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
93062006071	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
93062006072	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
93062006073	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
93062006074	putative homodimer interface [polypeptide binding]; other site
93062006075	putative homotetramer interface [polypeptide binding]; other site
93062006076	allosteric switch controlling residues; other site
93062006077	putative metal binding site [ion binding]; other site
93062006078	putative homodimer-homodimer interface [polypeptide binding]; other site
93062006079	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
93062006080	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
93062006081	putative active site [active]
93062006082	catalytic site [active]
93062006083	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
93062006084	putative active site [active]
93062006085	catalytic site [active]
93062006086	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
93062006087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
93062006088	Zn2+ binding site [ion binding]; other site
93062006089	Mg2+ binding site [ion binding]; other site
93062006090	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
93062006091	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
93062006092	thiamine phosphate binding site [chemical binding]; other site
93062006093	active site
93062006094	pyrophosphate binding site [ion binding]; other site
93062006095	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
93062006096	substrate binding site [chemical binding]; other site
93062006097	multimerization interface [polypeptide binding]; other site
93062006098	ATP binding site [chemical binding]; other site
93062006099	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
93062006100	dimer interface [polypeptide binding]; other site
93062006101	substrate binding site [chemical binding]; other site
93062006102	ATP binding site [chemical binding]; other site
93062006103	thiaminase II; Region: salvage_TenA; TIGR04306
93062006104	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
93062006105	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
93062006106	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
93062006107	dimer interface [polypeptide binding]; other site
93062006108	ssDNA binding site [nucleotide binding]; other site
93062006109	tetramer (dimer of dimers) interface [polypeptide binding]; other site
93062006110	YwpF-like protein; Region: YwpF; pfam14183
93062006111	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
93062006112	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
93062006113	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
93062006114	hinge; other site
93062006115	active site
93062006116	Predicted membrane protein [Function unknown]; Region: COG4836
93062006117	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
93062006118	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
93062006119	gamma subunit interface [polypeptide binding]; other site
93062006120	epsilon subunit interface [polypeptide binding]; other site
93062006121	LBP interface [polypeptide binding]; other site
93062006122	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
93062006123	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
93062006124	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
93062006125	alpha subunit interaction interface [polypeptide binding]; other site
93062006126	Walker A motif; other site
93062006127	ATP binding site [chemical binding]; other site
93062006128	Walker B motif; other site
93062006129	inhibitor binding site; inhibition site
93062006130	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
93062006131	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
93062006132	core domain interface [polypeptide binding]; other site
93062006133	delta subunit interface [polypeptide binding]; other site
93062006134	epsilon subunit interface [polypeptide binding]; other site
93062006135	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
93062006136	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
93062006137	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
93062006138	beta subunit interaction interface [polypeptide binding]; other site
93062006139	Walker A motif; other site
93062006140	ATP binding site [chemical binding]; other site
93062006141	Walker B motif; other site
93062006142	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
93062006143	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
93062006144	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
93062006145	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
93062006146	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
93062006147	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
93062006148	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
93062006149	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
93062006150	Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468
93062006151	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
93062006152	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
93062006153	active site
93062006154	homodimer interface [polypeptide binding]; other site
93062006155	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
93062006156	active site
93062006157	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
93062006158	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
93062006159	dimer interface [polypeptide binding]; other site
93062006160	active site
93062006161	glycine-pyridoxal phosphate binding site [chemical binding]; other site
93062006162	folate binding site [chemical binding]; other site
93062006163	hypothetical protein; Provisional; Region: PRK13690
93062006164	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
93062006165	Low molecular weight phosphatase family; Region: LMWPc; cd00115
93062006166	active site
93062006167	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
93062006168	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
93062006169	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
93062006170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062006171	S-adenosylmethionine binding site [chemical binding]; other site
93062006172	peptide chain release factor 1; Validated; Region: prfA; PRK00591
93062006173	This domain is found in peptide chain release factors; Region: PCRF; smart00937
93062006174	RF-1 domain; Region: RF-1; pfam00472
93062006175	thymidine kinase; Provisional; Region: PRK04296
93062006176	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
93062006177	transcription termination factor Rho; Provisional; Region: rho; PRK09376
93062006178	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
93062006179	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
93062006180	RNA binding site [nucleotide binding]; other site
93062006181	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
93062006182	multimer interface [polypeptide binding]; other site
93062006183	Walker A motif; other site
93062006184	ATP binding site [chemical binding]; other site
93062006185	Walker B motif; other site
93062006186	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
93062006187	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
93062006188	NAD binding site [chemical binding]; other site
93062006189	catalytic residues [active]
93062006190	Predicted transcriptional regulators [Transcription]; Region: COG1733
93062006191	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
93062006192	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
93062006193	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
93062006194	hinge; other site
93062006195	active site
93062006196	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
93062006197	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
93062006198	intersubunit interface [polypeptide binding]; other site
93062006199	active site
93062006200	zinc binding site [ion binding]; other site
93062006201	Na+ binding site [ion binding]; other site
93062006202	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
93062006203	CTP synthetase; Validated; Region: pyrG; PRK05380
93062006204	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
93062006205	Catalytic site [active]
93062006206	active site
93062006207	UTP binding site [chemical binding]; other site
93062006208	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
93062006209	active site
93062006210	putative oxyanion hole; other site
93062006211	catalytic triad [active]
93062006212	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
93062006213	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
93062006214	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062006215	Coenzyme A binding pocket [chemical binding]; other site
93062006216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
93062006217	Coenzyme A binding pocket [chemical binding]; other site
93062006218	pantothenate kinase; Provisional; Region: PRK13317
93062006219	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
93062006220	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
93062006221	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
93062006222	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
93062006223	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
93062006224	metal binding site [ion binding]; metal-binding site
93062006225	S-ribosylhomocysteinase; Provisional; Region: PRK02260
93062006226	Predicted membrane protein [Function unknown]; Region: COG4270
93062006227	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
93062006228	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
93062006229	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
93062006230	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
93062006231	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
93062006232	intersubunit interface [polypeptide binding]; other site
93062006233	active site
93062006234	catalytic residue [active]
93062006235	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
93062006236	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
93062006237	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
93062006238	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
93062006239	dimerization interface [polypeptide binding]; other site
93062006240	DPS ferroxidase diiron center [ion binding]; other site
93062006241	ion pore; other site
93062006242	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
93062006243	EVE domain; Region: EVE; cl00728
93062006244	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
93062006245	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
93062006246	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
93062006247	NADH(P)-binding; Region: NAD_binding_10; pfam13460
93062006248	NAD(P) binding site [chemical binding]; other site
93062006249	putative active site [active]
93062006250	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
93062006251	dimerization interface [polypeptide binding]; other site
93062006252	putative DNA binding site [nucleotide binding]; other site
93062006253	putative Zn2+ binding site [ion binding]; other site
93062006254	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
93062006255	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
93062006256	SAP domain; Region: SAP; pfam02037
93062006257	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
93062006258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062006259	active site
93062006260	motif I; other site
93062006261	motif II; other site
93062006262	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062006263	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
93062006264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062006265	Walker A/P-loop; other site
93062006266	ATP binding site [chemical binding]; other site
93062006267	Q-loop/lid; other site
93062006268	ABC transporter signature motif; other site
93062006269	Walker B; other site
93062006270	D-loop; other site
93062006271	H-loop/switch region; other site
93062006272	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
93062006273	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
93062006274	glutaminase active site [active]
93062006275	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
93062006276	dimer interface [polypeptide binding]; other site
93062006277	active site
93062006278	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
93062006279	dimer interface [polypeptide binding]; other site
93062006280	active site
93062006281	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
93062006282	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
93062006283	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
93062006284	active site
93062006285	P-loop; other site
93062006286	phosphorylation site [posttranslational modification]
93062006287	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
93062006288	HTH domain; Region: HTH_11; pfam08279
93062006289	Mga helix-turn-helix domain; Region: Mga; pfam05043
93062006290	PRD domain; Region: PRD; pfam00874
93062006291	PRD domain; Region: PRD; pfam00874
93062006292	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
93062006293	active site
93062006294	P-loop; other site
93062006295	phosphorylation site [posttranslational modification]
93062006296	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
93062006297	active site
93062006298	phosphorylation site [posttranslational modification]
93062006299	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062006300	active site
93062006301	phosphorylation site [posttranslational modification]
93062006302	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
93062006303	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
93062006304	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
93062006305	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062006306	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
93062006307	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062006308	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062006309	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062006310	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062006311	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062006312	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
93062006313	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
93062006314	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
93062006315	active site
93062006316	substrate binding site [chemical binding]; other site
93062006317	metal binding site [ion binding]; metal-binding site
93062006318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
93062006319	YbbR-like protein; Region: YbbR; pfam07949
93062006320	TIGR00159 family protein; Region: TIGR00159
93062006321	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
93062006322	Arginase family; Region: Arginase; cd09989
93062006323	active site
93062006324	Mn binding site [ion binding]; other site
93062006325	oligomer interface [polypeptide binding]; other site
93062006326	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
93062006327	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
93062006328	Walker A motif; other site
93062006329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062006331	putative substrate translocation pore; other site
93062006332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006333	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062006334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006335	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
93062006336	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
93062006337	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
93062006338	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
93062006339	substrate binding site; other site
93062006340	dimerization interface; other site
93062006341	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
93062006342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
93062006343	Nucleoside recognition; Region: Gate; pfam07670
93062006344	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
93062006345	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062006346	ABC-ATPase subunit  interface; other site
93062006347	dimer interface [polypeptide binding]; other site
93062006348	putative PBP binding regions; other site
93062006349	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
93062006350	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
93062006351	ABC-ATPase subunit  interface; other site
93062006352	dimer interface [polypeptide binding]; other site
93062006353	putative PBP binding regions; other site
93062006354	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
93062006355	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
93062006356	siderophore binding site; other site
93062006357	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
93062006358	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
93062006359	dimer interface [polypeptide binding]; other site
93062006360	active site
93062006361	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
93062006362	substrate binding site [chemical binding]; other site
93062006363	catalytic residue [active]
93062006364	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
93062006365	IucA / IucC family; Region: IucA_IucC; pfam04183
93062006366	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
93062006367	H+ Antiporter protein; Region: 2A0121; TIGR00900
93062006368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006369	putative substrate translocation pore; other site
93062006370	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
93062006371	IucA / IucC family; Region: IucA_IucC; pfam04183
93062006372	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
93062006373	Asp23 family; Region: Asp23; pfam03780
93062006374	Small integral membrane protein [Function unknown]; Region: COG5547
93062006375	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
93062006376	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
93062006377	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
93062006378	putative NAD(P) binding site [chemical binding]; other site
93062006379	dimer interface [polypeptide binding]; other site
93062006380	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
93062006381	Prostaglandin dehydrogenases; Region: PGDH; cd05288
93062006382	NAD(P) binding site [chemical binding]; other site
93062006383	substrate binding site [chemical binding]; other site
93062006384	dimer interface [polypeptide binding]; other site
93062006385	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
93062006386	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
93062006387	beta-galactosidase; Region: BGL; TIGR03356
93062006388	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
93062006389	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
93062006390	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
93062006391	active site
93062006392	P-loop; other site
93062006393	phosphorylation site [posttranslational modification]
93062006394	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
93062006395	methionine cluster; other site
93062006396	active site
93062006397	phosphorylation site [posttranslational modification]
93062006398	metal binding site [ion binding]; metal-binding site
93062006399	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
93062006400	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
93062006401	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
93062006402	putative substrate binding site [chemical binding]; other site
93062006403	putative ATP binding site [chemical binding]; other site
93062006404	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
93062006405	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
93062006406	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
93062006407	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
93062006408	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
93062006409	NAD-dependent deacetylase; Provisional; Region: PRK00481
93062006410	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
93062006411	NAD+ binding site [chemical binding]; other site
93062006412	substrate binding site [chemical binding]; other site
93062006413	putative Zn binding site [ion binding]; other site
93062006414	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
93062006415	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
93062006416	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
93062006417	active site
93062006418	catalytic tetrad [active]
93062006419	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
93062006420	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
93062006421	DNA binding residues [nucleotide binding]
93062006422	putative dimer interface [polypeptide binding]; other site
93062006423	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
93062006424	substrate binding site [chemical binding]; other site
93062006425	catalytic residues [active]
93062006426	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
93062006427	Peptidase family M23; Region: Peptidase_M23; pfam01551
93062006428	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
93062006429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
93062006430	active site
93062006431	motif I; other site
93062006432	motif II; other site
93062006433	MAP domain; Region: MAP; pfam03642
93062006434	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
93062006435	acetolactate synthase; Reviewed; Region: PRK08617
93062006436	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
93062006437	PYR/PP interface [polypeptide binding]; other site
93062006438	dimer interface [polypeptide binding]; other site
93062006439	TPP binding site [chemical binding]; other site
93062006440	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
93062006441	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
93062006442	TPP-binding site [chemical binding]; other site
93062006443	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
93062006444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062006445	Walker A motif; other site
93062006446	ATP binding site [chemical binding]; other site
93062006447	Walker B motif; other site
93062006448	arginine finger; other site
93062006449	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
93062006450	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
93062006451	23S rRNA interface [nucleotide binding]; other site
93062006452	L3 interface [polypeptide binding]; other site
93062006453	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
93062006454	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
93062006455	dimerization interface 3.5A [polypeptide binding]; other site
93062006456	active site
93062006457	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
93062006458	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
93062006459	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062006460	Walker A/P-loop; other site
93062006461	ATP binding site [chemical binding]; other site
93062006462	Q-loop/lid; other site
93062006463	ABC transporter signature motif; other site
93062006464	Walker B; other site
93062006465	D-loop; other site
93062006466	H-loop/switch region; other site
93062006467	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
93062006468	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062006469	Walker A/P-loop; other site
93062006470	ATP binding site [chemical binding]; other site
93062006471	Q-loop/lid; other site
93062006472	ABC transporter signature motif; other site
93062006473	Walker B; other site
93062006474	D-loop; other site
93062006475	H-loop/switch region; other site
93062006476	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
93062006477	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
93062006478	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
93062006479	alphaNTD homodimer interface [polypeptide binding]; other site
93062006480	alphaNTD - beta interaction site [polypeptide binding]; other site
93062006481	alphaNTD - beta' interaction site [polypeptide binding]; other site
93062006482	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
93062006483	30S ribosomal protein S11; Validated; Region: PRK05309
93062006484	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
93062006485	30S ribosomal protein S13; Region: bact_S13; TIGR03631
93062006486	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
93062006487	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
93062006488	rRNA binding site [nucleotide binding]; other site
93062006489	predicted 30S ribosome binding site; other site
93062006490	adenylate kinase; Reviewed; Region: adk; PRK00279
93062006491	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
93062006492	AMP-binding site [chemical binding]; other site
93062006493	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
93062006494	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
93062006495	SecY translocase; Region: SecY; pfam00344
93062006496	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
93062006497	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
93062006498	23S rRNA binding site [nucleotide binding]; other site
93062006499	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
93062006500	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
93062006501	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
93062006502	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
93062006503	5S rRNA interface [nucleotide binding]; other site
93062006504	L27 interface [polypeptide binding]; other site
93062006505	23S rRNA interface [nucleotide binding]; other site
93062006506	L5 interface [polypeptide binding]; other site
93062006507	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
93062006508	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
93062006509	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
93062006510	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
93062006511	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
93062006512	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
93062006513	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
93062006514	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
93062006515	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
93062006516	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
93062006517	RNA binding site [nucleotide binding]; other site
93062006518	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
93062006519	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
93062006520	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
93062006521	23S rRNA interface [nucleotide binding]; other site
93062006522	putative translocon interaction site; other site
93062006523	signal recognition particle (SRP54) interaction site; other site
93062006524	L23 interface [polypeptide binding]; other site
93062006525	trigger factor interaction site; other site
93062006526	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
93062006527	23S rRNA interface [nucleotide binding]; other site
93062006528	5S rRNA interface [nucleotide binding]; other site
93062006529	putative antibiotic binding site [chemical binding]; other site
93062006530	L25 interface [polypeptide binding]; other site
93062006531	L27 interface [polypeptide binding]; other site
93062006532	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
93062006533	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
93062006534	G-X-X-G motif; other site
93062006535	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
93062006536	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
93062006537	putative translocon binding site; other site
93062006538	protein-rRNA interface [nucleotide binding]; other site
93062006539	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
93062006540	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
93062006541	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
93062006542	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
93062006543	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
93062006544	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
93062006545	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
93062006546	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
93062006547	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
93062006548	DNA topoisomerase III; Provisional; Region: PRK07726
93062006549	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
93062006550	active site
93062006551	putative interdomain interaction site [polypeptide binding]; other site
93062006552	putative metal-binding site [ion binding]; other site
93062006553	putative nucleotide binding site [chemical binding]; other site
93062006554	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
93062006555	domain I; other site
93062006556	DNA binding groove [nucleotide binding]
93062006557	phosphate binding site [ion binding]; other site
93062006558	domain II; other site
93062006559	domain III; other site
93062006560	nucleotide binding site [chemical binding]; other site
93062006561	catalytic site [active]
93062006562	domain IV; other site
93062006563	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
93062006564	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062006565	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
93062006566	Coenzyme A binding pocket [chemical binding]; other site
93062006567	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
93062006568	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
93062006569	Predicted permeases [General function prediction only]; Region: COG0679
93062006570	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
93062006571	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
93062006572	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
93062006573	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
93062006574	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
93062006575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006576	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062006577	putative substrate translocation pore; other site
93062006578	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062006579	Transcriptional regulators [Transcription]; Region: MarR; COG1846
93062006580	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
93062006581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062006582	FeS/SAM binding site; other site
93062006583	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
93062006584	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
93062006585	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
93062006586	GTP binding site; other site
93062006587	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
93062006588	MoaE interaction surface [polypeptide binding]; other site
93062006589	MoeB interaction surface [polypeptide binding]; other site
93062006590	thiocarboxylated glycine; other site
93062006591	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
93062006592	MoaE homodimer interface [polypeptide binding]; other site
93062006593	MoaD interaction [polypeptide binding]; other site
93062006594	active site residues [active]
93062006595	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
93062006596	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
93062006597	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
93062006598	dimer interface [polypeptide binding]; other site
93062006599	putative functional site; other site
93062006600	putative MPT binding site; other site
93062006601	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
93062006602	trimer interface [polypeptide binding]; other site
93062006603	dimer interface [polypeptide binding]; other site
93062006604	putative active site [active]
93062006605	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
93062006606	MPT binding site; other site
93062006607	trimer interface [polypeptide binding]; other site
93062006608	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
93062006609	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
93062006610	ATP binding site [chemical binding]; other site
93062006611	substrate interface [chemical binding]; other site
93062006612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062006613	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
93062006614	Walker A/P-loop; other site
93062006615	ATP binding site [chemical binding]; other site
93062006616	Q-loop/lid; other site
93062006617	ABC transporter signature motif; other site
93062006618	Walker B; other site
93062006619	D-loop; other site
93062006620	H-loop/switch region; other site
93062006621	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
93062006622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062006623	dimer interface [polypeptide binding]; other site
93062006624	conserved gate region; other site
93062006625	putative PBP binding loops; other site
93062006626	ABC-ATPase subunit interface; other site
93062006627	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
93062006628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
93062006629	substrate binding pocket [chemical binding]; other site
93062006630	membrane-bound complex binding site; other site
93062006631	hinge residues; other site
93062006632	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
93062006633	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062006634	Coenzyme A binding pocket [chemical binding]; other site
93062006635	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
93062006636	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
93062006637	active site
93062006638	dimerization interface [polypeptide binding]; other site
93062006639	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
93062006640	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
93062006641	intersubunit interface [polypeptide binding]; other site
93062006642	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
93062006643	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
93062006644	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
93062006645	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
93062006646	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
93062006647	alpha-gamma subunit interface [polypeptide binding]; other site
93062006648	beta-gamma subunit interface [polypeptide binding]; other site
93062006649	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
93062006650	gamma-beta subunit interface [polypeptide binding]; other site
93062006651	alpha-beta subunit interface [polypeptide binding]; other site
93062006652	urease subunit alpha; Reviewed; Region: ureC; PRK13207
93062006653	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
93062006654	subunit interactions [polypeptide binding]; other site
93062006655	active site
93062006656	flap region; other site
93062006657	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
93062006658	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
93062006659	dimer interface [polypeptide binding]; other site
93062006660	catalytic residues [active]
93062006661	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
93062006662	UreF; Region: UreF; pfam01730
93062006663	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
93062006664	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
93062006665	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062006666	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062006667	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062006668	Helix-turn-helix domain; Region: HTH_18; pfam12833
93062006669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
93062006670	Surface antigen [General function prediction only]; Region: COG3942
93062006671	CHAP domain; Region: CHAP; pfam05257
93062006672	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
93062006673	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
93062006674	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
93062006675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
93062006676	Surface antigen [General function prediction only]; Region: COG3942
93062006677	CHAP domain; Region: CHAP; pfam05257
93062006678	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
93062006679	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
93062006680	putative ligand binding site [chemical binding]; other site
93062006681	putative NAD binding site [chemical binding]; other site
93062006682	catalytic site [active]
93062006683	hypothetical protein; Provisional; Region: PRK06753
93062006684	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
93062006685	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
93062006686	Lysozyme subfamily 2; Region: LYZ2; smart00047
93062006687	Uncharacterized conserved protein [Function unknown]; Region: COG2427
93062006688	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
93062006689	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
93062006690	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
93062006691	4Fe-4S binding domain; Region: Fer4; pfam00037
93062006692	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
93062006693	[4Fe-4S] binding site [ion binding]; other site
93062006694	molybdopterin cofactor binding site; other site
93062006695	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
93062006696	molybdopterin cofactor binding site; other site
93062006697	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
93062006698	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
93062006699	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
93062006700	active site
93062006701	Predicted transcriptional regulator [Transcription]; Region: COG2378
93062006702	HTH domain; Region: HTH_11; pfam08279
93062006703	CAAX protease self-immunity; Region: Abi; pfam02517
93062006704	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
93062006705	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
93062006706	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
93062006707	putative active site [active]
93062006708	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
93062006709	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
93062006710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062006711	active site
93062006712	motif I; other site
93062006713	motif II; other site
93062006714	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
93062006715	Sodium Bile acid symporter family; Region: SBF; pfam01758
93062006716	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
93062006717	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062006718	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062006719	active site turn [active]
93062006720	phosphorylation site [posttranslational modification]
93062006721	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
93062006722	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
93062006723	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
93062006724	putative active site [active]
93062006725	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
93062006726	putative hydrophobic ligand binding site [chemical binding]; other site
93062006727	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
93062006728	oxidoreductase; Provisional; Region: PRK07985
93062006729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062006730	NAD(P) binding site [chemical binding]; other site
93062006731	active site
93062006732	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
93062006733	amidohydrolase; Region: amidohydrolases; TIGR01891
93062006734	metal binding site [ion binding]; metal-binding site
93062006735	dimer interface [polypeptide binding]; other site
93062006736	imidazolonepropionase; Validated; Region: PRK09356
93062006737	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
93062006738	active site
93062006739	urocanate hydratase; Provisional; Region: PRK05414
93062006740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062006741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062006742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
93062006743	dimerization interface [polypeptide binding]; other site
93062006744	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
93062006745	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
93062006746	putative active site [active]
93062006747	putative Mg binding site [ion binding]; other site
93062006748	formimidoylglutamase; Provisional; Region: PRK13775
93062006749	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
93062006750	putative active site [active]
93062006751	putative metal binding site [ion binding]; other site
93062006752	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
93062006753	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
93062006754	tetramer (dimer of dimers) interface [polypeptide binding]; other site
93062006755	active site
93062006756	dimer interface [polypeptide binding]; other site
93062006757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
93062006758	MOSC domain; Region: MOSC; pfam03473
93062006759	3-alpha domain; Region: 3-alpha; pfam03475
93062006760	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
93062006761	active site
93062006762	catalytic residues [active]
93062006763	Uncharacterized conserved protein [Function unknown]; Region: COG1742
93062006764	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
93062006765	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
93062006766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062006767	Walker A/P-loop; other site
93062006768	ATP binding site [chemical binding]; other site
93062006769	Q-loop/lid; other site
93062006770	ABC transporter signature motif; other site
93062006771	Walker B; other site
93062006772	D-loop; other site
93062006773	H-loop/switch region; other site
93062006774	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
93062006775	Predicted membrane protein [Function unknown]; Region: COG3152
93062006776	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
93062006777	active site
93062006778	DNA binding site [nucleotide binding]
93062006779	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
93062006780	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
93062006781	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
93062006782	homotetramer interface [polypeptide binding]; other site
93062006783	FMN binding site [chemical binding]; other site
93062006784	homodimer contacts [polypeptide binding]; other site
93062006785	putative active site [active]
93062006786	putative substrate binding site [chemical binding]; other site
93062006787	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
93062006788	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
93062006789	oligomer interface [polypeptide binding]; other site
93062006790	metal binding site [ion binding]; metal-binding site
93062006791	metal binding site [ion binding]; metal-binding site
93062006792	putative Cl binding site [ion binding]; other site
93062006793	aspartate ring; other site
93062006794	basic sphincter; other site
93062006795	hydrophobic gate; other site
93062006796	periplasmic entrance; other site
93062006797	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
93062006798	active site
93062006799	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
93062006800	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
93062006801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006802	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
93062006803	putative substrate translocation pore; other site
93062006804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006805	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
93062006806	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
93062006807	HlyD family secretion protein; Region: HlyD_3; pfam13437
93062006808	lipoyl-biotinyl attachment site [posttranslational modification]; other site
93062006809	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
93062006810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006811	putative substrate translocation pore; other site
93062006812	Predicted membrane protein [Function unknown]; Region: COG4640
93062006813	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
93062006814	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062006815	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
93062006816	putative Zn2+ binding site [ion binding]; other site
93062006817	putative DNA binding site [nucleotide binding]; other site
93062006818	Uncharacterized conserved protein [Function unknown]; Region: COG1434
93062006819	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
93062006820	putative active site [active]
93062006821	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
93062006822	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
93062006823	Walker A/P-loop; other site
93062006824	ATP binding site [chemical binding]; other site
93062006825	Q-loop/lid; other site
93062006826	ABC transporter signature motif; other site
93062006827	Walker B; other site
93062006828	D-loop; other site
93062006829	H-loop/switch region; other site
93062006830	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
93062006831	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
93062006832	FtsX-like permease family; Region: FtsX; pfam02687
93062006833	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062006834	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062006835	active site
93062006836	phosphorylation site [posttranslational modification]
93062006837	intermolecular recognition site; other site
93062006838	dimerization interface [polypeptide binding]; other site
93062006839	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062006840	DNA binding site [nucleotide binding]
93062006841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
93062006842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
93062006843	dimerization interface [polypeptide binding]; other site
93062006844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
93062006845	dimer interface [polypeptide binding]; other site
93062006846	phosphorylation site [posttranslational modification]
93062006847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062006848	ATP binding site [chemical binding]; other site
93062006849	Mg2+ binding site [ion binding]; other site
93062006850	G-X-G motif; other site
93062006851	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
93062006852	LytTr DNA-binding domain; Region: LytTR; smart00850
93062006853	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
93062006854	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
93062006855	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
93062006856	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
93062006857	L-lactate permease; Region: Lactate_perm; cl00701
93062006858	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
93062006859	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062006860	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
93062006861	Coenzyme A binding pocket [chemical binding]; other site
93062006862	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
93062006863	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
93062006864	NAD(P) binding site [chemical binding]; other site
93062006865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062006866	Coenzyme A binding pocket [chemical binding]; other site
93062006867	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
93062006868	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
93062006869	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062006870	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
93062006871	Predicted membrane protein [Function unknown]; Region: COG1511
93062006872	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
93062006873	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
93062006874	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
93062006875	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
93062006876	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
93062006877	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
93062006878	Cl binding site [ion binding]; other site
93062006879	oligomer interface [polypeptide binding]; other site
93062006880	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
93062006881	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062006882	active site turn [active]
93062006883	phosphorylation site [posttranslational modification]
93062006884	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062006885	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
93062006886	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
93062006887	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
93062006888	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
93062006889	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
93062006890	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
93062006891	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
93062006892	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
93062006893	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062006894	MarR family; Region: MarR_2; pfam12802
93062006895	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
93062006896	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
93062006897	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
93062006898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006899	putative substrate translocation pore; other site
93062006900	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
93062006901	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
93062006902	DNA binding residues [nucleotide binding]
93062006903	dimer interface [polypeptide binding]; other site
93062006904	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
93062006905	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
93062006906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062006907	active site
93062006908	phosphorylation site [posttranslational modification]
93062006909	intermolecular recognition site; other site
93062006910	dimerization interface [polypeptide binding]; other site
93062006911	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
93062006912	DNA binding residues [nucleotide binding]
93062006913	dimerization interface [polypeptide binding]; other site
93062006914	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
93062006915	Histidine kinase; Region: HisKA_3; pfam07730
93062006916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062006917	ATP binding site [chemical binding]; other site
93062006918	Mg2+ binding site [ion binding]; other site
93062006919	G-X-G motif; other site
93062006920	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
93062006921	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
93062006922	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
93062006923	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
93062006924	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
93062006925	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
93062006926	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
93062006927	[4Fe-4S] binding site [ion binding]; other site
93062006928	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
93062006929	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
93062006930	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
93062006931	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
93062006932	molybdopterin cofactor binding site; other site
93062006933	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
93062006934	active site
93062006935	SAM binding site [chemical binding]; other site
93062006936	homodimer interface [polypeptide binding]; other site
93062006937	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
93062006938	[2Fe-2S] cluster binding site [ion binding]; other site
93062006939	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
93062006940	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
93062006941	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
93062006942	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
93062006943	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
93062006944	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
93062006945	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
93062006946	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
93062006947	putative active site [active]
93062006948	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
93062006949	active site
93062006950	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
93062006951	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062006952	Coenzyme A binding pocket [chemical binding]; other site
93062006953	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
93062006954	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
93062006955	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
93062006956	putative hydrophobic ligand binding site [chemical binding]; other site
93062006957	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
93062006958	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
93062006959	intersubunit interface [polypeptide binding]; other site
93062006960	YodA lipocalin-like domain; Region: YodA; pfam09223
93062006961	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
93062006962	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
93062006963	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
93062006964	Thioredoxin; Region: Thioredoxin_4; cl17273
93062006965	FemAB family; Region: FemAB; pfam02388
93062006966	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
93062006967	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
93062006968	Walker A/P-loop; other site
93062006969	ATP binding site [chemical binding]; other site
93062006970	Q-loop/lid; other site
93062006971	ABC transporter signature motif; other site
93062006972	Walker B; other site
93062006973	D-loop; other site
93062006974	H-loop/switch region; other site
93062006975	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
93062006976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062006977	dimer interface [polypeptide binding]; other site
93062006978	conserved gate region; other site
93062006979	putative PBP binding loops; other site
93062006980	ABC-ATPase subunit interface; other site
93062006981	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
93062006982	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
93062006983	substrate binding pocket [chemical binding]; other site
93062006984	membrane-bound complex binding site; other site
93062006985	hinge residues; other site
93062006986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006987	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062006988	putative substrate translocation pore; other site
93062006989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062006990	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
93062006991	catalytic core [active]
93062006992	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
93062006993	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
93062006994	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
93062006995	B domain; Region: B; pfam02216
93062006996	B domain; Region: B; pfam02216
93062006997	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
93062006998	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
93062006999	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
93062007000	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
93062007001	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
93062007002	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
93062007003	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
93062007004	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
93062007005	catalytic residue [active]
93062007006	biotin synthase; Validated; Region: PRK06256
93062007007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062007008	FeS/SAM binding site; other site
93062007009	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
93062007010	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
93062007011	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
93062007012	inhibitor-cofactor binding pocket; inhibition site
93062007013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062007014	catalytic residue [active]
93062007015	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
93062007016	AAA domain; Region: AAA_26; pfam13500
93062007017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062007018	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
93062007019	Walker A/P-loop; other site
93062007020	ATP binding site [chemical binding]; other site
93062007021	Q-loop/lid; other site
93062007022	ABC transporter signature motif; other site
93062007023	Walker B; other site
93062007024	D-loop; other site
93062007025	H-loop/switch region; other site
93062007026	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
93062007027	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
93062007028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062007029	Walker A/P-loop; other site
93062007030	ATP binding site [chemical binding]; other site
93062007031	Q-loop/lid; other site
93062007032	ABC transporter signature motif; other site
93062007033	Walker B; other site
93062007034	D-loop; other site
93062007035	H-loop/switch region; other site
93062007036	Predicted membrane protein [Function unknown]; Region: COG2246
93062007037	GtrA-like protein; Region: GtrA; pfam04138
93062007038	glycerate kinase; Region: TIGR00045
93062007039	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
93062007040	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
93062007041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007042	putative substrate translocation pore; other site
93062007043	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
93062007044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
93062007045	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
93062007046	putative phosphoesterase; Region: acc_ester; TIGR03729
93062007047	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
93062007048	Spore germination protein; Region: Spore_permease; cl17796
93062007049	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
93062007050	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
93062007051	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
93062007052	Beta-lactamase; Region: Beta-lactamase; pfam00144
93062007053	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
93062007054	extended (e) SDRs; Region: SDR_e; cd08946
93062007055	NAD(P) binding site [chemical binding]; other site
93062007056	active site
93062007057	substrate binding site [chemical binding]; other site
93062007058	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
93062007059	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
93062007060	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
93062007061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007062	putative substrate translocation pore; other site
93062007063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062007065	dimer interface [polypeptide binding]; other site
93062007066	conserved gate region; other site
93062007067	ABC-ATPase subunit interface; other site
93062007068	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
93062007069	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
93062007070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062007071	dimer interface [polypeptide binding]; other site
93062007072	conserved gate region; other site
93062007073	putative PBP binding loops; other site
93062007074	ABC-ATPase subunit interface; other site
93062007075	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
93062007076	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
93062007077	Walker A/P-loop; other site
93062007078	ATP binding site [chemical binding]; other site
93062007079	Q-loop/lid; other site
93062007080	ABC transporter signature motif; other site
93062007081	Walker B; other site
93062007082	D-loop; other site
93062007083	H-loop/switch region; other site
93062007084	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
93062007085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
93062007086	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
93062007087	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
93062007088	amino acid transporter; Region: 2A0306; TIGR00909
93062007089	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
93062007090	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
93062007091	substrate binding pocket [chemical binding]; other site
93062007092	catalytic triad [active]
93062007093	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
93062007094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007095	putative substrate translocation pore; other site
93062007096	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
93062007097	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
93062007098	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062007099	Walker A/P-loop; other site
93062007100	ATP binding site [chemical binding]; other site
93062007101	Q-loop/lid; other site
93062007102	ABC transporter signature motif; other site
93062007103	Walker B; other site
93062007104	D-loop; other site
93062007105	H-loop/switch region; other site
93062007106	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
93062007107	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
93062007108	oligomer interface [polypeptide binding]; other site
93062007109	active site
93062007110	metal binding site [ion binding]; metal-binding site
93062007111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
93062007112	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
93062007113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
93062007114	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
93062007115	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
93062007116	active site
93062007117	FMN binding site [chemical binding]; other site
93062007118	substrate binding site [chemical binding]; other site
93062007119	3Fe-4S cluster binding site [ion binding]; other site
93062007120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007121	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062007122	putative substrate translocation pore; other site
93062007123	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
93062007124	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062007125	Walker A/P-loop; other site
93062007126	ATP binding site [chemical binding]; other site
93062007127	Q-loop/lid; other site
93062007128	ABC transporter signature motif; other site
93062007129	Walker B; other site
93062007130	D-loop; other site
93062007131	H-loop/switch region; other site
93062007132	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
93062007133	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
93062007134	Walker A/P-loop; other site
93062007135	ATP binding site [chemical binding]; other site
93062007136	Q-loop/lid; other site
93062007137	ABC transporter signature motif; other site
93062007138	Walker B; other site
93062007139	D-loop; other site
93062007140	H-loop/switch region; other site
93062007141	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
93062007142	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
93062007143	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
93062007144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062007145	dimer interface [polypeptide binding]; other site
93062007146	conserved gate region; other site
93062007147	putative PBP binding loops; other site
93062007148	ABC-ATPase subunit interface; other site
93062007149	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
93062007150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
93062007151	dimer interface [polypeptide binding]; other site
93062007152	conserved gate region; other site
93062007153	putative PBP binding loops; other site
93062007154	ABC-ATPase subunit interface; other site
93062007155	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
93062007156	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
93062007157	substrate binding site [chemical binding]; other site
93062007158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
93062007159	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
93062007160	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
93062007161	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
93062007162	AbgT putative transporter family; Region: ABG_transport; pfam03806
93062007163	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
93062007164	Uncharacterized conserved protein [Function unknown]; Region: COG2128
93062007165	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
93062007166	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
93062007167	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
93062007168	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
93062007169	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
93062007170	classical (c) SDRs; Region: SDR_c; cd05233
93062007171	NAD(P) binding site [chemical binding]; other site
93062007172	active site
93062007173	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062007174	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062007175	Protein of unknown function, DUF576; Region: DUF576; pfam04507
93062007176	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
93062007177	PLD-like domain; Region: PLDc_2; pfam13091
93062007178	putative homodimer interface [polypeptide binding]; other site
93062007179	putative active site [active]
93062007180	catalytic site [active]
93062007181	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
93062007182	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
93062007183	ATP binding site [chemical binding]; other site
93062007184	putative Mg++ binding site [ion binding]; other site
93062007185	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
93062007186	nucleotide binding region [chemical binding]; other site
93062007187	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
93062007188	ATP-binding site [chemical binding]; other site
93062007189	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
93062007190	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
93062007191	active site
93062007192	8-oxo-dGMP binding site [chemical binding]; other site
93062007193	nudix motif; other site
93062007194	metal binding site [ion binding]; metal-binding site
93062007195	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
93062007196	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
93062007197	active site
93062007198	substrate binding site [chemical binding]; other site
93062007199	metal binding site [ion binding]; metal-binding site
93062007200	H+ Antiporter protein; Region: 2A0121; TIGR00900
93062007201	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062007202	legume lectins; Region: lectin_L-type; cl14058
93062007203	homotetramer interaction site [polypeptide binding]; other site
93062007204	carbohydrate binding site [chemical binding]; other site
93062007205	metal binding site [ion binding]; metal-binding site
93062007206	G5 domain; Region: G5; pfam07501
93062007207	G5 domain; Region: G5; pfam07501
93062007208	G5 domain; Region: G5; pfam07501
93062007209	G5 domain; Region: G5; pfam07501
93062007210	G5 domain; Region: G5; pfam07501
93062007211	G5 domain; Region: G5; pfam07501
93062007212	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
93062007213	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062007214	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062007215	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062007216	Transcriptional regulators [Transcription]; Region: MarR; COG1846
93062007217	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
93062007218	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
93062007219	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
93062007220	active site
93062007221	tetramer interface; other site
93062007222	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062007223	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062007224	Fibronectin binding repeat; Region: Fn_bind; pfam02986
93062007225	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
93062007226	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062007227	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062007228	Fibronectin binding repeat; Region: Fn_bind; pfam02986
93062007229	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
93062007230	GntP family permease; Region: GntP_permease; pfam02447
93062007231	fructuronate transporter; Provisional; Region: PRK10034; cl15264
93062007232	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
93062007233	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
93062007234	N- and C-terminal domain interface [polypeptide binding]; other site
93062007235	active site
93062007236	catalytic site [active]
93062007237	metal binding site [ion binding]; metal-binding site
93062007238	carbohydrate binding site [chemical binding]; other site
93062007239	ATP binding site [chemical binding]; other site
93062007240	Transcriptional regulators [Transcription]; Region: GntR; COG1802
93062007241	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
93062007242	DNA-binding site [nucleotide binding]; DNA binding site
93062007243	FCD domain; Region: FCD; pfam07729
93062007244	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
93062007245	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
93062007246	DNA binding residues [nucleotide binding]
93062007247	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
93062007248	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
93062007249	synthetase active site [active]
93062007250	NTP binding site [chemical binding]; other site
93062007251	metal binding site [ion binding]; metal-binding site
93062007252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
93062007253	Predicted membrane protein [Function unknown]; Region: COG1289
93062007254	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
93062007255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007256	D-galactonate transporter; Region: 2A0114; TIGR00893
93062007257	putative substrate translocation pore; other site
93062007258	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
93062007259	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
93062007260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007261	Major Facilitator Superfamily; Region: MFS_1; pfam07690
93062007262	putative substrate translocation pore; other site
93062007263	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062007264	MarR family; Region: MarR; pfam01047
93062007265	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
93062007266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062007267	Walker A/P-loop; other site
93062007268	ATP binding site [chemical binding]; other site
93062007269	Q-loop/lid; other site
93062007270	ABC transporter signature motif; other site
93062007271	Walker B; other site
93062007272	D-loop; other site
93062007273	H-loop/switch region; other site
93062007274	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
93062007275	Uncharacterized membrane protein [Function unknown]; Region: COG3949
93062007276	Predicted esterase [General function prediction only]; Region: COG0400
93062007277	putative hydrolase; Provisional; Region: PRK11460
93062007278	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
93062007279	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
93062007280	Zn binding site [ion binding]; other site
93062007281	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
93062007282	Zn binding site [ion binding]; other site
93062007283	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062007284	MarR family; Region: MarR; pfam01047
93062007285	Predicted acetyltransferase [General function prediction only]; Region: COG2388
93062007286	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
93062007287	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
93062007288	putative metal binding site [ion binding]; other site
93062007289	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
93062007290	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
93062007291	dimer interface [polypeptide binding]; other site
93062007292	FMN binding site [chemical binding]; other site
93062007293	D-lactate dehydrogenase; Provisional; Region: PRK12480
93062007294	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
93062007295	homodimer interface [polypeptide binding]; other site
93062007296	ligand binding site [chemical binding]; other site
93062007297	NAD binding site [chemical binding]; other site
93062007298	catalytic site [active]
93062007299	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
93062007300	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
93062007301	active site
93062007302	motif I; other site
93062007303	motif II; other site
93062007304	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
93062007305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
93062007306	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
93062007307	Walker A/P-loop; other site
93062007308	ATP binding site [chemical binding]; other site
93062007309	Q-loop/lid; other site
93062007310	ABC transporter signature motif; other site
93062007311	Walker B; other site
93062007312	D-loop; other site
93062007313	H-loop/switch region; other site
93062007314	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
93062007315	active site
93062007316	catalytic site [active]
93062007317	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
93062007318	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062007319	Coenzyme A binding pocket [chemical binding]; other site
93062007320	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
93062007321	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
93062007322	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
93062007323	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
93062007324	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
93062007325	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
93062007326	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
93062007327	EamA-like transporter family; Region: EamA; pfam00892
93062007328	EamA-like transporter family; Region: EamA; pfam00892
93062007329	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
93062007330	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
93062007331	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
93062007332	catalytic residues [active]
93062007333	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
93062007334	active site
93062007335	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
93062007336	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
93062007337	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
93062007338	active site turn [active]
93062007339	phosphorylation site [posttranslational modification]
93062007340	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
93062007341	HPr interaction site; other site
93062007342	glycerol kinase (GK) interaction site [polypeptide binding]; other site
93062007343	active site
93062007344	phosphorylation site [posttranslational modification]
93062007345	pyruvate oxidase; Provisional; Region: PRK08611
93062007346	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
93062007347	PYR/PP interface [polypeptide binding]; other site
93062007348	tetramer interface [polypeptide binding]; other site
93062007349	dimer interface [polypeptide binding]; other site
93062007350	TPP binding site [chemical binding]; other site
93062007351	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
93062007352	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
93062007353	TPP-binding site [chemical binding]; other site
93062007354	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
93062007355	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
93062007356	Transcriptional regulator [Transcription]; Region: LysR; COG0583
93062007357	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
93062007358	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
93062007359	putative dimerization interface [polypeptide binding]; other site
93062007360	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
93062007361	Surface antigen [General function prediction only]; Region: COG3942
93062007362	CHAP domain; Region: CHAP; pfam05257
93062007363	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
93062007364	homodimer interface [polypeptide binding]; other site
93062007365	catalytic residues [active]
93062007366	NAD binding site [chemical binding]; other site
93062007367	substrate binding pocket [chemical binding]; other site
93062007368	flexible flap; other site
93062007369	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
93062007370	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
93062007371	dimer interface [polypeptide binding]; other site
93062007372	active site
93062007373	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
93062007374	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
93062007375	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
93062007376	DNA binding site [nucleotide binding]
93062007377	active site
93062007378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062007379	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
93062007380	Walker A motif; other site
93062007381	ATP binding site [chemical binding]; other site
93062007382	Walker B motif; other site
93062007383	arginine finger; other site
93062007384	UvrB/uvrC motif; Region: UVR; pfam02151
93062007385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
93062007386	Walker A motif; other site
93062007387	ATP binding site [chemical binding]; other site
93062007388	Walker B motif; other site
93062007389	arginine finger; other site
93062007390	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
93062007391	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
93062007392	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
93062007393	G1 box; other site
93062007394	GTP/Mg2+ binding site [chemical binding]; other site
93062007395	Switch I region; other site
93062007396	G2 box; other site
93062007397	G3 box; other site
93062007398	Switch II region; other site
93062007399	G4 box; other site
93062007400	G5 box; other site
93062007401	Nucleoside recognition; Region: Gate; pfam07670
93062007402	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
93062007403	Nucleoside recognition; Region: Gate; pfam07670
93062007404	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
93062007405	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
93062007406	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
93062007407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
93062007408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
93062007409	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
93062007410	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
93062007411	Glutamate binding site [chemical binding]; other site
93062007412	homodimer interface [polypeptide binding]; other site
93062007413	NAD binding site [chemical binding]; other site
93062007414	catalytic residues [active]
93062007415	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
93062007416	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
93062007417	active site
93062007418	substrate binding site [chemical binding]; other site
93062007419	trimer interface [polypeptide binding]; other site
93062007420	CoA binding site [chemical binding]; other site
93062007421	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
93062007422	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
93062007423	metal-binding site [ion binding]
93062007424	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
93062007425	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
93062007426	metal-binding site [ion binding]
93062007427	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
93062007428	Soluble P-type ATPase [General function prediction only]; Region: COG4087
93062007429	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
93062007430	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
93062007431	metal-binding site [ion binding]
93062007432	D-lactate dehydrogenase; Validated; Region: PRK08605
93062007433	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
93062007434	homodimer interface [polypeptide binding]; other site
93062007435	ligand binding site [chemical binding]; other site
93062007436	NAD binding site [chemical binding]; other site
93062007437	catalytic site [active]
93062007438	transaminase; Reviewed; Region: PRK08068
93062007439	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062007440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062007441	homodimer interface [polypeptide binding]; other site
93062007442	catalytic residue [active]
93062007443	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
93062007444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
93062007445	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
93062007446	active site lid residues [active]
93062007447	substrate binding pocket [chemical binding]; other site
93062007448	catalytic residues [active]
93062007449	substrate-Mg2+ binding site; other site
93062007450	aspartate-rich region 1; other site
93062007451	aspartate-rich region 2; other site
93062007452	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
93062007453	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
93062007454	active site
93062007455	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
93062007456	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
93062007457	Surface antigen [General function prediction only]; Region: COG3942
93062007458	CHAP domain; Region: CHAP; pfam05257
93062007459	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
93062007460	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
93062007461	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
93062007462	catalytic triad [active]
93062007463	catalytic triad [active]
93062007464	oxyanion hole [active]
93062007465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062007466	Coenzyme A binding pocket [chemical binding]; other site
93062007467	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
93062007468	N-acetyl-D-glucosamine binding site [chemical binding]; other site
93062007469	catalytic residue [active]
93062007470	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
93062007471	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
93062007472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
93062007473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
93062007474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
93062007475	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
93062007476	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
93062007477	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
93062007478	NmrA-like family; Region: NmrA; pfam05368
93062007479	NADP binding site [chemical binding]; other site
93062007480	active site
93062007481	regulatory binding site [polypeptide binding]; other site
93062007482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
93062007483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
93062007484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
93062007485	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
93062007486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
93062007487	NAD(P) binding site [chemical binding]; other site
93062007488	active site
93062007489	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
93062007490	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
93062007491	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
93062007492	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
93062007493	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
93062007494	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
93062007495	Nucleoside recognition; Region: Gate; pfam07670
93062007496	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
93062007497	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
93062007498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
93062007499	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
93062007500	Phosphotransferase enzyme family; Region: APH; pfam01636
93062007501	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
93062007502	active site
93062007503	ATP binding site [chemical binding]; other site
93062007504	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
93062007505	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
93062007506	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
93062007507	quinone interaction residues [chemical binding]; other site
93062007508	active site
93062007509	catalytic residues [active]
93062007510	FMN binding site [chemical binding]; other site
93062007511	substrate binding site [chemical binding]; other site
93062007512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
93062007513	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
93062007514	dimer interface [polypeptide binding]; other site
93062007515	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
93062007516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
93062007517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
93062007518	Predicted acyl esterases [General function prediction only]; Region: COG2936
93062007519	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
93062007520	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
93062007521	tetramerization interface [polypeptide binding]; other site
93062007522	active site
93062007523	pantoate--beta-alanine ligase; Region: panC; TIGR00018
93062007524	Pantoate-beta-alanine ligase; Region: PanC; cd00560
93062007525	active site
93062007526	ATP-binding site [chemical binding]; other site
93062007527	pantoate-binding site; other site
93062007528	HXXH motif; other site
93062007529	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
93062007530	oligomerization interface [polypeptide binding]; other site
93062007531	active site
93062007532	metal binding site [ion binding]; metal-binding site
93062007533	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
93062007534	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
93062007535	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
93062007536	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
93062007537	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
93062007538	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
93062007539	tetramer (dimer of dimers) interface [polypeptide binding]; other site
93062007540	NAD binding site [chemical binding]; other site
93062007541	dimer interface [polypeptide binding]; other site
93062007542	substrate binding site [chemical binding]; other site
93062007543	amino acid transporter; Region: 2A0306; TIGR00909
93062007544	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
93062007545	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
93062007546	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
93062007547	inhibitor-cofactor binding pocket; inhibition site
93062007548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062007549	catalytic residue [active]
93062007550	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
93062007551	catalytic residue [active]
93062007552	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
93062007553	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
93062007554	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
93062007555	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
93062007556	acyl-activating enzyme (AAE) consensus motif; other site
93062007557	AMP binding site [chemical binding]; other site
93062007558	active site
93062007559	CoA binding site [chemical binding]; other site
93062007560	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
93062007561	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
93062007562	choline dehydrogenase; Validated; Region: PRK02106
93062007563	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
93062007564	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
93062007565	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
93062007566	tetramerization interface [polypeptide binding]; other site
93062007567	NAD(P) binding site [chemical binding]; other site
93062007568	catalytic residues [active]
93062007569	Predicted transcriptional regulators [Transcription]; Region: COG1510
93062007570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
93062007571	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
93062007572	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
93062007573	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
93062007574	FeS/SAM binding site; other site
93062007575	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
93062007576	Class III ribonucleotide reductase; Region: RNR_III; cd01675
93062007577	effector binding site; other site
93062007578	active site
93062007579	Zn binding site [ion binding]; other site
93062007580	glycine loop; other site
93062007581	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
93062007582	Citrate transporter; Region: CitMHS; pfam03600
93062007583	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
93062007584	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
93062007585	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
93062007586	Flavodoxin; Region: Flavodoxin_1; pfam00258
93062007587	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
93062007588	FAD binding pocket [chemical binding]; other site
93062007589	FAD binding motif [chemical binding]; other site
93062007590	catalytic residues [active]
93062007591	NAD binding pocket [chemical binding]; other site
93062007592	phosphate binding motif [ion binding]; other site
93062007593	beta-alpha-beta structure motif; other site
93062007594	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
93062007595	catalytic residues [active]
93062007596	dimer interface [polypeptide binding]; other site
93062007597	FtsX-like permease family; Region: FtsX; pfam02687
93062007598	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
93062007599	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
93062007600	Walker A/P-loop; other site
93062007601	ATP binding site [chemical binding]; other site
93062007602	Q-loop/lid; other site
93062007603	ABC transporter signature motif; other site
93062007604	Walker B; other site
93062007605	D-loop; other site
93062007606	H-loop/switch region; other site
93062007607	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
93062007608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
93062007609	ATP binding site [chemical binding]; other site
93062007610	Mg2+ binding site [ion binding]; other site
93062007611	G-X-G motif; other site
93062007612	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
93062007613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
93062007614	active site
93062007615	phosphorylation site [posttranslational modification]
93062007616	intermolecular recognition site; other site
93062007617	dimerization interface [polypeptide binding]; other site
93062007618	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
93062007619	DNA binding site [nucleotide binding]
93062007620	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
93062007621	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
93062007622	dimer interface [polypeptide binding]; other site
93062007623	active site
93062007624	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
93062007625	Protein of unknown function (DUF2648); Region: DUF2648; pfam10855
93062007626	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
93062007627	MarR family; Region: MarR_2; pfam12802
93062007628	Predicted esterase [General function prediction only]; Region: COG0627
93062007629	S-formylglutathione hydrolase; Region: PLN02442
93062007630	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
93062007631	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
93062007632	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
93062007633	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
93062007634	ligand binding site [chemical binding]; other site
93062007635	flexible hinge region; other site
93062007636	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
93062007637	carbamate kinase; Reviewed; Region: PRK12686
93062007638	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
93062007639	putative substrate binding site [chemical binding]; other site
93062007640	nucleotide binding site [chemical binding]; other site
93062007641	nucleotide binding site [chemical binding]; other site
93062007642	homodimer interface [polypeptide binding]; other site
93062007643	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
93062007644	ornithine carbamoyltransferase; Validated; Region: PRK02102
93062007645	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
93062007646	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
93062007647	arginine deiminase; Provisional; Region: PRK01388
93062007648	Arginine repressor [Transcription]; Region: ArgR; COG1438
93062007649	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
93062007650	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
93062007651	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
93062007652	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
93062007653	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
93062007654	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
93062007655	active site
93062007656	Zn binding site [ion binding]; other site
93062007657	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
93062007658	HTH domain; Region: HTH_11; pfam08279
93062007659	PRD domain; Region: PRD; pfam00874
93062007660	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
93062007661	active site
93062007662	P-loop; other site
93062007663	phosphorylation site [posttranslational modification]
93062007664	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062007665	active site
93062007666	phosphorylation site [posttranslational modification]
93062007667	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
93062007668	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
93062007669	active site
93062007670	P-loop; other site
93062007671	phosphorylation site [posttranslational modification]
93062007672	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
93062007673	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
93062007674	active site
93062007675	phosphorylation site [posttranslational modification]
93062007676	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
93062007677	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
93062007678	Predicted membrane protein [Function unknown]; Region: COG1511
93062007679	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
93062007680	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
93062007681	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
93062007682	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
93062007683	CHAP domain; Region: CHAP; pfam05257
93062007684	Isochorismatase family; Region: Isochorismatase; pfam00857
93062007685	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
93062007686	catalytic triad [active]
93062007687	conserved cis-peptide bond; other site
93062007688	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
93062007689	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
93062007690	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
93062007691	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
93062007692	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
93062007693	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
93062007694	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
93062007695	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
93062007696	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
93062007697	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
93062007698	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
93062007699	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
93062007700	SecY translocase; Region: SecY; pfam00344
93062007701	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
93062007702	legume lectins; Region: lectin_L-type; cd01951
93062007703	homotetramer interaction site [polypeptide binding]; other site
93062007704	carbohydrate binding site [chemical binding]; other site
93062007705	metal binding site [ion binding]; metal-binding site
93062007706	Putative Ig domain; Region: He_PIG; pfam05345
93062007707	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
93062007708	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
93062007709	methionine sulfoxide reductase A; Provisional; Region: PRK05528
93062007710	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
93062007711	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
93062007712	Coenzyme A binding pocket [chemical binding]; other site
93062007713	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
93062007714	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
93062007715	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
93062007716	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
93062007717	Chain length determinant protein; Region: Wzz; cl15801
93062007718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
93062007719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
93062007720	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
93062007721	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
93062007722	DXD motif; other site
93062007723	intracellular adhesion protein D; Region: PIA_icaD; TIGR03932
93062007724	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
93062007725	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
93062007726	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
93062007727	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
93062007728	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
93062007729	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
93062007730	metal binding site [ion binding]; metal-binding site
93062007731	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
93062007732	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
93062007733	substrate binding site [chemical binding]; other site
93062007734	glutamase interaction surface [polypeptide binding]; other site
93062007735	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
93062007736	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
93062007737	catalytic residues [active]
93062007738	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
93062007739	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
93062007740	putative active site [active]
93062007741	oxyanion strand; other site
93062007742	catalytic triad [active]
93062007743	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
93062007744	putative active site pocket [active]
93062007745	4-fold oligomerization interface [polypeptide binding]; other site
93062007746	metal binding residues [ion binding]; metal-binding site
93062007747	3-fold/trimer interface [polypeptide binding]; other site
93062007748	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
93062007749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
93062007750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
93062007751	homodimer interface [polypeptide binding]; other site
93062007752	catalytic residue [active]
93062007753	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
93062007754	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
93062007755	NAD binding site [chemical binding]; other site
93062007756	dimerization interface [polypeptide binding]; other site
93062007757	product binding site; other site
93062007758	substrate binding site [chemical binding]; other site
93062007759	zinc binding site [ion binding]; other site
93062007760	catalytic residues [active]
93062007761	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
93062007762	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
93062007763	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
93062007764	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
93062007765	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
93062007766	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
93062007767	putative active site [active]
93062007768	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
93062007769	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
93062007770	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
93062007771	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062007772	Walker A/P-loop; other site
93062007773	ATP binding site [chemical binding]; other site
93062007774	Q-loop/lid; other site
93062007775	ABC transporter signature motif; other site
93062007776	Walker B; other site
93062007777	D-loop; other site
93062007778	H-loop/switch region; other site
93062007779	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
93062007780	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
93062007781	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
93062007782	Walker A/P-loop; other site
93062007783	ATP binding site [chemical binding]; other site
93062007784	Q-loop/lid; other site
93062007785	ABC transporter signature motif; other site
93062007786	Walker B; other site
93062007787	D-loop; other site
93062007788	H-loop/switch region; other site
93062007789	hypothetical protein; Provisional; Region: PRK13661
93062007790	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
93062007791	Uncharacterized conserved protein [Function unknown]; Region: COG1912
93062007792	Uncharacterized conserved protein [Function unknown]; Region: COG2353
93062007793	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
93062007794	Strictosidine synthase; Region: Str_synth; pfam03088
93062007795	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
93062007796	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
93062007797	active site residue [active]
93062007798	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
93062007799	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
93062007800	putative substrate binding pocket [chemical binding]; other site
93062007801	AC domain interface; other site
93062007802	catalytic triad [active]
93062007803	AB domain interface; other site
93062007804	interchain disulfide; other site
93062007805	hypothetical protein; Validated; Region: PRK07668
93062007806	Predicted transcriptional regulators [Transcription]; Region: COG1695
93062007807	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
93062007808	DinB superfamily; Region: DinB_2; pfam12867
93062007809	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
93062007810	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
93062007811	transmembrane helices; other site
93062007812	Predicted permeases [General function prediction only]; Region: RarD; COG2962
93062007813	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
93062007814	hypothetical protein; Provisional; Region: PRK07758
93062007815	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
93062007816	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
93062007817	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
93062007818	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
93062007819	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
93062007820	Walker A/P-loop; other site
93062007821	ATP binding site [chemical binding]; other site
93062007822	Q-loop/lid; other site
93062007823	ABC transporter signature motif; other site
93062007824	Walker B; other site
93062007825	D-loop; other site
93062007826	H-loop/switch region; other site
93062007827	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
93062007828	FtsX-like permease family; Region: FtsX; pfam02687
93062007829	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
93062007830	Integrase core domain; Region: rve; pfam00665
93062007831	Integrase core domain; Region: rve_3; cl15866
93062007832	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
93062007833	Integrase core domain; Region: rve_3; cl15866
93062007834	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
93062007835	DNA-binding site [nucleotide binding]; DNA binding site
93062007836	RNA-binding motif; other site
93062007837	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
93062007838	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
93062007839	non-specific DNA binding site [nucleotide binding]; other site
93062007840	salt bridge; other site
93062007841	sequence-specific DNA binding site [nucleotide binding]; other site
93062007842	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
93062007843	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
93062007844	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
93062007845	ParB-like nuclease domain; Region: ParBc; pfam02195
93062007846	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
93062007847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
93062007848	S-adenosylmethionine binding site [chemical binding]; other site
93062007849	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
93062007850	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
93062007851	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
93062007852	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
93062007853	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
93062007854	trmE is a tRNA modification GTPase; Region: trmE; cd04164
93062007855	G1 box; other site
93062007856	GTP/Mg2+ binding site [chemical binding]; other site
93062007857	Switch I region; other site
93062007858	G2 box; other site
93062007859	Switch II region; other site
93062007860	G3 box; other site
93062007861	G4 box; other site
93062007862	G5 box; other site
93062007863	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
93062007864	ribonuclease P; Reviewed; Region: rnpA; PRK00499
93062007865	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
93062007866	Replication initiation factor; Region: Rep_trans; pfam02486
93062007867	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
93062007868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
93062007869	putative substrate translocation pore; other site
93062007870	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076